4 results about "Bupropion" patented technology

This disclosure relates to dosage forms comprising bupropion hydrochloride, another salt form of bupropion, or the free base form of bupropion; dextromethorphan hydrobromide, another salt form of dextromethorphan, or the free base form of dextromethorphan, and a polymer. In some embodiments, the dosage form has no significant dose dumping of bupropion in the presence of ethanol in vitro. In some embodiments, the dosage form does not have a food effect for bupropion or dextromethorphan when taken with a high-fat meal in human subjects. Some embodiments include a method of treating a nervous system condition (such as depression, e.g., major depressive disorder, including treatment-resistant depression, agitation associated with Alzheimer's disease (or agitation associated with dementia of the Alzheimer's type), agitation associated with dementia, anxiety (or generalized anxiety disorder), neuropathic pain, or peripheral diabetic neuropathic pain) comprising, administering a dosage form described herein to a human being in need thereof.

This disclosure relates to a method of treating depression and / or reducing suicide risk, comprising administering a combination of about 90 mg to about 120 mg of bupropion chloride (or another molar equivalent of bupropion) and about 40 mg to about 50 mg of dextromethorphan hydrobromide (or another molar equivalent of dextromethorphan). This combination can be administered twice daily to individuals suffering from severe depression and scoring 3 or higher on the Suicide Proneness Item of the Montgomery-Aussberg Depression Rating Scale (MADRS-SI).

Dosage forms, drug delivery systems, and methods related to the sustained release of dextromethorphan or enhanced therapeutic effects are disclosed. Typically, bupropion or a related compound is administered orally to a human being treated with or who is being treated with dextromethorphan.

This disclosure relates to a method of treating depression and / or reducing suicide risk, comprising administering a combination of about 90 mg to about 120 mg of bupropion chloride (or another molar equivalent of bupropion) and about 40 mg to about 50 mg of dextromethorphan hydrobromide (or another molar equivalent of dextromethorphan). This combination can be administered twice daily to individuals suffering from severe depression and scoring 3 or higher on the Suicide Proneness Item of the Montgomery-Aussberg Depression Rating Scale (MADRS-SI).