27 results about "Biological test" patented technology

RFID-based operations management systems and methods are provided herein, particularly RFID based Kanban systems. Such system can realize increased efficiencies, improved visibility of inventory throughout the workflow and improved response to variations in demand. RFID based solutions can automatically transact consumption of Kanban inventory in real-time and trigger replenishment signals to warehouses automatically, resulting in increased Kanban inventory accuracy and lower manual efforts for replenishment and consumption posting. This approach can interface with existing operational management software (e.g. ERP systems, such as SAP) seamlessly integrating with product manufacturing workflows. Such systems are uniquely applicable to manufacture of biological testing kits, where demands fluctuate considerably in response to crises, disasters, epidemics and pandemics.

The invention discloses an experimental device for extracting exosomes, and belongs to the field of biological test equipment. The device comprises a centrifugal machine, a separation mechanism is installed in the centrifugal machine, the separation mechanism comprises a first cylinder, a second cylinder connected to the first cylinder and a third cylinder connected to the second cylinder, a primary sample is placed in the first cylinder, after primary centrifugation, the sample in the first cylinder enters the second cylinder, after secondary centrifugation, the sample in the second cylinder enters the third cylinder, and the sample in the third cylinder enters the third cylinder. The sample in the second cylinder enters the third cylinder; after the device is shut down, the centrifugal cylinder does not need to be replaced for multiple times, multiple centrifugal separation can be achieved only by transferring samples in the three cylinder bodies, and the operation efficiency is improved.

The present invention discloses a series of phenylurea derivative compounds, specifically relating to the compounds as free base, or isomer, or solvate, or pharmaceutically acceptable salt forms; methods of preparing medicaments; compounds composition, and therapeutic uses thereof. The present invention has developed a series of structurally novel compounds based on histamine H3 receptor ligands, and a series of relevant biological tests have been performed on the compounds. The results of the tests all indicate that the compounds have significant H3 receptor antagonistic activity and can be used as lead compounds for the prevention or treatment of H3 receptor-related diseases.

The invention discloses a biological cell culture sampling device for a biological test, which comprises a culture bottle and a sealing cover made of a transparent material, a rotary locking mechanism and a sealing assembly are arranged between the sealing cover and a sampling port in a matched manner, and an electric push rod is fixedly arranged at the upper end of the sealing cover. The piston end of the electric push rod extends into the sealing cover and is fixedly provided with a sampling needle assembly, the side wall of the sealing cover is communicated with a vacuumizing connector and a pressure regulating air inlet valve, an efficient particle air filtering film is arranged in the pressure regulating air inlet valve, and the top of the sealing cover is provided with a suction connector used for being connected with external negative pressure suction equipment. Through cooperation of the rotary locking mechanism and the sealing assembly, reliable sealing of the sealing cover and the sampling opening of the culture bottle is achieved, vacuumizing pretreatment is combined, external air is prevented from entering the culture bottle during puncture sampling, the sterility of a culture system is guaranteed, a main sealing structure of the culture bottle does not need to be opened in the whole sampling process, and the sampling efficiency is improved. And the original stable gas environment in the culture bottle is maintained.

The present application relates to the technical field of biological effect test equipment, and particularly relates to a spatial magnetic field generating device for biological sample test, which comprises a rack, a driving unit arranged on the rack, a magnet assembly rotating driven by the driving unit, and a control system electrically connected with the driving unit, wherein the magnet assembly comprises at least one pair of N-S pole oppositely arranged permanent magnets; the device further comprises a magnetic shielding cover arranged between the driving unit and the magnet assembly. The present application effectively suppresses the eddy current induced by the high-speed rotating permanent magnet in the metal part by introducing the magnetic shielding cover, thereby significantly reducing the operation heat of the device, solving the problem that the stability of the equipment and the environment of the biological sample are affected due to the excessively high temperature rise during long-term continuous work, and simultaneously improving the mechanical stability and the heat dissipation efficiency of the device at high speed through the high-precision dynamic balance calibration and the optimized heat dissipation hole design, so as to provide a more reliable and pure magnetic field environment for biological test.

The invention discloses an osteonecrosis early diagnosis kit based on blood detection and a biomarker, and the osteonecrosis early diagnosis kit can be used for early diagnosis of osteonecrosis through multi-omics screening based on femoral head necrosis lesion division, serological analysis of different stages of cases and cell and animal level biological tests in combination with actual detection result verification. It is determined that a group of biomolecules, namely PEBP1, ACAT1, MMP2, SOD1 and FN1 proteins, can be used for early diagnosis of osteonecrosis.

The invention discloses a method for repairing a probe for a biological test of a terahertz near-field system, and belongs to the technical field of terahertz near-field imaging. According to the method, aiming at the problem that the imaging quality is reduced due to the fact that a probe is polluted by water or water-containing tissues in the biological sample imaging process, the pollution condition is observed through an optical microscope, and two steps of adsorbate separation and adsorbate removal are sequentially carried out. Firstly, a small amount of neutral or weakly acidic solution is dropwise added near a needle tip for dissolution, the solution diffusion range is controlled, and contact with a substrate is avoided; after the adsorbate is separated, a large amount of solution is dropwise added for washing, suction paper is used for sucking dry from the side, and the operation is repeated to ensure that pollutants are completely removed. According to the method, mechanical external force is not needed, operation is safe, simple and reliable, the probe can be effectively repaired, the service life of the probe can be effectively prolonged, and application of a terahertz near-field system in biological imaging is promoted.

The present invention relates to methods and kits for the collection, preservation and storage of analytes of interest present in biological test samples (biofluid samples). In particular, the present invention relates to means to collect the biological test sample such that substantially all pathogen present in the biological test sample is inactivated, while preserving the analyte of interest in a format to allow subsequent analysis.

This invention discloses a biological test strip solution line coating, marking, and cutting device. The device includes: a biological test strip moving and conveying module, a biological solution line coating module, a marking line recognition inkjet module, a control processor, a line scan camera assembly, and an auxiliary material cutting module. The biological test strip moving and conveying module, by controlling the left and right movement of a reciprocating moving platform, can realize the coating, coating detection, position marking, and defect marking of the biological test strip. It can also inspect the marking lines to ensure no marking lines are missed. This device can realize automatic coating, automatic detection, automatic position marking, automatic defect marking and rejection, automatic rejection inspection, and automatic cutting according to requirements of the biological test strip, featuring automated control and a compact structure.

The present application relates to pyrazole derivatives as inhibitors of the PD-1 / PD-L1 interaction. The applicants have designed compounds of general formula (I) wherein R ', R2, y3, R3, R4, R5, R6 and R7 are as defined herein, which are effective in blocking PD-1 / PD-L1 interactions to restore an anti-tumor immune response in a subject and eradicate any tumors in which dormant tumor cells and PD-L1 participate in immune escape. The inventor verifies that these compounds block the PD-1 / PD-L1 interaction by performing physical and chemical tests (MST, NanoDSF) and in vitro biological tests (FRET assay, Pralomig block assay, T cell assay). These compounds have affinity (Kd) in the order of pM, which Kd is higher than the Kd of the antibody Atezumab used in clinical use, and have IC50 comparable to or higher than that observed using Atezumab. Therefore, the invention also relates to a pharmaceutical composition containing the compound and application of the pharmaceutical composition in treatment of PD-1-PD-L1 interaction related diseases (cancers, chronic inflammatory diseases, neurological diseases and chronic infections).

The utility model relates to a kind of anti-toppling medical biological test tube rack, to solve the test tube rack of prior art usually adopts simple flat plate structure, bottom support area is smaller, when test tube is equipped with more liquid or sample with higher gravity center, it is easy to tip over due to slight shaking or external force collision, leading to experimental sample leakage, cross contamination, even cause experimental failure, increase experimental cost and time cost Problem. Rotating support foot and test tube rack piece are rotatably connected, and this flexible connection mode allows the supporting foot to be unfolded or folded according to the actual use scene and space requirement. When stable support is needed, unfold the rotating support foot, and precisely clamp and fix the rotating support foot at the unfolded position with the clamping piece to ensure the stability and reliability of the supporting foot, greatly enhancing the anti-toppling ability of the test tube rack as a whole.

The invention belongs to the field of preparation of metal-polyphenol nano films, and provides application of a metal-polyphenol network loaded metal oxide in fungi. A metal-polyphenol nano-composite is obtained through self-assembly of gallic acid (GA) and Fecl3. 6H2O, and the metal-polyphenol nano-composite is wrapped on the surface of fungal hyphae by adopting a one-step blending method to form a nano-film. The method comprises the following steps: taking tomato early blight fungus hyphae as an object, changing the pH value of a solution, observing the wrapping condition in different time periods, and carrying out microscopic observation and biological test on the wrapped hyphae. The nano-film can provide physical protection for fungi, enhance chemical resistance, regulate growth, promote adhesion, participate in signal transduction and improve disease resistance, can improve the survival rate of fungi, enhance biological activity and improve adhesion capacity and tolerance to drugs, and has important significance in the aspects of agricultural green biological control and food fungi stability.

The anti-cancer agent sensitivity prediction method of the embodiment can include: receiving biological test data based on a cell experiment of a biological sample separated from an individual by a receiving unit; determining, by a processor, the sensitivity of an anti-cancer agent of the individual as a positive treatment response or a negative treatment response based on the biological test data using a sensitivity prediction model; and providing an evaluation result of the sensitivity of the anti-cancer agent of the individual; wherein the sensitivity prediction model is configured to determine the sensitivity of the anti-cancer agent based on an anti-cancer agent response factor and a cell growth factor of a cell experiment.

The invention discloses a full-automatic sample adding fluorescent quantitative PCR instrument based on biological testing, and relates to the technical field of biomedical engineering.The full-automatic sample adding fluorescent quantitative PCR instrument comprises an analysis mechanism, a processing mechanism is arranged in a shell and comprises a connecting block, and two processing tanks are arranged on the upper side of the connecting block; a flow guide shell and a connecting shell are additionally arranged on the upper side of the connecting block, a fan is additionally arranged between the interior of the flow guide shell and the interior of the connecting shell, the remaining two air inlet ends of a communicating pipe communicate with first electric valves, and two air outlets in the top of the other end of the connecting block communicate with second electric valves; by arranging the treatment mechanism, key areas in the instrument can be comprehensively covered and disinfected, meanwhile, disinfection gas left in the instrument can be treated, the disinfection effect is good, and the disinfection effect is good. Therefore, the use efficiency of the full-automatic sample adding fluorescent quantitative PCR instrument based on the biological test is improved.

The invention discloses a construction method and application of an anti-NMDAR encephalitis disease animal model. The construction method comprises the following steps: mixing a GluN1 (359-378) peptide fragment and mycobacterium tuberculosis (Mtb) into an incomplete Freund adjuvant to obtain an emulsified mixture, performing subcutaneous injection to two sides of the back of an anesthetized mouse, and performing intraperitoneal injection of a pertussis toxin (PTX) solution; injecting the PTX solution with the same concentration into the abdominal cavity of the mouse after 48 hours; after 14 days, repeating the first operation to carry out secondary boosted immunization on the mouse; injecting the PTX solution into the abdominal cavity again after 16 days; and after 32-35 days, biological detection is carried out to determine that modeling succeeds. According to the construction method, the period is greatly shortened, and the experiment efficiency is improved; according to the method, through an optimized immune scheme, the model success rate is high, and the phenotype is stable; the model is an active immune model and can simulate a complete disease process from autoantibody generation and immune cell infiltration to central nervous system injury.

The utility model discloses a visual analysis system for identifying and marking biological test paper film solution coating line defects, which comprises a base, a solution coating part and a visual part, a reciprocating motion part is arranged on the base, and the visual part further comprises a solution line defect marking waste ink jet assembly. The reciprocating motion component can move the sheet type biological membrane leftwards or rightwards, when the biological membrane moves rightwards, membrane scratching or metal spraying operation can be completed, then clear or fuzzy solution lines on the biological membrane are judged through the visual component, and the solution lines which do not conform to the membrane scratching and metal spraying standard are recorded as defects. Afterwards, the biological membrane moves rightwards to return to the solution line defect marking waste ink jet assembly, marking waste and mark identification of the defect position are completed, and it is confirmed that the defect is accurately marked. The device has the advantage of being compact, is an upgrade of a platform type film scratching and metal spraying instrument, realizes automatic film scratching and metal spraying, visual judgment and waste marking inspection, can replace manual waste judgment and marking processes for laboratory or small-batch processing, realizes automatic operation, and avoids the problems of long time consumption and poor precision of manual identification and marking.

The utility model provides a cell culture device for biological research and development, which relates to the technical field of auxiliary devices for biological experiments and comprises a main body, a culture bin is arranged in the main body and used for placing a culture dish for culturing cells, and an upper cover for sealing the culture bin is arranged at the top of the main body. According to the device, through the pneumatic control assembly, the pressure and composition of gas in the culture bin can be accurately adjusted, cell growth environments under different physiological conditions are simulated, and the survival rate and growth efficiency of cells are improved. The design of one-way air holes ensures one-way flowing of air, unnecessary air exchange is avoided, controllability of the system is enhanced, external pollution risks are reduced, the temperature control assembly enables temperature distribution in the culture bin to be more uniform, local overheating or supercooling is avoided, and it is ensured that cells grow in a stable temperature environment. The electric heating tubes are distributed at equal intervals, temperature changes can be responded rapidly, it is guaranteed that the temperature reaches and maintains a set value rapidly, and the requirement for rapid temperature adjustment or constant-temperature experiments is met.

Transportable test machine (M) for detecting the presence of an antigen in a sample of biological material, comprising: - a test chamber (3) accessible through a window (2); - a seat (7a) for a tray (V) arranged in the test chamber (3), such tray having at least one sequence of recesses (RO, R1, R2) arranged longitudinally and containing biological test substances; - a motorized membrane holder support (12) arranged in the chamber (3) at a greater vertical height than the seat (7a) so as to be movable upon translation parallel to the sequence of recesses of the tray and vertically with respect to such seat, and the motorized membrane holder support (12) being configured to carry in use a paddle (P) with a functionalized membrane (15) on board on which selective biological molecules are located to select and anchor said antigen to the membrane; and the motorized membrane holder support (12) being also connected in data exchange to an electronic control unit programmed to: ▪ actuate the motorized membrane holder support (12) on the basis of a predefined position variation law to sequentially immerse the functionalized membrane in the recesses of a sequence of recesses of the tray (V) arranged in use in the seat (7a); . receive an image of the functionalized membrane; . process the image by counting the bioluminescent pixels so as to provide a quantitative result of the bioluminescent effect.

The invention discloses a puncture type automatic uniform mixing peripheral blood inoculation instrument and method. The puncture type automatic uniform mixing peripheral blood inoculation instrument comprises a sample bearing platform, a puncture device, a cleaning device and a controller, the sample bearing platform comprises an annular uniform mixing frame capable of rotating along the circumference of a horizontal shaft, and the annular uniform mixing frame is provided with a plurality of assembly stations at equal angles in the circumferential direction and used for loading sample frames and sample pipes. When the annular uniform mixing frame rotates, the sample liquid is convectively stirred under the combined action of centrifugal force and gravity without an additional independent uniform mixing mechanism, so that the uniform mixing effect can be ensured, meanwhile, the equipment occupied space in an inoculation link in a biological test can be reduced, and further uniform mixing of the sample can be realized based on a sample group switching process; the problem of non-uniform sample recovery caused by long-time retention is avoided while the working efficiency is improved, and continuous switching processing of multiple samples can be realized.

The invention discloses a bioassay device and method for common megthrips and application of the bioassay device and method, and relates to the technical field of microminiature insect bioassay, and the bioassay device comprises a transparent cylindrical tube body, a bottom gauze element, a middle gauze element and a tube cover; the inner diameter of the transparent cylindrical tube body is 1.5-2.0 cm, and the height of the transparent cylindrical tube body is 4.0-5.0 cm; the bottom gauze element is arranged at an opening in the bottom of the pipe body; the aperture of the bottom gauze element is smaller than the size of a common megalustris megalustris test insect; the middle-layer gauze element is arranged in the tube body and divides an inner cavity of the tube body into an upper layer and a lower layer, the aperture of the middle-layer gauze element is larger than the size of a common megalurothrips megalurothrips test insect, and the middle-layer gauze element is used for placing a medicament carrier; the pipe cover is arranged on the top of the pipe body in an openable and closable mode. The device is simple in structure, convenient to operate, stable in environment and good in repeatability, and can meet the requirements of indoor efficient and accurate drug toxicity determination and screening.

The utility model relates to a biological test tube storage cabinet, a main body is a test tube storage mechanism, and the test tube storage mechanism comprises a storage cabinet body; the front side of the storage cabinet body is provided with a storage control panel and is provided with an electric control sealing door. The left side and the right side of the storage cabinet body are each provided with a heat dissipation net. A test tube storage cavity is formed in the storage cabinet body, a plurality of test tube storage assemblies are installed in the test tube storage cavity, and a storage cooling assembly used for cooling the test tube storage assemblies is further installed in the storage cabinet body. According to the biological test tube storage device, the biological test tubes can be stored and taken, limiting placement of the biological test tubes is facilitated, the storage convenience of the biological test tubes is improved, meanwhile, the stored biological test tubes can be cooled and stored, refrigeration treatment of the biological test tubes is facilitated, the storage quality of the biological test tubes is improved, and the practicability of the device is improved.

The invention discloses a fully-integrated wireless microfluidic immunosensing system which is used for portable detection of staphylococcus aureus. The fully-integrated wireless microfluidic immunosensing system comprises a bendable biological test strip and an electronic module, wherein the biological test strip comprises a microfluidic module and an immunosensing module; the immune sensing module comprises a substrate and an immune sensing layer arranged on the substrate, and a working electrode, a reference electrode and a counter electrode are arranged on the immune sensing layer; the micro-fluidic module comprises a sealing layer, a spacing layer for storing a liquid sample and a pump-free layer for transporting liquid; a fluid inlet and a fluid outlet are formed in the sealing layer; the micro-fluidic module is compounded on the immune sensing module, and an insulating layer is arranged between the pump-free layer and the immune sensing layer. The method shows huge potential and attraction to food and environment safety monitoring.

The utility model relates to a vehicle-mounted high-hazard biological protection sterilization device which comprises a clean bench, a high-pressure steam sterilizer and a three-stage biological safety cabinet which are sequentially arranged in a vehicle cabin, two sides of the high-pressure steam sterilizer are provided with sealing doors, and the two sealing doors are respectively communicated with the clean bench and the three-stage biological safety cabinet. At least one circle of sealing strip is arranged between the sealing doors and the high-pressure steam sterilizer, electromagnetic locks are arranged on the sealing doors, and detection switches for detecting the opening and closing states of the sealing doors are arranged in the high-pressure steam sterilizer. After a biological test is carried out on the three-stage safety cabinet, test instruments are put into the sterilizer, and after the sterilizer is independently operated to disinfect and sterilize the instruments, the instruments are taken out from the side of the ultra-clean workbench, so that the leakproofness between the three-stage safety cabinet and the ultra-clean workbench is ensured, and germs of an experimental part are prevented from flowing out.

The invention relates to the technical field of constant-temperature incubators, in particular to a constant-temperature incubator for biological examination, comprising: an incubator body for constant-temperature culture of seeds; the incubator body sealing assembly is mounted on the incubator body and is used for sealing the incubator body; the in-box partitioning assembly is movably installed in the incubator body and used for partitioning the internal space of the incubator body, a heat insulation partitioning plate is movably installed in the incubator body, and when the interior of the incubator body needs to be subjected to partitioned culture, the heat insulation partitioning plate is used for partitioning the internal space of the incubator body; the heat insulation partition plate can move to the middle position of the incubator body to achieve partition of the interior of the incubator body, and when partition of the interior of the incubator body is not needed, the heat insulation partition plate can move to one side of the interior of the incubator body.

Relates to a polyethylene glycol micromolecule medicine and a preparation method and application thereof. Specifically, the invention relates to a compound as shown in a formula I or pharmaceutically acceptable salts thereof, intermediate compounds as shown in a formula II and a formula V thereof, a method for preparing the compound, and an application of the compound in tumor resistance. Biological tests show that the compound has a remarkable inhibiting effect on tumors such as breast cancer, intestinal cancer, non-small cell lung cancer, melanoma, oral squamous cell carcinoma and osteosarcoma.

The utility model relates to an infectious specimen processing and preserving bottle belongs to medical biological test technology field, the utility model discloses a bottle body and sterilization liquid storage cover, the sterilization liquid storage cover includes connecting cylinder and storage cylinder, the connecting cylinder is cylindrical structure, and the lower port is connected with the bottle body, and the bottom is equipped with the liquid leakage board A, and the liquid leakage board A is located the top of bottle body, the storage cylinder is the sealed cylindrical cavity structure, and the storage cylinder sleeve connects the connecting cylinder in, and the bottom of storage cylinder is equipped with the liquid leakage board B, and the liquid leakage board B is located the top of bottle body, the utility model discloses the liquid leakage board B is equipped with the liquid leakage B on, the liquid leakage A and the liquid leakage B can be up and down and face each other, the utility model discloses before detecting need not to open sample bottle to be able to realize the sterilization liquid to add sample bottle, whether is the period of preservation, or after the sterilization liquid adds, can make the sample keep good seal, effectively avoided the pathogen release, avoided or reduced the risk of infection of detection personnel.

The invention discloses a composition containing emamectin benzoate and spinetoram, a preparation and application of the composition and the preparation. The microemulsion comprises an active component, a conventional auxiliary agent and a key functional systemic accelerator. An organic silicon surfactant (such as Silwet L-77) and methylated vegetable oil (such as Pro-MSO) are compounded according to a specific proportion to serve as a functional uptake accelerant, the combination can generate a synergistic effect, and uptake conductivity of active ingredients in plants is remarkably improved. Indoor biological assay results show that the LC50 value of the preparation is reduced by more than 50% compared with that of a traditional formula; field pharmacodynamic tests prove that under the condition of the same dosage of the effective components, the control effect on the eggplant thrips reaches up to 95% or above, and the persistence is excellent. According to the invention, through innovative optimization of an auxiliary system, synchronous improvement of the pesticide utilization rate and the control effect is realized, and an effective scheme is provided for developing a novel pesticide preparation which is efficient, low in dosage and capable of delaying resistance.