1657 results about "Artery" patented technology

A non-invasive physiological sensor system implemented as a smart watch or other wearable device includes an emitter for emitting light and a detector for collecting light after the light interacts with a tissue of a wearer. The system can measure light intensity at one or more radial distances to estimate attenuation parameter values that can be used to correct physiological parameter bias across subjects. In addition or alternatively, the system can determine whether a detector is positioned sufficiently proximate to an obstructing tissue (for example, an artery or vein) so as to cause inaccurate measurements by the detector.

The invention relates to the technical field of intelligent medical systems, and discloses a cerebral apoplexy onset risk assessment and reminding method and system.The method comprises the steps that continuous medical structured detection data are collected, and the data comprise carotid artery blood flow parameters, brain oxygen saturation, heart rate variability and metabolic indexes; inputting a bidirectional LSTM, a differential convolutional network, a wavelet residual network and a multi-layer perceptron to extract nonlinear features; constructing a neural function coupling structure diagram of four nodes of cerebral blood supply, oxygen supply, autonomous regulation and metabolic steady state; calculating inter-node time sequence offset correlation and a stable factor to obtain a coupling anomaly coefficient; and driving the embedded network by using a graph structure and a node feature input mechanism, and outputting a risk state assessment result. According to the method, the neural function coupling structure diagram is constructed and the mechanism is introduced to drive the embedded network, so that high-precision identification of the multi-system collaborative abnormal state and dynamic evaluation of the stroke risk level are realized.

An intra-vessel transcatheter filter device (1) designed to capture and remove emboli, thus preventing distal embolization, comprising: • a tubular filter (2) comprising a flexible porous material and defined by a distal element and a proximal element, namely a main body (3) and a funnel (4); i. said main body (3) having a length adapted to extend within a suitable vessel zone; said main body (3) comprising: a) a distal end (5) that is adapted to be radially coupled with said zone and hermetically sealed to it when the device is in an active configuration, said distal end (5) being provided of selectively actionable closure means so that said distal end is designed to be open when the device is in an active configuration and closed before the device retraction, b) a proximal end (6); ii. said funnel (4) forming an extension of said main body (3), with the funnel base located at said proximal end (6). • a support structure assembly (8) comprising: i. a supporting catheter (11) extending within said main body (3), ii. one radially expandable distal structure (9) fixed to said distal end (5), iii. one radially expandable proximal structure (10) positioned in correspondence of said proximal end (6), said distal structure (9) and said proximal structure (10) being fixed at least in an end to said supporting catheter (11).

Medical systems, devices, and methods for determining whether a blood vessel is a vein or an artery. The system includes an optical fiber configured for insertion into a blood vessel coupled with a console having a light source, an optical receiver, processors, and logic stored in memory. The optical fiber includes sensors disposed along its length configured to determine a state or condition of the optical fiber. The state or condition can include a strain, movement, pressure, and / or temperature. The logic is configured to analyze reflected signals from the sensors to determine whether the optical fiber is inserted within an artery or within a vein. The logic may also determine a red-blue shift of a projected light to determine a blood flow direction with respect to the optical fiber.

The invention discloses an anesthesia strategy generation system fusing time sequence data and a knowledge graph, and relates to the technical field of medical information processing. The method specifically comprises the steps that five types of vital sign data including arterial blood pressure, electrocardio and electroencephalogram are collected, correction is conducted in combination with traction marks and electrotome interference characteristics, and an analysis result is output; the inference analysis module executes double-track processing based on the analysis value, one track evaluates cortical suppression, shock and ventilation risks and generates a risk report, and the other track performs reverse arbitration when the blood oxygen data is abnormal; constructing a knowledge graph fusing the efficacy nonlinear cooperation equation, the age sensitive parameters and the drug administration sequence influence; and the strategy generation module integrates the multi-source data to generate a drug execution track, and executes fast and slow closed-loop regulation and control based on a risk report and an arbitration result. According to the invention, the adaptation capability of the system to individual differences, the abnormal signal identification and processing capability and the intelligent response level of the anesthesia strategy are improved, and the accuracy and safety of clinical anesthesia are significantly enhanced.

The invention discloses an artificial heart valve near-physiological pulsation fluid external evaluation device and method, and relates to the technical field of heart valve testing.The artificial heart valve near-physiological pulsation fluid external evaluation device comprises a supporting frame, a driving unit, a tested valve installation unit and an artery and peripheral loop unit, the driving unit provides power for liquid flowing, and the tested valve installation unit is used for fixing an artificial heart valve; and a liquid volume assembly and a resistance assembly of the artery and peripheral loop unit can simulate the compliance and resistance of aorta blood vessels and peripheral artery blood vessels, so that the pressure waveform simulation of the systemic circulation loop is more accurate. On the basis of the air cavity, the elastic corrugated pipes with different frequency responses are arranged, the compliance and rebound resilience of the aorta are simulated, a device for rapidly replacing the tested valve is designed, and the mechanical property of the simulated human body aorta is adjusted by adjusting the parameters such as the output frequency and the vibration amplitude of the driving unit; real pressure and flow waveforms under different physiological / pathological conditions are simulated, and a more accurate and convenient detection environment is realized.

A method of extracting a thrombus from a thrombus site in a cerebral artery of a patient by advancing a first catheter into an internal carotid artery of the patient; advancing a funnel catheter within the first catheter; moving the funnel catheter and the first catheter with respect to each other to place the funnel outside of the first catheter; expanding the funnel into contact with an inner wall of the internal carotid artery at or proximal to a distal end of a carotid siphon, thereby reducing blood flow past the funnel; advancing a clot-mobilizer distally through the first catheter toward the thrombus and beyond the carotid siphon; engaging thrombus material from the thrombus with the clot-mobilizer; moving the clot-mobilizer and thrombus material proximally at least partially into the funnel; applying suction to aspirate thrombus material; and moving the funnel, the clot-mobilizer and the thrombus material proximally within the vasculature.

An ultrasound-imaging system includes an ultrasound probe coupled with a console. Operations of the system can include detecting one or more blood vessels within the ultrasound image and identifying each blood vessel as a vein, an artery or other anatomic element using doppler ultrasound functionality of the ultrasound probe. Operations can also include determining a confidence for the blood vessel identification and defining a window for doppler ultrasound operation. Operations can further include assessing a blood flow rate within blood vessels, and superimposing notifications atop the ultrasound image pertaining to the identity of the blood vessel including a confidence for the identity.

The embodiment of the invention provides a continuous blood oxygen monitoring system in extracorporeal circulation and a control method thereof. The continuous blood oxygen monitoring system comprises a vein sensor, an artery sensor, a blood flow sensor, an oxygen sensor, a carbon dioxide sensor, a controller and a display, the vein sensor monitors the vein blood oxygen saturation degree; the artery sensor monitors arterial oxygen saturation and hematocrit; the blood flow sensor monitors the blood flow of the artery pipeline; the oxygen sensor monitors the oxygen concentration of the oxygenator; the carbon dioxide sensor monitors the carbon dioxide concentration of the oxygenator; the display provides an interaction control, responds to a trigger operation acting on the interaction control, sends an interaction instruction to the controller, and updates information displayed in an interaction interface according to the control of the controller; the controller receives the interaction instruction and executes processing corresponding to the interaction instruction; the processing includes controlling display information of the display; the display information comprises information corresponding to the monitoring parameters. The scheme ensures the safety and effectiveness of the treatment process.

The invention provides a non-invasive blood pressure estimation method, device and equipment, a storage medium and a product, and belongs to the technical field of biomedicine, and the method comprises the steps that an ECG signal and an ICG signal are preprocessed; generating physiological feature indexes, wherein the physiological feature indexes comprise conventional indexes and special indexes; determining an incidence relation between the conventional index and the basic peripheral vascular resistance parameter as well as the basic artery compliance parameter; inputting the conventional indexes into a pre-trained machine learning model, and outputting basic peripheral vascular resistance prediction parameters and basic artery compliance prediction parameters; performing dynamic correction according to the special indexes, and generating a target peripheral vascular resistance parameter and a target artery compliance parameter; and calculating and generating a blood pressure estimation result. According to the non-invasive blood pressure estimation method, device and equipment, the storage medium and the product, the accuracy, dynamic nature and stability of non-invasive blood pressure estimation can be improved.

The invention discloses a non-contact ECG signal monitoring method based on a millimeter wave radar, belongs to the field of ECG signal monitoring, realizes high-precision electrocardiogram reconstruction by simultaneously sensing chest vibration caused by heartbeat and carotid artery pulsation from the neck and fusing spatial-temporal characteristics, and solves the problems that a traditional scheme depends on electrodes and an existing radar technology cannot recover complete ECG. According to the method, non-contact ECG signal monitoring is carried out in a daily scene, and good privacy and comfort are achieved.

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.

The invention discloses a non-invasive wearable vascular arteriosclerosis assessment system and method based on multi-mode pulse wave signal fusion, and belongs to the field of vascular function assessment. The system comprises a distributed acquisition front end, a butterfly-shaped flexible substrate, an integrated double-accelerometer, a four-wavelength LED (530nm / 660nm superficial blood vessel measurement), a 810nm / 940nm deep artery measurement device, a double-photodiode, a double-impedance electrode and a pressure sensor. The central integrated control end processes a multi-mode signal and realizes pressure-LED current closed-loop control; the upper computer terminal extracts the multi-modal pulse wave time difference of the limbs and the neck, the local and regional pulse wave conduction velocity and the blood oxygen hemoglobin change parameters induced by the standardized posture, the dimension is reduced to 30 through principal component analysis, then the parameters are input into the random forest regression model, and the vascular elasticity index is output. Signal stability is improved through flexible fitting, single-source limitation is solved through multi-modal fusion, signal quality is guaranteed through closed-loop control, sensitivity is enhanced through dynamic physiological excitation, and accuracy and universality of arteriosclerosis assessment are improved.

The invention relates to the technical field of image recognition, in particular to a carotid artery image analysis method and system based on deep learning and a medium. The method comprises the following steps: obtaining a heterogeneous carotid artery image set, and carrying out heterogeneous federal integrated processing to obtain a federal precoding image set; recognizing an image feature semantic co-occurrence mode based on the federal precoding image set so as to construct a high-order image semantic structure; performing multi-scale blood vessel semantic embedding on the federal precoding image set to obtain a multi-scale structure tensor; performing privacy enhancement contrast representation migration on the multi-scale structure tensor to obtain an encryption migration embedding set; and reversely mapping the encryption migration embedding set to a federal precoding image set, and carrying out image reconstruction scoring by taking a high-order image semantic structure as a reconstruction constraint, thereby obtaining a carotid artery image feature scoring matrix. The carotid artery image feature recognition accuracy and processing efficiency can be improved.

The invention relates to the technical field of medical instruments, in particular to a split type hemorrhoid artery ligation hemorrhoid suspension operation positioning device and application thereof. The device comprises an outer sleeve and an inner sleeve, the inner sleeve is movably and / or rotatably arranged in a cavity of the outer sleeve, the outer sleeve is provided with an outer sleeve operation window, the inner sleeve is provided with an inner sleeve operation window, and the outer sleeve operation window and the inner sleeve operation window can be moved or rotated. The outer sleeve operating window and the inner sleeve operating window are at least partially aligned with each other at at least one operating window position; the outer sleeve and the inner sleeve longitudinally extend to at least partially form a cylindrical or conical or truncated cone-shaped structure, the outer sleeve forms a tubular shell main body and a shell split body along the longitudinal extension direction, and the side edges of the tubular shell main body and the shell split body are detachably connected; an optical unit is arranged on the shell split body so as to irradiate the cavity of the outer sleeve.

The invention relates to the technical field of medical monitoring and intelligent decision making, and particularly discloses an intraoperative noninvasive real-time blood flow monitoring and medication intervention analysis system. Pulse wave oscillation harmonic component characteristics and diastolic attenuation characteristic characteristics are extracted by using variational mode decomposition and a polynomial fitting algorithm; the multi-dimensional features are fused and then input into a deep learning classification model, and accurate recognition of insufficient heart pump efficiency, abnormal peripheral vascular tension and circulation capacity imbalance states is achieved; time sequence prediction and grading early warning are carried out based on the hidden Markov model and the individualized baseline safety interval, and finally a targeted medication scheme is output through the intervention strategy knowledge base.

The invention relates to the field of physiological signal detection, and discloses a blood pressure measurement system based on brachial artery cuff pressurization and finger PPG detection, which comprises a pressure control module, a PPG acquisition module and a central processing unit. The central processing unit is configured to extract a multi-dimensional PPG feature vector from the PPG signal in real time; dynamically adjusting the change mode of the cuff pressure applied by the pressure control module in a closed-loop manner based on the change of the PPG feature vector; constructing a dynamic response map based on the synchronously recorded cuff pressure and PPG feature vector; and determining a blood pressure value based on the overall analysis of the dynamic response map. Determining the blood pressure value specifically includes identifying a systematic distorted phase transition point in the atlas to determine systolic pressure. Through closed-loop adaptive excitation and global trajectory analysis, blood pressure determination is established on the basis of hemodynamic state transition, dependence on isolated event points is avoided, and measurement robustness and accuracy are improved.

The invention provides a quantitative risk assessment method and system for head and neck artery stenosis, and the method comprises the steps: collecting the medical image of the head and neck artery of a patient, the blood pressure of the upper arm artery, and the heart rate; a narrow local form, a cerebral artery network anatomical structure / geometric size and a microcirculation blood flow automatic regulation mechanism are comprehensively incorporated into hemodynamic analysis through a geometric multi-scale modeling technology, and information such as an arterial stenosis far-end and near-end pressure ratio, cerebral artery blood flow and hemodynamic parameters of a narrow part is output; quantitative information support is provided for risk assessment of head and neck artery stenosis; the method has the advantages that patient data are obtained only through noninvasive measurement, and the risk that complications are increased due to invasive measurement is avoided; according to the method, a geometric multi-scale modeling method is adopted to achieve integrated analysis of the three-dimensional flow field and the whole-brain circulation hemodynamic parameters of the stenosis part, the blood flow regulation effect of brain microcirculation is considered, and the physiological significance and clinical application value of the evaluation result can be remarkably improved.

The invention discloses an artery plaque detection and evaluation method and device, and relates to the technical field of image recognition. The method comprises the following steps: acquiring a to-be-used image group, wherein the to-be-used image group comprises at least one modal magnetic resonance image; performing blood vessel wall segmentation operation on the to-be-used image group to obtain a binary blood vessel skeleton image; inputting the to-be-used image group and the binarized vascular skeleton image into a trained plaque segmentation model to obtain a binarized plaque mask combination; inputting the binarized plaque mask combination and the to-be-used image group into a trained plaque component recognition model to obtain a multi-label segmentation result image; and performing plaque vulnerability judgment according to the multi-label segmentation result image so as to obtain plaque vulnerability judgment information. According to the method, the problems of high subjectivity, poor generalization ability, sensitivity to image quality and the like caused by dependence on artificial feature extraction and threshold segmentation in a traditional method are solved.

The invention discloses a human body peripheral blood vessel photoacoustic three-dimensional imaging device and an imaging method thereof, and belongs to the field of blood vessel imaging. Through high resolution and functional monitoring capability of photoacoustic imaging, detailed blood vessel structure and blood flow dynamic information are provided, and early recognition and treatment effect evaluation of common lesions such as diabetic foot and peripheral artery diseases are promoted; meanwhile, a mechanical system is adopted, so that the detection front end with relatively high quality can be borne, and stable operation is realized, and a relatively good photoacoustic imaging result is obtained; the system has a highly stable accurate scanning imaging mode, and is convenient for multiple imaging modes of clinical application; through the arrangement of the imaging water tank and the lifting structure of the imaging water tank, switching of imaging modes in a limited space can be ensured, so that the device can be suitable for the layout of a portal type three-dimensional moving device. The system is expected to promote the portability of equipment, reduce the research and development cost of the equipment, be widely applied to clinical practice and community medical treatment, and improve the disease management level.

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

This invention, which offers the advantage of an automatic repetitive blood pressure measurement that minimizes discomfort for the subject while continuously measuring blood pressure regardless of the subject's movement, thereby enhancing the reliability of the measurement results, which leads to the development of an automatic repetitive blood pressure measurement device and method for a smart blood pressure monitor, relates to blood pressure measurement technology, involving periodically repeating the inflation and deflation of a cuff a set number of times upon receiving a single operation signal input. The method includes the steps of detecting arterial wall vibrations when the cuff pressure is between the systolic and diastolic pressures of the artery during cuff inflation and deflation, recognizing the point where maximum vibration is detected as the systolic blood pressure based on the detection results, recognizing the diastolic blood pressure if the vibration decrease exceeds a threshold, and providing measurement results sequentially, including the recognized systolic and diastolic blood pressure values during the repeated inflation and deflation of the cuff a set number of times.

Systems and methods are disclosed for simulation of occluded arteries and / or optimization of occlusion-based treatments. One method includes obtaining a patient-specific anatomic model of a patient's vasculature; obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model; obtaining a post-treatment computational model by modifying portions of the initial computational model based on an occlusion-based treatment; generating a pre-treatment blood flow characteristic using the initial computational model or computing a post-treatment blood flow using the post-treatment computational model; and outputting a representation of the pre-treatment blood flow characteristic or the post-treatment blood flow characteristic.

The invention discloses a traditional Chinese medicine composition with an effect of improving artery blood vessel plaque and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The technical problem to be solved is to provide a traditional Chinese medicine composition capable of improving vascular plaques such as carotid artery, aortic arch, brachial trunk, subclavian artery and the like aiming at the current situation that adverse reactions exist when statin lipid-lowering drugs and antiplatelet drugs are taken for a long time to treat artery vascular plaques. According to the technical scheme, the traditional Chinese medicine composition with the effect of improving the artery blood vessel plaque is characterized by comprising radix puerariae, red yeast rice, folium cortex eucommiae, hippophae rhamnoides leaves and natto.

The invention relates to the technical field of medical first-aid equipment, and provides intelligent cardio-pulmonary resuscitation equipment based on physical sign information fusion, which comprises a physical sign monitoring module which is integrated with an electrocardiogram monitoring unit, an end-tidal carbon dioxide (ETCO2) monitoring unit and a carotid artery blood flow ultrasonic sensor and is used for acquiring electrocardiosignals, ETCO2 concentration and carotid artery pulse data of a patient in real time; the circulation optimization module comprises an in-vitro double-lower-limb pressurization device, promotes lower limb vein blood backflow through periodic air pressure pressurization, and is provided with a pressure sensor for dynamically adjusting the pressurization intensity. Through the intelligent pressing mechanical arm, the pressing track and the springback strength can be dynamically adjusted according to the pressing effective coefficient (CCF), personal errors caused by fatigue of an operator and individual differences are avoided, high standardization and stability of pressing operation are achieved, cardio-pulmonary resuscitation effectiveness is remarkably improved, lower limb vein blood backflow is promoted through periodic air pressure pressurization, and the cardio-pulmonary resuscitation effect is improved. A pressure sensor is arranged to dynamically adjust the pressurization intensity, and the success rate of cardio-pulmonary resuscitation is increased.

The invention relates to an application of a histone H3K18 lactic acid modification related target in preparation of a medicine for preventing or treating atherosclerosis. The invention belongs to the field of biological medicine, and discloses histone acetyltransferase P300 and application of histone H3K18 lactylation (H3K18la) modification mediated by the histone acetyltransferase P300 as a new target spot for treating atherosclerosis (AS). Researches find that in the AS process, lactic acid accumulation in vascular smooth muscle cells (VSMCs) up-regulates H3K18la through P300 catalysis, and then the pathological phenotype of the VSMCs is induced, and plaque development is promoted. H3K18la can be reduced and the phenotype can be improved by inhibiting LDHA and MCT1 in vitro or knocking out a P300 gene; the P300 for in-vivo targeted inhibition of the VSMCs can significantly reduce the artery plaque. Therefore, the P300 and H3K18la inhibitors can be used for preparing the anti-atherosclerosis medicine.

The disclosed technology provides a device for sealing an aperture in a tissue of a body lumen. The device comprises a flexible support member having a base having (i) a central portion and (ii) one or more lateral support portions, to engage and / or hold a sealable member of the device against an interior surface of the tissue when the device is in the sealing position. The lateral support portions provide additional support surfaces to engage peripheral portions of the sealable member against the interior surface of the tissue. A cage or shoe engaged with the support member on the exterior surface of the tissue can provide additional support and assist sealing the aperture.

Systems and methods are provided for reducing the reliance on operator skill during vascular ultrasound procedures. The placement of an ultrasound probe to assess perfusion associated with a wound may be facilitated by receiving input suitable for identifying an anatomical region associated with the wound and providing an indication of a suitable initial probe position, and optionally, probe orientation, for acoustically interrogating a target arterial vessel known to provide perfusion to the anatomical region associated with the wound. Regions exhibiting arterial flow may be detected as the probe is moved, enabling arterial vessel detection and localization. A subregion within the detected arterial vessel and a beam steering angle may be autonomously determined for spectral Doppler data collection, enabling the measurement of hemodynamic measures associated with the arterial vessel. Example apparatus for securing the probe to the patient and facilitating probe positioning to search for a target vessel are disclosed.

Some disclosed blood pressure estimation methods involve controlling, by a control system, an ultrasonic sensor system to transmit ultrasonic waves to a target object on an outer surface of an apparatus, the ultrasonic sensor system having M ultrasonic receiver elements in a single array. Some such methods involve receiving, by the control system from the ultrasonic sensor system, ultrasonic receiver signals from each of a plurality of the M ultrasonic receiver elements in the single array, the ultrasonic receiver signals corresponding to ultrasonic waves reflected from the target object. Some such methods involve detecting, by the control system, an artery within the target object based on the ultrasonic receiver signals. Some such methods involve estimating, by the control system, a blood pressure within the artery based on the ultrasonic receiver signals.

The invention relates to the technical field of medical instruments, in particular to a femoral artery hemostasis device and a hemostasis method. Comprising a compression plate and a compression ball installed on the upper side of the compression plate, a first compression point is arranged in the center area of the top of the outer surface of the compression ball, an annular center mark is arranged on the top of the inner surface of the compression ball, and a plurality of second compression points are arranged on the outer surface of the compression ball and located below the first compression point at equal intervals in the circumferential direction. The inner surface of the compression ball is provided with an annular guide line used for marking second compression points, and the inner surface of the compression ball is further provided with a radial guide line with one end connected with the corresponding positions of the second compression points on the annular guide line and the other end pointing to the center mark. The privacy protection device further comprises a fixing adhesive tape, and a privacy curtain used for shielding privacy is arranged on the fixing adhesive tape. The hemostasis device is simple in structure and convenient to use, operation procedures are reduced, the adaptability of the ellipsoidal curved surface structure is good, the hemostasis efficiency is greatly improved, and the hemostasis effect is more remarkable.