Application of Phthalide compound medication and medication compounds thereof

Abstract

A method for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes to organs and peripheral tissues in human bodies is disclosed by administering a compound of phthalides to a subject in need thereof to improve the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes to the organs and the peripheral tissues in human bodies. The compound of phthalides is characterized by a phthalide functional group, and forms at least one hydrogen bond with [alpha]Arg141 of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes, stabilizing the [alpha]1 / [alpha]2 interface of hemoglobin, further stabilizing the oxygenated hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes in the low oxygen affinity 'T' state and facilitating the oxygen release to the organs and the peripheral tissues. A medication for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin, and hemoglobin-based blood substitutes to organs and peripheral tissues in human bodies is also disclosed.

Description

technical field [0001] The present invention relates to the use of a phthalide compound, in particular to a phthalide compound used to prepare hemoglobin (hemoglobin, Hb for short), hemoglobin variant (hemoglobinvariant), recombinant hemoglobin (recombinanthemoglobin) or hemoglobin-based The use of drugs that release oxygen to various organs and surrounding tissues in the human body. The present invention also relates to a pharmaceutical composition for enhancing the ability of hemoglobin, the hemoglobin variant, the recombinant hemoglobin or the hemoglobin-based blood substitute to release oxygen to various organs and surrounding tissues in the human body. Background technique [0002] Hemoglobin (hemoglobin, Hb for short) is the protein used to carry and transport oxygen in red blood cells. Hemoglobin in the blood can transport oxygen from respiratory organs such as the respiratory tract and lungs to various organs and surrounding tissues in the human body, and release oxy...

AI Technical Summary

Problems solved by technology

In addition, insufficient oxygen intake may lead to metabolic abnormalities or functional abnormalities of the organs and surrounding tissues, which may lead to various diseases such as hypertension, cardiovascular disease, and neurodegenerative disease , may also cause the growth of cancer cells

A prior art method widely used in the treatment of anemia involves blood transfusion, however, this prior art method is only a passive therapy and other treatments must be administered at the same time to avoid the side effects caused by blood transfusion; for example, it is necessary to administer Give iron-chelating agent (iron-chelating agent) to reduce the iron content in the blood and prevent the patient from developing iron poisoning (iron-poisoning)

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