89 results about "Hemoglobin" patented technology

The invention belongs to the technical field of microorganisms, discloses a strain of pseudomonas putida and application of the strain of pseudomonas putida as fish probiotics, and particularly discloses a strain of pseudomonas putida. The invention provides a symbiotic pseudomonas putida CD separated from fish, and the strain has relatively strong fat utilization capability, can generate a plurality of beneficial extracellular metabolites, can promote metabolism of fish lipids, carbohydrates and proteins and weight gain, and also can improve the iron content and hemoglobin content in fish tissues. The pseudomonas putida strain CD disclosed by the invention has good biological safety, and has a wide development prospect in the aspect of application as fish probiotics.

Methods for treating Wilson Disease with bis-choline tetrathiomolybdate therapy are provided. The methods may include administering 15 mg or between 30 and 90 mg of bis-choline tetrathiomolybdate once daily to a patient exhibiting NCCcorrected, alanine aminotransferase (ALT), hemoglobin, platelets, or neutrophils levels meeting specified criteria. The methods may include modifying treatment by decreasing or increasing the daily dose of bis-choline tetrathiomolybdate or discontinuing treatment for a period of time.

The invention discloses an inorganic phosphorus dry type detection analysis assembly, the assembly sequentially comprises an upper support layer, a diffusion layer, a first reagent layer, a second reagent layer, a support body and a lower support layer from top to bottom, the two ends of the upper support layer and the lower support layer are respectively connected through buckles, and a sample adding hole is formed in the middle position of the upper support layer; a test hole is formed in the middle of the lower supporting layer; reagents contained in the diffusion layer comprise 5-sulfosalicylic acid, succinic acid, a non-ionic high-molecular chemical substance and triton X-100; reagents contained in the first reagent layer comprise a modified 30% binder, a modified acrylic resin emulsion, white glue, ammonium molybdate, ascorbic acid, a surfactant, soluble cellulose ether, a defoaming agent and an active material; a reagent contained in the second reagent layer comprises D4 hydrogel with the concentration of 0.3 g / L. According to the assembly, the problem of multi-layer coating in the prior art is greatly solved, the permeation effect is improved, and the purposes of normal-temperature storage, coating frequency simplification, process simplification and production cost reduction are achieved.

The invention discloses a construction method of genetically engineered bacteria for improving the yield of L-histidine, and belongs to the technical field of bioengineering. Escherichia coli is used as an original strain, and vitreoscilla hemoglobin genes are integrated and overexpressed on a genome of the escherichia coli, so that effective supply of oxygen and ATP is enhanced, and the yield of L-histidine is increased. The genetically engineered bacterium is used for producing the L-histidine by a fermentation method, and the yield of the L-histidine reaches 2.76 g / L at most after fermentation in a shake flask for 48 hours, and is increased by 52.49% compared with an original strain.

This product measures components contained in bodily fluids flowing through a tube, for example, hematocrit and / or hemoglobin values ​​of blood or urine. The tube through which bodily fluids flow can be fixed inside the groove by opening the lid and placing the tube inside the groove formed in the main body, and then closing the lid. The components of the bodily fluid are measured with the tube fixed inside the groove as described above. The cable shown in the perspective reference drawing is for supplying power.

A point-of-care testing (POCT) system comprising an analyzer, a measurement cartridge, and a calibration cartridge for calibrating the measurement cartridge is described. The measurement cartridge comprises at least one electrochemical sensor for measuring the one or more properties of the blood sample, and the calibration cartridge comprises a similar at least one electrochemical sensor and at least one sealed blister containing calibration fluid for calibrating the measurement cartridge. Examples of properties of the blood sample may be pH, blood gases, electrolytes, and metabolites like glucose and creatinine. The measurement cartridge may also comprise an optical chamber for measuring for example, bilirubin and hemoglobin species, for which the analyzer comprises stored calibration algorithms. The optical chamber may be disposed in any location in the measurement cartridge, for receiving a portion of the blood sample.

The invention provides a medicinal and edible nutritional composition for benefiting qi and nourishing blood and application of the medicinal and edible nutritional composition in preparation of a nutritional preparation for improving deficiency of qi and blood, the composition is prepared from gorse lineata, scrophularia ningpoensis, astragalus membranaceus, polygonatum kingianum, angelica sinensis, fructus lycii, lily, lotus seeds and red dates, and the composition can effectively increase leukocyte count, erythrocyte count and hemoglobin content, enhance physical strength and improve the blood circulation. The nutritional effects of benefiting qi and nourishing blood are achieved.

The present invention discloses a treatment agent and a method for improving the feeding attraction of insects or their larvae to aquatic animals. The treatment agent of the present invention contains at least one of nitrates and nitrites, and at least one of ascorbic acid, isoascorbic acid, tea polyphenols and nicotinamide; the treatment method for insects or their larvae comprises the following steps: cleaning the insects or their larvae; soaking the cleaned insects in a solution of the treatment agent of the present invention, taking them out and draining them. The treatment method of the present invention has low cost, is easy to operate, preserves nutrients intact, can kill pathogens in insects, and fixes the hemoglobin of insects, making them less susceptible to oxidation and corruption. In addition, by changing the natural body color of the insects or their larvae, the feeding attraction and palatability of the insects or their larvae as aquatic feed are improved, and the method is easy to promote and apply.

The invention relates to the technical field of salty essence, in particular to high-temperature cooking resistant salty essence which is characterized by comprising the following components in parts by mass: 30-50 parts of hemoglobin, 10-20 parts of compound amino acid, 5-15 parts of modified polysaccharide, 2-8 parts of a natural antioxidant, 1-5 parts of a flavor enhancer, 0.5-3 parts of a pH regulator and 80-120 parts of deionized water. Hemoglobin is derived from one or more of fresh pig blood, cattle blood, sheep blood, chicken blood, duck blood or goose blood and is obtained after anticoagulation, centrifugation, washing and freeze drying, the purity is larger than or equal to 90%, and the water content is smaller than or equal to 5%. The flavor retention rate of the salty essence can reach 85% or above in a high-temperature cooking environment of 100-135 DEG C, which is far higher than that of the traditional salty essence (40-60%), and the problem that the flavor of the existing essence is easy to lose in high-temperature processing of meat products is effectively solved.

The invention relates to the technical field of medicines, in particular to application of huperzine A in treatment of beta-thalassemia. It is found for the first time that the anti-Alzheimer disease drug huperzine A can be directly combined with gamma-globin to inhibit degradation of gamma-globin through a ubiquitin-proteasome pathway, so that the stability of gamma-globin and the fetal hemoglobin level are improved; the abnormal erythropoiesis and hemolysis phenotype of the beta-thalassemia are improved under the condition of not changing the mRNA expression. Animal experiments show that huperzine A obviously improves hematocrit and the number of red blood cells, reduces the size distribution width of the red blood cells and the proportion of reticulocytes, relieves oxidative stress, hemolysis, splenomegaly and iron overload, and has no obvious liver and kidney toxicity. The invention creatively provides a new strategy for improving HbF by regulating and controlling protein homeostasis instead of transcriptional up-regulation, and provides a new drug action mechanism and application direction for treatment of beta-thalassemia and other hemoglobin diseases.

Described herein is a method of preserving a biological tissue sample ex vivo, the method comprising comprises contacting the tissue sample ex vivo with a perfusion solution comprising polymerized hemoglobin, wherein the perfusion solution comprises less than 5% by weight low molecular weight hemoglobin species, based on the total weight of the perfusion solution.

Disclosed is the use of a composition comprising a TET pathway inhibitor and a ferroptosis inducer in the manufacture of a medicament for the treatment of malignant tumors. It is found that TET1 up-regulates expression of a ferroptosis key regulation gene GCH1 through an NF [kappa] B signal, promotes synthesis of BH4, activates a GPX4 non-dependent pathway, and plays a key hub role in controlling ferroptosis sensitivity. Through combined use of TET pathway inhibitors (including a TET inhibitor and a BH4 synthesis inhibitor), the sensitivity of tumor cells to the ferroptosis inducer can be significantly improved, and the in-vivo use dosage of the ferroptosis inducer is reduced to 1% (1 mg / kg) of the conventional treatment dosage. The composition of the TET pathway inhibitor and the ferroptosis inducer, provided by the invention, can be used for remarkably improving the ferroptosis induction curative effect of various malignant tumors, particularly ferroptosis insensitive tumors, and enhancing the safety and universality of ferroptosis induction treatment.

The present invention relates to novel polymorphic forms of Iptacopan hydrochloride and preparation thereof. The invention also relates to pharmaceutical composition comprising novel polymorphic forms of Iptacopan hydrochloride and their use in the treatment of paroxysmal nocturnal hemoglobinuria and proteinuria.

This invention relates to the field of food, medicine, and health products technology, and particularly to a composition based on jujube plants that has the effects of replenishing qi and blood, improving sleep, and its preparation method. The composition includes jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate, spearmint extract, saffron extract, and other medicinal and edible ingredients. With jujube extract as the core, and in combination with collagen peptides, pomegranate concentrate, saffron, and spearmint extracts, it achieves integrated health intervention through multi-target action, replenishing qi and blood, improving sleep, and repairing skin.

Techniques and systems include predicting various health conditions using a photoplethysmography (PPG) signal or a video signal based on images of a patient's fingertip or other body portion captured using a mobile device. The video signal may be transformed into a pseudo PPG signal to measure blood volume changes in the patient's blood flow to derive data indicating a disease state or health-related characteristic, such as blood oxygen level, blood glucose level, heart rate variability, hemoglobin, respiration rate, or arrhythmia. Techniques involve real-time environment assessment and problematic issue detection, training an artificial intelligence (AI) model to measure signal quality so as to select high-quality signals from a range of signals, and domain adaption and transfer learning to make use of publicly available datasets.

A nanoparticle comprising a core and a shell, wherein the core includes an antimicrobial and hemoglobin, the shell includes a polyunsaturated fatty acids (PUFA)-containing cell membrane, and the antimicrobial sensitizes bacteria to oxidant killing.

The application belongs to the technical field of microorganisms, and provides a Streptococcus salivarius subsp. thermophilus HX-ST36, which has a preservation number of CGMCC NO. 32955. The Streptococcus salivarius subsp. thermophilus provided by the application can ferment Astragalus membranaceus Bunge-Angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the fermentation product thereof can significantly inhibit the writhing response, and can realize the effects of relieving dysmenorrhea and tonifying blood by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the hemoglobin (HGB) content. The effect of the fermentation product in removing dampness is verified by improving the dampness signs of a crowd. The application further provides a probiotic preparation and a preparation method of a probiotic fermentation product. The preparation method of the probiotic preparation and the probiotic fermentation product is simple and can be produced on a large scale.

This invention discloses a hematopoietic nutritional steamed bun for piglets, comprising: 35-45 parts corn, 10-15 parts whey powder, 8-10 parts puffed soybeans, 8-10 parts fermented Chinese herbal medicines, 6-8 parts soybean meal, 4-6 parts fish meal, 2-5 parts milk powder, 0.3-0.6 parts compound vitamins, 0.1-0.3 parts compound microminerals, 0.1-0.3 parts zinc oxide, and 0.02-0.05 parts 5-hydroxytryptophan; the fermented Chinese herbal medicines include: 8-12 parts Codonopsis pilosula, 8-12 parts Astragalus membranaceus, 6-10 parts Aucklandia lappa, 8-12 parts Atractylodes macrocephala, 8-12 parts Poria cocos, 12-17 parts longan pulp, 12-17 parts Rehmannia glutinosa, 8-12 parts dried ginger, and 12-17 parts prepared licorice root; the fermented Chinese herbal medicines are obtained by fermentation after ultra-fine grinding of the herbal raw materials. This invention uses fermented Chinese herbal medicines and further optimizes the strains and fermentation process. By scientifically combining various functional nutrients, it systematically promotes hemoglobin synthesis, regulates the intestines, and enhances immune function in piglets, targeting the physiological characteristics of piglets during the peripartum and weaning transition periods, thereby achieving the comprehensive effect of promoting growth and reducing mortality.

The present invention relates to a biomarker for predicting early mortality in cervical cancer patients. As a result of analyzing changes in hematologic factors before and after treatment in cervical cancer patients who have undergone anticancer radiation treatment, it was confirmed that changes in compete blood count (CBC) representing absolute neutrophil count (ANC) level (cells / μL), platelet (PLT) level (cells / μL), hemoglobin (Hb) level (g / dL), or monocyte (Mo) count (cells / μL) were associated with early mortality, and plasma-derived exosome RNA associated with the changes in the CBC was found to be capable of predicting early mortality in a cervical cancer patient data cohort, thereby being provided as a biomarker associated with early mortality of cervical cancer patients.

The invention relates to the field of feed processing, and discloses a compound premix feed for aquatic products, which comprises the following raw materials in percentage by weight: 15% of sweet wormwood, 15% of Sanhuang, 5% of ginger powder, 15% of wormwood, 15% of honeysuckle, 15% of dandelion, 5% of ferrous sulfate and 15% of vitamin B6, the weight ratio of the rhizoma coptidis to the cortex phellodendri to the radix scutellariae is 1: 1: 1. Amur corktree bark has the effects of clearing away heat and toxic materials, eliminating dampness and stopping diarrhea and can improve water quality and reduce reproduction and pollution of harmful microorganisms, honeysuckle flowers have the effects of clearing away heat and toxic materials and resisting bacteria and can directly act on fishes and shrimps and can indirectly purify water quality and maintain cleanliness and stability of water, ferrous sulfate supplements iron elements needed by the fishes and shrimps, and the fish and shrimp feed additive is free of toxic and side effects. The fish and shrimps can effectively absorb nutrient substances in water, promote synthesis of hemoglobin, improve oxygen transport capacity, help the fish and shrimps to better absorb the nutrient substances in the water, and reduce dependence and pollution on the environment.

The utility model discloses a high-temperature drying tower with a cleaning function for producing spray-dried blood cells, which comprises a drying mechanism, a cleaning mechanism and a driving mechanism, and is characterized in that the drying mechanism comprises a drying tower body, a feeding channel connected and communicated with the drying tower body, and the cleaning mechanism; the cleaning mechanism comprises a water pipe penetrating through the top of the drying tower body. When the interior of the drying tower body is cleaned, water is injected into the water pipe, then clear water in the water pipe penetrates through the opening, flows out of the pipe sleeve, enters the pipe body and is sprayed out from the multiple spray heads, the purpose of washing the inner wall of the drying tower body is achieved, and meanwhile, an operator pulls the pull rope back and forth in a reciprocating mode, so that the inner wall of the drying tower body is cleaned. Then the rod body drives the pipe body and the rubber scraping plate to rotate, the rubber scraping plate scrapes off caked raw materials, then the inner wall of the drying tower body is washed clean during rotation of the spray head, and the cleaning effect is good.

The present disclosure relates to an apparatus for measuring hemoglobin and a method for measuring hemoglobin concentration by using same.

The invention relates to the technical field of hemoglobin extraction equipment, and particularly discloses a goose hemoglobin active peptide separation and extraction method and device, linkage of three functions of centrifugation, lifting and stirring is realized through single motor driving, separation stability is ensured in combination with a ratchet-pawl transmission mechanism, and multistage membrane separation is coupled through lifting motion of a separation cylinder, so that the separation efficiency is improved. The device integrates an ultrasonic module, a temperature control module and a PH adjusting module, so that the whole-process integrated operation is realized, and the technical bottlenecks of large activity loss and low efficiency of the traditional method are solved.

The application belongs to the technical field of biosensors and provides an electrochemical biosensor for detecting ochratoxin A based on DNA tetrahedron, which comprises an A-P probe, a gold electrode with a modified capture probe CP, a circular template CT, phi 29 polymerase, dNTPs, Mg 2+ , hemoglobin, K + , H2O2; the A-P probe is obtained by hybridization of an aptamer Apt and a primer P; the nucleotide sequences of the aptamer Apt, the primer P, the capture probe CP and the circular template CT are shown as SEQ ID NO: 1-4; the 5' end of the capture probe CP is modified with SH. The sensor has a simple preparation method, stable performance and is suitable for the detection of OTA in food and environment; the process cost of the preparation process is low, the performance is stable, the electrode has good repeatability and is suitable for the requirements of cheapness in industrialization.

The application provides a glycated hemoglobin dissociation reagent and application thereof, and belongs to the technical field of biological detection. The dissociation reagent comprises 10-50 mM Tris buffer, 0.2-0.5 M ammonium chloride, 0.5%-1.0% (v / v) triton X-100, 0.2 wt%-1.0 wt% BSA and 0.02-0.2 M sodium chloride. When the dissociation reagent is used to dissociate a whole blood sample, the hemoglobin can be dissociated by mixing the dissociation reagent with the whole blood sample for 20-60 s, and a clear and transparent solution is obtained. The dissociation reagent can be used to prepare a kit for dissociating or / and detecting glycated hemoglobin. The glycated hemoglobin obtained by using the dissociation reagent can be directly used for fluorescence immunoassay, the interference of the color of hemoglobin itself on immunochromatographic detection is avoided, and the sensitivity is high and the repeatability is good.

The present invention discloses a surface modification method of a pyrochlore oxide and its application, and belongs to the technical field of inorganic materials. The surface modification method of a pyrochlore oxide provided by the present invention comprises the following steps: using ascorbic acid to perform surface modification treatment on the pyrochlore oxide to obtain surface-modified pyrochlore oxide. The present invention utilizes the dual functional characteristics of ascorbic acid, namely acidity and reducibility, to perform surface modification treatment on the pyrochlore oxide, etches the passivation layer contained on its surface, exposes sites with high catalytic activity, and after surface treatment, tensile strain is generated on its crystal surface, resulting in a large amount of lattice distortion. This change in the distance between lattice atoms causes the energy level of its outer electrons to change, significantly improving the electrochemical reaction activity of the pyrochlore oxide material. The surface-modified pyrochlore oxide obtained by the present invention is widely used as a catalyst, especially as a catalyst for hydrogen production by electrolysis of water.

Provided is a method for measuring glycated hemoglobin in a sample containing hemoglobin and plasma, the method including reacting glycated hemoglobin in a sample containing hemoglobin and plasma, a proteolytic enzyme, and a fructosyl peptide oxidase to generate hydrogen peroxide, and measuring the generated hydrogen peroxide, wherein the reaction is performed in the presence of ferrocyanide and a ferrocene derivative.

The invention relates to the technical field of deep learning, in particular to an extracorporeal circulation data analysis method and system based on deep learning, and the method comprises the following steps: collecting pump rotating speed, pump flow, arterial perfusion pressure, arteriovenous blood oxygen saturation, hemoglobin and lactic acid, carrying out the time alignment, completing the time sequence coding, and forming state characterization; the method comprises the following steps: correcting a state evolution direction by combining a relationship between oxygen delivery and oxygen extraction, introducing a lactic acid change trend to constrain time sequence consistency, constructing a circulating resistance matching perfusion capability according to flow and pressure, continuously correcting a state change direction, and generating an operation state analysis result. Oxygen delivery and oxygen extraction constraints are introduced to correct state evolution, a lactic acid trend is combined to strengthen time sequence consistency, resistance constraints are formed by perfusion pressure and flow, perfusion capacity changes are continuously corrected, and nonlinear state expression stability and overall interpretation coherence are improved.