This invention belongs to the technical field of preparing tetrahydropyridazine derivatives. The method provided by this invention is simple to operate and does not require an external
metal catalyst. The target product contains both a
diazoxide and a tetrahydropyridazine skeleton, making it a potential intermediate in the pharmaceutical and materials fields. This invention provides a method for preparing tetrahydropyridazine derivatives, which involves adding a compound having general formula 1, tert-butyl
peroxide, and
sodium bicarbonate to a solution of
acetone, as shown in the following reaction equation: