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An electrosurgical generator for supplying RF power to an electrosurgical instrument for cutting or vaporising tissue has an RF output stage (42) with an RF power bridge (Q1, Q2, Q3, Q4), a pair of output lines (74) and a series-resonant output network (48). The output impedance of the output stage (42) at the output lines (74) is less than 200/√P ohms, where P is the maximum continuous RF output power of the generator. The generator offers improved cutting and vaporising performance, especially in relation to the reliability with which an arc can be struck when presented with an initial low impedance load. Overloading of the output stage is prevented by rapidly operating protection circuitry responsive to a predetermined electrical condition such as a substantial short-circuit across the output lines. In the preferred embodiment, the output stage is capable of maintaining output pulses at least 1kW peak by supplying the power bridge from a large reservoir capacitor (60). Pulsing is dynamically variable in response to load conditions by controlling the maximum energy per pulse in response to the reservoir capacitor voltage.

Azatriphenylene derivatives and their use in the electron-transporting layer of an electroluminescent device that comprises an anode, a spaced-apart cathode, and at least one electron-transporting layer disposed between the spaced-apart anode and cathode. Such EL devices provide lower drive voltage, improved power efficiency, and longer operational lifetime.

Medical devices, and in particular implantable medical devices, including self-expanding stents, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment.

A tissue bonding article includes a flexible material, an adhesive substance applied over at least a portion of a bottom side of the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material.

This invention relates to a system and method for interactive, adaptive, and individualized computer-assisted instruction. This invention includes an agent for each student which adapts to its student and provides individualized guidance to the student and controls to the augmented computer-assisted instructional materials. The instructional materials of this invention are augmented to communicate the student's performance and the material's pedagogical characteristics to the agent and to receive control from the agent. Preferably, the content of the communication between the agent and the materials conforms to specified interface standards so that the agent acts independently of the content of the particular materials. Also preferably, the agent can project using various I/O modalities integrated, engaging, life-like display persona(e) appropriate to the preferences of its student and appear as a virtual tutor to the student. Finally, preferably this invention is implemented on computers interconnected by a network so that instruction can be delivered to geographically distributed students from geographically distributed servers. An important application of this invention is delivering interactive, adaptive, and individualized homework to students in their homes and other locations.

Disclosed herein are methods and devices for repairing articular surfaces in a knee joint. The articular surface repairs are customizable or highly selectable for each patient and geared toward providing optimal fit and function. Kits are also provided to enable customized repairs to be performed.

The present invention relates to the field of ambulatory and non-invasive monitoring of a plurality of physiological parameters of a monitored individual. The invention includes a physiological monitoring apparatus with an improved monitoring apparel worn by a monitored individual, the apparel having attached sensors for monitoring parameters reflecting pulmonary function, or parameters reflecting cardiac function, or parameters reflecting the function of other organ systems, and the apparel being designed and tailored to be comfortable during the individual's normal daily activities. The apparel is preferably also suitable for athletic activities. The sensors preferably include one or more ECG leads and one of more inductive plethysmographic sensor with conductive loops positioned closely to the individual to preferably monitor at least basic cardiac parameters, basic pulmonary parameters, or both. The monitoring apparatus also includes a unit for receiving data from the sensors, and for storing the data in a computer-readable medium. The invention also includes systems comprising a central data repository for receiving, storing, and processing data generated by a plurality of physiological monitored apparatus, and for making stored data available to the individual and to health care providers.

A novel networking architecture and technique for transmitting both cells and packets or frames across a common switch fabric, effected, at least in part, by utilizing a common set of algorithms for the forwarding engine (the ingress side) and a common set of algorithms for the QoS management (the egress part) that are provided for each I/O module to process packet/cell information without impacting the correct operation of ATM switching and without transforming packets into cells for transfer across the switch fabric.

Disclosed herein is a gas distribution plate for use in a gas distribution assembly for a processing chamber, where the gas distribution plate is fabricated from a solid yttrium oxide-comprising substrate, which may also include aluminum oxide. The gas distribution plate includes a plurality of through-holes, which are typically crescent-shaped. Through-holes which have been formed in the solid yttrium oxide-comprising substrate by ultrasonic drilling perform particularly well. The solid yttrium oxide-comprising substrate-typically comprises at least 99.9% yttrium oxide, and has a density of at least 4.92 g/cm³, a water absorbency of about 0.02% or less, and an average grain size within the range of about 10 μm to about 25 μm. Also disclosed herein are methods for fabricating and cleaning the yttrium oxide-comprising gas distribution plate.

A composite filtration medium web of fibers containing a controlled dispersion of a mixture of sub-micron and greater than sub-micron diameter polymeric fibers is described. The filtration medium is made by a two dimensional array of cells, each of which produces a single high velocity two-phase solids-gas jet of discontinuous fibers entrained in air. The cells are arranged so that the individual jets are induced to collide in flight with neighboring jets in their region of fiber formation, to cause the individual nascent fibers of adjacent jets to deform and become entangled with and partially wrap around each other at high velocity and in a localized fine scale manner before they have had an opportunity to cool to a relatively rigid state. The cells are individually adjusted to control the mean diameters, lengths and trajectories of the fibers they produce. Certain cells are adjusted to generate a significant percentage of fibers having diameters less than one micron diameter, and which are relatively shorter in length and certain other cells are adjusted to generate a significant percentage of structure-forming reinforcing fibers having diameters greater than one micron diameter which are relatively longer in length. By employing appropriate close positioning and orientation of the cells in the array, the sub-micron fibers are caused to promptly entangle with and partially wrap around the larger reinforcing fibers. The larger fibers thereby trap and immobilize the sub-micron diameter fibers in the region of formation, to minimize the tendency of sub-micron diameter fibers to clump, agglomerate, or rope together in flight. Also, the larger fibers in flight are made to form a protective curtain to prevent the sub-micron fibers from being carried off by stray air currents.

An enhanced natural language information retrieval technique tokenizes an incoming query, comparing the tokenized representation against a collection of query templates. Query templates include a first portion having one or more query patterns representative of a query and in a form suitable for matching the tokenized representation of an incoming query. Query templates also include one or more information retrieval commands that are designed to return information relevant to those query patterns in its first portion. The enhanced natural language information retrieval technique selects those query templates that are determined to be most relevant to the incoming query (via its tokenized representation) and initiates one or more information retrieval commands associated with the selected query templates.

Floorboards with a format corresponding to a traditional parquet block for laying of mechanically joined floating flooring. Rectangular floorboards include a surface layer and a core with two long sides and two short sides, for making a floating flooring, which floorboards are mechanically lockable and which along their four sides have pairs of opposing connectors for locking similar, adjoining floorboards to each other both vertically and horizontally wherein the long sides have a length not exceeding 80 cm and the short sides have a width not exceeding 10 cm.

This invention relates to a system and method for interactive, adaptive, and individualized computer assisted instruction. This invention includes an agent (108) for each student (101) which adapts to its student, and provides individualized guidance to the student and controls to the augmented computer assisted instructional materials. The instructional materials of this invention are augmented to communicate the student's performance and the material's pedagogical characteristics to the agent, and to receive control from the agent. In a preferred embodiment, the agent maintains data reflecting the student's pedagogic or cognitive characteristics in a protected and portable media in the personal control of the student. Preferably, the content of the communication between the agent and the materials conforms to specified interface standards, so that the agent acts independently of the content of the particular materials. Also preferably, the agent can project using various I/O modalities integrated engaging, lifelike display personna(e).

A moving picture variable bit rate coding apparatus receives digitized moving pictures and subjects them to coding according to a variable bit rate method using real time processing in response to the input of the pictures. The apparatus performs variable bit rate coding in real time by sequentially performing blocking, conversion processing, quantization processing, and generation of bit streams in response to the input of digitized moving picture data, and setting a quantization scale used for quantization corresponding to a quantity of generated bit streams to perform coding processing and control of quantization in parallel.

Disclosed are compositions and a method for amplification of nucleic acid sequences of interest. The disclosed method generally involves replication of a target sequence such that, during replication, the replicated strands are displaced from the target sequence by strand displacement replication of another replicated strand. In one form of the disclosed method, the target sample is not subjected to denaturing conditions. It was discovered that the target nucleic acids, genomic DNA, for example, need not be denatured for efficient multiple displacement amplification. The primers used can be hexamer primers. The primers can also each contain at least one modified nucleotide such that the primers are nuclease resistant. The primers can also each contain at least one modified nucleotide such that the melting temperature of the primer is altered relative to a primer of the same sequence without the modified nucleotide(s). The DNA polymerase can be φ29 DNA polymerase.

A plurality of linked gaming machines are disclosed that enhance the community participation and enjoyment of a game on multiple gaming machines. Players participate in an interactive game, either simultaneously, alternatively or in a systematic sequence, as a group or community. The participating players compete in the game such that the actions and results of each player affect the other players in the community. The interactive game combines skill and luck to improve play of the game. The interactive game could be a bonus game which players need to qualify in order to participate. If a player does not qualify, a wager can be placed to participate in the game. Players with different wagers can participate in the same game and players can wager on the outcomes of other players.

An image guided navigation system for navigating a region of a patient which is gated using ECG signals to confirm diastole. The navigation system includes an imaging device, a tracking device, a controller, and a display. The imaging device generates images of the region of a patient. The tracking device tracks the location of the instrument in a region of the patient. The controller superimposes an icon representative of the instrument onto the images generated from the imaging device based upon the location of the instrument. The display displays the image with the superimposed instrument. The images and a registration process may be synchronized to a physiological event.

Disclosed herein are finger-worn devices in various embodiments, and related systems, interfaces and methods of use. In some embodiments, a finger-worn device may be connected and disconnected from other devices. In some embodiments, a finger-worn device may relay tactile information to a finger wearing said finger-worn device, and/or to a finger operating said finger-worn device. In some embodiments, a finger-worn device may be operated to generate sound, whereas in some embodiments, a finger-worn device may be operated to generate visual output. In some embodiments, interfaces are intended to react, or be controlled or influenced by a finger-worn device or plurality thereof. In some methods, a finger-worn device may be operated for registering input in systems which can sense and process sounds, whereas in other methods a finger-worn device may be operated for registering input in systems which can sense and process light.

A virtual interactive environment enables a surgeon or other medical professional to manipulate implants, prostheses, or other instruments using patient-specific data from virtual reality models. The patient data includes a combination of volumetric data, surface data, and fused images from various sources (e.g., CT, MRI, x-ray, ultrasound, laser interferometry, PET, etc.). The patient data is visualized to permit a surgeon to manipulate a virtual image of the patient's anatomy, the implant, or both, until the implant is ideally positioned within the virtual model as the surgeon would position a physical implant in actual surgery. Thus, the interactive tools can simulate changes in an anatomical structure (e.g., bones or soft tissue), and their effects on the external, visual appearance of the patient. CAM software is executed to fabricate the implant, such that it is customized for the patient without having to modify the structures during surgery or to produce a better fit.

Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.

A focused ultrasound ablation device and method includes an ultrasound emitting member having a plurality of individual ultrasound emitting elements arranged in an array. The ultrasound emitting elements are actuatable to emit ultrasound energy and focus the emitted ultrasound energy a predetermined distance from the ultrasound emitting member such that the ultrasound energy is focused within anatomical tissue adjacent which the ultrasound emitting member is positioned. The anatomical tissue is heated by the ultrasound energy focused therein to form an internal lesion within the tissue. The ultrasound emitting elements are selectively, independently actuatable, allowing selected ones of the ultrasound emitting elements to be actuated to emit ultrasound energy to obtain a lesion of desired or selected size and/or surface configuration in the tissue of a particular patient.

A shunt and method of use for maintaining distal blood flow during an arteriotomy procedure is disclosed. The shunt includes first and second tubular members having proximal ports, distal ports, and lumens therebetween. The distal port of the second tubular member is adapted for releasable attachment to the proximal port of the first tubular member. A second lumen merges and communicates at its distal end with the lumen of the first tubular member and includes a hemostatic valve attached to its proximal end. In using the apparatus for performing open endarterectomy, a filter device is inserted into the vessel and deployed downstream the region of interest in the internal carotid artery. The distal end of the shunt is advanced over the filter device and secured onto the artery. The proximal end of the shunt is inserted upstream the region of interest, typically in the common carotid artery.