74 results about "Biological test" patented technology

RFID-based operations management systems and methods are provided herein, particularly RFID based Kanban systems. Such system can realize increased efficiencies, improved visibility of inventory throughout the workflow and improved response to variations in demand. RFID based solutions can automatically transact consumption of Kanban inventory in real-time and trigger replenishment signals to warehouses automatically, resulting in increased Kanban inventory accuracy and lower manual efforts for replenishment and consumption posting. This approach can interface with existing operational management software (e.g. ERP systems, such as SAP) seamlessly integrating with product manufacturing workflows. Such systems are uniquely applicable to manufacture of biological testing kits, where demands fluctuate considerably in response to crises, disasters, epidemics and pandemics.

The invention discloses an experimental device for extracting exosomes, and belongs to the field of biological test equipment. The device comprises a centrifugal machine, a separation mechanism is installed in the centrifugal machine, the separation mechanism comprises a first cylinder, a second cylinder connected to the first cylinder and a third cylinder connected to the second cylinder, a primary sample is placed in the first cylinder, after primary centrifugation, the sample in the first cylinder enters the second cylinder, after secondary centrifugation, the sample in the second cylinder enters the third cylinder, and the sample in the third cylinder enters the third cylinder. The sample in the second cylinder enters the third cylinder; after the device is shut down, the centrifugal cylinder does not need to be replaced for multiple times, multiple centrifugal separation can be achieved only by transferring samples in the three cylinder bodies, and the operation efficiency is improved.

The invention concerns a remote medical-diagnosis system comprising 1) a self-sampling medical device, 2) at least one reception device, 3) at least one analysis device; and 4) a server configured to register a subject and his biological analysis request, to record the data related to the self-sampling medical device and its associated biological sample, to select at least one biological test to be realized on the self-sampling medical device, to request the at least one analysis device for performing the at least one selected biological test; to receive the data corresponding to the results of the at least one selected biological test performed by the at least one analysis device on the self-sampling medical device and produce and transmit to the subject a report comprising these results and / or eventually request a medical appointment for the subject.

The present invention discloses a series of phenylurea derivative compounds, specifically relating to the compounds as free base, or isomer, or solvate, or pharmaceutically acceptable salt forms; methods of preparing medicaments; compounds composition, and therapeutic uses thereof. The present invention has developed a series of structurally novel compounds based on histamine H3 receptor ligands, and a series of relevant biological tests have been performed on the compounds. The results of the tests all indicate that the compounds have significant H3 receptor antagonistic activity and can be used as lead compounds for the prevention or treatment of H3 receptor-related diseases.

The invention relates to the technical field of biological test waste treatment, in particular to a microbial test waste incineration device which comprises a furnace body, a motor and a transmission rack, flame throwers which are symmetrically arranged are fixedly installed on the furnace body, the output end of the motor is fixedly connected with a driving gear, two rotating rods are rotationally connected to the furnace body, and the two rotating rods are fixedly connected with the transmission rack. Driven gears are fixedly connected to the positions, corresponding to the driving gears, of the rotating rods, half gears are fixedly connected to the positions, corresponding to the interior of the furnace body, of the rotating rods, a guide block is fixedly connected to the position, corresponding to the middle of the two rotating rods, of the interior of the furnace body, and a guide groove is formed in the position, corresponding to the guide block, of the transmission rack; the garbage incinerator has the beneficial effects that due to the flexibility of the crowbar, the incineration efficiency of inspection waste can be improved, the incineration uniformity of the inspection waste can be effectively improved, and the whole incinerator is simple in structural composition, convenient to use and worthy of application and popularization.

The invention discloses a biological cell culture sampling device for a biological test, which comprises a culture bottle and a sealing cover made of a transparent material, a rotary locking mechanism and a sealing assembly are arranged between the sealing cover and a sampling port in a matched manner, and an electric push rod is fixedly arranged at the upper end of the sealing cover. The piston end of the electric push rod extends into the sealing cover and is fixedly provided with a sampling needle assembly, the side wall of the sealing cover is communicated with a vacuumizing connector and a pressure regulating air inlet valve, an efficient particle air filtering film is arranged in the pressure regulating air inlet valve, and the top of the sealing cover is provided with a suction connector used for being connected with external negative pressure suction equipment. Through cooperation of the rotary locking mechanism and the sealing assembly, reliable sealing of the sealing cover and the sampling opening of the culture bottle is achieved, vacuumizing pretreatment is combined, external air is prevented from entering the culture bottle during puncture sampling, the sterility of a culture system is guaranteed, a main sealing structure of the culture bottle does not need to be opened in the whole sampling process, and the sampling efficiency is improved. And the original stable gas environment in the culture bottle is maintained.

The invention discloses a method for predicting combined toxicity of a graphene-based material and ionic liquid. The method comprises the following steps: obtaining an adsorption coefficient through an adsorption experiment of the graphene-based material on the ionic liquid; establishing a concentration-reaction relationship of a binary mixture composed of the graphene-based material and the ionic liquid to a specific ecological species, and obtaining a mean effect concentration of the binary mixture; fitting the adsorption coefficient and the mean effect concentration through a machine learning algorithm to obtain a fitting relationship, and obtaining a quantitative structure-activity relationship model according to the fitting relationship; and inputting a to-be-detected adsorption coefficient serving as an input variable into the quantitative structure-activity relation model to obtain the combined toxicity of the binary mixture on the specific ecological species. The adsorption coefficient is used as the characteristic parameter corresponding to the toxicity data, so that the characteristic parameter is easier to obtain, and the time, manpower, material and other costs caused by biological testing when the average effect concentration is obtained are avoided; and through a machine learning method, a fitting relation is constructed, and prediction can be more efficient and accurate.

A method for evaluating a biological sample is disclosed. The method includes; (i) receiving the biological sample in a container comprising a first volume, wherein the container comprises a diluent mixture comprising a diluent and a surfactant; (ii) generating a biological testing sample in the container, wherein the biological testing sample comprises the biological sample and the diluent mixture, and wherein the biological testing sample comprises a second volume; (iii) depositing the biological testing sample from the container into a reservoir of a cartridge, wherein the reservoir is configured to receive the biological testing sample, and wherein the reservoir comprises a third volume; and (iv) analyzing the biological testing sample, wherein analyzing the biological testing sample comprises capturing one or more images of the biological testing sample from an imaging sensor of an imaging device.

The invention discloses a platinum (IV)-internal peroxy prodrug molecule and application thereof, and belongs to the technical field of biological medicine. The series of molecules are characterized by being Pt (IV) complexes modified by internal peroxide and mitochondrial targeting groups. The synthesis method sequentially comprises the following steps: carrying out oxidation and hydroxyl modification on a platinum drug, introducing a mitochondrial targeting group and a singlet oxygen carrier through an esterification reaction, and carrying out a photosensitive reaction to prepare the endoperoxide. The series of molecules are reduced into Pt (II) drugs in a tumor microenvironment, singlet oxygen is released at the same time, a mitochondrial targeting group can accurately deliver the treatment molecules, and cancers are efficiently treated. A representative molecule Oxa-EM is selected for instance analysis, the molecule generates a Pt (II) complex with anticancer activity while releasing singlet oxygen, and the singlet oxygen-Pt combined anticancer purpose is achieved. Probes DPBF and SOSG are selected to prove that the molecule releases singlet oxygen, and high performance liquid chromatography is utilized to successfully prove that the Pt (II) complex is released in a reducing environment. Further cell and animal level experiments verify that the molecule has excellent anti-tumor efficacy and safety. The invention discloses design, synthesis and biological test of platinum (IV)-peroxy prodrug molecules, and the platinum (IV)-peroxy prodrug molecules have a wide anticancer application prospect.

The present invention discloses a series of structurally novel histamine H3 receptor antagonists, specifically relating to the compounds as free base, or isomer, or solvate, or pharmaceutically acceptable salt forms; methods of preparing medicaments; compounds composition, and therapeutic uses thereof. The present invention has developed a series of structurally novel compounds based on histamine H3 receptor ligands, and a series of relevant biological tests have been performed on the compounds. The results of the tests all indicate that the compounds have significant H3 receptor antagonistic activity, and can be used as lead compounds for the prevention or treatment H3 receptor-related diseases.

The invention relates to a polyethylene glycol medicine as well as a preparation method and application thereof. Specifically, the invention relates to a compound as shown in a formula I or pharmaceutically acceptable salt thereof, an intermediate compound as shown in a formula II-XX, a method for preparing the compound, and an application of the compound in tumor resistance. Biological tests show that the compound has a remarkable inhibition effect on tumors such as breast cancer, non-small cell lung cancer, melanoma, oral squamous cell carcinoma and osteosarcoma.

The present application relates to the technical field of biological effect test equipment, and particularly relates to a spatial magnetic field generating device for biological sample test, which comprises a rack, a driving unit arranged on the rack, a magnet assembly rotating driven by the driving unit, and a control system electrically connected with the driving unit, wherein the magnet assembly comprises at least one pair of N-S pole oppositely arranged permanent magnets; the device further comprises a magnetic shielding cover arranged between the driving unit and the magnet assembly. The present application effectively suppresses the eddy current induced by the high-speed rotating permanent magnet in the metal part by introducing the magnetic shielding cover, thereby significantly reducing the operation heat of the device, solving the problem that the stability of the equipment and the environment of the biological sample are affected due to the excessively high temperature rise during long-term continuous work, and simultaneously improving the mechanical stability and the heat dissipation efficiency of the device at high speed through the high-precision dynamic balance calibration and the optimized heat dissipation hole design, so as to provide a more reliable and pure magnetic field environment for biological test.

The invention discloses an osteonecrosis early diagnosis kit based on blood detection and a biomarker, and the osteonecrosis early diagnosis kit can be used for early diagnosis of osteonecrosis through multi-omics screening based on femoral head necrosis lesion division, serological analysis of different stages of cases and cell and animal level biological tests in combination with actual detection result verification. It is determined that a group of biomolecules, namely PEBP1, ACAT1, MMP2, SOD1 and FN1 proteins, can be used for early diagnosis of osteonecrosis.

The invention discloses a biological test tube ultrasonic cleaning device and method. The biological test tube ultrasonic cleaning device comprises a base, a rack is fixedly mounted on the base, a cleaning box is fixedly mounted on the rack, a bearing frame is movably clamped in the cleaning box, a plurality of mounting grooves used for clamping test tubes are formed in the bearing frame, and a first rotating shaft is rotationally mounted on the rack; a rotating shaft is rotatably mounted on the cleaning box, a rotating rod is fixedly mounted on the rotating shaft, a cleaning brush is fixedly mounted on the rotating rod, and the rotating shaft is in transmission connection with the first rotating shaft through a gear transmission mechanism; and a second rotating shaft is rotationally mounted on the rack. The invention relates to the technical field of test tube cleaning devices, and discloses a biological test tube ultrasonic cleaning device and a cleaning method, the inner wall of a test tube in the ultrasonic cleaning process can be subjected to rotary brushing cleaning treatment, the adhesion of dirt on the inner wall of the test tube is effectively reduced, the effect after test tube cleaning is improved, and meanwhile, the test tube cleaning treatment efficiency is also improved.

The present invention discloses an optimization method for microscopic counting of free viruses in farmland soil, which belongs to the field of biological test technology. The method conducts experiments from several aspects, including instrument selection, parameter setting, soil sample usage, and key influencing factors of microscopic observation in soil virus extraction experiments, analyzes the effects of the ratio of farmland soil samples to virus extracts, different oscillating instruments and parameter settings, and anti-fluorescence quenchers and anti-fading solutions on soil virus extraction efficiency and microscopic counting in microscopic observation, and optimizes the process of microscopic counting of free viruses in farmland soil based on the analysis results. The present invention can start from the instrument selection and parameter setting, soil sample usage, and key influencing factors in microscopic observation in soil virus extraction, and propose an operating procedure suitable for fluorescent staining-microscopic counting of farmland soil viruses, which can provide a feasible technical reference for subsequent quantitative analysis of soil viruses and research on infection modes.

The invention discloses a benzoheterocycle compound, and particularly relates to structural forms such as free alkali, an isomer, a solvate and a pharmaceutically acceptable salt form of the compound. Methods for preparing such compounds; compositions comprising such compounds and therapeutic uses thereof. Based on a histamine H3 receptor ligand, a series of benzoheterocycle compounds with novel structures are developed, a series of related biological tests are performed on the compounds, and test results show that the compounds have remarkable H3 receptor antagonistic activity and can be used as lead molecules for preventing or treating diseases related to H3 receptors.

The invention discloses a method for repairing a probe for a biological test of a terahertz near-field system, and belongs to the technical field of terahertz near-field imaging. According to the method, aiming at the problem that the imaging quality is reduced due to the fact that a probe is polluted by water or water-containing tissues in the biological sample imaging process, the pollution condition is observed through an optical microscope, and two steps of adsorbate separation and adsorbate removal are sequentially carried out. Firstly, a small amount of neutral or weakly acidic solution is dropwise added near a needle tip for dissolution, the solution diffusion range is controlled, and contact with a substrate is avoided; after the adsorbate is separated, a large amount of solution is dropwise added for washing, suction paper is used for sucking dry from the side, and the operation is repeated to ensure that pollutants are completely removed. According to the method, mechanical external force is not needed, operation is safe, simple and reliable, the probe can be effectively repaired, the service life of the probe can be effectively prolonged, and application of a terahertz near-field system in biological imaging is promoted.

The invention provides an auxiliary device for extracting biological sample lipid, and relates to the technical field of biological test equipment. The device comprises a centrifugal tube and a sleeve, wherein a puncture head with an upward needle head is vertically arranged at the inner bottom of the sleeve; external threads and internal threads which are matched with each other are selectively arranged on the centrifugal tube and the sleeve respectively; when the optional external thread of the centrifugal tube is matched with the internal thread of the sleeve, a sealed air pressure space is formed between the centrifugal tube and the sleeve, and the needle tip of the puncture head starts to puncture into the optional bottom of the centrifugal tube and extracts the organic phase lipid liquid in the centrifugal tube under the action of air pressure difference. Extraction operation in a closed space is carried out through the in-tube puncture head, and the risk of personnel infection caused by exposure of pollutant molecules such as aerosol in air due to exposure of phase liquid in contact with air is avoided.

The present invention relates to methods and kits for the collection, preservation and storage of analytes of interest present in biological test samples (biofluid samples). In particular, the present invention relates to means to collect the biological test sample such that substantially all pathogen present in the biological test sample is inactivated, while preserving the analyte of interest in a format to allow subsequent analysis.

This invention discloses a biological test strip solution line coating, marking, and cutting device. The device includes: a biological test strip moving and conveying module, a biological solution line coating module, a marking line recognition inkjet module, a control processor, a line scan camera assembly, and an auxiliary material cutting module. The biological test strip moving and conveying module, by controlling the left and right movement of a reciprocating moving platform, can realize the coating, coating detection, position marking, and defect marking of the biological test strip. It can also inspect the marking lines to ensure no marking lines are missed. This device can realize automatic coating, automatic detection, automatic position marking, automatic defect marking and rejection, automatic rejection inspection, and automatic cutting according to requirements of the biological test strip, featuring automated control and a compact structure.

A set of small and medium-sized soil animal separation tools belongs to the technical field of biological test equipment. The utility model discloses a handle, handle connecting part, pick conversion head and pick component, pick conversion head is detachably installed on the end of handle through handle connecting part, and pick conversion head is provided with pick component. The utility model research and development purpose is to solve the problem that the existing tools such as tweezers are easy to cause insect body damage when separating small and medium-sized soil animals, and the operation is inconvenient, the defects that the traditional tweezers clamping method is not easy to grasp, and the insect body is easy to be damaged are overcome, through the design of replaceable pick conversion head and pick component, a set of tools can efficiently and completely separate small and medium-sized soil animals such as nematodes, mites and jumping insects with different forms and sizes, and a special tool capable of keeping the insect body complete and improving the separation efficiency is provided.

The present application relates to pyrazole derivatives as inhibitors of the PD-1 / PD-L1 interaction. The applicants have designed compounds of general formula (I) wherein R ', R2, y3, R3, R4, R5, R6 and R7 are as defined herein, which are effective in blocking PD-1 / PD-L1 interactions to restore an anti-tumor immune response in a subject and eradicate any tumors in which dormant tumor cells and PD-L1 participate in immune escape. The inventor verifies that these compounds block the PD-1 / PD-L1 interaction by performing physical and chemical tests (MST, NanoDSF) and in vitro biological tests (FRET assay, Pralomig block assay, T cell assay). These compounds have affinity (Kd) in the order of pM, which Kd is higher than the Kd of the antibody Atezumab used in clinical use, and have IC50 comparable to or higher than that observed using Atezumab. Therefore, the invention also relates to a pharmaceutical composition containing the compound and application of the pharmaceutical composition in treatment of PD-1-PD-L1 interaction related diseases (cancers, chronic inflammatory diseases, neurological diseases and chronic infections).

The invention relates to a biological test paper solution coated line production device and method. The biological test paper solution coated line production device comprises a first conveying unit, a coating unit, a position marking unit and a control unit. The device has the advantages that the position marking unit and the coating unit are integrated, an extra marking structure does not need to be independently arranged, the occupied area of the device is reduced, and the device cost is reduced; the position marking unit is used for forming the position marking signal line on the biological test paper sheet, so that the biological test paper sheet can be conveniently cut in a subsequent cutting process, the yield of the biological test paper is improved, the production efficiency is improved, and the production cost is reduced.

The utility model provides a biological detection piece with a sterile normal saline membrane capsule structure, which comprises a carrier plate, a cover piece and adding components, a plurality of adding components are movably placed on the upper side of the carrier plate, the cover piece is movably placed on the upper side of the carrier plate, the upper surface of the carrier plate is sunken downwards to form a detection piece groove, and the upper side of the carrier plate is provided with a sterile normal saline membrane capsule. Compared with the prior art, the device disclosed by the utility model has the following beneficial effects that the carrier plate and the cover plate are arranged to prevent germs in an external environment from polluting the detection chip, and the assembly is additionally arranged, so that after the membrane bag is pressed, the sterile normal saline stored in the membrane bag overcomes the tension of water, and the detection chip is prevented from being polluted by the germs in the external environment; the sterile normal saline enters the adding pipe from the connecting pipe and the arc pipe, and then the sterile normal saline is added to the edge of the detection chip from the tail end of the adding pipe, so that the purposes that the sterile normal saline can be added without opening the cover plate in the detection process, a sample is prevented from being in contact with air in the detection process, the pollution risk is greatly reduced, and the accuracy of a detection result is ensured are achieved.

The utility model relates to a kind of anti-toppling medical biological test tube rack, to solve the test tube rack of prior art usually adopts simple flat plate structure, bottom support area is smaller, when test tube is equipped with more liquid or sample with higher gravity center, it is easy to tip over due to slight shaking or external force collision, leading to experimental sample leakage, cross contamination, even cause experimental failure, increase experimental cost and time cost Problem. Rotating support foot and test tube rack piece are rotatably connected, and this flexible connection mode allows the supporting foot to be unfolded or folded according to the actual use scene and space requirement. When stable support is needed, unfold the rotating support foot, and precisely clamp and fix the rotating support foot at the unfolded position with the clamping piece to ensure the stability and reliability of the supporting foot, greatly enhancing the anti-toppling ability of the test tube rack as a whole.

An ion selective electrode (“ISE”) assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a single housing. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a cartridge that includes a sample well instead of a sample path.

The present invention relates to the technical field of thermal insulation boxes, and specifically to a transparent glass biological thermal insulation box. By setting its side panels to transparent glass, it is convenient to observe the conditions of biological test tubes inside the box. The biological test tubes are taken out by a placement rack flip control mechanism, and the biological test tubes inside the box are flipped and placed, which facilitates the removal of the biological test tubes on the bottom layer and provides convenience for their placement and subsequent overall removal. Furthermore, the biological test tubes are limited and protected by the provided auxiliary components, and are suitable for biological test tubes of different thicknesses and specifications. The working flexibility is high, and when it is necessary to take out local biological test tubes, there is no need to open the box cover body, and the operation can be performed through the operation port set in the transparent glass side panel, thereby avoiding the disconnection of the internal temperature supply, minimizing the impact as much as possible, and meeting actual use needs.

The invention relates to the technical field of sterilization equipment, in particular to a design method of an ultraviolet disinfection device and the ultraviolet disinfection device. According to the design method, an ultraviolet disinfection device model is constructed, based on a linear light source cosine emission mode and a light source superposition principle, biological testing, especially chemical indicator repeated testing and correction are adopted, and the unit length radiation power of a linear ultraviolet light source suitable for constructing the model is obtained and used for guiding design of the ultraviolet disinfection device. According to the ultraviolet disinfection device disclosed by the invention, ultraviolet rays irradiate the surface of an object or an ultraviolet-transmitting vessel from multiple directions, all-directional dead-corner-free efficient sterilization can be realized, and the ultraviolet disinfection device can be applied to equipment such as delivery windows in the biological and medical fields and can also be applied to disinfection equipment of tableware, wine sets and fresh food in the food and catering fields.

The utility model relates to a biological kit capable of preventing leakage and pollution, which belongs to the technical field of biological kits and comprises a storage box, an isolation storage mechanism is arranged in the storage box and comprises a fixed shaft fixedly mounted in the storage box, the top of the fixed shaft is rotatably connected with a knob, and the knob is connected with the isolation storage mechanism. A cover plate is fixedly installed on the outer side of the rotary knob, and the cover plate is in a sector shape. According to the biological kit capable of preventing leakage and pollution, three experimental test tubes with the same reagent can be inserted together by using the test tube seat, different experimental test tubes are mounted and fixed, and the experimental test tubes in each area can be isolated by using a partition plate, so that the storage safety and stability of different test tubes are improved; a limiting rod can be driven to open or close a hook under the action of the hook and a reset spring, so that the hook can be conveniently fixed and limited on the inner side of the fixing frame or detached, the storage box can be conveniently driven to move by using a lifting rope, the device is convenient to carry and move, and the flexibility and practicability of the device are improved.

The invention relates to the technical field of biological control, in particular to a Beauveria bassiana and attractant compounding and screening method, which comprises the following steps: collecting fruit flies with Beauveria bassiana colonies and obtaining a plurality of Beauveria bassiana strains; obtaining a biological prevention and control evaluation value of the strain through indoor biological testing, and judging whether the performance of the strain meets a preset standard or not according to the biological prevention and control evaluation value; the strains with the performance meeting the preset standard are compounded with a plurality of attractants, and a plurality of mixed agents are obtained; the spore germination rate of each mixed agent is obtained through detection, and the optimal attractant is determined; according to an attraction effect evaluation value obtained through the attraction test, whether attraction meets a preset standard or not is judged; the spore concentration is increased under the condition that the attraction does not meet the preset standard, or the reason that the attraction does not meet the preset standard is determined according to the survival bacterium carrying rate, and the attraction temperature or the attraction duration is adjusted. The biological control effect is improved.