119 results about "Softgel" patented technology

The invention provides a starch-based soft capsule composition, a starch-based soft capsule and a preparation method of the starch-based soft capsule, and belongs to the technical field of medicines. The starch-based soft capsule composition is characterized by being prepared from the following components in parts by weight: 50 to 100 parts of plant starch, 20 to 100 parts of modified starch, 0.1 to 5 parts of thickening agent and 0.1 to 5 parts of plasticizer, the plant starch comprises pea starch and corn starch in a mass ratio of (10-60): (40-50); the modified starch comprises modified corn starch and modified potato starch in a mass ratio of (1-5): (1-8). The starch-based soft capsule disclosed by the invention is high in joint closing rate; the starch-based soft capsule is high in transparency, not easy to age and good in stability after being stored for a long time.

The invention provides an ethyl eicosapentaenoate soft capsule as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The ethyl eicosapentaenoate soft capsule comprises a content and a capsule shell, the content is prepared from the following components in parts by mass: 10 to 30 parts of ethyl eicosapentaenoate, 40 to 70 parts of oil phase matrix, 5 to 15 parts of emulsifier, 2 to 8 parts of antioxidant composition and 0 to 5 parts of cosolvent; the capsule shell comprises the following components in parts by mass: 40-60 parts of gelatin, 25-40 parts of a plasticizer, 20-35 parts of water, 0.5-3 parts of an opacifying agent and 0.1-1 part of an antioxidant. The invention provides the ethyl eicosapentaenoate soft capsule with excellent stability and safety and the preparation method thereof, and the technical problem that EPA-E is easy to oxidize is successfully solved by matching with an optimized anti-oxidation system and process parameters.

The invention belongs to the technical field of oral medicine preparations, and particularly relates to a microcrystal suspension multi-ball soft capsule and a preparation method and application thereof.The microcrystal suspension multi-ball soft capsule is of a three-level structure formed by a shell, temperature-sensitive hydrogel and medicine-carrying microcrystal balls, and the medicine-carrying microcrystal balls are in a three-level structure under the spatial constraint effect of the temperature-sensitive hydrogel. The medicine-carrying microcrystalline balls are prevented from settling or freely moving; after the medicine is orally taken and enters a body, the shell is rapidly disintegrated, the temperature-sensitive hydrogel is slowly corroded, the medicine-carrying microcrystalline balls are released accordingly, and it is ensured that the medicine nanocrystals are stably dissolved out. Besides, in the preparation process, only conventional equipment, such as a high-pressure homogenizer and a soft capsule pressing machine, is needed, and a special nano synthesis or crosslinking process is not needed; the preparation process is easy to control and meets the large-scale production requirement.

The application belongs to the technical field of soft capsules, and discloses a starch-based soft capsule material and a preparation method thereof. The preparation method comprises the following steps: mixing wheat starch and deionized water, adding a sodium periodate solution to react, so as to obtain dialdehyde starch; reacting the dialdehyde starch with glycidyl methacrylate and triethylamine, so as to obtain grafted modified starch; mixing the grafted modified starch with modified nano-silicon dioxide, and reacting after ultrasonic oscillation, so as to obtain nano-silicon dioxide composite modified starch; mixing the composite modified starch with polyvinyl alcohol and polyvinylpyrrolidone, so as to obtain a film forming solution; and after the film forming solution is cast and dried, hot pressing is performed, so that the starch-based soft capsule material is finally obtained. The starch is subjected to multiple hydrophobic modifications, so that the hydrophilic performance is reduced, and the stability of the soft capsule is improved.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

This invention provides a starch-based soft capsule composition, a starch-based soft capsule, and a method for preparing the same, belonging to the field of pharmaceutical technology. The starch-based soft capsule composition is characterized by comprising, by weight, 50-100 parts plant starch, 20-100 parts modified starch, 0.1-5 parts thickener, and 0.1-5 parts plasticizer; the plant starch is pea starch and corn starch in a mass ratio of (10-60):(40-50); the modified starch is modified corn starch and modified potato starch in a mass ratio of (1-5):(1-8). The starch-based soft capsules of this invention have a high seam sealing rate; they exhibit high transparency after long-term storage, are not prone to aging, and have good stability.

The invention relates to the technical field of biological medicine preparations, and discloses a calcium, vitamin D and vitamin K. A content composition of the soft capsule comprises a microgel skeleton composed of amphiphilic polypeptide calcium ions and vitamin oil drops, the hydrophobic end of amphiphilic polypeptide adsorbs the oil drops, and the hydrophobic end of the amphiphilic polypeptide adsorbs the vitamin oil drops. A hydrophilic end of the composition is bridged by calcium ions to form a network, the composition also comprises a histidine-enriched polypeptide which can form a protective shielding layer on the surface of a skeleton under acidic pH, the calcium ions are converted from a chemical destroyer to a structural stabilizer, and a static synergistic system is constructed, so that the contact degradation of calcium and vitamins is eliminated, and the stability of the composition is improved. The performance contradiction between the high calcium content and the vitamin stability is avoided, and the endophytic environmental adaptability of the composition is improved.

The invention relates to a soft capsule, in particular to a long-acting DHA soft capsule and a preparation method thereof. The long-acting DHA soft capsule is prepared from the following raw materials in parts by weight: 10 to 11 parts of xanthan gum, 3 to 4 parts of locust bean gum, 0.5 to 1 part of sericin, 0.5 part of glycerol and 13.5 to 16 parts of deionized water. The preparation method comprises the following steps: stirring and heating to 75-80 DEG C until all the raw materials are dissolved in water or melted and solid particles visible to naked eyes do not exist, so that the raw materials are glue liquid; spreading the glue solution into a rubber sheet; pressing the capsule skin and the DHA grease composition into capsules through a soft capsule pelleting machine; after shaping, polishing and drying to obtain the long-acting DHA soft capsule. The capsule skin of the long-acting DHA soft capsule is of a single-layer structure, the structure is simple, the physicochemical property is determined, a traditional soft capsule pelleting machine can be used for pressing, an additional secondary coating process is not needed, and the production process is simplified; through cooperation of xanthan gum and locust bean gum, the gum skin keeps certain dimensional stability in a freezing environment.

The present application belongs to the field of pharmaceutical analysis, and particularly relates to a dissolution determination method for soft capsule preparation, which installs a screen on the upper side of the stirring paddle of a dissolution device, so that when the soft capsule shell has a large crack and large oil drops appear, the large oil drops can be dispersed into small droplets through the screen, thereby ensuring that the drug dispersion measurement result in the dissolution cup is scientific and reasonable.

The invention belongs to the field of propolis soft capsules, and provides a propolis soft capsule and a preparation method thereof.The propolis soft capsule is prepared from, by weight, 30%-50% of propolis extract, 40%-60% of modified egg yolk phospholipid and 5%-15% of cosolvent; wherein the modified egg yolk phospholipid is partially hydrogenated, the sn-2 site of the modified egg yolk phospholipid is substituted by branched chain fatty acid, and the iodine value of the modified egg yolk phospholipid is shown in the specification; according to the invention, specifically modified egg yolk phospholipid is used as a core carrier, and the unique molecular structure of the egg yolk phospholipid can be efficiently self-assembled in an oil phase, so that the egg yolk phospholipid has excellent wrapping and solubilizing capabilities on various active components in propolis. The propolis extract can be stably loaded into an oil phase to form a transparent nano-dispersion with small average particle size and low polydispersity index, so that high-efficiency and high-loading oil dissolution of propolis is realized, and a stable nano-dispersion system is formed.

The invention discloses a rosa roxburghii tratt fruit and ganoderma lucidum soft capsule for enhancing immunity and a preparation method thereof, and relates to the technical field of health-care food, the rosa roxburghii tratt fruit and ganoderma lucidum soft capsule comprises a content and a capsule shell wrapping the content; the content is prepared from the following components in parts by weight: 55 to 65 parts of roxburgh rose juice concentrated powder, 55 to 65 parts of lucid ganoderma extract, 350 to 380 parts of camellia oleosa seed oil and 12 to 18 parts of beewax; the capsule shell is prepared from the following components in parts by weight: 115 to 125 parts of gelatin, 115 to 125 parts of purified water, 2.5 to 3.5 parts of caramel color, 0.2 to 0.4 part of titanium dioxide and 0.015 to 0.025 part of brown iron oxide; the purpose of preparing the immunoregulation roxburgh rose and lucid ganoderma soft capsule which is definite in effect, high in stability, convenient and fast to take and suitable for industrial production is achieved through precise proportioning of the roxburgh rose juice concentrated powder and the lucid ganoderma extract, optimization of an auxiliary material system and precise processes of colloid mill grinding, temperature difference pelleting, gradient drying and the like.

The present application relates to the technical field of medicine, in particular to a kind of preparation and application of self-microemulsifying composition containing lamotrigine.The self-microemulsifying composition includes lamotrigine and self-microemulsifying drug delivery system (SMEDDS) carrier;The SMEDDS carrier includes: by lamotrigine, oil phase, emulsifier and co-emulsifier;The self-microemulsifying composition, by mass ratio, lamotrigine is 0.1% to 18.7%, oil phase is 20% to 33%, milk phase is 67% to 80%, the milk phase is by emulsifier and co-emulsifier, and the mass ratio of emulsifier and co-emulsifier is 25.7 to 32.9%:67.1% to 74.3%, and the mass concentration of lamotrigine reaches 18.7%.The particle size of microemulsion formed by the self-microemulsifying composition dispersed in aqueous medium is less than 50nm or even smaller.The self-microemulsifying composition is prepared into soft capsule, hard capsule, tablet, granule, temperature-sensitive gel and other dosage forms, and is applied in the preparation of antiepileptic drugs.

The invention relates to the technical field of pharmaceutical preparations, in particular to an EPA phospholipid soft capsule composition and a preparation method thereof.The composition comprises EPA phospholipid and an enteric soft capsule shell, the EPA phospholipid is prepared from EPA ethyl ester and a reaction substrate under the action of immobilized phospholipase, and the enteric soft capsule shell comprises an enteric material, a plasticizer and purified water. According to the EPA phospholipid enteric-coated soft capsule provided by the invention, EPA ethyl ester is phosphatidylated, and EPA phospholipid is prepared into the enteric-coated soft capsule, so that stable retention of a medicine in the stomach can be reduced, accurate dissolution of the medicine in the small intestine is realized, the problems of peculiar smell and degradation caused by release of EPA ethyl ester in the stomach are effectively avoided, and the EPA phospholipid enteric-coated soft capsule has the characteristic of pH-enzyme dual response.

The invention discloses a preparation method and application of a soft capsule containing (R)-3-hydroxybutyric acid. The preparation method comprises the following steps: S1, mixing an (R)-3-hydroxybutyric acid solution with a porous material, drying and sieving to obtain composite solid powder; wherein the porous material is selected from any one of gel silicon dioxide, porous starch and isomaltitol; s2, adding a thickening agent into an oily solvent, dissolving, then sequentially adding an antioxidant and the composite solid powder, and uniformly mixing to obtain a soft capsule content; and S3, under a heating condition, mixing glycerol, water, gelatin and an opacifying agent, dissolving and defoaming to obtain a capsule skin glue solution, pelleting the capsule skin glue solution and the soft capsule content through a pelleting machine, and drying to obtain the soft capsule. The soft capsule prepared by the method disclosed by the invention can effectively avoid the corrosion effect of (R)-3-hydroxybutyric acid on the capsule shell, is beneficial to improving the stability, and is simple in preparation process and suitable for industrial production.

The invention discloses a high-content propolis ethanol extract soft capsule and a production process thereof. The contents comprise the following raw materials in parts by weight: 30-40 parts of a high-content propolis ethanol extract, 10-20 parts of nanoscale propolis particles, 55-65 parts of polyethylene glycol 600, 5-8 parts of optimized vegetable oil, 3-8 parts of glycerol, 1-3 parts of a suspending aid, 0.5-1.5 parts of vitamin E, 1-3 parts of nano silicon dioxide and 0.1-0.3 part of sodium citrate; and a capsule shell: 10-15 parts of gelatin, 2-5 parts of glycerol, 12-18 parts of purified water, 0.05-0.15 part of potassium sorbate and 0.1-0.3 part of titanium dioxide. The invention relates to the technical field of propolis products. According to the high-content propolis ethanol extract soft capsule and the production process, a pretreatment process of low-temperature freeze-drying, liquid nitrogen embrittlement and ultramicro wall breaking is adopted, so that propolis cell walls are thoroughly broken, and the specific surface area is greatly increased; in cooperation with a gradient ethanol extraction technology, high-polarity flavonoid and phenolic acid components are extracted by using high-concentration ethanol, and then moderate-polarity active components are extracted by using moderate-concentration ethanol, so that sufficient dissolution of the different-polarity active components is realized.

Disclosed herein are embodiments of a soft gel dosage form that includes a soft gel capsule and a fill composition within the soft gel capsule. The filling composition may include a matrix material and a solvent. The filling composition can flow at a temperature of at least about 40 DEG C and is solid or semi-solid under ambient conditions. Also disclosed are methods of making and using the same, as well as filling compositions for use in such soft gel dosage forms and methods.

The invention relates to the field of soft capsule preparation materials, and discloses a double-layer soft glue film, a preparation method and application thereof and a large-capacity capsule. The double-layer soft glue film comprises a gelatin-based glue layer and an inner barrier layer, the gelatin-based glue layer comprises gelatin, a composite plasticizing system, a shading system and soluble calcium salt; and the inner barrier layer comprises hydroxypropyl methyl cellulose. According to the invention, the compactness and adhesive force of a film body are obviously improved, the peel strength can reach 0.85 N / cm, the oil penetration rate is lower than 1%, and the retention rate of fat-soluble contents reaches 96% or above. The adhesive film is suitable for preparing large-loading high-content fat-soluble soft capsules, and has the advantages of high strength, low migration and excellent damp-heat stability.

This invention discloses a single-herb bezoar preparation based on an ancient prescription; an enteric-coated bezoar soft capsule and its preparation method. The enteric-coated bezoar soft capsule consists of a bezoar dispersion and an enteric-coated soft capsule shell. A sand mill is used to prepare bezoar powder into micron-sized particles with a particle size ≤100μm. The micron-sized bezoar powder is fully dispersed in a dispersion medium, thereby improving the solubility of bezoar. The single-herb bezoar preparation can improve the problem of inconsistent bezoar content in compound bezoar preparations. The process of preparing the ≤100μm micron-sized bezoar dispersion uses non-metallic grinding equipment, avoiding the catalytic reaction of metal ions during the preparation of micron-sized powder. Low-temperature grinding is also used to avoid denaturation of the heat-sensitive active substances in bezoar, better preserving its biological activity. The enteric-coated formulation prevents the drug from being released in the stomach until it reaches the small intestine, avoiding the precipitation of bilirubin and other bile acids in the acidic environment of the stomach, which would otherwise lead to insoluble solids and poor solubility.

Disclosed are a self-emulsifying composition of a coenzyme Q10 with high bioavailability, and a method and device for preparing the same. The composition includes the following components in percentage by weight: 5-35% of a coenzyme Q10, 1-50% of an oil phase, 10-60% of a surfactant, 1-10% of a cosurfactant, 0-7% of an antioxidant, and 0.5-2% of pyrroloquinoline quinone disodium salt. The coenzyme Q10 medicinal liquid obtained can be kept in a clear and transparent solution state at room temperature, can be stably dispersed in water and self-emulsified to a transparent emulsion, significantly improves the bioavailability of the coenzyme Q10 by more than 4 times, and can be filled in capsules or softgels to swallow. The method disclosed by the disclosure includes two steps: material grinding and vacuum self-emulsifying. The method is concise in step and easy to control. Moreover, the device is simple in structure and low in cost.

The invention belongs to the technical field of medicine analysis, and particularly relates to a vitamin E soft capsule dissolution rate determination method and application, a settling basket adding paddle method is adopted, solutions with the pH values of 1.2, 4.5 and 6.8 and containing triton X-100 with the volume percentage being 10% serve as dissolution media, after sampling is conducted for 15 min, 30 min, 45 min, 60 min and 120 min, the dissolution amount at each time point is determined through high performance liquid chromatography, the accumulated dissolution amount is calculated, and the dissolution rate of the vitamin E soft capsule is determined according to the dissolution rate of the vitamin E soft capsule. And drawing a dissolution curve by taking the sampling time as an abscissa and the accumulated dissolution amount as an ordinate. The dissolution rate method provided by the invention can be used for quality control of vitamin E soft capsules and consistency evaluation of production site change, and provides reference for development of dissolution methods of similar grease soft capsules.

The application belongs to the technical field of pharmaceutical preparations, and discloses a soft capsule preparation containing alfacalcidol and a preparation method thereof. The soft capsule preparation comprises a soft capsule shell and content filled in the soft capsule shell, and the content is composed of a drug-containing oil phase and alfacalcidol sustained-release pellets dispersed in the oil phase. The drug-containing oil phase comprises immediate-release alfacalcidol dissolved in an oily base. The sustained-release pellets comprise a blank pellet core, a drug-loaded layer and a separation layer, and the separation layer comprises a combined coating material of Eudragit RS30D and Eudragit RL30D. After oral administration, the alfacalcidol in the oil phase is rapidly released to achieve immediate effect, and the alfacalcidol in the sustained-release pellets is slowly released to maintain the steady state of blood drug concentration. The soft capsule preparation of the application realizes the dual-phase drug release behavior of immediate release and sustained release in the same soft capsule, so that the blood drug concentration is smooth and controllable within 24 hours, the steady state of blood drug concentration is maintained, the frequency of drug administration is reduced, and the risk of side effects such as hypercalcemia is reduced.

Disclosed in certain embodiments is a delayed release softgel capsules comprise a fill material that is encapsulated in a pH dependent shell composition, the pH dependent shell composition including pectin and gellan gum. Also disclosed are methods of preparing any of the delayed release softgel capsules described herein and methods of use thereof.

The invention relates to the technical field of probiotics, in particular to a gastric acid resistant composite prebiotic and probiotic co-loaded soft capsule as well as a preparation method and application thereof. The gastric acid-resistant composite prebiotic and probiotic co-loaded soft capsule comprises a capsule shell material and a content emulsion, the content emulsion comprises an oil phase and a water phase, the oil phase comprises sunflower seed oil, beewax, lecithin and vitamin E, and the water phase comprises a water phase. The water phase comprises a plurality of composite probiotics such as bifidobacterium bifidum and casein rhamnosus and a plurality of composite prebiotics such as galactooligosaccharide and beta-glucan, and the capsule shell material is a gelatin-chitosan glue solution. According to the co-loaded soft capsule, the compound prebiotics and the probiotics are compounded, so that the anti-oxidation and intestinal regulation synergistic effect is achieved, and the vascular function and the metabolic homeostasis are jointly improved; the gelatin-chitosan composite capsule is prepared by combining a low-temperature film forming technology, a compact and stable gelatin-chitosan composite capsule shell is formed, and the stability and gastric acid tolerance of active ingredients are greatly improved, so that the comprehensive protection effect of delaying senile cardiovascular aging is favorably realized.

The invention discloses an enteric-coated Shuanghuanglian soft capsule and a preparation method thereof. The enteric-coated Shuanghuanglian soft capsule comprises traditional Chinese medicine fructus forsythiae, honeysuckle, a scutellaria baicalensis extract and an enteric-coated soft capsule shell material, the preparation method comprises the following steps: performing enzyme deactivation by boiling water, performing wet crushing, performing solid-liquid separation, concentrating filtrate, performing alcohol precipitation, and performing vacuum drying to extract the components of fructus forsythiae, honeysuckle and scutellaria baicalensis. The enteric-coated Shuanghuanglian soft capsule dosage form belongs to a completely sealed capsule shell, so that the loss of volatile components is avoided. The enteric-coated soft capsule is insoluble in a gastric solution, and can be dissolved and released when reaching an intestinal environment, so that the damage of gastric acid to medicinal components is avoided, and the characteristic that medicinal components of honeysuckle and fructus forsythiae are absorbed in a small intestine section in literature records is met. Wet grinding extraction is adopted to replace decoction extraction, heat-sensitive active ingredients in the prescription are prevented from being damaged by heat, volatile oil is synchronously collected in the concentration process, the defect that volatile oil contained in fructus forsythiae and honeysuckle in the prior art cannot be collected is overcome, and the effective components of the prescription are prepared in the medicament more completely. In the preparation process, hydrochloric acid is not added for adjusting the pH during scutellaria baicalensis extraction, so that side effects caused by introduction of Cl <-> into the medicament are avoided, and the medicament safety is improved.

The invention discloses an intestinal micro-emulsified targeted release type xanthoceras sorbifolia bunge oil soft capsule and a preparation method thereof, and belongs to the technical field of functional food and health-care product preparations. The soft capsule is composed of a content containing low-temperature squeezed xanthoceras sorbifolia bunge oil and a self-microemulsion delivery system, and a gastrointestinal fluid response type capsule shell. The preparation method comprises the steps of delivery system preparation, capsule shell preparation, capsule forming, quality detection and the like. Intestinal targeted delivery, controllable disintegration and intestinal in-situ emulsification core technologies are integrated to form a synergistic effect, so that active ingredients such as nervonic acid safely pass through the stomach and are accurately released in the intestinal tract to form a nano-scale microemulsion, the bioavailability is improved from less than 20% to more than or equal to 60%, and the nano-scale microemulsion is high in compatibility with an existing production line, controllable in quality, low in industrialization cost and suitable for industrial production. The xanthoceras sorbifolia bunge oil can be promoted to be upgraded to a high-valued functional preparation.

Disclosed in certain embodiments is a delayed release softgel capsules comprise a fill material that is encapsulated in a pH dependent shell composition, the pH dependent shell composition including pectin and gellan gum. Also disclosed are methods of preparing any of the delayed release softgel capsules described herein and methods of use thereof.

The invention belongs to the technical field of health care products or medicines, and discloses a high-purity alkaline compound vitamin C composition, and a liposome soft capsule and a preparation method thereof. The invention firstly provides a composition composed of sodium ascorbate, sodium erythorbate and the like, and the sodium erythorbate and trisodium citrate are utilized to synergistically construct a chemical dual-stability barrier. On the basis, the composition is further encapsulated through a low-temperature oxygen-free liposome preparation process to form a physical protection barrier capable of improving bioavailability, and the composition is prepared into a soft capsule dosage form. According to the preparation method disclosed by the invention, low-temperature and inert gas protection measures run through all the time, and the preparation method not only comprises superfine grinding and mixing of the core composition, but also comprises low-temperature and high-pressure homogenization and subsequent filling processes of the lipidosome. The final product is alkalescent and good in stability, and the absorption rate of active ingredients is remarkably improved through a liposome delivery system.

The invention relates to a chenopodium ambrosioides and adina pilulifera composition enteric-coated preparation and a preparation method thereof. The enteric-coated preparation is prepared from medicinal components and auxiliary materials of chenopodium ambrosioides and adina pilulifera. Comprising enteric soft capsules and enteric dropping pills. The enteric-coated soft capsule is composed of chenopodium ambrosioides, pilularia adina effective components and a first type of auxiliary materials; the enteric-coated dropping pill is composed of chenopodium ambrosioides, pilularia adina effective components and a second type of auxiliary materials. Medicinal components of the chenopodium ambrosioides and the adina pilulifera are volatile oil of the chenopodium ambrosioides and the adina pilulifera, and the volatile oil is extracted according to the following steps of chopping, soaking, wet crushing, solid-liquid separation, distillation and moisture removal to obtain anhydrous volatile oil; the invention provides a chenopodium ambrosioides and adina pilulifera composition enteric-coated preparation which is not easy to dissolve in the stomach and is dissolved after reaching the intestinal tract for treating intestinal diseases, so that the stimulation of the smell of the medicine to the stomach is avoided. The medicine taking compliance of a patient can be improved. The damage of gastric acid to the medicine is avoided, the concentration of medicinal components in the intestinal tract is improved, and the curative effect on intestinal diseases is enhanced.

Provided are a starch film-forming composition and a preparation method of soft capsules thereof. The starch film-forming composition comprises 25-60 wt% of acid-treated starch, 20-40 wt% of a plasticizer and 15-40 wt% of water, wherein the acid-treated starch has a paste viscosity of 5-196 mPa·s, and the paste viscosity is obtained by preparing a 10% w / w starch solution from the acid-treated starch and water, and the acid-treated starch has a phosphate content of 0.01-0.06% (calculated based on phosphorus P). The soft capsules prepared from the starch film-forming composition have a short drying time and uniform moisture, thereby reducing the production cost of the soft capsules.

The application discloses a traditional Chinese medicine composition for resisting heart senility, a soft capsule preparation and a preparation method thereof, and belongs to the technical field of modernized traditional Chinese medicine preparations.The classical prescription Wuling Powder is scientifically combined with Guizhifuling Pill to form the traditional Chinese medicine composition which has the functions of warming yang, promoting water excretion, promoting blood circulation and removing blood stasis, and the traditional Chinese medicine composition is developed into a modernized soft capsule preparation by modern preparation technology.The application innovatively adopts a process in which the inclusion technology and the matrix compound are used to play a synergistic role, and a soft capsule with good stability is prepared.The application overcomes the defects of traditional decoction, such as inconvenience in carrying, unstable components and the like, significantly improves the retention rate of volatile components in the preparation and the stability of the preparation, ensures controllable product quality, and provides a more optimal modernized new traditional Chinese medicine dosage form for the prevention and treatment of heart senility.