35 results about "Therapy radiation" patented technology

Disclosed herein are methods for radiotherapy treatment planning and delivery that use sensor data from one or more target sensors. One variation of a radiotherapy treatment planning method comprises generating a sensor characterization image based on a sensor characterization probability density function (PDF) of a target sensor and calculating a set of firing filters that may be applied to sensor images generated from sensor data acquired during a radiation-delivery session. Additionally, a variation of a radiotherapy treatment planning method comprises generating multiple sensor characterization images based on multiple sensor characterization PDF of multiple target sensors and calculating multiple sets of firing filters for each of the multiple target sensors. The firing filters may be used with sensor images generated from target sensor data acquired from one or more target sensors during a radiation-delivery session to calculate a radiation fluence for delivering therapeutic radiation to a target region.

Disclosed herein are methods for verifying whether a radiotherapy delivery system delivers therapeutic radiation to a target region in accordance with instructions from a radiotherapy system controller. The method utilizes imaging data acquired by a radiation imager (e.g., an MV detector) located opposite (e.g., positioned relative to) a therapeutic radiation source. In some variations, the imaging data from the radiation imager is used to determine whether a component of a radiation beam shaping assembly is in a position specified by the controller instructions. Also disclosed herein are methods for verifying whether a radiation beam emitted by the therapeutic radiation source intersects a target region and / or a contour around the target region, including methods for determining a delivery fluence and a dose estimate.

Apparatus and methods are described for treating an occlusion in a blood vessel. A catheter is inserted into the blood vessel. An irradiation unit is driven to emit probing radiation such that the probing radiation is directed toward the occlusion, and returning radiation which is returned in response to the probing radiation impacting the occlusion, is detected. A composition of at least a portion of the occlusion is derived based on a signature that is indicative of the composition within the returning radiation. The irradiation unit is driven to irradiate the portion of the occlusion by emitting treatment radiation having a set of irradiation parameters. The set of irradiation parameters is determined to modulate between a photoacoustic effect of the treatment radiation and a photothermal effect of the treatment radiation, based on the composition of the portion of the occlusion. Other applications are also described.

A therapeutic apparatus may be provided. The therapeutic apparatus may include a radiation therapy device configured to apply therapeutic radiation to a region of interest (ROI). The radiation therapy device may include an accelerator configured to accelerate electrons in an electron beam to produce a radiation beam of the therapeutic radiation, a magnetic resonance imaging (MRI) device configured to acquire MRI data with respect to the ROI. The MRI device may include an annular cryostat including at least one annular structure enclosing one or more chambers.

A radiotherapy treatment apparatus for imaging and treating a patient, comprising: a radiotherapy system comprising a treatment radiation source configured to perform radiotherapy treatment of a patient by directing treatment radiation towards the patient, wherein the patient is located substantially within a treatment region defining a longitudinal axis, wherein the treatment radiation source is moveable with respect to the longitudinal axis to thereby enable a selection of a treatment direction in preparation for radiotherapy treatment of the patient; an imaging system comprising an imaging radiation source and a radiation detector, wherein the imaging radiation source is moveable with respect to the longitudinal axis and is arranged to direct imaging radiation towards the patient in an imaging direction, and wherein the radiation detector is arranged to measure the imaging radiation after interaction of the imaging radiation with the patient, wherein the radiation detector comprises one or more photon counting detector arrays defining a sensitive area of the radiation detector, and wherein the imaging system is configured to generate multi-spectral images of the patient based on measurements of the imaging radiation by the one or more photon counting detector arrays.

The application discloses a kind of compositions for treating radiation enteropathy and application thereof, belong to medical technology field.The composition includes the following components: anemarrhena asphodeloides B4, obakunine, berberine, aesculetin, fraxinellone and fraxinellin.The composition has no toxic side effects, has good safety, can reduce the inflammatory infiltration of intestinal epithelial cells, reduce intestinal epithelial cell apoptosis, protect intestinal barrier and protect intestinal oxidative damage by regulating NF-κB, Caspase 9 / 3 and NRF2 pathway, and then multi-component, multi-pathway jointly play the efficacy of treating radiation enteropathy.The problem that there is no effective drug for treating radiation enteropathy in the prior art is solved.

The present invention relates to parenteral pharmaceutical compositions of suitable Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, particularly to Desidustat or suitable pharmaceutically acceptable salts thereof. The invention also relates to processes for preparing such compositions. The present invention also relates to the development of therapeutic compound for the treatment of radiation induced toxicity. Specifically, present invention relates to use of Desidustat or its pharmaceutically acceptable salt or oral and parenteral pharmaceutical composition thereof for the treatment of radiation induced toxicity.

The invention relates to the technical field of ion beam irradiation treatment radiation protection, and provides a treatment room radiation shielding system and method based on a rotating beam line, and the system comprises a central equipment room which is internally provided with rotatable treatment equipment; the plurality of treatment rooms are arranged around the central equipment room, and each treatment room is used for treating a patient; the radiation shielding wall body comprises a shielding partition wall and a shielding enclosure wall, the shielding partition wall is arranged between the adjacent treatment rooms, and the shielding enclosure wall is arranged on the periphery of the treatment rooms; a radiation attenuation channel communicated with the treatment room is defined by the shielding partition wall and the shielding enclosing wall. According to the treatment room radiation shielding system based on the rotating beam wire, the radiation attenuation channel communicated with the treatment room is defined by the shielding partition wall and the shielding enclosing wall, the space utilization rate is improved, and the limited space radiation shielding problem of the treatment room is solved.

The invention discloses a product for treating radiation damage. According to the application, GP532 is subjected to random mutation, a phage mutation library is established, and the mutation library is activated and screened by using TLR5-dependent NF-kappa B, so that 9E1 is obtained. 9E1 shows dose-dependent stimulation of TLR5 dependent NF-kB activation in vitro; an effective prevention effect is shown in an in-vivo mouse radiation injury model, and a new way is provided for effective treatment of radiation injury.

The present invention relates to parenteral pharmaceutical compositions of suitable Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, particularly to Desidustat or suitable pharmaceutically acceptable salts thereof. The invention also relates to processes for preparing such compositions. The present invention also relates to the development of therapeutic compound for the treatment of radiation induced toxicity. Specifically, present invention relates to use of Desidustat or its pharmaceutically acceptable salt or oral and parenteral pharmaceutical composition thereof for the treatment of radiation induced toxicity.

The present disclosure relates to an imageable microsphere comprising one or more radionuclides, and methods of making and using the same in transarterial radioembolization (TARE). The microsphere is a theranostic. The microsphere provides radionuclide imaging and emits therapeutic radiation.

The application discloses a kind of for radiation intestinal injury treatment composition and its application, it is related to medical technical field.The composition includes the following components: aesculetin, fraxinol, fraxin and baicalein.The composition of the application can reduce intestinal villus injury by regulating the NF-κB pathway and Caspase-9 / 3 pathway of intestinal epithelial cells, reduce the infiltration of intestinal inflammatory cells, reduce intestinal cell apoptosis, to relieve intestinal injury, and then multi-component, multi-pathway jointly play the efficacy of treating radiation intestinal injury.The application solves the problem that there is no effective drug for treating radiation intestinal injury in the prior art.

The application discloses a composition for treating radiation enteropathy and application thereof, and belongs to the technical field of biological medicine, and solves the problem that there is no effective treatment drug for radiation enteropathy at present. The composition comprises puerarin, baicalein, berberine and glycyrrhetinic acid. The composition for treating radiation enteropathy can regulate Wnt / beta-catenin, NF-kappa B and Caspase-9 / 3 signal pathways and the like, promote the proliferation of intestinal cells after radiation damage, reduce the inflammation level of intestinal tissues after radiation, reduce the apoptosis of intestinal cells after radiation and the like, improve the radiation damage of intestinal epithelial cells, play an anti-radiation enteropathy role, and has a remarkable effect on treating radiation enteropathy.

The invention discloses a human placenta-derived endothelial progenitor cell and a combined drug thereof as well as application of the human placenta-derived endothelial progenitor cell in preparation of a drug for treating radiation-induced thymus injury, and discloses a novel cell treatment drug for reconstructing a thymus microenvironment, recovering T cell generation and promoting thymus function repair and immune reconstruction aiming at thymus radiation injury. The placenta-derived endothelial progenitor cells are found to have an excellent effect of treating the radiation thymus injury, and the human placenta-derived endothelial progenitor cells and the human umbilical cord mesenchymal stem cells are synergistically combined to have a synergistic effect on treating the radiation thymus injury.

The present invention relates to a method and apparatus for multi-criteria optimization of radiation therapy plans. A control circuit accesses an optimized radiation therapy plan developed using corresponding utility functions corresponding to a plurality of metrics, and generates an approximation of the corresponding utility functions. The control circuit repeatedly selectively perturbs the approximation only with respect to a different subset of the plurality of metrics each time to generate a corresponding plurality of perturbed utility functions, and generates a plurality of supplemental optimized radiation therapy plans each time from a corresponding different one of the plurality of perturbed utility functions. The control circuit then employs the plurality of supplemental optimized radiation therapy plans and the optimized radiation therapy plan as a multi-criteria optimization workspace for a user to explore in selecting a particular optimized radiation therapy plan for employment in administering therapeutic radiation to a particular patient.

The application discloses a kind of targeted nanomedicine for treating radiation-resistant NSCLC and its preparation method and application, and belongs to the medical technical field, wherein the preparation method of targeted nanomedicine includes the following steps: using NaGdF4 as core, mesoporous silica as carrier, NaGdF4 is coated, and radio-sensitizing nanomaterial is obtained;Radio-sensitizing nanomaterial is co-incubated with PD-1 protein, and the targeted nanomedicine for treating radiation-resistant NSCLC is obtained.The application regulates radiation-resistant NSCLC tumor immune microenvironment by constructing radiosensitizing nano platform and loading PD-1 protein, controls the proliferation, migration and invasion of radiation-resistant NSCLC cells, successfully reverses the radioresistance of NSCLC, and significantly enhances the response of resistant cells to radiotherapy.The method provides valuable insights for developing targeted nanotherapeutic drugs to effectively treat NSCLC.

One or more example embodiments of the present invention relates to a fin for collimating therapeutic radiation. The fin comprises a collimation area made of a first material and a holding area made of a second material. Herein, the collimation area and the holding area are pressed together. Herein, the first material is formed to collimate therapeutic radiation. Herein, the holding area can be coupled to an adjustment device for adjusting the fin.

The present invention provides a compound and use thereof, particularly a JWA gene agonist and use thereof in preventing or treating radiation damage. The compound, by means of activating JWA gene expression, enhances the DNA repair capacity of cells, and has a good elimination capacity for highly active oxygen species generated by X-ray radiation. The compound can also effectively inhibit cell apoptosis caused by radiation to reduce the damage, and further reduce the generation of free radicals to reduce the probability of radiation damage.

Disclosed is use of Cordyceps sinensis MBF1 in the preparation of a health product or drug for preventing and / or treating radiation injury, particularly in the preparation of a health product or drug for preventing and / or treating intestinal radiation injury and / or hematopoietic radiation injury caused by ionizing radiation. Cordyceps sinensis MBF1 can significantly ameliorate symptoms caused by intestinal radiation injury, such as shortened colon length, small intestinal tissue injury, and elevated small intestinal inflammation level, ameliorate symptoms caused by hematopoietic radiation injury, such as reduced white blood cell count, reduced spleen index, and / or reduced thymus index, and can be used as a health product or drug for preventing and treating radiation injury, particularly intestinal radiation injury and / or hematopoietic radiation injury, thereby addressing the current lack of effective health products or drugs for the clinical treatment of intestinal radiation injury and / or hematopoietic radiation injury. In addition, the present disclosure provides a new idea and strategy for developing an anti-radiation injury health product or drug and demonstrates important scientific significance and clinical application value.

The application discloses a traditional Chinese medicine pair for treating radiation enteropathy and application thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine pair comprises the following components in parts by weight: 2-20 parts of cortex fraxini and 2-20 parts of radix scrophulariae. The cortex fraxini has the effects of astringing and stopping dysentery, the radix scrophulariae has the effects of clearing heat and drying dampness, and the cortex fraxini and the radix scrophulariae have the effects of clearing heat and resolving toxins, invigorating the spleen and removing dampness, and astringing intestines and stopping dysentery, and have the effect of treating radiation enteropathy. The application solves the problem that effective drugs for treating radiation enteropathy are lacked in the prior art.

The invention discloses application of chicoric acid in preparation of a medicine for improving hematopoietic injury caused by radiation, and belongs to the technical field of biological medicine. In order to solve the problem that an effective intervention means for hematopoietic system injury caused by ionizing radiation is lacked in the prior art, the invention provides application of chicoric acid in preparation of drugs for improving hematopoietic injury caused by radiation, and shows a dual protection mechanism of chicoric acid acting on a hematopoietic differentiation key regulation node. The hematopoietic function is synergistically improved by regulating EPO and other hematopoietic factors and progenitor cell populations, meanwhile, the anti-oxidation effect is achieved, radiation damage is relieved, definite active ingredients and action targets are provided for preparing the medicine for preventing and treating hematopoietic damage caused by radiation, and the application value of clinical transformation is achieved.

A radiation therapy system may be provided. The system may include a therapeutic apparatus. The therapeutic apparatus may include a radiation source for directing therapeutic radiation to at least one portion of a region of interest (ROI) of a subject, and an immobilizing device for immobilizing the subject. The system may obtain characteristics information of the subject. The system may preheat the immobilizing device according to a predictive model that processes the characteristics information of the subject. The system may send a control signal to the therapeutic apparatus for applying the therapeutic radiation to the at least one portion of the ROI immobilized by the preheated immobilizing device when the immobilizing device is preheated to a certain temperature.

The invention relates to a magnetic resonance imaging radiotherapy system capable of reducing interference on treatment radiation. The system comprises: a magnetic resonance imager (110) comprising a magnet (120) surrounding an aperture (130); a radiation therapy device (140) configured for radiating a therapy beam (160) having a respective radial beam path towards the aperture (130) from a plurality of locations around a longitudinal axis (150) of the aperture; a cold head (170) positioned outside the beam path; and a thermally conductive cooling section (180) in thermal connection with the cold head (170). The cooling section (180) extends azimuthally about a longitudinal axis (150) of the bore. The cooling section (180) is positioned to intersect the beam path, and the width (w) of the cooling section is greater than the maximum width of the treatment beam (180). Preferably, the attenuation of the treatment beam (160) caused by the cooling section (180) is constant between respective beam paths from different positions around the longitudinal axis (150) of the bore.

Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.

Described is a method of determining whether repair or replacement of an electron gun of a radiotherapy device should be scheduled. The radiotherapy device comprises a linear accelerator and is configured to provide therapeutic radiation to a patient. The radiotherapy device comprises a vacuum tube comprising the electron gun, a waveguide configured to accelerate electrons emitted by the electron gun toward a target to produce said radiation. The radiotherapy device comprises also comprises a current sensor, the current sensor being configured to provide signals indicative of current supplied to the electron gun. The method comprises receiving a current value, processing the current value, and based on the processing of the current value, determining whether repair or replacement of the electron gun should be scheduled. Processing the current value comprises determining whether the current value meets at least one threshold criterion, and determining whether the current value has changed by at least a threshold amount in a particular time period.

The invention relates to the technical field of thermal therapy machines, in particular to a deep thermal therapy microwave generating device of a multi-phase control type microwave solid-state source, which comprises a thermal therapy machine body and a control system, and is characterized in that the control system is used for controlling the thermal therapy machine body and comprises a temperature sensing unit and a processing unit; the system comprises a processing unit, a microwave 915MHz solid-state source unit, a microwave 915MHz solid-state source treatment radiation probe control unit, a tumor thermal therapy planning unit, an early warning unit and a control unit, and the processing unit is used for processing temperature data and calculating thermal dose. According to the invention, the temperature sensing unit adopts an anti-interference optical fiber multi-path temperature measurement sensor, temperature data is accurately acquired, the problem that the target region temperature is difficult to measure without damage is solved, and reliable temperature monitoring is provided for the thermal therapy process. The microwave 915MHz solid-state source unit provides a plurality of independent and controllable power output channels, so that the heat dose can be flexibly adjusted, and different tumor treatment requirements can be met.

The application relates to application of a molecular medicine in prevention or treatment of systemic damage induced by radiation (especially ionizing radiation with greater damage). The application research shows that a small molecule medicine MEC1 can improve the overall survival state of an ionizing radiation subject, significantly prolong the survival time of the radiation subject, reduce weight loss, reduce damage of multiple organ tissues such as thymus, spleen, small intestine, lung, skin, liver, kidney, muscle, heart and brain tissue, and show obvious protection, and can improve hematological, serum biochemical and immune homeostasis abnormalities, improve blood routine and serum biochemical abnormalities, relieve imbalance of B / m ratio, and show improvement or improvement trend on neurological behavior abnormalities and heart function changes, and can be used for prevention, reduction or treatment of systemic damage induced by ionizing radiation, and provides wide protection on multiple organs and tissues. Moreover, the small molecule has high safety, and has important and wide application value in anti-radiation products and radiation damage repair products.

The invention relates to a laser treatment device (1) comprising a device base (26), an application arm (12) fastened to the device base (26) and a laser light source (28) for generating treatment radiation (30), the application arm (12) having at least one working position (32) in which the application arm (12) is designed to guide the treatment radiation (30) into a processing region (22). Known laser treatment devices (1) have the disadvantage that the pre-positioning (P1) must be repeated when incorrectly performed, thereby increasing preparation time and reducing patient comfort. According to the invention, this is improved in that the laser treatment device (1) also has a projection unit (6) for simplifying the positioning of the person (22b) to be treated relative to the laser treatment device (1), and the projection unit (6) is designed to project a positioning mark (20) in such a way that the positioning mark represents the position of the processing region (22).

A method for performing ablative radiotherapy includes registering a first coordinate system of a tracking system for tracking a distal end of an intra-body catheter with a second coordinate system of a beam-directing system, tracking the location of a distal end of the catheter, receiving instructions from a user to ablate target tissue within the body with the beam-directing system and based on the registration and the tracking, aiming the beam-directing system at the target tissue so as to facilitate directing the therapeutic beams of radiation at the target tissue.

Embodiments of the present specification provide a treatment apparatus comprising a magnetic resonance imaging (MRI) apparatus for acquiring MRI data regarding a region of interest (ROI), and a radiotherapy apparatus, where the MRI apparatus comprises an annular cryostat comprising: one or more chambers arranged along an axis of the annular cryostat; the annular structure device surrounds the one or more cavities, the annular structure device comprises a plurality of annular structures, and the radiation beams penetrate through the annular structures; the degree of scattering of the radiation beam through the annular cryostat is reduced by reducing the effective thickness of the annular cryostat and / or controlling the depth of the cooling medium contained in the one or more chambers; the radiotherapy device is used to apply therapeutic radiation to at least a portion of the ROI.