5 results about "Anticonvulsant" patented technology

Relates to the technical field of medicines, provides keratin CF5, a preparation method, a pharmaceutical composition and application thereof, and particularly relates to keratin CF5, a nucleic acid molecule for coding the keratin CF5, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, and a preparation method of the keratin CF5. The invention relates to a keratin CF5-containing pharmaceutical composition and application of the keratin CF5, nucleic acid molecules, expression vectors, host cells or the pharmaceutical composition in preparation of antipyretic and analgesic, cough-relieving and phlegm-eliminating drugs, anticonvulsion, antiepilepsy, blood pressure lowering drugs, anti-inflammatory drugs and antiviral drugs, in particular to application of the keratin CF5, the nucleic acid molecules, the expression vectors, the host cells or the pharmaceutical composition in preparation of antipyretic and analgesic drugs.

The invention belongs to the technical field of medicines, and particularly relates to an N-propyl-4-phenylindole derivative as well as a preparation method and application thereof. The structure of the N-propyl-4-phenylindole derivative is as shown in the specification. The compound takes an indole ring as a parent nucleus, a phenyl substituent is introduced to the fourth site of the parent nucleus, a flexible n-propyl connecting chain is connected to the first site of the parent nucleus, the hydrophobic interaction with a receptor is enhanced through 4-phenyl, the overall physicochemical properties of molecules are adjusted, diversified alkaline amino fragments are flexibly connected through an N-propyl chain, and the compound is obtained. And the N-propyl-4-phenylindole derivative is obtained. Through the unique structure, strong H3 receptor antagonistic activity and anticonvulsion effect are achieved, and meanwhile, the compound has good safety and central nervous system penetrability and is expected to be developed into a new generation of high-efficiency and low-toxicity antiepileptic drug.

The invention provides a medicine pillow for regulating mind, liver, spleen, lung and kidney based on the theory of five mind of traditional Chinese medicine, and comprehensive regulation of mind stabilization, liver soothing, spleen transformation, lung and kidney qi absorption is realized by implanting a traditional Chinese medicine composition and cooperating with acupoint stimulation. Through clinical verification, the effective rate on insomnia, anxiety and chronic fatigue is greater than 85%. The tea is beneficial to resuscitation and intelligence development, improves learning and memory, and has improvement effects on calming, convulsion resistance, depression resistance, arteriosclerosis resistance, hyperlipidemia resistance, hypertension and cardiovascular and cerebrovascular diseases.

The invention relates to besylate salts of the compound of formula (I):Methods of preparing the salts, and their use as medicaments, in particular for sedative or hypnotic, anxiolytic, muscle relaxant, or anticonvulsant purposes is also described.

This application discloses succinimide derivatives in the field of organic chemistry, with the general structural formula shown in Formula V. During preparation, compound I reacts with compound II to yield compound III; compound III reacts with compound IV in the presence of a condensing agent to yield succinimide derivative V. The succinimide derivatives of this application can be used in the preparation of sedative, tranquilizing, nootropic, anticonvulsant, antiepileptic, antineuralgia, anti-anxiety, antidepressant, antidementia, and / or brain injury protective drugs.