225 results about "Phenolic acid" patented technology

The invention discloses bacillus velezensis YB-1652, a biocontrol microbial inoculum and application of the biocontrol microbial inoculum, and aims to solve the technical problem of lack of effective biological control measures for continuous accumulation of peanut phenolic acid autotoxic substances and pathogens in continuous cropping. According to the application, a bacillus velezensis YB-1652 strain is separated and screened from rhizosphere soil of continuous cropping peanuts, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.36152. The strain has the capability of efficiently degrading phenolic acid compounds, relieves continuous cropping obstacles and improves the soil environment; the compound has a relatively strong inhibition effect on southern blight and root rot of peanuts, and the occurrence rate of soil-borne diseases is reduced; meanwhile, peanut growth can be promoted; the bacillus amyloliquefaciens has siderophore, cellulase, beta-glucanase, amylase power and protease production capacity. The YB-1652 strain and the preparation thereof can provide technical support for restoration of peanut continuous cropping obstacles, provide bacterial source guarantee for prevention and treatment of peanut soil-borne diseases, replace or reduce use of chemical pesticides and improve food and ecological environment safety, and have good economic and social benefits.

The invention relates to the technical field of cosmetic functional raw material preparation methods, in particular to a plant extract and an extraction method and application thereof. The invention provides a plant extraction method, which comprises the following steps: adding a glycol ether or polyhydric alcohol solvent containing 5-7 carbon atoms into a product containing phenolic acid compound components and lignan compound components, carrying out homogeneous reaction, carrying out heating extraction, and collecting the extract. By adopting a supramolecular technology, phenolic acid compound components can form a supramolecular solvent with glycol ether or polyol solvents containing 5-7 carbon atoms, and the supramolecular solvent is further combined with lignan compound components to form a supramolecular structure, so that the stability of an extracting solution is remarkably enhanced, the specific enrichment of the lignan compound components is realized, and the specific enrichment of the lignan compound components is realized. The problems that an existing extraction technology is poor in stability, poor in formula applicability, not prominent in effect and the like are successfully solved.

The present application relates to cannabidiol esters, compositions comprising them and their use in the treatment of a variety of different diseases, disorders and symptoms.

The invention discloses application of dikafen phenolic acid and ester derivatives thereof in preparation of medicines for treating pulmonary fibrosis. On an MRC-5 cell model induced by TGF-beta1, the bikafen phenolic acid and the multiple ester derivatives thereof show the activity of inhibiting alpha-SMA and COL1A1 protein expression; on a bleomycin-induced pulmonary fibrosis mouse model, the dimethyl ester derivative of the dikafen phenolic acid shows a good protective effect on experimental animals. Therefore, the dicafen phenolic acid and the ester derivative thereof have good application in the field of preparation of medicines for treating pulmonary fibrosis diseases.

The application discloses a method for simultaneously determining phenolic acid and tanshinone components in Danshen injection, and according to the structure and property characteristics of the phenolic acid and tanshinone components, the best mobile phase composition, elution program, flow rate, chromatographic column and mass spectrometry condition are screened through a large number of experiments. Experimental verification shows that the UPLC-TQ-MS / MS method can simultaneously determine 11 different structure and type of phenolic acid and tanshinone component compounds, and the methodological verification shows that the detection method has good precision, repeatability and high accuracy, and has important significance for controlling the quality of Danshen injection and guaranteeing the clinical curative effect.

A probiotic and prebiotic-embedded synbiotic system for targeted delivery and colonization of functions, comprising a probiotic core; an inner layer of protein-polysaccharide / oligosaccharide complex wrapped around the probiotic surface, which acts as both an adhesion promoter, promoting the attachment of probiotics to the intestinal epithelial cells, and as a prebiotic, promoting the growth of probiotics upon release; and an outer layer of a natural emulsifying system on the synbiotic complex, which minimizes water infiltration, thereby effectively embedding and protecting the probiotics. The present synbiotic system is suitable for production in powder form using freeze-drying technology, and is suitable as a dietary supplement or for addition to any food in dry powder form. The system has the ability to bioconvert soy isoflavones and release bioactive phenolic acids from grains to promote body health.

The invention relates to the technical field of forest cultivation, and discloses a carya illinoensis fruit forest variety configuration method which comprises the following steps: configuring a main cultivation variety and a pollination variety in a fruit forest; preparing a pollination synergistic composition; the composition is sprayed at the initial stage of stigma exposure of female flowers of a main cultivated variety. The composition comprises a phenolic acid grafted carboxymethyl chitosan derivative, low methoxyl pectin, a calcium ion cross-linking agent, sugar alcohol chelated boron and spermidine. According to the method, an interfacial film with antioxidant activity is formed on the surface of the stigma by using the grafting modified matrix, so that the stigma browning is effectively inhibited, and the pollination period is prolonged; by constructing a calcium cross-linked low-methoxyl pectin interpenetrating network, an interfacial film is endowed with an intelligent degradation characteristic of enzyme-sensitive response to pollen, and protection at ordinary times and immediate dissolution after touching flowers are realized. According to the method, pollen is captured through static electricity, nutritional factors are released in a targeted mode, the pollination and fertilization efficiency is remarkably improved, the sterility risk in the flowering phase is relieved, and the yield and quality of carya illinoensis are improved.

The invention provides a bacillus aerophilus Sys-Gs-010 strain capable of efficiently degrading benzoic acid in soil, the strain is preserved in the China Center for Type Culture Collection on December 10, 2025, the preservation number is CCTCC NO: M20252819, the preservation number is CCTCC NO: M20252819, the preservation number is CCTCC NO: M20252819, and the preservation number is CCTCC NO: M20252819. The 16S rDNA (ribosomal deoxyribonucleic acid) sequence of the strain is as shown in SEQ ID NO. 1. The bacillus aerosus Sys-Gs-010 strain provided by the invention can efficiently degrade ginseng to produce a main phenolic acid allelochemical-benzoic acid, and the strain is a non-ginseng pathogenic strain, can be applied to preparation of a ginseng allelochemical-benzoic acid degrading bacterial agent, greatly improves continuous cropping obstacles of ginseng, and has a good application prospect in the field of ginseng planting.

The application discloses a use of a pharmaceutical composition of a phenolic acid compound and probiotics, and particularly relates to a combination of chlorogenic acid and lactobacillus reuteri. The combination of chlorogenic acid and lactobacillus reuteri can improve glycolipid metabolic disorder, improve cognitive dysfunction, emotional disorder and delay aging, and can be used for preparing a medicine for treating metabolic disorder combined with neuropsychiatric diseases.

The invention relates to the technical field of biology, in particular to a tobacco Nt4CL9 gene and application thereof. According to the application, tobacco Nt4CL9 is knocked out, and compared with a wild type, the cold stress tolerance of the knocked-out mutant strain is improved, the content of flavonoid substance rutin is obviously increased, and phenolic acid substances are increased; potential support is provided for improvement of tobacco cold stress capacity and tobacco quality, and the method has important practical value in genetic improvement of tobacco important characters and basic research of botany.

The invention discloses application of cynarin in preparation of a medicine for resisting respiratory syncytial virus. The cynarin is polyphenolic acid cynarin, and the respiratory syncytial virus is an RSV-A2 strain; the compound can effectively inhibit replication of respiratory syncytial viruses, is a monomer component of natural medicinal plants, is clear in structure, stable in chemical property, easy in quality control and free of obvious toxic and side effects, can effectively resist inflammation while serving as an active component of a natural small-molecule antiviral drug, and has a broad application prospect. Viral lung inflammatory infiltration and lung injury caused by the respiratory syncytial virus are relieved.

The invention provides a method for simultaneously detecting various phenolic acids and flavonoid active substances in perilla frutescens, which is characterized in that perilla leaves, stems and seeds are taken as detection objects, an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS) technology is adopted, a mixed reference substance solution and a to-be-detected sample solution are prepared, chromatography-mass spectrometry detection parameters are optimized, and the content of various phenolic acids and flavonoid active substances in the perilla frutescens is determined. 15 active substances can be accurately quantified at the same time; the method has the advantages that the pretreatment is simple and convenient, the analysis time is only 10 minutes, the detection sensitivity is high, the detection limit is as low as 0.002 g / L, the linear relation is good, R2 is greater than or equal to 0.9987, the precision, the accuracy and the stability all meet the detection standard, and the detection range covers 1-5000 g / L. The method provides reliable technical support for quality evaluation, product control and standardized production of perilla frutescens, is suitable for detection of perilla frutescens related products, and promotes industrial development of medicinal and edible substances.

The present application belongs to the technical field of biological medicine, and particularly relates to a pharmaceutical composition for treating pulmonary fibrosis and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 12-18 parts of Astragalus membranaceus, 6-12 parts of Ophiopogon japonicus, 4-10 parts of Poria cocos, 1-3 parts of Radix Glycyrrhizae, 10-16 parts of Salvia miltiorrhiza, 6-12 parts of Scutellaria baicalensis, 4-10 parts of Morus alba, 2-6 parts of Pericarpium Citri Reticulatae Viride, 1-4 parts of Sophora flavescens and 1-4 parts of Fritillaria cirrhosa. The present application is a three-phase and fixed-ratio compound of polysaccharides, phenolic acids and flavonoids. The polysaccharides are obtained by water extraction and alcohol precipitation, and are used as a mucosal retention adhesion carrier. The phenolic acids and flavonoids are extracted by low-degree ethanol refluxing, so as to ensure the structural integrity and maintain stability. The alkaloids are extracted by ethanol and then mildly salified, so as to reduce irritation and adsorption loss. The polysaccharides are then subjected to selective light fermentation to build a slightly acidic environment. In the compounding process, a buffer system is used to adjust pH, and cyclodextrin is used to stably bind the components. The three phases synergistically intervene in oxidation-inflammation-fibrosis.

This invention provides a phenolic acid-modified attapulgite composite sunscreen agent, its preparation method, and applications, as well as a Pickering sunscreen lotion, belonging to the field of cosmetic technology. The method of this invention includes acid treatment of attapulgite, surfactant modification, loading of phenolic acid biomolecules, and hydrophobic modification. Using modified attapulgite as a carrier, this invention loads phenolic acid biomolecules through electrostatic adsorption to construct a composite synergistic system, and further modifies the surface with hydrophobicity to obtain a composite sunscreen agent with high stability and excellent sun protection performance. The sunscreen agent prepared by this invention combines physical shielding and biological protection functions, exhibiting excellent UV absorption capacity, good dispersibility, skin compatibility, and a pleasant feel on the skin. It solves the problems of nanoparticle aggregation, whitening, and poor photostability in existing sunscreen products, making it suitable for the cosmetic sunscreen field. It can achieve broad-spectrum UVA / UVB protection, antioxidant properties, and soothing repair, showing broad application prospects.

The invention relates to the technical field of medicines for treating intestinal ischemia-reperfusion injury, and discloses a medicine for treating intestinal ischemia-reperfusion injury and a preparation method thereof. Comprising 10 to 25 parts of rosmarinic acid, 5 to 15 parts of betaine, 3 to 10 parts of glutamine, 10 to 25 parts of salvianolic acid B, 5 to 15 parts of astragaloside, 3 to 10 parts of ginsenoside Rg1, 2 to 8 parts of curcumin, 5 to 12 parts of ophiopogon japonicus polysaccharide, 2 to 6 parts of notoginsenoside R1, 3 to 7 parts of total flavonoids of oldenlandia diffusa and 4 to 9 parts of angelica sinensis polysaccharide. The medicine disclosed by the invention can be used for relieving intestinal edema, repairing oxidative injury, clearing excessive ROS, improving SOD activity, blocking oxidative stress injury, inhibiting epithelial cell apoptosis, reducing intestinal permeability and maintaining mucous membrane integrity, and has an excellent treatment effect on intestinal ischemia reperfusion injury.

The invention discloses application of rice bran in preparation of food or health care products with functions of relaxing bowels and promoting intestinal peristalsis, and relates to the field of functional food. According to the application, the combination of active components of unsaturated fatty acid-phenolic acid-amino acid derivatives in the rice bran is defined through systematic component analysis, richer material basis explanation is provided for the bowel relaxing effect of the rice bran, the effective concentration range and the optimal concentration of the rice bran are quantified, and a direct experimental basis is provided for product dosage design.

The application provides a method for establishing HPLC fingerprint of Changnyle capsule (I), which is characterized in that 16 active components including gastrodin, danshensu, quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiopicroside, 3'-hydroxy puerarin, puerarin, 3'-methoxy puerarin, puerarin apioside, paeoniflorin, daidzin, rosmarinic acid, shikonin, isoquercitrin, ononin, daidzein, salvianolic acid B and calycosin are used as reference substances, HPLC is adopted, methanol-acetonitrile-0.5vol% phosphoric acid aqueous solution is used as a mobile phase, different batches of samples are detected, and finally the fingerprint of Changnyle capsule (I) is obtained. The fingerprint can comprehensively represent the main components in Changnyle capsule (I), thereby being beneficial to the quality control of Changnyle capsule (I).

The invention relates to a high-strength antibacterial spandex fabric and a preparation method thereof, and belongs to the technical field of functional textile materials. The spandex fiber comprises a spandex fiber matrix and a functional polymer layer grafted on the surface of the matrix through a covalent bond, and the functional polymer layer is a polymer of an unsaturated derivative of natural phenolic acid and is prepared by introducing carbon-carbon unsaturated bond groups such as acryloyloxy and the like into the natural phenolic acid through esterification or etherification. During preparation, the spandex fiber is subjected to plasma pretreatment, and then the spandex fiber and the natural phenolic acid-containing unsaturated derivative monomer are subjected to thermal initiation or photo-initiation graft polymerization to form the functional layer. The lasting and stable antibacterial function is achieved through covalent bond grafting, the natural phenolic acid derivative endows the fiber with the environment-friendly and non-dissolution type antibacterial property, the functional layer can improve the modulus and breaking strength of the fiber, the intrinsic elasticity of spandex is considered, the comfortable fitting characteristic of the composite fabric is reserved, and the composite fabric is endowed with the high strength and the antibacterial function.

This invention provides a magnetic manganese-based lithium-ion sieve, its preparation method, and its applications. The magnetic manganese-based lithium-ion sieve includes a magnetic core, and an intermediate carbon layer and an active layer of manganese-based lithium-ion sieve material sequentially coated around the magnetic core. The carbon layer, as the intermediate layer, effectively prevents lithium elements from contacting the magnetic core, thereby reducing the formation of by-products. It also helps to improve the coating effect of the active layer and increase its coating thickness. The preparation method involves coating the active layer with phenolic resin and then carbonizing it at high temperature to form the carbon layer. During this process, the escape of pyrolysis gases results in a mesoporous structure in the active layer, and the high temperature helps to optimize the crystal structure of the spinel lithium manganese oxide material. The resulting magnetic manganese-based lithium-ion sieve exhibits excellent adsorption capacity, stability, and service life.

The invention belongs to the technical field of microorganisms, and provides a high-yield feruloyl esterase plant lactobacillus and application thereof. The bacterial strain is lactobacillus plantarum Fs6, the preservation number of the bacterial strain is CGMCC (China General Microbiological Culture Collection Center) No.36264, and the preservation date of the bacterial strain is October 20, 2025. According to the present invention, the fermentation performance of the dough can be significantly improved with the plant lactobacillus, and the good synergistic effect is represented during the co-fermentation with the yeast; and a good synergistic effect is shown during co-fermentation with yeast. When the mass concentration of bile salt is 0.3 and 0.6 g / L, the survival rate is relatively good, which shows that the lactic acid bacteria Fs6 has a certain probiotic function. The self-aggregation force (32.77%) and the hydrophobicity (32.43%) of the Fs6 are relatively low, and the adhesion of the Fs6 is relatively poor. And combined phenolic acid in the grains can be effectively released, so that the nutritional value of the grains can play a better health role in a human body.

The present application belongs to the field of biopharmacy, and particularly relates to a phenolic acid composition and application thereof in promoting digestion. The present application firstly finds a single phenolic acid for improving dyspepsia through single-component phenolic acid experiments, then attempts to find a phenolic acid compound with a synergistic effect through compounding, and surprisingly, the combination of two phenolic acids with the best effect on promoting digestion cannot achieve the best effect optimization, but eugenol with the worst effect on promoting digestion achieves a synergistic effect on promoting digestion through compounding with other phenolic acids, and can achieve the effect of a positive drug, which provides a potential alternative drug for improving dyspepsia.

Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((−)-trans-Δ9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.

Provided are the screening and identification of a Pseudomonas sp. strain for producing feruloyl esterase at high yield and a use of the Pseudomonas sp. strain as a bioaugmentation agent in fermented foods, relating to the technical field of brewing. By means of screening, a Pseudomonas sp. strain A-4H for producing feruloyl esterase at high yield is obtained. After cultivation for 36 h, the Pseudomonas sp. strain A-4H can produce ferulic acid at a concentration of 153.79±2.36 mg / L, and the activity of feruloyl esterase in a fermentation broth reaches 136.63±10.27 U / L. The addition of the Pseudomonas sp. A-4H during the brewing of Huangjiu can effectively increase the content of ferulic acid, the content of phenolic acid, and the content of organic acid in Huangjiu, providing an effective biological pathway for increasing the content of ferulic acid in fermented foods.

The present disclosure features compositions and methods for producing one or more cannabinoids, such as cannabidiolic acid (CBDa) or cannabidiol (CBD), in a host cell, such as a yeast cell, that is genetically modified to express the enzymes of a cannabinoid biosynthetic pathway. Using the compositions and methods of the present invention, the host cell may be genetically modified to express one or more enzymes of a cannabinoid biosynthetic pathway, such as CBDaS. The host cell may be cultured in the medium in the presence of a first cannabinoid, for example CBGa, and incubated for a time sufficient to allow for bioconversion of the first cannabinoid to a second cannabinoid, for example CBDa, by the host cell.

A method and formulation for improvement in at least the texture and shelf stability of starch-based foods is disclosed, such as but not limited to gummy candies, through the incorporation of polyphenols, wherein said polyphenols may include but are not limited to one or more of flavonoids, phenolic acids, lignans, stilbenes, and tannins. This method and formulation comprises the use of polyphenol molecules to improve and stabilize starch-based foods for extended periods of time without the use of artificial preservatives. The method and formulation including one or more polyphenols also allows utilization of specific beneficial qualities of the polyphenols including: flavor, aroma, color and the numerous associated health benefits. Thus, the method and formulation facilitates the production of various starch-based foods (e.g., chewy candies, mochi, breads, cakes, pastas, etc.) with unique and previously unattainable qualities that are advantageous for consumer-packaged foods.

The invention belongs to the technical field of medicines, and particularly relates to a tanshinone and salvianolic acid compound molecular compatibility composition for regulating and controlling the balance relation of DNMTs / TET2 and application of the tanshinone and salvianolic acid compound molecular compatibility composition. An in-vitro cell model proves that the composition with specific compatibility can synergistically regulate the expression of DNMTs and TET2 and recover the balance relation of DNMTs and TET2, so that the abnormal DNA methylation state is reversed, the normal expression of related genes is recovered, and the composition can be used for preparing the medicine for preventing or treating cardiovascular diseases related to DNA methylation abnormity. The molecular compatibility composition for balance regulation and control of key targets is created for the first time, has the advantages of clear component compatibility, clear action targets and synergistic interaction, and provides a new choice for developing novel epigenetic regulation and control drugs.

The invention discloses a high-content propolis ethanol extract soft capsule and a production process thereof. The contents comprise the following raw materials in parts by weight: 30-40 parts of a high-content propolis ethanol extract, 10-20 parts of nanoscale propolis particles, 55-65 parts of polyethylene glycol 600, 5-8 parts of optimized vegetable oil, 3-8 parts of glycerol, 1-3 parts of a suspending aid, 0.5-1.5 parts of vitamin E, 1-3 parts of nano silicon dioxide and 0.1-0.3 part of sodium citrate; and a capsule shell: 10-15 parts of gelatin, 2-5 parts of glycerol, 12-18 parts of purified water, 0.05-0.15 part of potassium sorbate and 0.1-0.3 part of titanium dioxide. The invention relates to the technical field of propolis products. According to the high-content propolis ethanol extract soft capsule and the production process, a pretreatment process of low-temperature freeze-drying, liquid nitrogen embrittlement and ultramicro wall breaking is adopted, so that propolis cell walls are thoroughly broken, and the specific surface area is greatly increased; in cooperation with a gradient ethanol extraction technology, high-polarity flavonoid and phenolic acid components are extracted by using high-concentration ethanol, and then moderate-polarity active components are extracted by using moderate-concentration ethanol, so that sufficient dissolution of the different-polarity active components is realized.

Disclosed in the present invention are a simple phenolic acid derivative- and rosmarinic acid derivative-based multimodal imaging probe and a use thereof. The multimodal imaging probe of the present invention has a structure selected from those represented by formulas (I to III). By subjecting phenolic acids such as danshensu, caffeic acid, ferulic acid, and rosmarinic acid to derivatization modification and by means of molecular imaging technology, the present invention realizes in vivo tracing and imaging of diseases such as various tumors (liver cancer, pancreatic cancer, and breast cancer), stroke, myocardial infarction, and acute kidney injury, and achieves in vivo and in vitro high-contrast imaging, real-time monitoring, and qualitative and quantitative evaluation. Moreover, the probe of the present invention itself has good metabolic properties and targeting performance, is simple to prepare and low in cost, and has broad clinical application prospects.

Provided is a pharmaceutical composition and application thereof, specifically, said pharmaceutical composition comprises: salvianolic acid B as a first active ingredient; and ginsenoside Rg1 as a second active ingredient, and the weight ratio of the first active ingredient to the second active ingredient being 5:(1-4.5). The pharmaceutical composition has a better active-ingredient proportion than the prior art, has a better therapeutic efficacy in preventing and / or treating ischemic diseases, and ischemia-reperfusion tissue or organ damage, and can be used for treating ischemia and / or ischemia-reperfusion damage of different tissues and organs.

The invention relates to an anthocyanin nano system for promoting cell transport and absorption and a preparation method and application thereof, and belongs to the technical field of nano delivery carrier design and functional active ingredient absorption and utilization. The preparation method of the anthocyanin nano-system for promoting cell transport and absorption comprises the following steps: under a stirring condition, dropwise adding an anthocyanin solution into a phenolic acid modified zein solution, fully combining, adding a sulfhydrylated hyaluronic acid solution, stirring, carrying out ultrasonic treatment, and carrying out an anti-solvent precipitation method to obtain the anthocyanin nano-system. The nano delivery system which can actively recognize and utilize the anthocyanin forward transporter SGLT1 / GLUT2 and inhibit P-gp efflux is constructed, the gastrointestinal tract stability of the anthocyanin is improved, the uptake rate and bioavailability of small intestine epithelial cells are improved from the mechanism, and the nano delivery system has safety and applicability and is suitable for industrial production. The method is suitable for being popularized in the field of functional food ingredients or drug delivery, and has remarkable innovativeness and application value.