224 results about "Propylamine" patented technology

The invention belongs to the technical field of flow battery energy storage, and discloses a multifunctional electrolyte for a zinc-bromine flow battery, a preparation method and the zinc-bromine flow battery, and the multifunctional electrolyte for the zinc-bromine flow battery comprises bromine salt, a conductive additive, water, choline bromide and N-methyl-N, N-bis (2-hydroxyethyl)-1-propylamine bromide. The molar ratio of the choline bromide to the N-methyl-N, N-bis (2-ethoxyl)-1-propylamine bromide is (0.5 to 9): 1. Based on a'synergistic 'effect and an'antagonistic' effect of a polyhydroxy structure and a choline group, effective balance between homogeneous phase performance, anti-freezing performance and the like of the electrolyte can be realized, so that the performance of a battery is improved.

The invention relates to a synthetic method of a refined dimethenamid intermediate, which comprises the following steps: adding methanol and L-alanine into a reaction flask, starting to heat, dropwise adding an esterification reagent at a certain temperature while keeping the temperature, reacting at the same temperature while keeping the temperature after dropwise adding is finished, and after the reaction is finished, carrying out post-treatment to obtain a crude product of (S)-2-amino methyl propionate; adding a solvent and a first reducing agent into the reaction flask, dropwise adding the (S)-2-methyl aminopropionate crude product and a second reducing agent at low temperature, and after dropwise adding, carrying out heat preservation reaction for a period of time at the same temperature; and raising the reaction temperature, carrying out high-temperature heat-preservation reaction for a period of time, and carrying out post-treatment to obtain the refined dimethenamid intermediate (S)-(+)-1-methoxy-2-propylamine. When the method is used for preparation, the product can be obtained only by esterifying and reducing the raw materials, the steps are simple, the raw materials are cheap and easy to obtain, and the yield is greater than 90%.

The invention belongs to the technical field of automatic control, and discloses a cyclopropylamine (R)-mandelate crystallization process feedback control method, which comprises the following steps: acquiring the concentration, solvent temperature, stirring speed and pH value of cyclopropylamine (R)-mandelate in a solvent in real time, and forming a state parameter set reflecting the real-time state of a cyclopropylamine (R)-mandelate crystallization system; based on the state parameter set, deriving a solute supersaturation degree change rate, a nucleation rate and a crystal growth rate by adopting an explicit kinetic relationship to obtain a kinetic feature set of the cyclopropylamine (R)-mandelate; collecting the grain size, the shape and the crystallization uniformity of the crystal, and constructing a corresponding crystal quality prediction function in combination with the kinetic feature set of the cyclopropylamine (R)-mandelate to obtain a predicted crystal quality index; comparing the actually detected crystal morphology index with the predicted crystal quality index, and calculating to obtain a deviation value; the crystal quality of the cyclopropylamine (R)-mandelate is improved.

The invention relates to the technical field of petroleum drilling fluid loss reduction, and discloses an anti-divalent salt fluid loss agent for drilling fluid, which is prepared by the following steps: step 1, beta-cyclohexylamine and 6-chloro-1-hexene are subjected to a reaction to obtain alkenyl beta-cyclohexylamine; step 2, initiating polymerization of alkenyl beta-cyclopentadiene, a hyperbranched monomer pentaerythritol triallyl ether and 2-acrylamide-2-methylpropanesulfonic acid under the action of azobis (isobutylamidine hydrochloride), so as to obtain an intermediate A; 3, 3-dimethylamino-1-propylamine and palmitic acid are subjected to a reaction, and an intermediate 2 is obtained; 4, the intermediate 2 and benzyl chloride are subjected to a reaction, and quaternary ammonium salt modified fatty acid is obtained; and 5, stirring and mixing the intermediate A, quaternary ammonium salt modified fatty acid and coupling agent modified walnut powder to obtain the divalent salt resistant filtrate reducer for the drilling fluid. The anti-divalent salt filtrate reducer for the drilling fluid has a relatively good anti-divalent salt effect.

The invention provides a preparation method of bis-[3-(triethoxysilyl) propyl]-disulfide. The preparation method comprises the following steps: S1, under the protection of nitrogen, dropwise adding chloropropene and trichlorosilane into a non-polar solvent, a first catalyst and tripropylamine, reacting at room temperature, taking filtrate, dropwise adding the filtrate into alcohol in a micro-reflux state, reacting, adding a sodium alkoxide / alcohol solution for neutralizing, filtering, and distilling to obtain allyltriethoxysilane; and S2, under ultraviolet light, mixing allyltriethoxysilane, mercaptopropyltriethoxysilane and benzoin dimethyl ether, reacting at room temperature for 2-3 hours, adding sulfur and a second catalyst, carrying out heating reaction, removing low boiling points, cooling, and filtering. According to the preparation method provided by the invention, bis-[3-(triethoxysilyl) propyl]-disulfide is successfully and effectively synthesized, a phase transfer catalyst does not need to be introduced for catalysis, hydrolysis of silane and treatment of saline water are reduced, the yield of single-kettle synthesis is high, and the utilization rate of equipment is high.

The present application relates to a kind of carbon dioxide mineralization method and carbon dioxide mineralization device.The carbon dioxide mineralization method includes the following steps: mixing absorption liquid and industrial solid waste at room temperature, obtain mortar;Make mortar solid-liquid separation, obtain clear liquid and thick slurry;Carbon dioxide in flue gas is absorbed by clear liquid, obtain carbon-rich absorption liquid;Carbon-rich absorption liquid and thick slurry occur mineralization reaction at 180 DEG C-220 DEG C, obtain mineralized slurry;Make mineralized slurry solid-liquid separation, obtain mineralized ash and mineralized clear liquid;Wherein, absorption liquid includes inorganic base and organic base, organic base includes monoethanolamine, diethanolamine, triethanolamine, 3-methylaminopropylamine, N-methyl diethanolamine, piperazine, diethylene triamine, triethylene tetramine, tetraethylene pentamine and 2-amino-2-methyl-1-propanolamine at least two kinds.The method greatly improves CO2 capture rate and CO2 utilization rate, and organic base consumption is less, absorption liquid regeneration energy consumption is low, and overall economy is good.

The utility model discloses a device for recovering di-n-propylamine from hydrochloride wastewater, which comprises a feeding component, a first reaction kettle, a distillation cooling device, a second reaction kettle and a separation receiving component which are sequentially connected through pipelines, and a PH (potential of hydrogen) detection device is arranged in the first reaction kettle. The utility model provides the device for recovering the di-n-propylamine from the hydrochloride wastewater, the steps of feeding, neutralizing, distilling and separating liquid are carried out in sequence to recover the di-n-propylamine from the hydrochloride wastewater, and the pH detector is arranged in the first reaction kettle, so that the use amount of liquid caustic soda can be intuitively controlled, and errors caused by manual sampling and measurement are reduced.

The invention discloses a chlorpromazine-d6 compound as well as hydrochloride, a preparation method and application thereof, and belongs to the technical field of organic synthesis and analysis detection, the chlorpromazine-d6 compound is 3-(2-chloro-10-phenothiazinyl)-N, N-bis (methyl-d3)-1-propylamine, and the preparation method comprises the following steps: taking 2-chlorophenothiazine as a raw material, adding a catalyst, and reacting at the temperature of 60-80 DEG C for 1-2 hours to obtain the chlorpromazine-d6 compound. Carrying out aza-Michael addition and reductive amination reaction to finally obtain chlorpromazine-d6; the obtained chlorpromazine-d6 is subjected to hydrochloric acid acidification, such that chlorpromazine-d6 hydrochloride is obtained; the invention provides a novel deuterated internal standard substance for analysis and detection. In addition, the invention provides a new process for preparing chlorpromazine-d6 and hydrochloride thereof with proprietary intellectual property rights, the preparation method is novel, and has the advantages of simple operation, mild reaction conditions, short process route, high efficiency, low cost, environmental protection and the like; the obtained chlorpromazine-d6 and the hydrochloride thereof have the advantages of high chemical purity, high deuteration rate, high deuterium atom stability and the like.

The invention discloses a preparation method, an intermediate and application of menochromone. The preparation method comprises the following steps: reacting 4-bromopyrrole-2-carboxylic acid with propargylamine to generate 4-bromo-N-propynyl pyrrole-2-formamide; the preparation method comprises the following steps: reacting 4-bromo-N-propinyl pyrrole-2-formamide with pinacol borane to generate a mixture; reacting the mixture with 2-(t-butyloxycarboryl amino)-5-iodo-1H-imidazole to generate (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate, and reacting the (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate with the tert-butyl carbamate; and reacting the (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate with a dioxane hydrochloride solution, so as to generate the menochromone. The invention provides a preparation method of menosin, which is short in synthetic route, simple and convenient to operate, high in product yield and suitable for industrial production.

The invention discloses a photocatalyst as well as preparation and application thereof, and belongs to the field of photocatalytic materials, and a preparation method of a porous photocatalyst based on nitrogen heterocyclic rings comprises the following steps: dispersing a parent unit (nitrogen heterocyclic ring molecules) and 1, 4-diacetylene benzene into N, N-dimethylformamide and diisopropylamine, and then quickly adding the catalyst; reacting at 60 to 180 DEG C for 60 to 180 hours; and after the reaction is finished, carrying out suction filtration, stirring and washing a filter cake with a solvent for 1-4 hours, carrying out suction filtration, repeatedly washing and carrying out suction filtration, and carrying out vacuum drying on the filter cake to obtain the nitrogen heterocyclic ring-based porous photocatalyst. The method provided by the invention has the advantages that the preparation conditions are easy to control, the method is environment-friendly, the process is simple and the operation is convenient, and the obtained material not only has high thermal stability, but also shows excellent photocatalytic performance and can be used for efficiently producing hydrogen peroxide. According to the technology, the production efficiency of hydrogen peroxide is improved, the influence on the environment is reduced, and the requirement for sustainable development of the modern chemical industry is met.

This invention discloses an amphiphilic uniform penetration inhibitor oil displacement agent, its preparation method, its application, and a method for improving oil recovery. The preparation method of the amphiphilic uniform penetration inhibitor oil displacement agent comprises the following steps: In the presence of an initiator and a solvent, sodium styrene sulfonate, acrylamide, N-ethoxymethyl-N-isobutoxymethylacrylamide, and 3-acetamino-N-ethyl-N,N-dimethylpropyl-1-amine undergo a solution polymerization reaction. The molar ratio of sodium styrene sulfonate, acrylamide, N-ethoxymethyl-N-isobutoxymethylacrylamide, and 3-acetamino-N-ethyl-N,N-dimethylpropyl-1-amine is 1:0.01–25:0.01–50:0.01–50. The solution polymerization reaction results in an amphiphilic uniform penetration inhibitor oil displacement agent with a viscosity-average molecular weight of 35 million to 40 million.

The invention provides a preparation method of (S)-(+)-1-methoxy-2-propylamine hydrochloride, which comprises the following steps: taking (S)-(+)-2-amino-1-propanol as a raw material, carrying out halogenation reaction and amino protection, then carrying out methylation reaction with methanol, and finally carrying out amino deprotection by using hydrochloric acid to obtain the product (S)-(+)-1-methoxy-2-propylamine hydrochloride. The method is suitable for industrial production.

The application discloses a kind of using cobalt catalyst by unreported double migration coupling strategy, realizes migration asymmetric nitrogen hetero Nozaki-Hiyama-Kishi (aza-NHK) reaction, and the selective preparation α-chiral (E)-allyl amine starting from simple and easy to obtain ortho halogen phenyl ethylene or corresponding E / Z-alkyl bromide or its mixture belongs to the field of organic chemistry and medicinal chemistry.The application under the action of metal cobalt source, ligand, organic additive, inorganic additive etc., makes cyclic sulfonamide and ortho alkenyl substituted aryl halide or alkenyl halide react in organic solvent, to obtain a series of polysubstituted olefins with excellent regioselectivity, stereoselectivity and good yield, which can be used as active drug molecules and important synthetic intermediates.The application uses cheap transition metal cobalt as catalyst, and uses ortho alkenyl substituted aryl iodine and cyclic sulfonamide as raw material, and the reaction condition is warm, simple operation, and good functional group compatibility.

The utility model discloses a cyclopropylamine stripping tower which comprises a stripping tower main body, a plurality of packing layers arranged at intervals are arranged in the stripping tower main body, a liquid inlet pipe is arranged above the packing layer positioned at the topmost part, the liquid inlet pipe is divided into an inlet and an outlet, the inlet is positioned outside the stripping tower, the outlet is positioned inside the stripping tower, and the liquid inlet pipe is connected with the stripping tower main body. A gas inlet pipe is arranged below the filler layer located at the bottommost part, a liquid outlet pipe is arranged at the bottom of the stripping tower, a gas outlet pipe is arranged at the top of the stripping tower, and an exhaust plate is arranged between every two filler layers; each exhaust plate comprises a rotating disc rotationally mounted in the stripping tower, a fixed disc fixedly arranged in the stripping tower and a driving part, the rotating disc is rotationally arranged on the fixed disc, and corresponding through holes are formed in the rotating disc and the fixed disc. And the size of the vent hole is changed in a rotating manner, so that the use flexibility is improved.

The invention provides a method for determining perfluorotripropylamine in consumer goods. The method comprises the following steps: sampling; adding a first reagent with a first volume into the sample, and carrying out ultrasonic treatment at a first specified temperature for a first specified time to obtain an extract liquid; adding a second volume of a second reagent into the extract liquor, carrying out ultrasonic treatment at a second specified temperature for a second specified time, and filtering to obtain a loading test solution; taking a third volume of the loading test solution, placing the loading test solution in a headspace bottle, sealing the headspace bottle, and placing the headspace bottle in a headspace-gas chromatograph-mass spectrometer for qualitative and quantitative detection analysis; wherein the analysis parameters of the headspace-gas chromatograph-mass spectrometer comprise: headspace temperature: 90 DEG C; the balance time is 30 minutes; the chromatographic column is DB-624; the flow velocity of the carrier gas is 0.6 ml / min; the column box temperature is kept at 40 DEG C for 3 minutes; raising the temperature to 240 DEG C at 25 DEG C / min, and keeping the temperature for The quantitative ion: 168.9; and qualitative ions: 68.9 and 213.9. The conditions and parameters of the method are optimized, and the perfluorotripropylamine in the consumer goods can be accurately determined.

The invention belongs to the technical field of carbon dioxide capture, and discloses a mixed solvent for carbon dioxide absorption and a carbon dioxide absorption method. The invention relates to a mixed solvent for carbon dioxide absorption. The mixed solvent is prepared from 3-methylaminopropylamine, isobutylamine, pentamethyldiethylenetriamine and water, wherein the concentration of the 3-methylaminopropylamine is 1.5 mol / L, the concentration of the isobutylamine is 0.5 mol / L, and the concentration of the pentamethyldiethylenetriamine is 3 mol / L. According to the invention, MAPA with high activity of primary amine and regulation and control functions of secondary amine, IBA with a unique space structure and a high-efficiency phase-splitting agent PMDETA are compounded in a pure water phase according to a specific proportion, so that an unexpected synergistic effect is generated. The technical prejudice that the capacity must be sacrificed when the viscosity is reduced is successfully broken through. The data of the embodiment shows that compared with the closest 2M3P system, the preferable solvent has the advantages that the rich phase viscosity is greatly reduced by 60%, the absorption capacity of 4.07 mol / kg is still kept, and the desorption efficiency is remarkably improved.

The invention provides a low-VOC (volatile organic compound) precise instrument cleaning agent. The low-VOC precise instrument cleaning agent is prepared from trans-dichloroethylene, isopropanol, a fluorocarbon solvent, a dicarbonyl compound and organic amine, the content of the trans-dichloroethylene is not less than 50% by mass, the content of the isopropanol is not less than 1% by mass, the content of the fluorocarbon solvent is not less than 30% by mass, the content of the dicarbonyl compound is not less than 2% by mass, and the content of the organic amine is not less than 1% by mass; wherein the fluorocarbon solvent is one or more of methyl (ethyl) nonafluorobutyl ether, methyl (ethyl) nonafluoroisobutyl ether, 3-methoxy-2-trifluoromethyl octafluorobutane, perfluorotriethylamine, perfluorotripropylamine, perfluorotributylamine, a perfluoropropylene oligomer (dimer or trimer) and perfluorohexanone. The precise cleaning agent prepared through the scheme has good cleaning capacity for scaling powder and metal salt, scaling powder residues on the inner surface and the outer surface of a complex circuit are effectively removed, and an important guarantee is provided for stable production of electronic products.

The invention provides a preparation method of N, N-diisopropylethylamine based on a liquid-phase compression synthesis process, which comprises the following steps: mixing ethanol with hydrobromic acid with specified concentration, and carrying out reactive distillation treatment in the presence of a phase transfer catalyst to generate bromoethane; p-bromoethane and diisopropylamine are subjected to a liquid phase addition and compression combination reaction, and a reaction mixture is obtained; and sequentially neutralizing, distilling, condensing and filtering the reaction mixture to obtain the N, N-diisopropylethylamine, so as to solve the problems that the existing preparation method of the N, N-diisopropylethylamine is high in energy consumption, high in operation risk, large in pollutant discharge amount, low in by-product resource utilization rate, low in cost and the like. The safety is poor; the energy efficiency is low; and by-products cannot be recycled.

The invention relates to an application of propylamine bromide (C23H30BrNO3) in the treatment of sleep disorder, in particular to an application of propylamine bromide (C23H30BrNO3) in the treatment of sleep disorder. Existing sleep drugs are generally ineffective to sleep disorders related to circadian rhythm, and benzodiazepine and non-benzodiazepine hypnotics have significant side effects such as dependency, cognitive disorder and dizziness, so that long-term use of the traditional sleep drugs is limited. According to the invention, a per3 gene defect zebrafish model is used for drug screening, and a new application of a clinically used drug, namely propylamine bromide, in preparation of drugs for treating sleep disorders is provided for the first time, especially those which are insensitive to existing sedative drugs or related to circadian rhythm disorder, and have no toxic or side effects on sleep disorders. The optimal curative effect can be achieved in the indications by 20 mu M, the sleep-awakening cycle disorder caused by PER3 defects is improved, and the normal sleep-awakening cycle is recovered.

The present invention provides a method for preparing spermidine, which relates to the technical field of organic synthesis. The method for preparing spermidine comprises: condensing 3-chloropropylamine hydrochloride and triphenylmethane to obtain 3-chloro-N-tritylpropylamine; condensing 3-chloro-N-tritylpropylamine and 1,4-butanediamine to obtain N 1 ‑(3‑(tritylamino)propyl)butane‑1,4‑diamine; N 1 The trityl group is removed from 1,4-(3-(tritylamino)propyl)butane to obtain spermidine hydrochloride; and spermidine hydrochloride is liberated in the presence of a base to obtain spermidine. The preparation method of the present invention can achieve a high yield and purity in a relatively short reaction period, avoids the problems of a high proportion of by-products, high purification difficulty, and residual solvent, improves the reaction efficiency, and has mild reaction conditions, simple production equipment, and is more energy-saving and environmentally friendly while being convenient for industrialized amplification production.

The invention discloses a glyphosate soluble concentrate and a preparation method, and the glyphosate soluble concentrate comprises the following raw material components in parts by weight: 30-40 parts of glyphosate, 10-15 parts of isopropylamine, 8-12 parts of a composite synergist, 2-3 parts of an anti-freezing agent, 0.05-0.1 part of a pH regulator, 2-3 parts of an additive, 0.1-0.5 part of a defoaming agent, 1-2 parts of a loading agent and 40-50 parts of water. Compared with the prior art, the glyphosate soluble concentrate prepared by the invention has the advantages that the propoxylated quaternary ammonium salt and the ethyoxyl alkyl phosphate are mixed according to a certain mass ratio to form the synergist, so that the pesticide effect of glyphosate is remarkably improved. Meanwhile, the aluminum pillared clay is introduced to load the glyphosate and is cooperatively used with the polydopamine-sodium alginate compound, so that the prepared glyphosate soluble concentrate has relatively high leaf deposition rate and rain wash resistance and also has excellent ultraviolet resistance.

To provide a separation method capable of efficiently separating perfluorotripropylamine from a mixture that comprises the perfluorotripropylamine and at least one member selected from the group consisting of a hexafluoropropene trimer represented by C9F18, a perfluoroalkenyl ether, and a perfluoropolyether.SOLUTION: The present disclosure provides a method for separating perfluorotripropylamine from a mixture B that comprises the perfluorotripropylamine and a mixture A comprising at least one member selected from the group consisting of a hexafluoropropene trimer represented by C9F18, a perfluoroalkenyl ether, and a perfluoropolyether. The freezing point of the mixture A is at a temperature equal to or lower than the freezing point of perfluorotripropylamine, and the step of separating perfluorotripropylamine from the mixture A is performed at a temperature equal to or lower than the freezing point of perfluorotripropylamine.SELECTED DRAWING: None

The presently claimed invention relates to an alkaline composition for cleaning a substrate comprising i) copper or copper alloy and ii) cobalt or cobalt alloy, the composition comprising: a) at least one pH adjustor selected from diglycolamine, 4,4-diethoxy-N,N-dimethyl-1-butanamine, 3-dimethylaminopropan-1-ol, dimethylaminoethoxyethanol, N,N-dimethylisopropanolamine, ethylethanolamine, N-methyldiethanolamine, 2-(2-(methylamino)ethoxy)ethanol, 3-(methylamino)propane-1,2-diol, 2-[2-[2-(2-methoxy- ethoxy)ethoxy]ethoxy]ethylamine, 2-[2-(2-aminoethoxy)-ethoxy]-ethanol, N-butyldiethanolamine, diisopropanolamine, N-methyldiisopropanolamine, monoethanolamine, 3-dimethylamino-1,2-propandiol, 2- amino-1-butanol, 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol, prolinol, 1-methyl-2-pyrrolidinemethanol, 1-methyl-2-pyrrolidinemethanol, 1-methyl-3-pyrrolidinol, 2-amino-2-methyl-1-propanol, N,N-dimethylethanolamine, butylethanolamine, diethylethanolamine, 3-methoxypropylamine, 4-(2-hydroxyethyl)morpholine, 4-(dimethylamino)cyclohexanol, 2-amino-2-methyl-1, 3-propanediol, or diisopropylamine; b) at least one complexing agent selected from C2 to C12 hydrocarbon having at least two sulfonic acid or carboxylic acid groups; c) at least one polymeric dispersing agent having a weight average molecular weight ≥ 1000 g / mol; and d) a solvent comprising water.

The invention provides a method for preparing a 2-acyl pyrrole compound, and belongs to the technical field of organic chemical preparation, and the specific synthesis method is as follows: in an organic solvent, beta-carbonyl propargylamine is used as a starting material, and under the action of a silver catalyst and alkali, in an oxygen atmosphere, a reaction is performed for 2-6 hours at the temperature of 60-80 DEG C; the 2-acyl pyrrole compound is synthesized in one step through a cascade reaction of hydroalkylation and oxidative dehydrogenation in an alkyne molecule; according to the synthesis method, raw materials are simple and easy to obtain, reaction conditions are mild, operation is easy, the number of reaction steps is small, atom economy is high, the 2-acyl pyrrole compound is directly obtained through one-step reaction, and the yield can reach 82%.

The invention belongs to the technical field of electrolysis, and discloses a method for preparing p-hydroxyanisole through electrolytic oxidation of anisole. The method comprises the following steps: S1, adding anisole, an acylation reagent, an organic alkali proton trapping agent and an alkaline amine group-containing solvent into a single-chamber electrolytic bath together, starting electrification, carrying out electrolysis, and obtaining a product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the single-chamber electrolytic bath after electrolysis is finished; the organic base proton trapping agent is at least one of N, N-diisopropylethylamine, tributylamine and tripropylamine; and S2, adding a saturated sodium bicarbonate aqueous solution into the product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the step S1 to hydrolyze p-methoxytrifluoroacetic acid phenyl ester, and extracting to obtain p-hydroxyanisole. The selectivity of para-position and ortho-position products of methoxyl on anisole is regulated and controlled, so that the selectivity of p-hydroxyanisole prepared by the method is higher.

The invention discloses a synthesis method of a high-purity and high-yield antihypertensive drug, and relates to the technical field of medical chemistry. The method comprises the following steps: taking glycollic acid as an initial raw material, and carrying out acylation to obtain glycollic acid acyl chloride; carrying out Friedel-Crafts reaction on the 2-hydroxyl-5-(2-hydroxyacetyl) benzamide and salicylamide to obtain 2-hydroxyl-5-(2-hydroxyacetyl) benzamide; then, a Dess-Martin oxidizing agent is used for oxidation, and 2-hydroxy-5-(2-oxoacetyl) benzamide is obtained; the preparation method comprises the following steps: taking 2-hydroxyl-5-((4-phenylbutylamine-2-yl)-ethyl) benzamide as a raw material, then carrying out reductive amination on the 2-hydroxyl-5-(4-phenylbutylamine-2-yl)-ethyl) benzamide and 1-methyl-3-phenylpropylamine under the condition that sodium borohydride is taken as a reducing agent to obtain 2-hydroxyl-5-(1-hydroxyl-2-((4-phenylbutylamine-2-yl)-amino) ethyl) benzamide, namely And finally salifying with concentrated hydrochloric acid, crystallizing and separating to obtain the labeolol hydrochloride. The method is novel in route, convenient to operate, high in product total yield, high in purity, capable of effectively avoiding generation of dibromo impurities and suitable for large-scale production.

The invention provides an antifouling wear-resistant acrylic plate and a preparation method thereof, and belongs to the technical field of acrylic plates. The preparation method comprises the following steps: preparing the modifier; modifying the carbon nano tube; preparing an antifouling additive; and preparing the antifouling wear-resistant acrylic plate. The preparation method comprises the following steps: respectively dissolving polysuccinimide and dopamine hydrochloride, mixing for reaction, adding 3-dimethylaminopropylamine for reaction, and finally adding 1, 3-propane sultone for reaction to obtain a modifier containing zwitter-ion groups, modifying acidified carbon nanotubes by using the modifier, and then adding the zwitter-ion groups into the modified carbon nanotubes to obtain the modified carbon nanotubes with the zwitter-ion groups. The wear resistance and the antifouling property of the prepared acrylic plate can be obviously improved.

The present invention relates to a 3-aryloxyl-3-five-membered heteroaryl propylamine compound, and crystal form and use thereof. Specifically, the present invention provides a compound, or a pharmaceutically acceptable salt or a prodrug thereof, the compound having a structure of formula I. The compound, or pharmaceutically acceptable salt or prodrug thereof of the present invention has an excellent inhibition function for a transient receptor potential channel protein (TPR), and has a good treatment function for diseases associated with the TPR.

The invention discloses a bentazone intermediate sulfonation-chlorination two-step continuous preparation process which comprises the following steps: continuously metering and adding a solvent, chlorosulfonic acid, triethylamine, isopropylamine and a catalyst into a first-section tubular reactor, and carrying out sulfonation reaction to obtain a reaction material isopropylaminosulfonic acid; continuously introducing the reaction material isopropylamine sulfonic acid into a second section of tubular reactor, and simultaneously continuously metering and adding methyl anthranilate and phosphorus oxychloride for chlorination reaction; after the reaction is finished, quenching the reaction liquid with water, and carrying out layering and distillation treatment to obtain an intermediate o-isopropylamine sulfonamide methyl benzoate solid; and carrying out ring-closure reaction on the intermediate o-isopropylamino sulfonamido methyl benzoate solid and sodium methoxide in a methanol solution to prepare the bentazone active compound. According to the method, the defects of low bentazone product content and poor yield caused by high temperature of intermittent sulfonation and chlorination are effectively overcome, the operation time is shortened, and the productivity is improved.

The invention relates to the technical field of medicine and intermediate preparation, in particular to a synthetic method of 2-cyclopropylamino-3-nitro-6-chloropyridine. The preparation method comprises the following steps: taking 2, 6-dichloro-3-nitropyridine and cyclopropylamine as raw materials, taking silica gel as a catalyst, and carrying out substitution reaction on the 2, 6-dichloro-3-nitropyridine and the cyclopropylamine in the presence of the catalyst and an organic solvent, so as to obtain the 2-cyclopropylamino-3-nitro-6-chloropyridine. Aiming at the problems of poor reaction selectivity, troublesome purification operation and difficulty in amplification in the existing preparation of 2-cyclopropylamino-3-nitro-6-chloropyridine, silica gel is used as a catalyst, so that the generation of byproducts is greatly reduced, the reaction selectivity and the yield are improved, the use of column chromatography purification is avoided, and a qualified product can be obtained only by pulping.