98 results about "Propionibacterium acnes" patented technology

The application discloses a bacteriostatic and acne-removing microemulsion containing plant extracts and a preparation method thereof. The bacteriostatic and acne-removing microemulsion contains a microemulsion loaded with quercetin alone, a microemulsion loaded with sasanquasapernin alone, and a microemulsion loaded with quercetin and sasanquasapernin simultaneously. The bacteriostatic and acne-removing microemulsion containing plant extracts prepared by the application not only solves the problems of stickiness of camellia oil and poor solubility of quercetin, but also has a synergistic inhibitory effect on propionibacterium acnes, achieves the same high-efficiency bacteriostatic effect with a lower drug concentration, saves drug cost, reduces drug irritation, and expands the application of quercetin and sasanquasapernin in the cosmetic and pharmaceutical fields due to the rich pharmacological effect of the plant extracts, low side effect and safety. The microemulsion system prepared by the application is clear, transparent, uniform and stable, the preparation process is simple, the required energy is low, the cost is low, and the system is beneficial to commercial production.

The invention belongs to the technical field of biology, and particularly relates to an antibacterial peptide for inhibiting propionibacterium acnes and application of the antibacterial peptide. The antibacterial peptide for inhibiting propionibacterium acnes is derived from marine organism hylophila, and the amino acid sequence of the antibacterial peptide is shown as SEQ ID NO.1. The amino acid sequence is novel, has remarkable antibacterial activity on propionibacterium acnes, has the advantages of low hemolysis toxicity, low cytotoxicity and high safety, and can be used for preparing the antibacterial peptide for inhibiting propionibacterium acnes. Due to the characteristics, the compound has huge application potential in the aspect of treating acnes caused by propionibacterium acnes or removing acnes.

The invention relates to composite cosmetic nanoparticles with an acne removing effect and a preparation method of the composite cosmetic nanoparticles, and belongs to the technical field of functional skin care products and nano entrapment. According to the nano-particles, low-molecular chitosan is used as a main carrier, and natural multifunctional acne-removing components including a white willow bark extract, a tea catechin substance, a pomegranate peel extract and a hovenia dulcis thunb fruit extract are jointly embedded, so that a stable nano-particle structure with the particle size of 50-200 nm is formed; and sodium hyaluronate is used for surface modification so as to enhance skin adhesiveness and permeability. The multi-target synergistic active component can effectively inhibit the growth of propionibacterium acnes, relieve inflammatory response, regulate sebum secretion and enhance the antioxidant repair capacity of skin. The nano-particles prepared by the invention are concentrated in particle size distribution, high in entrapment rate and good in biocompatibility, are suitable for essence, spray, mask type and gel type acne-removing skin care products, and show excellent product transformation potential.

The invention belongs to the technical field of cosmetic raw materials, and particularly relates to a plant composition with oil control and acne removal effects and a preparation method and application thereof. The invention provides an oil-controlling and acne-removing plant composition. The oil-controlling and acne-removing plant composition is prepared from a rheum palmatum extract, a scutellaria baicalensis extract, a radix sophorae flavescentis extract, a safflower extract, a campsis grandiflora extract, a chrysanthemum extract, a cockscomb extract and a rose extract in a specific proportion. Through synergistic compatibility of eight plants, the plant composition can effectively inhibit grease synthesis, inflammatory factor expression and propionibacterium acnes growth, so that good oil control and acne removal effects are achieved.

This invention relates to compositions (e.g. immunogenic compositions) which can be used to immunise against C. acnes. The compositions comprise C. acnes antigens and antigen combinations, used in the form of nucleic acids (e.g. mRNAs) encoding antigenic proteins or in the form of recombinant protein antigens.

The present application relates to a kind of plant anti-dandruff composition with oil control and bacteriostasis efficacy and application thereof, belong to the field of cosmetics.The composition includes soapberry fruit extract, camellia seed extract, artemisia annua extract, valerian root extract, phyllanthus emblica fruit extract;The valerian root extract is extracted after being inoculated with mixed inoculant consisting of bacillus licheniformis and lactobacillus bulgaricus and then fermented with valerian root as raw material.The valerian root extract obtained by the fermentation of specific strains and strain ratio mixture is significantly improved in the bacteriostatic effect on malassezia and propionibacterium acnes.Further, the present application selects specific soapberry fruit extract, camellia seed extract, artemisia annua extract, phyllanthus emblica fruit extract and the obtained valerian root extract within a specific proportion range, and the obtained composition has synergistic effect of each component, which can significantly improve its oil control, bacteriostasis and anti-dandruff effect.

This invention provides ozenafloxacin nanocrystalline particles, its preparation method, and its uses. The preparation method includes the following steps: dissolving ozenafloxacin raw material in an acidic aqueous solution, then adding a stabilizer, stirring, and adjusting the pH to 4-6; wherein the stabilizer is a siloxane and / or a cellulose derivative. The preparation method provided by this invention can obtain ozenafloxacin nanocrystalline particles with uniform and stable particle size distribution. Further research by the inventors has found that formulations containing these ozenafloxacin nanocrystalline particles can increase the amount of drug retained in the skin, thereby increasing the local drug concentration, achieving effective killing of Propionibacterium acnes, and preventing the development of drug resistance.

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

The invention discloses an oil-controlling, soothing and repairing composition and a preparation method thereof. The oil-controlling, soothing and repairing composition is prepared from a herba portulacae extract, a herba centellae extract, a baropetalum chinense leaf extract and a plankton extract. According to multiple experimental researches, the composition obtained by compounding the extracts has excellent effects of controlling oil, inhibiting activity of propionibacterium acnes, relieving and repairing, is mild and non-irritant, and has a good popularization and application prospect.

This invention discloses an anti-acne Propionibacterium acnes compound essential oil, its preparation method, and its application. The anti-acne Propionibacterium acnes compound essential oil is composed of the following components in the indicated mass percentages: 22%~28% helichrysum essential oil, 22%~28% sweet basil essential oil, 22%~28% eucalyptol rosemary essential oil, and 22%~28% true lavender essential oil. This invention achieves highly effective antibacterial activity against Propionibacterium acnes through a precise selection of four plant essential oils and a scientifically formulated compound. It also possesses multiple benefits including anti-inflammatory properties, promotion of skin cell regeneration, and a natural fragrance. Furthermore, the product is natural, safe, and has no side effects, is suitable for various skin types, and can be directly applied to the preparation of various acne-removing skincare products.

The invention relates to the field of cosmetic raw material development and cosmetics, in particular to a cosmetic composition containing oxidoreductase as well as a preparation method and application of the cosmetic composition. The composition is prepared from the following components in parts by weight: 1.5 to 3.5 parts of oxidoreductase, 0.3 to 2.5 parts of aloe barbadensis leaf extract, 0.5 to 3 parts of pimpinella diversifolia fruit extract, 0.6 to 4 parts of lysozyme, 0.8 to 2.5 parts of papain, 0.5 to 1.8 parts of lysozyme, 0.5 to 3.5 parts of pansy extract and 0.5 to 3 parts of amur corktree bark extract. The composition prepared by the invention has excellent efficiency of inhibiting propionibacterium acnes and elastinase, and has the effects of removing acnes, tightening skin and resisting aging; the composition uses active components for moisturizing, anti-inflammation, sterilization and the like, and also has good effects of sensitive repair and skin micro-ecology regulation.

The invention relates to a composition, a mask and application thereof. The invention particularly relates to a composition which comprises a functional material and a spinning matrix, the functional material comprises a black willow bark extract and a hydrogen storage material, and relative to the total mass of the composition, the mass fraction of the black willow bark extract is 0.130%-0.210%, and the mass fraction of the hydrogen storage material is 0.05%-0.20%; the mass fraction of the spinning matrix is 8%-20%. The composition can control grease secretion, improve facial grease accumulation, reduce the number of acnes of a subject, fade acne marks, inhibit growth of propionibacterium acnes and improve acnes.

The invention relates to a propionibacterium acnes selective culture medium and a preparation method thereof, the culture medium comprises casein pancreatin digest, meat and stomach enzyme digest, heart and pancreatin digest, yeast extract powder, corn starch, sodium chloride, agar and defiberized sheep blood, and the volume is fixed with distilled water. Compared with an existing culture medium, the culture medium has the advantages of being reliable in detection and high in propionibacterium acnes separation rate and has a good application prospect.

This invention relates to the field of plant extract application technology, particularly to banana fruit extract and its applications. This invention reveals that banana fruit extract exhibits excellent performance in relieving inflammation, anti-oxidation, scavenging free radicals, delaying cell aging, inhibiting viruses and bacteria (inactivating HPV, Staphylococcus aureus, Candida albicans, Escherichia coli, and Propionibacterium acnes), reducing infection, promoting cell regeneration and repair, promoting collagen synthesis, enhancing elasticity and firmness, and acting as a plant-derived immunomodulator. Furthermore, it serves as a natural, intelligent transdermal carrier. Safe and non-irritating, this extraction method has shown excellent application value in high-value plants such as saffron, rose, Dendrobium officinale, ginseng, and Ganoderma lucidum. It provides a comprehensive solution for skin from defense to regeneration, offering a regulatory-compliant natural solution for functional skincare.

The application relates to the technical field of biological medicine, in particular to a compound with a conjugated structure containing an alpha, beta-unsaturated aldehyde and application thereof. The compound can covalently modify Sortase A enzyme of propionibacterium acnes through alpha, beta-unsaturated aldehyde, inhibit transpeptidation catalysis and adhesion of gram-positive bacteria (for example, methicillin-resistant staphylococcus aureus, streptococcus mutans and propionibacterium acnes), block anchoring of membrane proteins, inhibit growth of gram-positive bacteria or kill bacteria; conjugated groups with different electric effects and steric effects are screened to adjust the covalent modification efficiency of alpha, beta-unsaturated aldehyde and Sortase A enzyme, strengthen the activity of the compound in inhibiting Sortase A enzyme, thereby improve the antibacterial activity of the compound, and further make the compound with the conjugated structure containing the alpha, beta-unsaturated aldehyde in the application be applied to the fields of biological medicine and cosmetics as an antibacterial component.

The invention relates to the technical field of natural product chemistry and cosmetics, and particularly discloses application of a composition containing a radix salviae miltiorrhizae extract in preparation of a product with an acne removing effect. The composition containing the radix salviae miltiorrhizae extract comprises the radix salviae miltiorrhizae extract and a calendula officinalis extract, the radix salviae miltiorrhizae extract is obtained by extracting with an ethanol water solution; the calendula officinalis extract is extracted by a carbon dioxide supercritical extraction method. Researches show that the composition containing the salvia miltiorrhiza extract, which is obtained by combining the salvia miltiorrhiza extract prepared by the method and the calendula officinalis extract, has a certain antibacterial effect on propionibacterium acnes. Therefore, the composition has important application value when being used as an active ingredient for preparing the medicine or the cosmetic with the acne removing effect.

This invention relates to the field of antibacterial product technology, specifically to a plant composition with antibacterial effects, its preparation method, and its application. The plant composition, by weight, comprises the following raw material components: 2-6 parts of Lophatherum gracile, 2-5 parts of Rhodomyrtus tomentosa, 1-5 parts of Phellodendron amurense, and 2-8 parts of Podocarpus macrophyllus. The plant composition of this invention has the advantages of good efficacy and no side effects in inhibiting Staphylococcus aureus, Escherichia coli, Candida albicans, Malassezia furfur, and Propionibacterium acnes.

The application belongs to the technical field of natural plant extracts and application, and particularly relates to azafran volatile oil and application thereof in preparation of antifungal bacteriostatic products. In the application, the azafran is soaked in water and then distilled to obtain azafran volatile oil. The obtained azafran volatile oil shows good bacteriostasis, especially in inhibiting fungal strains such as Candida albicans, Malassezia furfur, Trichophyton mentagrophytes and Propionibacterium acnes. The application develops a new use of azafran volatile oil in preparation of antifungal bacteriostatic products.

The invention belongs to the technical field of medicines and the field of acne treatment, and particularly relates to application of amorphous salt in preparation of a medicine for treating acne and the medicine. The amorphous salt is prepared by reacting ursodesoxycholic acid and matrine, preferably, the ursodesoxycholic acid and the matrine are dissolved in a proper solvent according to the molar ratio of 1: (0.5-2), then the solvent is rapidly removed, and remaining solids are further dried and crushed to obtain the ursodesoxycholic acid / matrine amorphous salt. The solubility and the percutaneous penetration rate of the propionibacterium acnes are remarkably improved, the propionibacterium acnes can be inhibited, the expression of IL-1beta, IL-6, IL-8 and TNF-alpha can be reduced, P65 protein nucleus translocation can be inhibited, and an efficient and safe new scheme is provided for acne treatment.

The invention provides a phenolic amide derivative and application thereof, relates to application of a compound and a composition thereof in preparation of cosmetics or medicines for preventing, treating and relieving acne, and provides a medicine or cosmetic composition which comprises a therapeutically effective amount of compound, or at least one of a racemate, a stereoisomer, a geometric isomer, a tautomer, an isotope label, a hydrate, a solvate, a polymorphic substance, a metabolite, a prodrug and pharmaceutically acceptable salt or ester. The present invention provides the prevention, treatment or alleviation of skin problems associated with Propionibacterium acnes, including comedo, acne, folliculitis; according to the phenolic amide derivative with a novel structure, the structural type of the phenolic amide compound is enriched, the activity of inhibiting propionibacterium acnes is increased on the basis of retaining the anti-inflammatory activity of the phenolic amide compound, and the aim of treating both symptoms and root causes of skin problems related to the propionibacterium acnes is achieved.

The invention discloses a bifidobacterium animalis subsp. Lactis BT-G9 with a growth promoting function and application of the bifidobacterium animalis subsp. Lactis BT-G9, the bifidobacterium animalis subsp. Lactis BT-G9 is preserved in China Center for Type Culture Collection, the preservation date is November 20, 2025, and the preservation number is CCTCC NO: M 20252626. The brand new bifidobacterium animalis subsp. Lactis BT-G9 provided by the invention has good tolerance to gastric juice and intestinal juice, is suitable for survival in gastrointestinal tracts, can effectively inhibit bacteria, and particularly can effectively inhibit campylobacter kirscheri, streptococcus agalactiae and / or propionibacterium acnes. Experimental results show that the strain can promote animal growth and development and improve the autism, especially when the animal bifidobacterium subsp. Lactis BT-G9 and the lactobacillus acidophilus BT-C15 are combined for use, the animal bifidobacterium subsp. Lactis BT-G9 and the lactobacillus acidophilus BT-C15 have a synergistic effect, and the improvement effect on the autism can be remarkably improved. In addition, the extracellular vesicles prepared from the strain can effectively repair the skin barrier function.

The present invention relates to a combination comprising an extract of Myrtus communis and an extract of Tripterygium wilfordii, in particular for the treatment of inflammation caused by Propionibacterium acnes and for the treatment of acneic skin.

The present application provides a kind of epidermis repair gel dressings and its preparation method, it is related to dressing field.The epidermis repair gel dressings includes repair liquid, 100 parts of the repair liquid includes composite sodium hyaluronate 0.1-0.3 parts, carbomer 0.02-0.06 parts, glycerol 1-4 parts, pentanediol 1-3 parts, composite acid 0.05-0.1 parts, composite peptide 0.01-0.03 parts and the balance purified water by weight parts;The composite sodium hyaluronate is composed of sodium hyaluronate, hydrolyzed sodium hyaluronate and sodium hyaluronate crosslinked polymer;The composite acid is prepared from ursolic acid, hydroxyl asiatic acid, lipoic acid;The composite peptide is prepared from thirteen peptides and palmitoyl pentapeptide-3.The epidermis repair gel dressing of the present application has better repair effect on acne lesions, not only inhibits active propionibacterium acnes, but also can reduce the expression of inflammatory factors, can deeply repair damaged basal structure, maximumly reduce the degree of acne lesions, and restore to close normal skin.

The application discloses a targeted acne-removing composition suitable for sensitive skin and a preparation method and application thereof. The targeted acne-removing composition comprises lysozyme, a first extract and a second extract in a mass ratio of 1:(0.1-10):(0.1-5). The first extract comprises guaiacum extract and myrtle fruit extract. The second extract comprises sophora flavescens extract and angelica sinensis extract. The targeted acne-removing composition containing lysozyme, the first extract and the second extract in specific mass ratios can inhibit the activity of propionibacterium acnes, down-regulate the expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4), and achieve efficient acne removal, and has the mild property and can be suitable for sensitive skin.

The present application belongs to the technical field of skin care products, and particularly relates to a plant compound cleansing jelly with oil control and acne removal effects and a preparation method thereof. An amino acid surfactant compound system is adopted to effectively remove excess facial oil and dirt while causing little damage to the skin barrier and having no tight feeling after washing, thus solving the problem of'more oil after washing' caused by excessive defatting of traditional soap-based cleansing products. By compounding Lonicera japonica flower extract with plant extracts such as Sophora flavescens, Scutellaria baicalensis and Hamamelis virginiana and PCA zinc, synergistic effects are produced in terms of inhibiting sebum secretion (oil control), inhibiting Propionibacterium acnes (acne removal) and reducing inflammatory reactions (anti-inflammatory), and compared with single components or simple combinations, the effects are more comprehensive and longer-lasting. In addition, the product provided by the present application is in the form of jelly, is refreshing and not sticky, is easy to rinse, and is suitable for daily use of oily and mixed oily skin.

Biomimetic, prebiotic, probiotic, and postbiotic compositions, and methods of using them, are disclosed. The biomimetic, prebiotic, probiotic, and postbiotic compositions may include bacteria of the genus C. acnes, cultures thereof, and / or components thereof, and / or substances that induce the growth or activity of C. acnes. The biomimetic, prebiotic, probiotic, and postbiotic compositions can be used to prevent, ameliorate, and / or treat conditions such as atopic dermatitis.

The present application belongs to the technical field of skin care products, and particularly relates to a composition for treating acne and a preparation method thereof. The composition comprises the following components: 1-2% of a lactic acid bacillus fermentation product, and 5-8% of a plant extraction component; the plant extraction component is composed of a Pinus Nigra Leaf Extract, a Osmorhiza Aristata Root Extract, and a Echinacea Purpurea Extract. The mass ratio of the Pinus Nigra Leaf Extract, the Osmorhiza Aristata Root Extract, and the Echinacea Purpurea Extract is 1:(1-3):(5-10). The Osmorhiza Aristata Root Extract, the Pinus Nigra Leaf Extract, and the Echinacea Purpurea Extract have a certain synergistic effect in the composition formula, and therefore, the acne treatment composition provided by the present application can effectively inhibit the growth of Propionibacterium acnes, reduce the occurrence of skin inflammation, effectively treat acne, and has a good market application prospect.

The invention discloses torreya grandis seed oil and application thereof, and belongs to the field of plant extracts. The torreya grandis seed oil is prepared by adopting a supercritical CO2 extraction method, the expression level of a macrophage RAW264.7 inflammatory factor IL-6 caused by LPS can be remarkably reduced, and the torreya grandis seed oil has a good anti-inflammatory effect. The traditional Chinese medicine composition disclosed by the invention can effectively inhibit the growth of propionibacterium acnes, also can effectively regulate the skin flora balance of people with acnes, has no obvious influence on the growth of staphylococcus epidermidis while remarkably inhibiting the growth of propionibacterium acnes, is an excellent acne-removing cosmetic raw material, and has a wide application prospect in the development of nursing products for people with acnes.

The present application relates to the technical field of biological medicine, in particular to a traditional Chinese medicine composition for improving acne and application, which is made of medicinal raw materials including a first component, a second component and a third component, wherein the first component includes 25-35 parts of white yam, 25-35 parts of hawthorn, 25-35 parts of salvia miltiorrhiza, 13-17 parts of gardenia, and 8-12 parts of white peony; the second component includes 25-35 parts of nacre, 13-17 parts of tribulus terrestris, and 8-12 parts of safflower; and the third component includes 13-17 parts of raw rhubarb, 8-12 parts of gallnut, 8-12 parts of turmeric, 3-7 parts of ganoderma lucidum, and 3-7 parts of winter nightshade. The traditional Chinese medicine composition has the dual effects of inhibiting propionibacterium acnes and anti-inflammation, and especially, the whole composition shows a significant synergistic effect in anti-inflammation in vivo, which is better than each component alone or any two components in combination. The composition can be prepared into oral or external medicines for preventing, relieving and treating various types of acne, and can also improve post-acne pigmentation and post-acne scarring, and has a good application prospect with a significant clinical effect and high safety.