76 results about "Oxygenated Hemoglobin" patented technology

The invention relates to methods and devices for measuring pulsus paradoxus. The methods herein employ a combination of one or more forms of waveform analysis for the purpose of measuring pulsus paradoxus and diagnosing respiratory distress. The methods also combine measurements of pulsus paradoxus and physician assessments to diagnose respiratory distress. The methods also combine measurements of pulsus paradoxus and percentage oxygenated hemoglobin to diagnose respiratory distress. The devices of this invention employ pulse oximeters, arterial tonometers, finometers, or processors for the purpose of implementing the methods of the invention.

The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.

Methods and apparatus are provided for detecting an abnormality in a host medium, such as a tumor within a patient's breast. The host medium is initially illuminated at a plurality of different positions with light of at least two different wavelengths. Following the propagation of the signals through the host medium, the amplitude and phase of the signals are detected and, based upon the detected signals, a shadow image can be created in which the abnormality is depicted as a suspicious region. Once a suspicious region has been identified, at least that portion of the host medium that contains the suspicious region is again illuminated with frequency-swept modulated signals of at least two different wavelengths generated by the light source and modulated by a modulator, such as a network analyzer. Based upon the detected signals that have propagated through at least that portion of the host medium that includes the suspicious region, a P-criteria can be determined that is dependent upon the coefficient of absorptivity of the host medium and embedded abnormalities. Likewise, an Svar-criteria can be determined based upon concentrations of oxygenated hemoglobin and deoxygenated hemoglobin. Based upon at least these criteria which reflect physiological parameters of the host medium and embedded abnormalities as well as the possible comparison of the shadow images to an x-ray image of the host medium, the abnormality can be characterized. In addition, an apparatus is provided that facilitates the compression of a patient's breast in order to improve the resulting images.

An improved sensor (102) for physiology monitoring in mobile devices, wearables, security, illumination, photography, and other devices and systems uses broadband light (114) transmitted to a target (125) such as the ear, face, or wrist of a living subject. Some of the scattered light returning from the target to detector (141) is passed through narrowband spectral filter set (155) to produce multiple detector regions, each sensitive to a different wavelength range. Data from the detected light is spectrally analyzed to computationally partition the analyzed data into more than one compartment of different temporal or physiological characteristics (such as arterial bloodstream, venous bloodstream, skin surface, and tissue), and into more than one component compound (such as oxygenated hemoglobin, water, and fat), allowing a measure of physiology of the subject to localized to one compartment, thereby reducing the effects of body motion, body position, and sensor movement that can be localized to other physiological compartments or components. In one example, variations in components of the bloodstream over time such as oxyhemoglobin and water are determined based on the detected light, and localized to remove skin surface scattering and reflection, and to minimize changes in the venous bloodstream caused by impact and motion, resulting in an arterial bloodstream signal with an improved signal to noise for the cardiac arterial pulse. The same sensor can provide identifying features of type or status of a tissue target, such as heart rate or variability, respiratory rate, calories ingested or expended, hydration status, or even confirmation that the tissue is alive. Monitoring devices and systems incorporating the improved sensor, and methods for analysis, are also disclosed.

The present invention provides an apparatus for evaluating biological function that, in differentiating as far as possible information from the capillaries, which reflects tissue metabolism, from information from outside the tissue (for example, the arteries and veins), has high speed and accuracy enabling it to compensate for the low spatial resolution of conventional near infrared spectroscopy methods, and that furthermore does not merely monitor changes in oxygen concentration and the like, but makes it possible to easily and conveniently distinguish between capillary reactions, metabolic reactions and the like; its configuration is characterized in that it provides a light irradiation means for irradiating light to a specified site of a living body, a light detection means for detecting light exiting from the living body, a calculation means for determining the respective changes in concentration of oxygenated hemoglobin and deoxygenated hemoglobin by performing calculations in near infrared spectroscopy with the intensity of the detected light as a parameter, and a display means for displaying information concerning the relative ratio “k” between both these data over time.

A physiologically ingestible composition of matter obtained by using super-oxygenated and structured water, and uses thereof are provided. The tuned super-oxygenated and structured water is produced by receiving oxygen enriched water into a coil system and passing the water therethrough, combining water output by the coil system with structured ozone, inputting the combined water and structured ozone to a multicoil system and passing the water therethrough, and outputting tuned super-oxygenated and structured water. The tuned super-oxygenated and structured water may also be utilized for producing and tuning super-oxygenated and structured water. The physiologically ingestible composition of matter may be administered to increase the level of oxygenated hemoglobin in the blood of a mammal.

A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin.

Apparatus for monitoring oxygen saturation levels in tissue for a miniature wireless disposable optical tissue oximeter to are disclosed. According to one aspect of the present invention, a sensor contains a first light source, a second light source, a photodetector, and a skin contact detector. Once skin contact is detected, the first light source emits light in the near infrared region, and the second light source emits light in the visible red region. The emitted light passes through a transparent layer of an adhesive fixation unit, and enters the underlying tissue, where a portion of the light is absorbed by tissue chromophores, including oxygenated hemoglobin and deoxygenated hemoglobin, and reflected back out of the tissue into the photodetector. The oxygen saturation of the tissue under the sensor is then calculated. The oxygen saturation measurements are wirelessly transmitted to a remote display device, such as a smartphone running a smartphone software application which receives the measurements and displays them in numeric, graphical, and audible form. In addition, the smartphone software application may relay the data to the Internet for remote viewing on a web site or remote transfer to a hospital patient data system.

A low cost portable high speed quantitative system for diffuse optical spectroscopic imaging of human tissue. The hybrid system (CWFD) can measure absolute optical properties from 660 nm to 980 nm and recover all tissue chromophore concentrations. The standalone FD module can be utilized to measure scattering at every measurement and recover deoxygenated and oxygenated hemoglobin concentrations. The CW module can operate concurrently with the FD module to also measure water and lipid. The high temporal resolution and large signal-to-noise ratio of the CWFD system may be used to explore tissue oximetry, vascular occlusion, and paced breathing models to measure and analyze tissue hemodynamics response to changes in blood flow. Continuous monitoring of vasculature response to various modified blood perfusion conditions can provide information about local tissue metabolism and physiological state (dysfunction).

A physiologically ingestible composition of matter obtained by preparing water with a negative oxidation reduction potential (ORP), and the uses thereof, are provided. The obtaining method includes preconditioning water received from a water source for electrolysis, performing electrolysis on the preconditioned water, and outputting alkaline water and / or acidic water with a negative ORP. The output alkaline water and / or acidic water with a negative ORP may be used for a variety of purposes and / or applications. For example, the method may be utilized as part of a method for producing and tuning super-oxygenated and structured water. The physiologically ingestible composition of matter may be administered to increase the level of oxygenated hemoglobin in the blood of a mammal.

A method of delivering oxygen to a tissue, a blood vessel, an organ, or a region of an organ, under an ischemic condition, or prophylactically preventing occurrence of an ischemic condition, of a subject, comprising the step of administering to the subject an oxygenated hemoglobin solution, wherein the oxygenated hemoglobin solution includes polymerized hemoglobin, and wherein about 80% by weight, or greater, of the polymerized hemoglobin is oxyhemoglobin.

The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.

The invention relates to an upper limb movement imagination pattern recognition based on multi-modal signals. At first, the movement imagination pattern recognition based on multi-modal signals calculates the original near infrared spectrum signal to obtain the oxygenated hemoglobin content in the brain, and extract the CSP characteristic from the oxygenated hemoglobin content value; secondly, thesample entropy is extracted from the EEG signal; then, the obtained multimodal features are normalized and serially fused; and finally, the support vector machine model is used to classify the fusedmulti-modal features. The movement imagination pattern recognition based on multi-modal signals has the advantages of maintaining high spatial resolution of the electroencephalogram signal, and supplementing the characteristics of high temporal resolution of the near-infrared spectrum signal at the same time, so that the recognition rate of the upper limb movement imagination mode is improved.

The mental state, such as mood or emotion, of an individual can be apprehended by a method using non-invasive biological light measurement technology. A biological light measurement device, which has an irradiation section, presents different tasks (at least a first task and a second task) to a subject, hemoglobin signals based on changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin in the subject are calculated from the strength of light detected by a detection section, and a relative value using the hemoglobin signal at a predetermined measurement channel with respect to the first task, and the hemoglobin signal at a different predetermined measurement channel with respect to the second task is calculated.

An oxygenated Hemoglobin (Hb) solution includes from about 10 g to about 250 g of polymerized Hb per liter of solution. About 80% by weight, or greater, of the polymerized Hb of the oxygenated hemoglobin solution is oxyhemoglobin. About 18% by weight, or less, of the polymerized Hb has a molecular weight of over 500,000 Daltons. About 5% by weight, or less, of the polymerized Hb has a molecular weight equal to or less than 65,000 Daltons. A P50 of the polymerized Hb is in a range of between about 34 and about 46 mm Hg. An endotoxin content of the oxygenated Hb solution is less than about 0.05 endotoxin units per mL. A method of visualizing a tissue or organ of a subject includes the steps of administering to the subject an oxygenated hemoglobin solution as described above, and imaging the tissue, blood vessel or organ with an imaging system. A method of producing an oxygenated Hb solution includes the step of oxygenating a Hb solution that includes polymerized Hb as described above to thereby cause about 80% by weight, or greater, of the polymerized Hb to become oxyhemoglobin.

The present invention provides oxygenated hemoglobins in powdered form and methods of preparing a powdered form of a protein, such as hemoglobin, which comprise (a) mixing a solution of the protein with inulin, and optimally with a reducing sugar such as glucose or tagatose, and (b) drying the mixture. Also provided are blood substitutes formed from reconstituted powdered hemoglobins, and methods of treatment using the blood substitutes.

The invention discloses a device for measuring oxygenated hemoglobin and deoxygenated hemoglobin and a near infrared brain imaging device. The device comprises an interface module, a near infrared receiving and transmitting module and a controller, wherein the near infrared transceiving module is provided with a plug-and-play interface and plugged in the interface module through the plug-and-playinterface, the near infrared receiving and transmitting module is driven by the controller to transmit preset-wavelength near infrared rays to measured cerebral cortex and receive light intensity signals generated when the near infrared rays are reflected by the measured cerebral cortex. The controller is connected with the interface module and used for receiving the light intensity signals outputby the near infrared receiving and transmitting module and measuring parameters of oxygenated hemoglobin and deoxygenated hemoglobin of the measured cerebral cortex according to the light intensity signals. Thus, according to the characteristic that hot plug is supported by the near infrared receiving and transmitting module, the aims of increasing and decreasing functions and channel number canbe realized, and the reusability of the device and the usage rate of parts can be increased.

In the special observation mode, second illumination light including different-absorption-wavelength light that has different absorption coefficients for oxygenated hemoglobin and reduced hemoglobin is emitted, a turn-off state is thereafter initiated, and signal reading is performed for some of a plurality of pixel rows in accordance with a skip read method. Subsequently, first illumination light, which is normal light, is emitted, a turn-off state is thereafter initiated, and signal reading is performed for all of the pixel rows in a column direction in accordance with a pixel addition read method. An image processor generates an oxygen saturation image on the basis of a second image capture signal read in accordance with the skip read method and a first image capture signal read in accordance with the pixel addition read method, and generates a normal observation image on the basis of the first image capture signal.

The present invention provides systems, devices, and methods to vaporize prostatic tissue having oxygenated hemoglobin. The systems, devices, and methods include a laser module configured to emit light near an absorption peak of the oxygenated hemoglobin and a delivery catheter that is optically coupled to the laser module and configured to deliver the light from the laser module to the prostatic tissue.

PPG is photo plethyamo graphy, which is characterized in that LED light is emitted to skin, a photosensitive sensor is used for receiving the light reflected from the skin tissue after being absorbedby the skin tissue or transmitting the skin, and the electric signal obtained by the photosensitive sensor is converted into a digital signal so as to obtain the final PPG signal. Due to the differentabsorption characteristics of oxygenated hemoglobin and hemoglobin, a prior method uses light with two wavelengths to respectively measure the intensity of the reflected light alternating current signal, and then calculates the proportion of the oxygenated hemoglobin and hemoglobin according to the absorption characteristic diagram of the two beams of light. The invention provides a device for measuring the heart rate and the blood oxygen saturation based on depth learning and PPG signals, which is used for obtaining two paths of PPG signals by using two beams of light, and meanwhile, the PPGsignals are processed through a depth learning network model in the device, thereby predicting the heart rate and blood oxygen saturation of a human body. The device has good tolerance to noise, andcan accurately measure the heart rate and the blood oxygen in a resting state or a motion state.

The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.

A method for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes to organs and peripheral tissues in human bodies is disclosed by administering a compound of phthalides to a subject in need thereof to improve the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes to the organs and the peripheral tissues in human bodies. The compound of phthalides is characterized by a phthalide functional group, and forms at least one hydrogen bond with [alpha]Arg141 of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes, stabilizing the [alpha]1 / [alpha]2 interface of hemoglobin, further stabilizing the oxygenated hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes in the low oxygen affinity 'T' state and facilitating the oxygen release to the organs and the peripheral tissues. A medication for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin, and hemoglobin-based blood substitutes to organs and peripheral tissues in human bodies is also disclosed.

The invention relates to a device for quantitatively detecting the spectral content distribution of oxygenated hemoglobin and deoxygenated hemoglobin. The device comprises a light source module, an imaging module, an adjusting bracket, an image data transmission link, a control command transmission link and a computer. As a technical means of high spectral imaging is adopted, the full cover detection is realized in a detected region, and a characteristic spectrum of the oxygenated hemoglobin and the deoxygenated hemoglobin is extracted through using a spectral decomposition technology, the calculation is carried out by utilizing a regional oxygen saturation computational formula, and the device and the method have the characteristics of acquiring comprehensive information and being high in precision without any reagent.

Exemplary embodiments of the present disclosure provide method and apparatus for providing electromagnetic radiation to a biological tissue that may be selectively absorbed by venous structures as compared to arteries. For example, a wavelength of the electromagnetic radiation can be selected based on absorptivity of the radiation by oxygenated hemoglobin, deoxygenated hemoglobin, and / or met-hemoglobin. The wavelength can be, e.g., between about 685 nm and about 705 nm, or between about 690 nm and about 700 nm, or about 694 nm. The exemplary methods and apparatus can be used, e.g., for photothermolysis treatment of venous structures such as port wine stains or varicose veins, while reducing or avoiding undesirable damage to nearby arteries in the irradiated tissue.

A physiologically ingestible composition of matter obtained by using tuned super-oxygenated and structured water having multiple attributes, and uses thereof are provided. The tuned super-oxygenated and structured water is produced by receiving oxygen enriched water into a coil system and passing the water therethrough, combining water output by the coil system with structured ozone, inputting the combined water and structured ozone to a multicoil system and passing the water therethrough, and outputting tuned super-oxygenated and structured water. The tuned super-oxygenated and structured water may also be utilized for producing and tuning super-oxygenated and structured water. The physiologically ingestible composition of matter may be administered to increase the level of oxygenated hemoglobin in the blood of a mammal.

A biological photometric device includes a light irradiating unit for irradiating an object to be examined with light having a predetermined wavelength and sympathizing with oxygenated hemoglobin and deoxygenated hemoglobin through an optical fiber, a light detecting unit for detecting and amplifying light passing through a detecting optical fiber and the object as detected signals, a signal processing unit adapted for computing hemoglobin time change information based on oxygenated hemoglobin, deoxygenated hemoglobin and total hemoglobin in the object from the detected signals light detecting unit, and including a noise detector for arithmetically processing the detected signals and determining / detecting whether the time change information is noise attributed to the presence of obstacles to passing of light between the object and the end face of the optical fiber or noise attributed to the damage to the light irradiating unit, and a display unit for displaying the noise signals.