160 results about "Thiazine" patented technology

The invention belongs to the field of perovskite solar cells, and particularly relates to application of a bulk phase and interface synergistic passivator in a perovskite solar cell. The invention provides a bulk phase / interface synergistic passivation innovative strategy, molecules with a tricyclic sulfur-nitrogen heterocyclic ring structure are introduced as a synergistic passivator, and defect global repair of each functional layer of a device is realized. The molecular design of the structural derivative taking phenothiazine as the core has the following advantages: skeleton characteristics: a conjugated tricyclic system forms an electron transport network through pi-pi stacking, endows molecules with excellent electron delocalization ability, and effectively regulates and controls carrier kinetics; the thioether group is used for dynamically repairing an ion migration channel through oxidation-reduction activity and inhibiting formation of deep-energy-level defects; and the secondary amine group is used as a hydrogen bond donor for anchoring uncoordinated halide ions and synchronously passivating surface and grain boundary defects.

The invention provides a diaphragm and a secondary battery, and belongs to the technical field of secondary batteries, and the diaphragm comprises a base membrane and a coating. Wherein the coating is arranged on one surface, facing the positive pole piece, of the base film, and the coating comprises an electroactive material and a binder; the electroactive material comprises at least one of a quinone derivative, a phenazine derivative, an imide derivative and a phenothiazine derivative. The electroactive material in the diaphragm coating can be dissolved in the electrolyte after the environment temperature reaches the thermal safety critical temperature, and reacts with the positive and negative active materials, so that the charge state of the battery is quickly reduced, and the thermal runaway of the battery is inhibited or even avoided.

The invention relates to a 5, 9-di-tert-butyl naphtho-indolizine phenothiazine compound as well as a preparation method and medical application thereof. The compound is efficiently synthesized through Ullmann coupling and palladium-catalyzed intramolecular arylation reaction. In-vitro anti-tumor activity research shows that the compound has remarkable selective inhibitory activity on various human tumor cell lines, and particularly, the inhibitory effect on non-small cell lung cancer A549 cells (IC50 = 0.21 mu M) is improved by two orders of magnitude compared with that of cis-platinum; iC50 (half maximal inhibitory concentration) of other cell lines are as follows: 1.26 mu M of prostate cancer PC-3 cells, 6.78 mu M of liver cancer HepG2 cells, 7.99 mu M of cervical cancer Hela cells and 25.46 mu M of breast cancer MCF-7 cells. Preliminary toxicity experiments prove that the compound has the characteristic of low cytotoxicity. The compound can be used as a novel high-efficiency low-toxicity anti-tumor lead compound, and provides an important structural basis for the development of anti-cancer drugs.

The invention discloses a ferroelectric composite fiber, a battery diaphragm, a battery piece, a lithium ion battery and a preparation method thereof, and belongs to the technical field of batteries. The ferroelectric composite fiber comprises a base membrane, and an organic ferroelectric polymer, inorganic ferroelectric nanoparticles and interface functional molecules which are loaded on the base membrane, the interface functional molecule is 1-azaphenol thiazine and / or a derivative thereof. In addition, the invention also provides a preparation method of the ferroelectric composite fiber. In addition, the invention also provides a battery diaphragm, a battery piece and a lithium ion battery. The ferroelectric composite fiber provided by the invention synchronously solves the two problems of ion transport kinetics and electrode interface stability in one-time film formation.

The invention discloses a chlorpromazine-d6 compound as well as hydrochloride, a preparation method and application thereof, and belongs to the technical field of organic synthesis and analysis detection, the chlorpromazine-d6 compound is 3-(2-chloro-10-phenothiazinyl)-N, N-bis (methyl-d3)-1-propylamine, and the preparation method comprises the following steps: taking 2-chlorophenothiazine as a raw material, adding a catalyst, and reacting at the temperature of 60-80 DEG C for 1-2 hours to obtain the chlorpromazine-d6 compound. Carrying out aza-Michael addition and reductive amination reaction to finally obtain chlorpromazine-d6; the obtained chlorpromazine-d6 is subjected to hydrochloric acid acidification, such that chlorpromazine-d6 hydrochloride is obtained; the invention provides a novel deuterated internal standard substance for analysis and detection. In addition, the invention provides a new process for preparing chlorpromazine-d6 and hydrochloride thereof with proprietary intellectual property rights, the preparation method is novel, and has the advantages of simple operation, mild reaction conditions, short process route, high efficiency, low cost, environmental protection and the like; the obtained chlorpromazine-d6 and the hydrochloride thereof have the advantages of high chemical purity, high deuteration rate, high deuterium atom stability and the like.

The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from aspirin, atorvastatin, valsartan, hydrochlorothiazide, folic acid substances and pharmaceutically acceptable auxiliary materials. The pharmaceutical composition provided by the invention has the advantages that the pharmaceutical composition provided by the invention has a multi-target synergistic prevention effect on vascular diseases, especially cerebral embolism, that is, the composition not only can reduce blood pressure, blood fat and blood homocysteine level, but also has an effect of preventing thrombosis, and reduces the risk of cerebral apoplexy. In addition, the form of the pharmaceutical composition is beneficial to improving the medication compliance of patients.

The invention discloses a method for efficiently preparing benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivatives with various structures by catalyzing aromatic benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide and NHC catalytic oxidation cross dehydrogenation coupling of amine, alcohol, phenol, thiol and thiophenol through carbene, and is characterized in that benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide, a nucleophilic reagent, a carbene catalyst and alkali are used as raw materials for preparing the benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivatives with various structures. The preparation method comprises the following steps: putting benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide as a raw material, an oxidant and a solvent in an air atmosphere, reacting at room temperature or under a heating condition, removing the solvent in vacuum to obtain a coarse material, and performing silica gel column chromatography purification on the coarse material to obtain the target compound benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivative. The reaction is carried out under extremely mild conditions, the substrate range is wide, and the tolerance of functional groups is good. In addition, the biological activity research of the target compound shows that the compound has the potential of being developed into an effective antifungal agent for crop protection. The compound can be used as a potential candidate drug for inhibiting phytopathogen fungi, and has good research and development value.

This application relates to the field of tail gas absorption technology, specifically disclosing a tail gas absorption device for phenothiazine production. The pretreatment mechanism in this application can induce sublimation of phenothiazine microcrystals in the tail gas through multiple stages, allowing the microcrystals to grow sufficiently to a collectable size before entering the collection zone. Then, a multi-stage blade collection mechanism progressively adheres and collects the grown microcrystals, achieving efficient recovery of the phenothiazine microcrystals. Simultaneously, an absorption tower is set up to absorb hydrogen sulfide from the collected tail gas with alkaline solution, and an activated carbon adsorption tower is set up to deeply purify residual hydrogen sulfide and volatile organic compounds. This forms a complete treatment chain with graded treatment and each stage performing its specific function, effectively solving the problem of blockage caused by microcrystals directly entering the absorption tower in existing technologies, while also achieving the recycling of high-value products.

The application relates to a synthesis method of a phenothiazine derivative, and belongs to the technical field of synthesis in organic chemistry. A diaryl iodonium salt and N-(2-mercapto phenyl)-4-methyl benzene sulfonamide are used as starting materials, and chlorpromazine and perphenazine are obtained through a plurality of steps of substitution reaction, reduction reaction, addition reaction and deprotection reaction. In the application, the reaction raw materials are easy to obtain, the yield is high, and chlorpromazine and perphenazine can be successfully obtained.

The present invention is directed to dihydroquinazoline, -benzothiazine and -benzoxazine derivatives, advantageously for use in the prevention or treatment of neurological, psychiatric and sleep disorders and diseases in which central orexin neurotransmission is impaired or in which central and peripheral orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds for use in the prevention and / or treatment of neurological disorders and diseases. The present invention is also directed to dihydroquinazoline, -benzothiazine and -benzoxazine derivatives and the use of these compounds as medicaments.

This invention relates to a collector agent in the flotation of lead, zinc and optionally copper comprising S-alkyl-4,5-dihydro thiazole (Formula la) or N-alkyl-2- thiazolidinethione (Formula lb) or a mixture thereof wherein R1 is a C1 to C18 alkyl, C2 to C18 alkenyl, C3 to Cw cycloalkyl, C6 to C18 aryl or an alkyl ether group of the formula -(CH2)nOCH3, where n is a number from 1 to 18, such group optionally being substituted.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and particularly relates to a synthesis method of a novel polycyclic aromatic hydrocarbon derivate 2, 6-di-tert-butyl pyrene and indolizine phenothiazine compound and application of the compound in the aspect of anti-cancer drugs. The synthesis process is simple and convenient, conditions are mild, and the yield is ideal. Pharmacodynamic evaluation shows that the compound shows strong inhibitory activity on various human cancer cell lines, and the IC50 values are respectively cervical cancer Hela cells (0.17 mu M), lung cancer A549 cells (0.3 mu M), prostatic cancer PC-3 cells (0.42 mu M) and liver cancer HepG2 cells (10.79 mu M), which are respectively reduced by 109 times, 173 times, 35 times and 1.8 times compared with positive control drug cis-platinum. In addition to efficiently inhibiting cancer cells, the compound has low toxicity to normal cells, meets the basic requirements of excellent anti-cancer drugs, and shows important application value and potential in the field of research and development of novel anti-cancer drugs.

The invention relates to the technical field of compound synthesis and pesticides, in particular to benzothiazinone pyrazole derivatives as well as a preparation method and application thereof, and the general formula of the benzothiazinone pyrazole derivatives is as shown in formula I; the derivative has effective pre-emergence and post-emergence herbicidal activity, is high in safety to crops and can be applied to preparation of herbicides; the derivative is simple in structure and preparation process, low in production cost and wide in application prospect.

The present invention provides a method of therapeutic or prophylactic treatment of microvascular brain disease in a subject comprising orally administering to the subject a reduced form of a compound comprising methylthionine (MT) wherein the administration provides the subject with 8 to 200 mg MT per day, optionally divided into two or more doses.

This invention discloses a hole transport material, its preparation method, and its applications, relating to the field of photovoltaic materials technology. The hole transport material provided by this invention has the chemical formula shown in Formula I. The conjugated direction groups used as end groups are selected from carbazole, phenothiazine, phenoxazine, or dibenzocarbazole groups, which possess excellent carrier transport performance. Simultaneously, this invention selects α-hydroxyphosphonic acid groups as unique anchoring groups for self-assembled molecules, enabling the self-assembled molecules to form a stronger anchor with the metal oxide substrate, thereby forming a dense and uniform self-assembled layer, significantly improving the photoelectric conversion efficiency and stability of perovskite solar cells. The α-hydroxyphosphonic acid groups also have an interface passivation effect. This hole transport material, as a perovskite material layer in HTMs (Hyperoxyterephthalic Acid Transformers) cells or modules, helps improve cell efficiency and lifespan, optimize cell structure, reduce costs, and achieve large-area production and industrialization.

The present invention relates to sulfoxylated phenothiazine for use as a medicament. The present invention also relates to sulfoxylated phenothiazine for use in the treatment of painful sensations induced by neuropathy. The present invention also relates to a pharmaceutical composition comprising at least one sulfoxylated phenothiazine.

The application relates to the fine chemical technology field and discloses a preparation method of 2-substituted-2,3-dihydro-4 H benzothiazine-4-ketone. The specific steps are as follows: 1,2-benzisothiazolin-3-ketone and carbonyl compound are used as raw materials, hydrogen iodide and ammonium iodide are used as important additives, one-step reaction is carried out in an organic solvent, and the target product can be obtained after purification. The method is simple in operation, high in yield and has potential application value.

The present invention provides a chitin synthesis inhibitor compound-containing pesticide composition, which comprises a first effective component and a second effective component, the first effective component is a compound having a structural formula (I), the second effective component is buprofezin, lufenuron, cyromazine, diafenthiuron, diflubenzuron, chlorbenzuron, hexaflumuron or chlorfluazuron, and the weight ratio of the first effective component to the second effective component is 1-50: 1-50. The invention also provides application of the pesticide composition in prevention and control of agricultural and forestry pests, especially brown planthopper, beet armyworm or liriomyza sativae. The invention verifies that the binary composition of the inhibitor insecticide synthesized from the flufenutraniliprole and the chitin has a remarkable synergistic effect, effectively improves the control effect, reduces the dosage and expands the insecticidal spectrum. The composition disclosed by the invention has an excellent control effect on target pests such as chilo suppressalis, plutella xylostella, green peach aphid, beet armyworm, ostrinia nubilalis, thrips, flea beetle, spider mites, brown planthopper or liriomyza sativae. (I).

The invention belongs to the field of chemical pesticides, and relates to an insecticide, in particular to benzo [e] [1, 3] thiazine-2, 4-diketone compounds, pharmaceutically acceptable salts and a preparation method thereof.The benzo [e] [1, 3] thiazine-2, 4-diketone compounds are prepared by stirring benzo [c] [1, 2] dithio-3-ketone compounds and triphenylphosphine in a solvent and then adding carbamic acid p-nitrophenyl ester compounds for a synthetic reaction. The compound is a 3, 3] thiazine-2, 4-diketone compound. Compared with a traditional synthesis method, the method has the advantages that raw materials are easy to prepare, the highest yield can reach 99%, reaction conditions are mild, operation is easy and the like, it is found through insecticidal activity screening that the synthesized benzo [e] [1, 3] thiazine-2, 4-diketone compound has good insecticidal activity, and the method has important significance on research of synthesis and application of the compound.

The application discloses a green method for synthesizing [1,2] thiazine derivative, and belongs to the technical field of green chemistry and organic synthesis. The [1,2] thiazine derivative containing alkane, alkene, halogen and heterocycle is prepared under the condition of room temperature, openness and neutrality, and a catalyst is MBr x (M is Fe 2+ , Fe 3+ , Ce 3+ , etc., and x is 2-3), and the only oxidant is H2O2. The application realizes the synthesis and preparation of [1,2] thiazine derivative with H2O2 as an oxidant for the first time, and the catalytic reaction is green and sustainable, and the use of expensive and complex catalysts is avoided. The by-product is H2O, and the problems of environmental damage and low yield caused by catalytic reactions of many other strong oxidants are solved. The application has the advantages of mild reaction condition, simple reaction process, high yield, safety, environmental protection, conformity to the green chemistry concept, wider applicability, wide development prospect and application prospect, and can be widely applied in the fields of organic synthesis, medicine, pesticide and probe, etc.

The invention discloses an olmesartan medoxomil pharmaceutical co-crystal as well as a preparation, a preparation method and application thereof. The co-crystal is formed by olmesartan medoxomil and a specific co-crystal forming agent through intermolecular force. The invention also particularly provides a compound preparation containing the olmesartan medoxomil pharmaceutical co-crystal and hydrochlorothiazide. Through the eutectic technology, the invention fundamentally overcomes the inherent defects of low solubility and slow dissolution of olmesartan medoxomil as a BCS II drug. Experiments show that the preparation disclosed by the invention can realize rapid and complete drug release in vitro (the dissolution rate within 30 minutes is greater than or equal to 98%), the relative bioavailability of olmesartan in vivo can be improved by at least 180% compared with that of a reference preparation, and meanwhile, the eutectic structure ensures that the preparation has excellent chemical stability under an accelerated test condition. The invention provides an innovative solution for the development of an efficient and stable olmesartan medoxomil preparation.

The application relates to the technical field of organic electroluminescent materials, and provides a heterocyclic compound, an organic electroluminescent device containing the same and an electronic device. The heterocyclic compound contains a mother nucleus structure of an indole-fused phenothiazine / phenoxazine, and when the compound is used as a host material or a hole adjusting layer of an organic electroluminescent device, the luminous efficiency and the service life of the device can be significantly improved.

The present application relates to the technical field of organic synthesis, and particularly relates to a method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone. A conventional method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone generally uses anthranilic acid as a starting material, and needs to be subjected to six-step continuous reactions to obtain the product, and the reaction time is long, the yield is low, and the operation is complicated. In view of the above problems, the present application provides a method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone, which uses 2-mercapto-N-methyl benzamide as a starting material, and is completed through one-step reaction, and the starting material and catalyst are easy to obtain, the operation is simple, the reaction is fast, the equipment requirement is low, the post-treatment is simple, and the yield is high.

The invention discloses an organic light-emitting macrocyclic material based on a boron-oxygen structure, and relates to the technical field of organic photoelectric materials. Wherein n represents the number of repetitive units, the value range of n is 3 or 4, and the Donor group is selected from one of the following groups. The invention further discloses an organic light-emitting macrocyclic material based on the boron-oxygen structure, and the organic light-emitting macrocyclic material based on the boron-oxygen structure is characterized in that a boron-oxygen multiple resonance thermal activation delayed fluorescence skeleton is covalently connected with 9, 10-dihydro-9, 9-dimethyl acridine, phenothiazine and phenoxazine groups, and a ring is formed through Buchwald-Hartwisting coupling and Friedel-Crafts alkylation reaction. According to the invention, the MR-TADF skeleton and the donor unit are selected in a modular manner to regulate the luminescence performance of the material, macrocyclic homologues with different cavity sizes are constructed, the material has the advantages of high fluorescence quantum yield, aggregation quenching resistance, high color purity and the like, and the efficiency and stability of an organic electroluminescent device can be remarkably improved.

According to the invention, structural characteristics and characteristic functions of imino polyphosphonic acid, phenoxazine or phenothiazine are combined, phenoxazine or phenothiazine, p-halonitrobenzene and vinyl phosphonate are taken as main raw materials, and a diphosphonic acid phenoxazine derivative or a diphosphonic acid phenothiazine derivative is created. The bisphosphonated phenoxazine derivative or the bisphosphonated phenothiazine derivative has the property of absorbing ultraviolet rays and the function of converting the ultraviolet rays, has good solubility in an aqueous solution and a small molecular alcohol solvent, and is suitable for a photo-electromagnetic stimulation-response hydrogel material and an organic small molecular SAM hole transport material of a perovskite solar cell.

The invention belongs to the technical field of organic functional materials, and particularly relates to an N-substituted phenothiazine derivative and a preparation method and application thereof.The N-substituted phenothiazine derivative comprises at least one of a unilateral compound and a bilateral compound, the structural formula of the unilateral compound is shown in the specification, and the structural formula of the bilateral compound is shown in the specification. According to the N-substituted phenothiazine derivative disclosed by the invention, the conjugation degree of a molecular skeleton is adjusted and an electron withdrawing group F atom is introduced to a peripheral benzene ring of a unit A to regulate and control overall electron distribution, so that the synthesized N-substituted phenothiazine derivative has unique photophysical properties and high selectivity, high sensitivity and high responsiveness to hypochlorite ions; the method can be widely applied to the fields of chemical sensing, environment detection, biological imaging and the like.

The application relates to a lithium battery positive electrode additive resistant to floating charging and application thereof in preparation of high-energy batteries. The lithium battery positive electrode additive resistant to floating charging comprises a composite of 1-azaphenol thiazine and at least one of sodium fosinopril, lithium fosinopril or potassium fosinopril. The additive can significantly improve the interface stability of the positive electrode under high-voltage floating charging, enables the battery adopting the commercialized positive electrode to realize a high-energy density of >500 Wh / kg and a long cycle life in a conventional electrolyte, and has excellent high-rate performance, and is suitable for high-demand scenes such as satellite power sources and energy storage systems.

According to the phenothiazine functional precursor, the photosensitizer and the preparation method of the phenothiazine functional precursor, halogen or thienyl is introduced into R1 and / or R2 sites of a benzophenothiazine structure to serve as heavy atoms on the basis of structure-function relationship research of benzophenothiazine site modification, generation of strong spin-orbital coupling can be promoted, and the photosensitizer has the advantages that the photosensitizer can be used as a photosensitizer; further, intersystem crossing of the phenothiazine photosensitizer from an excited singlet state (S1) to a triplet state (T1) is promoted, so that the photosensitive effects of the phenothiazine functional precursor and the corresponding phenothiazine photosensitizer are effectively improved. Besides, after the phenothiazine photosensitizer is modified by adding a tetrazine group, controllable closing and opening of phenothiazine are realized, so that the dark toxicity of phenothiazine is effectively reduced, the targeting property and the treatment effect of the photosensitizer are improved by accessing a targeting group and a drug group into the phenothiazine photosensitizer, and the phenothiazine photosensitizer has a wide application prospect.