54 results about "Biological test" patented technology

RFID-based operations management systems and methods are provided herein, particularly RFID based Kanban systems. Such system can realize increased efficiencies, improved visibility of inventory throughout the workflow and improved response to variations in demand. RFID based solutions can automatically transact consumption of Kanban inventory in real-time and trigger replenishment signals to warehouses automatically, resulting in increased Kanban inventory accuracy and lower manual efforts for replenishment and consumption posting. This approach can interface with existing operational management software (e.g. ERP systems, such as SAP) seamlessly integrating with product manufacturing workflows. Such systems are uniquely applicable to manufacture of biological testing kits, where demands fluctuate considerably in response to crises, disasters, epidemics and pandemics.

The invention discloses an experimental device for extracting exosomes, and belongs to the field of biological test equipment. The device comprises a centrifugal machine, a separation mechanism is installed in the centrifugal machine, the separation mechanism comprises a first cylinder, a second cylinder connected to the first cylinder and a third cylinder connected to the second cylinder, a primary sample is placed in the first cylinder, after primary centrifugation, the sample in the first cylinder enters the second cylinder, after secondary centrifugation, the sample in the second cylinder enters the third cylinder, and the sample in the third cylinder enters the third cylinder. The sample in the second cylinder enters the third cylinder; after the device is shut down, the centrifugal cylinder does not need to be replaced for multiple times, multiple centrifugal separation can be achieved only by transferring samples in the three cylinder bodies, and the operation efficiency is improved.

The invention concerns a remote medical-diagnosis system comprising 1) a self-sampling medical device, 2) at least one reception device, 3) at least one analysis device; and 4) a server configured to register a subject and his biological analysis request, to record the data related to the self-sampling medical device and its associated biological sample, to select at least one biological test to be realized on the self-sampling medical device, to request the at least one analysis device for performing the at least one selected biological test; to receive the data corresponding to the results of the at least one selected biological test performed by the at least one analysis device on the self-sampling medical device and produce and transmit to the subject a report comprising these results and / or eventually request a medical appointment for the subject.

The present invention discloses a series of phenylurea derivative compounds, specifically relating to the compounds as free base, or isomer, or solvate, or pharmaceutically acceptable salt forms; methods of preparing medicaments; compounds composition, and therapeutic uses thereof. The present invention has developed a series of structurally novel compounds based on histamine H3 receptor ligands, and a series of relevant biological tests have been performed on the compounds. The results of the tests all indicate that the compounds have significant H3 receptor antagonistic activity and can be used as lead compounds for the prevention or treatment of H3 receptor-related diseases.

The invention discloses a biological cell culture sampling device for a biological test, which comprises a culture bottle and a sealing cover made of a transparent material, a rotary locking mechanism and a sealing assembly are arranged between the sealing cover and a sampling port in a matched manner, and an electric push rod is fixedly arranged at the upper end of the sealing cover. The piston end of the electric push rod extends into the sealing cover and is fixedly provided with a sampling needle assembly, the side wall of the sealing cover is communicated with a vacuumizing connector and a pressure regulating air inlet valve, an efficient particle air filtering film is arranged in the pressure regulating air inlet valve, and the top of the sealing cover is provided with a suction connector used for being connected with external negative pressure suction equipment. Through cooperation of the rotary locking mechanism and the sealing assembly, reliable sealing of the sealing cover and the sampling opening of the culture bottle is achieved, vacuumizing pretreatment is combined, external air is prevented from entering the culture bottle during puncture sampling, the sterility of a culture system is guaranteed, a main sealing structure of the culture bottle does not need to be opened in the whole sampling process, and the sampling efficiency is improved. And the original stable gas environment in the culture bottle is maintained.

A method for evaluating a biological sample is disclosed. The method includes; (i) receiving the biological sample in a container comprising a first volume, wherein the container comprises a diluent mixture comprising a diluent and a surfactant; (ii) generating a biological testing sample in the container, wherein the biological testing sample comprises the biological sample and the diluent mixture, and wherein the biological testing sample comprises a second volume; (iii) depositing the biological testing sample from the container into a reservoir of a cartridge, wherein the reservoir is configured to receive the biological testing sample, and wherein the reservoir comprises a third volume; and (iv) analyzing the biological testing sample, wherein analyzing the biological testing sample comprises capturing one or more images of the biological testing sample from an imaging sensor of an imaging device.

The invention relates to a polyethylene glycol medicine as well as a preparation method and application thereof. Specifically, the invention relates to a compound as shown in a formula I or pharmaceutically acceptable salt thereof, an intermediate compound as shown in a formula II-XX, a method for preparing the compound, and an application of the compound in tumor resistance. Biological tests show that the compound has a remarkable inhibition effect on tumors such as breast cancer, non-small cell lung cancer, melanoma, oral squamous cell carcinoma and osteosarcoma.

The present application relates to the technical field of biological effect test equipment, and particularly relates to a spatial magnetic field generating device for biological sample test, which comprises a rack, a driving unit arranged on the rack, a magnet assembly rotating driven by the driving unit, and a control system electrically connected with the driving unit, wherein the magnet assembly comprises at least one pair of N-S pole oppositely arranged permanent magnets; the device further comprises a magnetic shielding cover arranged between the driving unit and the magnet assembly. The present application effectively suppresses the eddy current induced by the high-speed rotating permanent magnet in the metal part by introducing the magnetic shielding cover, thereby significantly reducing the operation heat of the device, solving the problem that the stability of the equipment and the environment of the biological sample are affected due to the excessively high temperature rise during long-term continuous work, and simultaneously improving the mechanical stability and the heat dissipation efficiency of the device at high speed through the high-precision dynamic balance calibration and the optimized heat dissipation hole design, so as to provide a more reliable and pure magnetic field environment for biological test.

The invention discloses an osteonecrosis early diagnosis kit based on blood detection and a biomarker, and the osteonecrosis early diagnosis kit can be used for early diagnosis of osteonecrosis through multi-omics screening based on femoral head necrosis lesion division, serological analysis of different stages of cases and cell and animal level biological tests in combination with actual detection result verification. It is determined that a group of biomolecules, namely PEBP1, ACAT1, MMP2, SOD1 and FN1 proteins, can be used for early diagnosis of osteonecrosis.

The invention discloses a benzoheterocycle compound, and particularly relates to structural forms such as free alkali, an isomer, a solvate and a pharmaceutically acceptable salt form of the compound. Methods for preparing such compounds; compositions comprising such compounds and therapeutic uses thereof. Based on a histamine H3 receptor ligand, a series of benzoheterocycle compounds with novel structures are developed, a series of related biological tests are performed on the compounds, and test results show that the compounds have remarkable H3 receptor antagonistic activity and can be used as lead molecules for preventing or treating diseases related to H3 receptors.

The invention discloses a method for repairing a probe for a biological test of a terahertz near-field system, and belongs to the technical field of terahertz near-field imaging. According to the method, aiming at the problem that the imaging quality is reduced due to the fact that a probe is polluted by water or water-containing tissues in the biological sample imaging process, the pollution condition is observed through an optical microscope, and two steps of adsorbate separation and adsorbate removal are sequentially carried out. Firstly, a small amount of neutral or weakly acidic solution is dropwise added near a needle tip for dissolution, the solution diffusion range is controlled, and contact with a substrate is avoided; after the adsorbate is separated, a large amount of solution is dropwise added for washing, suction paper is used for sucking dry from the side, and the operation is repeated to ensure that pollutants are completely removed. According to the method, mechanical external force is not needed, operation is safe, simple and reliable, the probe can be effectively repaired, the service life of the probe can be effectively prolonged, and application of a terahertz near-field system in biological imaging is promoted.

The invention provides an auxiliary device for extracting biological sample lipid, and relates to the technical field of biological test equipment. The device comprises a centrifugal tube and a sleeve, wherein a puncture head with an upward needle head is vertically arranged at the inner bottom of the sleeve; external threads and internal threads which are matched with each other are selectively arranged on the centrifugal tube and the sleeve respectively; when the optional external thread of the centrifugal tube is matched with the internal thread of the sleeve, a sealed air pressure space is formed between the centrifugal tube and the sleeve, and the needle tip of the puncture head starts to puncture into the optional bottom of the centrifugal tube and extracts the organic phase lipid liquid in the centrifugal tube under the action of air pressure difference. Extraction operation in a closed space is carried out through the in-tube puncture head, and the risk of personnel infection caused by exposure of pollutant molecules such as aerosol in air due to exposure of phase liquid in contact with air is avoided.

The present invention relates to methods and kits for the collection, preservation and storage of analytes of interest present in biological test samples (biofluid samples). In particular, the present invention relates to means to collect the biological test sample such that substantially all pathogen present in the biological test sample is inactivated, while preserving the analyte of interest in a format to allow subsequent analysis.

This invention discloses a biological test strip solution line coating, marking, and cutting device. The device includes: a biological test strip moving and conveying module, a biological solution line coating module, a marking line recognition inkjet module, a control processor, a line scan camera assembly, and an auxiliary material cutting module. The biological test strip moving and conveying module, by controlling the left and right movement of a reciprocating moving platform, can realize the coating, coating detection, position marking, and defect marking of the biological test strip. It can also inspect the marking lines to ensure no marking lines are missed. This device can realize automatic coating, automatic detection, automatic position marking, automatic defect marking and rejection, automatic rejection inspection, and automatic cutting according to requirements of the biological test strip, featuring automated control and a compact structure.

A set of small and medium-sized soil animal separation tools belongs to the technical field of biological test equipment. The utility model discloses a handle, handle connecting part, pick conversion head and pick component, pick conversion head is detachably installed on the end of handle through handle connecting part, and pick conversion head is provided with pick component. The utility model research and development purpose is to solve the problem that the existing tools such as tweezers are easy to cause insect body damage when separating small and medium-sized soil animals, and the operation is inconvenient, the defects that the traditional tweezers clamping method is not easy to grasp, and the insect body is easy to be damaged are overcome, through the design of replaceable pick conversion head and pick component, a set of tools can efficiently and completely separate small and medium-sized soil animals such as nematodes, mites and jumping insects with different forms and sizes, and a special tool capable of keeping the insect body complete and improving the separation efficiency is provided.

The present application relates to pyrazole derivatives as inhibitors of the PD-1 / PD-L1 interaction. The applicants have designed compounds of general formula (I) wherein R ', R2, y3, R3, R4, R5, R6 and R7 are as defined herein, which are effective in blocking PD-1 / PD-L1 interactions to restore an anti-tumor immune response in a subject and eradicate any tumors in which dormant tumor cells and PD-L1 participate in immune escape. The inventor verifies that these compounds block the PD-1 / PD-L1 interaction by performing physical and chemical tests (MST, NanoDSF) and in vitro biological tests (FRET assay, Pralomig block assay, T cell assay). These compounds have affinity (Kd) in the order of pM, which Kd is higher than the Kd of the antibody Atezumab used in clinical use, and have IC50 comparable to or higher than that observed using Atezumab. Therefore, the invention also relates to a pharmaceutical composition containing the compound and application of the pharmaceutical composition in treatment of PD-1-PD-L1 interaction related diseases (cancers, chronic inflammatory diseases, neurological diseases and chronic infections).

The utility model relates to a kind of anti-toppling medical biological test tube rack, to solve the test tube rack of prior art usually adopts simple flat plate structure, bottom support area is smaller, when test tube is equipped with more liquid or sample with higher gravity center, it is easy to tip over due to slight shaking or external force collision, leading to experimental sample leakage, cross contamination, even cause experimental failure, increase experimental cost and time cost Problem. Rotating support foot and test tube rack piece are rotatably connected, and this flexible connection mode allows the supporting foot to be unfolded or folded according to the actual use scene and space requirement. When stable support is needed, unfold the rotating support foot, and precisely clamp and fix the rotating support foot at the unfolded position with the clamping piece to ensure the stability and reliability of the supporting foot, greatly enhancing the anti-toppling ability of the test tube rack as a whole.

An ion selective electrode (“ISE”) assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a single housing. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a cartridge that includes a sample well instead of a sample path.

The invention relates to the technical field of sterilization equipment, in particular to a design method of an ultraviolet disinfection device and the ultraviolet disinfection device. According to the design method, an ultraviolet disinfection device model is constructed, based on a linear light source cosine emission mode and a light source superposition principle, biological testing, especially chemical indicator repeated testing and correction are adopted, and the unit length radiation power of a linear ultraviolet light source suitable for constructing the model is obtained and used for guiding design of the ultraviolet disinfection device. According to the ultraviolet disinfection device disclosed by the invention, ultraviolet rays irradiate the surface of an object or an ultraviolet-transmitting vessel from multiple directions, all-directional dead-corner-free efficient sterilization can be realized, and the ultraviolet disinfection device can be applied to equipment such as delivery windows in the biological and medical fields and can also be applied to disinfection equipment of tableware, wine sets and fresh food in the food and catering fields.

Provided are a biological examination device, a biological-information analyzing method, and a computer program: that make it possible, by means of a non-invasive examination, to ascertain, at a glance, up-down and front-rear two-dimensional movements of the thyroid cartilage and the hyoid bone accompanied by swallowing sounds as swallowing dynamics; and that make it possible to ascertain, at a glance, a peak position of the swallowing sounds in movement pathways of the thyroid cartilage during swallowing.　A biological examination device according to an embodiment of the present invention: identifies, from a fitting result obtained by fitting a model function that models swallowing movements to distance information based on detection data detected by a laryngeal-part displacement detection unit, an up-down movement component associated with an up-down movement of the thyroid cartilage and a front-rear movement component associated with a front-rear movement of the thyroid cartilage; and generates, on the basis of the identified up-down movement component and front-rear movement component, a two-dimensional trajectory data 901 that indicates a behavior trajectory of the thyroid cartilage in an up-down direction and a front-rear direction. In addition, identification display data are generated on the basis of the detection data from a swallowing-sound detection unit, the identification display data making it possible to determine, on the trajectory graph 901, whether the peak of the swallowing sounds is located, in a series of up-down and front-rear movement pathways of the thyroid cartilage during swallowing, in an outward path of the movement pathways, associated with upward and forward movements of the thyroid cartilage, or a return path of the movement pathways, associated with rearward and downward movements of the thyroid cartilage.

The invention belongs to the field of preparation of metal-polyphenol nano films, and provides application of a metal-polyphenol network loaded metal oxide in fungi. A metal-polyphenol nano-composite is obtained through self-assembly of gallic acid (GA) and Fecl3. 6H2O, and the metal-polyphenol nano-composite is wrapped on the surface of fungal hyphae by adopting a one-step blending method to form a nano-film. The method comprises the following steps: taking tomato early blight fungus hyphae as an object, changing the pH value of a solution, observing the wrapping condition in different time periods, and carrying out microscopic observation and biological test on the wrapped hyphae. The nano-film can provide physical protection for fungi, enhance chemical resistance, regulate growth, promote adhesion, participate in signal transduction and improve disease resistance, can improve the survival rate of fungi, enhance biological activity and improve adhesion capacity and tolerance to drugs, and has important significance in the aspects of agricultural green biological control and food fungi stability.

The invention discloses an intelligent detection method for biomedical test tubes, and belongs to the technical field of biological test tube detection.The intelligent detection method comprises the steps that image collection is conducted on different types of test tubes, and a YOLO model is used for conducting marking type training; the trained YOLO model is converted into a standardized cross-platform model format through an ONNX framework, and edge deployment reasoning is carried out; carrying out system calibration and initial reference coordinate establishment; collecting a current state image of the to-be-detected test tube box, and performing anomaly detection; performing test tube coordinate analysis and structured positioning on the image passing the anomaly detection; and the test tube space position relation obtained through detection and matching is mapped into a mechanical arm coordinate system, and the target test tube is grabbed. According to the method, the abnormal state in the test tube grabbing process can be automatically recognized and analyzed under the severe condition, the position of a grabbing target is accurately positioned, a mechanical arm is effectively guided to complete grabbing and releasing actions, and the operation reliability of a test tube carrying system is improved.

The anti-cancer agent sensitivity prediction method of the embodiment can include: receiving biological test data based on a cell experiment of a biological sample separated from an individual by a receiving unit; determining, by a processor, the sensitivity of an anti-cancer agent of the individual as a positive treatment response or a negative treatment response based on the biological test data using a sensitivity prediction model; and providing an evaluation result of the sensitivity of the anti-cancer agent of the individual; wherein the sensitivity prediction model is configured to determine the sensitivity of the anti-cancer agent based on an anti-cancer agent response factor and a cell growth factor of a cell experiment.

The invention discloses a full-automatic sample adding fluorescent quantitative PCR instrument based on biological testing, and relates to the technical field of biomedical engineering.The full-automatic sample adding fluorescent quantitative PCR instrument comprises an analysis mechanism, a processing mechanism is arranged in a shell and comprises a connecting block, and two processing tanks are arranged on the upper side of the connecting block; a flow guide shell and a connecting shell are additionally arranged on the upper side of the connecting block, a fan is additionally arranged between the interior of the flow guide shell and the interior of the connecting shell, the remaining two air inlet ends of a communicating pipe communicate with first electric valves, and two air outlets in the top of the other end of the connecting block communicate with second electric valves; by arranging the treatment mechanism, key areas in the instrument can be comprehensively covered and disinfected, meanwhile, disinfection gas left in the instrument can be treated, the disinfection effect is good, and the disinfection effect is good. Therefore, the use efficiency of the full-automatic sample adding fluorescent quantitative PCR instrument based on the biological test is improved.

The application provides a drug target interaction prediction method based on efficient fusion of multi-source data, first, multi-source data is fused or spliced by classifying drug and target multi-source data. For the original data, according to the biological characteristics of the drug or the target, several categories are divided respectively. When there are multiple networks in the category, the node feature is fused or spliced according to the characteristics of the network. Secondly, the network embedding method obtains high-quality and rich node low-dimensional feature representation. Finally, the forward unlabeled learning is used to predict the potential DTIs. According to the performance of the data, the data is classified, and the classified data is processed with different weights in the fusion process, so that the drugs and targets of different categories can be adaptively fused. Before the pharmaceutical biological test, the candidate drug target is learned by computer technology, so that the time and money cost of the biological control test are greatly reduced, and the pharmaceutical cycle is shortened.

The invention discloses a construction method and application of an anti-NMDAR encephalitis disease animal model. The construction method comprises the following steps: mixing a GluN1 (359-378) peptide fragment and mycobacterium tuberculosis (Mtb) into an incomplete Freund adjuvant to obtain an emulsified mixture, performing subcutaneous injection to two sides of the back of an anesthetized mouse, and performing intraperitoneal injection of a pertussis toxin (PTX) solution; injecting the PTX solution with the same concentration into the abdominal cavity of the mouse after 48 hours; after 14 days, repeating the first operation to carry out secondary boosted immunization on the mouse; injecting the PTX solution into the abdominal cavity again after 16 days; and after 32-35 days, biological detection is carried out to determine that modeling succeeds. According to the construction method, the period is greatly shortened, and the experiment efficiency is improved; according to the method, through an optimized immune scheme, the model success rate is high, and the phenotype is stable; the model is an active immune model and can simulate a complete disease process from autoantibody generation and immune cell infiltration to central nervous system injury.

The utility model discloses a visual analysis system for identifying and marking biological test paper film solution coating line defects, which comprises a base, a solution coating part and a visual part, a reciprocating motion part is arranged on the base, and the visual part further comprises a solution line defect marking waste ink jet assembly. The reciprocating motion component can move the sheet type biological membrane leftwards or rightwards, when the biological membrane moves rightwards, membrane scratching or metal spraying operation can be completed, then clear or fuzzy solution lines on the biological membrane are judged through the visual component, and the solution lines which do not conform to the membrane scratching and metal spraying standard are recorded as defects. Afterwards, the biological membrane moves rightwards to return to the solution line defect marking waste ink jet assembly, marking waste and mark identification of the defect position are completed, and it is confirmed that the defect is accurately marked. The device has the advantage of being compact, is an upgrade of a platform type film scratching and metal spraying instrument, realizes automatic film scratching and metal spraying, visual judgment and waste marking inspection, can replace manual waste judgment and marking processes for laboratory or small-batch processing, realizes automatic operation, and avoids the problems of long time consumption and poor precision of manual identification and marking.

The invention discloses an energy-gathering type ultrasonic crushing / cleaning device based on an acoustic superstructure. Comprising a high-power ultrasonic transducer, an acoustic superstructure groove, cooling liquid, a cylindrical groove, a power pump, a biological cell solution test tube, a cooling liquid conveying pipe and the like. When the device works, the piezoelectric plate receives electric energy and generates ultrasonic vibration, the vibration energy is transmitted to the acoustic superstructure groove through efficient propagation of the aluminum plate, the ultrasonic energy is focused in a biological test tube solution area in the groove through the groove, and a high-strength ultrasonic field is formed; meanwhile, the device can also be used for cleaning long and thin test tubes with the height-diameter ratio, narrow inner cavities and easy deposition at the bottom or adhesion to the side walls. According to the invention, the energy gathering characteristic of the acoustic superstructure is utilized, and the acoustic superstructure groove is combined with the high-power ultrasonic transducer, so that the energy density of a crushing area is remarkably improved, cells are crushed more sufficiently, cleaning procedures before and after a test are reduced, the crushing quality and the experiment efficiency are improved, and the experiment accuracy is enhanced.

A method for evaluating a biological sample is disclosed. The method includes: (i) receiving the biological sample in a container comprising a first volume, wherein the container comprises a diluent mixture comprising a diluent and a surfactant; (ii) generating a biological testing sample in the container, wherein the biological testing sample comprises the biological sample and the diluent mixture, and wherein the biological testing sample comprises a second volume; (iii) depositing the biological testing sample from the container into a reservoir of a cartridge, wherein the reservoir is configured to receive the biological testing sample, and wherein the reservoir comprises a third volume; and (iv) analyzing the biological testing sample, wherein analyzing the biological testing sample comprises capturing one or more images of the biological testing sample from an imaging sensor of an imaging device.

The utility model provides a cell culture device for biological research and development, which relates to the technical field of auxiliary devices for biological experiments and comprises a main body, a culture bin is arranged in the main body and used for placing a culture dish for culturing cells, and an upper cover for sealing the culture bin is arranged at the top of the main body. According to the device, through the pneumatic control assembly, the pressure and composition of gas in the culture bin can be accurately adjusted, cell growth environments under different physiological conditions are simulated, and the survival rate and growth efficiency of cells are improved. The design of one-way air holes ensures one-way flowing of air, unnecessary air exchange is avoided, controllability of the system is enhanced, external pollution risks are reduced, the temperature control assembly enables temperature distribution in the culture bin to be more uniform, local overheating or supercooling is avoided, and it is ensured that cells grow in a stable temperature environment. The electric heating tubes are distributed at equal intervals, temperature changes can be responded rapidly, it is guaranteed that the temperature reaches and maintains a set value rapidly, and the requirement for rapid temperature adjustment or constant-temperature experiments is met.