231 results about "Periodontitis" patented technology

The invention relates to the field of biomedical materials, in particular to composite hydrogel as well as a preparation method and application thereof. The composite hydrogel prepared by the invention realizes step-by-step release and time sequence regulation of a polypeptide drug through the combined action of Gel-PBA and GelMA: the anti-inflammatory peptide (Ac2-26) is quickly released under the conditions of high ROS and low pH, so that inflammation and pyroptosis are reduced; osteogenic peptide (OGP) is continuously and slowly released, and osteogenic differentiation is promoted. The step-by-step release mechanism of the anti-inflammatory peptide and the osteogenic peptide can realize accurate drug release, and is helpful for synergistically regulating inflammation and promoting bone regeneration. The composite hydrogel is used as a biological medicine material, can realize timely anti-inflammatory effect and long-term osteogenesis in a complex pathological environment such as diabetic periodontitis, and has a good application prospect.

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention relates to the technical field of biological medicines, in particular to rhizoma drynariae extracellular vesicles for treating periodontitis by targeting macrophage ETS2 genes as well as a preparation method and application of the rhizoma drynariae extracellular vesicles. The extracellular vesicles are creatively extracted from the traditional Chinese medicine rhizoma drynariae by combining a differential ultracentrifugation method with a sucrose density gradient centrifugation method, the functions of the extracellular vesicles are studied, and it is found that the extracellular vesicles can effectively slow down alveolar bone resorption in a periodontitis state and reduce periodontal soft tissue inflammation and have a good treatment effect on periodontitis. It is found for the first time that the rhizoma drynariae extracellular vesicles can reduce the inflammatory ability of macrophages in an inflammatory state and can reduce expression of proinflammatory factors TNF-alpha and IL-6. The invention has important scientific research value and clinical significance for further development and application of various traditional Chinese medicine plant extracellular vesicles including rhizoma drynariae extracellular vesicles.

The invention provides application of polypeptide in preparation of a product for treating and / or preventing gingivitis and / or periodontitis. The polypeptide with the amino acid sequence shown as SEQ ID NO: 1 is adopted for treating a gingival epithelial cell inflammation model, it is found that the polypeptide can effectively reduce the expression level of inflammatory factors IL-8, IL-1beta and TNF-alpha, and it is indicated that the polypeptide can effectively treat and / or prevent gingivitis and / or periodontitis and is suitable for preparing products for treating and / or preventing gingivitis and / or periodontitis.

The invention provides a pharmaceutical composition as well as a preparation method and application thereof. The pharmaceutical composition comprises the following raw materials in parts by mass: 2-6 parts of radix paeoniae alba, 1-4 parts of ginseng, 1-4 parts of mint and 0.3-3 parts of liquorice. The pharmaceutical composition provided by the invention adopts the radix paeoniae alba, the ginseng, the mint and the liquorice, the mint and the liquorice are medicinal and edible traditional Chinese medicines, and the radix paeoniae alba and the ginseng can be widely applied in a health food raw material list. The pharmaceutical composition is a pure traditional Chinese medicine preparation, has significant antibacterial and anti-inflammatory effects, can effectively inhibit gingival bleeding, reduce dental plaque, reduce gingival sulcus bleeding index, gingival index and dental plaque index, and significantly reduce probe depth, and has a good curative effect. The composition has a remarkable treatment effect on gingivitis and periodontitis and is free of toxic and side effects.

The invention provides a Falcarindiol derivative, preparation thereof and application of the Falcarindiol derivative in preparation of medicines for preventing and / or treating bone diseases. The structural general formula of the Falcarindiol derivative is as shown in formula I in the specification. Experimental results show that the Falcarindiol derivative can significantly inhibit osteoclast differentiation, and is expected to be used for preparing novel drugs for preventing and / or treating osteoporosis, osteoporosis fracture, osteolysis, periprosthetic osteolysis, tumor bone metastasis, inflammatory bone loss, periodontitis inflammatory bone resorption and other bone diseases. # imgabs0 #

The invention discloses a dual-network injectable hydrogel as well as a preparation method and application thereof. The hydrogel is methacrylated gelatin / oxidized hyaluronic acid loaded with metal polyphenol nano-particles, and the metal polyphenol nano-particles are copper-gallic acid nano-particles which contain quaternized chitosan coatings and are loaded with antibacterial peptide HHC36. After the hydrogel is injected into a periodontal pocket, the hydrogel can adapt to different defect shapes, and the CuGA-coated HHC36-coated QCS nanoparticles are released by responding to a periodontitis microenvironment, so that the effects of resisting periodontal pathogenic bacteria, removing local excessive ROS (reactive oxygen species), effectively promoting fibroblast proliferation, collagen deposition, extracellular matrix accumulation and angiogenesis and further promoting periodontal bone regeneration are achieved. The preparation process is simple, the injectable hydrogel is low in price and easy to obtain, the injectable hydrogel can be prepared through simple steps, and a new thought is provided for treatment of periodontitis.

The invention relates to the field of intelligent detection, in particular to a periodontal bone loss positioning and grading system based on a deep learning CT image, and the system comprises the steps: obtaining image data of a periodontal panoramic film and an apical film, carrying out the classified storage, and marking key anatomical points; inputting the preprocessed image data into a deep learning model for training and verification to obtain a periodontal bone loss positioning detection model; and based on the key anatomical points positioned by the periodontal bone loss positioning detection model, calculating a typing evaluation ratio, and based on the typing evaluation ratio, carrying out quantitative typing and site deviation judgment on the periodontal bone loss. According to the method, the key anatomical points can be automatically identified and analyzed from the high-resolution CT slice image, and the diagnosis precision and efficiency are remarkably improved. According to the method, the severity of periodontitis can be quantitatively evaluated, the disease progress can be tracked in real time, and reliable data support is provided for formulating a personalized treatment scheme.

The invention discloses a periodontitis dynamic prognosis prediction model construction method and system based on survival analysis, and the method comprises the steps: collecting and preprocessing periodontitis patient data, and constructing a structured multi-modal clinical data set; the method comprises the following steps: randomly dividing a multi-modal clinical data set into a training set and a test set according to patient IDs, only on the training set, carrying out single-factor Cox proportional risk regression analysis on all patient level data and tooth level data together, and screening indexes significantly related to periodontitis progress risks; taking periodontitis progress time as a dependent variable, and using the training set and the screened indexes to construct a time-dependent Cox periodontitis dynamic prognosis prediction model; and introducing an SHAP algorithm to analyze a prediction result of the time-dependent Cox periodontitis dynamic prognosis prediction model. The method can be used for realizing dynamic, accurate and explainable prediction of the periodontitis progress risk.

The invention discloses a composite bone graft material based on bletilla striata polysaccharide and autologous tooth bone meal as well as a preparation method and application of the composite bone graft material. The preparation method comprises the following steps: preparing bletilla striata polysaccharide, namely BSP, from bletilla striata; the method comprises the following steps: pretreating extracted teeth, and crushing to obtain autologous tooth bone powder, namely AutoBT; dissolving the BSP in water, and uniformly stirring to obtain a BSP solution; the AutoBT is poured into the BSP solution, and after standing and stirring, an AutoBT solution loaded with BSP is obtained; and carrying out vacuum drying on the AutoBT solution loaded with the BSP, and carrying out ultraviolet sterilization to obtain the composite bone graft material. The material can be applied to repairing of oral cavity bone defects, bletilla striata polysaccharide has the effects of resisting inflammation, inhibiting bacteria, promoting osteogenesis and inhibiting osteoclast, the bone steady state unbalance state in the periodontitis environment is effectively reversed, meanwhile, autologous tooth bone powder accelerates bone tissue regeneration and integration by means of the natural bionic structure and high porosity of the autologous tooth bone powder, and the bone tissue regeneration effect is improved. The risks of postoperative infection and immunological rejection are reduced.

The invention provides a nano-enzyme with sterilization, tooth desensitization and remineralization functions as well as a preparation method and application thereof, and relates to the technical field of nano-enzymes. Berberine, hemin and calcium fluoride are used as raw materials and are self-assembled into the multifunctional BHCF nano-enzyme with sterilization, tooth desensitization and remineralization functions through multi-dimensional interaction of ionic bonds, Ca < 2 + > coordination bonds, pi-pi accumulation and hydrogen bonds. The BHCF nano-enzyme has a clear peroxidase-like and superoxide dismutase-like double-enzyme catalytic capability and a photodynamic effect, the antibacterial activity of the BHCF nano-enzyme is obviously activated under an illumination condition, and the sterilization rate can reach 99.995%; meanwhile, the BHCF nano-enzyme has a good immediate and lasting sealing effect, and has excellent acid resistance, wear resistance and remineralization capacity. The BHCF nano-enzyme provided by the invention has huge application potential in preparation of drugs for treating periodontitis.

The application discloses a kind of solid teeth pain-relieving and inflammation-clearing traditional Chinese medicine composition, it is related to traditional Chinese medicine product technical field.The composition is composed of gypsum, raw rehmannia, coptis, talc, ocher, radix cyathulae and salvia miltiorrhiza seven raw medicinal materials, wherein gypsum, raw rehmannia are monarch drug, clear and purge stomach fire, cool blood and nourish yin;Coptis, talc are ministerial drug, clear heat and dry dampness, lead heat down;Ocher, radix cyathulae are auxiliary drug, heavy town counteract, lead fire down;Salvia miltiorrhiza is servant drug, promote blood circulation and remove blood stasis, promote tissue repair.Modern pharmacological research shows that each drug of the present party has the effects of anti-inflammatory, analgesic, antibacterial, improving microcirculation and protecting periodontal tissue etc.Clinical observation shows that the pain of most patients caused by stomach fire attacking upward, gum redness and swelling, burning pain, bleeding is significantly reduced after taking 1-2 doses, redness and swelling gradually subside.Compared with existing Chinese patent medicines, the present application is simple in prescription, low in cost, has the dual effects of rapid pain relief and long-term tooth fixation, and is especially suitable for patients with recurrent toothache and early periodontitis.

The invention belongs to the technical field of biomedicine, and particularly provides a periodontitis related marker which comprises glycochenodeoxycholic acid. The concentration change of the periodontitis related marker provided by the invention is directly related to the pathological mechanism of periodontitis. As bound bile acid, the bile acid is slowly degraded in saliva. And the glycochenodeoxycholic acid in the saliva is synthesized from gingival fibroblasts, so that the influence of systemic inflammatory diseases is greatly eliminated. Glycine chenodeoxycholic acid in saliva is used as a specific biomarker, a non-invasive, high-sensitivity and high-specificity detection method, system and equipment are established, objective quantitative evaluation and dynamic monitoring of periodontitis activity are achieved, the hysteresis limitation of traditional diagnosis is broken through, a convenient and non-invasive accurate diagnosis tool is provided for clinic, and the clinical application prospect is wide. And the technical blank of periodontitis activity noninvasive diagnosis is filled.

The invention discloses injectable composite collagen dispersion liquid and hydrogel thereof, a preparation method and application of the injectable composite collagen dispersion liquid in preparation of drugs for treating periodontitis, the injectable composite collagen dispersion liquid comprises freeze-dried SIS collagen, itaconic anhydride and a photoinitiator, the mass ratio of the freeze-dried SIS collagen to the itaconic anhydride is 1: (1-5), a solvent is a phosphate buffer solution, the injectable composite collagen dispersion liquid is subjected to photoinitiation, and the injectable composite collagen is obtained. To form a hydrogel. The injectable composite collagen dispersion liquid has certain flowability, directly acts on a periodontal lesion of a patient through an injector, and forms hydrogel in situ through short-time photo-initiation, the mechanical properties of the injectable composite collagen dispersion liquid and the hydrogel can meet the mechanical requirements of periodontal tissues, and the injectable composite collagen dispersion liquid has the effect of promoting osteogenesis; therefore, the compound can be applied to preparation of drugs for treating periodontitis.

The invention discloses a histone-derived peptide nano-particle for targeted degradation of cytoplasm cGAS and a preparation method and application thereof, and is characterized in that a polypeptide compound is dissolved in a phosphate buffer, ultrasonic treatment and room temperature standing self-assembly are performed to form nano-particles, and centrifugal purification is performed to obtain the histone-derived peptide nano-particle A4-CMA NPs for targeted degradation of cytoplasm cGAS. The nano-particles (A4 at CMA NPs) can be combined with cytoplasm cGAS in a targeted manner and mediate the cytoplasm cGAS to degrade, so that the activation of a cGAS-STING pathway is blocked, periodontal tissue inflammation and alveolar bone resorption are effectively relieved, and a new strategy is provided for periodontitis treatment.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

The invention relates to a dental and / or oral care product comprising between 0.0039% and 0.0078% by weight of nisin establishing and / or maintaining a pH of at least 4.5 in situ. Although said rather low nisin concentration does not provide an anti-bacterial effect, it is surprisingly and advantageously capable of maintaining stable pH values of at least 4.5, thereby preventing destruction of a subject's teeth enamel based on enamel demineralization effects at pH below 4.5, and said low nisin concentration advantageously further avoids dysbacteriosis, i.e. the oral microflora remains balanced, thus not leading to an increase of e.g. periodontitis associated bacteria.

The invention discloses a periodontitis marker and application thereof. Belongs to the technical field of biomedical detection. Experiments prove that the expression of the hsacirc0005737 in patient tissues, periodontal ligament stem cells in an inflammation microenvironment and periodontitis model mouse tissues is remarkably up-regulated, and the expression level of the hsacirc0005737 is positively correlated with the severity and activity of periodontitis. Therefore, detection of the expression level can be used for diagnosis, activity evaluation, curative effect monitoring and prognosis of periodontitis. In addition, the osteogenic differentiation capacity and inflammatory response of the periodontal ligament stem cells can be influenced by regulating the expression of the hsacirc0005737, so that the hsacirc0005737 can be used as a potential target for treating periodontitis. The invention further provides a primer sequence, a detection reagent combination and a kit for detecting the hsacirc0005737, and a new solution is provided for noninvasive, early-stage and high-specificity diagnosis and targeted therapy of periodontitis.

The present invention relates to compositions for oral hygiene comprising Crocus sativus flower extracts and their uses for protecting the oral cavity. The invention also relates to therapeutic compositions for use in the prevention and treatment of diseases of the oral cavity, in particular periodontitis and gingivitis.

Disclosed is a selenium-containing polyamino acid having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein A, B, D, E, m, n, and x are as defined in the description. Also disclosed is a pharmaceutical composition containing the selenium-containing polyamino acid or a pharmaceutically acceptable salt thereof. Also disclosed is a use of the selenium-containing polyamino acid or the pharmaceutically acceptable salt thereof, or the pharmaceutical composition containing the selenium-containing polyamino acid or the pharmaceutically acceptable salt thereof in the preparation of a drug for treating diseases selected from osteoarthritis, rheumatoid arthritis, and periodontitis. E[-(B)m-(A)n-D]x Formula (I)

This invention discloses a histone-derived peptide nanoparticle targeting the degradation of cytoplasmic cGAS, its preparation method, and its applications. The invention is characterized by: dissolving a peptide complex in phosphate buffer, sonicating, allowing it to self-assemble at room temperature to form nanoparticles, and purifying by centrifugation to obtain histone-derived peptide nanoparticles A4@CMA NPs targeting the degradation of cytoplasmic cGAS. These nanoparticles (A4@CMA NPs) can target and bind to cytoplasmic cGAS, mediating its degradation, blocking the activation of the cGAS-STING pathway, effectively reducing periodontal inflammation and alveolar bone resorption, and providing a new strategy for the treatment of periodontitis.

The invention belongs to the technical field of medicines, and discloses application of protein nano-selenium in preparation of a medicine for preventing and treating bone defects. Compared with nano-selenium particles prepared by a traditional method, the protein nano-selenium disclosed by the invention is better in antibacterial effect, higher in oxidation resistance and osteogenic induction capability and better in treatment effect on bone defect diseases such as periodontitis (such as diabetes mellitus complication), osteoporosis and the like.

The present application relates to a kind of preparation compositions containing the preparation method of loxoprofen derivative shown in general formula (I).The composition is a kind of analgesic antipyretic for preventing and treating rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, joint deformity, gout, lumbago, neck shoulder wrist syndrome and periodontitis, cold, acute respiratory inflammation, such as postoperative inflammation of the diseases of the drug composition, its composition is characterized in that the mass percentage of loxoprofen derivative is 0.5%-5.0%w / w;Including physiologically acceptable crystal inhibitor;And at least one pH regulator.The pharmaceutical composition provided by the present application, compared with the preparation of loxoprofen derivative external preparation of the current existing technical means or the method reported in the public literature, solves the problem of active ingredient crystallization of such preparation, and achieves good effect.

The application discloses application of a circFOXO3 gene expression inhibitor in preparation of a medicine for preventing and / or treating periodontitis, and belongs to the technical field of medicines.The siRNA of the circFOXO3 is adopted to down-regulate the expression of the circFOXO3 gene, so that the expression amount of ITGB6 is up-regulated, the activation of TGF-beta 1 is promoted, and then the occurrence and development of periodontitis are inhibited.The siRNA of the cholesterol-modified circFOXO3 can increase the stability and in-vivo metabolic time of the siRNA.

This invention discloses a near-infrared light-exciteable composite nanosheet, its preparation method, and its applications, belonging to the field of biomedical technology. The method includes the following steps: mixing epigallocatechin gallate with a Ti3C2 nanosheet dispersion, ultrasonically reacting, adding silver salt, and continuing stirring in the dark; after the reaction is complete, washing and separating to obtain MXene-EGCG@Ag composite nanosheets. The composite nanosheets provided by this invention possess near-infrared light-exciteable properties and can be used to prepare medically acceptable dosage forms such as hydrogels for the treatment of periodontitis. The preparation method provided by this invention is simple, the raw materials are readily available, and it exhibits significant antibacterial and anti-inflammatory effects, enabling further widespread application.

Disclosed in the present invention are an antibacterial electric toothbrush based on a pulsed ultrasonic piezoelectric response principle, and an antibacterial method. The electric toothbrush in the present invention comprises a toothbrush head and a driving mechanism for driving the toothbrush head to vibrate, wherein the driving mechanism is configured to generate low-intensity pulsed ultrasonic waves, and the toothbrush head is provided with piezoelectric bristles and enhances the electric responsiveness of the piezoelectric bristles by means of ultrasonic vibration, such that a good antibacterial effect is achieved. The provided electric toothbrush can not only effectively inhibit the growth of bacteria on a standing toothbrush head, but also has improved antibacterial activity during a tooth-brushing operation process, such that dental plaque can be effectively inhibited, and oral diseases, such as periodontitis, can be effectively prevented.

The invention discloses double-response hydrogel as well as a preparation method and application thereof. The double-response hydrogel comprises a three-dimensional porous network hydrogel matrix, and tea polyphenol and nano silicon nitride which are loaded in the hydrogel matrix, the three-dimensional porous network hydrogel matrix is prepared from o-nitrobenzene grafted hyaluronic acid and carboxyl phenylboronic acid modified methyl chitosan. According to the hydrogel disclosed by the invention, in a low-pH / high-ROS microenvironment of a diabetic periodontitis focus, boric acid ester bonds are broken, tea polyphenol is released, and the tea polyphenol plays an anti-inflammatory role by efficiently removing active oxygen and inhibiting inflammatory factors; meanwhile, the Schiff base bond is dissociated to release the nano silicon nitride, and the nano silicon nitride significantly promotes angiogenesis and osteogenic differentiation and accelerates bone defect repair by activating a redox signal, inducing cell autophagy, regulating metabolic reprogramming and other pathways.

The present invention relates to a composition for preventing or treating periodontitis, which contains cannabidiol and taurine. The composition of the present invention can effectively prevent or treat periodontitis by inhibiting inflammatory factors and directly suppressing alveolar bone loss. Furthermore, the composition is safe for the human body and has few side effects, making it suitable for a variety of uses, such as as an ingredient in pharmaceuticals, quasi-drugs, or health functional foods.

The invention belongs to the technical field of biological medicines, and particularly discloses application of inhibiting histone demethylase KDM4D in prevention and treatment of periodontitis. By constructing a mouse periodontitis and periodontitis animal model accompanied by systemic diseases, the influence of KDM4D intervention on periodontitis and periodontitis accompanied by systemic diseases is studied, and experimental results show that inhibition of KDM4D can down-regulate the expression level of osteoclast related genes, inhibit osteoclast differentiation, relieve alveolar bone resorption and bone loss, inhibit osteoclast differentiation and inhibit osteoclast differentiation. The traditional Chinese medicine composition has an obvious curative effect on periodontitis and periodontitis accompanied by systemic diseases, and a new prevention and treatment strategy is provided for periodontitis and periodontitis accompanied by systemic diseases.

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the specification; and also relates to a method for preparing the compound and its use as a photosensitizer in photodynamic therapy. The monosubstituted protoporphyrin derivatives involved in the present invention all have high permeability, high activity, and good biosafety. The preparation method is simple, low-cost, and can obtain the target product in good yield. It is particularly suitable for industrial production and can be used as a highly effective photosensitizer in photodynamic therapy to treat oral diseases such as periodontitis, gingivitis, dental plaque, and caries caused by Gram-negative anaerobic cocci and other bacteria such as Porphyromonas gingivalis.