287 results about "Softgel" patented technology

The invention relates to a starch-based soft capsule shell and a preparation method thereof. The starch-based soft capsule shell is prepared from the following raw materials in parts by mass: 60 to 70 parts of hydroxypropyl starch, 9 to 20 parts of carrageenan, 5 to 15 parts of diquat, 5 to 15 parts of polylysine, 5 to 10 parts of hydroxypropyl methyl cellulose acetate succinate, 15 to 20 parts of glycerol and 30 to 40 parts of pure water. According to the soft capsule shell, hydroxypropyl starch serves as a base material, gelatin is not added, the conditions of poor weather resistance and fishy smell caused by use of gelatin are avoided, through the synergistic effect of all the components, the defects that a starch-based material is poor in plasticity, fragile and insufficient in mechanical strength are overcome, the structural stability is enhanced through chemical crosslinking, and the mechanical strength is improved; and the mechanical property is improved by virtue of physical compounding, so that the low-temperature resistance, high-temperature resistance and mechanical strength of the capsule skin are improved.

The invention provides a preparation method of a composite soft capsule shell containing plant starch, and belongs to the technical field of soft capsules. The composite soft capsule shell is prepared from the following components in percentage by mass: 15 to 30 percent of gelatin, 5 to 20 percent of modified plant starch, 1 to 15 percent of composite plant gum, 1 to 10 percent of dopamine grafted pulullan, 10 to 30 percent of plasticizer and 25 to 45 percent of solvent; compared with the existing soft capsule skin, the soft capsule skin prepared by the invention has better mechanical strength and toughness, overcomes the problem of disintegration and delayed release caused by a capsule shell crosslinking aging reaction, is beneficial to the preservation of the soft capsule and reduces the storage cost.

The invention provides a quick-release alfacalcidol soft capsule and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the preparation raw materials comprise a PLGA microsphere content containing vitamin D3 and a capsule shell liquid containing beta-cyclodextrin, the preparation method of the quick-release alfacalcidol soft capsule comprises the following steps: preparing the capsule content and the capsule shell liquid into the soft capsule by using a full-automatic soft capsule machine, shaping in cold air at the temperature of 20 DEG C and the humidity of 45%, washing pills, drying and packaging to obtain the alfacalcidol soft capsule.

The invention provides a film-forming composition, a seamless soft capsule shell prepared from the film-forming composition, and a seamless soft capsule containing the soft capsule shell. The film-forming composition comprises: 1%-4% of a first gelling agent; 0.5%-10% of high ester pectin; 0.75 to 15% of a plasticizer; and at least 80% water wherein the first gelling agent is a low acyl gellan gum. The film-forming composition is low in solution viscosity and high in gel strength at room temperature, the seamless soft capsule prepared by dripping the film-forming composition as a film-forming material is high in strength and uniform in appearance, and the dried soft capsule product can be quickly disintegrated in a water medium.

The invention provides a propolis soft capsule which comprises a soft capsule shell and a content wrapped in the soft capsule shell, and the content comprises 400-750 g of propolis extract, 2000-2400 g of vegetable oil, 1000-1400 g of modified starch, 75-100 g of tea seed oil, 50-100 g of natural antioxidant and 75-125 g of cellulose on the basis of 10000 propolis soft capsules. One of the purposes of the invention is to provide the propolis soft capsule and the production process thereof, and by optimizing the formula and the production process of the propolis soft capsule, the purposes of improving the bioavailability, enhancing the stability of the product, improving the mouth feel, improving the safety of the product and improving the environmental friendliness of the product can be achieved on the premise of not influencing the active ingredients of the propolis.

The invention relates to the technical field of biological medicine, in particular to a composition based on dendrobium nobile, a preparation method of the composition and application of the composition to preparation of soft capsules, buccal tablets and oral soluble film preparations, the composition takes dendrobium nobile extract as a main active ingredient, and can be matched with auxiliary materials such as excipients, disintegrating agents and film-forming agents to be optimized into different dosage forms. The soft capsule has a slow release effect, the buccal tablet is convenient to carry and take, and the oral soluble film can realize rapid oral mucosa absorption. The preparation method disclosed by the invention is stable in process and suitable for industrial production, and the obtained preparation has good bioavailability and stability, can be widely applied to the field of health-care foods or medicines, and is particularly suitable for enhancing immunity, resisting oxidation, moistening lung, promoting salivation and the like.

The invention relates to low-viscosity sodium alginate, a preparation method and a soft capsule shell containing a pure sodium alginate component, and belongs to the technical field of biochemical engineering, the viscosity and molecular weight of the low-viscosity sodium alginate are 15mPa. S and 273.08 kDa; the molecular weight is 30 mPa.s and the molecular weight is 310.5 kDa; according to the present invention, the ratio of the Da to 665.43 kDa is 20.48%, the ratio of the Da to 444.79 kDa is 16.87%, and the ratio of the Da to 322.06 kDa is 62.66%; or when the molecular weight is 70 mPa.s, the molecular weight of 466.92 kDa accounts for 44.27%, and the molecular weight of 329.27 kDa accounts for 55.73%. The invention also provides a preparation method of the low-viscosity sodium alginate, which comprises the following steps: dissolving the sodium alginate as a raw material, carrying out enzymolysis by using alginate lyase, sampling at regular time, measuring the viscosity, carrying out enzyme deactivation treatment on the enzymatic hydrolysate when the viscosity reaches the specified viscosity, and carrying out evaporation concentration, alcohol precipitation, drying and crushing to obtain the low-viscosity sodium alginate. The low-viscosity sodium alginate can be used for preparing a soft capsule shell which is stable in property and good in enteric characteristic.

The invention discloses a preparation method of a ganoderma spore oil grifola frondosa soft capsule based on a cold preparation method. The preparation method comprises the following steps: firstly, carrying out high-speed shearing and nanocrystallization treatment on grifola frondosa extract, selenium-enriched yeast, squalene and ganoderma lucidum spore oil for later use; and then melting gelatin, glycerol, water and cocoa shell extract at low temperature to obtain a gelatin solution, and finally preparing the soft capsule. According to the invention, on the basis of ensuring sufficient dissolution of the gelatin, the influence of the traditional gelatin melting temperature on the gel strength, the viscosity, the three-dimensional structure, the production stability and other performances and the application effect can be effectively avoided. Meanwhile, the ganoderma lucidum spore oil, squalene, grifola frondosa extract and selenium-enriched yeast are ingeniously combined, so that the content of a landmark component triterpenoid compound in the content is remarkably increased, and the metabolic detoxification capability of the liver and the anti-inflammatory and immune regulation effects of the body are enhanced.

The invention belongs to the technical field of medicinal materials, and particularly relates to an anti-aging and anti-leakage soft capsule wall material and a preparation method thereof. The soft capsule wall material comprises the following raw materials in percentage by mass: 10%-15% of gelatin, 0.4%-2% of succinic anhydride, 4%-6% of glycerol, 0.08%-0.13% of sodium carboxymethyl cellulose and 78%-85% of purified water. The capsule material provided by the invention can simultaneously solve the problem of slow disintegration caused by an oxidation cross-linking reaction and the problem of leakage caused by strong hygroscopicity in the storage process, is simple in production process and high in safety, and has a very good application prospect in the field of soft capsule preparations.

The invention provides a starch-based soft capsule composition, a starch-based soft capsule and a preparation method of the starch-based soft capsule, and belongs to the technical field of medicines. The starch-based soft capsule composition is characterized by being prepared from the following components in parts by weight: 50 to 100 parts of plant starch, 20 to 100 parts of modified starch, 0.1 to 5 parts of thickening agent and 0.1 to 5 parts of plasticizer, the plant starch comprises pea starch and corn starch in a mass ratio of (10-60): (40-50); the modified starch comprises modified corn starch and modified potato starch in a mass ratio of (1-5): (1-8). The starch-based soft capsule disclosed by the invention is high in joint closing rate; the starch-based soft capsule is high in transparency, not easy to age and good in stability after being stored for a long time.

The invention relates to a method for detecting light liquid paraffin residue in a soft capsule dosage form, which adopts high performance liquid chromatography based on an evaporative light-scattering detector for detection, and comprises the following steps: (1) setting conditions of the high performance liquid chromatography; (2) dissolving an n-octadecane reference substance in dichloromethane to prepare n-octadecane reference substance linear solutions with different gradient concentrations between 28g / mL and 210g / mL, drawing detection results of the high performance liquid chromatography into a standard curve, and fitting to obtain the standard curve; (3) taking the solution in a plurality of soft capsules, putting the solution in a measuring flask, adding dichloromethane for dissolving, and filtering with a 0.22 m filter membrane for later use; and (4) sampling the test solution, then sampling the n-octadecane reference substance solution, comparing the logarithm values of the chromatogram peak areas of the test solution and the reference substance solution, and calculating the concentration of n-octadecane in the sample by an external standard method, thereby obtaining the residual concentration of light liquid paraffin.

The invention is applied to the technical field of health-care products, and discloses a sea-buckthorn soft capsule, which comprises a capsule shell and a content, the capsule shell is composed of gelatin, water, glycerin and an auxiliary material, the auxiliary material is a preservative or a plasticizer, the content is composed of one of seabuckthorn seed oil or fruit oil, seabuckthorn powder and an auxiliary material, the auxiliary material is one of a suspending aid and an antioxidant or a mixture of the suspending aid and the antioxidant, the seabuckthorn powder is rich in flavone, and the auxiliary material is a mixture of the suspending aid and the antioxidant. The soft capsule has the effects of lowering lipid, softening blood vessels and preventing vascular diseases. According to the hippophae rhamnoides soft capsule, a product capsule shell is prepared from gelatin, water and glycerin according to a specific proportion, it can be guaranteed that the capsule shell has proper hardness and elasticity and is convenient to process and store, hippophae rhamnoides seed (fruit) oil and hippophae rhamnoides powder in the content are matched according to a reasonable proportion, the hippophae rhamnoides powder is rich in flavone, and the hippophae rhamnoides powder and the hippophae rhamnoides seed (fruit) oil act the effects of lowering lipid, softening blood vessels and preventing vascular diseases can be better exerted.

The invention provides a gastrodia elata and spina date seed oil soft capsule and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine extraction and preparation.The preparation method of the gastrodia elata and spina date seed oil soft capsule comprises the following steps that 1, spina date seed coarse powder is pre-extracted with an organic solvent to obtain spina date seed oil and spina date seed residues, and the spina date seed oil is obtained; granulating the spina date seed residues to obtain spina date seed residue particles; 2) extracting the spina date seed residue particles for 2-4 times by using the organic solvent to obtain spina date seed oil and waste residues; 3) mixing the waste residues with gastrodia elata, performing water extraction to obtain a gastrodia elata-spina date seed water extract, and performing concentration and spray drying to obtain a gastrodia elata-spina date seed dry extract; and 4) taking soybean oil and the spina date seed oil as auxiliaries, and taking the gastrodia elata-spina date seed dry extract as a solute to prepare soft capsule contents, thereby obtaining the gastrodia elata-spina date seed oil soft capsule. The gastrodia elata and spina date seed oil soft capsule prepared by the preparation method disclosed by the invention has a remarkable effect of improving sleep.

The present invention discloses a preparation method of Ganoderma lucidum spore oil and Grifola frondosa soft capsules based on a cold preparation method. First, Grifola frondosa extract, selenium-enriched yeast, squalene, and Ganoderma lucidum spore oil are subjected to high-speed shear nano-processing and then set aside; subsequently, gelatin is subjected to low-temperature gelation with glycerol, water, and cocoa shell extract to obtain a gelatin solution, and finally, soft capsules are prepared. While ensuring that gelatin is fully dissolved, the present invention effectively avoids the impact of traditional gelation temperature on gel strength, viscosity, three-dimensional structure, production stability, and other properties and application effects. At the same time, the Ganoderma lucidum spore oil and squalene, Grifola frondosa extract, and selenium-enriched yeast are cleverly combined to significantly increase the content of triterpenoid compounds, a characteristic component in the contents, thereby enhancing the liver's metabolic detoxification ability and the body's anti-inflammatory and immunomodulatory effects.

The invention discloses high-steady-state vitamin B1 micro-capsule powder applied to soft capsules and a preparation method. The micro-capsule powder is prepared from the following raw materials in parts by weight: 10-65 parts of a vitamin B1 core material, 10-30 parts of a wall material, 0.5-2 parts of a small molecular emulsifier and 5-35 parts of a filler, the wall material is prepared from starch sodium octenylsuccinate and pectin in a mass ratio of (1.5-5): 1; and the mass ratio of the wall material to the core material is not greater than 1: 2.3. Compared with the prior art, the vitamin B1 microcapsule powder prepared by the invention can effectively delay degradation of vitamin B1 in soft capsules and solve the problem that the vitamin B1 soft capsules are unstable within the shelf life, has higher stability in the soft capsules, meanwhile, the loading capacity of effective components is higher, and the production efficiency is greatly improved.

The invention discloses an astaxanthin soft capsule and a preparation process thereof, and belongs to the technical field of functional food, the soft capsule comprises a capsule core and a capsule wall; the capsule core is prepared from the following components in parts by mass: 90 to 95 parts of astaxanthin oil, 60 to 64 parts of linseed oil, 8 to 12 parts of gamma-aminobutyric acid and 3 to 5 parts of beewax; the capsule wall comprises the following components in parts by mass: 36-40 parts of gelatin, 20-24 parts of glycerol, 5-7 parts of black pepper extract and 36-40 parts of purified water. The soft capsule obtained by processing the capsule core and capsule wall materials has the advantages of high stability and good disintegration effect.

The invention discloses a soft capsule coating agent which comprises the following components in percentage by mass: 40-60% of pectin, 15-30% of a humectant, 10-20% of medium chain triglyceride, 10-20% of carnauba wax, 5-10% of hydroxypropyl methyl cellulose and 0.1-10% of glycerol, wherein the humectant is prepared from at least one of sorbitol, xylitol and isomaltitol. The invention also discloses a preparation method of the soft capsule coating agent and a soft capsule containing the soft capsule coating agent. According to the soft capsule coating agent disclosed by the invention, the problems of high-temperature and high-humidity deformation and caking of soft capsules and aging of capsule skins after long-time storage can be improved, and meanwhile, the soft capsule coating agent is good in barrier property and better in protection of soft capsule products.

The invention belongs to the field of substance content detection, and discloses a method for determining the content of soybean phosphatidylcholine or phosphatidylethanolamine in a soft capsule, which comprises the following steps: (1) preparing a soybean phosphatidylcholine or phosphatidylethanolamine standard solution; (2) preparing a to-be-detected sample solution; (3) performing high performance liquid chromatography analysis; (4) drawing a standard curve; and (5) calculating the content of soybean phosphatidylcholine or phosphatidyl ethanolamine. The method has the advantages of high response value, short retention time and stable base line, and is not interfered by other components in the soft capsule; the method has the advantages of simple operation, high precision and good repeatability, the recovery rate meets the analysis requirement, and the method can efficiently, quickly and accurately detect the content of two components, namely soybean phosphatidylcholine and phosphatidyl ethanolamine, of soybean phospholipid in the soft capsule content.

The invention provides an ethyl eicosapentaenoate soft capsule as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The ethyl eicosapentaenoate soft capsule comprises a content and a capsule shell, the content is prepared from the following components in parts by mass: 10 to 30 parts of ethyl eicosapentaenoate, 40 to 70 parts of oil phase matrix, 5 to 15 parts of emulsifier, 2 to 8 parts of antioxidant composition and 0 to 5 parts of cosolvent; the capsule shell comprises the following components in parts by mass: 40-60 parts of gelatin, 25-40 parts of a plasticizer, 20-35 parts of water, 0.5-3 parts of an opacifying agent and 0.1-1 part of an antioxidant. The invention provides the ethyl eicosapentaenoate soft capsule with excellent stability and safety and the preparation method thereof, and the technical problem that EPA-E is easy to oxidize is successfully solved by matching with an optimized anti-oxidation system and process parameters.

The invention belongs to the technical field of oral medicine preparations, and particularly relates to a microcrystal suspension multi-ball soft capsule and a preparation method and application thereof.The microcrystal suspension multi-ball soft capsule is of a three-level structure formed by a shell, temperature-sensitive hydrogel and medicine-carrying microcrystal balls, and the medicine-carrying microcrystal balls are in a three-level structure under the spatial constraint effect of the temperature-sensitive hydrogel. The medicine-carrying microcrystalline balls are prevented from settling or freely moving; after the medicine is orally taken and enters a body, the shell is rapidly disintegrated, the temperature-sensitive hydrogel is slowly corroded, the medicine-carrying microcrystalline balls are released accordingly, and it is ensured that the medicine nanocrystals are stably dissolved out. Besides, in the preparation process, only conventional equipment, such as a high-pressure homogenizer and a soft capsule pressing machine, is needed, and a special nano synthesis or crosslinking process is not needed; the preparation process is easy to control and meets the large-scale production requirement.

The application belongs to the technical field of soft capsules, and discloses a starch-based soft capsule material and a preparation method thereof. The preparation method comprises the following steps: mixing wheat starch and deionized water, adding a sodium periodate solution to react, so as to obtain dialdehyde starch; reacting the dialdehyde starch with glycidyl methacrylate and triethylamine, so as to obtain grafted modified starch; mixing the grafted modified starch with modified nano-silicon dioxide, and reacting after ultrasonic oscillation, so as to obtain nano-silicon dioxide composite modified starch; mixing the composite modified starch with polyvinyl alcohol and polyvinylpyrrolidone, so as to obtain a film forming solution; and after the film forming solution is cast and dried, hot pressing is performed, so that the starch-based soft capsule material is finally obtained. The starch is subjected to multiple hydrophobic modifications, so that the hydrophilic performance is reduced, and the stability of the soft capsule is improved.

Softgel capsules have a liquid fill composition of 30% to 40% wt / wt of an edible oil or edible fat; 0.2% to 30% wt / wt of a mineral acetate powder, with the proviso that the mineral acetate powder does not comprise disodium acetate; 1% to 8% wt / wt of one or a combination of a suspending agent and / or a wetting agent; and apple cider vinegar powder as a balance of the liquid fill material encapsulated in an outer softgel shell.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

The invention discloses a soft capsule containing a ginkgo leaf extract and preparation equipment, and relates to the field of ginkgo leaf extraction. The preparation equipment of the soft capsule containing the ginkgo biloba extract comprises an extraction tank and a fermentation tank, and further comprises a spiral groove formed in the fermentation tank; the air bag is connected into the fermentation tank in a sliding manner; the air bag capable of moving up and down and rotating is arranged in the fermentation tank, the stirring rod on the air bag is used for stirring the fermented material, the fermented material is uniformly fermented, suction force can be generated through the grinding shaft rotating along the side wall of the extraction tank, ginkgo leaves floating in water are adsorbed, and the fermentation effect is improved. And then the ginkgo leaves are in contact with the side wall of the extraction tank for extrusion, water is discharged, the ginkgo leaves do not need to be fished out, the ginkgo leaves on the grinding shaft do not need to be cleaned, the working efficiency is improved, and extraction of the ginkgo leaves is facilitated.

This invention provides a starch-based soft capsule composition, a starch-based soft capsule, and a method for preparing the same, belonging to the field of pharmaceutical technology. The starch-based soft capsule composition is characterized by comprising, by weight, 50-100 parts plant starch, 20-100 parts modified starch, 0.1-5 parts thickener, and 0.1-5 parts plasticizer; the plant starch is pea starch and corn starch in a mass ratio of (10-60):(40-50); the modified starch is modified corn starch and modified potato starch in a mass ratio of (1-5):(1-8). The starch-based soft capsules of this invention have a high seam sealing rate; they exhibit high transparency after long-term storage, are not prone to aging, and have good stability.

The invention relates to the technical field of biological medicine preparations, and discloses a calcium, vitamin D and vitamin K. A content composition of the soft capsule comprises a microgel skeleton composed of amphiphilic polypeptide calcium ions and vitamin oil drops, the hydrophobic end of amphiphilic polypeptide adsorbs the oil drops, and the hydrophobic end of the amphiphilic polypeptide adsorbs the vitamin oil drops. A hydrophilic end of the composition is bridged by calcium ions to form a network, the composition also comprises a histidine-enriched polypeptide which can form a protective shielding layer on the surface of a skeleton under acidic pH, the calcium ions are converted from a chemical destroyer to a structural stabilizer, and a static synergistic system is constructed, so that the contact degradation of calcium and vitamins is eliminated, and the stability of the composition is improved. The performance contradiction between the high calcium content and the vitamin stability is avoided, and the endophytic environmental adaptability of the composition is improved.

To provide improved non-animal softgel capsule formulations that have shorter dissolution and / or disintegration times.SOLUTION: A shell composition is provided which has a non-animal derived gelling agent and a water-soluble polymer. The shell composition completely dissolves in less than 30 minutes when subject to a dissolution with a USP Apparatus II with paddles at 75 RPM in 900 ml of 0.1 N HCl and deionized water at 37°C. Also provided is a softgel composition comprising a fill material encapsulated within the shell composition.SELECTED DRAWING: None

The invention relates to a soft capsule, in particular to a long-acting DHA soft capsule and a preparation method thereof. The long-acting DHA soft capsule is prepared from the following raw materials in parts by weight: 10 to 11 parts of xanthan gum, 3 to 4 parts of locust bean gum, 0.5 to 1 part of sericin, 0.5 part of glycerol and 13.5 to 16 parts of deionized water. The preparation method comprises the following steps: stirring and heating to 75-80 DEG C until all the raw materials are dissolved in water or melted and solid particles visible to naked eyes do not exist, so that the raw materials are glue liquid; spreading the glue solution into a rubber sheet; pressing the capsule skin and the DHA grease composition into capsules through a soft capsule pelleting machine; after shaping, polishing and drying to obtain the long-acting DHA soft capsule. The capsule skin of the long-acting DHA soft capsule is of a single-layer structure, the structure is simple, the physicochemical property is determined, a traditional soft capsule pelleting machine can be used for pressing, an additional secondary coating process is not needed, and the production process is simplified; through cooperation of xanthan gum and locust bean gum, the gum skin keeps certain dimensional stability in a freezing environment.

The invention provides a soft capsule shell, which is prepared from the following raw materials in parts by weight: 10 to 20 parts of modified gelling agent, 40 to 80 parts of modified starch, 2 to 6 parts of thickening agent, 1 to 4 parts of antioxidant, 25 to 40 parts of plasticizer and 80 to 120 parts of deionized water. The modified gelling agent is prepared from seaweed gel, microbial gum and edible gum in a mass ratio of 1: (1.3-1.6): (2-3). The seaweed gel is agar or carrageenan; the microbial gum is gellan gum or xanthan gum; the edible gum is pectin or konjac gum; the prepared soft capsule shell has good tensile strength, elongation at break and other properties, and has good enteric solubility.

The present application belongs to the field of pharmaceutical analysis, and particularly relates to a dissolution determination method for soft capsule preparation, which installs a screen on the upper side of the stirring paddle of a dissolution device, so that when the soft capsule shell has a large crack and large oil drops appear, the large oil drops can be dispersed into small droplets through the screen, thereby ensuring that the drug dispersion measurement result in the dissolution cup is scientific and reasonable.