The invention discloses an adhesion and anticoagulation double-layer
blood vessel patch based on controllable delivery of a
balloon. The adhesion and anticoagulation double-layer
blood vessel patch comprises an adhesion
drug-loading outer layer and an anticoagulation inner layer, the
adhesive drug-loading outer layer is mainly prepared from a first solution, and the
anticoagulant inner layer is mainly prepared from a second solution; the patch outer layer is composed of wet adhesion hydrogel, and the surface of the patch outer layer is provided with microneedle structures arranged in the
blood flow direction. And the outer layer is physically embedded on the inner wall of the
blood vessel through
chemical bond combination. The inner layer is composed of anticoagulation hydrogel,
thrombus formation is effectively prevented, and blood vessels are kept unobstructed. The outer layer can be loaded with a
medicine for inhibiting
smooth muscle hyperplasia and
inflammation, and the inner layer is loaded with an
anticoagulant medicine, so that the atherosclerosis is treated, and the smooth
blood flow is ensured at the same time. The patch and the
balloon interface are combined through a photo-thermal separable lipid-
polymer bonding layer. The annular
laser optical fiber emits near-
infrared light at a target part to locally heat and melt the bonding layer, so that accurate and controllable release of the patch on the surface of the
balloon is realized.