1151 results about "Artery" patented technology

A method of extracting a thrombus from a thrombus site in a cerebral artery of a patient by advancing a first catheter into an internal carotid artery of the patient; advancing a funnel catheter within the first catheter; moving the funnel catheter and the first catheter with respect to each other to place the funnel outside of the first catheter; expanding the funnel into contact with an inner wall of the internal carotid artery at or proximal to a distal end of a carotid siphon, thereby reducing blood flow past the funnel; advancing a clot-mobilizer distally through the first catheter toward the thrombus and beyond the carotid siphon; engaging thrombus material from the thrombus with the clot-mobilizer; moving the clot-mobilizer and thrombus material proximally at least partially into the funnel; applying suction to aspirate thrombus material; and moving the funnel, the clot-mobilizer and the thrombus material proximally within the vasculature.

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.

The invention relates to the technical field of image recognition, in particular to a carotid artery image analysis method and system based on deep learning and a medium. The method comprises the following steps: obtaining a heterogeneous carotid artery image set, and carrying out heterogeneous federal integrated processing to obtain a federal precoding image set; recognizing an image feature semantic co-occurrence mode based on the federal precoding image set so as to construct a high-order image semantic structure; performing multi-scale blood vessel semantic embedding on the federal precoding image set to obtain a multi-scale structure tensor; performing privacy enhancement contrast representation migration on the multi-scale structure tensor to obtain an encryption migration embedding set; and reversely mapping the encryption migration embedding set to a federal precoding image set, and carrying out image reconstruction scoring by taking a high-order image semantic structure as a reconstruction constraint, thereby obtaining a carotid artery image feature scoring matrix. The carotid artery image feature recognition accuracy and processing efficiency can be improved.

The invention relates to the technical field of medical instruments, in particular to a split type hemorrhoid artery ligation hemorrhoid suspension operation positioning device and application thereof. The device comprises an outer sleeve and an inner sleeve, the inner sleeve is movably and / or rotatably arranged in a cavity of the outer sleeve, the outer sleeve is provided with an outer sleeve operation window, the inner sleeve is provided with an inner sleeve operation window, and the outer sleeve operation window and the inner sleeve operation window can be moved or rotated. The outer sleeve operating window and the inner sleeve operating window are at least partially aligned with each other at at least one operating window position; the outer sleeve and the inner sleeve longitudinally extend to at least partially form a cylindrical or conical or truncated cone-shaped structure, the outer sleeve forms a tubular shell main body and a shell split body along the longitudinal extension direction, and the side edges of the tubular shell main body and the shell split body are detachably connected; an optical unit is arranged on the shell split body so as to irradiate the cavity of the outer sleeve.

The invention relates to the technical field of medical monitoring and intelligent decision making, and particularly discloses an intraoperative noninvasive real-time blood flow monitoring and medication intervention analysis system. Pulse wave oscillation harmonic component characteristics and diastolic attenuation characteristic characteristics are extracted by using variational mode decomposition and a polynomial fitting algorithm; the multi-dimensional features are fused and then input into a deep learning classification model, and accurate recognition of insufficient heart pump efficiency, abnormal peripheral vascular tension and circulation capacity imbalance states is achieved; time sequence prediction and grading early warning are carried out based on the hidden Markov model and the individualized baseline safety interval, and finally a targeted medication scheme is output through the intervention strategy knowledge base.

The invention relates to the field of physiological signal detection, and discloses a blood pressure measurement system based on brachial artery cuff pressurization and finger PPG detection, which comprises a pressure control module, a PPG acquisition module and a central processing unit. The central processing unit is configured to extract a multi-dimensional PPG feature vector from the PPG signal in real time; dynamically adjusting the change mode of the cuff pressure applied by the pressure control module in a closed-loop manner based on the change of the PPG feature vector; constructing a dynamic response map based on the synchronously recorded cuff pressure and PPG feature vector; and determining a blood pressure value based on the overall analysis of the dynamic response map. Determining the blood pressure value specifically includes identifying a systematic distorted phase transition point in the atlas to determine systolic pressure. Through closed-loop adaptive excitation and global trajectory analysis, blood pressure determination is established on the basis of hemodynamic state transition, dependence on isolated event points is avoided, and measurement robustness and accuracy are improved.

The invention discloses an artery plaque detection and evaluation method and device, and relates to the technical field of image recognition. The method comprises the following steps: acquiring a to-be-used image group, wherein the to-be-used image group comprises at least one modal magnetic resonance image; performing blood vessel wall segmentation operation on the to-be-used image group to obtain a binary blood vessel skeleton image; inputting the to-be-used image group and the binarized vascular skeleton image into a trained plaque segmentation model to obtain a binarized plaque mask combination; inputting the binarized plaque mask combination and the to-be-used image group into a trained plaque component recognition model to obtain a multi-label segmentation result image; and performing plaque vulnerability judgment according to the multi-label segmentation result image so as to obtain plaque vulnerability judgment information. According to the method, the problems of high subjectivity, poor generalization ability, sensitivity to image quality and the like caused by dependence on artificial feature extraction and threshold segmentation in a traditional method are solved.

The invention discloses a human body peripheral blood vessel photoacoustic three-dimensional imaging device and an imaging method thereof, and belongs to the field of blood vessel imaging. Through high resolution and functional monitoring capability of photoacoustic imaging, detailed blood vessel structure and blood flow dynamic information are provided, and early recognition and treatment effect evaluation of common lesions such as diabetic foot and peripheral artery diseases are promoted; meanwhile, a mechanical system is adopted, so that the detection front end with relatively high quality can be borne, and stable operation is realized, and a relatively good photoacoustic imaging result is obtained; the system has a highly stable accurate scanning imaging mode, and is convenient for multiple imaging modes of clinical application; through the arrangement of the imaging water tank and the lifting structure of the imaging water tank, switching of imaging modes in a limited space can be ensured, so that the device can be suitable for the layout of a portal type three-dimensional moving device. The system is expected to promote the portability of equipment, reduce the research and development cost of the equipment, be widely applied to clinical practice and community medical treatment, and improve the disease management level.

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

The invention relates to an application of a histone H3K18 lactic acid modification related target in preparation of a medicine for preventing or treating atherosclerosis. The invention belongs to the field of biological medicine, and discloses histone acetyltransferase P300 and application of histone H3K18 lactylation (H3K18la) modification mediated by the histone acetyltransferase P300 as a new target spot for treating atherosclerosis (AS). Researches find that in the AS process, lactic acid accumulation in vascular smooth muscle cells (VSMCs) up-regulates H3K18la through P300 catalysis, and then the pathological phenotype of the VSMCs is induced, and plaque development is promoted. H3K18la can be reduced and the phenotype can be improved by inhibiting LDHA and MCT1 in vitro or knocking out a P300 gene; the P300 for in-vivo targeted inhibition of the VSMCs can significantly reduce the artery plaque. Therefore, the P300 and H3K18la inhibitors can be used for preparing the anti-atherosclerosis medicine.

Some disclosed blood pressure estimation methods involve controlling, by a control system, an ultrasonic sensor system to transmit ultrasonic waves to a target object on an outer surface of an apparatus, the ultrasonic sensor system having M ultrasonic receiver elements in a single array. Some such methods involve receiving, by the control system from the ultrasonic sensor system, ultrasonic receiver signals from each of a plurality of the M ultrasonic receiver elements in the single array, the ultrasonic receiver signals corresponding to ultrasonic waves reflected from the target object. Some such methods involve detecting, by the control system, an artery within the target object based on the ultrasonic receiver signals. Some such methods involve estimating, by the control system, a blood pressure within the artery based on the ultrasonic receiver signals.

The invention relates to the technical field of medical instruments, in particular to a femoral artery hemostasis device and a hemostasis method. Comprising a compression plate and a compression ball installed on the upper side of the compression plate, a first compression point is arranged in the center area of the top of the outer surface of the compression ball, an annular center mark is arranged on the top of the inner surface of the compression ball, and a plurality of second compression points are arranged on the outer surface of the compression ball and located below the first compression point at equal intervals in the circumferential direction. The inner surface of the compression ball is provided with an annular guide line used for marking second compression points, and the inner surface of the compression ball is further provided with a radial guide line with one end connected with the corresponding positions of the second compression points on the annular guide line and the other end pointing to the center mark. The privacy protection device further comprises a fixing adhesive tape, and a privacy curtain used for shielding privacy is arranged on the fixing adhesive tape. The hemostasis device is simple in structure and convenient to use, operation procedures are reduced, the adaptability of the ellipsoidal curved surface structure is good, the hemostasis efficiency is greatly improved, and the hemostasis effect is more remarkable.

The invention discloses an atherosclerotic plaque risk assessment method and system based on artificial intelligence, relates to the technical field of medical image analysis, and provides the following scheme: synchronously acquiring medical image sequence and physiological signal time sequence data, generating a synchronization data set through time-space registration, and performing time-space registration on the synchronization data set; and inputting the synchronized data set into a pre-trained LSTM neural network, and outputting a dynamic artifact offset field which represents a displacement vector of a medical image pixel point along with a physiological signal phase. Gradient amplitude analysis is performed on the medical image sequence frame by frame to generate the gradient characteristic evolution graph, high, medium and low response areas are divided according to the dynamic gradient threshold interval, and the displacement correction vectors are configured for the areas, so that the problem of gradient response heterogeneity compensation deficiency in a conventional correction strategy is solved, adaptive deformation correction of an anatomical structure is realized, and the correction accuracy is improved. And low-gradient region structure dispersion and vascular wall edge sharpness attenuation caused by global compensation are inhibited.

Some embodiments of a rotational atherectomy and lithotripsy system can partially or completely remove a stenotic lesion in blood vessels by rotating one or more abrasive elements to abrade and breakdown the lesion, by emitting acoustic energy to fracture and breakdown the lesion, or a combination of both.

The invention belongs to the technical field of DSA, and discloses a DSA platform-based multi-state real-time multi-mode image accurate fusion method. After an angiography image is collected on the basis of DSA equipment under the motion condition, accurate DSA blood vessel subtraction image enhanced display is achieved, meanwhile, hepatic artery extraction in a three-dimensional image in preoperative CT is completed, dynamic intelligent fusion of a precise anatomical structure in a preoperative multi-mode CT image and intraoperative local blood vessel development is combined, and the dynamic and intelligent fusion of the dynamic and intelligent fusion of the dynamic and intelligent fusion of the dynamic and intelligent fusion of the dynamic and intelligent fusion of the dynamic and intelligent fusion of the dynamic and intelligent fusion of the dynamic and intelligent fusion is achieved. The intrahepatic lesions and important blood vessels are accurately and visually displayed, operation planning is completed, fusion of three-dimensional information and two-dimensional DSA is utilized, and transvascular and percutaneous interventional operations are accurately guided.

Some embodiments of a rotational atherectomy device can remove (partially or completely) stenotic lesions in blood vessels by rotating one or more abrasive elements in an orbital path to abrade and breakdown the lesion. In particular implementations, multiple abrasive elements are arranged along a distal portion of a drive shaft with an improved configuration so as to facilitate both efficient navigation into vessels extending from the abdominal aorta such as the common iliac artery, the external iliac artery, the internal iliac artery, the profunda artery, the gluteal artery, and the pudental artery and effective orbital paths for abrading stenotic material in such vessels and junctions between such vessels.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

A multi-mode early-stage cancer postoperative survival and recurrence time prediction method comprises the following steps: firstly, aligning four-phase CT (Computed Tomography) images of a plain scanning phase, an arterial phase, a venous phase and a delayed phase, and respectively carrying out spatial feature extraction and time sequence splicing processing on the four-phase CT images by utilizing a mixed model structure of a 3D CNN (Three-Dimensional Convolutional Neural Network) and a time sequence model; clinical data are projected through a multi-layer perceptron (MLP) formed by a full connection layer, then the data are fused through a cross attention mechanism, clinical features serve as Query, image features V serve as keys (Key) and values (Value) at the same time, and the recurrence time (RFS) and the survival time (OS) in the early stage of a cancer operation are predicted. According to the method, the accuracy is greatly improved by combining spatial information and time sequence information prediction, and meanwhile, the decision-making process is more interpretable by using priori medical knowledge as guidance.

The invention provides a single-needle hemodialysis blood pipeline device which comprises a piston type container, a liftable piston plate is connected to the interior of the piston type container through a first elastic piece, an artery pot and a vein pot are arranged on one side of the piston type container and communicate with each other through a three-way pipeline, one end of the first pipeline communicates with the artery pot through a first valve, and the other end of the first pipeline communicates with the vein pot through a second valve. The blood pump is communicated with a dialyzer, one end of the dialyzer is communicated with a pipeline II, and the pipeline II is communicated with the vein pot through a valve II; the pipeline III is communicated with the pipeline I and the piston type container and is provided with a valve III; the fourth pipeline is communicated with the second pipeline and the piston type container and provided with a fourth valve, and the piston type container is further provided with a switching mechanism. According to the device, blood can be fully dialyzed only through single-needle puncture, it is ensured that the blood in the dialyzer makes full contact with the dialyzer, the toxin removing efficiency is improved, and finally full dialysis in a special scene is achieved.

The application provides an MR arteriovenous double-mode blood vessel puncture navigation system and method, which combines multispectral near-infrared imaging, real-time biomechanical simulation and virtual-real fusion display and the like to create a novel blood vessel puncture navigation architecture, can directly present the position and direction of subcutaneous veins and arteries, and can update the display in real time along with the movement or tissue deformation of a patient, and can display the dynamically adjusted three-dimensional position of blood vessels in real time, overcomes the defects of incomplete blood vessel positioning and poor dynamic adaptability in the prior art, and can provide accurate and intuitive navigation, can promote efficient and accurate blood vessel puncture, and effectively reduces the risk.

The invention discloses a construction method and application of a preeclampsia animal model based on an RASA3 target, and belongs to the technical field of biomedicine.The preeclampsia animal model is constructed by injecting Ad-RASA3 into a pregnant mouse and monitoring pathological indexes, related to preeclampsia, of the pregnant mouse. According to the method, the animal model with preeclampsia-like clinical symptoms can be stably induced, the abnormal change of the uterine spiral artery remodeling process can be systematically monitored, the method is high in operation controllability and model stability, and an effective tool can be provided for deeply researching the pathogenesis of preeclampsia and developing a novel diagnosis and treatment strategy.

The invention relates to the technical field of intracranial pressure monitoring, in particular to a multi-modal fusion-based intracranial pressure dynamic prediction method for a patient with craniocerebral injury, which comprises the following steps of: acquiring an electroencephalogram signal, extracting a peak value to a termination section path, judging whether a waveform slope is consistent with an intracranial pressure direction or not, identifying an unsynchronized response segment, and obtaining a neural migration section mark set. According to the method, the non-cooperative state between the neural activity and the pressure change is distinguished by recognizing the periodic waveform which does not cause the intracranial pressure response in the electroencephalogram signal, and the time period with the inconsistent regulation rhythm is positioned by combining the continuous expression of the ventricular volume and the arterial pressure direction deviation; the method comprises the following steps of: extracting response sequence and direction characteristics of arterial pressure, cerebral blood flow and neural signals in a continuous section, enhancing a rhythm corresponding relation among multi-modal signals, adjusting a signal alignment structure according to offset direction difference and a rhythm starting point, forming a linkage fragment sequence under a unified time reference, and obtaining a multi-modal signal sequence; and linkage and deduction of asynchronous response information on a structural level are promoted.

The invention discloses a preparation method of vascular tissue-derived extracellular vesicles, and belongs to the field of cytobiology. According to the preparation method of the extracellular vesicles, the artery blood vessel tissue is directly subjected to enzymolysis through collagenase, the extracellular vesicles are obtained by combining low-speed centrifugation and ultra-speed centrifugation methods and utilizing a differential centrifugation mode, and the technical blank of obtaining the extracellular vesicles from the blood vessel tissue is filled. Experimental results show that the extracellular vesicles can be successfully prepared from collagenase I, collagenase II, collagenase IV, collagenase V or collagenase IV combined with elastin, the prepared extracellular vesicles are different in particle size, form, yield, protein quantity, purity and the like, and the quality of the extracellular vesicles obtained by enzymolysis of collagenase IV combined with elastin is optimal. The extracellular vesicles are extracted from vascular tissues with normal physiological characteristics for the first time, a new source is provided for preparation of the extracellular vesicles, and the extracellular vesicles have great significance in expanding application of the extracellular vesicles.

The invention discloses a vein blood oxygen saturation real-time measurement system and method based on an LED light source. The method comprises the steps that 1, a pulse driving circuit outputs pulse voltage to drive LEDs with different wavelengths in a dual-wavelength LED light source to flicker alternately; collecting a photoacoustic signal by an ultrasonic transducer; 2, the ultrasonic signal processing platform receives the collected sound signals and carries out subsequent processing; 3, controlling the ultrasonic transducer to transmit an ultrasonic signal to the same measured part, and receiving an echo signal of the ultrasonic transducer; reconstructing an ultrasonic image of the measured part based on the echo signal; step 4, in the obtained ultrasonic image, positioning a vein to be analyzed and an adjacent artery thereof, and positioning the vein in the ultrasonic image; 5, the arterial oxygen saturation value of the whole body is measured through a finger clamping type pulse oximeter, and quantitative calculation of the venous oxygen saturation is achieved; and step 6, carrying out pixel-level fusion on the oxyhemoglobin saturation information and the ultrasonic image, and realizing visualization on the same frame of ultrasonic image.

Some disclosed examples involve controlling, by a control system of an apparatus, a light source system of the apparatus to provide light to a target object on an outer surface of the apparatus and receiving, by the control system, ultrasonic receiver signals from each of a plurality of M ultrasonic receiver elements in a single array, the ultrasonic receiver signals corresponding to ultrasonic waves generated by the target object responsive to the light. Some disclosed examples involve detecting, by the control system, an artery within the target object based on the ultrasonic receiver signals and estimating, by the control system, a blood pressure within the artery based on the ultrasonic receiver signals.

The invention relates to the technical field of blood purification, and particularly discloses an integrated blood purification pipeline consumable device which comprises a main body bracket, and an artery pipeline assembly, a dialysis filter, a vein pipeline assembly, a pre-flushing piston assembly, a liquid inlet tank assembly and a liquid outlet tank assembly which are mounted on the main body bracket. The key core problem solved by the invention is to integrate treatment consumable pipelines and integrate a plurality of auxiliary function modules, so that the operation convenience of medical staff is greatly improved on the premise of ensuring treatment; by configuring an automatic pre-flushing function, a heparin injection function, a quantitative system and the like, the operation process of ultralight portable blood purification equipment matched with the device can be simplified, the size and the weight of the equipment are reduced, and the equipment is suitable for wider and more complex application environments; the method can be used for early treatment of severe wounded persons in modern wars, emergency supplement of conventional dialysis treatment patients, disaster relief without traditional dialysis conditions, self-treatment of patients in emergencies and the like, and has wide application prospect and practical value.

An image processing method performed by a processor includes: a step of acquiring a fundus image in which choroid blood vessels are visualized; a step of extracting choroid arteries in the fundus image acquired in the acquiring step by performing image processing on the fundus image; and a step of generating a fundus image in which the choroid arteries extracted in the extracting step are highlighted.

The invention provides a dynamic bionic robot skin, a control method thereof and a robot. The dynamic bionic robot skin is characterized in that a bionic blood vessel network channel is arranged in a dynamic bionic layer; the bionic blood vessel network channel is used for simulating dynamic changes of blood vessels; the bionic blood vessel network channel is an elastic cavity embedded into the dynamic bionic layer; the dynamic blood vessel regulation module is communicated with the bionic blood vessel network through a pipeline, and the dynamic blood vessel regulation module is used for changing the filling degree and / or form of the bionic blood vessel network channel by pumping a fluid medium into and out of the blood vessel network channel or adjusting the internal pressure; the light-transmitting bionic epidermal layer covers the outer surface of the dynamic bionic layer and is fixedly connected with the dynamic bionic layer, and bionic skin textures are arranged on the outer surface of the light-transmitting bionic epidermal layer. The invention further discloses a robot and a skin control method. The method is high in simulation degree, and physiological phenomena such as blood vessel filling contraction and artery rhythm can be achieved.

The invention provides an application of a super enhancer inhibitor JQ-1 in preparation of peripheral artery disease related drugs, relates to the technical field of biomedicine, and discloses a core effect of the super enhancer inhibitor JQ-1 in peripheral artery disease ischemia repair. The traditional Chinese medicine composition can significantly accelerate blood flow recovery of ischemic limbs, up-regulate mRNA and protein expression of a vascular marker CD31 in gastrocnemius muscle tissues, effectively increase vascular density and promote angiogenesis. Aiming at the defects of the existing treatment means in the aspect of ischemic tissue angiogenesis, the application provides a brand new molecular targeted treatment scheme for high-risk groups such as patients with diabetes-related peripheral artery diseases, and can significantly reduce the risk of lower limb amputation and the incidence rate of related cardiovascular adverse events such as coronary heart disease and stroke; the technical blank of specific targeted therapy of peripheral artery diseases is filled, a solid scientific basis and a key direction are provided for research and development of novel drugs, and the specific targeted therapy method has extremely high clinical application value and wide research and development prospects.

Some embodiments of a rotational atherectomy device can remove (partially or completely) stenotic lesions in blood vessels by rotating one or more abrasive elements in an orbital path to abrade and breakdown the lesion. In particular implementations, multiple abrasive elements are arranged along a distal portion of a drive shaft with an improved configuration so as to facilitate both efficient navigation into smaller blood vessels below the ankle or in the heart and effective orbital paths for abrading stenotic material in such smaller vessels.