29 results about "Periodontitis" patented technology

The application discloses a kind of solid teeth pain-relieving and inflammation-clearing traditional Chinese medicine composition, it is related to traditional Chinese medicine product technical field.The composition is composed of gypsum, raw rehmannia, coptis, talc, ocher, radix cyathulae and salvia miltiorrhiza seven raw medicinal materials, wherein gypsum, raw rehmannia are monarch drug, clear and purge stomach fire, cool blood and nourish yin;Coptis, talc are ministerial drug, clear heat and dry dampness, lead heat down;Ocher, radix cyathulae are auxiliary drug, heavy town counteract, lead fire down;Salvia miltiorrhiza is servant drug, promote blood circulation and remove blood stasis, promote tissue repair.Modern pharmacological research shows that each drug of the present party has the effects of anti-inflammatory, analgesic, antibacterial, improving microcirculation and protecting periodontal tissue etc.Clinical observation shows that the pain of most patients caused by stomach fire attacking upward, gum redness and swelling, burning pain, bleeding is significantly reduced after taking 1-2 doses, redness and swelling gradually subside.Compared with existing Chinese patent medicines, the present application is simple in prescription, low in cost, has the dual effects of rapid pain relief and long-term tooth fixation, and is especially suitable for patients with recurrent toothache and early periodontitis.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

This invention discloses a near-infrared light-exciteable composite nanosheet, its preparation method, and its applications, belonging to the field of biomedical technology. The method includes the following steps: mixing epigallocatechin gallate with a Ti3C2 nanosheet dispersion, ultrasonically reacting, adding silver salt, and continuing stirring in the dark; after the reaction is complete, washing and separating to obtain MXene-EGCG@Ag composite nanosheets. The composite nanosheets provided by this invention possess near-infrared light-exciteable properties and can be used to prepare medically acceptable dosage forms such as hydrogels for the treatment of periodontitis. The preparation method provided by this invention is simple, the raw materials are readily available, and it exhibits significant antibacterial and anti-inflammatory effects, enabling further widespread application.

This invention belongs to the field of oral care technology and provides a bismuth microsphere oral care agent that eliminates halitosis and has anti-inflammatory and antibacterial properties. The agent comprises a bismuth complex, wherein the bismuth complex is a porous bismuth microsphere selected from Bi2O2CO3 and Bi2O2CO3@Bi2S3 heterojunctions. This oral care agent can rapidly respond to the high expression of H2S in periodontitis, eliminating halitosis, inhibiting inflammation, and regulating the periodontal microenvironment. Simultaneously, the (Bi2O2CO3) microspheres react with H2S to form Bi2O2CO3@Bi2S3 heterojunctions in situ, which can efficiently kill bacteria under light irradiation.

The present invention relates to a composition for preventing or treating periodontitis containing cannabidiol and taurine. The composition according to the present invention can effectively prevent or treat periodontitis by suppressing inflammatory factors and directly suppressing the loss of alveolar bone. In addition, it is safe for the human body and has almost no side effects, so it can be used in various ways as a material for medicines, quasi-drugs, or health functional foods.

This invention relates to the field of biomedical technology, specifically disclosing an anti-inflammatory and bone-promoting rhodioloside composite hydrogel and its preparation method. The thermosensitive carrier is a triple-response system, which enhances the drug release rate only in a specific microenvironment at 37°C, with a pH of 5.5-6.5 at the site of inflammation, and in which MMPs are overexpressed. MMPs are highly expressed at the implant periodontitis site, and MMP-sensitive peptides can be specifically degraded by this enzyme. This process can trigger the precise release of rhodioloside and quercetin active ingredients in the gel, avoiding systemic drug diffusion that could lead to drug waste or side effects at other sites. Rhodioloside and quercetin synergistically downregulate the expression levels of inflammatory factors such as IL-6 and TNF-α, while nisin and chitosan-ε-polylysine grafts inhibit the growth of Porphyromonas gingivalis. Runx2 / CON expression is increased, achieving a closed-loop treatment of anti-inflammatory, antibacterial, and bone-promoting effects.

This invention relates to the field of medical device technology and provides a flexible self-powered oral diagnostic and treatment device and its preparation method. The device includes a flexible conductive porous microneedle, a flexible microfluidic module, a flexible triboelectric nanogenerator, and a flexible transparent dental crown. The flexible conductive porous microneedle is used to extract gingival crevicular fluid, and its surface has multiple rings of needles at different heights. The flexible microfluidic module incorporates a microchannel structure and a detection unit to analyze biomarkers in the gingival crevicular fluid. The flexible triboelectric nanogenerator converts the mechanical energy of oral motion into electrical energy to provide exogenous electrical stimulation and achieve electrically controlled drug release. This device enables real-time monitoring, diagnosis, and treatment of the oral microenvironment, and has advantages such as self-powered operation, good fit, and discreet comfort, making it suitable for closed-loop management of oral diseases such as periodontitis.

The application belongs to the technical field of anti-inflammatory and specifically relates to a pH-sensitive self-assembled PACs@ZIF-8 nano temperature-controlled slow-release system, a preparation method and application thereof. The pH-sensitive self-assembled PACs@ZIF-8 nano temperature-controlled slow-release system provided by the application comprises a hydrogel matrix and PACs@ZIF-8 nanoparticles wrapped in the hydrogel matrix; the PACs@ZIF-8 nanoparticles comprise ZIF-8 nanoparticles and procyanidins loaded on the ZIF-8 nanoparticles. The application not only can exert the response release of ZIF-8 in an acidic microenvironment, improve the stability of PACs and solve the problem of poor bioavailability, but also realizes local forming and long-acting slow release by using the hydrogel matrix, thereby synergistically enhancing the treatment advantages of PACs. The system provided by the application plays a role in anti-inflammatory and antioxidant and provides a new treatment method for the treatment of periodontitis.

The present application relates to the technical field of biological materials, and particularly relates to a preparation method of a two-stage microneedle for regulating reactive oxygen species homeostasis and application thereof.The present application combines two complementary materials of Fe-MOF for oxidative antibiosis and CeO2 for ROS removal to construct a two-stage microneedle for regulating reactive oxygen species, which can not only realize local delivery of drugs, but also effectively treat periodontitis through antibiosis, ROS balance and bone promotion.The present application utilizes Fe-MOF and CeO2 nanomaterials to synergistically regulate ROS level, Fe-MOF catalyzes Fenton-like reaction to generate ROS in the periodontal pocket microenvironment, realizes efficient, rapid and broad-spectrum antibiosis, and compared with traditional antibiotics, can reduce the risk of drug resistance, while CeO2 has excellent antioxidant enzyme simulation activity, removes excess ROS and reduces inflammatory response, and the innovative combination of the two materials solves the core contradiction between efficient antibiosis demand and oxidative stress damage in the treatment of periodontitis.

This invention provides a combination of medicine and device for treating dental diseases. The method for preparing the medicine is as follows: Boil 1 dan (approximately 50 catties) of cocklebur root and stems, 30 jin (approximately 15 catties) of wild chrysanthemum stems and leaves, and 5 jin (approximately 2.5 kg) of licorice root in a pot until thoroughly cooked. Remove the dregs, and bring the remaining liquid to a boil over high heat, then simmer over low heat until it becomes a paste. When the paste is about 70% cooked, for the treatment of gingivitis and periodontitis, add 100g of indigo naturalis, 50g of mirabilite, 150g of borax, 100g of gypsum, and an appropriate amount of edible preservative. Set aside when fully cooked. For the treatment of toothache, when the paste is about 70% cooked, add 50g of asarum, 100g of angelica dahurica, 100g of Sichuan pepper, 50g of bee honeycomb, 50g of rosin, 100g of borax, 50g of gypsum, and an appropriate amount of edible preservative. (These herbs should be pulverized before being added.) Set aside when fully cooked. The treatment device is a long, narrow, isosceles trapezoid with a hollowed-out center and top base, leaving a wall thickness of 0.2-0.4 mm. The device's dimensions are: base 13 mm, sides 13 mm, and length 18 mm. It can be made of metal or non-toxic plastic. A strip of cloth of the corresponding size is attached to the device, and the prepared ointment is applied to the cloth. When using it, the ointment-coated device is placed on the affected area, ensuring close contact with the lesion and maximizing the medication's effectiveness.

This invention relates to the field of antimicrobial peptide technology, specifically to an antimicrobial peptide for maintaining oral flora balance, its preparation method, and its application. The antimicrobial peptide for maintaining oral flora balance according to this invention includes any one of the following polypeptides (a)-(e): (a) a polypeptide whose amino acid sequence includes the amino acid sequence shown in SEQ ID NO. 1; (b) an amino acid sequence composed of amino acid residues shown in SEQ ID NO. 1; (c) a polypeptide formed by substituting and / or deleting and / or adding one or more amino acid residues to the amino acid sequence defined in (a) or (b); (d) a polypeptide having 99% or more, 95% or more, 90% or more, 85% or more, or 80% or more homology to the amino acid sequence defined in (a) or (b); (e) a polypeptide obtained by modifying the N-terminus and / or C-terminus of any one of the polypeptides defined in (a)-(d). The antimicrobial peptides of this invention, used to maintain oral flora balance, exhibit antibacterial and bactericidal activity against oral pathogens while not affecting the normal growth of beneficial bacteria. This balance is maintained, protecting gum health and freshening breath. These antimicrobial peptides are suitable for preparing oral antibacterial agents and related oral care products, regulating the balance of the oral microecology, and thus used to prevent and treat oral diseases, especially dental caries, periodontitis, oral mucosal diseases, and oral cancer. The antimicrobial peptides of this invention are relatively short, making chemical synthesis easier and allowing for direct synthesis into high-purity products. They also exhibit clear effects and have wide applications.

This invention belongs to the field of biomedical technology, specifically disclosing the application of cimicifuga in the preparation of drugs for treating periodontitis. Specifically, it relates to the application of cimicifuga in the preparation of drugs for treating periodontitis; and the application of cimicifuga in the preparation of drugs for treating alveolar bone defects (periodontal bone defects) caused by periodontitis. It also relates to the application of cimicifuga in the preparation of products for inhibiting macrophage polarization towards M1 and / or promoting macrophage polarization towards M2 in a single macrophage system. In this disclosure, cimicifuga has no significant toxicity to macrophages and has high safety; it targets and regulates macrophage polarization, inhibiting periodontal inflammation at its source; it significantly reduces inflammatory infiltration and osteoclast formation in periodontal tissues, effectively alleviating alveolar bone defects; and it provides a novel targeted immunotherapy drug for periodontitis, expanding the clinical application of single traditional Chinese medicine monomers.

The invention relates to a diagnostic microarray device comprising: a substrate, preferably formed of a glass material; wherein a plurality of probes attached or otherwise associated with the substrate, each probe being specific to one allele of a single nucleotide polymorphism (SNP), said SNR being selected from the group consisting of IL1B+3877, IL1B-511, and IL6-1363, and preferably IL10-592, CD14-260 and COX2+8473.

This invention belongs to the interdisciplinary field of natural product medicinal chemistry and oral medicine, specifically disclosing the application of uvangoletin in the preparation of anti-periodontalgia drugs. Uvangoletin is 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-1-propanone, with the molecular formula C. 16 H 16 O4, experiments confirmed that its MIC for Porphyromonas gingivalis was 16 μmol / L, MIC 50 The concentration is 10.28 μmol / L, the MIC for Fusobacterium nucleatum is 16 μmol / L and the MIC50 is 6.86 μmol / L. It has no inhibitory activity against Streptococcus mutans and has selective anti-periodontal pathogenic bacteria characteristics. It can be made into oral preparations such as gels, mouthwashes or toothpaste.

The application discloses a hollow zinc oxide / polylactic acid piezoelectric nanofiber dressing for oral mucosa wound repair and a preparation method thereof. The dressing takes polylactic acid nanofiber as a matrix, embeds hollow zinc oxide in the matrix, and introduces surface charges through high-voltage corona polarization treatment. The dressing can convert the mechanical energy of oral movement into local bioelectricity and biochemical signals under external stimulation such as mechanical movement of the oral cavity or low-intensity pulsed ultrasound, and release active oxygen and zinc ions with antibacterial and redox activity, and is suitable for auxiliary repair of oral mucosa defects such as oral ulcer, periodontitis postoperative care and large-area trauma defects, and has a good application prospect.

This invention provides a computer-aided analysis system based on high-throughput sequencing data and knowledge graphs, including a data access agent, a quality control analysis agent, a species annotation agent, a knowledge graph reasoning agent, a report generation agent, and an agent scheduling center. The data access agent acquires sequencing data and clinical phenotypic data; the quality control analysis agent performs quality control using the Illumina NovaSeq platform, V3-V4 primers, the SILVA v144 database, Q30 ≥ 90%, and sequences ≥ 50 bp; the species annotation agent performs species classification annotation based on a reference database; the knowledge graph reasoning agent performs association analysis based on a microbiome-disease-intervention knowledge graph, using ET_MGNN and RTGN models, including 264 search keywords covering dental caries, periodontitis, oral cancer, Alzheimer's disease, diabetes, and heart disease; the report generation agent generates personalized analysis reports and intervention suggestions; and the agent scheduling center manages and dynamically schedules all agents, forming a complete closed loop of "perception → analysis → diagnosis → intervention → execution → feedback".

The invention discloses application of recombinant human glaze matrix protein in preparation of an anti-periodontitis oral care product. The oral care product is prepared from rhEMPs, glycerin, sorbitol, poloxamer 188, sodium lauroyl sarcosinate, potassium nitrate, sucralose, xylitol, methylparaben, propylene glycol, PEG-40 hydrogenated castor oil, domiphen and water. The core innovation of the oral care product is that the stability bottleneck of rhEMPs in the physiological pH environment of the oral care product is solved by utilizing the synergistic stabilization effect of poloxamer 188 and sodium lauroyl sarcosinate, and it is found that when the oral care product is combined with components such as potassium nitrate, periodontal pathogenic bacteria can be remarkably inhibited, gingival inflammation can be relieved, and periodontal tissue repair can be promoted. The product form can be mouth wash, oral spray or toothpaste, the preparation process is simple, the stability is good, and a brand new solution is provided for daily adjuvant therapy of periodontitis.

The application provides a supramolecular complex and a preparation method and application thereof, and belongs to the field of biological medicines. The supramolecular complex is prepared from raw materials in the following mass ratio: the mass ratio of puerarin to collagen or a complex thereof is 1:(0.5-20), or the mass ratio of an antibacterial peptide, puerarin and collagen or a complex thereof is 1:5:(2.5-100); the supramolecular complex can form a hydrogel. The supramolecular complex and the hydrogel thereof have significantly improved permeability, can effectively penetrate deep tissue and cells of gingival epithelium, deliver drugs into inner layers of tissue and cells, realize efficient clearance of intracellular pathogens, and break through the problem of insufficient clearance of intracellular bacteria in the existing periodontal drug delivery system. Meanwhile, the supramolecular complex has excellent antibacterial and anti-inflammatory properties and bone formation promoting ability, can effectively treat periodontitis, and provides a new integrated solution for periodontitis treatment.

This invention discloses a method for co-loading baicalin and Ca 2+ This paper describes a ROS-responsive in-situ photosensitive gel, its preparation method, and its applications, including a phospholipid membrane-encapsulated composite of baicalin and calcium carbonate nanoparticles, and a ROS-responsive gel matrix. This photosensitive gel exhibits high adhesion, ROS-responsive drug release, in-situ photosensitized curing, and the ability to release baicalin and calcium carbonate nanoparticles. 2+ Its advantages, such as synergistic therapy, have significantly improved the treatment effect of periodontitis, providing new drug carriers and treatment options for the clinical treatment of periodontitis.

The application relates to the field of biological medicine, and particularly relates to application of a curcumin compound in preparation of a medicine for treating periodontitis, and comprises the following steps: a mono-carbonyl curcumin analogue with a structure shown in formula (I) is used for preparing the medicine for treating periodontitis, and the compound is obtained by replacing a beta-diketone group of natural curcumin with a mono-carbonyl connecting group. The compound provided by the application has a chemical stability which is significantly better than that of natural curcumin, and solves the problems of easy degradation and low bioavailability; meanwhile, the compound has excellent broad-spectrum anti-periodontal pathogenic bacteria activity and immune regulation capacity, can significantly promote M2 phenotype polarization of macrophages and inhibit generation of key pro-inflammatory cytokines, realizes double effects of antibiosis and immune regulation, and provides a new, efficient and low-toxicity auxiliary treatment medicine for periodontitis.

The application discloses a kind of sequence optimization combined with high-efficiency preparation method of recombinant human enamel matrix protein of affinity chromatography, belong to the field of bioengineering technology, and preparation method includes the following steps: construction expression strain: remove signal peptide and the human enamel matrix protein gene of codon optimization is connected with expression plasmid, constructs recombinant plasmid, and is transformed into expression host bacteria, obtains recombinant strain;Induction expression;Affinity chromatography purification;Tag is removed by enzyme cutting: the fusion protein of preliminary purification is cut using specific protease to remove the label;Refine pure.The application solves the problems of low expression level of recombinant enamel matrix protein, complex purification process and high cost by the innovation of sequence optimization and purification process, the prepared protein is high in purity, high in yield, and has significant anti-periodontitis activity, and is suitable for the development of drugs, oral care products and skin care products.

This invention provides a method and electronic device for generating periodontitis reports based on dual-energy CBCT. The method includes: acquiring high- and low-energy dual-energy CBCT projection data, an intraoral 3D scanning model, and structured electronic medical record data of the patient; reconstructing high- and low-energy CBCT volumetric images; obtaining image quantification features and quantification indicators; aligning and fusing the image quantification features with clinical features in the intraoral 3D scanning model and electronic medical record data at the tooth position level to obtain staging results; calculating a consistency coefficient; when the consistency coefficient is lower than a preset threshold, triggering a conflict alarm and automatically adjusting the evidence weight in the final staging decision to obtain conflict detection results; and automatically generating a structured diagnostic report based on the quantification indicators, staging results, and conflict detection results. This aims to improve diagnostic accuracy in complex oral environments.

This application discloses the application of Fe / Mn bimetallic enzymes in the preparation of anti-periodontalgia or teeth whitening agents. The Fe / Mn bimetallic enzyme exhibits excellent photothermal properties and peroxidase-like activity; that is, under photothermal synergy, its POD-like activity can be significantly enhanced, generating more ·OH groups. In antibacterial coating experiments against *Porphyromonas gingivalis* and drug-resistant *Staphylococcus aureus*, Fe / Mn BA, through photothermal synergistic chemokinetic therapy, achieved antibacterial rates exceeding 90%. By treating periodontitis through anti-inflammatory and antibacterial action and achieving teeth whitening through pigment degradation, the application of this biatomic nanozyme provides a new research direction for the application of artificial enzymes in oral diseases and is expected to open up broader pathways to address the challenges currently faced by artificial enzyme antibacterial technologies.

The present application provides the use of methylcatester for treating periodontitis. The present application also provides a method for preparing a sustained-release drug film containing methylcatester. The sustained-release drug film provided by the present application can inhibit the release of inflammatory factors, inhibit bacterial adhesion, and has a sustained-release time of up to the seventh day, has obvious effect on anti-periodontitis, and can effectively reduce the pathological changes of periodontal tissue.

1. Name of the product in this design: Test tube. 2. Purpose of this design: To detect bacteria on the periodontium and assess the degree of periodontitis. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention discloses an injectable hydrogel for photothermal-assisted treatment of periodontitis and its preparation method, belonging to the field of polymer material preparation technology. The preparation method includes the following steps: reacting MXene dispersion with epigallocatechin gallate and MgSO4; then sequentially performing ultrasonication, centrifugation, washing, and lyophilization to obtain multifunctional nanosheets MP-Mg; adding the multifunctional nanosheets MP-Mg to an aqueous solution of oxidized gellan gum for mixing to obtain solution A; mixing equal volumes of quaternary ammonium chitosan aqueous solution and carboxymethyl chitosan aqueous solution for reaction to obtain solution B; and mixing equal volumes of solution A and solution B for further reaction. The hydrogel prepared by this invention possesses injectability, photothermal responsiveness, biofilm penetration ability, synergistic antibacterial properties, and long-lasting anti-inflammatory effects, providing an innovative and practical photothermal-assisted treatment platform for the clinical treatment of periodontitis.

This invention belongs to the field of oral care technology. The invention discloses a herbal toothpaste for improving gingival bleeding and its preparation method, comprising the following components by weight: abrasive: 15-25 parts hydrated silica, 5-15 parts hydroxyapatite; humectant: 20-35 parts sorbitol, 10-20 parts glycerin; sweetener: 0.5-2 parts xylitol; thickener: 0.3-1 parts carrageenan, 0.2-0.8 parts xanthan gum; foaming agent: 1.5-3 parts sodium lauryl sulfate; preservative. The formula contains: potassium sorbate 0.1-0.5 parts; cooling agent: menthol 0.1-0.5 parts; essential oil: tea tree oil 0.05-0.2 parts; active ingredients of traditional Chinese medicine: honeysuckle extract 1-5 parts, licorice extract 0.5-3 parts, clove oil 0.2-1 parts, borax 0.1-0.5 parts; the balance is deionized water. It effectively inhibits pathogenic bacteria of gingivitis and periodontitis, solves the problem that ordinary toothpaste is not effective in relieving gingival bleeding, and significantly reduces gingival redness, swelling, bleeding and pain.