418 results about "Propionibacterium acnes" patented technology

The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic Clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of Bacteroides, Eubacteria, Fusobacteria, Propionibacteria, Lactobacilli, anaerobic cocci, Ruminococcus, E.Coli, Gemmiger, Desullomonas, Peptostreptococcus, and fungi. The present invention also provides pharmaceutical compositions suitable for the treatment of the same chronic diseases comprising viable non-pathogenic or attenuated pathogenic Escherichia coli, at least one strain of viable non-pathogenic or attenuated pathoenic Bacteroides and at least one strain of viable non-pathogenic or attenuated pathogenic microorganism.

The present invention provides a remedy for sarcoidosis, one of systemic granulomatous diseases, and a method for treating sarcoidosis. A remedy for sarcoidosis containing a Propionibacterium acnes-targeting antibiotic such as minocycline hydrochloride and clindamycin as an active component is prepared. Further, sarcoidosis is treated by administering this remedy for sarcoidosis to sarcoidosis patients.

The present application relates to a probiotic composition comprising a probiotic bacteria. The composition is particularly useful as a food supplement for normalizing the gastro-intestinal flora. The probiotic bacteria present in the composition contain species of Propionibacterium, Lactobacillus, Bifidobacterium and Streptococcus. Also disclosed herein are methods of producing such composition and uses of the composition.

Antibacterial compositions effective against both gram positive and gram negative vegetative bacteria plus harmful gram positive sporeforming bacteria include propionibacterial metabolites in combination with two or more of the following: a lantibiotic; a lytic enzyme; and an organic acid or its salt. Methods of use are provided, as well as food products treated with these antibacterial compositions.

Methods are provided for improved immunization against coccidiosis and other bacterial, viral, or parasitic diseases in poultry. One method includes administering a solution of Propionibacterium acnes suspended in normal saline to a chick at age day one, following hatching. An anticoccidial vaccine and/or other vaccine is then administered to the chick such as by oral administration. Alternatively the method includes the steps of aseptically injecting Propionibacterium acnes in ovo at about day 18 in development, followed by post-hatching vaccination with an anticoccidial vaccine and/or other vaccine. Alternatively, either method can be utilized without the subsequent vaccination step for stimulating non-specific cell-mediated immune responses in poultry.

The subject matter of the present invention is a bacteria or mix of bacteria having an antagonistic activity with respect to stains of S. aureus, P. aeruginosa, Streptococcus pyogenes, Enterococcus faecium, Enterobacter cloacae, Proteus mirabilis, Bacteroides fragilis Staphylococcus epidermidis, Propionibacterium acnes, Candida albicans and/or Malassezia furfur as well as the use thereof in the treatment and/or prevention of infections or colonisations related to those pathogens. The invention pertains to care products containing one or more non-pathogenic antagonistic strains intended to prevent and/or treat infections or colonisations on skin, wounds, mucous membranes and appendages.

The invention belongs to the technical field of cosmetics, and particularly relates to acne treatment essence cream and a preparing method thereof. The essence cream contains aluminum starch octenylsuccinate, salicylic acid, PCA zinc, zinc gluconate, nicotinamide, tangerine orange pericarp extract, amur corktree bark extract and retinyl palmitate. The acne treatment constituents in the essence cream are obtained through screening. The new acne treatment constituents in the essence cream can effectively restrain propionibacterium acnes. Experimental studies prove that a good acne treatment effect can be realized by adding the acne treatment constituents to the essence cream. Stability studies show that the essence cream has higher stability.

The invention relates to application of a photosensitizer for treating acne. The photosensitizer is amino acid zinc phthalocyanine or a derivative thereof or organic or inorganic salt thereof which is used as the photosensitizer in photodynamic therapy for treating acne. The photosensitizer is of targeting and targeting aggressivity to target germs. Photons with special energy excite target molecules of the photosensitizer, the target molecules of the photosensitizer can transfer energy to oxygen molecules, and high energy oxygen molecules kill adjacent target germs: propionibacterium acnes, escherichia coli and staphylococcus aureus to treat acne. The photosensitizer provided by the invention used to treat acne is good in effect, free from antibiotics and hormone and tolerance, less in side effect, safe and nontoxic and economic and practical; can efficiently and quickly kill propionibacterium acnes, escherichia coli and staphylococcus aureus which induce acne to treat acne and restore skins without damaging normal cells; and is small in use level of effect medicines, and strong in effect of killing acne pathogenic bacteria.

An improved method, formulation and kit for the treatment of acne vulgaris are disclosed. The formulation is effective in inhibiting or killing the Proprionibacterium microorganism without utilizing antibiotics A preferred formulation alleviates the four pathogenic factors involved in the development of acne a) the putative pathogen of acne, Proprionibacterium acnes, b) abnormal desquamation of sebaceous-follicle epithelium (comedogenesis), c) the androgen-induced excessive sebum production, and d) the follicular reactivity (inflammation). The formulations are preferably applied as a cream, lotion or an emulsion.

The invention discloses an acne-removing composition and a preparation method thereof. The acne-removing composition can be absorbed by skins faster compared with an emulsion preparation so as to take the function to the maximum extent. The function of comprehensively removing acnes is achieved by means of improving the moisturizing effect of the skins, adjusting the grease balance of the skins, inhibiting hypersecretion of sebum and inhibiting reproduction of propionibacterium acnes as well as by virtue of interaction of anti-inflammatory action and acne removal. The pH of the acne-removing composition is 4.5-5.5 (10% aqueous solution) which is faintly acid, and the acne-removing composition is mild in property and does not irritate the skins, and meanwhile, the effects of macromolecular salicylic acid and a composite plant acne-removing preparation are more obvious.

The invention discloses an acne-removing cream containing Chinese herbal medicine extracts and a preparation method thereof, and aims to provide the acne-removing cream having stronger inhibitory effect on propionibacterium acnes, having good acne-removing effect, being safe and gentle and having no irritation on human bodies. The technical key point comprises that the acne-removing cream is prepared from the following components by the mass percentage: 6-10% of an emulsifier, 2-3% of a coemulsifier, 10-14% of grease, 0.4-0.6% of an antioxidant, 1.6-2.4% of an absorption enhancer, 5-7.5% of an acne-removing composition, 1.6-2.4% of an emulsifier thickener, 8-12% of a moisturizer, 0.2-1% of a preservative, and the balance water. With the total mass of the acne-removing composition as 100%, the acne-removing composition comprises the components by the mass percentage: 6-10% of camphor, 6-10% of menthol, 12-20% of a peony root extract, 28-40% of a rheum palmatum root extract, 20-30% of a Chinese gall extract and 8-12% of a cortex phellodendri amurensis extract. The acne-removing cream belongs to the technical field of skin care products.

The invention discloses an apple enzyme and a preparation method. The preparation method comprises the following steps: juicing apples, uniformly mixing apple juice with pure water, adding glucose which accounts for 1-5% of the total weight of the obtained raw material mixture into the raw material mixture that the volume percentage of the apple juice is 5-20%, adjusting the pH value to 5.0-7.0, sterilizing, preparing mixed bacteria from the obtained raw material liquid and a pichia pastoris bacterial liquid and a lactobacillus plantarum bacterial liquid in a volume ratio of 1:(1-5), controlling the temperature to 25-35 DEG C, performing primary fermentation for 12-48 hours, controlling the temperature of the obtained primary fermentation solution to 25-35 DEG C by using an acetic bacterial liquid, performing secondary fermentation for 12-36 hours, and sterilizing, thereby obtaining a finished product of the apple enzyme. Compared with a finished product of natural fermentation, the finished product of the apple enzyme disclosed by the invention has a remarkable antibacterial effect on propionibacterium acnes, and the removal rate IC50 of the apple enzyme on DPPH is 0.43%.

The invention discloses a polypeptide composition used for removing an acne and repairing the skin, the polypeptide composition comprises the following components by weight: 0.5-5 parts of antibacterial peptide, 0.01-3 parts of anti-inflammatory cytokine, 0.01-2 parts of a cell growth factor, 0-60 parts of a stabilizer, 0-40 parts of a humectant, 0-15 parts of an antioxidant, 0-30 parts of a solubilizer, and 800-950 parts of water. A product can effectively inhibit the propionibacterium acnes, the acne is fundamentally treated and prevented, the inflammatory reaction of the skin is effectivelyeliminated, the injured cell is repaired, the acne pit and the acne mark are effectively removed, and the product is non-irritant, is suitable for people suffering from skin allergy, and has the fundamental effects of removing the acnes and repairing the skin.

The invention relates to the technical field of cosmetics, in particular to a graphene mask and a preparation method thereof. Each 100 weight parts of the graphene mask is composed of: 0.1-8 parts ofgraphene, 0.05-5.2 parts of chitosan, 0-0.7 part of salicylic acid, 0.9-8.8 parts of gel, 0.1-2.9 parts of a honeysuckle extract, 0.1-3.5 parts of a dandelion extract, 0.1-2.5 parts of a salvia miltiorrhiza extract, 0.01-0.1 part of spice, and the balance water. According to the invention, graphene cooperates with chitosan, the honeysuckle extract, the dandelion extract and the salvia miltiorrhizaextract to serve as the main raw materials, the raw materials cooperate with each other for deep repair and treatment on skin comprehensively from the aspects of permeability, adsorption, antibacterial properties, oxidation resistance, repairability and the like, the graphene mask realizes quick and thorough elimination of propionibacterium acnes and thorough purification of pores, and is particularly effective on treatment of acne.

The invention discloses a botanical medicine composition with an acne removing effect and application. The botanical medicine composition is prepared from radix salviae miltiorrhizae, pomegranate bark, spreading hedyotis herb, rhizoma curcumae and licorice roots. The botanical materials are smashed, screened and mixed, the mixture is added into an extraction solvent and then soaked, room-temperature extraction is carried out with a high-pressure homogenization extraction machine, extraction liquor is subjected to centrifugal separation and then concentrated with a membrane, concentrated liquor is adsorbed with macroporous resin and then eluted repeatedly with ethanol, elution liquor is collected, butanediol is added for dissolution after membrane concentration, filtering is carried out, and the botanical medicine composition is obtained, wherein water or ethanol or an ethanol aqueous solution serves as the extraction solvent. The botanical medicine composition can inhibit secretion of skin grease, effectively inhibit propionibacterium acnes and achieve a good acne removing effect, and can enhance skin immunity, improve skin nature and make skin permeable, clean, smooth and fine when used for a long term.

The invention provides a preparation method of a probiotic and aloe mask, which is characterized by preparing a fermentation stock solution from aloe vera raw juice, glucose and water according to certain proportions and adding probiotics for performing co-fermentation. By setting different temperature gradients and pH gradients, after viable count, optimal fermentation conditions are determined; an aloe and probiotic fermentation solution is adopted to carry out an antibacterial test so as to determine an antibacterial effect, such as propionibacterium acnes; and meanwhile, by determining an antioxidant index, the antioxidant ability of the aloe and probiotic fermentation solution is determined, such as determination of DPPH radical scavenging ability, determination of iron ion chelating ability and determination of total reducing force. According to the product, the aloe and probiotic fermentation solution is mixed with cosmetic auxiliary materials in proportion so as to be processed into a pasty mask, and after sensory index testing, skin irritation testing and trial effect testing, the safety and functionality of the product are determined, so that the aims of skin protection and health care are achieved.

The invention relates to a composite microbial agent which is used for the sludge reduction of urban life sewage and industrial waste water treatment, which mainly contains photosynthetic bacterium colony, yeast bacterium colony, lactic acid bacterium colony, propionic acid bacillus colony, antinomycetes bacterium colony, fungus and the like which are beneficial to humans, animals and plants. By the specific culture mediums and culture technology, microorganisms with different anaerobic, facultative anaerobic and aerobic characteristics commonly live and exist in the same culture medium, and mutually benefit, compliment and cooperate. The production method adopts a microbiological fermentation method. The production steps comprise that strictly selecting microbial strains for production, slope storage, amplifying culture of seed liquid, product static state culture, vital cell counting, quality detection and packaging and storage. The production process of the agent has no 'three wastes' pollution, and belongs to 'clean production'. The agent does not contain any disease bacteria, and has no toxicity, harm and irritant.

The present invention relates to a composition for preventing and treating acne, comprising a material which has excellent antibacterial activity against Propionibacterium acnes known as acne-causing bacteria and which shows strong antibacterial activity against skin floras that enlarge the site of inflammation to worsen acne, in which the material also helps to regenerate skin cells damaged by acne. The composition comprises bee venom (collected from Apis meliffera) and is used the form of soap, cosmetic products, and medical products for skin application such as ointments, bands and dressings, which are used to fundamentally prevent and treat acne.

The invention relates to a recombinant yeast strain capable of producing conjugated linoleic acid and an application thereof. In the invention, codon optimization is carried out on linoleate isomerase in propionibacterium acnes (PAI) gene to obtain an optimized gene opai, recombinant expression plasmid and recombinant Yarrowia lipolytica bacterium which contain the opai gene are prepared, and therecombinant Yarrowia lipolytica bacterium which expresses the opai gene is utilized to produce conjugated linoleic acid.

Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.