29 results about "Fibrous membrane" patented technology

The invention provides a 4D printing esophageal stent and a preparation method thereof. The esophageal stent comprises a stent main body and a drug-loaded fiber membrane with a core-shell structure, the stent main body is a tubular stent composed of a bionic water lily hollow structure; the diameters of the head end and the tail end of the support body are larger than the diameter of the middle section, and barb structures are arranged on the outer surfaces of the head end and the tail end. The stent main body is a biodegradable shape memory polymer; the drug-loaded fibrous membrane is positioned on the outer surface of the middle section of the stent main body, and the drug-loaded fibrous membrane contains drugs. The 4D printing esophageal stent provided by the invention has excellent compressive bearing capacity and anti-slip capacity, and the drug-loaded fibrous membrane can avoid esophageal restenosis through long-term uniform slow release of drugs, so that the life safety of a patient can be further guaranteed.

The invention discloses a coronary plaque biomechanical property calculation method, and belongs to the field of computational biofluid mechanics in biomedical engineering. According to the method, the influence of cardiac pulsation, coronary blood vessel complex geometric distribution characteristics and coronary plaque composition factors is integrally considered, and the coronary plaque biomechanical characteristics are calculated; wherein the number of the fluid computational domains is two, and the two fluid computational domains are respectively a coronary vessel intracavity blood flow area and a plaque tissue fluid flow area surrounded by a fibrous membrane and a blood vessel; the two structural computational domains are respectively an elastic blood vessel wall and an ultrathin flexible plaque fiber membrane; the plaque fiber membrane generates deformation movement under the pressure of blood in blood vessels on two sides and tissue fluid in the plaque; the motion of the coronary plaque fibrous membrane is described by adopting an independently researched and developed immersion film method, and compared with a traditional coronary plaque biomechanical characteristic calculation method, the method has better information integrity, better accuracy and wider applicability.

The invention relates to the technical field of biomedical materials, and discloses a 3D printing stent for bone marrow mesenchymal stem cell culture and application of the 3D printing stent, a zinc-magnesium alloy is used as a base material for laser 3D printing, and then fluorinated coating and fiber coating treatment are performed, so that the biocompatibility and the biological activity of the 3D printing stent are remarkably improved, and the 3D printing stent is suitable for being used for bone marrow mesenchymal stem cell culture. Adhesion and growth of bone marrow mesenchymal stem cells are promoted; the magnesium metal and the zinc metal have mechanical properties similar to those of natural bones, can release magnesium ions and promote osteogenic reaction after being implanted into a body, can be completely degraded into non-toxic substances to be discharged out of the body, and are proved to be potential bone substitute materials; the corrosion resistance of the stent is enhanced by the fluorinated coating, the service life is prolonged, and certain antibacterial and anti-inflammatory characteristics are endowed; sodium alginate and collagen components in the fiber coating layer are beneficial to simulation of an extracellular matrix environment, and cell differentiation and osteogenic reaction are further promoted.

The utility model provides a fibrous membrane for guiding periodontal tissue regeneration, and relates to the technical field of medical instruments. Preparing a PLGA double-layer fiber membrane loaded with drug-loaded sodium hyaluronate particles through the cooperative work of electrostatic spinning and electrostatic spraying; the sodium hyaluronate particles can greatly improve the loading rate of hydrophilic anti-inflammatory antibacterial and bone regeneration promoting medicines; a PLGA compact layer in the PLGA double-layer fiber membrane is loaded with first sodium hyaluronate particles loaded with anti-inflammatory and antibacterial drugs, and when the first sodium hyaluronate particles make contact with gingival tissue, cell adhesion and permeation can be hindered, and the anti-inflammatory and antibacterial effects can be achieved; a PLGA loose layer in the PLGA double-layer fiber membrane carries second sodium hyaluronate particles loaded with a bone regeneration promoting medicine, and the second sodium hyaluronate particles can promote osteoblast adhesion and facilitate dentale regeneration when making contact with bone tissue.

The present invention discloses a fiber membrane that promotes the healing of infected wounds, a preparation method and an application thereof. The fiber membrane includes a plurality of non-randomly arranged spinning nanofibers, which are prepared by electrostatic spinning from a material including L-polylactic acid. The porous microstructure of the fiber membrane of the present invention provides a suitable microenvironment for cell migration and epithelial regeneration, and can promote the healing of bacterial-infected wounds. It has been verified that the fiber membrane of the present invention can effectively promote wound healing through antibacterial, relieving inflammation, collagen regeneration and angiogenesis. In addition, the present invention can maximize the antibacterial and tissue repair functions without adding external drugs through ultrasound enhanced treatment, and has broad application prospects.

The application relates to the field of medical devices, in particular to a tracheal cannula end balloon, a preparation method thereof and a tracheal cannula. The tracheal cannula end balloon comprises a balloon body and a double-layer structure arranged on the surface of the balloon body, and the double-layer structure comprises a first nanofiber membrane and a second nanofiber membrane; the first nanofiber membrane comprises a first matrix material and paclitaxel, and the first matrix material comprises polyethylene glycol and polycaprolactone; the second nanofiber membrane comprises a second matrix material and ropivacaine, and the second matrix material comprises polyethylene glycol and polyvinylpyrrolidone. In the application, the double-layer structure design realizes layered release of the drugs, the outer-layer drugs rapidly relieve pain and inflammation, and the inner-layer drugs continuously inhibit cell proliferation, so that the problems caused by the tracheal cannula end balloon are comprehensively solved.

The invention discloses an active polypeptide repair material and a preparation method thereof. The collagen fiber membrane is a fiber membrane prepared by compounding type I collagen extracted from an animal source and type III collagen microspheres containing a placenta extract. The prepared active polypeptide repairing material acts on the skin surface intervened by intense pulsed light after wetting, water-soluble I-type collagen can be transdermally absorbed on a tiny wound surface, fibroblast migration and hyperplasia are stimulated, wound healing is accelerated, meanwhile, III-type collagen and placenta-carrying polypeptide act on the wound surface, and the wound surface can be effectively repaired. The skin elasticity is recovered, less wrinkles are formed, the skin is more elastic, and the effect of delaying senescence is achieved.

The invention discloses an intelligent electric control spraying device and a nanofiber bone repair membrane preparation method. The device comprises a controllable nozzle, a nozzle solution box, a movable guide rail, a speed change gear box, a negative pressure aspirator and a material containing box. Growth factors in gradient concentration distribution are loaded on the repair material by controlling the spraying speed, the advancing speed and the advancing direction, in-situ immersion of the loaded growth factors in the repair material is achieved through negative pressure suction, and through the bidirectional gradient VEGF functionalized absorbable nanofiber bone repair membrane, the concentration of VEGF loaded in the central area is high, and the absorbable nanofiber bone repair membrane has good biocompatibility. The concentration of VEGF loaded to the two ends is gradually reduced, so that neovascular endothelial cells of bone defect broken ends can be guided to directionally migrate to the high-concentration part of the central area of the repair membrane through chemotactic action, and the directional vascularization of bone tissues in a defect area from the two ends to the central area is accelerated; meanwhile, the newly generated blood vessel can be used as a stent to guide cells to quickly migrate and enter a fibrous membrane, so that bone tissue regeneration and repair are efficiently promoted.

The invention provides a fiber membrane for preventing postoperative adhesion and a preparation method thereof, and the fiber membrane comprises the following membrane layers: a degradable polyester layer prepared from degradable polyester and a photoinitiator; and the anti-adhesion membrane layer is prepared from a zwitterionic polymer. The fiber membrane provided by the invention is relatively low in use cost, relatively high in accessibility and excellent in mechanical property. A good anti-adhesion physical barrier is provided for tissues, tissue adhesion can be well prevented, and a simple, convenient and economical novel method is provided for postoperative tissue adhesion prevention.

The invention discloses a special adsorption dressing used after a laparoscopic surgery, and belongs to the technical field of medical dressings. The dressing is of a layered composite structure and sequentially comprises a hydrophilic guide layer, an absorption foam layer and a hydrophobic protective layer from inside to outside, the hydrophilic guide layer is an electrospun fibrous membrane formed by micro / nano fibers oriented along a specific direction; the absorption foam layer is made of a foam material with high aperture ratio; the hydrophobic protective layer is a breathable hydrophobic film; the preparation method mainly comprises the steps of preparation of each functional layer and composite molding through a low-temperature hot pressing process. According to the dressing, through the synergistic effect of the three layers of materials, directional and rapid absorption and storage of percolation of a postoperative puncture hole are achieved, tissue regeneration guidance is provided, the skin around a wound is effectively prevented from being hardened, and the dressing is antibacterial, anti-inflammatory, good in fitting performance and beneficial to wound healing.

The present invention provides a cemented microsphere, a preparation method thereof, and an application. The cemented microsphere provided by the present invention comprises an outer shell layer and a repair core. The outer shell layer is a tightly wrapped fibrous membrane, and the repair core layer comprises a carbonated cementitious material and a carbon dioxide source. When the cemented microsphere is used for carbon dioxide curing and carbonizing products, the system temperature rises, water evaporates, and stress is generated in the inner layer of the product; the fibrous membrane is damaged, and the carbonated cementitious material inside the cemented microsphere reacts with carbon dioxide to generate calcium carbonate crystal nuclei and C-S-H gel with cementing effect, thereby repairing cracks and preventing the product from cracking; the excess carbon dioxide can also react with the carbonated cementitious material inside the product to improve the carbonization degree of the product.

This application discloses an intelligent electronically controlled spraying device and a method for preparing a nanofiber bone repair membrane. The device includes a controllable nozzle, a nozzle solution tank, a moving guide rail, a speed-changing gearbox, a negative pressure suction device, and a material placement box. This application achieves the loading of growth factors with a gradient concentration onto the repair material by controlling the spraying speed, travel speed, and direction. Negative pressure suction allows the loaded growth factors to penetrate the repair material in situ. The absorbable nanofiber bone repair membrane, functionalized with VEGF in a bidirectional gradient, has a high VEGF concentration in the central region, gradually decreasing towards both ends. This chemotactic effect guides newly formed vascular endothelial cells from the bone defect ends to migrate directionally to the high concentration in the central region of the repair membrane, accelerating the directional vascularization of bone tissue from both ends towards the central region. Simultaneously, the newly generated blood vessels act as a scaffold to guide cells to rapidly migrate into the fibrous membrane, thereby efficiently promoting bone tissue regeneration and repair.

The invention provides a rapid hemostasis structure based on multiple adaptation and an application method, and the rapid hemostasis structure comprises a boosting mechanism which is internally provided with a limiting space; the multiple adaptation mechanism is arranged in the limiting space and is in a folded state in the limiting space; wherein the multi-adaptation mechanism comprises a surface supporting part, the surface supporting part is provided with at least two peripheral rods, the peripheral rods are enclosed to form a face type area, and a hemostatic fibrous membrane is arranged on the face type area; the three-dimensional supporting part comprises a center rod and a connecting rod mechanism, and the connecting rod mechanism is hinged to the center rod and the peripheral rods respectively and forms a three-dimensional area; and the elastic piece is connected with the connecting rod mechanism, and the elastic piece is in an energy storage state in the folding state. By means of the hemostasis structure, the problems that an existing hemostasis device is long in hemostasis time and narrow in wound adaptability are solved.

The present application relates to the field of medical devices and discloses a ureteral stent and a preparation method thereof. The ureteral stent comprises a stent body and a nanofiber membrane. The stent body is woven into a 90-140ppi tube by spinning component A and component B in a mass ratio of 4:(1-2). The spun yarn obtained by component B is melted by heating and then combined with the spun yarn obtained by component A. The stent body is obtained after cooling. The nanofiber membrane components include polyethylene glycol and polyglycolide, as well as fucoidan-modified chitosan. A lubricant is sprayed on one side of the nanofiber membrane away from the stent body, and the membrane is wound around the outer surface of the stent body by electrostatic adsorption. The ureteral stent increases the stability and stiffness of the tube wall, improves the mechanical strength and durability, and the material is biocompatible and biodegradable, and can reduce irritation and damage to the urothelium, and prevent urothelial tissue ingrowth and adhesion.

The invention relates to the field of medical instruments, and discloses a ureteral stent tube and a preparation method thereof.The ureteral stent tube comprises a stent tube body and a nanofiber membrane, the stent tube body is formed by blending and weaving a component A and a component B according to the mass ratio of 4: (1-2) into a 90-140 ppi tubular shape, the preparation method comprises the following steps: preparing a component A from a nanofiber membrane, heating to melt the spinning obtained from the component B, combining with the spinning obtained from the component A, and cooling to obtain a stent tube body, the nanofiber membrane comprises polyethylene glycol, polyglycolide and fucoidin modified chitosan, one side of the nanofiber membrane deviating from the stent tube body is sprayed with a lubricant, and the other side of the nanofiber membrane deviating from the stent tube body is sprayed with an antioxidant. According to the ureter stent tube, the stability and rigidity of the tube wall are improved, the mechanical strength and durability are improved, the material has biocompatibility and biodegradability, stimulation and damage to urinary tract epithelium can be reduced, and urinary tract epithelium tissue ingrowth and urinary tract epithelium tissue adhesion are prevented.

This invention discloses a solid electrolyte, its preparation method, and its application. The solid electrolyte comprises a composite of a fibrous membrane and an electrolyte. The fibrous membrane is composed of hollow fibers, each comprising a circumferential fiber wall and a central hollow portion. The fiber wall has a porous structure, and the electrolyte fills the hollow portion of the core and the porous structure of the fiber wall. The porous and hollow structure of the fibrous membrane used in this invention is particularly advantageous for absorbing and storing the electrolyte, while the base membrane also meets the requirement of preventing electrolyte leakage when bent or folded.

Disclosed is a blood oxygenator. The blood oxygenator includes a blood inlet chamber, and a housing. A hollow cavity is arranged in the housing, and includes a heat exchange zone and a gas exchange zone. Multiple heat exchange filaments are arranged in the heat exchange zone. Multiple hollow fibrous membrane fibers are arranged in the gas exchange zone. The blood inlet chamber includes an inverted conical side wall and an end surface hermetically connected to an opening at one end of the inverted conical side wall, an opening at the other end of the inverted conical side wall is hermetically connected to one end of the housing, and the other end of the housing is hermetically connected with a cover body. The cover body is provided with a blood outlet, and the end surface is provided with a spiral liquid inlet pipe coaxial with the blood inlet chamber.

The utility model discloses a fibrous membrane contactor capable of removing carbon dioxide in flue gas, which belongs to the technical field of flue gas filtration, and adopts the technical scheme that the fibrous membrane contactor comprises a separation box, a fibrous membrane structure is arranged on the inner wall of the separation box, a discharge cylinder is arranged on the inner side of the fibrous membrane structure, the separation box is a hollow annular cylinder, and the discharge cylinder is arranged on the inner side of the fibrous membrane structure. Input pipes are arranged on the inner side and the outer side of the separation box, a discharge pipe is arranged on the outer side of the separation box, and an output disc is arranged at the bottom of a discharge barrel, by arranging a matching assembly, flue gas entering the input pipes can be preliminarily filtered, impurities and particulate matter in the flue gas can be preliminarily filtered, and the flue gas can be conveniently discharged; and after flue gas enters the separation box along the input pipe, carbon dioxide permeates the fiber membrane faster than the flue gas, and is discharged through discharge pipes arranged at the top and the bottom of the inner side of the separation box, and collection can be facilitated.

The invention discloses a keratinized gingival repair material as well as a preparation method and application thereof, and belongs to the technical field of periodontology and biomedical materials. A keratogingival repair material body is composed of a material inner layer and a material outer layer, the material inner layer and the material outer layer are nanofiber membranes formed by polycaprolactone, gelatin and sodium hyaluronate, the material inner layer and the material outer layer are matched in interface component, the nanofiber membrane of the material inner layer is of a non-directional structure and simulates an intrinsic layer of keratogingival, and the nanofiber membrane of the material outer layer is of a non-directional structure and simulates the intrinsic layer of the keratogingival. Approaching a tissue surface; the outer layer nanofiber membrane of the material is of a directional structure, simulates the epithelial layer of keratinized gingiva and is close to the oral cavity surface; and the integrated keratinized gingival repair material body is formed. According to the invention, a bionic integrated material structure is established, rapid epithelialization is realized, a wound surface is effectively sealed, and meanwhile, cells can be conveniently spread, migrated and grown on the material; host cells can be guided to construct mature tissues which are close to natural keratinized gingiva in structure and function, and the repair time is shortened; and batch production and clinical transformation application are facilitated.

The invention discloses a drug-loaded fibrous membrane as well as a preparation method and application thereof. The drug-loaded fibrous membrane comprises an active drug and a matrix membrane, the active medicine comprises pecedatinib or pharmaceutically acceptable salt thereof, and the matrix membrane has a fiber structure. The preparation method comprises the following steps: carrying out electrostatic spinning on a spinning solution containing an active drug, a matrix component and a solvent, thereby obtaining the product, wherein the active medicine comprises pecedatinib or a pharmaceutically acceptable salt of the pecedatinib. The drug-loaded fibrous membrane can maintain good physical and chemical properties of the fibrous membrane while loading drugs, can ensure slow release of drugs and significantly inhibit the occurrence of aseptic inflammation problems in practical application, and shows extremely high biocompatibility and safety.

The invention provides a fibrous membrane for preventing formation of uterine scars and a preparation method of the fibrous membrane. The fiber membrane comprises a degradable fiber membrane, nano particles are loaded on the surface of the degradable fiber membrane, and the nano particles are formed by wrapping growth factors with bioactive substances. By regulating and controlling the healing processes of the uterine incision, the regeneration of the uterine muscular layer, the endometrium and the blood vessel is promoted, and the formation of the uterine scar can be well prevented.

This invention discloses a blood purification device and its usage method, relating to the field of medical device technology. A first housing and a second housing directly or indirectly form a hollow inner cavity and are capable of sliding relative to each other along the axial direction. During blood purification, blood flows through the fibrous membrane bundle, while dialysate flows through the inner cavity formed by the first and second housings, resulting in substance exchange between the blood and dialysate. When the fibrous membrane bundle becomes blocked, the first and second housings separate and move relative to each other along the axial direction. The fibrous membrane bundle is elastic, causing it to stretch. The shape of the micropores on the sidewalls of each membrane tube changes, allowing some of the blocking proteins to be squeezed out. When the length of the membrane bundle is restored, the size of the micropores on the sidewalls of each membrane tube is larger than in the initial state, further eliminating the blockage.

This invention provides an oral repair membrane and its preparation method. The oral repair membrane comprises: a substrate, which is formed by interlocking and winding fibers with a diameter of 10 nm-100 μm and has a porous structure; and active particles, which are loaded on the surface and / or inside the substrate, and the active particles are derived from piezoelectric materials and / or hydrophilic polymer materials. The oral repair membrane of this invention has a porous structure with a suitable pore size, which can better shield fibroblasts from growing into the fibrous membrane, avoiding the problem of membrane thickening caused by fibroblast growth. It also has good softness and adhesion, and will not slip during use, avoiding the risk of membrane exposure and reducing the exposure infection rate.

This invention discloses a mold and its preparation method for a membrane-aerogel composite tubular tissue engineering scaffold. The scaffold comprises several layers, several supports, several gaskets, a central core column, and a hollow transparent tube. The supports are used to support the layers. Each layer of the scaffold has at least one annular gasket groove coaxially arranged for fixing the gasket. The central core column is fixed through the central core column positioning holes of the upper and lower gaskets. The hollow transparent tube is fixed through the transparent tube positioning holes of the middle gasket and the transparent tube positioning groove of the lower gasket. This invention also discloses a method for preparing the membrane-aerogel composite tubular tissue engineering scaffold. Using the mold, the axes of the inner tubular fibrous membrane and the outer tubular aerogel are precisely matched, thereby ensuring the stability and integrity of the overall structure and facilitating long-term preservation.

The invention discloses a degradable biological tympanic membrane repair material and a preparation method thereof, and relates to the field of ear tympanic membrane repair technology. The method comprises the following steps: providing a gelatin spinning solution and a cross-linking solution, and forming a regenerated loose fiber membrane with a disordered loose fiber structure by an electrostatic spinning process; wherein the thickness of the regenerated loose fiber membrane is 50-270 μm, the cross-linking degree is 50-90%, and the spinning fiber diameter is 400-600 nm; wherein the gelatin can be a drug-modified gelatin, and the method can further include forming a shielding dense layer by an electrostatic spinning process, and forming a double-layer structure with the regenerated loose fiber membrane layer. The biological tympanic membrane repair material of the present invention can replace autologous tissues such as temporalis fascia to realize tympanic membrane perforation repair, is suitable for a variety of surgical procedures such as butterfly cartilage tympanoplasty, and can provide continuous drug sustained release during tympanic membrane repair to ensure the effect of tympanic membrane regeneration and healing.

The invention provides a method and a device for testing the integrity of a fibrous membrane of a plasma separator, the testing method comprises the plasma separator, the plasma separator is internally provided with an intra-membrane channel and an extra-membrane channel, the intra-membrane channel and the extra-membrane channel are communicated through a membrane hole, and the testing method comprises the following steps: discharging gas in the plasma separator; injecting water into the plasma separator in a transmembrane manner; applying fluctuation pressure to the intra-membrane channel and the extra-membrane channel at the same time; discharging water in the in-membrane channel; testing the integrity of a fibrous membrane in the plasma separator by using a pressure drop method; the device comprises a plasma separator and a fluctuation pressure source, the plasma separator is provided with an intra-membrane channel and an extra-membrane channel, the intra-membrane channel and the extra-membrane channel are communicated through a membrane hole, the plasma separator is connected with a first pipeline and a second pipeline, the first pipeline is communicated with the intra-membrane channel and the fluctuation pressure source, and the second pipeline is communicated with the fluctuation pressure source. The second pipeline is respectively communicated with the out-of-membrane channel and the fluctuation pressure source; the device can effectively and efficiently detect whether the fiber membrane is damaged or not.

Provided are a sub-micron fibrous membrane in which sub-micron fibers aligned along one axis and sub-micron fibers in a random pattern form a network, and a method for producing the sub-micron fibrous membrane.

The application discloses a wet-adhesion nanofiber composite membrane for promoting healing of tooth extraction sockets, a preparation method thereof and application thereof, and comprises the following steps: step one: dissolving a first material in an organic solvent, uniformly mixing to obtain a first solution; step two: dissolving a second material in deionized water and / or an organic solvent, uniformly mixing to obtain a second solution; step three: using an electrospinning technology, electrospinning the first solution in a first syringe to prepare an outer nanofiber membrane; electrospinning the second solution in a second syringe to directly form an inner nanofiber membrane on the surface of the outer nanofiber membrane, and obtain the wet-adhesion nanofiber composite membrane; wherein the first material at least comprises any one of thermoplastic polyurethane and polyacrylonitrile; the second material at least comprises polyacrylic acid; the voltage used in the electrospinning is 10kV-25kV, the receiving distance is 10cm-20cm, and the sample injection rate is 0.3mL / h-1.5mL / h. The wet-adhesion nanofiber composite membrane can promote rapid reformation of gingival epithelium and maintain stable morphology of alveolar ridges through guided bone integration.