801 results about "Pharmaceutical Aids" patented technology

A solid oral immediate release formulation of LSD, wherein the composition is produced by lyophilization of a feedstock in a pre-formed mold to form an orally disintegrating tablet. A method of making a solid oral immediate release formulation of LSD by lyophilizing a flash frozen stock solution of LSD and excipients, including a non-gelling matrix former, filler, and binder in a pre-formed mold, and forming an orally disintegrating tablet. A method of treating an individual by administering a solid oral immediate release formulation of LSD, wherein the composition is produced by lyophilization of a feedstock in a pre-formed mold to form an orally disintegrating tablet and treating the individual.

The invention relates to the field of biomedical application of inorganic materials, in particular to application of lanthanum carbonate in preparation of drugs for resisting liver cirrhosis and inhibiting liver inflammations, the drugs comprise lanthanum carbonate and pharmaceutically acceptable auxiliary materials, the drugs are ground and then mixed with food to prepare a drug mixture, and the drug mixture is prepared into the drug for resisting liver cirrhosis and inhibiting liver inflammations. The mass ratio of the lanthanum carbonate in the medicine mixture is 1-10%, and the mechanism of the lanthanum carbonate for treating the liver cirrhosis is as follows: interference or blocking of activation and proliferation of hepatic stellate cells, inhibition of extracellular matrix generation and promotion of extracellular matrix degradation. According to the invention, a rat liver cirrhosis model is constructed through chemical induction, and the effects of reversing liver cirrhosis and inhibiting liver inflammation are found when a rat is treated by taking lanthanum carbonate orally, so that a new candidate drug is provided for clinical treatment of liver cirrhosis.

The invention discloses a colchicine external preparation with high intradermal residual quantity and percutaneous transmittance as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The invention provides a colchicine external preparation with high intradermal residue and transdermal transmittance. The colchicine external preparation comprises: a) colchicine or a pharmaceutically acceptable salt thereof; b) a penetration enhancer; c) pharmaceutically acceptable excipients and / or excipients; the penetration enhancer is at least one of polyglycerol oleate or isosorbide dimethyl ether. The drug loading capacity and the percutaneous transmittance of the colchicine external preparation disclosed by the invention are remarkably improved. When polyglycerol oleate is selected as a penetration enhancer to prepare colchicine gel, the intradermal retention volume can reach 358.08 micrograms within 20 hours. When isosorbide monomethyl ether is selected as a penetration enhancer to prepare ethosome gel, the accumulated penetration amount can reach 106.87 mu g / cm < 2 >, and the intradermal residual amount can reach 90.58 mu g or above.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine spray for treating rhinitis and a preparation method thereof.The traditional Chinese medicine spray is prepared from flos magnoliae liliflorae, fructus xanthii, herba ephedrae, fructus forsythiae, flos lonicerae, radix angelicae, herba asari, menthol, herba centipedae and herba menthae. Refining to obtain a fluid extract; and mixing the fluid extract with a penetration enhancer consisting of aminoketone and menthol, a sodium hyaluronate mucous membrane repairing agent, a pH regulator, an isoosmotic adjusting agent and a preservative to prepare spray liquid medicine, and finally performing sterile filtration and filling. Through efficient extraction and synergism of composite auxiliary materials, the permeability and bioavailability of the medicine are remarkably improved, and the symptoms such as nasal obstruction and running nose can be quickly relieved; meanwhile, the anti-inflammatory function and the function of actively repairing the damaged nasal mucosa are achieved, and the recurrence rate is reduced from the source; the pH and osmotic pressure of the preparation are precisely adjusted, the use is comfortable, and the quality is stable and controllable.

The invention relates to the technical field of artificial intelligence and biological medicine crossing, discloses a pharmaceutical preparation AI intelligent optimization method and system, and aims to solve the problems of difficult multi-source data integration, limited feature expression, optimization closed loop deficiency and insufficient model generalization ability in the prior art. The method comprises the following steps: collecting multi-source pharmaceutical data and carrying out normalization processing; constructing a knowledge graph covering a whole chain of medicine, auxiliary materials, process, performance and safety; receiving a design target and a constraint condition input by a user; and outputting a candidate preparation formula by using a graph attention guided sequence generation model. According to the scheme, intelligent generation and dynamic optimization of the preparation formula are achieved, the research and development efficiency and the formula success rate are remarkably improved, the development period is shortened to be within 45 days, the key performance prediction accuracy is improved, the invalid experiment cost is reduced, and deep application of AI in the field of high-end pharmacy is promoted.

The invention discloses traditional Chinese medicine suspension eye drops and a preparation method thereof, and the traditional Chinese medicine suspension eye drops are prepared from the following raw materials in parts by weight: 1-3 parts of a traditional Chinese medicine composition, 4-7 parts of hydroxypropyl-beta-cyclodextrin, 0.5-2 parts of microcrystalline cellulose-sodium carboxymethyl cellulose and auxiliary materials. The traditional Chinese medicine suspension eye drops provided by the invention abandon a traditional eye ointment form, are directly dropped for use, are convenient to use, have good stability and dispersity, and are excellent in use curative effect and medication experience; on the basis of keeping the clinical efficacy of the Marcher eight-treasure ancient prescription, secondary development and research are scientifically carried out, so that the Marcher eight-treasure ancient prescription plays a greater clinical treatment role, and has a wider market development prospect.

A solid oral immediate release formulation of LSD, wherein the composition is produced by lyophilization of a feedstock in a pre-formed mold to form an orally disintegrating tablet. A method of making a solid oral immediate release formulation of LSD by lyophilizing a flash frozen stock solution of LSD and excipients, including a non-gelling matrix former, filler, and binder in a pre-formed mold, and forming an orally disintegrating tablet. A method of treating an individual by administering a solid oral immediate release formulation of LSD, wherein the composition is produced by lyophilization of a feedstock in a pre-formed mold to form an orally disintegrating tablet and treating the individual.

The invention relates to a method for determining the content of sorbitol and glycerol as auxiliary materials in a fudosteine oral solution, which has the advantages of high sensitivity, strong specificity, good accuracy and simple and rapid operation, can reduce the difficulty of preparation development, reduce the workload of prescription development, shorten the research and development time and further improve the BE passing rate, and has practical significance.

The invention belongs to the field of pharmaceutical preparations. The invention relates to a novel dosage form of an isavuconazole sulfate freeze-dried tablet, and a prescription and a process for preparing the isavuconazole sulfate freeze-dried tablet by adopting a freeze-drying method. The isavuconazole sulfate freeze-dried tablet is prepared from isavuconazole sulfate serving as a main drug and pharmaceutic adjuvants. Water is not needed during taking, and the tablet can be rapidly disintegrated after being put in the mouth and is suitable for patients with dysphagia such as old people and children; the production process of the isavuconazole sulfate freeze-dried orally disintegrating tablet is simple in technology, easy to control and suitable for industrial production.

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

This invention belongs to the field of pharmaceutical formulation technology and provides a vinpocetine suspension and its preparation method. The vinpocetine suspension of this invention comprises the following raw materials in specific mass parts: vinpocetine, a suspending agent, a solubilizer, a stabilizer, and water. The vinpocetine suspension of this invention is suitable for oral administration. The excipients in the suspension include a suspending agent, a solubilizer, and a stabilizer. The solubilizer inhibits the aggregation of vinpocetine nanoparticles and improves the solubility and dispersion uniformity of vinpocetine nanoparticles in water. The suspending agent and stabilizer together construct a spatially stable structure, ensuring the suspension and dispersion of vinpocetine nanoparticles and resisting sedimentation. The suspending agent, solubilizer, and stabilizer work synergistically to achieve nanoscale distribution and uniform dispersion and suspension of vinpocetine, significantly improving the bioavailability of vinpocetine. High-pressure homogenization achieves nanoscale distribution of vinpocetine, with a particle size of 200-300 nm.

This invention discloses an energy-saving control system for drying equipment based on multidimensional factor analysis, belonging to the field of intelligent control technology. The system includes: interactively obtaining the pre-drying material characteristics of the pharmaceutical excipients to be dried; pre-constructing a material drying optimization space; locating initial drying control parameters; obtaining multiple sets of equipment parameter adjustment values ​​mapped to multiple drying stages; performing drying simulations on the pharmaceutical excipients to be dried using stage moisture content as a constraint, obtaining multiple sets of drying times, multiple sets of equipment energy consumption, and multiple sets of excipient loss rates; obtaining a target drying control array; and running the drying equipment to perform low-energy drying of the pharmaceutical excipients to be dried. This invention solves the technical problems of existing energy-saving control systems for drying equipment, which rely on fixed parameters and are difficult to accurately match the changes in the characteristics of different pharmaceutical excipients, leading to increased energy consumption and insufficient drying quality and efficiency of pharmaceutical excipients. It achieves the technical effects of effectively reducing energy consumption, improving drying efficiency, and enhancing product quality stability.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses timolol maleate eye drops and a preparation method thereof. The timolol maleate eye drops provided by the invention are prepared from timolol maleate, glycine, trehalose, disodium hydrogen phosphate and sodium dihydrogen phosphate. According to the timolol maleate eye drops, the components of the timolol maleate eye drops are reasonably designed, and glycine and trehalose are added into the timolol maleate eye drops, so that degradation of active components of the timolol maleate eye drops is also reduced while the types and the dosage of auxiliary materials are reduced, and the eye drops have the advantages that the eye drops are safe and reliable; the stability of the timolol maleate eye drops placed for a long time is obviously improved, and the medication safety of the timolol maleate eye drops is ensured.

The application discloses a sensitized ferroptosis lipid nano regulator and a preparation method and application thereof, and belongs to the technical field of new adjuvants and new dosage forms of drug preparation combined treatment. The lipid nano regulator is co-assembled by a GPX4 inhibitor and a FASN inhibitor through intermolecular forces, and is modified with an oxidation-reduction sensitive PEG modifier, a molar ratio of the GPX4 inhibitor and the FASN inhibitor is 10:1-1:10, a mass ratio of the sum of the GPX4 inhibitor and the FASN inhibitor to the PEG modifier is 10:90-90:10, and the intermolecular forces include pi-pi stacking force, hydrophobic force and hydrogen bond. The co-assembled nano preparation provides a new strategy and more choices for the development of drug delivery, and meets the urgent needs of high-efficiency and diverse ferroptosis treatment strategies in preparations in the clinic.

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from an angiotensin II receptor blocker, folic acid, 5-methyltetrahydrofolic acid and acceptable auxiliary materials. The composition has the advantages that the composition has the functions of reducing blood pressure and preventing and treating osteoporosis, and is particularly suitable for hypertension and osteoporosis susceptible people with MTHFR C677T gene mutation. Through the implementation of the invention, the pharmaceutical composition is provided for people with a specific genetic background, so that precise medical treatment is realized, the curative effect is improved, the side effect is reduced, and the medication compliance is improved.

Disclosed are an mRNA pharmaceutical composition for preventing and treating tuberculosis and use thereof. The mRNA pharmaceutical composition comprises: an mRNA molecule encoding a Mycobacterium tuberculosis antigen, and a pharmaceutically acceptable excipient. The Mycobacterium tuberculosis antigen comprises the following antigen components: at least one early-secreted antigen of Mycobacterium tuberculosis or an immunologically active fragment thereof; PE / PPE family antigen WAG22 of Mycobacterium tuberculosis or an immunologically active fragment thereof; and at least one latent-related antigen of Mycobacterium tuberculosis or an immunologically active fragment thereof. The mRNA pharmaceutical composition does not comprise or further comprises an mRNA molecule encoding a cytokine. The pharmaceutical composition is used for preparing a tuberculosis vaccine, which may serve as a prophylactic vaccine for preventing latent activation or as a therapeutic drug for treating active tuberculosis, exhibiting a significant inhibitory effect on Mycobacterium tuberculosis.

The invention relates to a traditional Chinese medicine pillow with orifice opening and nerve soothing functions and a preparation method thereof, in particular to a medicine pillow with chrysanthemum and wild chrysanthemum as main active ingredients. The medicine pillow is prepared from 300-600 parts of chrysanthemum, 20-70 parts of honeysuckle, 10-30 parts of asarum and optional auxiliary materials such as mint and centipeda minima according to a specific proportion through the steps of cleaning, smashing into particles of 13 mm, scientific compatibility and packaging. Through the synergistic effect of the chrysanthemum and the wild chrysanthemum flower and in cooperation with volatile components of other medicinal materials, the rhinitis, headache, insomnia and other diseases can be effectively relieved, and meanwhile the effects of refreshing air and adjusting sleep are achieved. The outer cover of the medicine pillow is made of breathable cotton cloth and filled with standardized medicine bags, the medicine is replaced every two months, and the continuous curative effect is ensured.

This invention discloses a highly active compound health supplement made from Cordyceps sinensis, Artemisia argyi, and rhubarb, and its preparation method, belonging to the field of health food and pharmaceutical preparation processing technology. The method includes: adding artificial Cordyceps sinensis ultrafine powder, prepared Rhubarb tanguticum fine powder, Artemisia argyi leaf extract, microcrystalline cellulose PH102, and maltodextrin into a mixer and premixing at 25-35 rpm to allow the powder to adhere to the surface of the excipients; after tableting, the tablets are subjected to ultra-high pressure treatment at 350-380 MPa. This invention achieves uniform distribution and performance optimization of the formulation components without damaging the activity of heat-sensitive components through precise coupling of premixing strength and ultra-high pressure modification parameters. Experiments show that the obtained formulation has an adenosine retention rate ≥96%, a dissolution rate ≥85% after 5 minutes, and excellent moisture resistance and mechanical strength, solving the technical problems of large activity loss, easy moisture absorption, and slow dissolution in traditional formulations.

The invention discloses a mixed auxiliary material for traditional Chinese medicine film coated tablets and a preparation method of the mixed auxiliary material. The mixed auxiliary material comprises the following components in percentage by weight: 50-60% of etherified crosslinked starch, 15-20% of pregelatinized starch, 10-15% of sodium carboxymethyl starch, 0.6-0.8% of magnesium stearate and 2-3% of talc. The etherified cross-linked starch is used for replacing a traditional polymer, a cross-linked structure of the etherified cross-linked starch blocks water molecule permeation, pre-gelatinized starch improves powder fluidity, crushed talcum powder is mixed with the pre-gelatinized starch, microgaps are filled, a friction system is reduced, and the situation that the sheet surface is rough and prone to sticking is avoided; the dynamic balance of sodium carboxymethyl starch and magnesium stearate ensures the synergism of disintegration and lubrication, and completely avoids the problems of poor tablet hardness, slow disintegration and large weight difference of traditional Chinese medicine film-coated tablets.

The invention discloses a vitamin D3-polyethylene glycol composition and a preparation method thereof, the vitamin D3-polyethylene glycol composition comprises vitamin D3, a dispersion medium, an adsorbent and polyethylene glycol, the vitamin D3 is dissolved in the dispersion medium, the adsorbent is used for adsorption, and then the mixture is added into hot-melt polyethylene glycol for dispersion to obtain the vitamin D3-polyethylene glycol composition. The dosage of the polyethylene glycol is controlled to be 70%-90% of that of the vitamin D3-polyethylene glycol composition; the vitamin D3 in the calcium carbonate / vitamin D3 pharmaceutical composition prepared by the invention has excellent long-term stability, and also has good mixing uniformity and content uniformity; the preparation process is simple, the vitamin D3 and other auxiliary materials do not need to be prepared into large particles in advance, the particles are easy to transfer without freeze-drying, the material loss is less, and the preparation method is suitable for industrialization.

This description describes a method for treating pain by administering a pharmaceutical composition containing a therapeutically effective amount of margaric acid to a subject requiring pain treatment. Pharmaceutical compositions, such as topical and transdermal compositions, containing margaric acid and a pharmaceutically acceptable excipient are also described. A pain-relieving composition containing margaric acid, eicosapentaenoic acid, and a pharmaceutically acceptable excipient is further described.

The invention discloses a bone strengthening and pain relieving preparation and a preparation and use method thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is prepared from unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, radix angelicae, radix cynanchi paniculati, ardisia crenata, radix salviae miltiorrhizae, cortex phellodendri, radix clematidis, peach kernels, flos carthami, cortex acanthopanacis, rhizoma drynariae, ground beetles, herba asari, short-pedicel aconite roots, borax and borneol. The auxiliary materials comprise sesame oil and minium. The prescription has the treatment rules and treatment methods of setting bones, relieving pain, clearing damp, dredging collaterals, diminishing swelling and dissipating blood stasis. The traditional Chinese medicine is mainly used for treating traumatic injury, soft tissue contusion and arthralgia, and belongs to qi stagnation and blood stasis type. The preparation is used by spreading the preparation on a non-woven fabric or oil paper. The plaster is heated and softened, and is pasted on an affected part. The traditional Chinese medicine has the symptoms of onset caused by trauma or strain, local swelling, stabbing pain, numbness of limbs, joint movement disadvantage or aggravated arthralgia when encountering wind-cold. The tongue is light, the tongue coating is thin white or white greasy, and the pulse is tight or soft.

The invention discloses a modified glutinous rice flour auxiliary material for controllable release medicine tablets and a preparation process of the modified glutinous rice flour auxiliary material, and relates to the technical field of biological medicines.The multifunctional auxiliary material with a specific microstructure and corrosion dynamic characteristics is obtained by taking glutinous rice flour with the amylopectin content larger than or equal to 80% as a raw material and conducting a three-stage process of pretreatment, directional modification and aftertreatment; the tablet has the functions of filling, bonding, disintegrating or skeleton controlled release, and can accurately regulate and control the drug release according to the dosage form demand. The invention aims to solve the problems that the traditional auxiliary material has a single function and is difficult to adapt to the release requirements of multiple types of drugs, realizes the multifunctional integration of the natural auxiliary material and the controllability of the release behavior, and remarkably improves the suitability of the preparation and the process stability.

The invention relates to the technical field of analytical chemistry detection, in particular to a method for determining trace nitrite in pharmaceutic adjuvants.The method comprises the steps that an acetonitrile solution, a potassium hydroxide solution, a phosphate buffer solution, a sulfuric acid solution, a 2, 3-diaminonaphthalene solution and a reference substance working solution are provided; the method comprises the following steps: preparing a standard curve solution and a test sample solution, and carrying out ultra-high performance liquid chromatography-tandem mass spectrometry analysis detection: respectively carrying out sample injection detection on the test sample solution and the prepared standard curve solutions with different concentrations under preset chromatographic conditions and mass spectrometry conditions, recording detection results of the standard curve solutions with different concentrations to make a standard curve, and calculating the content of nitrite in the test solution by adopting a standard addition method according to the standard curve and the detection result of the test solution. The method disclosed by the invention can be used for rapidly determining trace nitrite in a drug sample, and can be used for determining the trace nitrite in pharmaceutical adjuvants and detecting the nitrite in drugs.

The invention discloses a lumepirone long-acting microsphere sustained-release preparation without a release stagnation period in an early stage, which comprises a lumepirone active ingredient and a medicinal polymer auxiliary material in a mass ratio of (1: 4)-(1: 1), the medicinal polymer auxiliary material is at least one of glycolide-lactide copolymers with the weight-average molecular weight of 5000-150000 Da, and the molar ratio of lactic acid units to glycolic acid units of the glycolide-lactide copolymers is (50: 50)-(95: 5). The lumepirone long-acting microsphere sustained-release preparation without a release arrest phase in the early stage is obtained by specially limiting drying conditions in liquid and medicinal polymer auxiliary materials, the release of the lumepirone long-acting microsphere sustained-release preparation can be maintained for 2 weeks to 1 month without oral administration of the long-acting sustained-release microspheres of lumepirone capsules, the safety and effectiveness of the medicine are met, and the sustained-release preparation is suitable for clinical application. Meanwhile, the problems of early-stage long-time stagnant release and early-stage burst release of the long-acting microsphere preparation can be solved, the compliance can be effectively improved, convenience is provided for patients to the maximum extent, and the economic cost is reduced.

This invention relates to an isosorbide dinitrate pharmaceutical composition injection and its preparation method. In addition to isosorbide dinitrate, the injection formulation also contains meglumine and glutathione. The preferred specifications are 5ml:5mg and 10ml:10mg. The isosorbide dinitrate injection prepared according to the formulation and process of this invention has the characteristics of high excipient safety, simple process, extremely high quality stability and good safety, which is significantly better than the prior art.

The invention relates to the technical field of health-care external application agents, in particular to Qianzhou treatment Shukangtang tendon-relaxing and bone-penetrating health-care paste which is formed by combining subpackaged powder and subpackaged liquid. The powder comprises a mixture of the following Chinese herbal medicines according to a mass ratio: safflower, homalomena occulta, radix angelicae pubescentis, verbena, dragon's blood and centipede, and each component can be adjusted in a range of + / -20% as required; the liquid is based on a soaking decoction obtained by soaking and decocting safflower, radix angelicae, caulis spatholobi and mint as main medicinal materials in water, filtering and cooling, the content of ethanol in the liquid is 2-12%, the content of glycerol in the liquid is 1-6%, and the dosage of borneol is 0.1-2.0 g; the powder is a Chinese herbal medicine powder mixture which is dried, crushed and sieved. According to the invention, powder and liquid are subpackaged, and detectable indexes such as granularity, moisture and auxiliary material ratio and the like are determined, so that the standardization and repeatability of the formula and the process are realized, the stability and the transdermal permeation efficiency of the product are obviously improved, and the curative effect similar to that of a store can be obtained after on-site / family rapid blending.

The present disclosure is directed to pharmaceutical compositions comprising a PDE V inhibitor and one or more pharmaceutical excipients or additives wherein the pharmaceutical compositions are in the form of liquid pharmaceutical compositions. The pharmaceutical compositions of the present disclosure are useful for the treatment of diseases or conditions which are treatable by administration of PDE V inhibitor drug such as pulmonary arterial hypertension, erectile dysfunction, etc.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a preparation method of a traditional Chinese medicine external preparation for arthralgia based on blood circulation promoting and blood stasis removing, which comprises the following steps: extracting ferulic acid from angelica sinensis and ligusticum wallichii by adopting a supercritical CO2 fluid extraction process; extracting safflower, frankincense and other medicinal materials to obtain a synergistic active ingredient extract; the ferulic acid is used as a first hydrogen bond donor to react with lauric acid used as a temperature-sensitive phase change hydrogen bond donor and choline chloride used as a hydrogen bond acceptor, and the temperature-sensitive bioactive ternary eutectic solvent is prepared; loading the synergistic active ingredient extract in the solvent at low temperature to form a medicine mother solution; and finally, mixing the medicine mother liquor with auxiliary materials to prepare the external preparation. Ferulic acid in medicinal materials serves as a structural unit of a functional solvent, the solvent prepared under the mild condition has biological activity and temperature-sensitive phase change characteristics, a medicine storage cavern can be formed on the skin surface in situ, long-acting slow release and efficient transdermal absorption of active ingredients are achieved, and the curative effect and safety of a preparation are improved.