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981results about How to "Reduce signal to noise ratio" patented technology

Control of polymer surface molecular architecture via amphipathic endgroups

Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.
Owner:THE POLYMER TECH GROUP

High-speed structure illumination optical microscope system and method based on digital micromirror device

The invention relates to a high-speed structure illumination optical microscope system and a method based on a digital micromirror device. The high-speed structure illumination optical microscope system comprises an illumination light source, a light splitting prism, a structure light generator, a lens, a spectroscope, a microobjective, an objective table, a reflector, a tubular mirror and a charge coupled device (CCD) camera, wherein the light splitting prism is arranged on a light path of the illumination light source, the structure light generator is arranged on a reflection light path of the light splitting prism, the lens is arranged on a transmission light path of the light splitting prism, the spectroscope is arranged on a lens light path, the microobjective and the objective table are arranged on a light path above the tubular mirror, the reflector and the tubular mirror are arranged on a light path under the spectroscope, and the CCD camera is arranged behind the tubular mirror. The system and the method aim at the technical problems of low optical energy utilization rate and low speed of the existing structure illumination microscope and have the advantages that the image refreshing speed is high (32KHz), and the optical energy utilization rate is high (higher than 90 percent). The system and the method are more applicable to the real-time three-dimension image study and high-speed dynamic process observation of living biological cells.
Owner:XI'AN INST OF OPTICS & FINE MECHANICS - CHINESE ACAD OF SCI

Receiver

A receiver determines a symbol synch time for recovering data from a symbol of signal samples generated in accordance with Orthogonal Frequency Division Multiplexing. Each symbol includes a guard period which carries data repeated from a data bearing part of the symbol and pilot signal samples. The receiver comprises a pilot assisted tracker which is operable to determine an adjustment to the symbol synch time from a pilot assisted channel impulse response estimate, a guard adapted filter processor comprising a filter and a filter controller operable to adapt the impulse response of the filter to the signal samples from the guard period. The controller is operable to excite the filter with the symbol signal samples to generate an output signal which provides a further representation of the channel impulse response. A symbol time adjustment estimator is operable to adjust the symbol synch time in accordance with the adjustment provided by at least one of the pilot assisted tracker and the guard adapted filter processor. The receiver provides an improved estimate of the symbol synch time by combining a pilot assisted tracker with a guard adapted filter processor. The pilot assisted tracker estimates the symbol synch time from a channel impulse response estimate generated from pilot signal samples. By combining the synch time adjustment estimated from the pilot assisted channel impulse response, with the adjustment estimated by the guard adapted filter processor, an ambiguity in a relative time of arrival of signal paths of the channel impulse response with respect to the main signal path is obviated.
Owner:SONY UK LTD +1

Detection of analytes using electrochemistry

The present invention relates to diagnostic assays whereby the detection means is based on electrochemical reactions. This means that the label to be detected provides an electric signal. Preferred labels are enzymes giving such a signal. Provided is a flow cell whereby a solid phase is provided in a flow stream of the sample, in close proximity to a working electrode to detect any electrical signal. In a typical embodiment, a sample is mixed with molecule having specific binding affinity for an analyte of which the presence in the sample is to be detected, whereby said specific binding molecule is provided with a label. The conjugate of labelled specific binding molecule and analyte is then immobilized on the solid phase in the vicinity of the working electrode, the flow cell is rinsed with a solution and afterwards a substrate solution for the label (an enzyme) is provided upon which an electrical signal is generated and can be detected by the working electrode. The methods and devices of the present invention are particular useful for liquids which comprise many substances that may disturb measurement in conventional assays. The design of the flow cell allows for removal of said interfering substances before measurement. In a preferred embodiment at least part of the solid phase is provided in the form of magnetic beads. In this embodiment the solid phase can be mixed with the sample thereby creating a longer reaction time, a better sensitivity and a higher speed of the assay.
Owner:DSM NV
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