350 results about "Bile fluid" patented technology

The invention relates to the technical field of biological medicines, and discloses a high-activity lactobacillus rhamnosus probiotic microcapsule, which comprises the following components in parts by weight: lactobacillus rhamnosus: each gram of formula contains 1010 CFU; bifidobacterium: each gram of the formula contains 109 CFU; 10% to 20% of sodium alginate; 5%-15% of chitosan; 3%-8% of hydroxypropyl methyl cellulose; 3%-7% of pectin; 5% to 10% of fructo-oligosaccharide; 5%-10% of inulin; 0.1%-0.5% of vitamin C; and 0.1%-0.3% of vitamin E. Through double-layer and three-layer embedding technologies (such as compound use of sodium alginate and chitosan and compound use of pectin and gelatin), the tolerance of the probiotics in gastric acid and bile environments is remarkably improved, the probiotics are effectively protected through a multi-layer embedding structure, the survival rate of the probiotics in the gastric environment reaches up to 90%, and the release rate in the small intestine exceeds 75%.

The invention discloses a filtering device for reinfusion after external drainage of bile in the hepatobiliary surgery department, and belongs to the technical field of medical instruments. The filtering device comprises a drainage mechanism, a stepped filtering mechanism and a reinfusion mechanism. The stepped filtering mechanism is used for filtering bile; the stepped filtering mechanism is detachably connected with the drainage mechanism and the feedback mechanism. The stepped filtering mechanism comprises a filtering carrier, a filtering cavity and a pumping mechanism used for pumping bile to the filtering cavity are arranged in the filtering carrier, a primary screen, a hollow fiber membrane and a hydrophilic gel filtering membrane are sequentially arranged in the filtering cavity from top to bottom, and a cleaning mechanism used for cleaning the primary screen is arranged on one side of the primary screen. An ultrasonic vibration module for cleaning attachments on the hollow fiber membrane is arranged on one side of the hollow fiber membrane. By means of the intelligent design and the multi-stage filtering mechanism, the bile feedback efficiency and safety are remarkably improved, and the infection risk is reduced.

The invention belongs to the technical field of in-vitro cultivation of calculus bovis, and particularly relates to a method for in-vitro cultivation of calculus bovis. According to the invention, firstly, the escherichia coli is subjected to bile domestication and ray induced mutation, a high-activity oxgall-resistant bezoar production engineering bacterium E.coli-NH01 is obtained through screening, a method for in-vitro cultivation of bezoar by using the engineering bacterium E.coli-NH01 is provided, the prepared bezoar meets the pharmacopoeia standard, the production efficiency of in-vitro cultivation of bezoar is improved, and the production cost is reduced. And the production cost is reduced, the overall forming period is shortened, and the key that precious traditional Chinese medicinal materials are popular can be achieved.

The invention provides cholate-tolerant yellow bacteria and application thereof, and belongs to the field of calculus bovis cultivation. According to the invention, a cholate-tolerant yellow-causing bacterium is obtained through screening, the cholate-tolerant yellow-causing bacterium is classified and named as Escherichia coli NCD04, the bacterial strain is preserved in China Center for Type Culture Collection on August 23, 2024, and the preservation number of the bacterial strain is CCTCC NO: M 20241834. The xanthogenic bacterium provided by the invention is derived from healthy oxgall, has excellent oxgall resistance, is high in activity of produced beta-glucuronidase and high in direct bilirubin conversion rate, can accelerate conversion of bile to calculus bovis, and is used for production of in-vivo or in-vitro artificial calculus bovis.

The invention relates to the field of bile monitoring and analysis, in particular to a dynamic bile monitoring and analysis method and device based on real-time image recognition. The method comprises the following steps: continuously collecting a bile monitoring image sequence of a drainage bag of a patient, and carrying out global image resolution optimization and multi-frame color drift analysis to obtain a multi-time-point bile color evolution sequence; performing comprehensive bile physical state vector modeling according to the bile monitoring image sequence, performing personalized bile state characteristic evolution, and constructing a bile color-property comprehensive characteristic spectrum; and performing deep color component visual detection based on the multi-time-point bile color evolution sequence, performing pathological concentration change mining, and constructing a concentration anomaly evolution model. According to the method, the real-time bile state characteristics of the patient are accurately analyzed based on precision visual identification, the risk level and deterioration prediction are combined, the dynamic adjustment of the precise early warning time point is realized, and the response speed and the early warning accuracy are improved.

1. The name of the product of this design: bile duct drainage tube. 2. Purpose of the product of this design: A disposable soft catheter used for drainage of bile after common bile duct incision and exploration. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention discloses a method for cultivating high-quality calculus bovis by utilizing flora, and belongs to the technical field of in-vitro cultivation of calculus bovis, the method comprises the steps of treating natural ox bile, preparing bacteria, fermenting and obtaining a finished product, in the fermentation step, adding a first bacteria solution and a third bacteria solution into a first mixed solution formed by mixing vitamin C, rosemary and the natural ox bile, adding a second bacterial solution to obtain a second mixed solution, slowly shaking and rotating the second mixed solution for 2-4 hours in an environment of 37 DEG C, then adding the second bacterial solution to obtain a third mixed solution, and slowly shaking and rotating the third mixed solution for 8-10 hours in an environment of 37 DEG C; the mass ratio of the first bacterial liquid to the third bacterial liquid to the second bacterial liquid to the first mixed liquid is (0.8-1.2): (0.7-0.9): (0.4-0.6): (90-110). According to the method, the types of the bacterial liquid in the ox gall are adjusted and matched with each other, and the bacterial liquid is close to a complex stone-forming environment in the ox gall as far as possible, so that the components of the calculus bovis are enriched and balanced, the utilization rate of the ox gall is increased, the synergistic effect of the components can be fully exerted, and the effect of the calculus bovis is closer to that of natural calculus bovis.

The invention relates to application of 1, 2, 3, 4, 6-O-pentagalloylglucose in preparation of a medicine for resisting cholestatic liver diseases, and belongs to the technical field of medicinal chemistry. The 1, 2, 3, 4, 6-O-pentagalloylglucose provided by the invention can be used for promoting bile acid excretion by reducing WDR6 protein expression. In-vivo and in-vitro experiments prove that the 1, 2, 3, 4, 6-O-pentagalloylglucose can be used for remarkably relieving the symptom of the cholestatic liver disease. In addition, the 1, 2, 3, 4, 6-O-pentagalloylglucose has no obvious toxic or side effect, and has no obvious influence on the liver function and the kidney function. The 1, 2, 3, 4, 6-O-pentagalloylglucose has a wide anti-cholestatic liver disease spectrum, and is suitable for various cholestatic liver diseases, such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and the like.

The invention discloses an application of probiotics in preparation of a medicine for preventing and / or treating cholestatic liver diseases. The probiotics are selected from one or more of plant lactobacillus Lp-G18, bifidobacterium longum subsp. Longum BL-G301, lactobacillus reuteri LR-G100 and lactobacillus johnsonii LJ-G55. Preferably, the cholestatic liver disease is primary biliary cholangitis.

The present invention relates to antisense oligonucleotides (AONs) that can mediate RNA editing by binding to a target RNA nucleic acid molecule, preferably an RNA transcript molecule, in a cell and recruiting an endogenous deaminating enzyme in the cell to deaminate a target adenosine in the target RNA molecule to an inosine. The target RNA molecule is a transcript molecule form the SLC10A1 gene that encodes the Na+ / Taurocholate Co-transporting Polypeptide (NTCP), and the target adenosine is the adenosine in the GAC codon coding for aspartic acid (D) at position 24 of the NTCP protein. The deamination of the adenosine changes the amino acid to a glycine (G). The RNA editing of the adenosine will result in a loss-of-function of the NTCP protein, which will result in lowered uptake of bile acids from the portal circulation into the liver, thereby lowering the risk of suffering from disorders related to bile accumulation in the liver.

The invention discloses Pediococcus pentosaceus G41, which is separated from rumen fluid of healthy adult dairy cows in a certain cattle farm in Changchun, has the advantages of high growth speed and strong acid production capacity, and can effectively relieve cholestatic liver injury. Experiments prove that the Pediococcus pentosaceus G41 reduces the activity of serum AST, ALT and GDH of a mouse with cholestatic liver injury, reduces the content of total bile acid in blood and liver, increases the content of total bile acid in excrement, and improves cholestatic and dirty injury caused by cholestatic.

The invention relates to a construction method and application of a bile acid fingerprint spectrum in bile, and relates to the technical field of traditional Chinese medicine detection. The construction method comprises the following steps: preparing a reference substance solution: weighing at least two of taurocholic acid, taurodeoxycholic acid, glycocholic acid, cholic acid and glycodeoxycholic acid reference substances, and preparing the reference substance solution; preparing a test sample solution, namely filtering bile, taking filtrate, heating in a gradient manner, drying and grinding to obtain a test sample, and preparing the test sample solution; and constructing a fingerprint spectrum: respectively injecting the reference substance solution and the test solution into a high performance liquid chromatograph, and determining under a predetermined liquid phase condition to construct the bile acid fingerprint spectrum. The construction method can be used for fully and effectively separating and identifying various bile acid components in the bile, can be used for simultaneously detecting and measuring the various bile acid components in the bile, and has important significance in the aspects of quality control, authenticity identification, basic research on pharmacodynamic substances and the like of the bile.

The invention relates to the technical field of medical instruments, in particular to an intelligent bile flow monitoring T tube which comprises a microprocessor and a T tube body, a pressure sensor is arranged in the T tube body, the T tube body is formed by communicating a transverse tube and a longitudinal tube, the two ends of the transverse tube are close to the bile duct and the intestinal tract of the liver respectively, and drainage is conducted to the outside from the end of the longitudinal tube. A first flow sensor is arranged on the transverse tube close to the liver bile duct to measure the total flow of bile, a second flow sensor is arranged close to the intestinal tract to measure the amount of bile flowing into the intestinal tract, and a third flow sensor is arranged in the longitudinal tube to measure the flow of bile discharged out of the body. The microprocessor collects and analyzes sensor data through the information collecting and processing module so as to calculate bile flow and pressure, and judges the bile flow direction condition when the third flow sensor data is abnormal. The bile monitoring precision can be improved, in-vitro drainage amount abnormity can be quickly diagnosed, the postoperative management efficiency is enhanced, the complication risk is reduced, the postoperative safety of a patient is improved, and the function and reliability of a bile drainage system are improved by means of an innovative technology.

The invention relates to the technical field of intelligent medical care, and discloses a drainage port nursing recommendation method and system for a patient with bile leakage. The system comprises a data acquisition module used for acquiring bile drainage data and state data of skin around a drainage port in real time; the cloud decision module is internally provided with a nursing scheme recommendation model associated with a bile leakage nursing knowledge graph, and is used for carrying out fusion analysis on the multi-modal data and generating a personalized nursing plan; the local execution terminal is used for receiving and displaying the nursing plan and guiding nursing personnel to execute and record actual nursing operation data; and the closed-loop feedback module is used for returning the actual execution data and the post-nursing state data so as to optimize the nursing scheme recommendation model and the bile leakage nursing knowledge graph. The technical problems that in traditional nursing, evaluation is subjective, decision-making depends on experience, execution is not standard, and knowledge is difficult to accumulate are solved, and standardization, individuation and continuous self-optimization of bile leakage drainage opening nursing are achieved.

A surgical instrument for percutaneous transhepatic choledochoscope diagnosis and treatment is used for establishing a first-stage surgical channel of the percutaneous transhepatic choledochoscope and sinus tract forming of staging surgery, and the surgical instrument system is composed of a surgical working channel sheathing canal and a sinus tract forming drainage tube. The operation working channel sheathing canal is provided with a straight pipe, a bent pipe, an adjustable bending design and an adjustable bending device so as to adapt to all levels of bile ducts to walk, is provided with an anti-squashed pipe body or a variable-diameter material or a variable-diameter device pipe body, a controllable negative pressure connector, an endoscope insertion channel, a sealing cap and an instrument channel, and is provided with an expansion pipe, so that the sheathing canal can be conveniently and smoothly placed into the biliary tract; the sinus tract forming drainage tube body is of a reducing structure, adapts to the volume of a bile duct cavity, is provided with a pigtail-shaped anti-falling device, a fixing line and other anti-falling devices, reduces falling of the drainage tube, is provided with a side hole, can achieve the bile drainage function, is provided with a fixed Luer taper and a movable Luer taper, facilitates imbedding of the sinus tract forming drainage tube in different operation scenes, and is convenient to use. The device is used for improvement and smooth implementation of percutaneous transhepatic choledochoscope surgery.

The invention discloses a biliary drainage reinfusion device which comprises a nasobiliary duct, a drainage bag, a sealing cylinder, a heating mechanism, a filtering mechanism and a reinfusion tube, the drainage bag is arranged at the output end of the nasobiliary duct, the sealing cylinder is connected to the output end of the drainage bag, and the heating mechanism and the filtering mechanism are arranged in the sealing cylinder. And the feedback pipe is connected to the output end of the sealing cylinder and is used for feeding back the heated and filtered bile into the body of the patient. By arranging the heating mechanism and the filtering mechanism, bile which is drained and returned is heated and filtered, impurities such as tissue fragments in the bile are removed and intercepted, the bile is prevented from entering the body of a patient, meanwhile, pipeline blockage caused by thick bile is avoided, discomfort caused by the fact that low-temperature bile enters the human body is reduced by heating the bile, and the treatment effect is good. The activity of enzymes in the bile is maintained. And by arranging the feedback tube, the integral closed drainage feedback device is realized, and the pollution is reduced.

Provided are a substance and method for improving intestinal health and homeostasis, and the nutrition and development of a subject. The substance is an odd carbon fatty acid. Specifically, provided is the use of an odd carbon fatty acid in the preparation of a preparation or drug for increasing the protein expression abundance of related tight junction proteins of a subject, reducing the content of a corticotropin-releasing hormone in the intestinal tissue of a subject, improving or enhancing the intestinal mechanical barrier of a subject, maintaining the intestinal immune homeostasis of a subject, promoting the intestinal development of a subject, maintaining the energy homeostasis in intestinal cells of a subject, improving intestinal energy metabolism, promoting the development and metabolism of muscle tissue in a subject, promoting the development and metabolism of adipose tissue in a subject, reducing allergic reactions of the body and the intestinal tract of a subject, reducing the insulin resistance in a pregnant subject, controlling the blood glucose level in a pregnant subject, preventing gestational diabetes mellitus, preventing or improving intrahepatic cholestasis in a pregnant subject, preventing or treating diseases caused by Helicobacter pylori bacteria in a subject, etc.

The invention relates to a pharmaceutical formulation, e.g. a paediatric formulation, of odevixibat, which comprises a plurality of small particles. The formulation may be used in the treatment of liver diseases such as bile acid-dependent liver diseases, and particularly cholestatic liver diseases such as biliary atresia, progressive familial intrahepatic cholestasis (PFIC), Alagille syndrome (ALGS) and paediatric cholestatic pruritus. The invention also relates to a process for the preparation of the pharmaceutical formulation.

The utility model provides a self-discharging type double-helix biliary stent, and belongs to the technical field of medical drainage catheters. Comprising a stent body, and the stent body comprises a connecting pipe, a first spiral pipe and a second spiral pipe; the connecting pipe is used for fixedly connecting the first spiral pipe and the second spiral pipe; the first spiral tube is mounted on one side of the connecting tube and used for draining bile; the second spiral pipe is installed on the side, away from the first spiral pipe, of the connecting pipe. Compared with an existing double-pigtail stent or a self-discharging type biliary tract spiral stent, the spiral structure of the two sets of spiral tubes can better adapt to the physiological form of the biliary tract, stable fixation is formed, the risk that an original stent with one end being of a vertical structure possibly pierces the intestinal wall is avoided, and the intestinal tract can be more stably fixed. Due to the arrangement of the self-discharging double-helix biliary stent, convenience is provided for taking out the stent subsequently.

The utility model relates to the technical field of medical instruments, in particular to a multifunctional biliary tract drainage tube with double-cavity sacculus auxiliary expansion through a PTCD (percutaneous transluminal compact disc) way, which comprises a drainage tube, a sacculus expansion tube group, a water injection tube and a sacculus, the fixing shell set comprises a drainage tube fixing shell and a water injection tube fixing shell arranged on the periphery of the drainage tube fixing shell, the drainage tube fixing shell is connected with the drainage tube, and the water injection tube fixing shell is connected with the water injection tube; the internal and external intercommunication window is communicated with a first area on the drainage tube and a second area, corresponding to each other, on the water injection tube, so that bile outside the water injection tube flows into the drainage tube through the internal and external intercommunication window. The multifunctional biliary tract drainage tube for assisting expansion through the PTCD way double-cavity balloon integrates biliary tract expansion and bile drainage, operation is reduced, and operation cost can be greatly reduced.

The disclosure herein relates to the development and production of novel antibodies and antigen binding fragments thereof that bind TL1 A and that are useful in the treatment, prevention and diagnosis of a disease, disorder or inflammation including, for example, autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, systemic lupus erythematosus, asthma, ulcerative colitis, Crohn's disease, psoriasis, primary biliary cirrhosis, primary biliary cholangitis, ankylosing spondylitis, and fibrosis including intestinal fibrosis, pulmonary fibrosis, and liver fibrosis. Some of the elements of final antibody structure being designed de novo by a computer system and its data training set without reference to a specific reference molecule.

The invention provides a strain of high-temperature-resistant and inflammation-relieving Witzia ciliaris and an application thereof, the high-temperature-resistant and inflammation-relieving Witzia ciliaris is Witzia ciliaris CN985 and is preserved in the China Center for Type Culture Collection (CCTCC), the preservation date is April 7, 2024, and the preservation number is CCTCC NO: M 2024641. The invention further provides a preparation method of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain. The invention provides a brand new strain of Witzia ciliaris CN985, which is resistant to high temperature, has better acid resistance and bile resistance, and has no hemolysis risk when being applied to a human body. The Witzia coagulans CN985 has excellent antibacterial performance, and especially can significantly inhibit streptococcus pyogenes, salmonella enteritidis and / or group B streptococcus; besides, experimental results show that the Witzia ciliaris CN985 can relieve enteritis, improve the immunity of the organism and relieve pharyngitis, and especially when the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 are combined for use, the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 have a synergistic interaction effect, so that the relieving effect on enteritis can be remarkably improved.

The invention belongs to the technical field of medicine, and provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation and application thereof, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of astragalus membranaceus, 20-30 parts of phaseolus calcaratus, 5-10 parts of radix rehmanniae, 10-20 parts of endothelium corneum gigeriae galli, 10-15 parts of hawthorn and 5-20 parts of fingered citron. The traditional Chinese medicine composition disclosed by the invention has an exact curative effect on improving the liver function, total bile acid metabolism and the like of intrahepatic cholestasis in the gestation period. Clinical, animal and cell test results show that the traditional Chinese medicine composition can effectively improve symptoms and signs of intrahepatic cholestasis in the gestation period.

The invention relates to application of mesenchymal stem cells of overexpressed Numb genes in preparation of drugs for treating chronic liver diseases. The invention also provides a mesenchymal stem cell modified by genetic engineering, and the mesenchymal stem cell modified by genetic engineering is a mesenchymal stem cell of an overexpressed Numb gene. The invention provides a novel human umbilical cord mesenchymal stem cell (hUC-MSC) for treating chronic and acute hepatic failure, hepatic fibrosis and liver cirrhosis. The hUC-MSCs overexpressing the Numb gene can inhibit liver inflammatory response and hepatic fibrosis progress in a dose-dependent manner; biliary duct reaction is inhibited in a dose-dependent manner, and cholestasis is improved; the liver cell proliferation can be promoted in a dose-dependent manner, and the content of serum albumin is increased. And the treatment effects are better than those of the same dose of hUC-MSCs. The hUC-MSCsNumb-OE can be directly used as a cell for treating chronic and acute hepatic failure, hepatic fibrosis and cirrhosis, and also can be used as a tool for screening biological or chemical medicines for treating hepatic fibrosis and cirrhosis.

The invention relates to the technical field of bioengineering, in particular to a preparation method of a probiotic and exosome preparation applied to immunoregulation. The probiotics and the umbilical cord stem cell exosome are combined for use, the immune regulation effect is enhanced from multiple targets and multiple ways, the immune function of the body is improved, the exosome carries a specific molecular marker and acts on immune cells in a targeted mode, precise immune regulation is achieved, and the preparation is in an oral form and convenient to use; the exosome is extracted from umbilical cord stem cells, has no pathogenicity and immunogenicity, and is low in adverse reaction risk after being used for a long time, and the prepared combined preparation can be used for treating and preventing various immune-related diseases, and also can be used for daily conditioning of people with low immunity and improving the body resistance; meanwhile, the combined preparation adopts micro-capsule embedding, so that the probiotics can be effectively protected from gastric acid and bile erosion, the survival rate and colonization efficiency of the probiotics in intestinal tracts are improved, the immunoregulation effect is further enhanced, and the combined preparation is convenient to store and transport and has a good application prospect.

The invention belongs to the technical field of biology, and particularly relates to a small molecule peptide composition and method for regulating natural calculus bovis production. The small molecule peptide aiming at a key target spot is designed by deeply researching secretion and metabolism of ox bile. The action mechanism covers biliary secretion stimulation, component optimization, bezoar key enzyme activity promotion and immune response regulation. A chemical synthesis or biotechnology means is adopted for preparation, and the dosage is determined according to cattle conditions during application. The safety is strictly evaluated, the yield of the natural calculus bovis can be obviously improved by 65%, the quality is also greatly improved, the effective components are increased, the impurities are reduced, the drug effect is enhanced, a new efficient and safe way is opened up for the production of the natural calculus bovis, and the method has a wide application prospect.

The present invention relates to the technical field of probiotics, in particular to a Lactiplantibacillus plantarum GOLDGUT-LP618 having a function of resisting Salmonella infection and application thereof. The Lactiplantibacillus plantarum GOLDGUT-LP618 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28399. The strain has high resistance to acid and bile salt and can adapt to the digestive tract environment. The strain can inhibit Salmonella infection, relieve diarrhea, inflammation and intestinal damage caused by Salmonella infection, and promote intestinal health. The strain can be used for preparing functional foods, dietary supplements or drugs that can resist Salmonella infection and improve diarrhea and inflammation caused by Salmonella infection, and has good application prospects.

The invention relates to the technical field of biology, and particularly discloses a gene Panel sequencing method for intrahepatic cholestasis in a gestation period, which comprises the following steps: collecting saliva, performing DNA extraction and purification on a sample, breaking the purified sample, treating the broken sample to obtain a supernatant A, performing linker connection and purification on the supernatant A to obtain a supernatant B, and sequencing the supernatant B to obtain the gene Panel of intrahepatic cholestasis in a gestation period. The invention relates to a Panel detection technology for detecting 186 cholestasis genes covering bile acid metabolism, which comprises the following steps: preparing a supernatant B, carrying out pre-PCR and purification treatment on the supernatant B to obtain a pre-PCR product, carrying out liquid phase hybridization and capture, configuring a PCR reaction system, carrying out Post-PCR reaction and purification to obtain a supernatant C, quantifying the supernatant C, screening ICP susceptible genes through mixed sample sequencing, collecting DNA (Deoxyribonucleic Acid) through a saliva sampling mode, and detecting the 186 cholestasis genes covering bile acid metabolism. Other hereditary intrahepatic cholestasis diseases can be excluded, and ICP genetics susceptibility genes are defined.

The invention discloses a postoperative recurrence monitoring system and method for bile liquid biopsy, and relates to the technical field of medical detection, and the method comprises the following steps: obtaining medication data, bile liquid data and gene data of a target object; preprocessing the medication data and the bile liquid data to generate a sampling interference index sequence, and further performing weighted fusion on the gene data by the sampling interference index sequence to obtain a mutation load index of each gene detection time point; and within the time sequence range of the gene data, performing sliding window analysis on the sampling interference index sequence to generate an abnormal chain marker sequence. According to the method, the time sequence mismatch degree is accurately quantified by constructing a time difference matrix, and a weight distribution mechanism is dynamically adjusted in combination with medication volatility, so that the generation process of the sampling interference index can adaptively reflect the influence of medication mode change on the sampling quality; the problem of interference evaluation deviation caused by mismatching of medication data and bile sampling time is effectively solved.