203 results about "Oxygenator" patented technology

The embodiment of the invention provides a continuous blood oxygen monitoring system in extracorporeal circulation and a control method thereof. The continuous blood oxygen monitoring system comprises a vein sensor, an artery sensor, a blood flow sensor, an oxygen sensor, a carbon dioxide sensor, a controller and a display, the vein sensor monitors the vein blood oxygen saturation degree; the artery sensor monitors arterial oxygen saturation and hematocrit; the blood flow sensor monitors the blood flow of the artery pipeline; the oxygen sensor monitors the oxygen concentration of the oxygenator; the carbon dioxide sensor monitors the carbon dioxide concentration of the oxygenator; the display provides an interaction control, responds to a trigger operation acting on the interaction control, sends an interaction instruction to the controller, and updates information displayed in an interaction interface according to the control of the controller; the controller receives the interaction instruction and executes processing corresponding to the interaction instruction; the processing includes controlling display information of the display; the display information comprises information corresponding to the monitoring parameters. The scheme ensures the safety and effectiveness of the treatment process.

A blood pump-oxygenator system (250A, 250B, 250C) for increasing perfusion and oxygen levels in the body of a patient (P), comprising: a blood inlet (80) and a blood outlet (90) connected to form a circuit operable as a cardiopulmonary bypass system suitable for extracorporeal treatment of the blood of the patient; a first blood pump (11) and a first oxygenator (20), wherein the first blood pump (11) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the first oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The system further comprises a second blood pump (13) and a second oxygenator (21), wherein the second blood pump (13) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the second oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The circuit comprises a first branch (101) and a second branch (102) arranged in parallel with each other, the first branch (101) accommodating the first blood pump (11) and the first oxygenator (20), and the second branch (102) accommodating the second blood pump (13) and the second oxygenator (21). The system further comprises a pump control unit (290) wherein the first and second blood pumps (11, 13) are configured to be controlled by the pump control unit (290) to increase or decrease the blood flow through the corresponding oxygenator (20, 21) by changing the proportion of the blood flow through the first and second oxygenator (20, 21).

The invention relates to the field of medical instruments, in particular to an extracorporeal membrane oxygenation device with mechanical protection, which comprises a main device and a consumable component, one side of the main device is provided with a connecting piece and a pump head driving seat, and the top of the main device is provided with a protection frame; the consumable assembly is detachably installed on the connecting piece, the consumable assembly is provided with a pump head connected with the pump head driving base, and the protection frame is suitable for forming external protection on the consumable assembly installed on the connecting piece. The oxygenator and the pump head are integrated on the consumable assembly and then installed on the connecting piece of the main equipment in a buckled and matched mode, a mechanical protection frame is formed for the consumable assembly based on the protection frame on the main equipment, the consumable assembly is not prone to being collided by machines in the transferring process, and the transferring safety is improved. The extracorporeal membrane oxygenation device is small in size, light in weight, convenient to operate, very convenient to transfer, and suitable for forming the portable and integrated extracorporeal membrane oxygenation device with mechanical protection, and the extracorporeal membrane oxygenation device is used for being transferred between long-distance hospitals.

The invention discloses a disposable isolated organ continuous oxygenation mechanical perfusion circulation system and a working method. A circulation pipeline of the circulation system is provided with a to-be-carried oxygen conveying pipeline and an oxygen-carrying perfusion pipeline; the output end of the organ low-temperature storage container is connected to the to-be-carried oxygen conveying pipeline, and the pump pipe and the oxygenator are arranged on the to-be-carried oxygen conveying pipeline; the organ transfer sleeve assembly is detachably mounted on the organ tray assembly; the organ tray assembly is arranged in a cavity of the organ low-temperature storage container; the output end of the oxygenator is connected to the oxygen-carrying perfusion pipeline, the automatic bubble separator installed on the oxygen-carrying perfusion pipeline is connected to the input end of the organ transfer sleeve assembly, and the pressure sensor is installed on the oxygen-carrying perfusion pipeline. The device has the following advantages: the device has an automatic bubble removal function; on the basis of a low-temperature mechanical perfusion function, the oxygenation function is achieved; light weight is taken into account, and portable transfer of perfusion equipment is facilitated; the method has higher safety and reliability.

The invention relates to the technical field of human body blood gas monitoring, and discloses a blood gas monitoring method and system of an extracorporeal circulation system.The method comprises the steps that current blood gas data of a patient is collected, cleaning is conducted, blood gas features are extracted, the features are input into a blood gas prediction model, and the change trend of the blood gas data of the patient in the future effective intervention period is predicted; if it is monitored that the blood gas data of the patient tends to be bad in the time period, parameters of the oxygenator are actively adjusted; meanwhile, according to the basic information of the patient and the current blood gas data, a corresponding oxygenation parameter adjustment strategy is screened, the change trend of the blood gas data of the patient is continuously predicted, and whether the oxygenation parameter adjustment strategy is replaced or not is judged according to the updated prediction result until the predicted blood gas data of the patient is in a good change trend; the technical problem that existing blood gas monitoring lacks effective early warning is solved.

The utility model provides a miniature extracorporeal membrane lung oxygenation device which comprises a circulating pump, an oxygenator and a heat preservation device which are respectively arranged on a base, a liquid medium to be tested is filled in the heat preservation device, the liquid medium to be tested is kept at a constant temperature through the heat preservation device, and an outlet end of the heat preservation device is communicated to an inlet end of the oxygenator through a first pipeline. The outlet end of the oxygenator is communicated to the inlet end of the heat preservation device through a second pipeline, a circulating pump is installed on the first pipeline, an oxygen passing hole is formed in the middle of the oxygenator, an air inlet pipe is installed in the oxygen passing hole, and the air inlet pipe is connected to air supply equipment. According to the miniature extracorporeal membrane oxygenation device, blood to be tested is subjected to heat preservation through the heat preservation device, then blood circulation of a human body is simulated in vitro through the circulating pump, important data support is provided for research and development of an ECMO oxygenator, meanwhile, the research and development progress of an ECMO overall sleeve bag can be greatly accelerated, the test cost is reduced, and the test efficiency is improved. The test efficiency is improved.

The invention relates to the technical field of medical monitoring, in particular to a patient cardiopulmonary function monitoring system and method and a computer readable storage medium, the monitoring system comprises a breathing machine, a pulmonary membrane oxygenation device, a first monitoring module and a second monitoring module, and the breathing machine comprises a breathing circuit, a processing module and a display module; the pulmonary membrane oxygenation equipment comprises an oxygenator; the first monitoring module is used for monitoring carbon dioxide exhaling parameters in gas exhaled by a patient in real time; the second monitoring module is used for monitoring carbon dioxide discharge parameters in gas discharged by the oxygenator in real time. By means of real-time monitoring of exhaling parameters of carbon dioxide in gas exhaled by a patient and discharging parameters of carbon dioxide in gas discharged by an oxygenator, continuous monitoring of the change condition of the cardiac function and / or the lung function of the patient is achieved, oxygen consumption of the patient can be truly reflected, parameter adjustment of a breathing machine and lung membrane oxygenation equipment is facilitated, and the patient experience is improved. And guidance is provided for turning of the pulmonary membrane oxygenation equipment.

The invention discloses an organ mechanical perfusion system which comprises a liquid storage container used for storing perfusion liquid; the perfusion pump is used for extracting the perfusion liquid in the liquid storage container and perfusing the organ through the perfusion pipeline; the oxygenator is used for oxygenating perfusate and organs; the temperature control module is used for maintaining the temperature of the organ and the perfusate in a set range; the main control module is used for controlling the perfusion pump and the temperature control module according to the perfusion parameters, controlling the temperature control module to place the organ in a low-temperature state in a first time period, and controlling the perfusion pump to stop perfusion action or perform slow perfusion action in the low-temperature state so as to enter a maintenance stage; and in the second time period, the temperature control module is controlled to place the organ in a normal temperature or sub-normal temperature state, and the perfusion pump is controlled to execute normal perfusion action in the normal temperature or sub-normal temperature state, so that a normal perfusion stage is started. Wherein the maintenance stage of the first time period and the normal perfusion stage of the second time period can be alternately carried out.

The utility model belongs to the technical field of organ transplantation auxiliary equipment, and particularly relates to an animal organ perfusion system and equipment. The animal organ perfusion system comprises a temperature control pipeline loop and at least one perfusion pipeline loop. The perfusion pump, the filter, the oxygenator, the bubble remover, the flow sensor, the pressure sensor and the organ chamber are sequentially connected through the perfusion pipeline. The temperature control pipeline loop comprises a circulating liquid pipeline, and a temperature control device, a temperature sensor, a circulating pump and a bathtub which are sequentially connected through the circulating liquid pipeline. Wherein the bathtub is used for containing circulating liquid, the temperature control pipeline loop is used for regulating and controlling the temperature of the circulating liquid, and the organ chamber is arranged in the bathtub so as to be capable of exchanging heat with the circulating liquid. The animal organ perfusion equipment provided by the utility model is provided with the animal organ perfusion system so as to realize automatic perfusion of organs of small animals. The device is relatively miniaturized, the manufacturing cost is relatively low, and the cost of the small animal organ perfusion experiment is relatively low.

A first chamber and a second chamber are formed between the two ends, in the first direction, of a medium exchange module and a shell, a gas inflow cavity and a heat medium inflow cavity are formed between one end, in the second direction, of the medium exchange module and the shell, and a gas outflow cavity and a heat medium outflow cavity are formed between the other end and the shell. Two ends of the first / third gas exchange pad are respectively communicated with the first and second chambers, two ends of the second gas exchange pad are respectively communicated with the gas inflow / outflow cavity, and two ends of the heat exchange pad are respectively communicated with the heat medium inflow / outflow cavity. The first cavity is communicated with the gas inflow cavity, the second cavity is communicated with the gas outlet, the gas inflow cavity is communicated with the gas inlet, the thermal medium inflow cavity is communicated with the thermal medium inlet, and the thermal medium outflow cavity is communicated with the thermal medium outlet.

The invention belongs to the field of medical equipment, and provides an organ perfusion device, which comprises a liquid storage bin, a perfusion device and a control device, the organ bin is used for storing isolated organs; the pump is used for driving perfusate; the perfusion pipeline is used for perfusion of an isolated organ, is provided with two or more flow division pipelines and is used for perfusion and flow division; the temperature maintaining system is used for maintaining the perfusate and the isolated organ at different temperatures; the oxygenator is used for oxygenating the perfusate; the central control system is used for system control; the perfusion pipeline is driven by the pump to extract perfusion liquid from the liquid storage bin to perfuse the isolated organ in the organ bin. Metabolic waste can be prevented from entering circulation again through one-way perfusion, low-temperature and normal-temperature double-phase automatic switching is achieved, one-way tidal perfusion is achieved, the device structure is obviously simplified, and the overall performance such as safety, stability and portability is improved.

An oxygenation device for use with extracorporeal blood circulation is disclosed. The device includes an oxygenator housing having a blood inlet end cap having a blood inlet opening, a blood outlet end cap having a blood outlet opening, and a gas collector housing between the blood inlet opening and the blood outlet opening. The gas collector housing defines a gas compartment having a gas inlet chamber with a gas inlet port and a gas outlet chamber with a gas outlet port. Heating devices are disposed against the gas collector housing and include a first heating device in the gas inlet chamber and a second heating device in the gas outlet chamber. During operation of the oxygenation device, the heating devices heat the gas compartment.

The utility model discloses an aerator for mixing air, oxygen and liquid, which comprises a shell, a driving mechanism and an oxygen conveying component, and the shell is provided with a water inlet and a water outlet; the driving mechanism comprises a driving unit, a transmission shaft and an impeller, the impeller can drive fluid to be output from the water inlet to the shell and sent out from the water outlet, the transmission shaft is a hollow shaft and is provided with an air inlet and an air outlet which are connected to an inner cavity of the transmission shaft, and the air outlet is located at the position corresponding to the impeller; an oxygen outlet of the oxygen conveying assembly is formed in the position corresponding to the impeller or located on a fluid advancing path, when the impeller drives water to flow, negative pressure can be formed at the air outlet, external air is sucked in from the air inlet, the air is continuously sucked in from the air inlet, and meanwhile the oxygen conveying assembly can be used for conveying oxygen. The oxygen conveying assembly can convey oxygen to be mixed with water flow to further improve the dissolved oxygen amount, air, oxygen and water are fully mixed, and therefore the dissolved oxygen amount of the water body is greatly improved, and the problem of layering of the water body of the fishpond can be well solved.

The invention provides a membrane type oxygenator and an extracorporeal life support system, the oxygenator comprises: a housing assembly, the housing assembly is provided with a liquid inlet, at least two liquid outlets, an air inlet and an air outlet, the housing assembly comprises a first end cover, an outer cylinder and a second end cover which are connected in sequence; the inner cylinder is arranged in the outer cylinder, the inner cylinder and the outer cylinder form an oxygenation cavity, and the inner cylinder is connected with the first end cover to form a liquid separation cavity; and the plurality of oxygenation membrane wires are arranged in the oxygenation cavity. The liquid outlet direction of each liquid outlet is perpendicular to the liquid inlet direction of the liquid inlet. The device can accord with the physiological characteristics of umbilical cord blood vessels of the premature infants, facilitates connection of the oxygenator and is suitable for providing in-vitro life support for the premature infants. Moreover, due to the fact that the flowing path of blood in the oxygenation cavity is minimum, extremely low transmembrane pressure difference is achieved, blood pressure generated by the heart of the premature infant can be directly utilized, and blood extracorporeal circulation can be achieved through the membrane type oxygenator without depending on a blood pump.

An oxygenerator (4) has a blood side (2), a gas side (6) and a semi-permeable membrane (8), where the membrane (8) separates the blood side (2) from the gas side (6), the blood side (2) has an inlet (18) and an outlet (20), the gas side (6) has an inlet (14) and an outlet (16), and during operation of the oxygenerator (4), the gas side (6) has an inlet (14) and an outlet (16). A flow of gas flows into the inlet (14) to the outlet (16) at a gas flow rate and a flow of blood flows into the inlet (18) to the outlet (20) at a blood flow rate, where gas flowing into the inlet (14) of the gas side (6) and blood flowing into the inlet (18) of the blood side (2) flow along the membrane (8) in the same direction to their respective outlets (16, 20).

1. The name of the design product: oxygenation machine (paddle wheel type). 2. The use of the design product: oxygenation equipment for oxygenating water bodies for aquaculture. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The present invention provides an organic fluid oxygenator (10) comprising a container body (20); a first hole (21) for oxygen entry and a second hole (22) for exhaust gas exit; a third hole (23) for entry of organic fluid to be oxygenated and a fourth hole (24) for exit of oxygenated organic fluid; an oxygenation chamber (30) for oxygenating the organic fluid to be oxygenated, defined within the container body (20); and a mass (31) of capillary fibers (32) impermeable to liquids but permeable to gases, arranged parallel to each other in a first direction (X) to be wrapped by the organic fluid within the oxygenation chamber (30).

The utility model provides a portable low-temperature oxygen-carrying organ transfer box which comprises a machine shell and a cover plate, a miniature oxygen generator is installed on the machine shell, two sets of air outlet connectors are arranged on the machine shell, and the miniature oxygen generator is connected with the two sets of air outlet connectors through connecting pipes. The cover plate is rotatably connected with the shell to form a placement cavity, a storage assembly is arranged in the placement cavity, the storage assembly comprises a covering shell, a container bag and an oxygenator are arranged in the covering shell, two groups of oxygen circulation openings are formed in the container bag, one group of air outlet connectors are connected with the oxygenator, and the other group of air outlet connectors are connected with one group of oxygen circulation openings; a control panel is arranged on the machine shell, and a power supply and a main control board are installed on one side of the machine shell. According to the transfer box, the miniature oxygen generator is installed on the machine shell, the miniature oxygen generator is communicated with the oxygenator and the container bag in the storage assembly through the connecting pipe, oxygen can be supplied to organs at low temperature, accumulation of toxic metabolites of the organs is effectively avoided, and the risk of ischemia reperfusion injury is reduced.

A method for controlling carbon dioxide [CO2] removal in a device (5) for extracorporeal blood gas exchange is disclosed. The device (5) comprises an oxygenator (21) including a membrane (23) acting as a gas-liquid barrier enabling CO2 transfer between a bloodstream and a sweep gas flow through the oxygenator. The method comprises the steps of adding (S1) CO2 to the sweep gas flow upstream of the oxygenator (21) to control a degree of CO2 removal from the bloodstream by the oxygenator, determining (S2) a measure of CO2 removal by the oxygenator (21) based on a difference [ΔCCO2blood] between a measure of a pre-oxygenator content of CO2 [CCO2in] in the bloodstream upstream of the oxygenator (21) and an estimate of a post-oxygenator content of CO2 [CCO2out] in the bloodstream downstream of the oxygenator (21), and utilizing (S3) the measure of CO2 removal for improved regulation of the CO2 addition to the sweep gas flow.

Disclosed in the present invention are a disposable continuous oxygenation mechanical perfusion circulation system for ex-vivo organs and a working method. A circulation pipeline of the circulation system is provided with a deoxygenated return line and an oxygenated perfusion line; an output end of a low-temperature organ storage container is connected to the deoxygenated return line, and a pump tube and an oxygenator are arranged in the deoxygenated return line; an organ adapter sleeve assembly is detachably mounted on an organ tray assembly; the organ tray assembly is arranged in a cavity of the low-temperature organ storage container; and an output end of the oxygenator is connected to the oxygenated perfusion line, an automatic bubble separator mounted on the oxygenated perfusion line is connected to an input end of the organ adapter sleeve assembly, and a pressure sensor is mounted on the oxygenated perfusion line. The present invention has the following advantages: the ability to provide an automatic bubble removal function; having an oxygenation function in addition to a low-temperature mechanical perfusion function; being lightweight and being convenient for portable transport of a perfusion apparatus; and having higher safety and reliability.

The present application relates to hollow fiber membrane and its preparation method, membrane lung oxygenator, the membrane structure of hollow fiber membrane comprises from inside to outside: porous layer, dense layer and microstructure layer; the dense layer is arranged on the porous layer, the microstructure layer is arranged on the dense layer, the surface of the microstructure layer away from the dense layer is rough surface. The surface of the hollow fiber membrane has better anticoagulation effect, and it has longer antiplasma leakage time and better oxygenation efficiency.

The invention relates to an organ perfusion device (1), which in one embodiment comprises: a perfusion fluid container (2); an oxygenator (4) in fluid communication with the perfusion fluid container (2) by means of a deoxygenated perfusion fluid supply line (LI) comprising a pump (5); an organ container (3) in fluid communication with the oxygenator (4) by means of a primary oxygenated perfusion fluid supply line (L2) and in fluid communication with the perfusion fluid container (2) by means of a deoxygenated perfusion fluid discharge line (L7) and a seeping perfusion fluid discharge line (L8); and a set (17) of syringe pumps in fluid communication with the perfusion fluid container (2). The primary oxygenated perfusion fluid supply line (L2) comprises an arterial filter (51) in fluid communication with the perfusion fluid container (2), a perfusion fluid heat exchanger (6) with a perfusion fluid temperature sensor, a pH sensor (8), a dissolved oxygen sensor (9), a flow sensor (10) and a pressure transducer (11). The deoxygenated perfusion fluid discharge line (L7) comprises a pressure transducer (21), a throttle valve (22), a dissolved oxygen sensor (23) and a sampling unit (24). The invention also relates to an organ perfusion container (3).

This utility model belongs to the field of oxygenation machine technology, and particularly relates to a spiral propulsion oxygenation machine, including a support frame. A support plate is fixedly connected to the outer wall of the support frame. A screw is provided on the inner wall of the support frame. A lifting frame is threadedly connected to the outer wall of the screw. A support rod is screwed to the outer wall of the lifting frame. A sliding block is screwed to the bottom end of the support rod. A telescopic column penetrating inside the support plate is fixedly connected to the bottom end of the sliding block. A buoy is fixedly connected to one end of the telescopic column. A motor is fixedly connected to the bottom end of the support frame. By setting the telescopic column, the rotation of the screw drives the lifting frame to slide vertically. The sliding of the lifting frame drives the three sets of support rods to move synchronously. This allows the sliding of the lifting frame to drive the telescopic column at the bottom end of the sliding block to slide horizontally along the inner wall of the support plate through the support rod. The sliding of the telescopic column drives the buoy to slide synchronously, thereby increasing the support area of ​​the rotating disk and improving the stability of the rotating disk.

The invention belongs to the technical field of drainage devices, and discloses a pericardial effusion drainage device which comprises an extracorporeal membrane lung oxygenation therapeutic apparatus and a fixing device. The extracorporeal membrane lung oxygenation therapeutic apparatus comprises a main control table, an artificial membrane lung, a centrifugal pump and an oxygenator, an inlet and an outlet of the centrifugal pump are connected with a first catheter and a second catheter respectively, the first catheter is connected with veins of a patient, the free end of the second catheter is connected with the artificial membrane lung, the artificial membrane lung is connected with a third catheter, and the third catheter is connected with the oxygenator. The free end of the third catheter is connected with the artery or vein of the patient; a branch tube of the first catheter is connected with a hydrops catheter, the free end of the hydrops catheter is connected with a drainage tube, and the diameter of the hydrops catheter is smaller than that of the drainage tube. The technical problems that according to an existing drainage mode, effusion cannot be continuously drained, the drainage efficiency is low, the postoperative anemia risk can be increased for a patient with blood loss due to an operation, and the recovery cycle of the patient is prolonged are solved.

The present invention provides an efficient filter oxygenator, which comprises a housing and an oxygenation variable-temperature module. A blood inlet, a water inlet, and a water outlet are formed in the bottom of the housing, an air outlet and a blood outlet are formed in the lower part of the housing, and an air inlet and an exhaust opening are formed in the upper part of the housing. The oxygenation variable-temperature module is vertically arranged in the housing. The oxygenation variable-temperature module sequentially comprises a drainage assembly, a variable-temperature film, a first filter screen, an oxygen pressure film, and a second filter screen from inside to outside. The variable-temperature film is in communication with the water inlet and the water outlet. The oxygen pressure film is in communication with the air inlet and the air outlet. A blood inlet end of the drainage assembly is in communication with the blood inlet, and a blood outlet end thereof is located at the upper part of the variable-temperature film. The hole diameter of the second filter screen is smaller than that of the first filter screen. Blood reaches the upper part of the variable-temperature film from the blood inlet through the drainage assembly, is diffused to the periphery by taking the drainage assembly as the center, obliquely penetrates through the variable-temperature film, the first filter screen, the oxygen pressure film, and the second filter screen from top to bottom, and then flows out from the blood outlet. The present invention achieves a good filtering effect without increasing excessive pressure drop and blood priming volume.

The present invention relates to the field of ECMO technology and provides a blood-heating ECMO circulation kit and a control method thereof. The kit comprises a first blood delivery tube, a blood pump, a second blood delivery tube, a membrane lung oxygenator, a third blood delivery tube, and a human body cannula, which are sequentially connected to form a blood circulation loop; the electrothermal conductive coatings and / or metal wires at the head and tail ends of the first blood delivery tube, the second blood delivery tube, and the third blood delivery tube are all connected to sensors via sensor connectors; the electrothermal conductive coatings and / or metal wires of the first blood delivery tube, the second blood delivery tube, and the third blood delivery tube are connected together and connected to an intelligent heating controller and a plurality of terminators; the intelligent heating controller outputs three-level voltages, and realizes heating, charging, and data acquisition functions through different voltage controls, which is beneficial for observing thrombi and gas emboli in the blood circuit.

An apparatus (1) for determining a CO2 partial pressure value of a blood side (2) of an oxygenator (4) comprises: the oxygenator (4) having a blood side (2), a gas side (6) and a semi-permeable membrane (8), wherein the membrane (8) separates the blood side (2) from the gas side (6), the gas side (6) has an inlet (14) and an outlet (16), and, during operation of the oxygenator (4), a gas flow flows into the inlet (14) to the outlet (16) at a flow rate; a first sensor (10) configured to measure CO2 partial pressure values of the gas side (6); a control unit (12) configured to process the measured CO2 partial pressure values of the gas side (6) and to determine a CO2 partial pressure value of the blood side (2) based on the measured CO2 partial pressure values of the gas side (6), wherein the control unit (12) determines the CO2 partial pressure value of the blood side (2) by calculating a rate of change of the measured CO2 partial pressure values of the gas side (6) during operation of the oxygenator (4), and, when or after the calculated rate of change equals a predetermined rate of change value or falls within a predetermined rate of change range at a predetermined measurement interval, derives the CO2 partial pressure value of the blood side (2) from the CO2 partial pressure value of the gas side (6) measured when or after the calculated rate of change equals the predetermined rate of change value or falls within the predetermined rate of change range.

An oxygenator apparatus for use in an extracorporeal circuit. The apparatus includes a housing and a membrane assembly disposed within the housing. The membrane assembly includes a first plurality of gas exchange elements disposed in a first zone and a second plurality of gas exchange elements disposed in a second zone. The second zone is arranged concentrically around the first zone. The first and second plurality of gas exchange elements are fluidly open along a body and fluidly separated along a distal end. The first zone is configured to be fluidly coupled to an oxygen source and the second zone is configured to be fluidly coupled to a negative pressure source. A blood flow path includes a generally radial flow through the first zone to add oxygen to the blood and the second zone to separate gaseous micro emboli from the blood through the plurality of gas exchange elements.

An apparatus for controlling the supply of oxygenated gas to an oxygenator (140) includes a mixing chamber (161) having an interior volume (165), multiple inlets (162a, 162b), and multiple outlets (167a, 167b). Each inlet is configured to receive a different supply gas, and each outlet is configured to convey oxygenated gas from the interior volume to the oxygenator (140). The apparatus further includes multiple inlet valves (164a, 164b), each disposed between a corresponding inlet and the interior volume of the mixing chamber, and multiple outlet valves (166a, 166b), each disposed between the interior volume of the mixing chamber and a corresponding outlet. The apparatus further includes a controller (150) configured to open and close each of the inlet valves and each of the outlet valves independently of one another.