226 results about "Softgel" patented technology

The invention relates to a starch-based soft capsule shell and a preparation method thereof. The starch-based soft capsule shell is prepared from the following raw materials in parts by mass: 60 to 70 parts of hydroxypropyl starch, 9 to 20 parts of carrageenan, 5 to 15 parts of diquat, 5 to 15 parts of polylysine, 5 to 10 parts of hydroxypropyl methyl cellulose acetate succinate, 15 to 20 parts of glycerol and 30 to 40 parts of pure water. According to the soft capsule shell, hydroxypropyl starch serves as a base material, gelatin is not added, the conditions of poor weather resistance and fishy smell caused by use of gelatin are avoided, through the synergistic effect of all the components, the defects that a starch-based material is poor in plasticity, fragile and insufficient in mechanical strength are overcome, the structural stability is enhanced through chemical crosslinking, and the mechanical strength is improved; and the mechanical property is improved by virtue of physical compounding, so that the low-temperature resistance, high-temperature resistance and mechanical strength of the capsule skin are improved.

The invention relates to the technical field of biological medicine, in particular to a composition based on dendrobium nobile, a preparation method of the composition and application of the composition to preparation of soft capsules, buccal tablets and oral soluble film preparations, the composition takes dendrobium nobile extract as a main active ingredient, and can be matched with auxiliary materials such as excipients, disintegrating agents and film-forming agents to be optimized into different dosage forms. The soft capsule has a slow release effect, the buccal tablet is convenient to carry and take, and the oral soluble film can realize rapid oral mucosa absorption. The preparation method disclosed by the invention is stable in process and suitable for industrial production, and the obtained preparation has good bioavailability and stability, can be widely applied to the field of health-care foods or medicines, and is particularly suitable for enhancing immunity, resisting oxidation, moistening lung, promoting salivation and the like.

The invention discloses a preparation method of a ganoderma spore oil grifola frondosa soft capsule based on a cold preparation method. The preparation method comprises the following steps: firstly, carrying out high-speed shearing and nanocrystallization treatment on grifola frondosa extract, selenium-enriched yeast, squalene and ganoderma lucidum spore oil for later use; and then melting gelatin, glycerol, water and cocoa shell extract at low temperature to obtain a gelatin solution, and finally preparing the soft capsule. According to the invention, on the basis of ensuring sufficient dissolution of the gelatin, the influence of the traditional gelatin melting temperature on the gel strength, the viscosity, the three-dimensional structure, the production stability and other performances and the application effect can be effectively avoided. Meanwhile, the ganoderma lucidum spore oil, squalene, grifola frondosa extract and selenium-enriched yeast are ingeniously combined, so that the content of a landmark component triterpenoid compound in the content is remarkably increased, and the metabolic detoxification capability of the liver and the anti-inflammatory and immune regulation effects of the body are enhanced.

The invention provides a starch-based soft capsule composition, a starch-based soft capsule and a preparation method of the starch-based soft capsule, and belongs to the technical field of medicines. The starch-based soft capsule composition is characterized by being prepared from the following components in parts by weight: 50 to 100 parts of plant starch, 20 to 100 parts of modified starch, 0.1 to 5 parts of thickening agent and 0.1 to 5 parts of plasticizer, the plant starch comprises pea starch and corn starch in a mass ratio of (10-60): (40-50); the modified starch comprises modified corn starch and modified potato starch in a mass ratio of (1-5): (1-8). The starch-based soft capsule disclosed by the invention is high in joint closing rate; the starch-based soft capsule is high in transparency, not easy to age and good in stability after being stored for a long time.

The invention is applied to the technical field of health-care products, and discloses a sea-buckthorn soft capsule, which comprises a capsule shell and a content, the capsule shell is composed of gelatin, water, glycerin and an auxiliary material, the auxiliary material is a preservative or a plasticizer, the content is composed of one of seabuckthorn seed oil or fruit oil, seabuckthorn powder and an auxiliary material, the auxiliary material is one of a suspending aid and an antioxidant or a mixture of the suspending aid and the antioxidant, the seabuckthorn powder is rich in flavone, and the auxiliary material is a mixture of the suspending aid and the antioxidant. The soft capsule has the effects of lowering lipid, softening blood vessels and preventing vascular diseases. According to the hippophae rhamnoides soft capsule, a product capsule shell is prepared from gelatin, water and glycerin according to a specific proportion, it can be guaranteed that the capsule shell has proper hardness and elasticity and is convenient to process and store, hippophae rhamnoides seed (fruit) oil and hippophae rhamnoides powder in the content are matched according to a reasonable proportion, the hippophae rhamnoides powder is rich in flavone, and the hippophae rhamnoides powder and the hippophae rhamnoides seed (fruit) oil act the effects of lowering lipid, softening blood vessels and preventing vascular diseases can be better exerted.

The invention provides a gastrodia elata and spina date seed oil soft capsule and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine extraction and preparation.The preparation method of the gastrodia elata and spina date seed oil soft capsule comprises the following steps that 1, spina date seed coarse powder is pre-extracted with an organic solvent to obtain spina date seed oil and spina date seed residues, and the spina date seed oil is obtained; granulating the spina date seed residues to obtain spina date seed residue particles; 2) extracting the spina date seed residue particles for 2-4 times by using the organic solvent to obtain spina date seed oil and waste residues; 3) mixing the waste residues with gastrodia elata, performing water extraction to obtain a gastrodia elata-spina date seed water extract, and performing concentration and spray drying to obtain a gastrodia elata-spina date seed dry extract; and 4) taking soybean oil and the spina date seed oil as auxiliaries, and taking the gastrodia elata-spina date seed dry extract as a solute to prepare soft capsule contents, thereby obtaining the gastrodia elata-spina date seed oil soft capsule. The gastrodia elata and spina date seed oil soft capsule prepared by the preparation method disclosed by the invention has a remarkable effect of improving sleep.

The present invention discloses a preparation method of Ganoderma lucidum spore oil and Grifola frondosa soft capsules based on a cold preparation method. First, Grifola frondosa extract, selenium-enriched yeast, squalene, and Ganoderma lucidum spore oil are subjected to high-speed shear nano-processing and then set aside; subsequently, gelatin is subjected to low-temperature gelation with glycerol, water, and cocoa shell extract to obtain a gelatin solution, and finally, soft capsules are prepared. While ensuring that gelatin is fully dissolved, the present invention effectively avoids the impact of traditional gelation temperature on gel strength, viscosity, three-dimensional structure, production stability, and other properties and application effects. At the same time, the Ganoderma lucidum spore oil and squalene, Grifola frondosa extract, and selenium-enriched yeast are cleverly combined to significantly increase the content of triterpenoid compounds, a characteristic component in the contents, thereby enhancing the liver's metabolic detoxification ability and the body's anti-inflammatory and immunomodulatory effects.

The invention discloses an astaxanthin soft capsule and a preparation process thereof, and belongs to the technical field of functional food, the soft capsule comprises a capsule core and a capsule wall; the capsule core is prepared from the following components in parts by mass: 90 to 95 parts of astaxanthin oil, 60 to 64 parts of linseed oil, 8 to 12 parts of gamma-aminobutyric acid and 3 to 5 parts of beewax; the capsule wall comprises the following components in parts by mass: 36-40 parts of gelatin, 20-24 parts of glycerol, 5-7 parts of black pepper extract and 36-40 parts of purified water. The soft capsule obtained by processing the capsule core and capsule wall materials has the advantages of high stability and good disintegration effect.

The invention provides an ethyl eicosapentaenoate soft capsule as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The ethyl eicosapentaenoate soft capsule comprises a content and a capsule shell, the content is prepared from the following components in parts by mass: 10 to 30 parts of ethyl eicosapentaenoate, 40 to 70 parts of oil phase matrix, 5 to 15 parts of emulsifier, 2 to 8 parts of antioxidant composition and 0 to 5 parts of cosolvent; the capsule shell comprises the following components in parts by mass: 40-60 parts of gelatin, 25-40 parts of a plasticizer, 20-35 parts of water, 0.5-3 parts of an opacifying agent and 0.1-1 part of an antioxidant. The invention provides the ethyl eicosapentaenoate soft capsule with excellent stability and safety and the preparation method thereof, and the technical problem that EPA-E is easy to oxidize is successfully solved by matching with an optimized anti-oxidation system and process parameters.

The invention belongs to the technical field of oral medicine preparations, and particularly relates to a microcrystal suspension multi-ball soft capsule and a preparation method and application thereof.The microcrystal suspension multi-ball soft capsule is of a three-level structure formed by a shell, temperature-sensitive hydrogel and medicine-carrying microcrystal balls, and the medicine-carrying microcrystal balls are in a three-level structure under the spatial constraint effect of the temperature-sensitive hydrogel. The medicine-carrying microcrystalline balls are prevented from settling or freely moving; after the medicine is orally taken and enters a body, the shell is rapidly disintegrated, the temperature-sensitive hydrogel is slowly corroded, the medicine-carrying microcrystalline balls are released accordingly, and it is ensured that the medicine nanocrystals are stably dissolved out. Besides, in the preparation process, only conventional equipment, such as a high-pressure homogenizer and a soft capsule pressing machine, is needed, and a special nano synthesis or crosslinking process is not needed; the preparation process is easy to control and meets the large-scale production requirement.

The application belongs to the technical field of soft capsules, and discloses a starch-based soft capsule material and a preparation method thereof. The preparation method comprises the following steps: mixing wheat starch and deionized water, adding a sodium periodate solution to react, so as to obtain dialdehyde starch; reacting the dialdehyde starch with glycidyl methacrylate and triethylamine, so as to obtain grafted modified starch; mixing the grafted modified starch with modified nano-silicon dioxide, and reacting after ultrasonic oscillation, so as to obtain nano-silicon dioxide composite modified starch; mixing the composite modified starch with polyvinyl alcohol and polyvinylpyrrolidone, so as to obtain a film forming solution; and after the film forming solution is cast and dried, hot pressing is performed, so that the starch-based soft capsule material is finally obtained. The starch is subjected to multiple hydrophobic modifications, so that the hydrophilic performance is reduced, and the stability of the soft capsule is improved.

Softgel capsules have a liquid fill composition of 30% to 40% wt / wt of an edible oil or edible fat; 0.2% to 30% wt / wt of a mineral acetate powder, with the proviso that the mineral acetate powder does not comprise disodium acetate; 1% to 8% wt / wt of one or a combination of a suspending agent and / or a wetting agent; and apple cider vinegar powder as a balance of the liquid fill material encapsulated in an outer softgel shell.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

The invention discloses a soft capsule containing a ginkgo leaf extract and preparation equipment, and relates to the field of ginkgo leaf extraction. The preparation equipment of the soft capsule containing the ginkgo biloba extract comprises an extraction tank and a fermentation tank, and further comprises a spiral groove formed in the fermentation tank; the air bag is connected into the fermentation tank in a sliding manner; the air bag capable of moving up and down and rotating is arranged in the fermentation tank, the stirring rod on the air bag is used for stirring the fermented material, the fermented material is uniformly fermented, suction force can be generated through the grinding shaft rotating along the side wall of the extraction tank, ginkgo leaves floating in water are adsorbed, and the fermentation effect is improved. And then the ginkgo leaves are in contact with the side wall of the extraction tank for extrusion, water is discharged, the ginkgo leaves do not need to be fished out, the ginkgo leaves on the grinding shaft do not need to be cleaned, the working efficiency is improved, and extraction of the ginkgo leaves is facilitated.

This invention provides a starch-based soft capsule composition, a starch-based soft capsule, and a method for preparing the same, belonging to the field of pharmaceutical technology. The starch-based soft capsule composition is characterized by comprising, by weight, 50-100 parts plant starch, 20-100 parts modified starch, 0.1-5 parts thickener, and 0.1-5 parts plasticizer; the plant starch is pea starch and corn starch in a mass ratio of (10-60):(40-50); the modified starch is modified corn starch and modified potato starch in a mass ratio of (1-5):(1-8). The starch-based soft capsules of this invention have a high seam sealing rate; they exhibit high transparency after long-term storage, are not prone to aging, and have good stability.

The invention relates to the technical field of biological medicine preparations, and discloses a calcium, vitamin D and vitamin K. A content composition of the soft capsule comprises a microgel skeleton composed of amphiphilic polypeptide calcium ions and vitamin oil drops, the hydrophobic end of amphiphilic polypeptide adsorbs the oil drops, and the hydrophobic end of the amphiphilic polypeptide adsorbs the vitamin oil drops. A hydrophilic end of the composition is bridged by calcium ions to form a network, the composition also comprises a histidine-enriched polypeptide which can form a protective shielding layer on the surface of a skeleton under acidic pH, the calcium ions are converted from a chemical destroyer to a structural stabilizer, and a static synergistic system is constructed, so that the contact degradation of calcium and vitamins is eliminated, and the stability of the composition is improved. The performance contradiction between the high calcium content and the vitamin stability is avoided, and the endophytic environmental adaptability of the composition is improved.

To provide improved non-animal softgel capsule formulations that have shorter dissolution and / or disintegration times.SOLUTION: A shell composition is provided which has a non-animal derived gelling agent and a water-soluble polymer. The shell composition completely dissolves in less than 30 minutes when subject to a dissolution with a USP Apparatus II with paddles at 75 RPM in 900 ml of 0.1 N HCl and deionized water at 37°C. Also provided is a softgel composition comprising a fill material encapsulated within the shell composition.SELECTED DRAWING: None

The invention relates to a soft capsule, in particular to a long-acting DHA soft capsule and a preparation method thereof. The long-acting DHA soft capsule is prepared from the following raw materials in parts by weight: 10 to 11 parts of xanthan gum, 3 to 4 parts of locust bean gum, 0.5 to 1 part of sericin, 0.5 part of glycerol and 13.5 to 16 parts of deionized water. The preparation method comprises the following steps: stirring and heating to 75-80 DEG C until all the raw materials are dissolved in water or melted and solid particles visible to naked eyes do not exist, so that the raw materials are glue liquid; spreading the glue solution into a rubber sheet; pressing the capsule skin and the DHA grease composition into capsules through a soft capsule pelleting machine; after shaping, polishing and drying to obtain the long-acting DHA soft capsule. The capsule skin of the long-acting DHA soft capsule is of a single-layer structure, the structure is simple, the physicochemical property is determined, a traditional soft capsule pelleting machine can be used for pressing, an additional secondary coating process is not needed, and the production process is simplified; through cooperation of xanthan gum and locust bean gum, the gum skin keeps certain dimensional stability in a freezing environment.

The present application belongs to the field of pharmaceutical analysis, and particularly relates to a dissolution determination method for soft capsule preparation, which installs a screen on the upper side of the stirring paddle of a dissolution device, so that when the soft capsule shell has a large crack and large oil drops appear, the large oil drops can be dispersed into small droplets through the screen, thereby ensuring that the drug dispersion measurement result in the dissolution cup is scientific and reasonable.

The invention belongs to the field of propolis soft capsules, and provides a propolis soft capsule and a preparation method thereof.The propolis soft capsule is prepared from, by weight, 30%-50% of propolis extract, 40%-60% of modified egg yolk phospholipid and 5%-15% of cosolvent; wherein the modified egg yolk phospholipid is partially hydrogenated, the sn-2 site of the modified egg yolk phospholipid is substituted by branched chain fatty acid, and the iodine value of the modified egg yolk phospholipid is shown in the specification; according to the invention, specifically modified egg yolk phospholipid is used as a core carrier, and the unique molecular structure of the egg yolk phospholipid can be efficiently self-assembled in an oil phase, so that the egg yolk phospholipid has excellent wrapping and solubilizing capabilities on various active components in propolis. The propolis extract can be stably loaded into an oil phase to form a transparent nano-dispersion with small average particle size and low polydispersity index, so that high-efficiency and high-loading oil dissolution of propolis is realized, and a stable nano-dispersion system is formed.

The invention discloses a rosa roxburghii tratt fruit and ganoderma lucidum soft capsule for enhancing immunity and a preparation method thereof, and relates to the technical field of health-care food, the rosa roxburghii tratt fruit and ganoderma lucidum soft capsule comprises a content and a capsule shell wrapping the content; the content is prepared from the following components in parts by weight: 55 to 65 parts of roxburgh rose juice concentrated powder, 55 to 65 parts of lucid ganoderma extract, 350 to 380 parts of camellia oleosa seed oil and 12 to 18 parts of beewax; the capsule shell is prepared from the following components in parts by weight: 115 to 125 parts of gelatin, 115 to 125 parts of purified water, 2.5 to 3.5 parts of caramel color, 0.2 to 0.4 part of titanium dioxide and 0.015 to 0.025 part of brown iron oxide; the purpose of preparing the immunoregulation roxburgh rose and lucid ganoderma soft capsule which is definite in effect, high in stability, convenient and fast to take and suitable for industrial production is achieved through precise proportioning of the roxburgh rose juice concentrated powder and the lucid ganoderma extract, optimization of an auxiliary material system and precise processes of colloid mill grinding, temperature difference pelleting, gradient drying and the like.

This specification describes softgel capsules comprising a filler material and a shell composition. The filler material may contain alkali metal salts of NSAIDs and acetaminophen, but may not contain povidone. The shell composition may contain a film-forming material. The softgel capsules may have at least about 99% assay stability at room temperature after 12 months.

The application discloses a gelatin soft capsule continuous production process. The process uses a vacuum stirring defoaming device to actively defoam the glue solution, and adds a monitoring point after defoaming. According to the real-time situation, the process parameters are adjusted, so that the defoamed gelatin can reach the production standard without standing, thereby further completing the continuous production of the gelatin soft capsule. The application has important significance for improving the yield and quality of the soft capsule.

The present application relates to the technical field of medicine, in particular to a kind of preparation and application of self-microemulsifying composition containing lamotrigine.The self-microemulsifying composition includes lamotrigine and self-microemulsifying drug delivery system (SMEDDS) carrier;The SMEDDS carrier includes: by lamotrigine, oil phase, emulsifier and co-emulsifier;The self-microemulsifying composition, by mass ratio, lamotrigine is 0.1% to 18.7%, oil phase is 20% to 33%, milk phase is 67% to 80%, the milk phase is by emulsifier and co-emulsifier, and the mass ratio of emulsifier and co-emulsifier is 25.7 to 32.9%:67.1% to 74.3%, and the mass concentration of lamotrigine reaches 18.7%.The particle size of microemulsion formed by the self-microemulsifying composition dispersed in aqueous medium is less than 50nm or even smaller.The self-microemulsifying composition is prepared into soft capsule, hard capsule, tablet, granule, temperature-sensitive gel and other dosage forms, and is applied in the preparation of antiepileptic drugs.

The invention belongs to the field of medical technology and pharmaceutic adjuvant materials, and particularly provides a starch-based soft capsule with high starch proportion (60-72%, w / w) and high forming rate (greater than or equal to 92%), a formula of the starch-based soft capsule, a continuous production process of the starch-based soft capsule and application of the starch-based soft capsule. The starch-based soft capsule overcomes the defects of a traditional soft capsule wall material (mainly animal-derived gelatin), green sustainable materials such as modified starch are used as main solid raw materials and cooperate with a plasticizer formula, reagents such as a disintegrating agent and a release agent are not added, components of the starch-based soft capsule are greatly simplified, and the preparation method is simple and convenient. The problem of compatibility between different components of the soft capsule and filling contents is reduced; and the filling amount of the contents of the soft capsule is increased, and the problem of friability / hardness caused by starch retrogradation is delayed. The invention also provides a novel preparation method of the starch-based soft capsule, and the starch-based soft capsule with high starch proportion, which meets the standard requirements of soft capsules in Chinese pharmacopoeia, and is low in price, high in transparency, high in forming rate (greater than or equal to 92%), strong in packaging property, strong in stability, good in flexibility, green and safe, is obtained. The method has a huge application prospect in the aspects of pharmaceutical preparations, food packaging materials, health-care product packaging materials, cosmetic packaging materials and the like.

The invention belongs to the technical field of soft capsules, and discloses a starch-based soft capsule material and a preparation method thereof. Comprising the following steps: mixing wheat starch with deionized water, and adding a sodium periodate solution for reaction to obtain dialdehyde starch; reacting the dialdehyde starch with glycidyl methacrylate and triethylamine to obtain grafted modified starch; mixing the grafted modified starch with the modified nano silicon dioxide, carrying out ultrasonic oscillation, and reacting to obtain nano silicon dioxide composite modified starch; mixing the composite modified starch with polyvinyl alcohol and polyvinylpyrrolidone to prepare a membrane preparation solution; and carrying out tape casting and drying on the film-making liquid, and carrying out hot press molding to finally obtain the starch-based soft capsule material. The starch is subjected to multiple hydrophobic modification, and the hydrophilic performance of the starch is reduced, so that the stability of the soft capsule is improved.

The invention relates to the technical field of pharmaceutical preparations, in particular to an EPA phospholipid soft capsule composition and a preparation method thereof.The composition comprises EPA phospholipid and an enteric soft capsule shell, the EPA phospholipid is prepared from EPA ethyl ester and a reaction substrate under the action of immobilized phospholipase, and the enteric soft capsule shell comprises an enteric material, a plasticizer and purified water. According to the EPA phospholipid enteric-coated soft capsule provided by the invention, EPA ethyl ester is phosphatidylated, and EPA phospholipid is prepared into the enteric-coated soft capsule, so that stable retention of a medicine in the stomach can be reduced, accurate dissolution of the medicine in the small intestine is realized, the problems of peculiar smell and degradation caused by release of EPA ethyl ester in the stomach are effectively avoided, and the EPA phospholipid enteric-coated soft capsule has the characteristic of pH-enzyme dual response.

The invention discloses a preparation method and application of a soft capsule containing (R)-3-hydroxybutyric acid. The preparation method comprises the following steps: S1, mixing an (R)-3-hydroxybutyric acid solution with a porous material, drying and sieving to obtain composite solid powder; wherein the porous material is selected from any one of gel silicon dioxide, porous starch and isomaltitol; s2, adding a thickening agent into an oily solvent, dissolving, then sequentially adding an antioxidant and the composite solid powder, and uniformly mixing to obtain a soft capsule content; and S3, under a heating condition, mixing glycerol, water, gelatin and an opacifying agent, dissolving and defoaming to obtain a capsule skin glue solution, pelleting the capsule skin glue solution and the soft capsule content through a pelleting machine, and drying to obtain the soft capsule. The soft capsule prepared by the method disclosed by the invention can effectively avoid the corrosion effect of (R)-3-hydroxybutyric acid on the capsule shell, is beneficial to improving the stability, and is simple in preparation process and suitable for industrial production.

The application discloses a liposome curcumin composition for assisting in controlling blood sugar and regulating kidney and application thereof, and belongs to the technical field of food and health food. The composition adopts a modular formula design and comprises a basic active component and an optional kidney protection component. The particle size of the liposome curcumin is accurately controlled to be 60-80 nm, the encapsulation rate is greater than or equal to 80%, the ethanol residue is less than or equal to 0.5 ‰, the gastric juice 2h release rate is less than 33%, and the intestinal juice 2h release rate is greater than 80%. By differentially adjusting the component amount, two scenes of simple blood sugar reduction and blood sugar reduction and kidney protection can be adapted, and bidirectional synergy of stable blood sugar regulation and kidney target maintenance can be realized. The application also provides application of the composition in oral liquid, solid beverage, soft capsule and tablet. It is verified through experiments that the bioavailability of the composition is more than 12 times higher than that of conventional curcumin preparation, the postprandial blood sugar peak value is reduced by 25%-30%, the urinary protein excretion rate is reduced by 18%-22%, the safety and compliance are excellent, and the composition is suitable for industrial production.

The invention discloses a high-content propolis ethanol extract soft capsule and a production process thereof. The contents comprise the following raw materials in parts by weight: 30-40 parts of a high-content propolis ethanol extract, 10-20 parts of nanoscale propolis particles, 55-65 parts of polyethylene glycol 600, 5-8 parts of optimized vegetable oil, 3-8 parts of glycerol, 1-3 parts of a suspending aid, 0.5-1.5 parts of vitamin E, 1-3 parts of nano silicon dioxide and 0.1-0.3 part of sodium citrate; and a capsule shell: 10-15 parts of gelatin, 2-5 parts of glycerol, 12-18 parts of purified water, 0.05-0.15 part of potassium sorbate and 0.1-0.3 part of titanium dioxide. The invention relates to the technical field of propolis products. According to the high-content propolis ethanol extract soft capsule and the production process, a pretreatment process of low-temperature freeze-drying, liquid nitrogen embrittlement and ultramicro wall breaking is adopted, so that propolis cell walls are thoroughly broken, and the specific surface area is greatly increased; in cooperation with a gradient ethanol extraction technology, high-polarity flavonoid and phenolic acid components are extracted by using high-concentration ethanol, and then moderate-polarity active components are extracted by using moderate-concentration ethanol, so that sufficient dissolution of the different-polarity active components is realized.