232 results about "Thiazine" patented technology

The invention belongs to the field of perovskite solar cells, and particularly relates to application of a bulk phase and interface synergistic passivator in a perovskite solar cell. The invention provides a bulk phase / interface synergistic passivation innovative strategy, molecules with a tricyclic sulfur-nitrogen heterocyclic ring structure are introduced as a synergistic passivator, and defect global repair of each functional layer of a device is realized. The molecular design of the structural derivative taking phenothiazine as the core has the following advantages: skeleton characteristics: a conjugated tricyclic system forms an electron transport network through pi-pi stacking, endows molecules with excellent electron delocalization ability, and effectively regulates and controls carrier kinetics; the thioether group is used for dynamically repairing an ion migration channel through oxidation-reduction activity and inhibiting formation of deep-energy-level defects; and the secondary amine group is used as a hydrogen bond donor for anchoring uncoordinated halide ions and synchronously passivating surface and grain boundary defects.

The invention provides a diaphragm and a secondary battery, and belongs to the technical field of secondary batteries, and the diaphragm comprises a base membrane and a coating. Wherein the coating is arranged on one surface, facing the positive pole piece, of the base film, and the coating comprises an electroactive material and a binder; the electroactive material comprises at least one of a quinone derivative, a phenazine derivative, an imide derivative and a phenothiazine derivative. The electroactive material in the diaphragm coating can be dissolved in the electrolyte after the environment temperature reaches the thermal safety critical temperature, and reacts with the positive and negative active materials, so that the charge state of the battery is quickly reduced, and the thermal runaway of the battery is inhibited or even avoided.

The invention relates to a 5, 9-di-tert-butyl naphtho-indolizine phenothiazine compound as well as a preparation method and medical application thereof. The compound is efficiently synthesized through Ullmann coupling and palladium-catalyzed intramolecular arylation reaction. In-vitro anti-tumor activity research shows that the compound has remarkable selective inhibitory activity on various human tumor cell lines, and particularly, the inhibitory effect on non-small cell lung cancer A549 cells (IC50 = 0.21 mu M) is improved by two orders of magnitude compared with that of cis-platinum; iC50 (half maximal inhibitory concentration) of other cell lines are as follows: 1.26 mu M of prostate cancer PC-3 cells, 6.78 mu M of liver cancer HepG2 cells, 7.99 mu M of cervical cancer Hela cells and 25.46 mu M of breast cancer MCF-7 cells. Preliminary toxicity experiments prove that the compound has the characteristic of low cytotoxicity. The compound can be used as a novel high-efficiency low-toxicity anti-tumor lead compound, and provides an important structural basis for the development of anti-cancer drugs.

The invention discloses a donor-receptor porphyrin molecular engineering-based high-sensitivity hypochlorous acid fluorescent probe and a synthesis method thereof, the structural formula of the probe is as follows: # imgabs0 #, the probe can detect hypochlorous acid (HClO) with high sensitivity, phenothiazine groups are introduced at two meso positions of porphyrin, and a donor-receptor (D-A) system is formed in molecules. The probe has rapid response performance to hypochlorous acid, sulfur atoms in phenothiazine are oxidized through hypochlorous acid, phenothiazine electrons are prevented from being transferred to porphyrin under light excitation, and therefore red fluorescence is shown, and selective detection of hypochlorous acid is achieved. After the probe reacts with hypochlorous acid, 667 nm red fluorescence is emitted under the excitation wavelength of 450 nm, the fluorescence appears obviously, and the Stokes shift is 217 nm. The reaction product has the advantages of good water solubility, high fluorescence quantum yield, large Stokes shift and the like. The probe can detect hypochlorous acid with high sensitivity, and has a huge application prospect in the technical fields of analytical chemistry, life science, environment detection, biomedical treatment and the like.

The invention discloses a ferroelectric composite fiber, a battery diaphragm, a battery piece, a lithium ion battery and a preparation method thereof, and belongs to the technical field of batteries. The ferroelectric composite fiber comprises a base membrane, and an organic ferroelectric polymer, inorganic ferroelectric nanoparticles and interface functional molecules which are loaded on the base membrane, the interface functional molecule is 1-azaphenol thiazine and / or a derivative thereof. In addition, the invention also provides a preparation method of the ferroelectric composite fiber. In addition, the invention also provides a battery diaphragm, a battery piece and a lithium ion battery. The ferroelectric composite fiber provided by the invention synchronously solves the two problems of ion transport kinetics and electrode interface stability in one-time film formation.

The invention discloses a benzothiazine phenothiazine oxide polyacrylamide copolymer phosphorescent material as well as a preparation method and application thereof, belongs to the technical field of organic phosphorescent materials, and solves the problems of harsh ORTP preparation conditions and unsatisfactory product performance in the prior art. The room-temperature phosphorescent material is obtained mainly by introducing different connecting units to the benzothiazine phenothiazine oxide and then carrying out free radical copolymerization with acrylamide, the reaction conditions are mild, the synthesis method is simple and convenient, and the materials are easy to obtain.

The invention discloses a chlorpromazine-d6 compound as well as hydrochloride, a preparation method and application thereof, and belongs to the technical field of organic synthesis and analysis detection, the chlorpromazine-d6 compound is 3-(2-chloro-10-phenothiazinyl)-N, N-bis (methyl-d3)-1-propylamine, and the preparation method comprises the following steps: taking 2-chlorophenothiazine as a raw material, adding a catalyst, and reacting at the temperature of 60-80 DEG C for 1-2 hours to obtain the chlorpromazine-d6 compound. Carrying out aza-Michael addition and reductive amination reaction to finally obtain chlorpromazine-d6; the obtained chlorpromazine-d6 is subjected to hydrochloric acid acidification, such that chlorpromazine-d6 hydrochloride is obtained; the invention provides a novel deuterated internal standard substance for analysis and detection. In addition, the invention provides a new process for preparing chlorpromazine-d6 and hydrochloride thereof with proprietary intellectual property rights, the preparation method is novel, and has the advantages of simple operation, mild reaction conditions, short process route, high efficiency, low cost, environmental protection and the like; the obtained chlorpromazine-d6 and the hydrochloride thereof have the advantages of high chemical purity, high deuteration rate, high deuterium atom stability and the like.

The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from aspirin, atorvastatin, valsartan, hydrochlorothiazide, folic acid substances and pharmaceutically acceptable auxiliary materials. The pharmaceutical composition provided by the invention has the advantages that the pharmaceutical composition provided by the invention has a multi-target synergistic prevention effect on vascular diseases, especially cerebral embolism, that is, the composition not only can reduce blood pressure, blood fat and blood homocysteine level, but also has an effect of preventing thrombosis, and reduces the risk of cerebral apoplexy. In addition, the form of the pharmaceutical composition is beneficial to improving the medication compliance of patients.

The present invention belongs to the field of medicine and relates to the use of benzothiazinone vinylidene indene compounds in the preparation of osteoclast differentiation inhibitors. The present invention uses tartrate-resistant acid phosphatase (TRAP) staining and reverse transcription real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) technology to confirm for the first time that this series of compounds can significantly inhibit RANKL-induced osteoclast differentiation and the formation of multinucleated osteoclasts, and are non-cytotoxic at concentrations of 5μM and below. Based on these findings, the benzothiazinone vinylidene indene compounds provided by the present invention can be used as candidate drug molecules for novel osteoclast differentiation inhibitors, for the prevention and / or treatment of bone metabolic diseases caused by excessive activation of osteoclasts, such as osteoporosis, periprosthetic bone dissolution, tumor metastasis bone destruction, and rheumatoid arthritis.

The invention discloses a method for efficiently preparing benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivatives with various structures by catalyzing aromatic benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide and NHC catalytic oxidation cross dehydrogenation coupling of amine, alcohol, phenol, thiol and thiophenol through carbene, and is characterized in that benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide, a nucleophilic reagent, a carbene catalyst and alkali are used as raw materials for preparing the benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivatives with various structures. The preparation method comprises the following steps: putting benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide as a raw material, an oxidant and a solvent in an air atmosphere, reacting at room temperature or under a heating condition, removing the solvent in vacuum to obtain a coarse material, and performing silica gel column chromatography purification on the coarse material to obtain the target compound benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivative. The reaction is carried out under extremely mild conditions, the substrate range is wide, and the tolerance of functional groups is good. In addition, the biological activity research of the target compound shows that the compound has the potential of being developed into an effective antifungal agent for crop protection. The compound can be used as a potential candidate drug for inhibiting phytopathogen fungi, and has good research and development value.

To provide a liquid detergent for hard surfaces which has a proper liquid color in terms of visibility and prevention of staining, while exhibiting superior liquid color stability even under storage in high-temperature conditions.SOLUTION: A liquid detergent for hard surfaces comprises (A) a non-soap anionic surfactant, (B) an aminocarboxylic acid-type chelating agent, (C) a nonionic aromatic compound represented by formula (c1), and (D) a dye selected from phthalocyanine dyes, triphenylmethane dyes, and thiazine dyes, wherein the mass ratio (A+B) / C is 2 to 400. In formula (c1), X represents an oxygen atom or an alkylene group having 1 to 4 carbon atoms, Y each independently represents a chlorine atom or a bromine atom, a, b, and c each independently represent 0 or an integer of 1 to 3, m is 0 or 1, and n is 0 or 1.SELECTED DRAWING: None

This application relates to the field of tail gas absorption technology, specifically disclosing a tail gas absorption device for phenothiazine production. The pretreatment mechanism in this application can induce sublimation of phenothiazine microcrystals in the tail gas through multiple stages, allowing the microcrystals to grow sufficiently to a collectable size before entering the collection zone. Then, a multi-stage blade collection mechanism progressively adheres and collects the grown microcrystals, achieving efficient recovery of the phenothiazine microcrystals. Simultaneously, an absorption tower is set up to absorb hydrogen sulfide from the collected tail gas with alkaline solution, and an activated carbon adsorption tower is set up to deeply purify residual hydrogen sulfide and volatile organic compounds. This forms a complete treatment chain with graded treatment and each stage performing its specific function, effectively solving the problem of blockage caused by microcrystals directly entering the absorption tower in existing technologies, while also achieving the recycling of high-value products.

The invention belongs to the technical field of medicines, and relates to an aromatic ring thiazine derivative, in particular to structural forms such as free alkali, isomeride and pharmaceutically acceptable salt form of the compound. Methods for preparing such compounds; compositions comprising such compounds and therapeutic uses thereof. Based on a histamine PI3K delta receptor ligand, a series of compounds with novel structures are developed, a series of related biological tests are carried out on the compounds, and test results show that the compounds find novel PI3K delta high-selectivity inhibitors, have the characteristics of small toxic and side effects and low bioavailability, and have broad application prospects. The pharmaceutical composition is used for developing inhaled medicines suitable for treating respiratory system diseases such as asthma and COPD, and has important clinical significance and social value.

The application relates to a synthesis method of a phenothiazine derivative, and belongs to the technical field of synthesis in organic chemistry. A diaryl iodonium salt and N-(2-mercapto phenyl)-4-methyl benzene sulfonamide are used as starting materials, and chlorpromazine and perphenazine are obtained through a plurality of steps of substitution reaction, reduction reaction, addition reaction and deprotection reaction. In the application, the reaction raw materials are easy to obtain, the yield is high, and chlorpromazine and perphenazine can be successfully obtained.

The invention discloses a quick-drying water-based ink and a preparation method thereof, and relates to the technical field of ink. The present invention first utilizes 4,6-bis(allyloxy)-n-butyl-1,3,5-thiazine-2-amine and ethylene sulfonamide to participate in the polymerization reaction of acrylic acid and butyl acrylate, and obtains a core-shell structure modified polyester emulsion with 4,6-bis(allyloxy)-n-butyl-1,3,5-thiazine-2-amine and ethylene sulfonamide as soft shells and acrylic acid and butyl acrylate as hard cores through a two-step emulsion polymerization method, thereby improving the wear resistance and durability of the ink. Then, allyl polyether is reacted with 2-(p-chlorophenyl) ethylene oxide to accelerate the drying time and improve the wear resistance of the ink; then, by reactant, bis(2-hydroxyethyl) dimethyl ammonium chloride and hydrogenated silicone oil addition reaction, a modified silicone oil leveling agent modified by epoxy-amino-polyether is formed, which has both hydrophilicity and hydrophobicity, accelerates the drying speed, and improves the wear-resistant effect.

The present invention is directed to dihydroquinazoline, -benzothiazine and -benzoxazine derivatives, advantageously for use in the prevention or treatment of neurological, psychiatric and sleep disorders and diseases in which central orexin neurotransmission is impaired or in which central and peripheral orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds for use in the prevention and / or treatment of neurological disorders and diseases. The present invention is also directed to dihydroquinazoline, -benzothiazine and -benzoxazine derivatives and the use of these compounds as medicaments.

This invention relates to a collector agent in the flotation of lead, zinc and optionally copper comprising S-alkyl-4,5-dihydro thiazole (Formula la) or N-alkyl-2- thiazolidinethione (Formula lb) or a mixture thereof wherein R1 is a C1 to C18 alkyl, C2 to C18 alkenyl, C3 to Cw cycloalkyl, C6 to C18 aryl or an alkyl ether group of the formula -(CH2)nOCH3, where n is a number from 1 to 18, such group optionally being substituted.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and particularly relates to a synthesis method of a novel polycyclic aromatic hydrocarbon derivate 2, 6-di-tert-butyl pyrene and indolizine phenothiazine compound and application of the compound in the aspect of anti-cancer drugs. The synthesis process is simple and convenient, conditions are mild, and the yield is ideal. Pharmacodynamic evaluation shows that the compound shows strong inhibitory activity on various human cancer cell lines, and the IC50 values are respectively cervical cancer Hela cells (0.17 mu M), lung cancer A549 cells (0.3 mu M), prostatic cancer PC-3 cells (0.42 mu M) and liver cancer HepG2 cells (10.79 mu M), which are respectively reduced by 109 times, 173 times, 35 times and 1.8 times compared with positive control drug cis-platinum. In addition to efficiently inhibiting cancer cells, the compound has low toxicity to normal cells, meets the basic requirements of excellent anti-cancer drugs, and shows important application value and potential in the field of research and development of novel anti-cancer drugs.

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and particularly relates to a synthesis method and anti-tumor application of a novel polycyclic aromatic hydrocarbon derivative 2, 6-di-tert-butyl phenanthroindolizino phenothiazine compound. The synthesis process is simple and convenient, and the yield is ideal. Pharmacodynamic evaluation shows that the compound has remarkable selective inhibitory activity on various human tumor cells, and the IC50 values of the compound are respectively as follows: Helaa (0.1 [mu] M), PC-3 (0.43 [mu] M), HepG2 (11.38 [mu] M), A549 (1457 [mu] M) and MCF-7 (88.25 [mu] M). Compared with cis-platinum, the compound has the advantages that the inhibiting effect on MCF-7 is weak, the inhibiting activity on other tumor cell lines is remarkably enhanced, and particularly, the IC50 value on Hela and PC-3 cells is reduced by two orders of magnitude. The compound has excellent anti-tumor activity and relatively low cytotoxicity, and has a good prospect in research and development of anti-tumor drugs.

The invention relates to the technical field of compound synthesis and pesticides, in particular to benzothiazinone pyrazole derivatives as well as a preparation method and application thereof, and the general formula of the benzothiazinone pyrazole derivatives is as shown in formula I; the derivative has effective pre-emergence and post-emergence herbicidal activity, is high in safety to crops and can be applied to preparation of herbicides; the derivative is simple in structure and preparation process, low in production cost and wide in application prospect.

The present invention provides a method of therapeutic or prophylactic treatment of microvascular brain disease in a subject comprising orally administering to the subject a reduced form of a compound comprising methylthionine (MT) wherein the administration provides the subject with 8 to 200 mg MT per day, optionally divided into two or more doses.

Provided herein are pharmaceutical compositions useful for the treatment of hypertension comprising an angiotensin II receptor blocker, a diuretic and a calcium channel blocker. These compositions are administered at a dose of 40-80% of the lowest hypertensive therapeutic dose (LHTD) per agent. The present application also relates to a composition comprising telmisartan, a thiazine-like diuretic and a calcium channel blocker, administered at a dose of from 80 to 150% of the LHTD of each agent.

In a general form, the present invention relates to a two-component mortar composition comprising a resin component (A) containing at least one radical-curable resin as a curable component, and a curing agent component (B) containing a curing agent for the radical-curable resin of the resin component (A), wherein the resin component (A) contains one or more polymerization inhibitors selected from phenolic polymerization inhibitors, phenothiazine and / or its derivatives, stable organic radicals, oximes, and pyrimidinol or pyridinol compounds substituted at the para position with respect to the hydroxyl group. In the mortar composition, the resin component (A) further contains an alkoxyamine compound (I) of the formula R-O-N(R’R”) (wherein R is an alkyl group and R’ or R” is an organic group), and this compound has an activation energy E for the homolysis of the R-O bond in the range of 100 kJ / mol to 120 kJ / mol a characterized by having the above. In another embodiment, the present invention relates to a two-component mortar composition comprising a resin component (A) containing at least one radical-curable resin as a curable component, and a curing agent component (B) containing a curing agent for the radical-curable resin of the resin component (A), wherein the resin component (A) contains one or more polymerization inhibitors selected from phenolic polymerization inhibitors, phenothiazine and / or its derivatives, stable organic radicals, oximes, and pyrimidinol or pyridinol compounds substituted at the para position with respect to the hydroxyl group, and the resin component (A) further contains an alkoxyamine compound of the following formula (II) TIFF2025518937000015.tif18150. Furthermore, the present invention relates to the use of a two-component mortar composition for chemically fixing fixing elements such as anchor threaded rods, reinforcing bars, threaded sleeves, and screws in drilled holes of building materials such as wood or mineral substrates.

This invention discloses a hole transport material, its preparation method, and its applications, relating to the field of photovoltaic materials technology. The hole transport material provided by this invention has the chemical formula shown in Formula I. The conjugated direction groups used as end groups are selected from carbazole, phenothiazine, phenoxazine, or dibenzocarbazole groups, which possess excellent carrier transport performance. Simultaneously, this invention selects α-hydroxyphosphonic acid groups as unique anchoring groups for self-assembled molecules, enabling the self-assembled molecules to form a stronger anchor with the metal oxide substrate, thereby forming a dense and uniform self-assembled layer, significantly improving the photoelectric conversion efficiency and stability of perovskite solar cells. The α-hydroxyphosphonic acid groups also have an interface passivation effect. This hole transport material, as a perovskite material layer in HTMs (Hyperoxyterephthalic Acid Transformers) cells or modules, helps improve cell efficiency and lifespan, optimize cell structure, reduce costs, and achieve large-area production and industrialization.

Disclosed are methods of synthesis and / or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

The present invention relates to sulfoxylated phenothiazine for use as a medicament. The present invention also relates to sulfoxylated phenothiazine for use in the treatment of painful sensations induced by neuropathy. The present invention also relates to a pharmaceutical composition comprising at least one sulfoxylated phenothiazine.

The application relates to the fine chemical technology field and discloses a preparation method of 2-substituted-2,3-dihydro-4 H benzothiazine-4-ketone. The specific steps are as follows: 1,2-benzisothiazolin-3-ketone and carbonyl compound are used as raw materials, hydrogen iodide and ammonium iodide are used as important additives, one-step reaction is carried out in an organic solvent, and the target product can be obtained after purification. The method is simple in operation, high in yield and has potential application value.

The present invention provides a chitin synthesis inhibitor compound-containing pesticide composition, which comprises a first effective component and a second effective component, the first effective component is a compound having a structural formula (I), the second effective component is buprofezin, lufenuron, cyromazine, diafenthiuron, diflubenzuron, chlorbenzuron, hexaflumuron or chlorfluazuron, and the weight ratio of the first effective component to the second effective component is 1-50: 1-50. The invention also provides application of the pesticide composition in prevention and control of agricultural and forestry pests, especially brown planthopper, beet armyworm or liriomyza sativae. The invention verifies that the binary composition of the inhibitor insecticide synthesized from the flufenutraniliprole and the chitin has a remarkable synergistic effect, effectively improves the control effect, reduces the dosage and expands the insecticidal spectrum. The composition disclosed by the invention has an excellent control effect on target pests such as chilo suppressalis, plutella xylostella, green peach aphid, beet armyworm, ostrinia nubilalis, thrips, flea beetle, spider mites, brown planthopper or liriomyza sativae. (I).