111 results about "Propylamine" patented technology

The invention belongs to the technical field of automatic control, and discloses a cyclopropylamine (R)-mandelate crystallization process feedback control method, which comprises the following steps: acquiring the concentration, solvent temperature, stirring speed and pH value of cyclopropylamine (R)-mandelate in a solvent in real time, and forming a state parameter set reflecting the real-time state of a cyclopropylamine (R)-mandelate crystallization system; based on the state parameter set, deriving a solute supersaturation degree change rate, a nucleation rate and a crystal growth rate by adopting an explicit kinetic relationship to obtain a kinetic feature set of the cyclopropylamine (R)-mandelate; collecting the grain size, the shape and the crystallization uniformity of the crystal, and constructing a corresponding crystal quality prediction function in combination with the kinetic feature set of the cyclopropylamine (R)-mandelate to obtain a predicted crystal quality index; comparing the actually detected crystal morphology index with the predicted crystal quality index, and calculating to obtain a deviation value; the crystal quality of the cyclopropylamine (R)-mandelate is improved.

The invention relates to the technical field of petroleum drilling fluid loss reduction, and discloses an anti-divalent salt fluid loss agent for drilling fluid, which is prepared by the following steps: step 1, beta-cyclohexylamine and 6-chloro-1-hexene are subjected to a reaction to obtain alkenyl beta-cyclohexylamine; step 2, initiating polymerization of alkenyl beta-cyclopentadiene, a hyperbranched monomer pentaerythritol triallyl ether and 2-acrylamide-2-methylpropanesulfonic acid under the action of azobis (isobutylamidine hydrochloride), so as to obtain an intermediate A; 3, 3-dimethylamino-1-propylamine and palmitic acid are subjected to a reaction, and an intermediate 2 is obtained; 4, the intermediate 2 and benzyl chloride are subjected to a reaction, and quaternary ammonium salt modified fatty acid is obtained; and 5, stirring and mixing the intermediate A, quaternary ammonium salt modified fatty acid and coupling agent modified walnut powder to obtain the divalent salt resistant filtrate reducer for the drilling fluid. The anti-divalent salt filtrate reducer for the drilling fluid has a relatively good anti-divalent salt effect.

The present application relates to a kind of carbon dioxide mineralization method and carbon dioxide mineralization device.The carbon dioxide mineralization method includes the following steps: mixing absorption liquid and industrial solid waste at room temperature, obtain mortar;Make mortar solid-liquid separation, obtain clear liquid and thick slurry;Carbon dioxide in flue gas is absorbed by clear liquid, obtain carbon-rich absorption liquid;Carbon-rich absorption liquid and thick slurry occur mineralization reaction at 180 DEG C-220 DEG C, obtain mineralized slurry;Make mineralized slurry solid-liquid separation, obtain mineralized ash and mineralized clear liquid;Wherein, absorption liquid includes inorganic base and organic base, organic base includes monoethanolamine, diethanolamine, triethanolamine, 3-methylaminopropylamine, N-methyl diethanolamine, piperazine, diethylene triamine, triethylene tetramine, tetraethylene pentamine and 2-amino-2-methyl-1-propanolamine at least two kinds.The method greatly improves CO2 capture rate and CO2 utilization rate, and organic base consumption is less, absorption liquid regeneration energy consumption is low, and overall economy is good.

This invention discloses an amphiphilic uniform penetration inhibitor oil displacement agent, its preparation method, its application, and a method for improving oil recovery. The preparation method of the amphiphilic uniform penetration inhibitor oil displacement agent comprises the following steps: In the presence of an initiator and a solvent, sodium styrene sulfonate, acrylamide, N-ethoxymethyl-N-isobutoxymethylacrylamide, and 3-acetamino-N-ethyl-N,N-dimethylpropyl-1-amine undergo a solution polymerization reaction. The molar ratio of sodium styrene sulfonate, acrylamide, N-ethoxymethyl-N-isobutoxymethylacrylamide, and 3-acetamino-N-ethyl-N,N-dimethylpropyl-1-amine is 1:0.01–25:0.01–50:0.01–50. The solution polymerization reaction results in an amphiphilic uniform penetration inhibitor oil displacement agent with a viscosity-average molecular weight of 35 million to 40 million.

The application discloses a kind of using cobalt catalyst by unreported double migration coupling strategy, realizes migration asymmetric nitrogen hetero Nozaki-Hiyama-Kishi (aza-NHK) reaction, and the selective preparation α-chiral (E)-allyl amine starting from simple and easy to obtain ortho halogen phenyl ethylene or corresponding E / Z-alkyl bromide or its mixture belongs to the field of organic chemistry and medicinal chemistry.The application under the action of metal cobalt source, ligand, organic additive, inorganic additive etc., makes cyclic sulfonamide and ortho alkenyl substituted aryl halide or alkenyl halide react in organic solvent, to obtain a series of polysubstituted olefins with excellent regioselectivity, stereoselectivity and good yield, which can be used as active drug molecules and important synthetic intermediates.The application uses cheap transition metal cobalt as catalyst, and uses ortho alkenyl substituted aryl iodine and cyclic sulfonamide as raw material, and the reaction condition is warm, simple operation, and good functional group compatibility.

The invention belongs to the technical field of carbon dioxide capture, and discloses a mixed solvent for carbon dioxide absorption and a carbon dioxide absorption method. The invention relates to a mixed solvent for carbon dioxide absorption. The mixed solvent is prepared from 3-methylaminopropylamine, isobutylamine, pentamethyldiethylenetriamine and water, wherein the concentration of the 3-methylaminopropylamine is 1.5 mol / L, the concentration of the isobutylamine is 0.5 mol / L, and the concentration of the pentamethyldiethylenetriamine is 3 mol / L. According to the invention, MAPA with high activity of primary amine and regulation and control functions of secondary amine, IBA with a unique space structure and a high-efficiency phase-splitting agent PMDETA are compounded in a pure water phase according to a specific proportion, so that an unexpected synergistic effect is generated. The technical prejudice that the capacity must be sacrificed when the viscosity is reduced is successfully broken through. The data of the embodiment shows that compared with the closest 2M3P system, the preferable solvent has the advantages that the rich phase viscosity is greatly reduced by 60%, the absorption capacity of 4.07 mol / kg is still kept, and the desorption efficiency is remarkably improved.

The invention provides a preparation method of N, N-diisopropylethylamine based on a liquid-phase compression synthesis process, which comprises the following steps: mixing ethanol with hydrobromic acid with specified concentration, and carrying out reactive distillation treatment in the presence of a phase transfer catalyst to generate bromoethane; p-bromoethane and diisopropylamine are subjected to a liquid phase addition and compression combination reaction, and a reaction mixture is obtained; and sequentially neutralizing, distilling, condensing and filtering the reaction mixture to obtain the N, N-diisopropylethylamine, so as to solve the problems that the existing preparation method of the N, N-diisopropylethylamine is high in energy consumption, high in operation risk, large in pollutant discharge amount, low in by-product resource utilization rate, low in cost and the like. The safety is poor; the energy efficiency is low; and by-products cannot be recycled.

The invention relates to an application of propylamine bromide (C23H30BrNO3) in the treatment of sleep disorder, in particular to an application of propylamine bromide (C23H30BrNO3) in the treatment of sleep disorder. Existing sleep drugs are generally ineffective to sleep disorders related to circadian rhythm, and benzodiazepine and non-benzodiazepine hypnotics have significant side effects such as dependency, cognitive disorder and dizziness, so that long-term use of the traditional sleep drugs is limited. According to the invention, a per3 gene defect zebrafish model is used for drug screening, and a new application of a clinically used drug, namely propylamine bromide, in preparation of drugs for treating sleep disorders is provided for the first time, especially those which are insensitive to existing sedative drugs or related to circadian rhythm disorder, and have no toxic or side effects on sleep disorders. The optimal curative effect can be achieved in the indications by 20 mu M, the sleep-awakening cycle disorder caused by PER3 defects is improved, and the normal sleep-awakening cycle is recovered.

The invention discloses a glyphosate soluble concentrate and a preparation method, and the glyphosate soluble concentrate comprises the following raw material components in parts by weight: 30-40 parts of glyphosate, 10-15 parts of isopropylamine, 8-12 parts of a composite synergist, 2-3 parts of an anti-freezing agent, 0.05-0.1 part of a pH regulator, 2-3 parts of an additive, 0.1-0.5 part of a defoaming agent, 1-2 parts of a loading agent and 40-50 parts of water. Compared with the prior art, the glyphosate soluble concentrate prepared by the invention has the advantages that the propoxylated quaternary ammonium salt and the ethyoxyl alkyl phosphate are mixed according to a certain mass ratio to form the synergist, so that the pesticide effect of glyphosate is remarkably improved. Meanwhile, the aluminum pillared clay is introduced to load the glyphosate and is cooperatively used with the polydopamine-sodium alginate compound, so that the prepared glyphosate soluble concentrate has relatively high leaf deposition rate and rain wash resistance and also has excellent ultraviolet resistance.

The presently claimed invention relates to an alkaline composition for cleaning a substrate comprising i) copper or copper alloy and ii) cobalt or cobalt alloy, the composition comprising: a) at least one pH adjustor selected from diglycolamine, 4,4-diethoxy-N,N-dimethyl-1-butanamine, 3-dimethylaminopropan-1-ol, dimethylaminoethoxyethanol, N,N-dimethylisopropanolamine, ethylethanolamine, N-methyldiethanolamine, 2-(2-(methylamino)ethoxy)ethanol, 3-(methylamino)propane-1,2-diol, 2-[2-[2-(2-methoxy- ethoxy)ethoxy]ethoxy]ethylamine, 2-[2-(2-aminoethoxy)-ethoxy]-ethanol, N-butyldiethanolamine, diisopropanolamine, N-methyldiisopropanolamine, monoethanolamine, 3-dimethylamino-1,2-propandiol, 2- amino-1-butanol, 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol, prolinol, 1-methyl-2-pyrrolidinemethanol, 1-methyl-2-pyrrolidinemethanol, 1-methyl-3-pyrrolidinol, 2-amino-2-methyl-1-propanol, N,N-dimethylethanolamine, butylethanolamine, diethylethanolamine, 3-methoxypropylamine, 4-(2-hydroxyethyl)morpholine, 4-(dimethylamino)cyclohexanol, 2-amino-2-methyl-1, 3-propanediol, or diisopropylamine; b) at least one complexing agent selected from C2 to C12 hydrocarbon having at least two sulfonic acid or carboxylic acid groups; c) at least one polymeric dispersing agent having a weight average molecular weight ≥ 1000 g / mol; and d) a solvent comprising water.

The invention belongs to the technical field of electrolysis, and discloses a method for preparing p-hydroxyanisole through electrolytic oxidation of anisole. The method comprises the following steps: S1, adding anisole, an acylation reagent, an organic alkali proton trapping agent and an alkaline amine group-containing solvent into a single-chamber electrolytic bath together, starting electrification, carrying out electrolysis, and obtaining a product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the single-chamber electrolytic bath after electrolysis is finished; the organic base proton trapping agent is at least one of N, N-diisopropylethylamine, tributylamine and tripropylamine; and S2, adding a saturated sodium bicarbonate aqueous solution into the product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the step S1 to hydrolyze p-methoxytrifluoroacetic acid phenyl ester, and extracting to obtain p-hydroxyanisole. The selectivity of para-position and ortho-position products of methoxyl on anisole is regulated and controlled, so that the selectivity of p-hydroxyanisole prepared by the method is higher.

The invention discloses a synthesis method of a high-purity and high-yield antihypertensive drug, and relates to the technical field of medical chemistry. The method comprises the following steps: taking glycollic acid as an initial raw material, and carrying out acylation to obtain glycollic acid acyl chloride; carrying out Friedel-Crafts reaction on the 2-hydroxyl-5-(2-hydroxyacetyl) benzamide and salicylamide to obtain 2-hydroxyl-5-(2-hydroxyacetyl) benzamide; then, a Dess-Martin oxidizing agent is used for oxidation, and 2-hydroxy-5-(2-oxoacetyl) benzamide is obtained; the preparation method comprises the following steps: taking 2-hydroxyl-5-((4-phenylbutylamine-2-yl)-ethyl) benzamide as a raw material, then carrying out reductive amination on the 2-hydroxyl-5-(4-phenylbutylamine-2-yl)-ethyl) benzamide and 1-methyl-3-phenylpropylamine under the condition that sodium borohydride is taken as a reducing agent to obtain 2-hydroxyl-5-(1-hydroxyl-2-((4-phenylbutylamine-2-yl)-amino) ethyl) benzamide, namely And finally salifying with concentrated hydrochloric acid, crystallizing and separating to obtain the labeolol hydrochloride. The method is novel in route, convenient to operate, high in product total yield, high in purity, capable of effectively avoiding generation of dibromo impurities and suitable for large-scale production.

The present invention relates to a 3-aryloxyl-3-five-membered heteroaryl propylamine compound, and crystal form and use thereof. Specifically, the present invention provides a compound, or a pharmaceutically acceptable salt or a prodrug thereof, the compound having a structure of formula I. The compound, or pharmaceutically acceptable salt or prodrug thereof of the present invention has an excellent inhibition function for a transient receptor potential channel protein (TPR), and has a good treatment function for diseases associated with the TPR.

The invention discloses a bentazone intermediate sulfonation-chlorination two-step continuous preparation process which comprises the following steps: continuously metering and adding a solvent, chlorosulfonic acid, triethylamine, isopropylamine and a catalyst into a first-section tubular reactor, and carrying out sulfonation reaction to obtain a reaction material isopropylaminosulfonic acid; continuously introducing the reaction material isopropylamine sulfonic acid into a second section of tubular reactor, and simultaneously continuously metering and adding methyl anthranilate and phosphorus oxychloride for chlorination reaction; after the reaction is finished, quenching the reaction liquid with water, and carrying out layering and distillation treatment to obtain an intermediate o-isopropylamine sulfonamide methyl benzoate solid; and carrying out ring-closure reaction on the intermediate o-isopropylamino sulfonamido methyl benzoate solid and sodium methoxide in a methanol solution to prepare the bentazone active compound. According to the method, the defects of low bentazone product content and poor yield caused by high temperature of intermittent sulfonation and chlorination are effectively overcome, the operation time is shortened, and the productivity is improved.

The application discloses a norpinane alkyl carbazole enhanced fluorescent probe for detecting viscosity and a preparation method and application thereof. The application takes norpinone as raw material, and performs a cyclization reaction with phenylhydrazine hydrochloride to obtain a compound TC; the compound TC is subjected to N-alkylation reaction with N,N-dimethyl-3-chloropropylamine to obtain a compound TC-AP; the compound TC-AP is subjected to formylation reaction with phosphorus oxychloride to obtain a compound TC-AP-F; and the compound TC-AP-F is subjected to condensation reaction with 4-(cyanomethyl)-1-methylpyridin-1-yl iodide to obtain a fluorescent probe TC-AP-A. The probe TC-AP-A can specifically recognize viscosity, and the red fluorescence of the solution is gradually enhanced with the continuous increase of the viscosity of the system, and the minimum detection limit is 1.41 cP. The probe has the advantages of simple synthesis, good selectivity, high sensitivity, good biocompatibility, low toxicity and the like, and has a good application prospect.

A zeolite having a ferrierite framework structure produced using one or more of n-propylamine, n-butylamine, isobutylamine, and n-pentylamine as a structure directing agent.

The invention discloses a preparation method of polycation black-phase perovskite microcrystal powder, and belongs to the technical field of new energy and photoelectric materials. The method comprises the following steps: dissolving formamidine iodide (FAI), cesium iodide (CsI), lead iodide (PbI2) and an accelerant n-propylamine hydrochloride (PACl) in an alcohol solvent according to a designed molar ratio to prepare a 0.2-2 mol.L <-1 > uniform solution, and heating and stirring to form a black precipitate; and quickly filtering, washing by using an alcohol solvent to remove the residual additive, and carrying out vacuum drying to obtain the high-purity black-phase microcrystalline powder. The prepared powder has uniform Cs / FA distribution, does not contain any yellow phase, remarkably inhibits cation segregation, improves the crystallization quality and phase stability, is simple in preparation process, is easy to remove auxiliary agent residues, and can be widely applied to preparation of photoelectric devices such as high-efficiency perovskite solar cells and the like.

The application relates to the technical field of catalyst preparation, and particularly discloses a titanium-silicon molecular sieve catalyst preparation method, which comprises the following process steps: a, aging reaction: uniformly mixing raw materials, and performing aging reaction to obtain a silicon-titanium mixed solution; b, crystallization reaction: heating the silicon-titanium mixed solution to perform crystallization reaction, discharging tripropylamine gas and butanol after the reaction is completed, and obtaining a silicon-titanium sol solution; c, membrane separation: separating the silicon-titanium sol solution to obtain a clear liquid and a concentrated liquid; d, spray drying: mixing the concentrated liquid and auxiliary materials, and performing spray drying to obtain titanium-silicon molecular sieve catalyst powder; and e, calcination: calcining the titanium-silicon molecular sieve catalyst powder to obtain titanium-silicon molecular sieve catalyst products. The titanium-silicon molecular sieve catalyst preparation process has the advantages of low production cost, good stability, high safety and the like, and the titanium-silicon molecular sieve catalyst has high catalytic efficiency and good stability.

The invention belongs to the technical field of material synthesis catalysis, and particularly relates to a Cu-based defect type metal organic framework, a preparation method thereof and application of the Cu-based defect type metal organic framework in carbon dioxide catalytic conversion. The Cu-based defect type metal organic framework is prepared from triaminoguanidine hydrochloride, a pyrazole ring trinuclear cuprous complex ([Cu3 (PyCA) 3]) and imidazole-2-formaldehyde through a Schiff base condensation polymerization reaction. The Cu-based defect type metal organic framework prepared by the method can efficiently catalyze carbon dioxide and propargyl amine compounds to synthesize oxazolidinone heterocyclic compounds under normal pressure and cocatalyst-free reaction conditions, and has good recycling capability and industrial production potential.

The invention relates to a preparation method of diisopropylamine silane, which comprises the following steps: (1) reacting dichlorosilane with diisopropylamine to obtain diisopropylamine chlorosilane; and (2) carrying out a reaction on the diisopropylamine chlorosilane obtained in the step (1) and lithium hydride to obtain the diisopropylamine silane. The preparation method of diisopropylamine silane in the prior art is optimized, a complex catalyst does not need to be prepared in advance, raw materials are simple and easy to obtain, reaction steps are simple, high-temperature and high-pressure reaction conditions are avoided, the reaction conditions are mild, the obtained target product has high yield and purity, and industrial large-scale production is facilitated.

Present invention relates to a method for producing green fluorescent paint for use as a lighting for energy-efficient highway lane and park markings, characterized as comprising following production steps; adding 9,10-dibromoanthracene, CuI, Pd catalyst, diisopropylamine and toluene in a reaction flask under nitrogen atmosphere and stirring them on a magnetic stirrer, adding tetraphenylsilanacetylenyl to the mixture and performing reflux distillation by increasing the reaction temperature, after 24 hours bringing the temperature to room temperature, obtaining pure product from the mixture brought to room temperature using column chromatography, taking 0-1% by mass of the product and mixing it in resin and an aromatic solvent for 6-24 hours.

The present invention discloses an antibacterial compound of Formula 1 or pharmaceutically acceptable salt thereof:wherein X is CH, S, CH—NH2;R1 is C1-C8 alkyl, substituted alkyl, alkyl amine, substituted amine; preferably R1 is methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, methyl amine, ethylamine, propylamine, isopropyl amine, isobutylamine, N-ethylprop-2-yn-1-amine, N-isopropyl propane-1,3-diamine, N1-isopropyl ethane-1,3-diamine, 1-butyl-2-methylguanidine, N1-ethyl-N1-propylethane-1,2-diamine, cyclobutyamine, phosphate, sulphate;R2 is hydrogen, alkyl, substituted alkyl; preferably R2 is methyl, propyl, isopropyl;R3 is hydrogen, alkyl, substituted alkyl; and preferably R3 is methyl, propyl, isopropyl.The Formula 1 or pharmaceutically acceptable salt thereof is an imidazole glycerol phosphate dehydratase (IGPD) inhibitor and treats or prevents or ameliorates tuberculosis.

The application discloses a high-hardness corrosion-resistant coating material suitable for steel doors and windows and a preparation method thereof, and relates to the technical field of coating materials. In the preparation of the high-hardness corrosion-resistant coating material suitable for steel doors and windows, an inhibition and flame-retardant agent is prepared by reacting tris(aminomethyl) phosphine oxide and 8-hydroxyquinoline-5-formaldehyde; a functional epoxy monomer is prepared by sequentially reacting 2,4,6-trimethyl-1,3,5-triazine with 3-hydroxyfluorene-9-ketone and epichlorohydrin; modified graphene is prepared by reacting pre-modified graphene with 3-mercapto-1-propylamine; and the high-hardness corrosion-resistant coating material suitable for steel doors and windows is prepared by uniformly mixing epoxy resin, the functional epoxy monomer, the modified graphene, the inhibition and flame-retardant agent, triethylenetetramine, a defoaming agent and acetone. The high-hardness corrosion-resistant coating material suitable for steel doors and windows prepared by the application has excellent corrosion resistance, flame retardation and anti-aging performance.

A method of separating perfluorotripropylamine from a mixture B, the mixture B containing perfluorotripropylamine and a mixture A containing at least one selected from the group consisting of a hexafluoropropene trimer represented by C9F18, a perfluoroalkene ether, and a perfluoropolyether, where a coagulation point of the mixture A is a temperature equal to or less than a coagulation point of the perfluorotripropylamine, and separating the perfluorotripropylamine from the mixture A is carried out at a temperature equal to or less than the coagulation point of the perfluorotripropylamine.

The present application relates to a kind of method for synthesizing hexanediamine by electrochemistry of acrylonitrile, wherein electrolysis is divided into two stages, lead electrode is used in cathode in the first stage electrolysis, nanometer titanium dioxide array tube electrode is used in cathode in the second stage electrolysis, the anode used in two stage electrolysis is all DSA anode of iridium tantalum coating, electrolyte includes acrylonitrile, phosphate and quaternary ammonium base, electrolyte is injected into electrolytic cell to carry out two stage electrolysis reaction, and hexanediamine, a small amount of propylamine and a small amount of 1,3,6-hexane triamine are obtained.The process uses electrochemistry method to directly synthesize hexanediamine from acrylonitrile, process is simple, three wastes are little, and it has higher practical value.

The invention discloses an ampholytic surfactant and a preparation method thereof. The surfactant is a novel surfactant with two hydrophilic head groups and two hydrophobic tail chains and containing a rigid structure, benzoic acid and thionyl chloride are subjected to a substitution reaction to generate benzoyl chloride, then benzoyl chloride and 3-dimethylamino propylamine are subjected to a reaction to obtain N-[3-(dimethylamino) propyl] benzamide, and the N-[3-(dimethylamino) propyl] benzamide is subjected to a reaction to obtain N-[3-(dimethylamino) propyl] benzamide. Reacting N-[3-(dimethylamino) propyl] benzamide with alkyl bromide to obtain a quaternary ammonium salt intermediate product; and finally carrying out addition reaction on the quaternary ammonium salt intermediate and sodium bromoethanesulfonate to obtain the quaternary ammonium salt. According to the ampholytic surfactant prepared by the preparation method disclosed by the invention, the strong acting force of anion and cation bonds is utilized, so that the distance between hydrophilic head groups is smaller than that of a common surfactant, the critical micelle concentration of the ampholytic surfactant is lower, and the ampholytic surfactant has better emulsifying performance and cleaning capability, so that the ampholytic surfactant has better performance in the field of cleaning of IGBT chips.

The application provides a preparation method of chiral alpha-hydroxy-amidoxime ether and belongs to the technical field of organic synthesis. The preparation method of the chiral alpha-hydroxy-amidoxime ether comprises the following steps: S1, protecting the hydroxyl group of chiral alpha-hydroxy propionamide by a protecting group; S2, sequentially reacting the chiral alpha-protecting group-propionamide with an oxonium salt donor and an alkoxyamine hydrochloride to prepare chiral 1-[(E)-alkoxyimino] alpha-protecting group-prop-1-amine; and S3, removing the protecting group from the chiral 1-[(E)-alkoxyimino] alpha-protecting group-prop-1-amine to prepare a product. The application aims to overcome the core defects of a low yield, a high impurity content, a big reagent safety and environmental protection risk, a high pyridine consumption and a complicated operation of an existing process, and develop a new chiral alpha-hydroxy-amidoxime ether synthesis process with high yield, high purity, low cost, high safety and suitability for industrial amplification.

The present invention relates to a five-membered 3-aryloxy-3-heteroarylpropylamine compound, its crystalline form, and its use. Specifically, the present invention provides a compound, or a pharmaceutically acceptable salt or prodrug thereof, having the structure of Formula I. The compound, or the pharmaceutically acceptable salt or prodrug of the present invention, possesses excellent inhibitory function against the transient receptor potential (TPR) channel protein and good therapeutic function for TPR-associated diseases.

The application belongs to the field of pharmaceutical chemical industry, and particularly relates to a preparation method of a ticagrelor intermediate (1R, 2S)-2-(3, 4-difluorophenyl)cyclopropylamine, which comprises the following steps: taking compound II as raw material, and reacting with N-bromosuccinimide and sodium acetate to prepare target intermediate compound I. Compared with the prior art, the reaction has the advantages of mild reaction condition, simple operation, high safety, simple post-treatment, and safety and environmental protection. It is determined that the yield of the product prepared by the technical scheme disclosed in the application can reach more than 88%, and the purity is more than 99%.