20 results about "Oxygenated Hemoglobin" patented technology

The invention relates to the technical field of neurological rehabilitation, in particular to a transcranial direct current closed-loop regulation and control method based on near-infrared brain oxygen real-time feedback, which comprises the following steps: collecting brain oxygen baseline signals of each region of the whole brain, calculating the mean value and the standard deviation of each brain region, and establishing a whole brain blood oxygen regulation and control threshold matrix of sub-regions and sub-parameters; dynamically adjusting the core target brain region, and adjusting the sampling frequency and the single detection duration according to the fluctuation frequency of the oxyhemoglobin concentration of the core target brain region; according to the signal fluctuation frequency, continuously adapting the detection parameters, and combining the comparison result of the core characteristic parameters and the whole brain blood oxygen regulation threshold matrix, optimizing the transcranial direct current regulation parameters, and outputting optimized data; by means of the mode, dynamic adaptation of the detection parameters and the signal fluctuation characteristics is carried out, and regulation and control collaboration is improved.

To provide a blood sugar level measuring device and a blood sugar level measuring method capable of accurately measuring a blood sugar level of a living body.SOLUTION: A blood sugar level measuring device 1 includes: a light output unit 3 that outputs measurement light L to a living body 6; a light detection unit 4 that detects the measurement light L transmitted through the living body 6; a temporal phase difference calculation unit that calculates a temporal phase difference between an oxygenated hemoglobin waveform related to an oxygenated hemoglobin concentration of blood of the living body 6 and a deoxygenated hemoglobin waveform related to a deoxygenated hemoglobin concentration of the blood of the living body 6 based on a result of the detection by the light detection unit 4; a blood sugar level calculation unit that calculates a blood sugar level of the living body 6 based on the temporal phase difference; a similarity estimation unit that estimates a waveform similarity between the oxygenated hemoglobin waveform and the deoxygenated hemoglobin waveform; and a reliability estimation unit that estimates reliability of the blood sugar level. The reliability estimation unit estimates that the reliability of the blood sugar level is lower as the waveform similarity is smaller.SELECTED DRAWING: Figure 1

To provide a blood sugar level measuring device and a blood sugar level measuring method capable of accurately calculating a blood sugar level.SOLUTION: The blood glucose level measurement device 1 includes a light output unit 3 that outputs measurement light L to a living body 6, a light detection unit 4 that detects the measurement light L transmitted through the living body 6, a time phase difference calculation unit 51 that calculates a time phase difference between an oxygenated hemoglobin waveform and a deoxygenated hemoglobin waveform based on a detection result of the light detection unit 4, a blood glucose level calculation unit 52 that calculates a blood glucose level of the living body 6 based on the calculated time phase difference, and a blood glucose level calibration unit 54 that calibrates the blood glucose level calculated by the blood glucose level calculation unit 52. The blood-sugar-level calibrating unit 54 performs calibration such that the blood sugar level calculated by the blood-sugar-level calculating unit 52 during sleep of the living body 6 or in a predetermined period after the living body 6 wakes up from sleep corresponds to a reference blood sugar level set in advance.SELECTED DRAWING: Figure 3

The application discloses a blood oxygen distribution imaging method and system based on double-band diffuse reflection space mapping, relates to the field of non-contact physiological parameter detection for biomedical optical application, and comprises the following steps: acquiring a double-band diffuse reflection original image sequence of a to-be-detected tissue region under two specific bands, obtaining normalized double-band images and a region of interest through preprocessing and region segmentation; estimating an effective optical path ratio between the two specific bands based on image gradient information in a local neighborhood of each pixel, and constructing a local optical path correction matrix; according to a double-band reflection attenuation ratio, a corresponding effective optical path ratio, and extinction coefficients of oxygenated hemoglobin and deoxygenated hemoglobin under the two specific bands, a double-band inversion model based on an improved Lambert-Beer law is used to calculate a preliminary blood oxygen saturation, and a two-dimensional blood oxygen saturation distribution map is generated through spatial regularization optimization. Therefore, the spatial representation capability, inversion stability and imaging accuracy of non-contact blood oxygen imaging can be improved.

The invention relates to the technical field of blood oxygen signal acquisition and monitoring, and provides a multi-channel wireless blood oxygen acquisition and monitoring device and a multi-channel wireless blood oxygen acquisition and monitoring method aiming at solving the problems that a wired data transmission mode is adopted to measure a blood oxygen signal in traditional single photoelectric blood oxygen concentration detection and the accuracy of acquired data is poor. A plurality of photoelectric detectors receive LED reflected light of different depths, blood oxygen signals are calculated according to the received reflected light and are output and displayed, the multi-wavelength LEDs avoid interference of melanin, water molecules and other components on the surface layer of the human brain, and the multi-channel photoelectric detectors are used for detecting oxyhemoglobin of different depths of the human brain and the change of the hemoglobin content. Monitoring data are more accurate and suitable for real-time dynamic monitoring of blood oxygen saturation signals and brain oxygen saturation signals of a patient clinically, a wireless transmission function is achieved, blood oxygen saturation of multiple parts such as the brain and fingertips can be monitored in real time, monitoring precision is high, stability is good, wearing is comfortable, and operation is easy and convenient.

An electro-optical device, an apparatus comprising the electro-optical device and a method of conducting functional near-infrared spectroscopy analysis using such an apparatus. The electro-optical device comprises: a light source arranged to irradiate a target spot of the head of a subject with light emission including a plurality of light components having distinct wavelengths, wherein light components with distinct wavelength are arranged to be partially absorbed by hemoglobin in blood passing though the target spot with distinct absorption ratios; and a light sensor arranged to detect light reflection from the target spot, wherein light reflection is adapted to be further processed for determination of relative concentrations of oxygenated hemoglobin and deoxygenated hemoglobin in the target spot based on a change of each of the light components with respective wavelength in the light reflection when compared to the light emission.

To provide a blood sugar level measuring device and a blood sugar level measuring method capable of measuring a blood sugar level with high measurement accuracy and improving the driving time of the blood sugar level measuring device.SOLUTION: The blood glucose level measurement device 1 includes the acquisition unit 62 that acquires the waveform calculation data for calculating the oxygenated hemoglobin waveform and the deoxygenated hemoglobin waveform by outputting light to the living body and detecting the light transmitted through the living body, the phase difference calculation unit 63 that calculates the time phase difference between the oxygenated hemoglobin waveform and the deoxygenated hemoglobin waveform, and the blood glucose level calculation unit 64 that calculates the blood glucose level of the living body based on the time phase difference. The acquiring unit 62 is configured to be able to execute first sampling for acquiring the waveform calculation data at a first sampling rate and second sampling for acquiring the waveform calculation data at a second sampling rate higher than the first sampling rate.SELECTED DRAWING: Figure 2

This blood glucose level measurement device comprises: an acquisition unit that outputs light to a living body and detects the light transmitted through the living body, thereby acquiring waveform calculation data for calculating an oxygenated hemoglobin waveform and a deoxygenated hemoglobin waveform; a phase difference calculation unit that calculates a temporal phase difference between the oxygenated hemoglobin waveform and the deoxygenated hemoglobin waveform; and a blood glucose level calculation unit that calculates the blood glucose level of the living body on the basis of the temporal phase difference. The acquisition unit is configured to be capable of executing first sampling for acquiring the waveform calculation data at a first sampling rate and second sampling for acquiring the waveform calculation data at a second sampling rate higher than the first sampling rate.

This blood glucose level measurement device comprises: a blood glucose level estimation unit that outputs light to a living body, detects light transmitted through the living body, calculates, on the basis of the result of the detection, a temporal phase difference between an oxygenated hemoglobin waveform relating to the oxygenated hemoglobin concentration of the blood in the living body and a deoxygenated hemoglobin waveform relating to the deoxygenated hemoglobin concentration of the blood in the living body, and calculates the blood glucose level of the living body on the basis of the calculated temporal phase difference; and a body movement detection unit that detects a parameter relating to body movement of the living body. In cases where the parameter detected by the body movement detection unit or the variation in the parameter is equal to or below a threshold value, the blood glucose level estimation unit stores the calculated blood glucose level in a storage unit.

The invention discloses a cognitive state evaluation and regulation training integrated system and method for weight loss, and relates to the technical field of brain function regulation, the system monitors the attenuation degree of multiple beams of near-infrared light with the wavelength of 760 nm and 850 nm after the near-infrared light is emitted from the brain so as to calculate the concentration change value of oxyhemoglobin in the frontal parietal lobe area of the brain, and the concentration change value of the oxyhemoglobin in the frontal parietal lobe area of the brain is calculated. And inputting the oxyhemoglobin concentration change value into a long-short-term memory neural network fused with an attention mechanism, outputting a food desire state of an overweight / obesity user when the overweight / obesity user faces food picture stimulation, and further taking the right dorsal-lateral prefrontal lobe as a regulation and control target, and obtaining the food desire state of the overweight / obesity user through an exogenous or endogenous nerve regulation and control mode. The activity level of the brain region is enhanced, and the food desire state of the overweight / obese user is reduced. The diet control ability of the overweight user can be remarkably enhanced through multiple regulation and control training, the food desire is reduced, and then the effects of improving the ingestion behavior and reducing weight are achieved.

The present application relates to the technical field of unmanned aerial vehicle control, and particularly relates to an unmanned aerial vehicle control method and system based on EEG and fNIRS multi-modal feature fusion, comprising: synchronously acquiring scalp EEG and near-infrared blood oxygen signals, extracting EEG frequency band power spectrum density to construct a fast variable feature matrix, extracting oxygenated hemoglobin concentration change time series features to construct a slow variable feature matrix, and using a phase space reconstruction algorithm to compensate for the slow variable timestamp to achieve alignment; then taking the aligned slow variable as a query matrix, the fast variable as a key matrix and a value matrix, and obtaining a fusion feature matrix through attention mechanism fusion; inputting the fusion feature matrix into a double-branch network to respectively decode discrete instructions and continuous variables, splicing to generate an intention decoding instruction; finally, integrating the concentration change amount to obtain a cognitive load index, and dynamically allocating the weights of the intention decoding instruction and the bottom layer autonomous safety control law according to the cognitive load index to generate a final instruction for execution. The present application solves the problems of low control dimension and easy loss of control and crash.

The present invention is an in vivo non-invasive method and apparatus for the measurement of the arterial blood oxygen saturation status of a patient, the method is a generalized improvement on conventional pulse oximetry to correct for its skin pigmentation bias and significant errors in oxygen saturation assessment in the presence of methemoglobin. The method requires an additional red light sensor with an infrared long pass filter to conventional pulse oximetry, and utilizes red and infrared light and sensors to non-invasively measure the peripheral pulse optical plethysmograph waveforms (PPG) at three light wavelengths, red, long pass red and infrared, positioned over a finger, or ear or other extremity, and from the pulse oximetric ratio of ratios transforms the PPG measurements by a processing device that determines the subject's arterial blood oxygen saturation directly, without the need for an empirical correction as is required in conventional pulse oximetry. The method determines the red transmitted light waveform and thus quantifies the wavelength shift from the incident red light due to the subject's skin pigmentation, and from in vivo hemoglobin extinction coefficients, determines the relative concentrations of oxygenated and deoxygenated hemoglobin and methemoglobin in the subject's arterial blood.

The invention provides a work load assessment method, device, equipment and medium, and the method comprises the steps: collecting the multi-modal physiological data of a work user in the task execution process of the work user, the multi-modal physiological data including electrocardiogram data, human body temperature and the oxyhemoglobin concentration of cerebral cortex; extracting physiological signal features in each mode from the multi-mode physiological data; and inputting the physiological signal features in each mode into a pre-trained work load classification model to obtain a classification result output by the work load classification model, the classification result being used for indicating the work load level of the work user. In this way, by collecting the multi-modal physiological data of the operation user, the comprehensiveness and accuracy of operation load evaluation are improved, the operation load level of the operation user is obtained through the operation load classification model, targeted analysis of the operation user is achieved, the accuracy of operation load evaluation is improved, and the user experience is improved. Therefore, operation distribution can be guided more scientifically and effectively.

An input interface is configured to receive a signal corresponding to a quantity of light that has passed through a living tissue of a subject. A pressurization controller is configured to control a pressurizing operation performed with a pressurization device attached to a body of the subject, thereby changing at least one of a thickness of the living tissue, an amount of blood contained in the living tissue, an amount of cellular interstitial fluid contained in the living tissue, an amount of blood flowing into the living tissue, and an amount of blood flowing out from the living tissue. A processor is configured to acquire, from a temporal change of the signal due to the pressurizing operation, a feature quantity that is used for estimating at least one of a physiological state of the living tissue and a disease state of the subject. An output interface is configured to output a signal corresponding to the feature quantity. The light includes first infrared light for which for which a difference between the absorbance of oxygenated hemoglobin in blood and absorbance of deoxygenated hemoglobin is less than a prescribed value; and second infrared light for which absorbance of water is more than absorbance of hemoglobin.

This blood glucose level measurement device comprises: a light output unit that outputs light; a light detection unit that detects light that has been output by the light output unit and passed through a living body; a temporal phase difference calculation unit that, on the basis of the detection result of the light detection unit, calculates the temporal phase difference between an oxygenated hemoglobin waveform pertaining to the oxygenated hemoglobin concentration of the blood of the living body and a deoxygenated hemoglobin waveform pertaining to the deoxygenated hemoglobin concentration of the blood of the living body; a blood glucose level calculation unit that calculates the blood glucose level of the living body on the basis of the calculated temporal phase difference; a level of similarity estimation unit that estimates the level of waveform similarity between the oxygenated hemoglobin waveform and the deoxygenated hemoglobin waveform; and a reliability estimation unit that estimates the reliability of the calculated blood glucose level. The reliability estimation unit estimates that the reliability becomes smaller as the level of waveform similarity becomes smaller.

The application discloses a non-suicidal self-injury state detection and recognition method based on fNIRS, and relates to the technical field of medical detection and neural imaging; comprising the following steps: S1: using an fNIRS device to collect blood flow hemodynamic data of a subject's prefrontal cortex under a cognitive task, wherein the fNIRS device comprises a light source, a detector and a signal processing unit; S2: pre-processing the collected optical density data, including motion artifact correction, band-pass filtering and baseline correction, to obtain a time series of oxygenated hemoglobin HbO concentration changes; the application provides objective neural activation data through fNIRS technology, effectively reducing subjective bias; through channel-level analysis, six significant difference channels are recognized, and the activation patterns of these channels present a gradient trend of MDD> healthy control > NSSI + MDD, thereby providing a quantifiable biomarker for the NSSI state.

This blood glucose level measurement device comprises: a light output unit; a light detection unit that detects light output by the light output unit and transmitted through a living body; a temporal phase difference calculation unit that calculates the temporal phase difference between an oxygenated hemoglobin waveform and a deoxygenated hemoglobin waveform on the basis of the detection result from the light detection unit; a blood glucose level calculation unit that calculates the blood glucose level of the living body on the basis of the temporal phase difference calculated by the temporal phase difference calculation unit; and a blood glucose level calibration unit that calibrates the blood glucose level calculated by the blood glucose level calculation unit. The blood glucose level calibration unit carries out the calibration such that the blood glucose level calculated by the blood glucose level calculation unit during sleep of the living body or during a prescribed period or time after waking up from the sleep corresponds to a preset reference blood glucose level.

The data processing device (170) is configured to acquire at least one digital input image (130) representing a reflected light image of a biological object (106) and comprising a plurality of input pixels (230, 232). A blood concentration value is determined at an input pixel (230, 232) of the plurality of input pixels (230, 232), the blood concentration value representing a blood volume at a location of the subject (106) imaged in the input pixel (230, 232). Further, a blood oxygenation value is determined at the input pixel (230, 232), the blood oxygenation value representing an amount of deoxygenated hemoglobin and / or an amount of oxygenated hemoglobin at the location of the subject (106). Output pixels (230, 234) of the digital output color image (160) are generated by assigning a color (222) to each output pixel (230, 234), the color (222) depending on the blood oxygenation value and the blood concentration value.

The application relates to the medical imaging field, in particular to an oxygen saturation quantitative imaging device and method for an endoscope, the device comprising a light source part; a shooting part configured to collect reflected light of a target area under light source illumination and output a collected color image and exposure control parameters corresponding to the color image; an image processing part comprising: a spectrum reconstruction module for performing image gain reduction processing on the color image and reconstructing a single waveband image signal of a set wavelength; a light intensity estimation module for calculating light intensity data of the light source respectively; a quantitative calculation module for calculating a light absorption coefficient based on the light intensity data, and solving oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration and oxygen saturation value based on the light absorption coefficient, and generating an oxygen saturation distribution image. The oxygen saturation image generated by the application has rich anatomical structure information and accurate physiological parameter information, and can intuitively display a tissue hypoxic area.

A light emitting device emits: first light including a first wavelength at which an absorbance of oxygenated hemoglobin is larger than an absorbance of deoxygenated hemoglobin; and second light including a second wavelength at which the absorbance of deoxygenated hemoglobin is larger than the absorbance of oxygenated hemoglobin. A light detecting device outputs first and second signals respectively corresponding to intensities of the first and second light that have passed through a living tissue. A processing device acquires: a first difference value between light attenuations of the first and second light based on the signals while compression of the living tissue is performed; and a second difference value between the light attenuations based on the signals after the compression is cancelled. A processing device acquires an index corresponding to an oxygen saturation of blood contained in the living tissue based on a difference between the first and second difference values.