618 results about "Fibrous membrane" patented technology

The invention relates to compound millimicron fibrous membrane material of cellulose and cellulose matrix which can perform the biological degradation and the biological absorption and a preparation method thereof and an industry and medical purpose, and belongs to the biological macro-molecule non woven fabric material field which can perform the biological degradation and the biological absorption. Electrostatic spinning equipment is used to obtain the fibrous membrane material which can perform the biological degradation and the biological absorption, the weight of the cellulose is taken as basic reference, the component of the material comprises cellulose more than 0 and less than or equal to 100 weight parts, other biomacromolecule more than and equal to 0 and less than 100 weight parts, 0 to 10 weight parts of curative drug or 0 to 50 weight parts of inorganic catalyzer and / or 0 to 50 weight parts of inorganic strengthening agent. The material of the invention has good biological compatibility, biological degradation property and degradation absorptivity, and can be used for haemostasia material, wound cladding material, organization engineering supporting rack material, the transportation and release of medicine, artificial skin and blood vessel, and postoperation anti blocking material, beauty material and catalyzer carrier, filtering membrane and radiation protection material and so on.

The invention relates to a gelatin nanometer fiber film which can biologically degrade and absorb, and relative preparation, wherein it via the control on static spin realizes the static spin on gelatin water solution and gelatin / macromolecule mixture water, to obtain the nanometer fiber, which comprises: 0 A61L 27 / 14 A61K 45 / 00 D01D 5 / 00 D01F 1 / 00 A61L 27 / 60 A61L 33 / 06 A61L 24 / 04 A61L 15 / 22 A61F 2 / 02 2 14 3 2005 / 11 / 9 1961974 2007 / 5 / 16 000000000 Institute of Chemistry Chinese Academy of Science Beijing 100080 Han Zhichao He Aihua Li Junxing libai 31002 Shanghai Patent Agency of the Chinese Academy of Sciences No.319 Yueyang Road, Shanghai 200031

The invention provides a preparation method of fibrous membrane with a super hydrophobic multi-stage nanometer structure, which is characterized by comprising the following specific steps: 1, at room temperature, adding hydrophobic polymer and hydrophobic inorganic nanoparticles into a sealed container filled with solvent, putting the sealed container on a magnetic stirrer to stir at the revolving speed of 10-200 rpm, and obtaining solution with even property; 2, at room temperature, inputting solution obtained in step 1 onto a spinning nozzle at constant flow velocity; connecting the spinning nozzle to a high voltage static generator to carry out electrostatic spinning; and receiving spun fiber by a receiver to obtain the fibrous membrane with super hydrophobic multi-stage nanometer structure. The invention can drastically improve the hydrophobic performance of the fibrous membrane.

The invention provides a preparation method of high elasticity super hydrophobic high temperature silicon dioxide fibrous membrane. The invention is characterized in that the method includes the following steps: template polymer is stirred in solvent at 60 DEG C to obtain template solution with mass concentration of 5-30%; organic silicon or nano silicon dioxide are mixed with water and inorganic acid at normal temperature to obtain silicon source solution; the template solution and the silicon source solution are mixed to be uniform at normal temperature to obtain electro spun solution; the electro spun solution is subject to electrostatic spinning at normal temperature to obtain composite fibrous membrane; the compound fibrous membrane is placed into a muffle furnace to be forged, so as to obtain a nano silicon dioxide fibrous membrane; the nano silicon dioxide fibrous membrane is placed into organic silicon hydrocarbon compound solution to be soaked for 6-30h and then is dried in vacuum, thus obtaining the high elasticity super hydrophobic high temperature nano silicon dioxide fibrous membrane. The material is antifouling and self-cleaning under high temperature high pressure severe environment.

The invention discloses a bionic three-dimensional tissue engineering scaffold, which is formed by high molecular fibrous membrane-loaded active growth factors, or active growth factors loaded on a composite scaffold formed by a high molecular fibrous membrane and a macropore spongy layer. With the adoption of the bionic three-dimensional tissue engineering scaffold, the problem that the concentration of active molecules loaded with an emulsion electricity texture fibrous membrane is low; the emulsion electricity texture fibrous membrane is combined with a macropore spongy or a mixed electricity texture process, so that the load rate of the active factors can be greatly improved; parts of factors are retained in the fiber through an emulsion electricity texture core-shell structure, so that the effective control of releasing time is realized, and a repairing process is monitored for a long time; and the introduction of active molecules in the scaffold plays guiding and promoting functions for proliferating regenerative cells, directionally differentiating, migrating and adhering cells, and capturing stem cells to introduce regenerative functions of newly born tissues, so that a new path is provided for development of regenerative medicine industries.

A nanometer superfine chitosan fibrous membrane material and its preparation process are disclosed. It belongs to tissue repair material technology. The film material with the diameter being 10 ª–mí½50ª–m, is made by chitosan with mass percent of 10-90% and polyvinyl alcohol or polyethylene oxide superfine fiber with diameter of 50nm -500nm The preparation process is: dissolving chitosan to acetic acid solution, adding PVA pr PEO into the solution, the mass ratio of chitosan with PVA / PEO being 10 / 90í½90 / 10, injecting the prepared 4%-8% spinning solution to the electrostatic spinning device for spinning to film material, therein, voltage being 5kVí½30kV, liquid inventory being 0.1mL / hí½0.5mL / h, receiving range being 5cmí½25cm. The advantages of the invention : large volume absorbing ability, favorable cell affinity, capable of degrading in vivo and promoting defect tissue repairing when the film material is utilized as artificial skin or artificial cartilage. In addition, the preparation process is simple.

The invention discloses a method for preparing a long fiber reinforced hollow fibrous membrane. The method can be implemented in two ways: (1) adopting a spinning nozzle having a long fiber channel; introducing a long fiber into the long fiber channel; guiding the long fiber into a membrane casting solution and fiber compounding area via a fiber positioning plate; co-extruding the compounded long fiber and membrane casting solution; and forming a membrane under the action of core solution and external coagulating bath or cooling bath, and (2) adopting a spinning nozzle for co-extruding the long fiber and the membrane casting solution; guiding the long fiber out of a liquid material jar; guiding the long fiber to pass by a membrane casting solution pipeline and introducing the long fiber into the spinning nozzle from a membrane casting solution inlet of the spinning nozzle; co-extruding the long fiber and membrane casting solution after positioning the long fiber through the fiber positioning plate; forming the membrane under the action of core solution and external coagulating bath; and finally winding the membrane through a guide wheel and a winding machine. The long fiber reinforced compound membrane prepared by using the method has the advantages that the mechanical strength of the hollow fibrous membrane is increased by 3-5 times according to the quantity and variety of the long fiber in the hollow fibrous membrane, and the water flux, the rejection coefficient and the hydrophilicity are all obviously improved.

The present invention relates to an immersion hollow fibrous membrane separating device and the operation method thereof. The device comprises a membrane filtration system, a water producing system and a cleaning system which are connected by the tubes and a control system which is connected by a circuit, the present invention is characterized in that the membrane filtration system takes an immersion type, adopting a column external pressure hollow fibrous membrane component, a plurality of holes are arranged at the casing, the device is directly and vertically arranged in the processed water body; the water producing system comprises a pressure gauge, an automatic intake valve, a water producing pump, a flow meter and an automatic discharge valve which are sequentially connected with a water producing opening of the membrane module; the cleaning system comprises a backflushing system, a gas vacuole scrubbing system and a chemical cleaning system, the gas vacuole scrubbing system comprises a flow meter, an air inlet valve, an air adjusting valve, a filtrating pressure reducing valve, an air receiver and an air compressed valve which are sequentially connected with the backflushing air intake of the membrane module. The operation method includes a plurality of cyclic processes as follows: 1. an operating state, a backflushing state, a gas vacuole scrubbing state and a pollution discharge state; 2. the operating state, the backflushing and gas vacuole scrubbing state, an gas vacuole scrubbing state and the pollution discharge state; 3. the operating state, a chemical backflushing state, the gas vacuole scrubbing state and the pollution discharge state.

The invention provides a preparation method of a beta crystalline phase polyvinylidene fluoride hollow fibrous membrane, relating to a membrane manufacture technology of preparing the polyvinylidene fluoride hollow fibrous membrane by a thermally induced phase separation method, in particular to the method of preparing the polyvinylidene fluoride hollow fibrous membrane with the beta crystalline phase of high-flux and high strength by the thermally induced phase separation method. The invention is characterized in that on the basis of a porous membrane prepared by the thermally induced phase separation method, a continuous post-processing method combining stretching and annealing is additionally carried out so as to obtain as much as possible beta crystal form polyvinylidene fluoride intensity; the polyvinylidene fluoride hollow fiber membrane prepared by the method has even distribution of a pore diameter and high water flux; and the product of which the intensity is not processed is improved more greatly.

The invention provides an antibacterial wound dressing and a preparation method thereof. The antibacterial compound type wound dressing is characterized by comprising a chitosan-based medicine carrying compound antibacterial ultrafine fibrous membrane, a calcium alginate fiber non-woven fabric and a supporting protective layer which are sequentially arranged from top to bottom. The medicine carrying ultrafine fibrous membrane obtained by adopting an electrostatic spinning method has the advantages that the surface area of a medicament can be effectively increased, medicines can be slowly and sustainably released by virtue of high porosity and uniform pore diameter of ultrafine fibers, so that the medicines can be fully absorbed by a human body, medication is not need to be carried out frequently, the effect of the medicines can be maintained, and toxic and side effects of the medicines are reduced.

The invention discloses a fibrous membrane for tissue repair, a manufacturing method thereof, application thereof for the preparation of products for tissue repair, and a product for tissue repair which is made by the fibrous membrane for tissue repair. The fibrous membrane for tissue repair is formed by interweaving cellosilks with the diameter of 10 nanometers-100 micrometers, and is of a porous structure; the filling power is 200-2000 cm<3> / g. According to the fibrous membrane for tissue repair, the conglutination and the proliferation of cells are facilitated, the guide of the cell differentiation is facilitated, the rapid growth of fibrocytes is facilitated, the tight suture between the fibrous membrane and tissue is facilitated, the comfort of a patient is improved, and the occurrence of conditions of patch shrink, infection and conglutination with visceral organs and the like is reduced.

The invention relates a biodegradable and absorbable natural polymer-based nano-fibrous membrane prepared by a freeze-drying method, and the application thereof. The natural polymer-based nano-fibrous membrane is prepared through the following steps of: dissolving natural polymer powder into a corresponding solvent so as to prepare an extremely-dilute solution with the concentration of 0.001-0.1wt %; after the natural polymer powder is completely dissolved in the solvent, transferring the obtained natural polymer solution into a liquid nitrogen refrigerating device, so that the natural polymer solution is rapidly frozen in a liquid nitrogen environment; then, carrying out freeze-drying treatment on the obtained product in a freeze drier for 12-48 hours to obtain natural polymer-based nano fibers; and carrying out cross-linking on the obtained natural polymer-based nano fibers by a corresponding cross-linking agent to obtain a natural polymer-based nano-fibrous membrane, and then carrying out MTT (methyl thiazolyl tetrazolium) cytotoxicity test and cell vaccination experiments on the natural polymer-based nano-fibrous membrane, with the obtained results showing that the obtained fibrous membrane has no toxicity but has excellent cell adhesion and proliferation properties. The natural polymer-based nano-fibrous membrane disclosed by the invention is simple in the operation process, easy to control and low in cost; and by using the nano-fibrous membrane disclosed by the invention, ultra-fine natural polymer-based nano fibers can be prepared continuously on a large scale.

The invention discloses a preparation method of antibacterial silver / chitosan nano fibrous membranes, pertaining to the preparative technologies of nano composite fibrous membranes. The process of the method includes that a chitosan hexanoic acid solution, a silver nitrate aqoeous solution, a sodium borohydride water solution and an ethylene epoxide hexanoic acid solution are prepared and mixed to form compounded latex according to the volume ratios of the chitosan hexanoic acid solution and the silver nitrate aqoeous solution as well as an NaBH4 aqueous solution. The compounded latex and the ethylene epoxide hexanoic acid solution are mixed according to the volume ration to prepare a spinning solution, then the spinning solution is added into an injector in an electrostatic spinning device and electrostatic spinning is carried out to form the fibrous membrane. Crosslinking treatment is carried out to the fibrous membrane to obtain the antibacterial silver / chitosan nano fibrous membrane. The antibacterial silver / chitosan nano fibrous membrane of the invention has the advantages that the preparation process is simple; the prepared membrane material has broad-spectrum bactericidal property and comparatively high fatality rate to Bacillus coli, Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa for 24 hours.

The invention relates to a preparation method of a shell core fiber covered endovascular stent graft. The steps are as follows: firstly, a polymer is dissolved in adaptive dissolvent to obtain solution with a certain concentration; secondly, medicine or an artificial polymer and medicine, and a bio-active element are dissolved in the adaptive dissolvent to obtain solution or suspension liquid; thirdly, the solution of the polymer and the medicine or the solution or suspension liquid of the medicine or bio-active element are respectively filled in two injectors, the speed of a micro injection pump, the voltage of an electrostatic generator and the distance of a receiving device are adjusted, fiber is obtained through the static spinning preparation, and the fiber is received as a tube shape or film shape structure; fourthly, the endovascular stent graft is fixed on a revolution axle, through the revolution of the endovascular stent graft, the static spinning fiber are directly received as fibrous membrane covered on the endovascular stent graft. The invention can effectively prevent smooth muscle cells from hyperplasia in the stent graft or from narrowing in the stent graft caused by the other functions, and the shell core fiber for the medicine loading can slowly release the medicine to attain the purpose of curing.

The invention relates to a three-layer electrostatic spinning ordered fiber nerve conduit and preparation and application thereof. The conduit comprises an inner layer, a middle layer and an outer layer, wherein the inner layer is a micron fibrous membrane, the middle layer is a polymer degradable reticulate conduit, and the outer layer is a submicron fibrous membrane with a three-dimensional reticulate structure. The preparation comprises the following steps of: (1) dissolving a PHBV in chloroform / acetone solution to prepare mixed solution; (2) performing electrostatic spinning on the mixed solution to prepare a fibrous membrane; (3) taking the fibrous membrane from a winding bobbin, and winding into an inner pipe; (4) weaving polymer degradable fibers into the reticulate conduit, and sleeving on the inner pipe; and (5) fixing a core rod sleeved with the inner pipe and the reticulate conduit on a high-speed winding and collecting device, and performing the electrostatic spinning on the mixed solution. The conduit has double functions of the nerve conduit and a tissue engineering support, and is favorable for the attachment of cells and the growth and the expansion of nerves along a fiber parallel direction; and the preparation method has the advantages of simpleness, no environmental pollution and suitability for industrialized production.

The invention provides a preparation method of a protein-grain-supported-in-beaded-fiber tissue engineering fiber support frame, which is characterized by comprising the following specific steps: step 1, preparation of solution A: dissolving a high polymer into a solvent to obtain solution A; step 2, preparation of solution B: adding the protein grain into the solution A and uniformly agitating under magnetic force to obtain solution B; step 3, electrostatic spinning: adding the solution B into an injector, setting the spinning voltage, the spinning speed and the spinning distance, carrying out electrostatic spinning and collecting a fibrous membrane on a receiver; and step 4, standing and airing the collected fibrous membrane at a room temperature and stripping the receiver to obtain the protein-grain-supported-in-beaded-fiber tissue engineering fiber support frame. The preparation method has the beneficial effect that in the process of electrostatic spinning, a granular protein grain drug package is embedded in a fiber bead, so that the in-vitro release performances of drugs are improved.

The present invention belongs to the field of environment protecting technology, and is especially one kind of environment protecting fibrous membrane material. The environment protecting fibrous membrane material consists of nanometer TiO2 of 1-55 nm diameter and micron and nanometer fiber of 30-1500 nm diameter, and has pore diameter of 7-350 nm. The environment protecting fibrous membrane material can filter out micron level dust and other impurity, and nanometer level virus and microbes, eliminate chlorohydrocarbon, chlorine-containing organic and other toxic compound, reduce carcinogenic Cr6+ into non-toxic Cr3+, oxidize cyanide into non-toxic CO2, etc, kill Bacillus pyocyaneus, colibacillus, etc, and shield static electricity and ultraviolet ray.

A fibrous microcell structure comprising: (1) an inner electrode, (2) a hollow fibrous membrane separator in contact with the inner electrode, (3) an electrolyte embedded in the hollow fibrous membrane separator, and (4) an outer electrode, wherein at least one of the inner and outer electrodes comprises a metal clad composite having two or more metal layers bonded together by solid-phase bonding. Preferably, such fibrous microcell structure is a fuel cell that comprises inner current collector, an inner catalyst layer, a hollow fibrous membrane separator in contact with the inner catalyst layer and the inner current collector, an electrolyte embedded in the hollow fibrous membrane separator, an outer catalyst layer, and an outer current collector.

The invention relates to a quantitative detection device based on fibrous-membrane gathering and separation and a detection method thereof. The quantitative detection device comprises a separation testing cup, a reaction cup, an analysis buffer solution and a cleaning solution; wherein the separation testing cup comprises a receiving tank, a water absorption cup and millipore filters between them. A capture agent and a labeling agent are solidified on the bottom of the reaction cup and the capture agent is fixed on the surface of latex beads. The detection method comprises: conjugation reaction, separation, cleaning and detection. In the invention, not only the characteristics of convenient operation and rapid detection of immune infiltration (IF) and immunochromatography (IC) are maintained, but also precision and sensitivity of the detection are obviously better than that of IF and IC. Therefore, quantitative immunodetection and nucleic acid hybridization analysis can be implemented effectively. The invention can be used for the quantitative detection of substances such as protein, nucleic acid, small molecule and microbe.

The invention provides an implantation fiber membrane used for female pelvic floor dysfunction tissue repair. The implantation fiber membrane is characterized by comprising a fluffy fibrous layer (A), wherein the fluffy fibrous layer (A) is formed by interweaving cellosilks with the diameters of 10 nanometers-100 micrometers, and is of a porous structure, the filling power is 400-1500 cm<3> / g, and the softness is 50-500 millinewton. Preferably, the implantation fiber membrane further comprises a directed fibrous layer (B), and the directed fibrous layer (B) is a layer which is formed by the directional alignment of the cellosilks and is of a porous three-dimensional structure.

The present invention provides one kind of membranous tissue engineering rack comprising a microporous layer of fiber material in 20-1000 nm pore size and a macroporous layer of sponge or fiber material in 50-1000 micron pore size and communicated to the microporous layer. The tissue engineering rack of the present invention has the beneficial effects of capacity of blocking fibrocyte invasion with the microporous layer and providing inside cell tissue growth space with the macroporous layer; excellent mechanical performance for minimizing the amount of needed biological polymer material and acid degraded product; and suitability for repairing bone, tendon, cartilage, skin and other tissues.

The invention discloses a production method of a cellosilk enhanced compound hollow fiber membrane, which comprises the following steps: by adopting a liquid phase transfer hollow spinning process, firstly, preparing polymer (such as polyether sulfone or polysulfone and the like), solvent and a pore-forming agent into a membrane casting liquid to produce a hollow fibrous membrane; tightly attaching the cellosilk treated by adhesive solution to the outer surface of the prepared hollow fiber membrane; secondly, producing polyvinylidene fluoride or mixture of other polymers, solvent and pore-forming agent into coating liquid of an outer compound layer of the compound hollow fiber membrane; coating the costing liquid outside the hollow fiber membrane to which the cellosilk is attached by using a coating machine to form a compound outer layer; thirdly, feeding into an outer coagulating bath, wherein the solvent, the pore-forming agent and the like in the coating liquid enters liquid phase and the polymers in the coating liquid are precipitated to a polymer compound hollow fiber outer layer due to phase transfer; and finally producing a hydrophilic cellosilk enhanced compound hollow fiber membrane with high strength and high flux.

The invention relates to a method for preparing an enhanced aluminum oxide-based ceramic hollow fibrous membrane. The method comprises the following steps: performing ball milling and mixing a main membrane material aluminum oxide powder and a reinforcing agent, and then drying, grinding and sieving; preparing a polymer solution, adding the evenly mixed ceramic powder in the polymer solution and evenly dispersing to obtain a spinning solution with proper viscosity; after the spinning solution is subjected to deaeration treatment, extruding the spinning solution via a spinning jet, enabling the extruded spinning solution to enter into external coagulated bath by passing through a certain dry spinning procedure, and generating a phase separation process at the moment while forming a hollow fibrous membrane green body; soaking the membrane green body in the external coagulated bath to replace out residual organic solvents; and after naturally drying, processing the green body via a sintering technology to obtain the ceramic hollow fibrous membrane. The invention has simple and convenient technology and no expensive devices, the prepared aluminum oxide-based ceramic hollow fibrous membrane has favorable mechanical property, and the mechanical strength thereof is remarkably improved compared with the hollow fibrous membrane produced by pure aluminum oxide powder.

The invention relates to a method for synchronously performing parallel detection of various biomarkers and a piece of chip test paper. The method comprises the following steps that: a corresponding ligand An is fixed on a fibrous membrane or other fixed solid holders; the various biomarkers n and a ligand Bn form an affinity binding; and simultaneously the biomarkers move on the holders to combine with at least one ligand with a maker so as to form the ligand An, the biomarkers n, the ligand Bn and a signal marker. A conversion step and a calculation step of release signals comprise the following steps that: through the synchronous excitation of various markers on a piece of detected test paper, the markers generate energy jump after the excitation by exciting light and simultaneously release variant light waves or electronic substances; a detecting instrument receives signals of the light waves or electronic transmitters released by the markers and converts the signals into digital signals; and a data processing system calculates the signal data released by the markers and finally outputs the concentration of the biomarkers. The method can synchronously, quantitatively and quickly detect various biomarkers in one sample, shorten the detection time, and improve the sensitivity and the accuracy.

The invention discloses a method for preparing an artificial blood vessel with a micro-nano biomimic intima structure by utilizing an electrospinning technology. The method mainly comprises the following steps of preparing a macromolecular polymer solution; preparing an alignment electrospun fibrous membrane; stretching the alignment electrospun fibrous membrane; preparing an artificial blood vessel; performing characterization by using a scanning electron microscope; and determining blood compatibility. The artificial blood vessel prepared by the method has an intima imitation alignment microstructure, so that the blood compatibility of the artificial blood vessel meets a requirement on clinical anticoagulation performance, and a new way for the preparation of a novel artificial blood vessel is provided. In addition, the adoption of an anticoagulant is avoided, and the blood compatibility of the artificial blood vessel is improved only by a surface microstructure effect, so that side effects caused by the anticoagulant are reduced, and the method has broad application prospect in the field of medical clinical blood vessel transplantation.

The invention discloses a reinforced heat-resistant polylactic acid electrostatic spun fibrous membrane and a preparation method therefor. The electrostatic spun fibrous membrane comprises polylactic acid matrix resin and a composite reinforcing agent, wherein the composite reinforcing agent is a graphene oxide sheet with the surface loaded with a zeolite imidazate framework ZIF-8. The preparation method for the electrostatic spun fibrous membrane comprises the steps of mixing a polylactic acid solution with a certain concentration with an ultrasonic dispersion solution of N'N-dimethylformamide of the composite reinforcing agent according to a ratio by adopting a solution mixing method, and then performing electrostatic spinning under a certain process condition through an electrostatic spinning method to prepare the electrostatic spun fibrous membrane. Compared with a pure polylactic acid fibrous membrane, the electrostatic spun fibrous membrane has the advantages that both the tensile strength and break elongation rate of the polylactic acid fibrous membrane are remarkably improved; the heat resistance of the polylactic acid fibrous membrane is remarkably enhanced; and the electrostatic spun fibrous membrane is biodegradable, safe, reliable, odor-free and low in human body and environmental harm and pollution degree, thereby having wide application values in the fields of biomedicines, packages, textiles, traffic, electronics, electric equipment and the like.

The invention discloses a manufacturing method for a fibrous membrane of an extremely hydrophobic organic macromolecule chemical compound with an oil-water separation function in the technical field of fibrous membrane manufacturing. The manufacturing method comprises the following steps: synthetizing a copolymer with excellent electrostatic spinnability by regulating the compounding ratio of a monomer and controlling the condition of a suspension polymerization technology and by adjusting and controlling the compositions of a solution, processing parameters and the temperature and humidity conditions of environment, and spinning a copolymer solution into the fibrous membrane with the advantages of uniform and small bore diameters, high porosity, large flux and extremely hydrophobic and oleophylic properties by using an electrostatic spinning technique. The obtained fibrous membrane has the advantages that the specific surface area is large, the patterns are large, the stacking structure is proper, and the fibrous membrane is in a three-dimensional bore channel structure. Compared with an existing polymer-based oil-water separation member, the fibrous membrane has the advantages that the bore channel structure is more reasonable, the separation capacity is stronger, the separation efficiency is higher, the anti-pollution capacity is stronger, the membrane bores are not easy to block, the oil-water selectivity is stronger, the mechanical strength is higher, the flexibility and the temperature resistance are better, the preparation process is shorter, the consumed energy is little, the filtering rate is higher, and the cost is lower, so that the fibrous membrane can better satisfy the requirements of industrial practicality.

A pH responsive and mucoadhesive pharmaceutical dosage form for the release of a pharmaceutically active agent is described. The dosage form includes a mucoadhesive layer for site-specific mucoadhesion, a water-insoluble outer layer, and an intermediate layer including one or more pharmaceutically active agents for site-specific delivery. The different membranous layers perform different functions in order to create a drug delivery system which is able to deliver a drug to a specific site, for a particular period of time and with a specific drug release pattern. The dosage form can have two or more intermediate layers, each layer comprising an active agent. The mucoadhesive layer can also include an active agents. The dosage form is preferably an oral or buccal delivery form for release of the active agent into the gastro intestinal tract. The intermediate layer can be an electrospun fibrous membrane layer containing the active agent.

The invention discloses a natural-blood-vessel-simulating three-layer artificial blood vessel stent and a preparation method of the natural-blood-vessel-simulating three-layer artificial blood vessel stent, belonging to the field of tissue engineering. According to the natural-blood-vessel-simulating three-layer artificial blood vessel stent, a polymer material with good biocompatibility is taken as a precursor, after electrostatic spinning, the polymer material forms an inner layer and an outer layer, contacting the cells, of the three-layer artificial blood vessel, good biocompatibility is provided for the artificial blood vessel, a fibrous membrane with good mechanical property is prepared through the electrostatic spinning method, and the fibrous membrane serves as a middle mechanical support layer of the three-layer blood vessel. The prepared three-layer artificial blood vessel stent has good biocompatibility and strong mechanical property. The fibers forming the artificial blood vessel stent have smooth surface, uniform morphology and narrow fiber diameter distribution range, and in addition, the blood vessel is excellent in biological property and mechanical property, and is expected to be applied to the practical clinical diagnosis.

The invention discloses a multi-channel photobacteria on-line water quality toxicity monitoring device and a monitoring method thereof. The device comprises a diaphragm water pump, wherein a water inlet of the diaphragm water pump is connected with a membrane filter through a water pipe and then is connected with a water sample pool; a water outlet of the diaphragm water pump is connected with an overflow type branch sampler through a water pipe; a plurality of water sample monitoring modules form a plurality of monitoring channels which are connected to the overflow type branch sampler; waste liquid outlets of the plurality of the water sample monitoring modules are parallelly connected with an external peristaltic pump; and an outlet of the peristaltic pump is connected to a waste liquid tank. The monitoring method comprises the following steps: a water sample is sucked into the membrane filter consisting of a hollow fibrous membrane by the diaphragm pump, suspensions and bacteria in water are filtered, and the water sample enters the overflow type branch sampler. Then the bioluminescent intensity of photobacteria is detected in a real-time mode through a toxicity detection module. After a detection experiment is finished, the external peristaltic pump discharges a waste liquid in a reactor into the waste liquid tank; and the device can realize the on-line detection of biologic toxicity of the water from water sources, municipal sewage, and input water of water works, and has the characteristics of simple operation, convenient maintenance, high automation degree, and so on.