92 results about "Thiazine" patented technology

The invention discloses a ferroelectric composite fiber, a battery diaphragm, a battery piece, a lithium ion battery and a preparation method thereof, and belongs to the technical field of batteries. The ferroelectric composite fiber comprises a base membrane, and an organic ferroelectric polymer, inorganic ferroelectric nanoparticles and interface functional molecules which are loaded on the base membrane, the interface functional molecule is 1-azaphenol thiazine and / or a derivative thereof. In addition, the invention also provides a preparation method of the ferroelectric composite fiber. In addition, the invention also provides a battery diaphragm, a battery piece and a lithium ion battery. The ferroelectric composite fiber provided by the invention synchronously solves the two problems of ion transport kinetics and electrode interface stability in one-time film formation.

This application relates to the field of tail gas absorption technology, specifically disclosing a tail gas absorption device for phenothiazine production. The pretreatment mechanism in this application can induce sublimation of phenothiazine microcrystals in the tail gas through multiple stages, allowing the microcrystals to grow sufficiently to a collectable size before entering the collection zone. Then, a multi-stage blade collection mechanism progressively adheres and collects the grown microcrystals, achieving efficient recovery of the phenothiazine microcrystals. Simultaneously, an absorption tower is set up to absorb hydrogen sulfide from the collected tail gas with alkaline solution, and an activated carbon adsorption tower is set up to deeply purify residual hydrogen sulfide and volatile organic compounds. This forms a complete treatment chain with graded treatment and each stage performing its specific function, effectively solving the problem of blockage caused by microcrystals directly entering the absorption tower in existing technologies, while also achieving the recycling of high-value products.

The application relates to a synthesis method of a phenothiazine derivative, and belongs to the technical field of synthesis in organic chemistry. A diaryl iodonium salt and N-(2-mercapto phenyl)-4-methyl benzene sulfonamide are used as starting materials, and chlorpromazine and perphenazine are obtained through a plurality of steps of substitution reaction, reduction reaction, addition reaction and deprotection reaction. In the application, the reaction raw materials are easy to obtain, the yield is high, and chlorpromazine and perphenazine can be successfully obtained.

The present invention is directed to dihydroquinazoline, -benzothiazine and -benzoxazine derivatives, advantageously for use in the prevention or treatment of neurological, psychiatric and sleep disorders and diseases in which central orexin neurotransmission is impaired or in which central and peripheral orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds for use in the prevention and / or treatment of neurological disorders and diseases. The present invention is also directed to dihydroquinazoline, -benzothiazine and -benzoxazine derivatives and the use of these compounds as medicaments.

This invention relates to a collector agent in the flotation of lead, zinc and optionally copper comprising S-alkyl-4,5-dihydro thiazole (Formula la) or N-alkyl-2- thiazolidinethione (Formula lb) or a mixture thereof wherein R1 is a C1 to C18 alkyl, C2 to C18 alkenyl, C3 to Cw cycloalkyl, C6 to C18 aryl or an alkyl ether group of the formula -(CH2)nOCH3, where n is a number from 1 to 18, such group optionally being substituted.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

The invention relates to the technical field of compound synthesis and pesticides, in particular to benzothiazinone pyrazole derivatives as well as a preparation method and application thereof, and the general formula of the benzothiazinone pyrazole derivatives is as shown in formula I; the derivative has effective pre-emergence and post-emergence herbicidal activity, is high in safety to crops and can be applied to preparation of herbicides; the derivative is simple in structure and preparation process, low in production cost and wide in application prospect.

This invention discloses a hole transport material, its preparation method, and its applications, relating to the field of photovoltaic materials technology. The hole transport material provided by this invention has the chemical formula shown in Formula I. The conjugated direction groups used as end groups are selected from carbazole, phenothiazine, phenoxazine, or dibenzocarbazole groups, which possess excellent carrier transport performance. Simultaneously, this invention selects α-hydroxyphosphonic acid groups as unique anchoring groups for self-assembled molecules, enabling the self-assembled molecules to form a stronger anchor with the metal oxide substrate, thereby forming a dense and uniform self-assembled layer, significantly improving the photoelectric conversion efficiency and stability of perovskite solar cells. The α-hydroxyphosphonic acid groups also have an interface passivation effect. This hole transport material, as a perovskite material layer in HTMs (Hyperoxyterephthalic Acid Transformers) cells or modules, helps improve cell efficiency and lifespan, optimize cell structure, reduce costs, and achieve large-area production and industrialization.

The present invention relates to sulfoxylated phenothiazine for use as a medicament. The present invention also relates to sulfoxylated phenothiazine for use in the treatment of painful sensations induced by neuropathy. The present invention also relates to a pharmaceutical composition comprising at least one sulfoxylated phenothiazine.

The present invention provides a chitin synthesis inhibitor compound-containing pesticide composition, which comprises a first effective component and a second effective component, the first effective component is a compound having a structural formula (I), the second effective component is buprofezin, lufenuron, cyromazine, diafenthiuron, diflubenzuron, chlorbenzuron, hexaflumuron or chlorfluazuron, and the weight ratio of the first effective component to the second effective component is 1-50: 1-50. The invention also provides application of the pesticide composition in prevention and control of agricultural and forestry pests, especially brown planthopper, beet armyworm or liriomyza sativae. The invention verifies that the binary composition of the inhibitor insecticide synthesized from the flufenutraniliprole and the chitin has a remarkable synergistic effect, effectively improves the control effect, reduces the dosage and expands the insecticidal spectrum. The composition disclosed by the invention has an excellent control effect on target pests such as chilo suppressalis, plutella xylostella, green peach aphid, beet armyworm, ostrinia nubilalis, thrips, flea beetle, spider mites, brown planthopper or liriomyza sativae. (I).

The invention discloses an olmesartan medoxomil pharmaceutical co-crystal as well as a preparation, a preparation method and application thereof. The co-crystal is formed by olmesartan medoxomil and a specific co-crystal forming agent through intermolecular force. The invention also particularly provides a compound preparation containing the olmesartan medoxomil pharmaceutical co-crystal and hydrochlorothiazide. Through the eutectic technology, the invention fundamentally overcomes the inherent defects of low solubility and slow dissolution of olmesartan medoxomil as a BCS II drug. Experiments show that the preparation disclosed by the invention can realize rapid and complete drug release in vitro (the dissolution rate within 30 minutes is greater than or equal to 98%), the relative bioavailability of olmesartan in vivo can be improved by at least 180% compared with that of a reference preparation, and meanwhile, the eutectic structure ensures that the preparation has excellent chemical stability under an accelerated test condition. The invention provides an innovative solution for the development of an efficient and stable olmesartan medoxomil preparation.

The present application relates to the technical field of organic synthesis, and particularly relates to a method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone. A conventional method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone generally uses anthranilic acid as a starting material, and needs to be subjected to six-step continuous reactions to obtain the product, and the reaction time is long, the yield is low, and the operation is complicated. In view of the above problems, the present application provides a method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone, which uses 2-mercapto-N-methyl benzamide as a starting material, and is completed through one-step reaction, and the starting material and catalyst are easy to obtain, the operation is simple, the reaction is fast, the equipment requirement is low, the post-treatment is simple, and the yield is high.

The invention discloses an organic light-emitting macrocyclic material based on a boron-oxygen structure, and relates to the technical field of organic photoelectric materials. Wherein n represents the number of repetitive units, the value range of n is 3 or 4, and the Donor group is selected from one of the following groups. The invention further discloses an organic light-emitting macrocyclic material based on the boron-oxygen structure, and the organic light-emitting macrocyclic material based on the boron-oxygen structure is characterized in that a boron-oxygen multiple resonance thermal activation delayed fluorescence skeleton is covalently connected with 9, 10-dihydro-9, 9-dimethyl acridine, phenothiazine and phenoxazine groups, and a ring is formed through Buchwald-Hartwisting coupling and Friedel-Crafts alkylation reaction. According to the invention, the MR-TADF skeleton and the donor unit are selected in a modular manner to regulate the luminescence performance of the material, macrocyclic homologues with different cavity sizes are constructed, the material has the advantages of high fluorescence quantum yield, aggregation quenching resistance, high color purity and the like, and the efficiency and stability of an organic electroluminescent device can be remarkably improved.

According to the invention, structural characteristics and characteristic functions of imino polyphosphonic acid, phenoxazine or phenothiazine are combined, phenoxazine or phenothiazine, p-halonitrobenzene and vinyl phosphonate are taken as main raw materials, and a diphosphonic acid phenoxazine derivative or a diphosphonic acid phenothiazine derivative is created. The bisphosphonated phenoxazine derivative or the bisphosphonated phenothiazine derivative has the property of absorbing ultraviolet rays and the function of converting the ultraviolet rays, has good solubility in an aqueous solution and a small molecular alcohol solvent, and is suitable for a photo-electromagnetic stimulation-response hydrogel material and an organic small molecular SAM hole transport material of a perovskite solar cell.

The application relates to a lithium battery positive electrode additive resistant to floating charging and application thereof in preparation of high-energy batteries. The lithium battery positive electrode additive resistant to floating charging comprises a composite of 1-azaphenol thiazine and at least one of sodium fosinopril, lithium fosinopril or potassium fosinopril. The additive can significantly improve the interface stability of the positive electrode under high-voltage floating charging, enables the battery adopting the commercialized positive electrode to realize a high-energy density of >500 Wh / kg and a long cycle life in a conventional electrolyte, and has excellent high-rate performance, and is suitable for high-demand scenes such as satellite power sources and energy storage systems.

According to the phenothiazine functional precursor, the photosensitizer and the preparation method of the phenothiazine functional precursor, halogen or thienyl is introduced into R1 and / or R2 sites of a benzophenothiazine structure to serve as heavy atoms on the basis of structure-function relationship research of benzophenothiazine site modification, generation of strong spin-orbital coupling can be promoted, and the photosensitizer has the advantages that the photosensitizer can be used as a photosensitizer; further, intersystem crossing of the phenothiazine photosensitizer from an excited singlet state (S1) to a triplet state (T1) is promoted, so that the photosensitive effects of the phenothiazine functional precursor and the corresponding phenothiazine photosensitizer are effectively improved. Besides, after the phenothiazine photosensitizer is modified by adding a tetrazine group, controllable closing and opening of phenothiazine are realized, so that the dark toxicity of phenothiazine is effectively reduced, the targeting property and the treatment effect of the photosensitizer are improved by accessing a targeting group and a drug group into the phenothiazine photosensitizer, and the phenothiazine photosensitizer has a wide application prospect.

The invention relates to the technical field of particle raw material stirring and mixing, in particular to a compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device which comprises a plurality of treatment frames which are evenly distributed from top to bottom and provided with upward openings, discharging openings are formed in the bottoms of the treatment frames, and stirring mechanisms are installed in the treatment frames; the device adopts a manner of matching layered laying and alternate stacking, active ingredients are independently stirred and flattened, then the active ingredients and auxiliary materials are stacked layer by layer, the active ingredients are uniformly attached to the surfaces of the auxiliary materials through throwing, and multi-stage gradual dilution is carried out, so that the problem that the active ingredients are easy to disperse and non-uniform when being directly mixed can be solved, the medicine content accuracy is improved, and the medicine quality is improved. And the components of each capsule are uniform and reach the standard.

The present invention relates to a polysubstituted imidazolo[4,5-c][1,2]thiazine derivative and a use of an agent comprising same as an active agent, which is useful for infectious diseases associated with vascular inflammation caused by HMGB1 protein activity. It has been found that the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative of the present invention increases the sepsis survival rate as a result of searching for antiseptic effects through CLP-induced sepsis animal experiments. Accordingly, the agent comprising the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative or a pharmaceutically acceptable salt thereof as an active agent may be advantageously used as a therapeutic agent for infectious diseases and vascular inflammatory diseases including sepsis caused by HMGB1 protein activity.

The application discloses a kind of benzimidazole compounds and its application, belong to crop growth regulation technical field.The benzimidazole compound structural formula is;Wherein, R1 It is phenothiazine group, NH2 Or halogen;R2 It is H, CH3 Or F;R3 It is phenothiazine group, CH3, NH2, NO2 Or halogen.Benzimidazole compound is 5-nitro-2-(N-phenothiazine group)-1H-benzimidazole, 5-(N-phenothiazine group)-1H-benzimidazole or 2-bromo-5-amino-1H-benzimidazole.The application is modified to different sites of benzimidazole, designs new benzimidazole compound.The raw material of this preparation method is easy to obtain, low in cost, and operation is relatively simple.This benzimidazole compound can promote crop growth and inhibit the activity of pathogenic bacteria, and has good development prospect.

The invention provides a thiazine derivative self-assembled monomolecular layer hole transport material and a preparation method and application thereof, and belongs to the technical field of solar energy industry. The self-assembled monomolecular layer hole transport material is simple in structure, high in hole transport property, strong in interface passivation ability, high in thermal stability and suitable for large-scale application, thiazine with a rigid conjugate large plane serves as a parent nucleus, molecular accumulation can be improved, and the hole transport performance of the material can be improved; by taking a phosphate group as a tail end, single-molecule self-assembly can be realized, a perovskite interface can be passivated, the energy loss at the interface is reduced, and the battery performance is improved. When the synthesized material is used as a hole transport layer of an inverted perovskite solar cell, gt can be obtained without doping; and meanwhile, the service life of the perovskite solar cell is greatly prolonged, the stability of the perovskite solar cell is greatly improved, and industrialization of the perovskite solar cell is expected to be achieved.

The invention discloses a telmisartan and hydrochlorothiazide compound tablet which is characterized in that the telmisartan and hydrochlorothiazide compound tablet comprises a double-layer tablet A and a double-layer tablet B, and the layer A is prepared from telmisartan lipidosome, a diluent and a lubricant; and the layer B is prepared from hydrochlorothiazide, a diluent, a disintegrating agent, a lubricant and an antioxidant. The telmisartan liposome comprises lipid and telmisartan, the dosage ratio of the lipid to the telmisartan is (0.5-2.3): 1, the lipid comprises phospholipid and cholesterol, and in the lipid, the content of the cholesterol accounts for 20%-60% of the total amount of the lipid. The telmisartan liposome comprises lipid, telmisartan and a PH buffer solution, and the PH of the PH buffer solution is 5-7. According to the telmisartan and hydrochlorothiazide compound tablet prepared by the invention, the telmisartan dissolution is good, and the tablet is safe and stable.

The application discloses an Ln(IV) complex and a synthesis method and application thereof, and belongs to the technical field of chemical synthesis. The synthesis method provided by the application comprises the following steps: electrolytic oxidation of an Ln(III) precursor in a mixed system of an electron transfer medium, a supporting electrolyte and a solvent; the electron transfer medium comprises at least one of thianthrene, tris(4-bromophenyl)amine, phenoxathiin and 10-methylphenothiazine; the supporting electrolyte comprises at least one of tetrabutylammonium tetrafluoroborate and tetrabutylammonium hexafluorophosphate; the solvent comprises acetonitrile; and the Ln(III) precursor comprises at least one of Pr(III) and Tb(III). The synthesis method provided by the application has the advantages of controllable process, low cost, high efficiency, high product yield, high purity, simple purification and the like. The application further provides the Ln(IV) complex synthesized by the synthesis method and application thereof.

The present application utilizes toluene thiazide-BSA conjugate to immunize mice, and then according to the hybridoma technology, a high-purity, high-sensitivity and high-specificity anti-toluene thiazide monoclonal antibody is obtained, which can be used for developing an immune test product for detecting toluene thiazide. The anti-toluene thiazide monoclonal antibody can provide reliable laboratory diagnosis for relevant inspection and quarantine departments at the fastest speed, is suitable for screening in drug rehabilitation centers, hospitals, high-risk population census, special industries and physical examination for recruitment, and supervision of toluene thiazide drug abuse and food inspection by health and epidemic prevention departments.

Provided are a conductive material dispersion and a preparation method therefor, the conductive material dispersion comprising: a carbon-based conductive material; a first dispersant comprising a vinyl-based polymer containing an aromatic halogen atom; a second dispersant comprising a cationic compound including a thiazine structure; and a dispersion medium. Through the preparation of the conductive material dispersion comprising the first dispersant and the second dispersant together, the carbon-based conductive material is uniformly and effectively dispersed in the dispersion, so that the conductive material dispersion can exhibit a relatively low viscosity and show a small change in viscosity over time.

The application discloses a method for preparing fluorine-containing diphenylmethane compounds by using sulfur hexafluoride as a fluorination reagent, and belongs to the technical field of organic chemical synthesis. The preparation method comprises the following steps: (1) mixing a photocatalyst, a solvent and a reducing agent, and performing ultrasonic treatment to obtain solution A; mixing a reaction substrate and the solvent to obtain solution B; the photocatalyst is one or more of 4CzIPN, Ir[dF(CF3)ppy]2(dtbpy))PF6, 9-thioxanthone and 10-phenylphenothiazine; the reaction substrate is a compound with a structural formula of R1 and R2 are both H, alkoxy or halogen; (2) mixing the obtained solution A and solution B in a sulfur hexafluoride gas atmosphere, and performing reaction under blue light illumination, and the fluorine-containing diphenylmethane compounds are obtained. The method has the beneficial effects that the fluorine-containing diphenylmethane compounds are efficiently prepared by using sulfur hexafluoride as the fluorination reagent, and by selecting raw materials and catalysts with certain proportions; the reaction raw materials are cheap; the preparation process is safe, mild, has good substrate compatibility and high preparation efficiency.

The invention belongs to the technical field of medicines, and particularly relates to an aryl alkyl azole derivative as well as a preparation method and application thereof. Benzo [d] [1, 3] thiazine is used as aryl and is directly connected with 4H-1, 2, 4-triazole-4-yl through a chemical bond, and alkoxy is introduced to the C6 position of the aryl, so that the aryl alkyl azole derivative is obtained. The compound disclosed by the invention is novel in structure, shows excellent anti-convulsion activity in two epilepsy models of maximum electroshock and subcutaneous pentyltetrazole as a GABAA receptor agonist, and particularly shows an extremely high protection index, PIgt, in the subcutaneous pentyltetrazole model; and 10, the compound has the remarkable advantages of various action mechanisms, wide therapeutic window and low neurotoxicity, can be used for preparing the anti-epilepsy medicine, and is particularly suitable for treating intractable epilepsy.

1. The name of the design product: packaging box (irbesartan and hydrochlorothiazide tablets). 2. The use of the design product: the design is used for packaging box. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: perspective view. 5. The design claimed contains color.

The application discloses a kind of phenthiazine-based two-dimensional covalent organic framework materials constructed by supramolecular inclusion complex and application thereof, belong to the field of biological medicine.The phenthiazine-based two-dimensional covalent organic framework material takes 4,4',4'',4'''-(anthracene-9,10-diylbis(10H-phenthiazine-10,3,7-triyl)) tetrakisbenzaldehyde and beta-CD dithylamine inclusion complex as structural unit, and is obtained by solvothermal reaction two-dimensional crystalline porous copolymer.The application utilizes supramolecular inclusion complex and copolymerization of phenthiazine derivative and beta-CD dithylamine to obtain PTz-CD-COF with negligible biological toxicity, the material can also realize the synergistic effect of photodynamic therapy and photothermal therapy simultaneously, and cyclodextrin forms "PDT-PTT-cyclodextrin mediated synergistic" multi-component synergistic treatment system through its unique molecular recognition and inclusion effect.