67 results about "Hemoglobin" patented technology

The invention belongs to the technical field of microorganisms, discloses a strain of pseudomonas putida and application of the strain of pseudomonas putida as fish probiotics, and particularly discloses a strain of pseudomonas putida. The invention provides a symbiotic pseudomonas putida CD separated from fish, and the strain has relatively strong fat utilization capability, can generate a plurality of beneficial extracellular metabolites, can promote metabolism of fish lipids, carbohydrates and proteins and weight gain, and also can improve the iron content and hemoglobin content in fish tissues. The pseudomonas putida strain CD disclosed by the invention has good biological safety, and has a wide development prospect in the aspect of application as fish probiotics.

The present invention discloses a treatment agent and a method for improving the feeding attraction of insects or their larvae to aquatic animals. The treatment agent of the present invention contains at least one of nitrates and nitrites, and at least one of ascorbic acid, isoascorbic acid, tea polyphenols and nicotinamide; the treatment method for insects or their larvae comprises the following steps: cleaning the insects or their larvae; soaking the cleaned insects in a solution of the treatment agent of the present invention, taking them out and draining them. The treatment method of the present invention has low cost, is easy to operate, preserves nutrients intact, can kill pathogens in insects, and fixes the hemoglobin of insects, making them less susceptible to oxidation and corruption. In addition, by changing the natural body color of the insects or their larvae, the feeding attraction and palatability of the insects or their larvae as aquatic feed are improved, and the method is easy to promote and apply.

The invention relates to the technical field of salty essence, in particular to high-temperature cooking resistant salty essence which is characterized by comprising the following components in parts by mass: 30-50 parts of hemoglobin, 10-20 parts of compound amino acid, 5-15 parts of modified polysaccharide, 2-8 parts of a natural antioxidant, 1-5 parts of a flavor enhancer, 0.5-3 parts of a pH regulator and 80-120 parts of deionized water. Hemoglobin is derived from one or more of fresh pig blood, cattle blood, sheep blood, chicken blood, duck blood or goose blood and is obtained after anticoagulation, centrifugation, washing and freeze drying, the purity is larger than or equal to 90%, and the water content is smaller than or equal to 5%. The flavor retention rate of the salty essence can reach 85% or above in a high-temperature cooking environment of 100-135 DEG C, which is far higher than that of the traditional salty essence (40-60%), and the problem that the flavor of the existing essence is easy to lose in high-temperature processing of meat products is effectively solved.

The invention relates to the technical field of medicines, in particular to application of huperzine A in treatment of beta-thalassemia. It is found for the first time that the anti-Alzheimer disease drug huperzine A can be directly combined with gamma-globin to inhibit degradation of gamma-globin through a ubiquitin-proteasome pathway, so that the stability of gamma-globin and the fetal hemoglobin level are improved; the abnormal erythropoiesis and hemolysis phenotype of the beta-thalassemia are improved under the condition of not changing the mRNA expression. Animal experiments show that huperzine A obviously improves hematocrit and the number of red blood cells, reduces the size distribution width of the red blood cells and the proportion of reticulocytes, relieves oxidative stress, hemolysis, splenomegaly and iron overload, and has no obvious liver and kidney toxicity. The invention creatively provides a new strategy for improving HbF by regulating and controlling protein homeostasis instead of transcriptional up-regulation, and provides a new drug action mechanism and application direction for treatment of beta-thalassemia and other hemoglobin diseases.

Described herein is a method of preserving a biological tissue sample ex vivo, the method comprising comprises contacting the tissue sample ex vivo with a perfusion solution comprising polymerized hemoglobin, wherein the perfusion solution comprises less than 5% by weight low molecular weight hemoglobin species, based on the total weight of the perfusion solution.

Disclosed is the use of a composition comprising a TET pathway inhibitor and a ferroptosis inducer in the manufacture of a medicament for the treatment of malignant tumors. It is found that TET1 up-regulates expression of a ferroptosis key regulation gene GCH1 through an NF [kappa] B signal, promotes synthesis of BH4, activates a GPX4 non-dependent pathway, and plays a key hub role in controlling ferroptosis sensitivity. Through combined use of TET pathway inhibitors (including a TET inhibitor and a BH4 synthesis inhibitor), the sensitivity of tumor cells to the ferroptosis inducer can be significantly improved, and the in-vivo use dosage of the ferroptosis inducer is reduced to 1% (1 mg / kg) of the conventional treatment dosage. The composition of the TET pathway inhibitor and the ferroptosis inducer, provided by the invention, can be used for remarkably improving the ferroptosis induction curative effect of various malignant tumors, particularly ferroptosis insensitive tumors, and enhancing the safety and universality of ferroptosis induction treatment.

The present invention relates to novel polymorphic forms of Iptacopan hydrochloride and preparation thereof. The invention also relates to pharmaceutical composition comprising novel polymorphic forms of Iptacopan hydrochloride and their use in the treatment of paroxysmal nocturnal hemoglobinuria and proteinuria.

This invention relates to the field of food, medicine, and health products technology, and particularly to a composition based on jujube plants that has the effects of replenishing qi and blood, improving sleep, and its preparation method. The composition includes jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate, spearmint extract, saffron extract, and other medicinal and edible ingredients. With jujube extract as the core, and in combination with collagen peptides, pomegranate concentrate, saffron, and spearmint extracts, it achieves integrated health intervention through multi-target action, replenishing qi and blood, improving sleep, and repairing skin.

Techniques and systems include predicting various health conditions using a photoplethysmography (PPG) signal or a video signal based on images of a patient's fingertip or other body portion captured using a mobile device. The video signal may be transformed into a pseudo PPG signal to measure blood volume changes in the patient's blood flow to derive data indicating a disease state or health-related characteristic, such as blood oxygen level, blood glucose level, heart rate variability, hemoglobin, respiration rate, or arrhythmia. Techniques involve real-time environment assessment and problematic issue detection, training an artificial intelligence (AI) model to measure signal quality so as to select high-quality signals from a range of signals, and domain adaption and transfer learning to make use of publicly available datasets.

The application belongs to the technical field of microorganisms, and provides a Streptococcus salivarius subsp. thermophilus HX-ST36, which has a preservation number of CGMCC NO. 32955. The Streptococcus salivarius subsp. thermophilus provided by the application can ferment Astragalus membranaceus Bunge-Angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the fermentation product thereof can significantly inhibit the writhing response, and can realize the effects of relieving dysmenorrhea and tonifying blood by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the hemoglobin (HGB) content. The effect of the fermentation product in removing dampness is verified by improving the dampness signs of a crowd. The application further provides a probiotic preparation and a preparation method of a probiotic fermentation product. The preparation method of the probiotic preparation and the probiotic fermentation product is simple and can be produced on a large scale.

This invention discloses a hematopoietic nutritional steamed bun for piglets, comprising: 35-45 parts corn, 10-15 parts whey powder, 8-10 parts puffed soybeans, 8-10 parts fermented Chinese herbal medicines, 6-8 parts soybean meal, 4-6 parts fish meal, 2-5 parts milk powder, 0.3-0.6 parts compound vitamins, 0.1-0.3 parts compound microminerals, 0.1-0.3 parts zinc oxide, and 0.02-0.05 parts 5-hydroxytryptophan; the fermented Chinese herbal medicines include: 8-12 parts Codonopsis pilosula, 8-12 parts Astragalus membranaceus, 6-10 parts Aucklandia lappa, 8-12 parts Atractylodes macrocephala, 8-12 parts Poria cocos, 12-17 parts longan pulp, 12-17 parts Rehmannia glutinosa, 8-12 parts dried ginger, and 12-17 parts prepared licorice root; the fermented Chinese herbal medicines are obtained by fermentation after ultra-fine grinding of the herbal raw materials. This invention uses fermented Chinese herbal medicines and further optimizes the strains and fermentation process. By scientifically combining various functional nutrients, it systematically promotes hemoglobin synthesis, regulates the intestines, and enhances immune function in piglets, targeting the physiological characteristics of piglets during the peripartum and weaning transition periods, thereby achieving the comprehensive effect of promoting growth and reducing mortality.

The utility model discloses a high-temperature drying tower with a cleaning function for producing spray-dried blood cells, which comprises a drying mechanism, a cleaning mechanism and a driving mechanism, and is characterized in that the drying mechanism comprises a drying tower body, a feeding channel connected and communicated with the drying tower body, and the cleaning mechanism; the cleaning mechanism comprises a water pipe penetrating through the top of the drying tower body. When the interior of the drying tower body is cleaned, water is injected into the water pipe, then clear water in the water pipe penetrates through the opening, flows out of the pipe sleeve, enters the pipe body and is sprayed out from the multiple spray heads, the purpose of washing the inner wall of the drying tower body is achieved, and meanwhile, an operator pulls the pull rope back and forth in a reciprocating mode, so that the inner wall of the drying tower body is cleaned. Then the rod body drives the pipe body and the rubber scraping plate to rotate, the rubber scraping plate scrapes off caked raw materials, then the inner wall of the drying tower body is washed clean during rotation of the spray head, and the cleaning effect is good.

The present disclosure relates to an apparatus for measuring hemoglobin and a method for measuring hemoglobin concentration by using same.

The invention relates to the technical field of hemoglobin extraction equipment, and particularly discloses a goose hemoglobin active peptide separation and extraction method and device, linkage of three functions of centrifugation, lifting and stirring is realized through single motor driving, separation stability is ensured in combination with a ratchet-pawl transmission mechanism, and multistage membrane separation is coupled through lifting motion of a separation cylinder, so that the separation efficiency is improved. The device integrates an ultrasonic module, a temperature control module and a PH adjusting module, so that the whole-process integrated operation is realized, and the technical bottlenecks of large activity loss and low efficiency of the traditional method are solved.

The application belongs to the technical field of biosensors and provides an electrochemical biosensor for detecting ochratoxin A based on DNA tetrahedron, which comprises an A-P probe, a gold electrode with a modified capture probe CP, a circular template CT, phi 29 polymerase, dNTPs, Mg 2+ , hemoglobin, K + , H2O2; the A-P probe is obtained by hybridization of an aptamer Apt and a primer P; the nucleotide sequences of the aptamer Apt, the primer P, the capture probe CP and the circular template CT are shown as SEQ ID NO: 1-4; the 5' end of the capture probe CP is modified with SH. The sensor has a simple preparation method, stable performance and is suitable for the detection of OTA in food and environment; the process cost of the preparation process is low, the performance is stable, the electrode has good repeatability and is suitable for the requirements of cheapness in industrialization.

The application provides a glycated hemoglobin dissociation reagent and application thereof, and belongs to the technical field of biological detection. The dissociation reagent comprises 10-50 mM Tris buffer, 0.2-0.5 M ammonium chloride, 0.5%-1.0% (v / v) triton X-100, 0.2 wt%-1.0 wt% BSA and 0.02-0.2 M sodium chloride. When the dissociation reagent is used to dissociate a whole blood sample, the hemoglobin can be dissociated by mixing the dissociation reagent with the whole blood sample for 20-60 s, and a clear and transparent solution is obtained. The dissociation reagent can be used to prepare a kit for dissociating or / and detecting glycated hemoglobin. The glycated hemoglobin obtained by using the dissociation reagent can be directly used for fluorescence immunoassay, the interference of the color of hemoglobin itself on immunochromatographic detection is avoided, and the sensitivity is high and the repeatability is good.

Provided is a method for measuring glycated hemoglobin in a sample containing hemoglobin and plasma, the method including reacting glycated hemoglobin in a sample containing hemoglobin and plasma, a proteolytic enzyme, and a fructosyl peptide oxidase to generate hydrogen peroxide, and measuring the generated hydrogen peroxide, wherein the reaction is performed in the presence of ferrocyanide and a ferrocene derivative.

The invention relates to the technical field of deep learning, in particular to an extracorporeal circulation data analysis method and system based on deep learning, and the method comprises the following steps: collecting pump rotating speed, pump flow, arterial perfusion pressure, arteriovenous blood oxygen saturation, hemoglobin and lactic acid, carrying out the time alignment, completing the time sequence coding, and forming state characterization; the method comprises the following steps: correcting a state evolution direction by combining a relationship between oxygen delivery and oxygen extraction, introducing a lactic acid change trend to constrain time sequence consistency, constructing a circulating resistance matching perfusion capability according to flow and pressure, continuously correcting a state change direction, and generating an operation state analysis result. Oxygen delivery and oxygen extraction constraints are introduced to correct state evolution, a lactic acid trend is combined to strengthen time sequence consistency, resistance constraints are formed by perfusion pressure and flow, perfusion capacity changes are continuously corrected, and nonlinear state expression stability and overall interpretation coherence are improved.

The invention discloses application of polymerized hemoglobin, carbon-oxygen polymerized hemoglobin and a preparation method of the carbon-oxygen polymerized hemoglobin. Polymeric hemoglobin can be used for preparing medicines for treating sepsis and complications thereof.

Systems, devices, and methods for performing transabdominal fetal oximetry and / or transabdominal fetal pulse oximetry using physiological characteristics and / or calibration factors can receive a physiological characteristic of a pregnant mammal and determine one or more potential effects of the physiological characteristic on the behavior of a light signal projected into the abdomen of the pregnant mammal. Then, in response to the effects, a calibration factor for the light signal can be determined. Then, the calibration factor can be used to calibrate fetal detection electronic signals so that levels of fetal hemoglobin oxygen saturation can be determined.

To provide a device and a method for easily hemolyzing / diluting puncture blood even is the device is an A1c measuring device using the HPLC method.SOLUTION: Glycosylated hemoglobin (A1c%) is measured by a chip set that is formed of a conical or pyramid-shaped chip made of resin that can suck up puncture blood by a capillary phenomenon, a container that can store the chip, and a lid body that can seal the container, and can collect the puncture blood and hemolyze and dilute the blood, the chip set capable of collecting puncture blood and hemolyzing and diluting the blood, wherein the container has an inner diameter larger than the maximum outer diameter of the chip by 0.5 to 5 mm, and the container has therein a flange that has a columnar shape having a height allowing storage of the chip and is at a position 5 to 15 mm from a top face of the container, and a method for collecting puncture blood and hemolyzing / diluting the blood by using the chip.SELECTED DRAWING: Figure 7

A method for detecting a molecule in a sample includes applying a first filter to an image at a first wavelength. The method also includes applying a second filter to the image at a second wavelength. The method also includes applying a third filter to the image at a third wavelength. The first, second, and third wavelengths are within a predetermined wavelength range, and wherein first, second, and third wavelengths are different from one another. The method also includes detecting a spectral signature for the molecule in the sample in the image after the first, second, and third filters are applied to the image. The method also includes determining whether the molecule is present in the sample based at least partially upon the detected spectral signature.

The invention provides a rapid and cheap method for detecting medetomidate hydrochloride and analogues thereof by using metalloporphyrin, and aims to solve the problems of high cost, tedious operation and the like caused by dependence on complex equipment in the prior art. The method is based on the characteristic that metalloporphyrin and imidazole ring nitrogen atoms in medetomidate hydrochloride and analogues thereof are subjected to coordination reaction, and after a complex is formed, the color of a solution is changed from reddish brown to yellow green. In addition, an ultraviolet-visible spectrophotometer can be used for further verifying the red shift phenomenon of a Sore absorption peak in an absorbance curve. In specific implementation, a sample to be detected is dissolved in anhydrous dichloromethane, a metalloporphyrin solution is added and mixed, and qualitative analysis is realized by visually observing color change or detecting absorbance change by means of an instrument. Preferably, the metalloporphyrin comprises hemin, 5, 10, 15, 20-tetraphenylporphyrin iron (III) chloride and the like, and the substances to be detected contain analogues such as medetomidate hydrochloride, etomidate hydrochloride and the like. Experimental results show that the method has high sensitivity and reliability, is suitable for rapidly screening medetomidate hydrochloride-containing cigarettes and other samples, and provides a convenient detection means for law enforcement departments.

This utility model relates to the field of comprehensive utilization technology of livestock and poultry blood, and discloses a device for extracting hemoglobin from livestock and poultry blood. The device includes a reaction vessel with an inlet at the top and an outlet at the bottom. An internal stirring shaft with several shearing blades is installed on the stirring shaft. A hollow jacket for condensation is provided on the outer wall of the reaction vessel. Several ultrasonic generators are detachably mounted on the reaction vessel. Several connecting pipes are connected through the reaction vessel, with a positioning sleeve with a sealing groove at the end of each connecting pipe and a sealing ring fitted on the positioning sleeve. The ultrasonic generators are sealed to the reaction vessel body via an installation kit. This utility model has a simple structure, compact design, and is easy to use. The ultrasonic generators are detachably mounted on the reaction vessel body and sealed by the installation kit, improving the processing efficiency of livestock and poultry blood, ensuring thorough cell disruption, and facilitating hemoglobin extraction. Simultaneously, the hollow jacket on the outside of the reaction vessel for cooling and condensation effectively reduces the temperature rise caused by the operation of the ultrasonic generators.

The utility model discloses a pig blood cell protein powder raw material premixing homogenizer which comprises a high-pressure tank body, the upper end of the high-pressure tank body is fixedly connected with a defoaming agent box, the surface of the defoaming agent box is connected with a round rod in a sliding mode through a through hole, one end of the round rod is fixedly connected with a round block, and the other end of the round rod is fixedly connected with a push plate. And scales are processed on the surface of the defoaming agent box. Through the arrangement of the high-pressure tank body, the defoaming agent box, the round rod, the push plate, the round block and the hose, when a defoaming agent needs to be added into a raw material in the high-pressure tank body, an operator pulls the round block, the round block drives the round rod to move, and the round rod drives the push plate fixed at the other end to move; through the mode, an operator can quickly add a defoaming agent solution in a proper proportion into the high-pressure tank body to be mixed with raw materials, so that the condition that the premixing effect of the pig blood cell protein powder raw materials is poor is avoided, and the working effect of the premixing homogenizer is improved.

Provided is a glycated hemoglobin measuring apparatus. The apparatus for measuring glycated hemoglobin includes a cartridge for receiving blood and a plurality of chemicals, a rotating tray for rotating the cartridge, wherein the cartridge is disposed inside the rotating tray, a driver having a nozzle disposed above the cartridge and movable in a vertical direction, and a measurement unit located above the cartridge and measuring glycated hemoglobin of the blood, wherein the driver sucks at least one of the blood, the plurality of chemicals, and mixed solution of the blood and the plurality of chemicals into the nozzle or discharges the sucked at least one into the cartridge such that the blood is chemically treated through the plurality of chemicals.

Methods and preparations to identify compounds useful for the treatment of hemoglobin-related disorders including sickle cell disorders, diseases, and conditions, and thalassemia are described. The disclosure also provides methods for the treatment of hemoglobin-related disorders including sickle cell disorders, diseases, and conditions, and thalassemia, that include administering DCN-1 modulating compounds, such as DCN-1 inhibitors, including covalent DCN-1 inhibitors.