18 results about "Anorectic" patented technology

Methods of treating one or more eating disorders including anorexia nervosa, bulimia, and related clinical syndromes in a subject in need thereof are described. In some cases, electric stimulation and / or one or more active agents are administered to a subject in need thereof to reduce or inhibit the activity of CeA PKC-δ neurons and ovBNST PKC-δ neurons in the brain of the subject. Preferably, the disclosed methods are effective to increase or excite the activity of the brain regions downstream of CeA PKC-δ neurons and ovBNST PKC-δ neurons including medial part of CeA and ventral lateral part of BNST.

Olmsted syndrome (OS) is a rare genodermatosis classically characterized by the combination of bilateral mutilating transgredient palmoplantar keratoderma (PPK) and periorificial keratotic plaques. The inventors obtained remarkable results with a treatment with a EGFR inhibitor (e.g. erlotinib) in 3 patients with Olmsted Syndrome and erythemalgia linked to different TRPV3 mutations. In less than 3 months, the drug induced a complete disappearance of the hyperkeratosis and the pain. Anorexia and insomnia disappeared with an improvement of the growth. Accordingly, the present invention relates to the use of EGFR inhibitors for the keratodermas.

The invention concerns methods for treating unwanted body weight loss, and / or medically undesired body weight loss, or eating disorders (such as anorexia nervosa), by administration of a leptin receptor agonist, such as metreleptin. The invention also relates to methods for increasing body weight in a subject in need of the treatment.

This invention relates to the field of chemical pharmaceutical technology, specifically to the application of sesquiterpenoid compounds in relieving nausea and vomiting. The sesquiterpenoid compounds of this invention are cypressin and its analogues, racemates, stereoisomers, tautomers, isotope-labeled compounds, solvates, polymorphs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof, having the following structures, wherein R1-R8 are as described in the claims and specification. These sesquiterpenoid compounds can reduce kaolin ingestion in pica rats and significantly alleviate nausea and vomiting symptoms induced by chemotherapeutic drugs such as cisplatin during tumor treatment. They can also relieve vomiting caused by gastrointestinal damage, inflammatory diseases, anorexia, etc. They can be used to prepare drugs for relieving / treating nausea and vomiting or to prepare foods that help protect the gastric mucosa.

The invention provides an innovative AN drug treatment strategy, and based on a prazosin targeted LC-NE neural circuit, the weight is increased and the AN symptom is improved by reducing LC-NE neuron over-excitation, restoring appetite and improving the anxiety state. The application is characterized in that: different from the traditional antidepressant or antipsychotic drug, the pazosin can directly regulate and control the feeding loop. The safety is high, clinical use experience exists, and indications can be directly expanded. Individual treatment schemes are provided and can be independently used or combined for treatment, and the curative effect is improved. The application is expected to provide a new thought and a new drug choice for AN treatment, and promote the research of the NE system in eating disorders.

The purpose of the present invention is to newly discover a transient receptor potential ankyrin 1 (TRPA1) agonist that exhibits an action for increasing the amount of food ingested, to provide a novel agonist of TRPA1, or to provide a novel active ingredient that exhibits an action for increasing the amount of food ingested or an action for improving anorexia. A compound having a specific fatty acid or a specific anthraquinone structure has an effect for activating TRPA1 and can be used as an active ingredient for increasing the amount of food ingested and / or improving anorexia.

The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating anorexia and weight loss, comprising a Bupleuri Radix extract. Specifically, the present invention provides a pharmaceutical composition having effects in preventing, ameliorating, or treating anorexia and weight loss, wherein a Bupleuri Radix extract increases ghrilin, which is a hormone that stimulates appetite, and decreases TPH1(I), which is a serotonin synthase. In addition, a health functional food for preventing or ameliorating anorexia and weight loss, comprising a Bupleuri Radix extract, can be developed, and the extract can be effectively used for the treatment and the development of therapeutic agents for anorexia induced by chemotherapy in the future.

The invention relates to the technical field of chemical medicines, in particular to application of sesquiterpenoids in relieving nausea and vomiting. The sesquiterpenoids disclosed by the invention are cedar wood alcohol with the following structure, an analogue of the cedar wood alcohol, a racemate of the cedar wood alcohol, a stereoisomer of the cedar wood alcohol, a tautomer of the cedar wood alcohol, a solvate of the cedar wood alcohol, a polymorphic substance of the cedar wood alcohol, a metabolite of the cedar wood alcohol, a metabolite of the cedar wood alcohol, a prodrug of the cedar wood alcohol or pharmaceutically acceptable salt of the cedar wood alcohol. The sesquiterpenoids can reduce kaolin intake of allotriophagia rats, and obviously alleviate nausea and vomiting symptoms generated when chemotherapeutic drugs such as cis-platinum are used for tumor treatment. And emesis caused by gastrointestinal injury, inflammatory diseases, anorexia and the like can be relieved. The compound can be used for preparing medicines for relieving / treating nausea and vomiting or preparing foods for assisting in protecting gastric mucosa. # imgabs0 #

The present invention relates to a composition for ameliorating or treating cachexia containing calcium lactate as an active ingredient, and a method for treating cancer cachexia in a subject, the method comprising a step of administering calcium lactate or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. The calcium lactate of the present invention acts as a Hif-1α inhibitor and exhibits an effect of suppressing body mass loss due to cancer, so that it can be used as a candidate substance for solving the problem of cancer cachexia and suggests a synergistic effect between a medical nutritional product focused on anorexia and malnutrition and a Hif-1α inhibitor.

In order to overcome the defects in the prior art, the invention provides a traditional Chinese medicine composition for treating cancerous anorexia, which is prepared from the following components in percentage by mass: 10 to 15 percent of poria cocos, 5 to 10 percent of codonopsis pilosula, 5 to 10 percent of radix glehniae, 5 to 10 percent of radix pseudostellariae, 5 to 10 percent of roasted astragalus membranaceus, 5 to 10 percent of roasted malt, 5 to 10 percent of roasted endothelium corneum gigeriae galli, 5 to 10 percent of potentilla discolor and 4 to 7 percent of roasted rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition is prepared from the following raw materials in percentage by weight: 4-7% of radix bupleuri, 4-7% of elsholtzia rugulosa, 2-5% of American ginseng, 2-5% of hawthorn, 2-5% of ligusticum wallichii, 2-5% of angelica sinensis, 1-3% of sun-dried ginseng and 1-3% of liquorice. The invention also discloses a pharmaceutical preparation prepared from the traditional Chinese medicine composition for treating cancerous anorexia. The traditional Chinese medicine composition is guided by basic theories of Yi medicine, comprehensively intervenes and treats cancerous anorexia by ascending lucidity and descending turbidity, strengthening spleen and stomach, benefiting qi and nourishing blood, strengthening body resistance and regulating body and regulating yin and yang balance of human body, is definite in clinical curative effect, free of obvious toxic and side effects and good in patient adaptability, and can be used for cancerous anorexia patients caused by various reasons for a long time.

The application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating infantile anorexia, a topical plaster and a preparation method. The traditional Chinese medicine is prepared by combining clove, amomum villosum, fried atractylodes, fried atractylodes rhizome, costus, zedoary, radish seed and borneol with corresponding auxiliary materials. In the prescription, clove is the monarch, which can warm yang and supplement fire and warm earth; amomum villosum, atractylodes and atractylodes rhizome are the ministers, which can invigorate the spleen and eliminate dampness, assist the monarch in warming the spleen yang and eliminating dampness and ascending clear; costus, radish seed and zedoary are the aids, which can invigorate the spleen and digest food, and can lower the stomach and eliminate stagnation; borneol is slightly bitter and cold, which can open the orifices, awaken the spirit, clear heat and relieve pain, and the dispersing and diffusing function of borneol can lead the other medicines to the heart and abdomen, and disperse the orifices, and borneol is the ministerial medicine. The combination of the medicines can achieve good effects.

Pharmaceutical compositions comprising a neuropeptide B / W receptor (NPBWR1) antagonist / inhibitor are described for use in methods of treating, ameliorating or preventing mood disorders / affective disorders and / or chronic stress and / or anxiety disorders and / or Parkinson's disease. Furthermore, pharmaceutical compositions comprising a neuropeptide B / W receptor (NPBWR1) agonist / activator are described for use in methods of treating, ameliorating or preventing bipolar disorder manic (ICD-10 F31), appetite disorders, preferably anorexia or bulimia. Furthermore, a method of assessing the activity of a candidate molecule suspected to be a NPBWR1 antagonist / inhibitor or agonist / activator is described.

Disclosed herein are methods for diagnosing a subject with loss and / or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and / or ageusia. Also disclosed herein are methods and compositions for treating a subject for loss and / or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and / or ageusia.

Use of sesquiterpenoids having the structures of formula (I) and formula (П) in relieving nausea and vomiting. The sesquiterpenoids having the structures of formula (I) and formula (П) are cedrol and analogs, racemates, stereoisomers, tautomers, isotopically labeled compounds, solvates, polymorphs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof, wherein R 1 to R 8 are as described in the claims and the description. The compounds having the structures of formula (I) and formula (П) can reduce kaolin intake in pica rats, significantly alleviate the symptoms of nausea and vomiting induced by chemotherapeutic drugs such as cisplatin when used in tumor treatment, and can also relieve vomiting caused by gastrointestinal injury, inflammatory diseases, anorexia, etc. In addition, the compounds having the structures of formula (I) and formula (П) can also be used in the preparation of drugs for relieving / treating nausea and vomiting or in the preparation of foods for assisting in protecting the gastric mucosa.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine oral liquid for enlivening spleen and treating anorexia and a preparation method thereof. The traditional Chinese medicine oral liquid comprises raw material medicines, a sweetening agent, an isotonic agent and water, the raw material medicines comprise the following components in parts by weight: 2-3 parts of haws, 2-3 parts of radix puerariae and 1-2 parts of roses; the sweetening agent is honey, xylitol and maltitol. Honey is replaced with the specific sweetening agent, sweet greasy feeling caused by the honey is avoided, meanwhile, oral osmotic pressure balance is adjusted in cooperation with the isotonic agent, the taste is remarkably improved, and the acceptability of a patient is higher; meanwhile, the sweetening agent has a good stabilizing effect on flavonoid active ingredients, degradation of the active ingredients is avoided, and the prepared oral liquid is longer in storage life.

The invention discloses a traditional Chinese medicine composition, ointment and application thereof. The traditional Chinese medicine composition contains radix pseudostellariae, Chinese yam, poria cocos, angelica sinensis, liquorice, lily, lotus seeds, rice-grain sprouts, hawthorn, bighead atractylodes rhizome, galangal, cassia twigs, radix paeoniae alba, paederia scandens, curcuma zedoary and hyacinth bean flowers, and is obtained based on long-time summarization and continuous compatibility adjustment. Ointment prepared from the traditional Chinese medicine composition can effectively treat infantile anorexia, infantile tourette syndrome and dwarf syndrome caused by spleen deficiency, and the traditional Chinese medicine composition can be used for preparing medicines for treating infantile anorexia, dwarf syndrome, infantile tourette syndrome and the like caused by spleen deficiency. In addition, the traditional Chinese medicine composition is prepared into traditional Chinese medicine ointment, has the advantages of being high in medicine content, good in taste, convenient to take, easy to accept and the like, and is beneficial to treatment of diseases caused by spleen deficiency.

The present invention discloses a Qi-Zao oral liquid for treating infantile anorexia, which is prepared by extracting the following raw medicinal materials in parts by weight: 6-10 parts of wolfberry fruit, 8-12 parts of Chinese date, 5-10 parts of Codonopsis pilosula, 6-10 parts of prepared rehmannia root, 8-12 parts of dried tangerine peel, 10-14 parts of Atractylodes macrocephala, 4-8 parts of Scutellaria baicalensis, 6-10 parts of gardenia fruit, 10-14 parts of stir-fried hawthorn fruit, 8-12 parts of medicated leaven, 6-10 parts of dried gallus stomach membrane, 8-12 parts of semen raphani, 6-10 parts of polygonatum odoratum, 5-10 parts of smoked plum, 6-10 parts of Glehnia littoralis, 6-10 parts of Ophiopogon japonicus, 10-14 parts of fingered citron, 6-10 parts of amomum villosum. It can invigorate the spleen and kidney, soothe the liver and strengthen the spleen, eliminate accumulation and clear heat, promote digestion and guide stagnation, nourish the stomach and yin, nourish the lung yin, promote qi movement and invigorate the spleen. They are commonly formulated to treat infantile anorexia of the type of deficiency of the spleen and kidney, achieving very good effects, and the preparation method thereof is also disclosed.