890 results about "Periodontitis" patented technology

The present invention includes compositions and methods for the treatment and prevention of oral mucosal disorders and for promotion of bone health. In particular, the present invention describes new therapeutic and preventative uses for 3,3′-diindolylmethane (DIM), or a DIM-related indole, alone or in combination with anti-inflammatory agents and / or antibacterial agents, to treat oral mucosal disorders and promote bone health. The compositions of the invention are used to prevent and reverse oral mucosal disorders and bone loss (osteopenia and osteoporosis) associated with aging and chronic inflammation. Oral mucosal disorders include Periodontitis, gingivitis and related oral mucosal inflammation. Formulations of the compositions of the invention include capsules, tablets, toothpastes, oral gels, mouthwashes, mouth rinses, lozenges, chewing gum, dental floss, and dental topical formulations, and fortified foods.

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, perdiodontitis, and oral malodor while also promoting general oral hygiene.

The present invention is directed to dental compositions, including dentifrices, containing ascorbic acid for removing and inhibiting dental biofilms which form plaque and tartar, and also for treating and preventing gingivitis and periodontitis. The ascorbic acid composition can contain may additional ingredients, including an enamel-strengthening component, and be used in many different forms, including breath spray, chewing gum, dental floss, dental powder, gargle, lozenge, mouth spray, mouth wash, tooth gel, tooth liquid, tooth paste and tooth strips. Also described in a method of using a dental composition containing ascorbic acid in order to treat plaque and tartar as well as gum disorders.

This invention is directed to methods for treating conditions which present with low bone mass in a patient in need thereof using continuous combination therapy with a synergistically effective combination of an EP4 receptor selective agonist or a pharmaceutically acceptable salt thereof, such as 5-(3-{2S-[3R-hydroxy-4-(3-trifluoromethyl-phenyl)-butyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid or a pharmaceutically acceptable salt thereof; and an estrogen or a pharmaceutically effective salt thereof, The present methods are useful for treating conditions that present with low bone mass including osteoporosis, osteotomy, osteoporotic fracture, childhood idiopathic bone loss, periodontitis and low bone mass and for enhancing bone healing following facial reconstruction, maxillary reconstruction or mandibular reconstruction, inducing vertebral synostosis, enhancing long bone extension, enhancing the healing rate of a bone graft or a long bone fracture or enhancing prosthetic ingrowth in a patient in need thereof.

A laser system and method are described that will improve dental treatments in small animals, particularly in situations where periodontal disease has progressed to the advanced stages of periodontitis and when dental pulp is exposed by fracture or disease. A laser system is employed to achieve enhanced precision by selectively ablating affected tissue without damaging the collateral tissue. The laser system is also capable of sealing the tubules and eradicating bacteria within the periodontium to significantly reduce the risk of infection. Additional pre-treatment methods may be employed to further enhance the laser therapy.

Abstract of Disclosure The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula wherein A is an amino acid having at least one functional group in the side chain;B is a chemical compound covalently bound to a functional group of the side chain of A, chosen from the group consisting of (a) oligopeptides having a chain length of up to 20 amino acids, (b) homopolymers of glycine consisting of up to 6 glycine monomers, and (c) polyethylene glycols having molar masses of up to 20 000 g / mol; and C is a group amide-bonded to A chosen from the group consisting of thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, dehydroproline or piperidine. The invention further relates to the use of said compounds for targeted intervention in local immunological processes (chemotaxis, inflammatory processes, autoimmune diseases), as well as effective and targeted treatment of pathophysiological and physiological processes related thereto (psoriasis, periodontitis, arthritis, allergies, inflammation), inter alia.

This invention relates to a cysteine protease inhibitor comprising casein which is a protein derived from milk, a partial peptide of casein, and / or hydrolysate of casein as an active ingredient. The cysteine protease inhibitor of the present invention can be used as preventive or therapeutic drug for osteoporosis, malignant hypercalcemia, breast cancer, prostate cancer, periodontitis or bacterial and viral infectious diseases, and food, drink, feed and the like.

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Disclosed is a composition and method for the treatment and prevention of bad breath, halitosis, gingivitis, and / or periodontitis that contains one or more varieties of probiotic bacteria from the groups Lactobacillus, Bacillus, Escherichia, Enterococcus, Streptococcus, and Bifidobacterium, and / or a species of the yeast genus Saccharomyces. The composition may be in a variety of forms, such as a toothpaste, mouthwash, oral spray, oral cream or gel, chewing gum, candy, lozenges, dissolvable pill or strip, or powder that may be sprinkled directly into the oral cavity.

Compositions and methods for treating, reducing, or preventing a disease or symptom such as gingivitis, periodontitis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, or pain. The method includes identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

The invention discloses an oral care composition with fire clearing and pain eliminating functions. The oral care composition with fire clearing and pain eliminating functions is prepared from the following raw materials in percentage by mass: 0.01-1% of bezoar, 0.1-5% of scutellaria baicalensis extract, 0.1-5% of honeysuckle extract, 0.1-5% of rhizoma cimicifugae extract, 0.01-0.5% of borneol, 0.1-5% of sodium gualenate, 0.1-5% of nicotinamide and the balance of base material. The oral care composition with fire clearing and pain eliminating functions, disclosed by the invention, is targeted at people susceptible to oral inflammation and toothache and people suffering from gingivitis and periodontitis; and through a compounding technology, the oral care composition has the functions of cleaning the oral cavity and refreshing breath and also realizes the effects of clearing fire and eliminating pain, relieving toothache and gum bleeding and the like.

A composition and method of stabilized chlorine dioxide at a concentration range of about 0.005% to about 0.800% (w / v) at a pH in the range of 6.0 to 7.4 for the prevention of oral diseases caused by dental biofilm and plaque accumulation, such as gingivitis and periodontitis, through bactericidal properties is disclosed. The bactericidal properties of stabilized chlorine dioxide are further expanded to include reduction (kill) of anaerobic / aerobic / facultative gram-negative and gram-positive oral bacteria occurring in plaque or polymicrobial biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, aerosol spray, or other suitable delivery system.

New oral rinse solutions and mouthwashes are provided. The oral rinse solutions comprise essential oil and alcohol, supplemented with hydrogen peroxide, and natural extracts. The essential oil and / or alcohol can be provided as part of a base composition. The most preferred base compositions are antiseptic mouthwashes containing the essential oil and / or alcohol. Alternatively, the ingredients can be individually added to the inventive composition. The oral rinse solutions provide antimicrobial activity while soothing oral inflammations and irritations, thus being useful for treating, alleviating, and promoting healing of a wide variety of oral ailments such as periodontal disease (gingivitis and periodontitis), plaque, oral inflammation, toothaches, oral ulcerations, dry socket, dentin hypersensitivity, and halitosis, as well as address aesthetic issues such as bad breath and tooth discoloration.

The present invention relates to an oral composition containing a zinc compound containing free available zinc ion and at least one stabilized or stable Eh raising compound distributed in an oral vehicle. The present invention further relates to a method of inhibiting the formation of sulfur containing anions and preventing a reduction in the Eh of the oral cavity. A method of reducing oral malodor and gingivitis and periodontitis is also provided by this invention.

The invention relates to a medicine sustained release nanofiber membrane for treating periodontitis and a preparation method for the medicine sustained release nanofiber membrane. The nanofiber membrane comprises biodegradable polymer, cellulose nanocrystals and an active medicine, wherein the mass ratio of the biodegradable polymer to the cellulose nanocrystals is (4-99):1; and the actual loading capacity of the active medicine of the nanofiber membrane is 10 to 500mu g / mg. The preparation method for the medicine sustained release nanofiber membrane comprises the following steps of: (1) adding the cellulose nanocrystals which are dispersed in an organic solvent A into an organic solution B of the biodegradable polymer with stirring to obtain mixed liquid; (2) adding the active medicine into the mixed liquid to obtain an electrostatic spinning stock solution; and (3) performing electrostatic spinning on the electrostatic spinning stock solution, drying a product, and thus obtaining the nanofiber membrane. The preparation process is simple, quick, cheap and efficient, and is suitable for industrialized batch production; and the obtained nanofiber membrane has high biocompatibility, high medicine loading capacity, appropriate hydrophillic performance and a broad application prospect, and the sustained release of the active medicine is slow.

The invention relates to toothpaste containing dencichine, which is characterized in that the toothpaste is prepared by adding arasaponin and dencichine into a toothpaste matrix, wherein the weight percent of the arasaponin is 0.2-1.2% and the weight percent of the dencichine is 0.01-1.0%. The toothpaste according to the invention can kill pyococcus, candida albicans, staphylococcus aureus, anaerobic bacteria and other pathogens which can cause gingivitis, periodontitis, canker sores, halitosis, ngival hamorrhage, caries and other symptoms in the oral cavity and eliminate the peculiar smell in the oral cavity. The effective rate for the gingivitis and the ngival hamorrhage achieves 94.6%; and the effective rate for the canker sores achieves 89%, and the efficacy is significant. The toothpaste has no toxicity or side effects, is safe to use and can prevent drug resistance. The toothpaste has significant efficacy for the gingivitis, the ngival hamorrhage, the canker sores and the like. The hemostatic effect of the toothpaste is well promoted. Sanchi extract and the dencichine are simultaneously used in the toothpaste, thereby enabling the effects of relieving pain and preventing thegingivitis, the ngival hamorrhage and the pain of the toothpaste to be more significant.

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

The invention relates to applications of a mesenchymal stem cell and a genetically modified mesenchymal stem cell, especially relates to applications of a mesenchymal stem cell and a genetically modified mesenchymal stem cell in preparation of products for treating periodontal disease, repairing periodontal bone tissue or soft tissue defect and / or promoting regeneration of periodontal tissue. The invention further relates to a composition containing the mesenchymal stem cell and / or the genetically modified mesenchymal stem cell, and a cell patch. According to the invention, prosthodontic treatment effect of MSC (Mesenchymal Stem Cells) from different sources on the periodontal bone defect and periodontitis soft tissue is proved successfully, and a strong evidence for expanding seed cell source is provided; meanwhile, the application also proves that the prosthodontic treatment effect of MSC modified by an HGF (Hepatocyte Growth Factor) gene on periodontal bone defect and periodontitis soft tissue is superior to that of simple MSC, and shows that HGF and MSC can play a role in cooperation in prosthodontic treatment of periodontal bone tissue or soft tissue defect and / or promoting regeneration.

The invention pertains to the field of daily chemical industry and discloses a Chinese herbal toothpaste made from bletilla striata. The Chinese herbal toothpaste made from bletilla striata contains a toothpaste matrix which comprises paeonol and bletilla striata or the bletilla striata polysaccharide. The toothpaste has the functions of antibiosis, anti-inflammation, promotion of wound healing, hemostasis and the like, therefore, the toothpaste can be applied to preventing and treating oral diseases and dental diseases such as ulcerative stomatitis, throat irritation, periodontitis, gingivitis, dental caries, oral malodor and the like, and provides a new toothpaste for health care of oral cavity.

The present invention for the first time discloses a method and a kit of parts for treating a periodontal disease, such as periimplantitis, gingivitis, periodontitis and / or periimplant mucositis, caused by microorganisms that colonize a tooth and / or implant surface at, above and / or below the gingival margin, and which reside in a biofilm either subgingival and / or supragingival, characterized by employing a surgical process leading to substantively removing, destroying, killing and / or disrupting and / or inhibiting growth and / or regrowth of a pathogenic biofilm at a site of a microbial infection in a patient suffering from a periodontal disease. Said method comprises, and said kit of parts comprises the means for; cleaning disinfecting and / or debriding the site of microbial infection mechanically and sequentially using first at least one cleaning and / or disinfecting agent with an immediate bactericidal effect, such as a NaClO solution, and thereafter at least one cleaning and / or disinfecting agent with a sustainable bactericidal effect, such as a CHX solution.

A toothbrush is disclosed, in which wing hairs are arranged in a V-shape in left and right sides with respect to the center hairs which are the center toothbrush hairs planted in forward and backward directions in a toothbrush head, and the V-shaped wing hairs of the left and right sides are arranged in a X-shape, and auxiliary hairs are arranged between the forward and backward wing hairs in part of the X-shaped toothbrush hairs. With the above arrangements, a contact surface area of each tooth is widened, and a more effective tooth brushing can be performed in three fossas (mesial fossa (mesial pit), a central fossa (central pit) and a distal fossa (distal pit)), a buccal developmental groove, a lingual developmental groove, an accessory groove, a triangular groove and a buccal groove of a buccal aspect, which correspond to a dental caries portion, an interproximal space in which a food debris might be accumulated, and a contact area peripherals of a buccal aspect in which a food debris might be impacted, so dental caries and tooth diseases (periodontitis) can be advantageously prevented, and a pain due to a temporomandibular disorder and a facial muscle fatigue might be reduced and recovered by protruding a cushion layer from an upper side of a toothbrush.

The invention provides a pure Chinese medicinal herb gargle for curing stomatitis, and the gargle is composed of following Chinese medicinal herbs: 20 to 40 parts of aloe leave, 10 to 25 parts of ginkgo, 10 to 25 parts of ginkgo leave, 10 to 25 parts of mint leave, 10 to 20 parts of honeysuckle, 10 to 20 parts of wind chrysanthemum, 3 to 5 parts of tuckahoe, 5 to 10 parts of fruit of glossy privet, 5 to 8 parts of liquorice and 5 to 10 parts of balloon flower root. The medical gargle prepared by the invention can resist bacterium, diminish inflammation, release pain and promote muscle; the medicine has long effect in the oral cavity, the curative effect is fine without side effect; through resisting bacterium and diminishing inflammation, repairing and acting the cells damaged in the oral cavity so as to reduce the bacterium quantity in the oral cavity, the Chinese traditional herbal medicine gargle can reach the effect of curing both symptoms and root cause at the same time, and is a ideal medicine for curing the stomatitis, ulcerative stomatitis, pharyngitis, laryngitis, oral aphthae, oral peculiar smell, periodontitis and ngivitis.

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-Ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity and reduces cytokine production at the mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and / or isolated from a single plant or multiple plants, preferably in the Scutellaria, Oroxylum, Acacia or Uncaria genus of plants and pharmaceutically and / or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including but not limited to periodontal diseases, such as gingivitis, periodontitis, pulpitis, periodontal conditions caused by the physical implantation of oral dentures, trauma, injuries, bruxism, neoplastic and other degenerative processes; material alba, pellicles, dental plagues, calculus, and stains. Use of the composition described herein also affords the benefit of maintaining optimum saliva production and pH, minimizing bacterial growth, reducing the formation of pellicles and plague, inhibiting tooth decalcification and tooth caries (decay), promoting remineralization, which yields healthy gums, whitening teeth, maintaining healthy oral hygiene and reducing oral malodour (halitosis).

A slow-dissolving troche with polyol molecules is disclosed. It may be an adherent troche, preferably adhered to teeth or gums or cheek with acacia gum, or a lollipop or child's pacifier. Consumers are instructed to use the troches at the end of each day and after each meal, at least four times per day to benefit oral health, particularly caries, gingivitis, periodontitis, ear infections, sinus infections, halitosis and risk of Streptococcus mutans infecting their blood from their mouths. The polyol molecules are preferably xylitol. The troches may be made with a bi-layer tablet press rounded on one side and flat on the other, preferably using acacia gum in the flat side layer for adhesion.

A method for determining the available treatment dosage of stabilized chlorine dioxide in the prevention and the treatment of plaque accumulation, volatile sulfur compound production, gingivitis and periodontitis, and for differentiating the treatment dosage from other chlorine-containing compounds that may not have such beneficial effects is disclosed. When in solution as stabilized chlorine dioxide, the presence of other ions such as chlorate and chloride may not only obscure results as to the concentration of stabilized ClO2, but also reduce the predicted effectiveness. The present invention uses validated analytical methods to predict the effectiveness of stabilized ClO2 by more precisely measuring its concentration in solution. Such measurement renders precision at a level required of food-grade and pharmacy-grade chemotherapeutic agents in the oral cavity. Preferred concentrations are within the range of about 0.005 to about 2% (w / v) stabilized chlorine dioxide. The solution may be in the form of wash, rinse, soak, paste, gel, aerosol spray, or other suitable delivery system.

A cultured periodontal ligament cell sheet is produced by a process comprising culturing cells on a cell culture support composed of a base material whose surface is coated with a temperature-responsive polymer having an upper limit or lower limit critical dissolution temperature in water of 0 to 80° C. under specified conditions, (1) regulating the temperature of a culture fluid to the upper limit critical dissolution temperature or higher or to the lower limit critical temperature or lower, (2) allowing a cultured periodontal ligament cell sheet resulting from the culturing to adhere to a carrier and (3) detaching the sheet intact together with the carrier. This cultured periodontal ligament cell sheet has a syndesmotic microstructure, exhibits extremely high bioadherence to the dental root surface and realizes high density transplantation of target cells and positive reconstruction of periodontal tissues. Moreover, through lamination of cell sheets to be transplanted and donation of a three-dimensional polarity, highly efficient reconstruction of an adhesion apparatus can be accomplished and clinical application thereof to moderate periodontitis, severe peridontitis, gingival recession and the like is highly promising.

The invention discloses morning and night heat-removing combination toothpaste and night heat-removing toothpaste. The morning and night heat-removing combination toothpaste comprises an abradant, a humectant, a thickening agent, traditional Chinese medicinal components which are bacteriostatic, zinc citrate and a vinyl methyl ether / maleic anhydride copolymer. The invention provides the combination of morning toothpaste and night toothpaste which nurse the oral cavity in the morning and at night. The morning toothpaste has the effect of nursing teeth, the night toothpaste has the effect of enhancing for a long time, and the morning effect and the night effect are overlapped to ensure the health of the oral cavity. Dental plaques and dental calculus can be effectively prevented by using different toothpaste in the morning and at night, so the causes of parodontitis are eliminated radically, and the problems of gum bleeding, red and swollen gum and oral malodor can be effectively solved.