50 results about "Hemoglobin" patented technology

The invention relates to the technical field of salty essence, in particular to high-temperature cooking resistant salty essence which is characterized by comprising the following components in parts by mass: 30-50 parts of hemoglobin, 10-20 parts of compound amino acid, 5-15 parts of modified polysaccharide, 2-8 parts of a natural antioxidant, 1-5 parts of a flavor enhancer, 0.5-3 parts of a pH regulator and 80-120 parts of deionized water. Hemoglobin is derived from one or more of fresh pig blood, cattle blood, sheep blood, chicken blood, duck blood or goose blood and is obtained after anticoagulation, centrifugation, washing and freeze drying, the purity is larger than or equal to 90%, and the water content is smaller than or equal to 5%. The flavor retention rate of the salty essence can reach 85% or above in a high-temperature cooking environment of 100-135 DEG C, which is far higher than that of the traditional salty essence (40-60%), and the problem that the flavor of the existing essence is easy to lose in high-temperature processing of meat products is effectively solved.

The invention relates to the technical field of medicines, in particular to application of huperzine A in treatment of beta-thalassemia. It is found for the first time that the anti-Alzheimer disease drug huperzine A can be directly combined with gamma-globin to inhibit degradation of gamma-globin through a ubiquitin-proteasome pathway, so that the stability of gamma-globin and the fetal hemoglobin level are improved; the abnormal erythropoiesis and hemolysis phenotype of the beta-thalassemia are improved under the condition of not changing the mRNA expression. Animal experiments show that huperzine A obviously improves hematocrit and the number of red blood cells, reduces the size distribution width of the red blood cells and the proportion of reticulocytes, relieves oxidative stress, hemolysis, splenomegaly and iron overload, and has no obvious liver and kidney toxicity. The invention creatively provides a new strategy for improving HbF by regulating and controlling protein homeostasis instead of transcriptional up-regulation, and provides a new drug action mechanism and application direction for treatment of beta-thalassemia and other hemoglobin diseases.

Disclosed is the use of a composition comprising a TET pathway inhibitor and a ferroptosis inducer in the manufacture of a medicament for the treatment of malignant tumors. It is found that TET1 up-regulates expression of a ferroptosis key regulation gene GCH1 through an NF [kappa] B signal, promotes synthesis of BH4, activates a GPX4 non-dependent pathway, and plays a key hub role in controlling ferroptosis sensitivity. Through combined use of TET pathway inhibitors (including a TET inhibitor and a BH4 synthesis inhibitor), the sensitivity of tumor cells to the ferroptosis inducer can be significantly improved, and the in-vivo use dosage of the ferroptosis inducer is reduced to 1% (1 mg / kg) of the conventional treatment dosage. The composition of the TET pathway inhibitor and the ferroptosis inducer, provided by the invention, can be used for remarkably improving the ferroptosis induction curative effect of various malignant tumors, particularly ferroptosis insensitive tumors, and enhancing the safety and universality of ferroptosis induction treatment.

The present invention relates to novel polymorphic forms of Iptacopan hydrochloride and preparation thereof. The invention also relates to pharmaceutical composition comprising novel polymorphic forms of Iptacopan hydrochloride and their use in the treatment of paroxysmal nocturnal hemoglobinuria and proteinuria.

This invention relates to the field of food, medicine, and health products technology, and particularly to a composition based on jujube plants that has the effects of replenishing qi and blood, improving sleep, and its preparation method. The composition includes jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate, spearmint extract, saffron extract, and other medicinal and edible ingredients. With jujube extract as the core, and in combination with collagen peptides, pomegranate concentrate, saffron, and spearmint extracts, it achieves integrated health intervention through multi-target action, replenishing qi and blood, improving sleep, and repairing skin.

The application belongs to the technical field of microorganisms, and provides a Streptococcus salivarius subsp. thermophilus HX-ST36, which has a preservation number of CGMCC NO. 32955. The Streptococcus salivarius subsp. thermophilus provided by the application can ferment Astragalus membranaceus Bunge-Angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the fermentation product thereof can significantly inhibit the writhing response, and can realize the effects of relieving dysmenorrhea and tonifying blood by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the hemoglobin (HGB) content. The effect of the fermentation product in removing dampness is verified by improving the dampness signs of a crowd. The application further provides a probiotic preparation and a preparation method of a probiotic fermentation product. The preparation method of the probiotic preparation and the probiotic fermentation product is simple and can be produced on a large scale.

This invention discloses a hematopoietic nutritional steamed bun for piglets, comprising: 35-45 parts corn, 10-15 parts whey powder, 8-10 parts puffed soybeans, 8-10 parts fermented Chinese herbal medicines, 6-8 parts soybean meal, 4-6 parts fish meal, 2-5 parts milk powder, 0.3-0.6 parts compound vitamins, 0.1-0.3 parts compound microminerals, 0.1-0.3 parts zinc oxide, and 0.02-0.05 parts 5-hydroxytryptophan; the fermented Chinese herbal medicines include: 8-12 parts Codonopsis pilosula, 8-12 parts Astragalus membranaceus, 6-10 parts Aucklandia lappa, 8-12 parts Atractylodes macrocephala, 8-12 parts Poria cocos, 12-17 parts longan pulp, 12-17 parts Rehmannia glutinosa, 8-12 parts dried ginger, and 12-17 parts prepared licorice root; the fermented Chinese herbal medicines are obtained by fermentation after ultra-fine grinding of the herbal raw materials. This invention uses fermented Chinese herbal medicines and further optimizes the strains and fermentation process. By scientifically combining various functional nutrients, it systematically promotes hemoglobin synthesis, regulates the intestines, and enhances immune function in piglets, targeting the physiological characteristics of piglets during the peripartum and weaning transition periods, thereby achieving the comprehensive effect of promoting growth and reducing mortality.

The utility model discloses a high-temperature drying tower with a cleaning function for producing spray-dried blood cells, which comprises a drying mechanism, a cleaning mechanism and a driving mechanism, and is characterized in that the drying mechanism comprises a drying tower body, a feeding channel connected and communicated with the drying tower body, and the cleaning mechanism; the cleaning mechanism comprises a water pipe penetrating through the top of the drying tower body. When the interior of the drying tower body is cleaned, water is injected into the water pipe, then clear water in the water pipe penetrates through the opening, flows out of the pipe sleeve, enters the pipe body and is sprayed out from the multiple spray heads, the purpose of washing the inner wall of the drying tower body is achieved, and meanwhile, an operator pulls the pull rope back and forth in a reciprocating mode, so that the inner wall of the drying tower body is cleaned. Then the rod body drives the pipe body and the rubber scraping plate to rotate, the rubber scraping plate scrapes off caked raw materials, then the inner wall of the drying tower body is washed clean during rotation of the spray head, and the cleaning effect is good.

The invention relates to the technical field of hemoglobin extraction equipment, and particularly discloses a goose hemoglobin active peptide separation and extraction method and device, linkage of three functions of centrifugation, lifting and stirring is realized through single motor driving, separation stability is ensured in combination with a ratchet-pawl transmission mechanism, and multistage membrane separation is coupled through lifting motion of a separation cylinder, so that the separation efficiency is improved. The device integrates an ultrasonic module, a temperature control module and a PH adjusting module, so that the whole-process integrated operation is realized, and the technical bottlenecks of large activity loss and low efficiency of the traditional method are solved.

The application belongs to the technical field of biosensors and provides an electrochemical biosensor for detecting ochratoxin A based on DNA tetrahedron, which comprises an A-P probe, a gold electrode with a modified capture probe CP, a circular template CT, phi 29 polymerase, dNTPs, Mg 2+ , hemoglobin, K + , H2O2; the A-P probe is obtained by hybridization of an aptamer Apt and a primer P; the nucleotide sequences of the aptamer Apt, the primer P, the capture probe CP and the circular template CT are shown as SEQ ID NO: 1-4; the 5' end of the capture probe CP is modified with SH. The sensor has a simple preparation method, stable performance and is suitable for the detection of OTA in food and environment; the process cost of the preparation process is low, the performance is stable, the electrode has good repeatability and is suitable for the requirements of cheapness in industrialization.

The application provides a glycated hemoglobin dissociation reagent and application thereof, and belongs to the technical field of biological detection. The dissociation reagent comprises 10-50 mM Tris buffer, 0.2-0.5 M ammonium chloride, 0.5%-1.0% (v / v) triton X-100, 0.2 wt%-1.0 wt% BSA and 0.02-0.2 M sodium chloride. When the dissociation reagent is used to dissociate a whole blood sample, the hemoglobin can be dissociated by mixing the dissociation reagent with the whole blood sample for 20-60 s, and a clear and transparent solution is obtained. The dissociation reagent can be used to prepare a kit for dissociating or / and detecting glycated hemoglobin. The glycated hemoglobin obtained by using the dissociation reagent can be directly used for fluorescence immunoassay, the interference of the color of hemoglobin itself on immunochromatographic detection is avoided, and the sensitivity is high and the repeatability is good.

Provided is a method for measuring glycated hemoglobin in a sample containing hemoglobin and plasma, the method including reacting glycated hemoglobin in a sample containing hemoglobin and plasma, a proteolytic enzyme, and a fructosyl peptide oxidase to generate hydrogen peroxide, and measuring the generated hydrogen peroxide, wherein the reaction is performed in the presence of ferrocyanide and a ferrocene derivative.

The invention relates to the technical field of deep learning, in particular to an extracorporeal circulation data analysis method and system based on deep learning, and the method comprises the following steps: collecting pump rotating speed, pump flow, arterial perfusion pressure, arteriovenous blood oxygen saturation, hemoglobin and lactic acid, carrying out the time alignment, completing the time sequence coding, and forming state characterization; the method comprises the following steps: correcting a state evolution direction by combining a relationship between oxygen delivery and oxygen extraction, introducing a lactic acid change trend to constrain time sequence consistency, constructing a circulating resistance matching perfusion capability according to flow and pressure, continuously correcting a state change direction, and generating an operation state analysis result. Oxygen delivery and oxygen extraction constraints are introduced to correct state evolution, a lactic acid trend is combined to strengthen time sequence consistency, resistance constraints are formed by perfusion pressure and flow, perfusion capacity changes are continuously corrected, and nonlinear state expression stability and overall interpretation coherence are improved.

The invention discloses application of polymerized hemoglobin, carbon-oxygen polymerized hemoglobin and a preparation method of the carbon-oxygen polymerized hemoglobin. Polymeric hemoglobin can be used for preparing medicines for treating sepsis and complications thereof.

Systems, devices, and methods for performing transabdominal fetal oximetry and / or transabdominal fetal pulse oximetry using physiological characteristics and / or calibration factors can receive a physiological characteristic of a pregnant mammal and determine one or more potential effects of the physiological characteristic on the behavior of a light signal projected into the abdomen of the pregnant mammal. Then, in response to the effects, a calibration factor for the light signal can be determined. Then, the calibration factor can be used to calibrate fetal detection electronic signals so that levels of fetal hemoglobin oxygen saturation can be determined.

To provide a device and a method for easily hemolyzing / diluting puncture blood even is the device is an A1c measuring device using the HPLC method.SOLUTION: Glycosylated hemoglobin (A1c%) is measured by a chip set that is formed of a conical or pyramid-shaped chip made of resin that can suck up puncture blood by a capillary phenomenon, a container that can store the chip, and a lid body that can seal the container, and can collect the puncture blood and hemolyze and dilute the blood, the chip set capable of collecting puncture blood and hemolyzing and diluting the blood, wherein the container has an inner diameter larger than the maximum outer diameter of the chip by 0.5 to 5 mm, and the container has therein a flange that has a columnar shape having a height allowing storage of the chip and is at a position 5 to 15 mm from a top face of the container, and a method for collecting puncture blood and hemolyzing / diluting the blood by using the chip.SELECTED DRAWING: Figure 7

This utility model relates to the field of comprehensive utilization technology of livestock and poultry blood, and discloses a device for extracting hemoglobin from livestock and poultry blood. The device includes a reaction vessel with an inlet at the top and an outlet at the bottom. An internal stirring shaft with several shearing blades is installed on the stirring shaft. A hollow jacket for condensation is provided on the outer wall of the reaction vessel. Several ultrasonic generators are detachably mounted on the reaction vessel. Several connecting pipes are connected through the reaction vessel, with a positioning sleeve with a sealing groove at the end of each connecting pipe and a sealing ring fitted on the positioning sleeve. The ultrasonic generators are sealed to the reaction vessel body via an installation kit. This utility model has a simple structure, compact design, and is easy to use. The ultrasonic generators are detachably mounted on the reaction vessel body and sealed by the installation kit, improving the processing efficiency of livestock and poultry blood, ensuring thorough cell disruption, and facilitating hemoglobin extraction. Simultaneously, the hollow jacket on the outside of the reaction vessel for cooling and condensation effectively reduces the temperature rise caused by the operation of the ultrasonic generators.

The utility model discloses a pig blood cell protein powder raw material premixing homogenizer which comprises a high-pressure tank body, the upper end of the high-pressure tank body is fixedly connected with a defoaming agent box, the surface of the defoaming agent box is connected with a round rod in a sliding mode through a through hole, one end of the round rod is fixedly connected with a round block, and the other end of the round rod is fixedly connected with a push plate. And scales are processed on the surface of the defoaming agent box. Through the arrangement of the high-pressure tank body, the defoaming agent box, the round rod, the push plate, the round block and the hose, when a defoaming agent needs to be added into a raw material in the high-pressure tank body, an operator pulls the round block, the round block drives the round rod to move, and the round rod drives the push plate fixed at the other end to move; through the mode, an operator can quickly add a defoaming agent solution in a proper proportion into the high-pressure tank body to be mixed with raw materials, so that the condition that the premixing effect of the pig blood cell protein powder raw materials is poor is avoided, and the working effect of the premixing homogenizer is improved.

The application belongs to the technical field of microorganisms, discloses a Pseudomonas putida and application of the Pseudomonas putida as fish probiotics, and specifically discloses a Pseudomonas putida Pseudomonas putida CD, the strain has strong fat utilization capacity, can produce various beneficial extracellular metabolites, can promote fish lipid, carbohydrate and protein metabolism and weight gain, and can also improve the iron content and hemoglobin content in fish tissues. The Pseudomonas putida strain CD has good biological safety and has broad development prospects in the application as fish probiotics.

The invention discloses a compound composition based on an enzymolysis technology as well as a preparation method and application thereof, and belongs to the technical field of health food. The invention discloses a compound composition based on an enzymolysis technology. The compound composition is prepared from the following raw materials in parts by weight: 30-45 parts of radix polygonati officinalis powder, 20-35 parts of fructus lycii powder, 10-20 parts of sea cucumber enzymatic hydrolysate, 10-25 parts of colla corii asini enzymatic hydrolysate, 3-5 parts of collagen peptide, 5-8 parts of jujube powder and 4-8 parts of hawthorn fruit powder. The compound composition based on the enzymolysis technology has the effects of increasing the number of red blood cells and hemoglobin, promoting hematopoiesis, improving anemia of zebrafish and improving immunity.

The present invention provides a drying and collecting device for blood protein powder, which relates to the field of pig blood powder production. The drying and collecting device for blood protein powder includes a main shell, an air heating structure, an atomizing structure, and a feeding mechanism. A first hot air port, a second hot air port, and a spray head are provided in the inner cavity of the main shell; the first hot air port and the second hot air port are respectively arranged on opposite side walls of the main shell, and the airflow direction of the first hot air port is parallel to the airflow direction of the second hot air port and is staggered to form a vortex airflow zone in the inner cavity of the main shell; the spray head is arranged at one axial end of the vortex airflow zone, and the main shell is also provided with a discharge port located at the other axial end of the vortex airflow zone, and the feeding mechanism is installed at the discharge port. The mist enters the vortex airflow zone and is fully contacted and mixed with the hot air. The mist generates a synchronous vortex motion as the hot air moves, which prolongs the heating time of the mist in the inner cavity of the main shell, resulting in a good drying effect and higher powder production efficiency.

1. The name of the design product: hemoglobin analyzer. 2. The use of the design product: for detecting and analyzing hemoglobin in blood. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

This application relates to a cream for promoting pet hair growth and its preparation method, belonging to the technical field of pet biomedicine. It comprises the following raw materials in weight percentages: microencapsulated fish oil 8%-10%; hemoglobin peptide 6%-12%; silkworm pupa protein powder 3%-5%; hydrolyzed chicken liver powder 2%-5%; yeast extract 1%-3%; rosemary extract 0.005%-0.01%; and antioxidant 0.1%-0.4%. The hemoglobin peptide is selected from one or more of MLL peptides and WDL peptides. The amino acid sequence of the MLL peptide is methionine-leucine-leucine; and the amino acid sequence of the WDL peptide is tryptophan-aspartic acid-leucine. This application has synergistic and long-term stable effects, is suitable for dogs, cats, and other pets, is safe with no side effects, and can be mass-produced.

The invention relates to a metal organic framework nano-enzyme aerogel / DNA detection liquid as well as a preparation method and application thereof, and belongs to the technical field of aerogel. The preparation method of the detection liquid comprises the following steps: adding a cross-linking agent into a polymer matrix solution, stirring, adjusting the pH value to 3-7, adding a Prussian blue modified metal organic framework, stirring, standing, freezing, and drying to obtain the metal organic framework nano-enzyme aerogel, then incubating the metal organic framework nano-enzyme aerogel and a heme / G quadruplex DNA solution together for 0.5-6 hours, taking out the aerogel, and taking the residual solution as a detection solution. The detection solution not only retains the enzyme activity, but also is more stable as a color developing solution, the absorbance cannot be continuously increased along with time, the problem that a color developing solution system is unstable in the process of detecting the antioxidant by a colorimetric method is solved, and the accuracy of antioxidant detection is further improved.

Provided is a probe unit used for measuring hemoglobin dynamics inside a subject. The probe unit is provided with: a holder having flexibility and having a shape curved such that one end and the other end face each other; a first probe attached to the one end of the holder, the first probe having a first surface on which a first incidence / emission unit for performing incidence / emission of light on the subject is exposed, and on which a light-blocking member is detachably attached so as to surround the first incidence / emission unit; and a second probe attached to the other end of the holder, the second probe having a second surface on which a second incidence / emission unit for performing incidence / emission of light on the subject is exposed, and on which a light-blocking member is detachably attached so as to surround the second incidence / emission unit.

The utility model discloses a separation and extraction device for goose hemoglobin nutritional value research, and relates to the technical field of separation and extraction devices, the separation and extraction device comprises an extraction tank, the center of the top of the extraction tank is provided with a driving part, and the driving end of the driving part is provided with a liquid extraction cylinder; by starting the first electric push rod, the driving end of the first electric push rod extends to drive the liquid extraction barrel and the liquid suction pipe to descend and be completely inserted into a goose hemoglobin solution layer, and then by starting the second electric push rod, the driving end of the second electric push rod sequentially shortens and extends to drive the piston piece to move up and down in the liquid extraction barrel; goose hemoglobin can be sucked into the liquid extraction cylinder through the liquid suction pipe and the one-way feeding valve and then discharged out of a designated position outside the liquid extraction cylinder through the one-way discharging valve, manual participation of personnel is little in the process, the problem that the goose hemoglobin solution is scattered due to the fact that manual operation of the personnel is prone to shaking can be avoided, and stability is improved.