25results about How to "Reduce dose" patented technology

The present application belongs to the technical field of pesticides, and particularly relates to a fungicide composition for preventing and treating vine gummy stem blight. The fungicide composition for preventing and treating vine gummy stem blight is prepared by compounding thymol with monensin sodium or physcion methyl ether as effective components. The fungicide composition of the present application has different fungicidal mechanisms of thymol, monensin sodium and physcion methyl ether, and the combination of the three components can delay the accumulation and development of pathogenic fungi resistance, and effectively overcome the problems existing in the prevention and treatment of vine gummy stem blight by using single-component pesticides. In addition, the effective components of the fungicide composition of the present application have a synergistic effect on vine gummy stem blight, can improve the prevention and treatment effect on vine gummy stem blight, help to reduce the application dose of the pesticide, and effectively overcome the problems of pesticide residue exceeding the standard and environmental pollution. Furthermore, thymol, monensin sodium and physcion methyl ether in the fungicide composition of the present application are environmentally friendly and green.

This invention relates to a highly active effective fraction of the Epiglottis-Clearing Decoction and its application in the preparation of antitussive drug compositions, belonging to the field of traditional Chinese medicine extract technology. The effective fraction contains hydroxysaffron yellow A, paeoniflorin, naringin, and neohesperidin, with the total content of these four components not less than 20% of the total mass of the effective fraction. The effective fraction of this invention is prepared by purification with macroporous resin. Compared with the freeze-dried powder of the traditional Epiglottis-Clearing Decoction, the total content of the four active ingredients is increased from 3.32% to 20.87%, achieving a more than 6-fold high-efficiency enrichment. Animal pharmacodynamic experiments show that the antitussive effect of a low dose (275.5 mg / kg) of this effective fraction is comparable to that of the freeze-dried powder of the original decoction (1928 mg / kg), reducing the dosage to about 1 / 7 of the original formula, demonstrating a significant "synergistic effect with reduced dosage" technical effect. The effective active ingredients provided by this invention have a clear content and stable quality, and can be made into modern preparations such as tablets, capsules or granules, solving the problems of large volume, inaccurate dosage and poor patient compliance of traditional decoctions.

This invention relates to a spatial multi-layer ultra-high pressure belt dewatering system and method, comprising a main frame, a feeding device, a feeding device, a filter belt, a filter belt traction machine, a filter press hydraulic press, a hydraulic station, and a controller. The feeding device, feeding device, filter belt traction machine, and filter press hydraulic press are connected and installed on the main frame; the output end of the feeding device is connected and installed above the feeding device. The dewatering method includes starting the equipment, feeding, filter press dewatering, and unloading. This invention offers higher dewatering efficiency and lower cost, making it a more effective organic waste dewatering device for reducing pollution and carbon emissions.

The present disclosure relates to a sewage treatment plant operation control method and system. The operation control method applied to a sewage treatment system comprises: obtaining a functional relationship between the settling flux and the sludge concentration of the secondary sedimentation tank; obtaining a first solid flux value corresponding to the settling flux under the current sludge concentration condition of the secondary sedimentation tank according to the functional relationship; obtaining a second solid flux value corresponding to the intersection position of the underflow flux and the overflow flux of the secondary sedimentation tank under the current sludge concentration condition; and controlling the dosing module to start the dosing mode when the second solid flux value is greater than the first solid flux value.

The invention relates to the technical field of drinking water treatment, and discloses a multifunctional and integrated composite micro-polluted underground water treatment device and method.The device is mainly composed of three main devices including an aeration column, a chemical crystallization circulating granulation fluidized bed and a catalytic oxidation filter column and a matched system; the aeration column aerates the raw water subjected to acid adding treatment to reduce the alkalinity of the raw water, the chemical crystallization circulating granulation fluidized bed can remove hardness, iron and manganese in incoming water, effluent of the crystallization fluidized bed enters the catalytic oxidation filter column to be filtered, and manganese, ammonia nitrogen, bacteria and microorganisms in the water are further removed through an internal catalytic oxidation active filter material; the whole set of system combination of the multifunctional and integrated composite micro-polluted underground water treatment device can achieve the functions of softening, iron removal, manganese removal, turbidity removal, ammonia nitrogen removal, bacteria removal and microorganism removal on micro-polluted underground water, and effluent can directly reach the drinking water standard.

The invention relates to the technical field of oil and gas fracturing flow-back fluid treatment, and particularly discloses a boron-doped diamond electrode electrooxidation system and method for treating fracturing flow-back fluid. According to the method for treating the fracturing flow-back fluid, before the fracturing flow-back fluid enters an electrooxidation unit, sulfide is efficiently removed, poison and competitive oxidation of the fracturing flow-back fluid to an electrode are eliminated, a BDD electrode is protected, a foaming agent is synchronously removed through aeration enrichment, the problem of foam interference in the flow-back fluid treatment process is fundamentally solved, and continuous and stable operation of a system is guaranteed; after the electro-oxidation unit, active chlorine (pypocholoride / chlorine) is effectively removed and recycled, so that waste is treated by waste, the oxidation efficiency is improved, and the dosage of chemicals is reduced. Through the collaborative design, the interference and foam problems of sulfide with high chloride ion content and strong reducibility are collaboratively optimized, and the treatment efficiency, economical efficiency and stability of the system are integrally improved.

The invention discloses a control method of a powder carbon backflow recycling technology in advanced sewage treatment, and the control method comprises the following steps: S1, before sewage treatment, early-stage work preparation is carried out in advance, and related facility transformation and debugging are carried out on working equipment. According to the UCR tank, the discharged carbon mud flows back to the water inlet of the UCR tank again, organic matters in water can be repeatedly adsorbed until the powdered carbon reaches an adsorption saturation state, and the adsorption capacity of the powdered carbon is fully utilized on the premise that the effluent reaches the standard, so that the economic benefit is maximized; moreover, through regular operation of adding new charcoal for 4 days and refluxing charcoal mud for 6 days, the new powdered charcoal adding amount can be saved by about 60% compared with that before transformation, the time for adding powdered charcoal all year round is about 8 months, the average using amount of powdered charcoal every day is about 1 ton, about 240 tons of powdered charcoal is used all year round, and 144 tons of powdered charcoal can be saved after transformation.

The invention belongs to the field of biological medicine, and particularly relates to a 5 'UTR sequence and application thereof. The technical problem to be solved by the invention is to improve the expression efficiency of mRNA drugs. The main technical scheme of the invention is as follows: two 5 'UTR sequences, which are SEQ ID NO: 1 and SEQ ID NO: 2, are provided; and a nucleic acid molecule comprising the 5 'UTR sequence. Compared with a 5 'UTR sequence optimized in the nature, the mRNA constructed by the 5' UTR has the advantages that the expression efficiency of a target gene is obviously improved; the preparation method is beneficial to reducing the administration dosage and administration frequency of the mRNA drug, reducing the cost of the mRNA drug and reducing the risk of adverse reaction after administration, and has a good application prospect in the industrial production of the mRNA drug.

The present application relates to the technical field of biological medicine, in particular to a kind of nano-molecular probe with targeting and its preparation method and application.The plasmid of immune checkpoint corresponding receptor of stable expression tumor surface negative regulation molecule is synthesized in the present application, which is prepared into targeted nano-molecular probe with cell membrane nanocapsule of enhancing T cell activity ligand and being marked with fluorescence, and melanin nanosphere of simultaneously loading therapeutic drug.The targeted nano-molecular probe provided in the present application can be long-circulated in vivo, reduce the dosage and administration frequency of chemotherapeutic drug.It also has the advantages of improving the drug resistance of tumor site to therapeutic drug, targeting tumor DNA damage and significantly enhancing the infiltration and activation of immune cells in tumor site.

This invention relates to a nuclear-targeted multimodal imaging diagnostic probe with BNCT therapeutic efficacy, its preparation, and its application, belonging to the fields of biomedicine and nuclear medicine technology. This boron drug contains... 10 Using acetylacetone difluoroborate as the parent nucleus, this invention endows the tumor with nuclear targeting ability by introducing N- or S-containing heterocyclic structures, while utilizing its conjugated structure to provide fluorescence / photoacoustic dual-modal imaging functionality. Based on this, the invention achieves three core functions: first, through fluorescence / photoacoustic dual-modal imaging, it enables the visual localization and real-time monitoring of tumor sites; second, by leveraging the binding of nuclear targeting groups to nuclear DNA / RNA, it... 10 B is precisely delivered into the nucleus, significantly improving the killing efficiency of BNCT; thirdly, thermal neutron irradiation is performed under imaging guidance, triggering... 10 The B(n,α)⁷Li nuclear fission reaction ultimately enables high-precision integrated diagnosis and treatment. This invention also discloses a method for preparing this probe, which has promising clinical application prospects.

This invention provides a pharmaceutical composition containing hezemibrate and an HMG-CoA reductase inhibitor, and may further include one or more excipients selected from calcium carbonate, butylated hydroxyanisole, butylated hydroxytoluene, citric acid, sodium lauryl sulfate, polysorbate, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, hydroxypropyl cellulose, lactose, pregelatinized starch, magnesium stearate, and talc. This composition can be formulated into various dosage forms, exhibiting good formulation stability and controllable quality.

This invention relates to a CDK12 / PARP dual-target inhibitor, its preparation method, and its application. The inhibitor has the general structural formula (I). Specifically, it relates to a CDK12 / PARP dual-target inhibitor, its preparation method, and its application. Pharmacodynamic studies have demonstrated that the CDK12 / PARP dual-target inhibitor of this invention has significant anti-tumor efficacy. The CDK12 / PARP dual-target inhibitor comprises substituted compounds having the general formula (I), or their stereoisomers, hydrates, or pharmaceutically acceptable salts. Compared with the prior art, the compound structure of this invention is novel, and experiments show that it has good CDK12 and PARP enzyme inhibitory activity, and can be used to prepare drugs with CDK12 / PARP dual-target anti-tumor activity.

This invention discloses a continuous ultrasonic amplification standing wave field-ozone micro-nano bubble synergistic inactivation device for mariculture, comprising a seawater pretreatment unit, an ozone micro-nano bubble generating unit, an ultrasonic amplification standing wave field-ozone micro-nano bubble synergistic inactivation reaction unit, a multi-parameter effluent detection unit, and a closed-loop control unit connected in sequence. The reaction chamber adopts a three-layer coaxial nested configuration of 316L stainless steel. The inner tube wall has a regular polygonal prism structure, while the outer tube wall has a multi-segment continuously circulating "gradually expanding-constant diameter-gradually contracting" irregular tube structure. High- and low-frequency multi-array ultrasonic transducers are correspondingly arranged on the inner and outer wall surfaces to synergistically construct a blind-zone-free gradient amplification standing wave field. This invention achieves efficient and continuous inactivation of pathogenic microorganisms in mariculture water by targeting and enriching pathogenic microorganisms at the acoustic pressure nodes of the standing wave field, concentrating the excitation of multi-frequency resonant cavitation effects at the acoustic pressure antinodes, and coupling ozone micro-nano bubbles to reduce the cavitation threshold and leverage their high oxidizing properties.

The present application relates to the technical field of therapeutic cyclic peptide-containing polypeptides, in particular, to a cyclic peptide-containing polypeptide compound, application thereof and a long-acting amylin drug. The cyclic peptide-containing polypeptide compound is selected from the compounds shown in the following structural formula: wherein (Lactm bridge: Asp3-Lys8) represents an intramolecular lactam bridge formed between the side chain of the third amino acid Asp and the eighth amino acid Lys residue counted from the R1 end; R1 represents, R2 is independently selected from any one of carboxyl, carboxylate, tetrazole, phosphate, phosphate ester, sulfonic acid and sulfonate; n is any integer in 10-24; X 15 , X 16 , X 17 , X 22 , X 23 , X 24 , X 25 , X 26 and X 28 are independently selected from amino acids. As a novel amylin drug, the cyclic peptide-containing polypeptide compound is a multi-target drug, has good biological activity and bioavailability.

The invention belongs to the technical field of water treatment, and particularly relates to an adsorption material of an organic phosphonic acid group modified metal oxide and hardness removal application thereof.The adsorption material takes a metal oxide as a carrier, and surface functionalization modification is conducted on the metal oxide through organic phosphonate containing a plurality of organic phosphonic acid functional groups; wherein part of the organic phosphonic acid functional groups are combined with the surface of the metal oxide, and the rest of the organic phosphonic acid functional groups are modified on the surface of the metal oxide; the adsorption material serves as a water treatment agent under the water treatment condition that the pH value is 8 or above, and organic phosphonate functional groups for surface modification are combined with hardness ions in water through complexation, so that deep hardness removal is achieved. The adsorption material prepared by the method can deeply remove trace calcium and magnesium hardness ions in a water body through specific complexation under a mild condition close to neutral, and the pH value does not need to be greatly adjusted, so that the addition of agents such as acid and alkali is remarkably reduced.

This invention discloses a method for treating hazardous waste liquid, comprising the following steps: mixing the hazardous waste liquid to be treated with polyferric sulfate evenly and then subjecting it to electron beam irradiation. In this method, before electron beam irradiation, polyferric sulfate is added to the hazardous waste liquid to be treated, mixed evenly, and then directly subjected to irradiation. This allows the catalytic oxidation effect of the synergistic irradiation treatment to more thoroughly treat the pollutants in the wastewater, while requiring a smaller dosage of the reagent.

The utility model discloses a two -segmented mine water is coordinated and is removed turbidity, removes fluorine precipitate processing device, including the turbidity removal sedimentation section and the coordinated sedimentation section who sets up in intercommunication, turbidity removal sedimentation section includes one stage first mixed area, one stage second mixed area, one stage flocculation area and one stage sedimentation area, and one stage sedimentation area and one stage second mixed area still are connected with one stage circulation area, the coordinated sedimentation section includes two stage first mixed area, two stage second mixed area, two stage flocculation area and two stage sedimentation area, and two stage sedimentation area and two stage second mixed area still are connected with two stage circulation area, and one stage sedimentation area intercommunication two stage first mixed area, the utility model discloses a turbidity removal sedimentation section and the coordinated sedimentation section who sets up in intercommunication, and turbidity removal sedimentation section reduces the turbidity through higher hydraulic load, and reduces the suspended solids in mine water, and in the coordinated sedimentation section water, there is a certain amount of suspended solids and microsand together with the improvement coal slime's drop characteristic, and the sedimentation effect is improved.

The present application relates to the technical field of genetic engineering, and provides application of locust Reeler gene and coded protein thereof in prevention and treatment of locusts, wherein the polynucleotide sequence of the locust Reeler gene comprises a sequence shown in SEQ ID NO:1, a complementary sequence, a degenerate sequence, a truncated sequence, or a homologous sequence or a complementary sequence having 90% or above identity with SEQ ID NO:1 and hybridizing under stringent conditions. The present application can design and synthesize interference molecules for specifically silencing the target gene by providing a molecular target of the Reeler gene, so as to specifically inhibit expression of the Reeler gene in the group-living locusts, thereby providing a key molecular basis for weakening the immune defense ability of the locusts to Metarhizium anisopliae, and realizing synergistic effect of immune sensitization and biological killing.

The present application relates to a kind of atomization and inhale type atomization administration device, including upper shell, lower shell, dosing control component, drug storage component, atomization component and power supply component, the drug storage component is set in upper shell, for providing drug liquid to atomization component;The atomization component is arranged between upper shell and lower shell, for atomizing the drug liquid provided by drug storage component;The dosing control component is used to control the work of atomization component;The power supply component is used to power dosing control component and atomization component;Atomization outlet is provided on the lower shell, for discharging the drug liquid after atomization, and the atomization administration device can store and atomize liquid drug preparation, and provide patient with real-time atomization inhalation, realize treatment or immunization effect etc..

The invention relates to a phenol polyethylene glycol derivative, a preparation method thereof and application of the phenol polyethylene glycol derivative in medicine. Specifically, the invention relates to a phenol polyethylene glycol derivative as shown in a general formula (A-I) or a stereoisomer, a tautomer or pharmaceutically acceptable salt thereof, and application in medicine, the structure of the compound as shown in the general formula (A-I) is shown in the specification, and the group definition of the compound is consistent with that of the specification.

The application discloses a kind of resource processing technology of nickel-containing etching waste liquid, comprising the following steps: S1, pretreatment: adding lye to nickel-containing etching waste liquid to adjust pH to 3.5~4.0, then heated stirring treatment, again, standing aging treatment, obtain containing nickel fluoride turbidity liquid;S2, centrifugal: the centrifugal treatment of containing nickel fluoride turbidity liquid;S3, main reaction: with hot water to clean nickel fluoride by-product, cleaning wastewater is added to the etching waste liquid after pretreatment, then add hydrofluoric acid to adjust the ratio of ammonium fluoride and hydrofluoric acid to 0.9~1.2:1, after reaction, obtain reaction liquid;S4, concentration;S6, centrifugal;S7, drying: ammonium bifluoride crystal is dried to obtain ammonium bifluoride product.The application controls precipitated nickel fluoride by adjusting process conditions, solves the influence of nickel-ammonium complexation on the direction of treating nickel-containing etching waste liquid by precipitation method by pH control, reduces auxiliary material addition and environmental pollution, realizes resource recycling, and reduces production cost.

This invention belongs to the field of biomedical technology, specifically relating to muscle-targeting AAV capsid variants, recombinant AAV, and their applications. To improve the muscle tissue transduction efficiency of AAV and reduce liver tropism, this invention provides a muscle-targeting AAV capsid variant protein, which is a polypeptide that enhances the muscle cell or tissue targeting of AAV capsid protein and reduces liver tropism by substituting, inserting, and / or deleting at least one polypeptide in the variable region VIII of the parental AAV capsid protein VP1. Experimental results demonstrate that the AAV capsid protein variant of this invention has high transduction efficiency, significantly increases gene expression in muscle tissue, and possesses cross-species characteristics, enabling efficient transduction of muscle tissue and reducing liver tropism in mice and non-human primates. Clinical data indicate that AAVM101.μDys prepared based on the AAV capsid protein variant of this invention has good safety and efficacy in the treatment of DMD, laying a clinical foundation for further research.

The invention discloses a treatment system and method for photoelectrocatalytic degradation of degradation-resistant organic matter wastewater, and belongs to the field of environmental electrochemical engineering. The system comprises a pretreatment unit, a photoelectric catalytic reaction core unit and a post-treatment unit. A core unit innovatively adopts a three-dimensional porous composite photo-anode and a gas diffusion cathode, so that the problems that a catalyst is easy to lose and inactivate due to pollution and the utilization efficiency of the catalyst and light is low are effectively solved. According to the treatment method, after the pH value of the wastewater is regulated and controlled, under illumination or additional bias voltage, hydroxyl radicals are generated by cooperating with photoelectric oxidation, and a Fenton-like reaction is initiated by in-situ production of hydrogen peroxide by a cathode, so that high-efficiency removal of refractory organic matters is realized. The process technology is simple, the system operation is stable, the energy consumption is low, the secondary pollution is less, and the method is suitable for pretreatment or advanced treatment of Baijiu with different concentrations and different turbidity or other wastewater.

This invention discloses an apparatus and method for coupling ferroammonia oxidation and anaerobic ammonia oxidation of Fenton waste sludge, comprising an influent tank, a five-stage reactor, a secondary sedimentation tank, and a Fenton reactor connected in sequence. This invention enriches the ferroammonia-oxidizing bacteria in the activated sludge by recirculating the sludge (containing ferric iron) produced in the Fenton reactor to the five-stage reactor. The nitrite and nitrate nitrogen produced by ferroammonia oxidation are directly or indirectly utilized by anaerobic ammonia-oxidizing bacteria on the packing material for anaerobic ammonia oxidation. The nitrate nitrogen produced in the aerobic zone can be denitrified using carbon sources and ammonia nitrogen in the influent through short-cut denitrification anaerobic ammonia oxidation. This invention achieves volume reduction and harmless treatment of Fenton waste sludge, achieving high nitrogen and phosphorus removal efficiency in industrial wastewater while removing recalcitrant organic matter.

This invention relates to the pharmaceutical field, specifically to a paeoniflorin-6-O'-benzenesulfonate fat emulsion injection with a specific compound carrier and its preparation method. The formulation of this invention comprises the following components in the indicated mass ratios: 1.5%–5.5% solid dispersion, 10%–30% oil phase solvent, 3%–10% isotonic adjuster, 0.1%–1% pH adjuster, and the balance being water for injection; the solid dispersion is formed by mixing paeoniflorin-6-O'-benzenesulfonate with a compound carrier. This invention first prepares paeoniflorin-6-O'-benzenesulfonate into a solid dispersion, and then prepares a fat emulsion to increase the lipid solubility of paeoniflorin-6-O'-benzenesulfonate, thus solving the problem that paeoniflorin-6-O'-benzenesulfonate is insoluble in the oil phase and cannot be used to prepare fat emulsion injections. It also improves the stability and membrane permeability of easily degradable paeoniflorin-6-O'-benzenesulfonate, reducing the dosage. The prepared particles are smaller, more stable, have higher drug loading, and higher encapsulation efficiency. Furthermore, it solves the problem of slow absorption in the gastrointestinal tract, and by using injection, it significantly improves bioavailability.