3286 results about "Artery" patented technology

A non-invasive physiological sensor system implemented as a smart watch or other wearable device includes an emitter for emitting light and a detector for collecting light after the light interacts with a tissue of a wearer. The system can measure light intensity at one or more radial distances to estimate attenuation parameter values that can be used to correct physiological parameter bias across subjects. In addition or alternatively, the system can determine whether a detector is positioned sufficiently proximate to an obstructing tissue (for example, an artery or vein) so as to cause inaccurate measurements by the detector.

A method of extracting a thrombus from a thrombus site in a cerebral artery of a patient by advancing a first catheter into an internal carotid artery of the patient; advancing a funnel within the first catheter; moving the funnel and the first catheter with respect to each other to place the funnel outside of the first catheter; expanding the funnel into contact with an inner wall of the internal carotid artery at or proximal to a distal end of a carotid siphon, thereby reducing blood flow past the funnel; applying suction through the funnel; advancing a clot-mobilizer through the first catheter toward the thrombus; engaging thrombus material from the thrombus with the clot-mobilizer; moving the clot-mobilizer and thrombus material proximally at least partially into the funnel; and moving the funnel, the clot-mobilizer and the thrombus material proximally within the vasculature.

The invention discloses an automatic vein and artery puncture control method, which is used for realizing high-precision puncture through precise control, and comprises the following steps of: after determining to start automatic vein and artery puncture control, collecting a blood vessel ultrasonic image; aiming at the target blood vessel ultrasonic image data, establishing a static artery blood vessel detection model based on a lightweight deep network and a target detection algorithm; the blood vessel detection model is used for detecting and positioning blood vessels; collecting a blood vessel image to be detected and positioned in real time, and obtaining the position and category of the blood vessel based on the trained blood vessel detection model; determining a target blood vessel position based on blood vessel positioning and classification, wherein the target blood vessel position is a puncture target position; planning a puncture path based on the target blood vessel position, including vein puncture path planning and artery puncture path planning; and converting the path and the control parameters based on puncture path planning. The invention further discloses a device and a system, which have low requirements on working environment, can adapt to dynamic environment, are convenient to popularize, reduce puncture difficulty and labor intensity and are portable.

The invention relates to the technical field of health status assessment, in particular to a cardiovascular disease layered early warning system, which is characterized in that blood vessel compliance and pulse wave velocity are extracted, arterial dilation capacity is measured, blood vessel elasticity is calculated, blood perfusion distribution is detected, and abnormal vasoconstriction is classified on the basis of a hemodynamic state and a heart electrical activity state; in combination with the thickness of the blood vessel wall and the blood vessel stenosis rate, the plaque deposition condition is analyzed, the arteriosclerosis score is calculated, the thrombosis tendency is detected, the local blood flow blocking degree is quantified, the isolation forest algorithm is adopted, the blood flow dynamic change is calculated, the heart rhythm abnormality is analyzed, the acute vascular occlusion probability is measured, and the sudden heart rhythm abnormality risk is evaluated. And based on a gradient boosting tree algorithm, screening high-risk cases, matching medical intervention measures, setting a risk buffer mechanism, adjusting an individual health management strategy, and optimizing a cardiovascular risk hierarchical early warning system.

The invention relates to the technical field of intelligent medical systems, and discloses a cerebral apoplexy onset risk assessment and reminding method and system.The method comprises the steps that continuous medical structured detection data are collected, and the data comprise carotid artery blood flow parameters, brain oxygen saturation, heart rate variability and metabolic indexes; inputting a bidirectional LSTM, a differential convolutional network, a wavelet residual network and a multi-layer perceptron to extract nonlinear features; constructing a neural function coupling structure diagram of four nodes of cerebral blood supply, oxygen supply, autonomous regulation and metabolic steady state; calculating inter-node time sequence offset correlation and a stable factor to obtain a coupling anomaly coefficient; and driving the embedded network by using a graph structure and a node feature input mechanism, and outputting a risk state assessment result. According to the method, the neural function coupling structure diagram is constructed and the mechanism is introduced to drive the embedded network, so that high-precision identification of the multi-system collaborative abnormal state and dynamic evaluation of the stroke risk level are realized.

Systems and methods are disclosed for simulation of occluded arteries and / or optimization of occlusion-based treatments. One method includes obtaining a patient-specific anatomic model of a patient's vasculature; obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model; obtaining a post-treatment computational model by modifying portions of the initial computational model based on an occlusion-based treatment; generating a pre-treatment blood flow characteristic using the initial computational model or computing a post-treatment blood flow using the post-treatment computational model; and outputting a representation of the pre-treatment blood flow characteristic or the post-treatment blood flow characteristic.

An ultrasound probe includes a light source configured to project a visual indication onto a skin surface of the patient. The visual indication includes different visual characteristics that are based on characteristics of the anatomical target such as a location with respect to the probe and / or an identification of an anatomical target as a vein or as an anatomical element other than a vein, such as an artery. Visual characteristics include shapes, locations, and / or colors of the projected visual indication. Logic of the probe performs location and / or identification processes on ultrasound image data that may include applying trained machine-learning models to the ultrasound image data. Some embodiments, include a virtual / augmented reality headset and / or a needle tracking system. An ultrasound system includes machine-learning logic that generates the trained machine-learning models from historical ultrasound image data sets and actual anatomical target location / identification data sets.

The invention provides an early-stage automatic identification method and system for acute kidney injury related to cardiac surgery, and relates to the technical field of physiological parameter detection. The method comprises the following steps: acquiring average arterial pressure, cardiac blood discharge volume, central venous pressure and blood oxygen saturation, regularly recording and extracting data of adjacent time points, calculating a variation range, screening a mutation region, judging whether a reference range is exceeded or not, analyzing a multi-parameter synchronous variation condition, and marking a hemodynamics abnormal state. According to the method, abnormal changes of hemodynamics and urine metabolism are accurately recognized through real-time monitoring and multi-parameter analysis, the urine flow rate and the metabolite excretion rate are combined, misjudgment of a single index is avoided, the fineness of renal function change analysis is improved, the high-risk time period is accurately positioned through time cross comparison, the diagnosis accuracy is improved, and the diagnosis accuracy is improved. Trend analysis and risk grade division enable the change of the illness state to be more visual, and a real-time early warning system effectively monitors the fluctuation trend, optimizes clinical management and improves the timeliness of medical response.

The invention discloses an embolism part for peripheral arteriovenous vessels, the embolism part comprises an anchoring part and a blocking part fixedly connected with the anchoring part, the blocking part adopts polyurethane shape memory foam, the expansion rate of the polyurethane shape memory foam is 50-100 times, and a preparation method of the polyurethane shape memory foam comprises the following steps: step 1, preparing a polyurethane shape memory foam material; the preparation method comprises the following steps: preparing a polyurethane acrylate prepolymer from macromolecular polyol, diisocyanate, a chain extender containing disulfide bonds, other micromolecular chain extenders and an acrylate end-capping reagent; and 2, uniformly mixing the polyurethane acrylate prepolymer, a foaming agent, a foaming promoter and a photoinitiator to obtain a foaming solution, and sequentially carrying out light curing and foaming on the foaming solution to obtain the polyurethane shape memory foam. According to the embolism part, the polyurethane shape memory foam is adopted as the blocking part, the blocking part applies radial acting force to the wall of the blood vessel all the time based on the expansion trend of the blocking part, and the blocking part and the anchoring part jointly act and can be stably maintained in the blood vessel.

An ultrasound probe includes a light source configured to project a visual indication onto a skin surface of the patient. The visual indication includes different visual characteristics that are based on characteristics of the anatomical target such as a location with respect to the probe and / or an identification of an anatomical target as a vein or as an anatomical element other than a vein, such as an artery. Visual characteristics include shapes, locations, and / or colors of the projected visual indication. Logic of the probe performs location and / or identification processes on ultrasound image data that may include applying trained machine-learning models to the ultrasound image data. Some embodiments, include a virtual / augmented reality headset and / or a needle tracking system. An ultrasound system includes machine-learning logic that generates the trained machine-learning models from historical ultrasound image data sets and actual anatomical target location / identification data sets.

A sheath assembly for the insertion of a percutaneous pump includes a tubular sheath body dimensioned for insertion into a blood vessel through a vessel aperture. The tubular sheath body includes a wall having a proximal end portion, a distal end portion, a longitudinal axis, an outer surface, an inner surface defining a first lumen substantially parallel to the longitudinal axis, and a second lumen disposed within the wall between the inner surface and the outer surface and extending from the proximal end portion to the distal end portion. The first lumen is dimensioned to allow passage of a portion of the percutaneous pump, and the second lumen is dimensioned for passage of a guidewire. A stylet is removably positioned to substantially occlude the second lumen. The stylet has a proximal end releasably secured to the sheath assembly.

The invention relates to the technical field of image analysis, in particular to a three-dimensional hepatic duct, hepatic artery, portal vein and hepatic vein image segmentation method and system. The method comprises the following steps: acquiring multi-phase medical image data of a liver region; performing region identification on the image data, and extracting hepatic duct, hepatic artery, portal vein and hepatic vein regions; executing structure tracking on the hepatic duct area to obtain a hepatic duct positioning result; carrying out improved contrast extraction on the hepatic artery region to obtain hepatic artery positioning data; performing directional segmentation analysis on the portal vein region to obtain a portal vein positioning result; performing branch angle extraction on the hepatic vein region in combination with the portal vein direction to obtain hepatic vein positioning data; taking the hepatic artery as a reference structure, performing elastic registration on each blood vessel structure, and generating registration data under a unified coordinate; and completing three-dimensional visualization based on a registration result. According to the method, multi-stage image joint segmentation and registration are realized, and the method has the technical advantage of high structural recognition integrity.

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

An intra-vessel transcatheter filter device (1) designed to capture and remove emboli, thus preventing distal embolization, comprising: • a tubular filter (2) comprising a flexible porous material and defined by a distal element and a proximal element, namely a main body (3) and a funnel (4); i. said main body (3) having a length adapted to extend within a suitable vessel zone; said main body (3) comprising: a) a distal end (5) that is adapted to be radially coupled with said zone and hermetically sealed to it when the device is in an active configuration, said distal end (5) being provided of selectively actionable closure means so that said distal end is designed to be open when the device is in an active configuration and closed before the device retraction, b) a proximal end (6); ii. said funnel (4) forming an extension of said main body (3), with the funnel base located at said proximal end (6). • a support structure assembly (8) comprising: i. a supporting catheter (11) extending within said main body (3), ii. one radially expandable distal structure (9) fixed to said distal end (5), iii. one radially expandable proximal structure (10) positioned in correspondence of said proximal end (6), said distal structure (9) and said proximal structure (10) being fixed at least in an end to said supporting catheter (11).

The invention provides a CT image focus detection method and system based on artificial intelligence, and relates to the technical field of medical image processing, and the method comprises the steps: obtaining a plain-scan CT image and an enhanced CT image of a liver; determining first position information of a to-be-determined lesion area in the plain-scan CT image through an image detection model; according to the first position information and the arterial phase image, screening out a to-be-determined tumor focus area from the to-be-determined focus area, and determining second position information of the to-be-determined tumor focus area; according to the second position information and the portal pulse period image, the to-be-determined tumor focus area is classified, and the tumor focus area and a common focus area are determined; determining a warning level score according to the tumor focus area and the delay period image; and generating a liver focus detection report according to the warning level score. According to the invention, a complex screening and evaluation process can be automatically executed, and the probability of misjudgment is reduced.

The invention relates to a multi-mode heart and cerebral hemodynamics monitoring method and device, and belongs to the technical field of medical equipment. According to the method, brain absorbance information and pulse wave information at the middle artery of the brain are obtained based on a near infrared spectrum technology by utilizing the relevance among the cardiac output, blood pressure, intracranial pressure and cerebral perfusion pressure of a human body, cardiac output information and cuff-free blood pressure information are obtained based on a thoracic impedance method, and physiological signals are obtained based on the two methods; and carrying out fusion processing to obtain a multi-modal signal, and further constructing a non-invasive monitoring model of non-invasive intracranial pressure, cardiac output, blood pressure and cerebral perfusion pressure, so as to realize continuous non-invasive monitoring reflecting human heart and cerebral hemodynamic parameters. According to the invention, through fusion application of multi-mode signals, the mechanism of cardio-cerebral hemodynamics interaction can be effectively disclosed, and a more effective, safer and noninvasive monitoring means is provided for clinic.

A system leverages a multimodal model to predict peripheral arterial disease (PAD) risk. The system provides a dynamic questionnaire leveraging a language model to generate questions in response to user input. From the dynamic questionnaire, the system identifies user-specific risk factor(s) for PAD. The system also receives sensor data recorded by health sensor(s) including biometric signals of the user. The system applies a sensor classification model to the sensor data to output clinical data associated with a health state of the user. The system applies a multimodal PAD risk prediction model to the identified user-specific risk factors and the clinical data to output a PAD risk prediction indicating whether the user is at risk for PAD. Based on the outputs, the system generates and transmits one or more personalized recommendations for the user for treating or mitigating PAD risk and / or control instructions for controlling operation of the health sensor(s) and / or the medical device(s).

The invention discloses an intelligent pressure regulation and control method and system for artery compression, and the method comprises the steps: collecting the arterial blood pressure waveform and vascular elasticity parameters of a puncture part of a patient in real time, and the multi-dimensional pressure data of a pressure sensor; constructing an initial pressure parameter set containing a pressure distribution gradient and a vascular response coefficient through a dynamic feature extraction algorithm; carrying out collaborative analysis on the initial pressure parameter set and blood flow characteristic parameters obtained through blood flow monitoring, and generating a regulation and control matrix containing an optimal compression force range and a time decay function; performing multi-target optimization processing on the regulation and control matrix through a parallel optimization algorithm to generate a real-time pressure control instruction set; based on the deviation value of the real-time pressure execution data fed back by the user interface and the blood flow monitoring data, a grading alarm mechanism is triggered, and a compression strategy is automatically corrected. By utilizing the embodiment of the invention, accurate regulation and control of the artery compression process can be realized, and the hemostatic effect is optimized and the medical quality is improved on the premise of ensuring the safety of a patient.

The invention discloses a transfer control method and device for an ultrasonic robot to autonomously scan thyroid gland, and the method comprises the steps: controlling an ultrasonic robot probe to move from an initial position to a target side by a first preset distance, collecting an ultrasonic image in real time, and recording a total movement distance and a distance to a trachea; obtaining a thyroid contour area based on the ultrasonic image, and determining the effectiveness of the ultrasonic image; if the continuous preset number of ultrasonic images are valid, determining that the probe completes two-side transfer; otherwise, contour features of the trachea and the carotid artery are obtained based on ultrasonic image fitting, and whether the probe completes two-side transfer or not is determined by combining the distance from the probe to the center of the neck; if not, whether the distance to the air pipe is larger than a second preset distance is judged; if not, whether the total moving distance is larger than a preset maximum distance or not is judged; if not, transferring is executed again; and if yes, determining that the probe completes two-side transfer. According to the method, the quality and efficiency of thyroid autonomous scanning are improved, and the safety and accuracy of operation are enhanced.

The invention relates to lauroyl cilostazol as well as a preparation method and application thereof. Wherein the lauroyl cilostazol is sterile, and preferably, the lauroyl cilostazol is a crystal. The invention further provides application of the lauroyl cilostazol in preparing medicines for treating cerebral infarction, cerebrovascular diseases, atherosclerosis, diabetic complications, peripheral vascular diseases, Reynolds diseases, intermittent claudication, ischemic heart diseases and acute coronary syndromes. The lauroyl cilostazol has the remarkable long-acting characteristic.

The utility model discloses a femoral artery compression hemostat. Comprising a base plate, an installation part arranged at the upper end of the base plate, a pressing piece installed in the installation part, a pressure sensor arranged on the pressing piece, a side box arranged on one side of the installation part and a driving mechanism installed in the side box, wherein one end of the pressing piece penetrates out of the top of the installation part, and the other end of the pressing piece penetrates out of the bottom of the base plate. A plurality of fixing belts are detachably connected to the exterior of the mounting part, a display screen and an alarm are arranged outside the side box, a controller electrically connected with the pressure sensor, the display screen, the alarm and the driving mechanism is arranged in the side box, and the driving mechanism can drive the pressing part to reciprocate in the height direction of the mounting part. The size of the compression force is automatically controlled, the workload of medical staff is relieved, the size of the compression force can be visually displayed and accurately controlled, and the situation that the compression force is too large to cause pressure injury or too small to achieve the compression hemostasis purpose is avoided.

Medical systems, devices, and methods for determining whether a blood vessel is a vein or an artery. The system includes an optical fiber configured for insertion into a blood vessel coupled with a console having a light source, an optical receiver, processors, and logic stored in memory. The optical fiber includes sensors disposed along its length configured to determine a state or condition of the optical fiber. The state or condition can include a strain, movement, pressure, and / or temperature. The logic is configured to analyze reflected signals from the sensors to determine whether the optical fiber is inserted within an artery or within a vein. The logic may also determine a red-blue shift of a projected light to determine a blood flow direction with respect to the optical fiber.

The invention provides a peripheral artery disease patient rehabilitation management system based on a whole process, and relates to the technical field of peripheral artery disease patient rehabilitation management. The system comprises a patient screening and risk grading module, a rehabilitation evaluation module, an exercise prescription generation and dynamic adjustment module, an intelligent propaganda and education content pushing module and a quality control closed-loop management module. PAD patients are accurately screened through a medical data interface and an NLP technology, and the risk levels of the patients are dynamically evaluated in combination with an intelligent risk grading system; generating a personalized exercise prescription according to the evaluation report, complication and biological monitoring data, and guaranteeing the exercise safety through a dynamic threshold model and collaborative early warning; dynamic matching and timeliness pushing of propaganda and education contents are realized by using an improved KL divergence algorithm; and full-process quality closed-loop management is realized through the quality control closed-loop management module. The precision and safety of rehabilitation management of the PAD patient can be improved, medical resource configuration is optimized, and rehabilitation practice driven by full-process data is assisted.

According to various embodiments, machine learning techniques for determining a pharmacokinetic parameter of a radiotracer in a patient are presented. The techniques include: obtaining a time sequence of positron emission tomography (PET) scans of a target tissue of the patient, where the time sequence of PET scans includes images of a radiotracer in the target tissue; providing the time series of the PET scans to a first neural network system, which provides features extracted from the time series of the PET scans; providing the features extracted from the time series of the PET scans to a second neural network system, which provides an estimated arterial input function; modeling the pharmacokinetic parameter of the radiotracer based on the estimated arterial input function and the time sequence of PET scans; and outputting an estimate of the pharmacokinetic parameter of the radiotracer based on the modeling.

The invention provides an intelligent blood pressure measuring method and system based on an electronic Korotkoff sound method, and relates to the technical field of medical instruments.The method comprises the steps that in the process that a cuff wound around the upper arm of a person to be measured is deflated, multiple Korotkoff sound signals from a brachial artery and the air pressure, corresponding to the Korotkoff sound signals, in the cuff are obtained; determining the initial systolic pressure of the to-be-tested person according to the first air pressure in the cuff when the Korotkoff sound signal appears for the first time, and determining the initial diastolic pressure of the to-be-tested person according to the second air pressure in the cuff when the Korotkoff sound signal appears for the last time; performing feature value extraction on the plurality of Korotkoff sound signals to obtain a plurality of feature parameters; and inputting the plurality of characteristic parameters, the initial systolic pressure and the initial diastolic pressure into a preset neural network model to obtain target systolic pressure and target diastolic pressure of the to-be-measured person, and taking the target systolic pressure and the target diastolic pressure as blood pressure measurement results of the to-be-measured person. The method has the technical effect that the accuracy of blood pressure measurement is improved.

The utility model discloses a cardiovascular intervention postoperative artery wound compression device, which relates to the technical field of wound compression devices and comprises a shell, two sides of the shell are movably connected with two sides of a bandage, an adjusting mechanism is arranged at the bottom of the shell and comprises a circular ring, and the inner side of the circular ring is slidably connected with the bottom of the shell. The inner side of the shell is slidably connected with a pressing block, the front portion and the rear portion of the pressing block are both fixedly connected with threaded blocks, the outer sides of the threaded blocks are in meshed connection with the inner side of a circular ring, the inner side of the top of the shell is rotationally connected with a rotating disc, the bottom of the inner side of the pressing block is fixedly connected with the bottom of a rack, and one side of the rack is in meshed connection with the front portion of a gear. One side of the gear is fixedly connected with a worm, the rear portion of the worm is connected with a worm gear in a meshed mode, through the adjusting structure, the effect that the compression pressure can be observed is achieved, and the problem that in a traditional wound compression device, the wound compression force cannot be accurately controlled according to the pulse pressure of a patient is solved.

The utility model discloses a microcatheter assembly with an OCT probe, and relates to the technical field of medical instruments. A microcatheter assembly with an OCT probe, comprising: a microcatheter; the micro-catheter is provided with a first side hole; the first side hole is close to the front end of the micro catheter; a micro guide wire; the micro guide wire is matched with the first side hole; a balloon and an OCT probe; the balloon and the OCT probe are both arranged on the micro catheter. The balloon and the OCT probe are both arranged in the micro catheter, so that the balloon or the OCT probe does not need to be frequently pulled out of or inserted into the cerebral artery during use, and only the balloon or the OCT probe needs to move in the cerebral artery by a small distance (dozens of millimeters or dozens of millimeters). Compared with the prior art, the operation difficulty in use is small, the operation time is short, the risk that the inner wall of the cerebral artery of a patient is damaged can be reduced, and other risks borne by the patient in an operation can also be reduced.

The present application belongs to the field of medical device technology, and discloses a blood purification device and an operation method thereof, wherein the device comprises: a mobile trolley, a fixed bracket, a purification mechanism and an abnormal monitoring mechanism; a fixed bracket is provided on the mobile trolley, and a purification mechanism is provided on the fixed bracket; an abnormal monitoring mechanism is fixedly provided on the fixed bracket; the purification mechanism comprises an arterial pot, a dialyzer, a venous pot, a blood pump, a replacement fluid storage box, an ultrafiltrate collection box, a dialysate storage box, a replacement fluid pump, an ultrafiltrate pump, an arterial tube, a venous tube, a dialysate pump and a heparin pump, and a purification capacity evaluation module is fixedly provided on the fixed bracket. The present invention continuously monitors the blood purification process through the abnormal monitoring mechanism, promptly discovers abnormal conditions in the blood purification process, evaluates the dialysis effect of the dialyzer according to the monitoring data, and ensures that when the main dialyzer fails or has problems, the standby dialyzer can be immediately activated by setting two dialyzers, so as to ensure the continuity of the dialysis process and the safety of the patient.

The invention discloses a method for noninvasive diagnosis of pulmonary arterial hypertension and a related device, and relates to the technical field of artery detection.The method comprises the steps that an echocardiogram result and right heart catheter pulmonary artery pressure data of a suspected pulmonary artery patient are obtained; the echocardiogram result is a tricuspid regurgitation spectrum; grading the quality of the tricuspid regurgitation spectrum based on a TR spectrum quality grading standard according to the regurgitation spectrum missing degree of the tricuspid regurgitation spectrum; according to the echocardiogram result and the right heart duct pulmonary artery pressure data, on the basis of the quality grading result of the tricuspid regurgitation spectrum, a personalized pulmonary artery hypertension diagnosis model suitable for different patients is constructed; according to the pulmonary arterial hypertension diagnosis model, on the basis of the echocardiogram result of the target pulmonary arterial patient, a pulmonary arterial hypertension diagnosis result of the target pulmonary arterial patient is obtained, and personalized accurate diagnosis can be carried out on different pulmonary arterial hypertension patients under the noninvasive condition.

The present invention provides a system and method for treating tight, hard-to-cross calcified lesions in which an angioplasty balloon is used to dilate the lesions and provide shock waves to restore normal blood flow in a patient's artery. An exemplary device includes an elongated tube and a balloon wrapped circumferentially around the tube and sealed to a distal end of the tube. During treatment, the device is advanced into a patient's vasculature and the balloon is inflated with conductive fluid such that the balloon is fixed to walls of the vasculature proximal to the calcified lesion. The balloon includes at least one low-profile emitter positioned near the distal end of the balloon, which may be activated to generate shock waves to break loose calcifications in the lesion. After calcium in the tight lesion has been modified, the balloon can be deflated and advanced further into the lesion to continue treatment.