Application of Phthalide compound medication and medication compounds thereof
A technology for pharmaceutical compositions and compounds, which can be used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as cancer cell growth, abnormal metabolism and abnormality of surrounding tissues, and achieve the effects of preventing abnormal metabolism and inhibiting growth.
A technology for pharmaceutical compositions and compounds, which can be used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as cancer cell growth, abnormal metabolism and abnormality of surrounding tissues, and achieve the effects of preventing abnormal metabolism and inhibiting growth.
CN105380941AInactive Publication Date: 2016-03-09SUN YAT SEN UNIV
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[0050] In order to make the above-mentioned and other objects, features and advantages of the present invention more comprehensible, the preferred embodiments of the present invention are specifically cited below, together with the accompanying drawings, and are described in detail as follows:
[0051] The phthalide compound of the present invention can form at least one hydrogen bond with the Arg141 residue of the alpha subunit of a hemoglobin, a hemoglobin variant, a recombinant hemoglobin or a hemoglobin-based blood substitute to stabilize the hemoglobin, the Alpha of the hemoglobin variant, the recombinant hemoglobin or the hemoglobin-based blood substitute 1 、α 2The interface between the subunits (α1 / α2 interface) promotes the hemoglobin, the hemoglobin variant, the recombinant hemoglobin or the hemoglobin-based blood substitute to stabilize in the T state of low oxygen affinity to help the hemoglobin, The hemoglobin variant, the recombinant hemoglobin or the hemoglobin-...
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A method for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes to organs and peripheral tissues in human bodies is disclosed by administering a compound of phthalides to a subject in need thereof to improve the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes to the organs and the peripheral tissues in human bodies. The compound of phthalides is characterized by a phthalide functional group, and forms at least one hydrogen bond with [alpha]Arg141 of hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes, stabilizing the [alpha]1 / [alpha]2 interface of hemoglobin, further stabilizing the oxygenated hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes in the low oxygen affinity 'T' state and facilitating the oxygen release to the organs and the peripheral tissues. A medication for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin, and hemoglobin-based blood substitutes to organs and peripheral tissues in human bodies is also disclosed.
Description
technical field [0001] The present invention relates to the use of a phthalide compound, in particular to a phthalide compound used to prepare hemoglobin (hemoglobin, Hb for short), hemoglobin variant (hemoglobinvariant), recombinant hemoglobin (recombinanthemoglobin) or hemoglobin-based The use of drugs that release oxygen to various organs and surrounding tissues in the human body. The present invention also relates to a pharmaceutical composition for enhancing the ability of hemoglobin, the hemoglobin variant, the recombinant hemoglobin or the hemoglobin-based blood substitute to release oxygen to various organs and surrounding tissues in the human body. Background technique [0002] Hemoglobin (hemoglobin, Hb for short) is the protein used to carry and transport oxygen in red blood cells. Hemoglobin in the blood can transport oxygen from respiratory organs such as the respiratory tract and lungs to various organs and surrounding tissues in the human body, and release oxy...
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Patent Timeline
09 Mar 2016
Publication
CN105380941A
- IPC
- A61K31/365; A61K31/6615; A61P7/00; A61P7/06; A61P9/12; A61P25/06; A61P35/00; A61P25/28; A61K31/192
- CPC
- A61K31/365; A61K31/6615; A61P7/00; A61P7/06; A61P9/12; A61P25/06; A61P25/28; A61P35/00
- Inventors
- 王家蓁; 马汉德