645 results about "Substitution reaction" patented technology

The invention provides a method for preparing squaric acid and a method for preparing a lithium supplement agent of lithium squarate. The method for preparing squaric acid comprises the steps of preparing an intermediate I, preparing an intermediate II and preparing squaric acid. The method for preparing the squaric acid is a novel squaric acid synthesis route, and the squaric acid is obtained through cycloaddition / substitution reaction of perchloroprene serving as an initial raw material and morpholine, hydrolysis / rearrangement reaction in a buffer system and acid hydrolysis reaction in sequence. The method for preparing squaric acid has the advantages of simple reaction steps, mild reaction conditions, high yield, low cost and the like. The invention also provides a method for preparing the lithium squarate lithium supplement agent, and the prepared squaric acid and lithium-containing alkali are blended in a solvent for reaction to generate the lithium squarate. The method for preparing the lithium squarate lithium supplement has the advantages of simple reaction steps, mild reaction conditions, high yield, low cost and the like.

The invention provides a preparation method of a bexagliflozin intermediate, and relates to the technical field of organic synthesis. The preparation method provided by the invention comprises the following steps: S1, substitution reaction: under the action of alkali, carrying out substitution reaction on 2-(cyclopropoxy) ethanol and a compound III ((5-halogen-2-chlorphenyl) (4-halophenyl) ketone) to generate a compound II; s2, reduction reaction: under the action of lewis acid, carrying out reduction reaction on a reducing agent and a compound II ((5-halogen-2-chlorphenyl) (4-(2-(cyclopropoxy) ethyoxyl) phenyl) ketone) to generate a compound I; the method has the advantages of mild reaction conditions, high atom utilization rate, high yield, high product quality and the like.

The invention provides a preparation method and application of an asymmetric dicyclopentadienyl dialkoxy zirconium compound, and the preparation method comprises the following steps: (1) mixing a solvent with ZrCl4 and sodium cyclopentadienyl CpNa, and carrying out a reaction to obtain CpZrCl3; (2) the CpZrCl3 obtained in the step (1) and R1 substituted sodium cyclopentadienyl R1CpNa are subjected to a mixed reaction, and (R1Cp) CpZrCl2 is obtained; and (3) mixing the (R1Cp) CpZrCl2 obtained in the step (2) with alkoxy sodium salt R2Na, and carrying out a reaction so as to obtain the asymmetric dicyclopentadiene dialkoxy zirconium compound. According to the method, the substitution reaction of three sodium salts is used for replacing the ligand replacement reaction in the prior art, so that the reaction steps are shortened, the use of unnecessary raw materials is avoided, the production cost is reduced, and the obtained target product is high in yield and high in purity.

The invention discloses a novel BOPP (biaxially-oriented polypropylene) pearlized film loaded with a composite antibacterial material as well as a preparation method and application of the novel BOPP pearlized film, and the specific scheme is as follows: a KH550 coupling agent is hydrolyzed, a hydrolysate is modified on nano titanium dioxide (TiO2) particles, a natural antibacterial material eugenol (Eug) is brominated by a substitution reaction, and an Eug-TiO2 composite antibacterial material is further prepared based on nucleophilic substitution. And finally, carrying out melting plasticizing, extrusion casting and two-way stretching on polypropylene and pearlescent master batch to prepare the novel BOPP antibacterial pearlescent film, so that the strong activity, high stability, long action time, safety and environmental protection of the antibacterial process of the BOPP pearlescent film are realized, the added value attribute of the BOPP product is improved, and the application scene of the BOPP pearlescent film is expanded.

The invention discloses a smoke-suppression flame-retardant ecological board and a preparation method thereof. The ecological board comprises a base material, a flame-retardant adhesive layer and a facing layer which are sequentially stacked, wherein the flame-retardant adhesive layer is prepared from the following raw materials: 100 parts of urea-formaldehyde resin, 10-15 parts of a phosphorus-nitrogen composite flame retardant and 5-10 parts of flame-retardant filler; the preparation method of the phosphorus-nitrogen composite flame retardant comprises the following steps: carrying out an aminomethylation reaction on p-hydroxybenzoic acid, ethanolamine and paraformaldehyde which are used as raw materials in a molar ratio of 1: (1-1.2): (2-2.2) to prepare a Mannich base intermediate; and carrying out substitution reaction on the Mannich base intermediate and phosphonitrilic chloride trimer serving as raw materials according to the molar ratio of (3-7): 1. The phosphorus-nitrogen flame retardant disclosed by the invention is high in content of phosphorus and nitrogen elements and uniform in distribution ratio, and has more excellent synergistic smoke suppression and flame retardant effects compared with an existing physical compound system.

The invention relates to the technical field of organic dyes, in particular to a novel xanthene dye for blue photoresist color paste and a synthesis method of the novel xanthene dye. The invention relates to a synthesis method of a novel xanthene dye for blue photoresist color paste, which comprises the following steps: 1) taking rigid cyclic amine as a nucleophilic reagent, and carrying out aromatic nucleophilic substitution reaction on a chlorinated xanthene compound to obtain a xanthene intermediate; 2) performing chlorination reaction on the xanthene intermediate by using a chlorination reagent to obtain a chlorinated xanthene intermediate; 3) mixing active amine and the chlorinated xanthene intermediate, and performing substitution reaction under the action of alkali to obtain the novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste has the advantages of being high in solubility, good in thermal stability and high in contrast ratio.

The invention discloses a cellulose acetate based 1, 8-naphthalimide fluorescent probe for detecting Hg < 2 + > as well as a preparation method and application of the cellulose acetate based 1, 8-naphthalimide fluorescent probe. The preparation method comprises the following steps: by taking 4-bromo-1, 8-naphthalic anhydride as a raw material, carrying out condensation reaction on the 4-bromo-1, 8-naphthalic anhydride and 4-aminobutyric acid to prepare 4-(4-bromo-1, 8-naphthalic diimide) butyric acid (BNA-B); the BNA-B and piperazine are subjected to a substitution reaction, and a compound PNA-B is prepared; the PNA-B and 4-(bromomethyl) pyridine hydrochloride are subjected to a substitution reaction, and a compound PNA-B is prepared; and the PNA-B and cellulose acetate (CA) are subjected to an esterification reaction, such that the cellulose acetate-based 1, 8-naphthalimide fluorescent probe PNA-CA is prepared. The compound can specifically recognize Hg < 2 + >, after Hg < 2 + > is added into a PNA-CA acetonitrile / PBS buffer solution under 365nm ultraviolet irradiation, the fluorescence color of the solution is changed from colorless to yellow, the response time is 20s, the detection limit reaches 9.3 * 10 <-8 > M, and the probe has a good application prospect.

The invention relates to a preparation method of (S, S)-2, 8-diazabicyclo [4, 3, 0] nonane and an intermediate of the (S, S)-2, 8-diazabicyclo [4, 3, 0] nonane. Specifically, the invention discloses a method for preparing (S, S)-2, 8-diazabicyclo [4, 3, 0] nonane from a cheap raw material 2-chloronicotinic acid through an esterification reaction, a substitution reaction, a reduction reaction and an asymmetric hydrogenation reaction, and the method is novel in route, simple to operate, high in product yield, good in purity, safe, environment-friendly and very suitable for industrial production.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a benzocrown ether derivative and a synthesis method thereof. According to the invention, carboxylic acid or substituted carboxylic acid as shown in a general formula I, benzocrown ether as shown in a general formula II and substituted terephthalaldehyde as shown in a general formula IV are used as raw materials, and two kinds of benzocrown ether derivatives as shown in a general formula (A) and a general formula (B) are synthesized through Friedel-Crafts acylation reaction, reduction reaction and substitution reaction. The preparation method provided by the invention has the advantages of simple and easily available raw materials, simple post-treatment, high yield, good universality, environmental friendliness and the like. The two benzocrown ether derivatives as shown in the general formula (A) and the general formula (B), which are disclosed by the invention, serve as important organic synthesis intermediates and have great research values in the aspects of ion recognition, material preparation, medicine synthesis and the like.

The invention discloses a synthesis method of helicid, and relates to the technical field of compound synthesis, glucose is taken as an initial raw material, allose is obtained through a series of reactions, pentaacetyl allose is prepared from allose through acetylation reaction, tetraacetyl alloside is prepared through selective deacetylation reaction, substitution reaction and nucleophilic substitution reaction, and the helicid is synthesized through a one-step method. And finally, carrying out a deacetylation reaction on the tetraacetyl alloside to prepare helicid. Helicid has the effects of calming, sleeping, easing pain and resisting inflammation, and can be applied to preparation of medicaments with corresponding effects. The preparation method of the helicid provided by the invention is simple to operate, can be used for large-scale industrial production, and overcomes the defect of insufficient yield of naturally extracted helicid.

The present invention belongs to the technical field of covalent organic frameworks, and particularly relates to a method for preparing a single-crystalline vinylidene-bridged covalent organic framework. The method for preparing a single-crystalline vinylidene-bridged covalent organic framework comprises: mixing a single-crystalline imine-linked covalent organic framework, an active monomer, a catalyst and an organic solvent until uniform, and then performing a substitution reaction, wherein the substitution reaction is one or more of an aldol condensation reaction, a Knoevenagel condensation reaction, and a Claisen-Schmidt reaction. The single-crystalline vinylidene-bridged covalent organic framework having good stability, rich active sites, high photoelectric activity and a high conjugation degree is obtained by means of a substitution reaction of the single-crystalline imine-linked covalent organic framework and the active monomer under the action of a catalyst.

The invention discloses a sulfide solid electrolyte of a lithium ion battery, comprising: a sulfide solid electrolyte matrix comprising sulfur; the surface of the sulfide solid electrolyte matrix is coated with the coating layer, and the coating layer is formed by substitution reaction of metal chloride, 1-undecyl mercaptan and sulfur. The sulfide solid electrolyte disclosed by the invention is a sulfide solid electrolyte with high ionic conductivity and good interface stability at the same time. The invention also discloses a preparation method of the sulfide solid electrolyte, a composite sulfide solid electrolyte and a preparation method of the composite sulfide solid electrolyte.

The invention belongs to the technical field of drug synthesis, and relates to a dotenorad synthesis method, which comprises: weighing 100 g of a compound 1 as a raw material, and carrying out a substitution reaction with dimethyl sulfate to obtain a compound 2; taking the compound 2 as a raw material, and carrying out esterification reaction with methanol under an acidic condition; taking the compound 3 as a raw material, and obtaining a compound 4 after chlorination; hydrolyzing the compound 4 serving as a raw material to obtain a compound A; reacting the compound 5 serving as a raw material with a formaldehyde aqueous solution to obtain a compound 6; taking the compound 6 as a raw material, and performing thioether oxidation to obtain a compound B; taking a compound A as a raw material, and carrying out amide condensation reaction with a compound B to obtain a compound C; and 6, demethylating the compound C serving as a raw material under the action of lithium chloride to obtain a compound D, namely the final product dotenorad. According to the synthesis method of dotenorad, oxidation after condensation is not needed, generation of by-products is avoided, raw materials are low in cost and easy to obtain, and the synthesis method is suitable for industrial production.

The invention relates to a suzertraline intermediate as well as a preparation method and application thereof, and particularly provides a suzertraline intermediate 3, 4-difluoro-2-methoxyphenylacetic acid compound and a preparation method thereof, and the suzertraline intermediate can be used for preparing 3, 4-difluoro-2-methoxyphenylacetic acid. Specifically, 2, 3, 4-trifluoronitrobenzene which is low in price and easy to obtain serves as a starting raw material, 3, 4-difluoro-2-methoxyphenylacetic acid is prepared through a substitution reaction, a methylation reaction, a reduction reaction, a Meerwein arylation reaction and a hydrolysis reaction, the method is mild in reaction condition, a reaction substrate better meets the economic and environment-friendly requirements, reaction operation and a post-treatment process are safe and simple, and the method is suitable for industrial production. The purification steps are simple and convenient, byproducts are few, a target product with high purity can be obtained conveniently, corrosion to equipment is small, special equipment is not needed, and the method is suitable for industrial production.

The invention relates to the technical field of synthesis of propargyl chloride, in particular to a synthesis method of propargyl chloride. When 3-chloropropyne is synthesized by a conventional method, the yield is difficult to reach 90% or above. In order to solve the technical problems, the invention provides the synthesis method of the propargyl chloride, and propargyl alcohol and hydrogen chloride are subjected to substitution reaction in an organic solvent to generate the 3-propargyl chloride under the action of a closed reactor and a catalyst. According to the method for synthesizing the 3-chloropropyne, the yield of the 3-chloropropyne is larger than or equal to 90%, and the generation amount of by-products is smaller than 5%. The by-product hydrogen chloride is directly used as a synthesis raw material, so that the raw material cost is remarkably reduced. The method is mild in reaction condition, low in equipment investment and suitable for industrial amplification.

The invention provides a method for catalyzing hydrogen-deuterium replacement of heterocyclic aromatic hydrocarbon by using a binary cheap metal, and belongs to the technical field of organic synthesis.The method comprises the steps that a heterocyclic aromatic hydrocarbon compound serves as a raw material, heavy water and a binary cheap metal catalyst are added under the condition that a solvent is added or not added, under inert gas protection, heating is conducted for hydrogen-deuterium replacement reaction, and after the reaction is finished, a product is obtained; and separating and purifying the product to obtain the heterocyclic aromatic hydrocarbon deuterated compound. The preparation method provided by the invention adopts cheap heavy water as a deuterium source and cheap double-element metal as a catalyst, so that the cost is low, the operability is high, the applicability is wide, and the deuteration rate is high; a cheap and efficient heterocyclic aromatic hydrocarbon deuteration technology is realized, and the limitation of the existing heterocyclic aromatic hydrocarbon deuteration technology is solved.

The invention discloses a phototherapy reagent and a preparation method and application thereof. The preparation method comprises the following steps: 1-[4-(diethylamino) phenyl]-ethane-1-ketone and 4-methoxybenzaldehyde are subjected to a condensation reaction in a NaOH ethanol solution, and a product and nitromethane are subjected to addition; performing condensation and addition on the other groups of raw materials by the same method; cyclizing the two addition products with ammonium acetate, and coordinating with boron trifluoride diethyl etherate to obtain NHM; carrying out substitution reaction on the NHM and sodium nitrite to obtain NOO; and oxidizing NOO by m-chloroperoxybenzoic acid to obtain NNOO. The reagent can target a tumor hypoxia microenvironment, hypoxia monitoring is achieved, NO is released through photostimulation for tumor gas therapy, meanwhile, the secondary amplification photo-thermal therapy effect is achieved, preparation is controllable, diagnosis and treatment are integrated, and the reagent is sensitive, safe and suitable for biomedical research and clinical diagnosis.

The invention discloses an ultrasonic response quaternary ammonium salt polymer antibacterial agent and a preparation method thereof. The ultrasonic response quaternary ammonium salt polymer is prepared by the following steps: carrying out substitution reaction on azodiisobutylimidazoline and acryloyl chloride, then carrying out addition polymerization reaction with 4-aminomethylpiperidine, and then carrying out quaternization reaction with bromohexane. The obtained ultrasonic response quaternary ammonium salt polymer can be decomposed under the ultrasonic action to generate alkyl radicals, and has the sterilization effect. In addition, quaternary ammonium salt modification can improve the water solubility and the positive charge density of the polymer, and further improves the antibacterial performance.

The present invention relates to a preparation method for a novel benzylsulfinylpyridine compound, comprising using fluoropyridine, which contains electron-withdrawing substituents (such as halogen, trifluoromethyl, nitro, and cyano groups), as a starting material, and carrying out a substitution reaction and an oxidation reaction to obtain benzylsulfinylpyridine. According to the preparation method, a series of novel benzylsulfinylpyridine compounds can be obtained.

The application discloses a multifunctional biological imbibition agent and a preparation method and application thereof. The preparation method of the multifunctional biological imbibition agent comprises the following steps: (S1), alkylization reaction to obtain alkyl naphthalene; (S2), chloromethylation reaction to obtain halomethyl alkyl naphthalene; (S3), halogen alkyl nucleophilic substitution reaction to obtain hydroxymethyl alkyl naphthalene; and (S4), esterification reaction to obtain the multifunctional biological imbibition agent. The application further discloses application of the multifunctional biological imbibition agent as an imbibition agent in shale oil reservoir oil extraction. The application has the following advantages: (1) the reservoir adsorption amount is small, but the good wetting reversal characteristic is still maintained, and the emulsification is weak; (2) the high-temperature resistance is strong, and the temperature resistance reaches above 200 DEG C; (3) the preparation process is simple, and the yield is high; (4) the dosage is small, the cost is low, and the economic benefit is remarkable.

The application provides a synthesis process of metrafenone, in which inorganic alkali KOH is used as a catalyst, a key intermediate 4-(((5,5-dimethyl-dihydroisoxazole-4-yl)thio)methyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol can be obtained at low production cost and high yield, metrafenone is prepared through substitution reaction and oxidation reaction, the reaction yield is high, raw materials are simple and easy to obtain, three-waste emissions are small, and the process is beneficial to industrial mass production.

This invention belongs to the field of catalyst technology, providing a CO purification oxygen-rich catalyst, its preparation method, and its application. The preparation method involves dispersing γ-alumina in water, then sequentially adding copper nitrate and cerium nitrate to obtain a reaction solution. The reaction solution is mixed with an inorganic base, followed by a substitution reaction and a crystallization reaction to obtain a catalyst precursor. The catalyst precursor is calcined under a reducing atmosphere to obtain the CO purification oxygen-rich catalyst; the reducing atmosphere includes hydrogen. This preparation method generates sufficient active sites through a copper-cerium binary system, and then utilizes the basic groups provided by the inorganic base to form a low-valence metal-hydroxyl composite structure under a reducing atmosphere. Through the combined action of metal atoms, hydroxyl groups, and active oxygen sites, the research goals of high efficiency, stability, high selectivity, and economy are achieved. Furthermore, this preparation method does not use precious metals, resulting in low cost.

The invention belongs to the technical field of synthesis of ester compounds, and particularly relates to a preparation method of 2, 6-dichloro-4-cyanobenzoic acid methyl ester, which comprises the following steps: by taking dimethyl 2-aminoterephthalate as a raw material, sequentially carrying out substitution reaction, deamination reaction, hydrolysis reaction, amidation reaction and dehydration reaction to obtain the 2, 6-dichloro-4-cyanobenzoic acid methyl ester. The 2, 6-dichloro-4-cyanobenzoic acid methyl ester is prepared by the method, and the yield reaches 59.28%. The N-chlorosuccinimide is used as a chlorine source to carry out substitution reaction on the 2-amino dimethyl terephthalate, so that the potential safety hazard caused by the traditional chlorination reagent is avoided, and the tert-butyl nitrite used in the deamination reaction avoids the potential safety hazard caused by the use of strong corrosive sulfuric acid; the amidation reaction is completed in one step by adopting a condensing agent, so that the complicated operation caused by firstly preparing acyl chloride and then carrying out condensation reaction is avoided, and therefore, the preparation method has the characteristics of safe preparation process, environment friendliness, simplicity in operation and the like under the condition of ensuring the product yield and purity.

The invention discloses a continuous synthesis method of a cobalt-based alkyne precursor based on micro-reaction reinforcement, which belongs to the technical field of advanced electronic material preparation, and comprises the following steps: pre-cooling an n-hexane solution of Co2 (CO) 8 to-30 DEG C; the method comprises the following steps: introducing an n-hexane solution of Co2 (CO) 8 and 3, 3-dimethyl-1-butyne into a stacked microreactor array under the protection of nitrogen to react, and collecting a product after the reaction is completed. According to the present invention, the micro-channel reaction system containing the passivation layer is constructed, the substitution reaction process is precisely regulated and controlled, and the in-situ detection technology is combined so as to achieve the directional synthesis and collection of the specific coordination structure; the obtained product has excellent thermal stability and vapor pressure characteristics, and can meet the requirements of advanced semiconductor device manufacturing on precursor materials.

This invention provides a method for preparing and applying a highly insecticidal diamide compound, relating to the chemical and pesticide fields. The method includes: reacting 2-fluoro-3-nitrobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound A; condensing compound A with 2-trifluoromethyl-4-heptafluoroisopropyl-6-bromoaniline amide to obtain compound B; reducing compound B to obtain compound C; and, during the reaction under a hydrogen atmosphere, determining the reaction temperature and hydrogen flow rate in each hydrogenation reaction zone based on the concentration of compound B; reacting compound C with paraformaldehyde to obtain compound D; chlorinating 3-chloro-4-fluorobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound E; and amide condensing compound E with compound D to obtain the novel diamide compound of this invention. The diamide compound of this invention exhibits excellent insecticidal effects when used in pesticide compositions.

The invention provides a preparation method of a dihalo-substituted dibenzo [b, f] aza-5-formyl chloride compound, which is prepared from a compound II through dihalo substitution reaction. The method is reasonable in process, high in reaction yield and suitable for large-scale industrial production. In the reaction formula, R1 can be a halogen substituent such as bromine, chlorine or iodine, and R2 can be H, C1-C6 alkoxy and the like.

The invention discloses an acrylic acid silane ester self-renewal antifouling resin based on cation-pi interaction as well as a preparation method and application of the acrylic acid silane ester self-renewal antifouling resin. Methyl methacrylate, ethyl acrylate, triisopropylsilyl methacrylate, acrylic acid-2-methyl ethyl ester, paeonol methacrylate and acryloyloxyethyl trimethyl ammonium chloride are synthesized through a random free radical polymerization reaction with azodiisobutyronitrile and benzoyl peroxide as initiators. Wherein the methacrylic acid paeonol ester monomer is prepared by carrying out substitution reaction on paeonol and methacryloyl chloride. The anti-fouling agent is anchored on the surface of the coating again through cation-pi interaction, so that the anti-fouling effect is enhanced, and the coating still has good anti-fouling capacity even in a static environment.

The invention relates to a bis (2, 2-methylene disulfide) episulfide compound with an ultrahigh refractive index and a preparation method thereof, and belongs to the technical field of optical materials, and the preparation method comprises the following preparation steps: taking chloroacetaldehyde dimethyl acetal, a solvent, disulfur dichloride and an acidifying agent, and carrying out a sulfuration substitution reaction to prepare 2-chloro-1, 2-dithiol; the preparation method comprises the following steps: carrying out nucleophilic substitution reaction on methoxycarbonyl sulfonyl chloride, a low-boiling-point solvent and 2-chloro-1, 2-ethanedithiol, and dropwise adding a bicarbonate saturated aqueous solution to carry out cyclization reaction so as to prepare a methoxycarbonyl disulfide-episulfide compound; and adding dimercaptomercaptan, and reacting to obtain a product. The process route provided by the invention solves the problems of tedious step-by-step reaction, more byproducts and high cost in the prior art.

The invention discloses a synthesis method of an inner piroxostat key intermediate and a synthesis method of inner piroxostat. The invention provides a novel synthesis method of an inner piroxostat key intermediate 5, 7-difluoro-1, 2, 3, 4-tetrahydronaphthalene-2-amine, which comprises the following steps: taking 3, 5-difluorobenzyl bromide as a raw material, carrying out substitution reaction on the 3, 5-difluorobenzyl bromide and methane tricarboxylic acid triethyl ester, then carrying out hydrolysis decarboxylation, adding 1, 2, 3, 4-tetrahydronaphthalene-2-amine, and carrying out reaction to obtain the 5, 7-difluoro-1, 2, 3, 4-tetrahydronaphthalene-2-amine. The preparation method comprises the following steps: substituting 1, 2-diiodoethane, catalyzing carbon-hydrogen activation and ring closing by tetrakis (triphenylphosphine) palladium, hydrolyzing and decarboxylating, amidating, and carrying out Hofmann degradation reaction to obtain a target intermediate. The method has the advantages of cheap and easily available raw materials, simple synthesis and high yield, avoids the use of ethylene, sodium azide and other reagents, and is green and safe. The invention provides a method for further synthesizing the endopiroxostat based on the synthesis method, the method comprises a novel endopiroxostat hydrochloride chiral resolution method, the chiral pure endopiroxostat is conveniently prepared through a chiral preparative column, and the ee value is 100%.

The application relates to the technical field of organic synthesis, and discloses a synthesis method of benzthiazuron, which comprises the following steps: step 1, addition reaction of alpha-methyl styrene and hydrogen chloride gas, and degassing to obtain a first reaction liquid; step 2, substitution reaction of the first reaction liquid and cyanate in the presence of a zinc chloride catalyst, and filtration to obtain a second reaction liquid containing isocyanate; and step 3, construction of an inorganic salt aqueous solution system with a density of 1.05-1.10 g / ml and a pH of 9-10, dropwise addition of the second reaction liquid into the system for condensation reaction with o-chlorobenzylamine, and post-treatment and refinement to obtain a target product. The non-phosgene route of chloro-isocyanate substitution is adopted, and the use of the toxic phosgene is completely avoided; the salting-out effect and interface control generated by the specific high-density salt solution effectively inhibit the isocyanate hydrolysis side reaction, and the reaction yield and product purity are obviously improved.