143 results about "Biological test" patented technology

The invention relates to the technical field of cell culture equipment, and discloses biological cell culture equipment for biological experiments, which comprises a box body and a frame body, the frame body is mounted in the box body through a bracket, a plurality of partition plates are fixedly connected in the frame body, and the plurality of partition plates divide the frame body into a plurality of culture chambers; a plurality of uniformly distributed placing tables are fixedly connected in the plurality of culture chambers, culture dishes are arranged on the placing tables, two sliding seats are fixedly connected in the box body, a transverse moving mechanism is jointly connected in the two sliding seats, the transverse moving mechanism is provided with a base, a vertical pipe is mounted at the upper end of the base, and a lifting assembly is mounted in the vertical pipe. According to the biological cell culture equipment for the biological test, various cells can be cultured in different areas in different culture environments, a technician can be conveniently assisted to take and place a culture dish during culture, the equipment does not need to be opened to take out the culture dish to observe the culture progress of the cells in the culture process, and the stable culture environment in the equipment is not influenced.

A biological test system has receptacles for a variety of removable electro-mechanical biological blood test-based elements having multiple features such as lancets or strips. Testing is through an analysis biological test processor that provides results to a user test output with all designed to be contained in a pocket-transportable user biological test form factor that houses all elements. Biological test elements can be interchanged for multiple sensing modalities with automatic activation based on cartridge insertion of a glucose test element, an A1C test element, a ketone test element, or the like. Designs can include a user sampler configuration selector for a user sampling selection that may be analyzed so a user-personalizable, biological sampler control processor can automatically disable operation for test safety if a user sampling selection is determined to be unacceptable. The system can also provide a user cartridge action prompt, a user reselection prompt, or other action to clear the disable.

The utility model discloses a biological test tube clamping device. The biological test tube clamping device comprises a base, the bottom end of the fixing rod is fixedly connected with the top of the base; the connecting frame is arranged above the base; the test tube bottom support is mounted at the bottom of the connecting frame; and the clamping assembly comprises two clamping mechanisms, a threaded rod and a bolt, the outer surface of one clamping mechanism is fixedly connected with the top of the connecting frame, one end of the threaded rod is fixedly connected with the interior of the clamping mechanism, and the outer surface of the threaded rod is slidably connected with the interior of the other clamping mechanism. According to the scheme, the base, the fixing rod, the connecting frame, the test tube bottom support and the clamping assembly are arranged, the bottom end is placed on the test tube bottom support, the bolt is screwed, one clamping mechanism gets close to the other clamping mechanism, the clamping plates clamp the test tubes, the clamping diameter of the clamping device can be adjusted according to the test tubes of different specifications, the test tubes are stably clamped, and the clamping efficiency is improved. And the effect of improving the applicability of the device is achieved.

The invention discloses an optimization method for microscopic counting of free viruses in farmland soil, and belongs to the technical field of biological tests. According to the method, the test is carried out from the aspects of instrument selection, parameter setting, soil sample usage amount and microscopic observation key influence factors in the soil virus extraction test; analyzing the proportion of the farmland soil sample to the virus leaching solution, different oscillation instruments and parameter setting, and the influence of an anti-fluorescence quenching agent and an anti-fading solution in microscopic observation on the soil virus extraction efficiency and microscopic counting, and optimizing the farmland soil free virus microscopic counting process according to the analysis result. The invention provides an operation process suitable for the farmland soil virus fluorescence staining-microscopic counting method from instrument selection and parameter setting in soil virus extraction, soil sample usage amount and key influence factor control in microscopic observation. And a feasible technical reference can be provided for subsequent quantitative analysis and infection mode research of soil viruses.

RFID-based operations management systems and methods are provided herein, particularly RFID based Kanban systems. Such system can realize increased efficiencies, improved visibility of inventory throughout the workflow and improved response to variations in demand. RFID based solutions can automatically transact consumption of Kanban inventory in real-time and trigger replenishment signals to warehouses automatically, resulting in increased Kanban inventory accuracy and lower manual efforts for replenishment and consumption posting. This approach can interface with existing operational management software (e.g. ERP systems, such as SAP) seamlessly integrating with product manufacturing workflows. Such systems are uniquely applicable to manufacture of biological testing kits, where demands fluctuate considerably in response to crises, disasters, epidemics and pandemics.

The invention discloses an experimental device for extracting exosomes, and belongs to the field of biological test equipment. The device comprises a centrifugal machine, a separation mechanism is installed in the centrifugal machine, the separation mechanism comprises a first cylinder, a second cylinder connected to the first cylinder and a third cylinder connected to the second cylinder, a primary sample is placed in the first cylinder, after primary centrifugation, the sample in the first cylinder enters the second cylinder, after secondary centrifugation, the sample in the second cylinder enters the third cylinder, and the sample in the third cylinder enters the third cylinder. The sample in the second cylinder enters the third cylinder; after the device is shut down, the centrifugal cylinder does not need to be replaced for multiple times, multiple centrifugal separation can be achieved only by transferring samples in the three cylinder bodies, and the operation efficiency is improved.

The invention concerns a remote medical-diagnosis system comprising 1) a self-sampling medical device, 2) at least one reception device, 3) at least one analysis device; and 4) a server configured to register a subject and his biological analysis request, to record the data related to the self-sampling medical device and its associated biological sample, to select at least one biological test to be realized on the self-sampling medical device, to request the at least one analysis device for performing the at least one selected biological test; to receive the data corresponding to the results of the at least one selected biological test performed by the at least one analysis device on the self-sampling medical device and produce and transmit to the subject a report comprising these results and / or eventually request a medical appointment for the subject.

The present invention discloses a series of phenylurea derivative compounds, specifically relating to the compounds as free base, or isomer, or solvate, or pharmaceutically acceptable salt forms; methods of preparing medicaments; compounds composition, and therapeutic uses thereof. The present invention has developed a series of structurally novel compounds based on histamine H3 receptor ligands, and a series of relevant biological tests have been performed on the compounds. The results of the tests all indicate that the compounds have significant H3 receptor antagonistic activity and can be used as lead compounds for the prevention or treatment of H3 receptor-related diseases.

The invention relates to the technical field of biological test waste treatment, in particular to a microbial test waste incineration device which comprises a furnace body, a motor and a transmission rack, flame throwers which are symmetrically arranged are fixedly installed on the furnace body, the output end of the motor is fixedly connected with a driving gear, two rotating rods are rotationally connected to the furnace body, and the two rotating rods are fixedly connected with the transmission rack. Driven gears are fixedly connected to the positions, corresponding to the driving gears, of the rotating rods, half gears are fixedly connected to the positions, corresponding to the interior of the furnace body, of the rotating rods, a guide block is fixedly connected to the position, corresponding to the middle of the two rotating rods, of the interior of the furnace body, and a guide groove is formed in the position, corresponding to the guide block, of the transmission rack; the garbage incinerator has the beneficial effects that due to the flexibility of the crowbar, the incineration efficiency of inspection waste can be improved, the incineration uniformity of the inspection waste can be effectively improved, and the whole incinerator is simple in structural composition, convenient to use and worthy of application and popularization.

The invention discloses a biological cell culture sampling device for a biological test, which comprises a culture bottle and a sealing cover made of a transparent material, a rotary locking mechanism and a sealing assembly are arranged between the sealing cover and a sampling port in a matched manner, and an electric push rod is fixedly arranged at the upper end of the sealing cover. The piston end of the electric push rod extends into the sealing cover and is fixedly provided with a sampling needle assembly, the side wall of the sealing cover is communicated with a vacuumizing connector and a pressure regulating air inlet valve, an efficient particle air filtering film is arranged in the pressure regulating air inlet valve, and the top of the sealing cover is provided with a suction connector used for being connected with external negative pressure suction equipment. Through cooperation of the rotary locking mechanism and the sealing assembly, reliable sealing of the sealing cover and the sampling opening of the culture bottle is achieved, vacuumizing pretreatment is combined, external air is prevented from entering the culture bottle during puncture sampling, the sterility of a culture system is guaranteed, a main sealing structure of the culture bottle does not need to be opened in the whole sampling process, and the sampling efficiency is improved. And the original stable gas environment in the culture bottle is maintained.

The invention discloses a method for predicting combined toxicity of a graphene-based material and ionic liquid. The method comprises the following steps: obtaining an adsorption coefficient through an adsorption experiment of the graphene-based material on the ionic liquid; establishing a concentration-reaction relationship of a binary mixture composed of the graphene-based material and the ionic liquid to a specific ecological species, and obtaining a mean effect concentration of the binary mixture; fitting the adsorption coefficient and the mean effect concentration through a machine learning algorithm to obtain a fitting relationship, and obtaining a quantitative structure-activity relationship model according to the fitting relationship; and inputting a to-be-detected adsorption coefficient serving as an input variable into the quantitative structure-activity relation model to obtain the combined toxicity of the binary mixture on the specific ecological species. The adsorption coefficient is used as the characteristic parameter corresponding to the toxicity data, so that the characteristic parameter is easier to obtain, and the time, manpower, material and other costs caused by biological testing when the average effect concentration is obtained are avoided; and through a machine learning method, a fitting relation is constructed, and prediction can be more efficient and accurate.

The invention belongs to the technical field of medicines, and relates to an aromatic ring thiazine derivative, in particular to structural forms such as free alkali, isomeride and pharmaceutically acceptable salt form of the compound. Methods for preparing such compounds; compositions comprising such compounds and therapeutic uses thereof. Based on a histamine PI3K delta receptor ligand, a series of compounds with novel structures are developed, a series of related biological tests are carried out on the compounds, and test results show that the compounds find novel PI3K delta high-selectivity inhibitors, have the characteristics of small toxic and side effects and low bioavailability, and have broad application prospects. The pharmaceutical composition is used for developing inhaled medicines suitable for treating respiratory system diseases such as asthma and COPD, and has important clinical significance and social value.

The invention discloses a microplate reader for a biological test, and relates to the technical field of microplate readers, the microplate reader comprises a microplate reader body, a carrier plate frame and a porous plate, the carrier plate frame is provided with a placing groove, a gap exists between the porous plate and the inner wall of the placing groove, and a first elastic assembly is arranged in the carrier plate frame; the first elastic assembly comprises a first fixing piece, a first elastic bent piece and a limiting piece, the limiting piece is provided with a second elastic assembly, and the second elastic assembly comprises a second fixing piece, a second elastic bent piece and a pressing piece. The gap between the outer side wall of the perforated plate and the inner side wall of the containing groove is utilized for facilitating taking and placing of the perforated plate, the first elastic assembly is used for limiting the perforated plate in the horizontal direction, and the second elastic assembly is used for limiting the perforated plate in the vertical direction; the perforated plate can be smoothly taken and placed on the plate carrying frame, and meanwhile the placing stability of the perforated plate is improved.

A method for evaluating a biological sample is disclosed. The method includes; (i) receiving the biological sample in a container comprising a first volume, wherein the container comprises a diluent mixture comprising a diluent and a surfactant; (ii) generating a biological testing sample in the container, wherein the biological testing sample comprises the biological sample and the diluent mixture, and wherein the biological testing sample comprises a second volume; (iii) depositing the biological testing sample from the container into a reservoir of a cartridge, wherein the reservoir is configured to receive the biological testing sample, and wherein the reservoir comprises a third volume; and (iv) analyzing the biological testing sample, wherein analyzing the biological testing sample comprises capturing one or more images of the biological testing sample from an imaging sensor of an imaging device.

The invention discloses a platinum (IV)-internal peroxy prodrug molecule and application thereof, and belongs to the technical field of biological medicine. The series of molecules are characterized by being Pt (IV) complexes modified by internal peroxide and mitochondrial targeting groups. The synthesis method sequentially comprises the following steps: carrying out oxidation and hydroxyl modification on a platinum drug, introducing a mitochondrial targeting group and a singlet oxygen carrier through an esterification reaction, and carrying out a photosensitive reaction to prepare the endoperoxide. The series of molecules are reduced into Pt (II) drugs in a tumor microenvironment, singlet oxygen is released at the same time, a mitochondrial targeting group can accurately deliver the treatment molecules, and cancers are efficiently treated. A representative molecule Oxa-EM is selected for instance analysis, the molecule generates a Pt (II) complex with anticancer activity while releasing singlet oxygen, and the singlet oxygen-Pt combined anticancer purpose is achieved. Probes DPBF and SOSG are selected to prove that the molecule releases singlet oxygen, and high performance liquid chromatography is utilized to successfully prove that the Pt (II) complex is released in a reducing environment. Further cell and animal level experiments verify that the molecule has excellent anti-tumor efficacy and safety. The invention discloses design, synthesis and biological test of platinum (IV)-peroxy prodrug molecules, and the platinum (IV)-peroxy prodrug molecules have a wide anticancer application prospect.

The present invention discloses a series of structurally novel histamine H3 receptor antagonists, specifically relating to the compounds as free base, or isomer, or solvate, or pharmaceutically acceptable salt forms; methods of preparing medicaments; compounds composition, and therapeutic uses thereof. The present invention has developed a series of structurally novel compounds based on histamine H3 receptor ligands, and a series of relevant biological tests have been performed on the compounds. The results of the tests all indicate that the compounds have significant H3 receptor antagonistic activity, and can be used as lead compounds for the prevention or treatment H3 receptor-related diseases.

The invention relates to a polyethylene glycol medicine as well as a preparation method and application thereof. Specifically, the invention relates to a compound as shown in a formula I or pharmaceutically acceptable salt thereof, an intermediate compound as shown in a formula II-XX, a method for preparing the compound, and an application of the compound in tumor resistance. Biological tests show that the compound has a remarkable inhibition effect on tumors such as breast cancer, non-small cell lung cancer, melanoma, oral squamous cell carcinoma and osteosarcoma.

The present application relates to the technical field of biological effect test equipment, and particularly relates to a spatial magnetic field generating device for biological sample test, which comprises a rack, a driving unit arranged on the rack, a magnet assembly rotating driven by the driving unit, and a control system electrically connected with the driving unit, wherein the magnet assembly comprises at least one pair of N-S pole oppositely arranged permanent magnets; the device further comprises a magnetic shielding cover arranged between the driving unit and the magnet assembly. The present application effectively suppresses the eddy current induced by the high-speed rotating permanent magnet in the metal part by introducing the magnetic shielding cover, thereby significantly reducing the operation heat of the device, solving the problem that the stability of the equipment and the environment of the biological sample are affected due to the excessively high temperature rise during long-term continuous work, and simultaneously improving the mechanical stability and the heat dissipation efficiency of the device at high speed through the high-precision dynamic balance calibration and the optimized heat dissipation hole design, so as to provide a more reliable and pure magnetic field environment for biological test.

The utility model relates to the technical field of biological test equipment, in particular to a small rodent ectoparasite combing and separating box which comprises a bottom plate, a top cover and a plurality of side plates, the side plates define the side wall of the combing and separating box, and the two sides of the side wall are respectively provided with an operation glove extending into the combing and separating box. The bottoms of the side plates are connected with the bottom plate in a clamped mode, the tops of the side plates are connected with the top cover in a clamped mode, and the adjacent side plates are connected in a clamped mode. According to the comb-off box for the ectoparasites of the small rodents, the side plates are connected with the bottom plate and the top cover in the clamped mode respectively, the adjacent side plates are connected in the clamped mode, in the non-use state, the bottom plate, the top cover and the side plates can be detached from one another, carrying is convenient, and in the use state, the comb-off box is convenient to use. The bottom plate, the top cover and the plurality of side plates can be quickly clamped and connected according to set steps to form the combing box, and the operation is simple and convenient.

The present disclosure pertains to a microorganism testing method includes an adsorption step for adsorbing microorganisms in a liquid sample to particles, a seeding step for seeding the particles to which the microorganisms are adsorbed in a culture medium, and a culture step for culturing the microorganisms on the culture medium.

The invention discloses an osteonecrosis early diagnosis kit based on blood detection and a biomarker, and the osteonecrosis early diagnosis kit can be used for early diagnosis of osteonecrosis through multi-omics screening based on femoral head necrosis lesion division, serological analysis of different stages of cases and cell and animal level biological tests in combination with actual detection result verification. It is determined that a group of biomolecules, namely PEBP1, ACAT1, MMP2, SOD1 and FN1 proteins, can be used for early diagnosis of osteonecrosis.

The invention discloses a biological test tube ultrasonic cleaning device and method. The biological test tube ultrasonic cleaning device comprises a base, a rack is fixedly mounted on the base, a cleaning box is fixedly mounted on the rack, a bearing frame is movably clamped in the cleaning box, a plurality of mounting grooves used for clamping test tubes are formed in the bearing frame, and a first rotating shaft is rotationally mounted on the rack; a rotating shaft is rotatably mounted on the cleaning box, a rotating rod is fixedly mounted on the rotating shaft, a cleaning brush is fixedly mounted on the rotating rod, and the rotating shaft is in transmission connection with the first rotating shaft through a gear transmission mechanism; and a second rotating shaft is rotationally mounted on the rack. The invention relates to the technical field of test tube cleaning devices, and discloses a biological test tube ultrasonic cleaning device and a cleaning method, the inner wall of a test tube in the ultrasonic cleaning process can be subjected to rotary brushing cleaning treatment, the adhesion of dirt on the inner wall of the test tube is effectively reduced, the effect after test tube cleaning is improved, and meanwhile, the test tube cleaning treatment efficiency is also improved.

The invention provides a biological safety cabinet with a filtering structure, and relates to the technical field of biological safety cabinets, the biological safety cabinet comprises a biological safety cabinet, the bottom of the inner side wall of the biological safety cabinet is provided with a liquid leakage groove, and the cross section of the liquid leakage groove is trapezoidal; a first filtering frame, a second filtering frame and a third filtering frame are sequentially installed in the liquid leakage groove from top to bottom, a first disinfection frame is installed in the biological safety cabinet, first motors driving the first disinfection frame to ascend and descend are arranged on the left side and the right side of the first disinfection frame, and spraying is conducted through spraying faucets; the first disinfection frame moves downwards to drive the side supporting frame on the back face to move downwards, the side supporting frame moves downwards to drive the cleaning roller and the cleaning shovel to wipe the inner wall of the biological safety cabinet, and meanwhile the spraying faucet sprays disinfectant to disinfect the inner wall of the biological safety cabinet. Therefore, manual disinfection is not needed, and the safety after the biological test is used is greatly improved.

A kind of decapping device, this decapping device can be combined with automated biochemical analyzer or biological testing system to facilitate sample testing.Exemplary decapping device includes a motor, which can operate: lowering a latch mechanism to engage with the lid of a sample tube, and then raising the latch mechanism to remove the engaged lid.As the latch mechanism is lowered, the tractor portion also descends and causes a group of grippers to extend and clamp the sample tube.As the latch mechanism is raised, the group of grippers apply corresponding pressure to keep the sample tube in place while the lid is removed.Once removed, the lid is resting in the latch mechanism, and the group of grippers is retracted by the raised tractor.When the latch mechanism returns to its initial position, the ejector arm is operated, causing the lid to be ejected from the latch mechanism.

The present invention discloses an optimization method for microscopic counting of free viruses in farmland soil, which belongs to the field of biological test technology. The method conducts experiments from several aspects, including instrument selection, parameter setting, soil sample usage, and key influencing factors of microscopic observation in soil virus extraction experiments, analyzes the effects of the ratio of farmland soil samples to virus extracts, different oscillating instruments and parameter settings, and anti-fluorescence quenchers and anti-fading solutions on soil virus extraction efficiency and microscopic counting in microscopic observation, and optimizes the process of microscopic counting of free viruses in farmland soil based on the analysis results. The present invention can start from the instrument selection and parameter setting, soil sample usage, and key influencing factors in microscopic observation in soil virus extraction, and propose an operating procedure suitable for fluorescent staining-microscopic counting of farmland soil viruses, which can provide a feasible technical reference for subsequent quantitative analysis of soil viruses and research on infection modes.

The invention discloses a benzoheterocycle compound, and particularly relates to structural forms such as free alkali, an isomer, a solvate and a pharmaceutically acceptable salt form of the compound. Methods for preparing such compounds; compositions comprising such compounds and therapeutic uses thereof. Based on a histamine H3 receptor ligand, a series of benzoheterocycle compounds with novel structures are developed, a series of related biological tests are performed on the compounds, and test results show that the compounds have remarkable H3 receptor antagonistic activity and can be used as lead molecules for preventing or treating diseases related to H3 receptors.

Provided herein is a method, apparatus, and system for an electronic surrogate that comprehensively tests light output and signal processing of an electroretinogram measurement device. Methods include receiving, at a sensor of a circuit, light input from an electroretinogram (ERG) measurement device; generating, from the circuit, an output voltage; determining, from the output voltage, if the output voltage is within a predetermined range; and generating, at a user interface, an indication of whether the output voltage is within the predetermined range. The sensor of an example embodiment includes an inductive sensor representing a retina of a biological test subject. The sensor of an example embodiment is positioned proximate a position of an eye within a housing shaped like the biological test subject. The housing of an example embodiment is shaped like a human head.

The utility model discloses an anti-toppling medical biological test tube rack, which comprises a base, a supporting plate, a test tube jack plate and a height adjusting component, the inner surface of the supporting plate is slidably mounted on the outer surface of a supporting column, the bottom of the test tube jack plate is fixedly mounted on the top of the supporting column, and the top of the height adjusting component is fixedly mounted on the bottom of the supporting plate. The height adjusting assembly comprises a servo motor, a threaded rod, a movable sleeve and a supporting plate, the outer surface of the servo motor and the inner surface of the base are fixedly installed, the bottom end of the threaded rod and the output end of the servo motor are fixedly installed, the inner surface of the movable sleeve is in threaded connection with the outer surface of the threaded rod, and the top of the supporting plate and the bottom of the supporting disc are fixedly installed. The bottom of the supporting plate and the top end of the movable sleeve are rotationally installed. By arranging the height adjusting assembly, a worker can adjust the position of the supporting and placing disc according to the length of a test tube to be placed, so that the distance between the supporting and placing disc and the test tube insertion hole plate is at a proper height, and the practicability of the test tube rack is improved.

The invention discloses a method for repairing a probe for a biological test of a terahertz near-field system, and belongs to the technical field of terahertz near-field imaging. According to the method, aiming at the problem that the imaging quality is reduced due to the fact that a probe is polluted by water or water-containing tissues in the biological sample imaging process, the pollution condition is observed through an optical microscope, and two steps of adsorbate separation and adsorbate removal are sequentially carried out. Firstly, a small amount of neutral or weakly acidic solution is dropwise added near a needle tip for dissolution, the solution diffusion range is controlled, and contact with a substrate is avoided; after the adsorbate is separated, a large amount of solution is dropwise added for washing, suction paper is used for sucking dry from the side, and the operation is repeated to ensure that pollutants are completely removed. According to the method, mechanical external force is not needed, operation is safe, simple and reliable, the probe can be effectively repaired, the service life of the probe can be effectively prolonged, and application of a terahertz near-field system in biological imaging is promoted.

A test system includes a test container array including a plurality of test containers, and a plurality of electrodes integrated into the test container array. A test container contains a content. The test system further includes a plurality of drive-sense circuits coupled to the plurality of electrodes. When enabled, the set of drive-sense circuits transmit a set of electrode signals on the set of electrodes and generate a set of sensed signals. The test system further includes a processing module coupled to the plurality of drive-sense circuits that includes an analog reference signal generator operable to provide a set of analog reference signals to the set of drive-sense circuits, and a sensed signal processing unit operable to interpret the set of sensed signals as a set of impedance values. The set of impedance values are representative of electrical characteristics of the content.