17 results about "Chicoric acid" patented technology

The invention belongs to the field of biological medicine, and discloses a chicoric acid (CA)-loaded tetrahedral framework nucleic acid (tFNA) nano preparation for treating acute gouty arthritis. According to the preparation, tFNA formed by self-assembly is taken as a carrier, and a natural active ingredient CA is loaded to form a CA-tFNA compound. The compound overcomes the defects that CA is poor in water solubility and low in bioavailability, and existing drugs are weak in targeting and large in side effect. Through the targeted delivery and synergistic effect of tFNA, the preparation can be effectively enriched in inflammatory joints, significantly inhibit NF-kappa B signal pathways, and down-regulate the expression of key proinflammatory factors such as TNF-alpha and IL-1beta, so that joint swelling and synovial tissue damage are relieved, and repair is promoted. Experiments show that the traditional Chinese medicine composition is remarkable in curative effect and good in safety, and a novel efficient treatment strategy is provided for acute gouty arthritis.

The application discloses a dandelion medicinal material effective component rapid determination method based on color chroma values, and relates to the technical field of traditional Chinese medicinal material quality detection. * , a * , b * Chroma values of dandelion medicinal material powder are collected, and the contents of chicoric acid, monocaffeoyl tartaric acid and chlorogenic acid are determined by using high performance liquid chromatography as true values; subsequently, a neural network prediction model with chroma values as input and effective component contents as output is constructed and trained, preferably a single hidden layer structure; finally, the model is used for fast and nondestructive content prediction of unknown samples; compared with a traditional multiple linear regression model, the neural network model used in the application has significantly higher prediction accuracy, and the test set R² is all more than 0.86; the application realizes fast, nondestructive, low-cost and high-precision detection of dandelion medicinal material effective components, and is suitable for multiple scenes such as raw material quality control, market supervision, optimal harvest period judgment and fast pricing grading.

The invention discloses a chicoric acid carrier with a DNA regular tetrahedron as a skeleton and a preparation method of the chicoric acid carrier. According to the method, four oligonucleotide chains with specific sequences are synthesized, so that the oligonucleotide chains are self-assembled in a buffer solution to form a stable DNA regular tetrahedral structure. And then loading the natural active component chicoric acid with poor water solubility and low chemical stability into the interior or on the surface of the tetrahedron in a physical embedding or electrostatic adsorption manner. The obtained compound utilizes a hydrophilic skeleton of a DNA tetrahedron, so that the water solubility and chemical stability of the chicoric acid are remarkably improved, and the degradation rate of the chicoric acid under light, heat and oxidation conditions is effectively reduced. The problem that the clinical application of the chicoric acid is limited due to poor physicochemical properties, fast in-vivo metabolism and difficult targeted delivery is solved, and a new strategy is provided for further development of the chicoric acid.

According to the application of the implant-derived exosome as the carrier in preparation of the medicine for targeted therapy of colitis, chicoric acid is loaded in the purple rice exosome, so that the defects that chicoric acid is low in oral bioavailability and poor in gastrointestinal tract stability are overcome, colon targeting and accumulation of the medicine are achieved, and the curative effect of the medicine is improved. An ideal functional carrier and a candidate preparation are provided for developing a novel anti-colitis nano-drug with high efficiency and low toxicity, and an innovative path is opened up for deep processing and industrial chain extension of purple rice resources in Yunnan province.

Provided herein are polyphenol-enriched lettuce powders comprising particles of a polyphenol-enriched lettuce or extract, wherein the polyphenol-enriched lettuce comprises from 40-280 mg / g of polyphenols. The polyphenols include any combination of a chlorogenic acid, a neochlorogenic acid, a chicoric acid, a quercetin, a quercetin derivative, and an anthocyanin. The disclosure also provides compositions and methods of using the polyphenol-enriched lettuce powders to promote wound healing and treat inflammation and skin disorders.

The invention discloses a multi-index content determination method of hovenia acerba and rhizoma atractylodis bowel-relaxing granules, and belongs to the technical field of traditional Chinese medicine detection. The invention establishes a high performance liquid chromatography method for simultaneously determining nine components including caffeic acid, chicoric acid, naringin, naringin, hesperidin, neohesperidin, chrysophanol, aurantio-obtusin and atractylenolide I in a preparation, and the content of the components is calculated through a relative correction factor by taking caffeic acid as an internal reference by adopting a quantitative analysis of multi-components by single marker. According to the method, effective detection of the immature bitter orange medicinal material and the immature bitter orange base source is realized, and the immature bitter orange and the sweet orange base source of the traditional Chinese medicine immature bitter orange can be accurately distinguished, so that more comprehensive and accurate quality control of the traditional Chinese medicine is realized, and the stability and consistency of clinical efficacy of the traditional Chinese medicine are guaranteed.

This invention relates to the field of mosquito repellent composition technology, specifically to a plant-based mosquito repellent composition and its preparation method, comprising Sophora flavescens extract, eucalyptol, montmorillonite glycol, and natural Echinacea purpurea extract; the natural Echinacea purpurea extract is an aqueous extract with a chicoric acid content ≥4%. The plant-based mosquito repellent composition and preparation method of this invention, through functional optimization of single components and synergistic formulation of multiple components, fundamentally solves the core problems of existing plant-based mosquito repellent products, such as poor mosquito repellent effect, short effective duration, and lack of skin soothing function, while also taking into account the product's naturalness and safety. Because a combined low-temperature enzymatic hydrolysis-stepwise alcohol extraction-microfiltration purification process is used to prepare the Sophora flavescens extract, and natural menthol extract is added as a drug guide, the extraction rate and utilization efficiency of plant active ingredients are effectively improved, reducing the waste of plant resources. Furthermore, the preparation process is green and environmentally friendly, generating no harmful waste.

To provide a permanent wave pretreatment agent, a permanent wave solution, and a permanent wave method that offer excellent wave retention in permanent waves. [Solution] The permanent wave pretreatment agent contains one or more polyphenols selected from chicoric acid, gallic acid, tannic acid, tyriloside, and echinacoside; the permanent wave agent contains one or more polyphenols selected from chicoric acid, gallic acid, tyriloside, echinacoside, and quercetin, and a reducing agent; and the permanent wave method uses the above permanent wave pretreatment agent and / or permanent wave agent.

The present application relates to the use of chicoric acid in the preparation of a medicament for preventing and / or treating myasthenia gravis. Specifically, the present application provides the use of chicoric acid and pharmaceutically acceptable salts, esters, solvates, polymorphs or prodrugs thereof in the preparation of a medicament for preventing and / or treating myasthenia gravis. The present application focuses on the use of the compound chicoric acid in correcting the core immune imbalance of myasthenia gravis, Th17 / Treg cell balance, intervening from the upstream of the disease, and is expected to achieve the fundamental treatment of myasthenia gravis and more persistent efficacy.

The invention relates to medical cold compress gel for improving gout and a preparation method of the medical cold compress gel. The medical cold compress gel comprises the following components in percentage by weight: (1) a cooling matrix material: 0.5-2% of carbomer, 5-15% of glycerol and 3-8% of propylene glycol; (2) natural anti-inflammatory components: 1-3% of a radix scutellariae extract and 0.5-1.5% of asiaticoside; (3) a uric acid inhibitor: 0.2%-1% of apigenin nano-liposome and 0.1%-0.5% of chicoric acid; (4) a transdermal penetration enhancer: 1-3% of azone and 0.5-2% of menthol; and the balance of deionized water. The invention has the following beneficial effects: 1, physical-chemical synergistic effect: red and swollen can be relieved by cold compress, and inflammatory factors such as IL-1beta, TNF-alpha and the like can be inhibited by the active components; 2, targeted inhibition of uric acid: apigenin nano-liposome enhances transdermal absorption and inhibits the activity of xanthine oxidase; 3, the safety is high: the systematic side effects of the traditional medicine are reduced by the natural components;

The invention discloses application of chicoric acid in preparation of a medicine for improving hematopoietic injury caused by radiation, and belongs to the technical field of biological medicine. In order to solve the problem that an effective intervention means for hematopoietic system injury caused by ionizing radiation is lacked in the prior art, the invention provides application of chicoric acid in preparation of drugs for improving hematopoietic injury caused by radiation, and shows a dual protection mechanism of chicoric acid acting on a hematopoietic differentiation key regulation node. The hematopoietic function is synergistically improved by regulating EPO and other hematopoietic factors and progenitor cell populations, meanwhile, the anti-oxidation effect is achieved, radiation damage is relieved, definite active ingredients and action targets are provided for preparing the medicine for preventing and treating hematopoietic damage caused by radiation, and the application value of clinical transformation is achieved.

This invention relates to the field of natural product extracts and mitochondrial quality control regulation technology, and provides a mitochondrial quality control regulation extract composition derived from red lettuce and its uses. The composition contains active ingredients such as chlorogenic acid, chicoric acid, quercetin glycosides, and anthocyanins, and possesses a stable HPLC fingerprint. Experimental results show that the composition can significantly restore ATP levels in cells damaged by oxidative stress, improve mitochondrial membrane potential and respiratory function, activate AMPK-related pathways, inhibit downstream mTORC1 signaling, enhance mitophagy, and promote mitochondrial regeneration, thereby achieving synergistic regulation of the mitochondrial quality control system. The composition has the advantages of well-defined composition, batch stability, and overall superior effects compared to artificial mixtures, making it suitable for preparing products that regulate mitochondrial function.

The invention discloses a preparation method of chicken small intestine epithelial cell apoptosis vesicles. The preparation method comprises the following steps: culturing chicken small intestine epithelial cells; inducing cell apoptosis; and preparing the apoptosis vesicles. The invention also discloses the chicken small intestine epithelial cell apoptosis vesicle prepared by the method and application thereof. The chicken small intestine epithelial cell apoptosis vesicle can load chicoric acid, and has the effects of resisting inflammation, enhancing cell oxidation resistance and promoting chicken small intestine epithelial cell proliferation and cell migration.

The invention relates to the technical field of medicines, in particular to application of a bufalin composition in preparation of a medicine for treating lung cancer. The bufalin composition comprises bufalin and a chicoric acid derivative, the molar ratio of the bufalin to the chicoric acid derivative is 1: (0.1-0.3). Experimental results show that the anti-tumor effect can be remarkably enhanced through the synergistic effect of the bufalin and the chicoric acid derivative, and the chicoric acid derivative can also achieve the dual optimization purposes of solubilization and toxicity reduction at the same time.

The invention discloses a quality transmission quality control method in the whole process of preparing a milk nuclear drink. Comprising the following steps: collecting a milk nuclear drink concentrated solution, a centrifugate and a decoction sample; determining seven physical parameters including pH, refractive index, dynamic viscosity, conductivity, total amount of soluble solids, solid content and density of the sample, and constructing a physical fingerprint spectrum; the method comprises the following steps: determining the contents of seven index components including gallic acid, chlorogenic acid, loganin, paeoniflorin, ferulic acid, chicoric acid and icariin by adopting an HPLC (High Performance Liquid Chromatography) method, calculating the transfer rate of the seven index components in each process stage, establishing a chemical fingerprint spectrum, identifying common peaks and calculating the similarity; and analyzing the correlation between the physical parameters and the index components through a heat map. The multi-index evaluation mode of physical fingerprint spectrum-chemical fingerprint spectrum-multi-component content determination constructed by the invention can systematically evaluate the influence of the traditional Chinese medicine preparation process on the overall quality, and provides a scientific basis for quality control in the traditional Chinese medicine production process.

The invention discloses a dandelion TmbHLH93 gene as well as an expression protein and application thereof, and belongs to the technical field of plant genetic engineering. The nucleotide sequence of the TmbHLH93 gene is as shown in SEQ ID NO. 1, and the amino acid sequence of the encoded protein of the TmbHLH93 gene is as shown in SEQ ID NO. 2. The TmbHLH93 gene is cloned from dandelion, a plant overexpression vector of the TmbHLH93 gene is constructed, the dandelion is transformed, and a transgenic plant is obtained. Experiments show that overexpression of the TmbHLH93 gene can significantly up-regulate expression of key enzyme genes related to a chicoric acid synthetic pathway, and increase accumulation of chicoric acid in transgenic plant leaves. The invention provides a key gene and a technical basis for cultivating a new dandelion variety with high chicoric acid content through transcription factor engineering.

The present application discloses Taraxacum mongolicum TmHY5 gene, expression protein and application thereof, and belongs to the technical field of plant molecular biology.The nucleotide sequence of the Taraxacum mongolicum TmHY5 gene disclosed by the present application is shown as SEQ ID NO.1.The present application takes Taraxacum mongolicum leaves as materials, obtains the Taraxacum mongolicum TmHY5 gene through cloning, constructs an overexpression vector pRI101-TmHY5-GFP on the basis, and is transferred into Taraxacum mongolicum to obtain transgenic plants.The chicoric acid content analysis result shows that the chicoric acid content of the transgenic Taraxacum mongolicum is significantly higher than that of the control group;the gene function identification result shows that the TmHY5 gene activates the expression of the Tm4CL1 gene in Taraxacum mongolicum to increase the chicoric acid content.The TmHY5 gene is an important gene for Taraxacum mongolicum to carry out genetic engineering and improved breeding.