136results about How to "Reduce dose" patented technology

The invention discloses a polypeptide derivative with a GCGR, GIPR and GLP-1R triple targeting agonistic effect as well as a preparation method and application of the polypeptide derivative, the polypeptide derivative is shown as a formula (I), (II) is a branched chain modification structure of a peptide chain, and the group definition is detailed in the specification. The polypeptide derivative compound and the pharmaceutically acceptable salt thereof provided by the invention can be used for treating metabolic related diseases such as diabetes mellitus, weight loss, MASH and the like, cardiovascular and cerebrovascular diseases and / or neurodegenerative diseases. Tyr-Aib-Gln-Gly-Thr-Ph-Thr-Ser-Asp-Tyr-Ser-Xaa12-Xaa13-Leu-As-Lys-Xaa17-Ala-Gln-Xaa24-Xaa25-Leu-Leu-Xaa28-Gly-Ala-Pro-Pro-Ser-NH2 (I) # imgabs0 #

The invention belongs to the technical field of cosmetics, and provides an external composition with soothing and anti-inflammatory effects, a preparation and application thereof. The external composition is prepared from the following components in parts by weight: 4 to 5 parts of herba violae extract, 4 to 5 parts of chamomile flower extract, 1 to 3 parts of dandelion rhizome / root extract, 1 to 3 parts of Chinese herbaceous peony root extract, 1 to 3 parts of honeysuckle flower extract, 1 to 3 parts of mallow flower extract and 0.001 to 0.1 part of aloe barbadensis leaf extract; wherein the taraxacum vulgare rhizome / root extract is prepared by the following steps: smashing taraxacum vulgare rhizomes / roots, extracting with an ethanol-water solution, concentrating an extracting solution, carrying out enzymolysis with a compound enzyme preparation, and purifying with a macroporous adsorption resin column, so as to obtain the taraxacum vulgare rhizome / root extract. The content and the yield of the effective active ingredient total flavonoids in the taraxacum chinense rhizome / root extract in the external composition are high, and the composition has the advantages of being small in dosage and good in relieving and anti-inflammatory effect on allergic skin.

The invention belongs to the field of medicine, and particularly discloses a deuterated tetrahydrofuran NaV1.8 inhibitor and application thereof, and the NaV1.8 inhibitor comprises a compound shown as a formula I or pharmaceutically acceptable salt and solvate thereof; wherein R1 and R2 are respectively and independently selected from H and deuterated C1-3 alkyl groups. The NaV1.8 inhibitor adopts a deuterated tetrahydrofuran medicine, the pharmacokinetic property of the NaV1.8 inhibitor can be remarkably improved, the administration dosage and toxic and side effects can be reduced, specifically, the channel activity IC50 of the NaV1.8 is lower than 0.1 nmol / L, the inhibitory activity IC50 of the NaV1.8 is lower than 43 nmol / L, the oral pharmacokinetic parameter t1 / 2 is 5.2 + / -1.2 h, and the NaV1.8 inhibitor is remarkably superior to a commercially available VX-548 preparation. # imgabs0 #

The invention belongs to the technical field of wastewater treatment, and provides a method for realizing continuous degradation of pollutants under a low dosage based on a self-assembly induced carbon confinement material, which comprises the following steps: adding peracetic acid and a carbon confinement material into wastewater containing organic pollutants, treating the wastewater under a stirring condition, and in the wastewater treatment process, adding the peracetic acid and the carbon confinement material into the wastewater, the carbon confinement material activates peracetic acid to generate hydroxyl free radicals, organic free radicals, singlet oxygen and Co (IV) to degrade organic pollutants in the wastewater; the carbon confinement material is composed of a cobalt material and a nitrogen-doped carbon material coating the cobalt material, the cobalt material is composed of Co and CoO, and the carbon confinement material is nanoparticles with a core-shell structure. According to the invention, the high-efficiency utilization of the oxidizing agent peracetic acid can be realized under the condition of low-carbon confinement material dosage, the continuous degradation of micropollutants can be mediated, and the treatment cost of wastewater containing organic pollutants can be reduced.

The invention discloses a microneedle patch loaded with a sorafenib and copper-doped Prussian blue nano material and application of the microneedle patch in in-situ triple-negative breast cancer treatment. The sorafenib and the copper-doped Prussian blue nano material are loaded in a needle body of the microneedle patch. The microneedle patch can accurately deliver nanoparticles and sorafenib to tumor tissues, the chemical kinetics effect is enhanced through an efficient and mild photothermal therapy, the ferroptosis of triple negative breast cancer cells is enhanced through ferroptosis induced by the nanoparticles and sorafenib in cooperation with drugs, then cell death is induced, and the curative effect is improved. And a brand-new and promising treatment method is provided for in-situ triple-negative breast cancer treatment.

The invention relates to an andrographolide nanocrystal suspension, preparation thereof and application of the andrographolide nanocrystal suspension in preparation of an andrographolide nanocrystal dry powder inhaler with an anti-inflammatory effect. The andrographolide nanocrystal suspension contains a) an active component andrographolide nanocrystal; b) a stabilizer; wherein the content of andrographolide in the suspension is 0.1%-30%, and the content of the stabilizer is 0.1%-5%. According to the andrographolide nanocrystal dry powder inhalant and the preparation method thereof, andrographolide nanocrystals are prepared into micro powder by adopting a spray drying technology, and auxiliary material addition and a preparation process are optimized, so that the andrographolide nanocrystal dry powder inhalant with good inhalation performance is successfully prepared and directly acts on the respiratory tract through a pulmonary drug delivery system, the administration dosage is reduced, and the inhalation effect is improved. Higher lung local concentration is obtained, the first-pass effect of the liver is avoided, meanwhile, the efflux effect of p-glycoprotein is avoided as much as possible, and then the bioavailability is improved; the technical problem that the bioavailability is poor due to the fact that andrographolide is excreted through p-glycoprotein and rapidly absorbed and metabolized in the intestinal tract is solved.

The invention belongs to the technical field of sludge treatment, and particularly relates to an aerobic granular sludge sewage treatment process applied to a continuous flow activated sludge process. A pelletizing agent is added into a granular sludge incubator, so that the pelletizing agent is in targeted combination with filamentous bacteria in activated sludge to form granular sludge, the granular sludge and flocculent sludge are effectively separated through a cyclone separation system, the granular sludge continuously flows back into a biochemical system, and the flocculent sludge is discharged into a sludge concentration tank or a sludge storage tank for dehydration treatment. According to the present invention, the AGS is rapidly cultured and the stable operation is maintained in the current or new continuous flow activated sludge process, such that the treatment water amount of the traditional continuous flow sewage treatment process can be subjected to in-situ capacity expansion, the impact load resistance can be enhanced, the addition amount of the phosphorus and nitrogen removal agent can be reduced, and the in-situ excess sludge can be reduced.

The utility model discloses a disc ceramic membrane treatment device for high-solid-content and high-concentration materials. The disc ceramic membrane treatment device comprises a vertical rotary disc ceramic membrane unit, a material tank, a backwashing tank and a control unit, in the concentrating process in the field of high-concentration and high-solid-content materials, the viscosity change span is large, a conventional tubular ceramic membrane system or a rotary membrane system cannot be suitable for conveying the materials with large viscosity change, cross flow cannot be guaranteed, so that the membrane pollution speed is too high due to hole blockage of a tubular ceramic membrane or excessive concentration of an internal cavity, and the membrane pollution speed is too high. Therefore, the effect of high-multiple concentration cannot be achieved. A double-rotor pump conveying system and a constant-pressure control mode are adopted, the defect can be overcome, material conveying is guaranteed, and conveying and filtering in the field of high-concentration and high-viscosity materials can be achieved.

The invention discloses a device and method for simultaneously determining the detonation velocity and detonation pressure of micro-scale charge, and belongs to the technical field of detonation performance testing of energetic materials. The device comprises a laser, a charging system, a detonation velocity testing system and a detonation pressure testing system, the charging system comprises a charging clamp, a sample containing groove and a sample ring, the sample containing groove is fixed in the charging clamp, and the sample ring is assembled in the sample containing groove; the detonation velocity testing system comprises a probe, a direct-current power supply and an oscilloscope; the detonation pressure testing system comprises an optical fiber and a photon Doppler velocity tester. During use, a to-be-tested sample is pressed into the sample rings, the probe is embedded between the two sample rings, the to-be-tested sample is detonated by using energy provided by the laser, the detonation velocity and detonation pressure of the to-be-tested sample can be measured at the same time, the sample amount required by a single shot experiment is within 200 mg, and compared with a traditional test method, the sample consumption is greatly reduced, and meanwhile, the test safety is improved.

The invention discloses a pH-sensitive coaxial nanofiber membrane loaded with enoxacin as well as a preparation method and application of the pH-sensitive coaxial nanofiber membrane. The electrostatic spinning nanofiber membrane is composed of a shell layer and a core layer, the shell layer comprises ethyl cellulose and Eudragit L100, the core layer comprises ethyl cellulose and enoxacin, and the electrostatic spinning nanofiber membrane is prepared through the electrostatic spinning technology. Results show that the coaxial nanofiber has a good core-shell structure, is good in water absorption, can keep a wound surface wet, has certain tensile strength, is obvious in in-vitro bacteriostasis, and can effectively promote healing of the wound surface and revascularization. The research hot spot in the field of materials is creatively applied to a pharmaceutical preparation delivery system, the prepared pH-sensitive electrostatic spinning nanofiber membrane is used for tissue regeneration and repair, and a good effect is achieved in animal experiments. The defect that an existing wound field depends on a traditional treatment means is overcome, and a basis is provided for existing industrial production.

The invention discloses a spatial multilayer ultrahigh-pressure box-type dehydration system and a dehydration method. The system comprises a main rack, a material distributing and feeding device, a material distributing / discharging device, filter cloth, a filter pressing chamber, a filter chamber moving device, a filter chamber lifting hydraulic machine, a filter pressing hydraulic machine, a hydraulic station and a controller, the material distributing and feeding device, the material distributing / discharging device, the filter chamber moving device, the filter chamber lifting hydraulic machine and the filter pressing hydraulic machine are connected to the main machine frame, the material distributing and feeding device is installed on the material distributing / discharging device, the material distributing / discharging device is installed on the filter pressing chamber, the filter cloth is wound on the material distributing / discharging device, the filter pressing chamber is installed on the filter chamber moving device, and the filter pressing hydraulic machine is installed on the filter chamber lifting hydraulic machine. The filter chamber lifting hydraulic machine is installed below the material distributing / discharging device and the filter chamber moving device, the filter chamber moving device, the filter chamber lifting hydraulic machine and the filter pressing hydraulic machine are connected with the hydraulic station, and the material distributing and feeding device, the material distributing / discharging device, the filter chamber moving device, the filter chamber lifting hydraulic machine, the filter pressing hydraulic machine and the hydraulic station are electrically connected with the controller.

The invention relates to application of amlexanox and polydatin in preparation of a preparation for preventing and / or treating radiation-induced lung injury, and belongs to the technical field of medicines. The invention provides application of amlexanox combined with polydatin in preparation of a medicine for preventing and / or treating radiation-induced lung injury. The amlexanox and the polydatin are combined for use, so that the radiation-induced lung injury caused by ionizing radiation can be well prevented and / or treated, and the survival rate of a radiation-induced lung injury model mouse is increased by more than 50% on the premise of remarkably reducing the administration dosage of the amlexanox and the polydatin; the traditional Chinese medicine composition has the characteristics of small dosage, excellent prevention and / or treatment effect, no toxic or side effect and no dose dependence.

This invention relates to the application of a dual-active-component drug in the preparation of a drug for treating double-hit lymphoma. The active ingredients in the dual-active-component drug consist of a first active component and a second active component. The first active component is selected from homoharringtonine or a pharmaceutically acceptable salt thereof; the second active component is selected from veneclade or a pharmaceutically acceptable salt thereof. This invention demonstrates that homoharringtonine combined with veneclade can significantly inhibit the proliferation of DHL cell lines and induce apoptosis in DHL cell lines. Using a CDX mouse model, it was demonstrated that homoharringtonine combined with veneclade can inhibit the tumorigenesis process of mouse DHL. The combined use of the two active components not only reduces the dosage of each drug and improves drug safety, but also has a more significant effect on improving or treating double-hit lymphoma (DHL) than a single active component, exhibiting a synergistic effect.

The present invention provides the use of phenylquinolinone and flavonoid derivatives for neuropathic pain, and the phenylquinolinone and flavonoid derivatives include pharmaceutically acceptable salts thereof. The compound of the present invention is a histamine H3 receptor antagonist, which has a different mechanism of action from existing drugs and can be used in the preparation of drugs for treating neuropathic pain diseases. The effect of the compound of the present invention in treating neuropathic pain is better than amitriptyline, gabapentin, pregabalin and carbamazepine, indicating that the compound of the present invention has a better therapeutic effect, has the characteristics of small dosage, good efficacy, high bioavailability and safety, and compared with opioid drugs, the compound of the present invention is not addictive and is a very effective drug for treating neuropathic pain diseases. Therefore, the clinical application prospects are huge. The general structural formula is as follows:

The invention provides a system and a method for efficiently removing phosphorus from high-phosphorus easily-biodegradable wastewater, and relates to the technical field of sewage phosphorus removal, the system comprises a biological phosphorus removal tank, the inner part of the biological phosphorus removal tank is sequentially provided with an anaerobic zone and an aerobic zone along the water flow direction; the sedimentation tank is communicated with the aerobic zone; an aeration part of the aeration device is arranged in the sedimentation tank. The effluent of the biological phosphorus removal tank of the system enters the sedimentation tank to realize mud-water separation, and the oxygenation device arranged in the sedimentation tank can form an aerobic environment, so that secondary phosphorus release of phosphorus-accumulating bacteria in the sedimentation tank is inhibited, and the TP (Total Phosphorus) rise of the effluent of the sedimentation tank is avoided. According to the method, a biological phosphorus removal method is applied to treatment of the high-phosphorus easily-biodegradable wastewater, addition of chemical agents and generation of chemical sludge are greatly reduced, the treatment cost of the high-phosphorus wastewater is remarkably reduced, and the method is economical, efficient and free of secondary pollution.

An agent for suppressing inflammation in the intestinal cell of a non-human animal comprises cashew nut shell liquid, heated cashew nut shell liquid, anacardic acid, cardanol, and / or cardol, and vitamin K.

The utility model relates to a radiation dose adjusting device. The device comprises a radioactive source, a source switch and a shielding plate device, the radioactive source is arranged above the source switch, the shielding plate device is arranged below the source switch, the shielding plate device comprises a base, a light shielding plate, a light shielding plate driving device for driving the light shielding plate to rotate and a beam outlet, and the light shielding plate and the light shielding plate driving device are arranged in the base. The beam outlet is arranged at the bottom of the base, and the shading plate is provided with a notch corresponding to the beam outlet. According to the utility model, aiming at the irradiation dose differentiation requirement in the radiation treatment process, after the collimator with the proper focal length is selected, a certain dose of irradiation treatment is carried out on the focus area of a patient through the dose adjusting device.

The invention provides a triflumezopyrim-containing pesticide composition for preventing and treating sogatella furcifera, a pesticide preparation as well as a preparation method and application thereof, and belongs to the technical field of pest prevention and treatment. The nitenpyram and the pymetrozine are compounded with the trifluoro-benzene pyrimidine respectively, a synergistic effect is shown in a certain mass ratio range, the prevention and treatment effect on the sogatella furcifera can be improved (fast-acting property and persistent effect are achieved), the application dosage of chemical agents is reduced on the basis, and the prevention and treatment cost is reduced. The problems of pesticide residues, environmental pollution and the like caused by large-dose application are avoided to a certain extent.

The invention relates to the technical field of sewage treatment, in particular to an intelligent control system and method based on a five-section Bardellpho process, and the intelligent control system comprises a water inlet module, an aeration module, a backflow module, a sludge discharge module and a control module; the control module is respectively in communication connection with the water inlet module, the aeration module, the backflow module and the sludge discharge module; a first aerobic tank is divided into a low-oxygen area and a high-oxygen area, and ammonia nitrogen analyzers are mounted at the tail end of the high-oxygen area of the first aerobic tank and the tail end of a second aerobic tank respectively and used for collecting ammonia nitrogen concentrations of corresponding areas; dO monitors are respectively arranged at the tail ends of the low-oxygen zone of the first aerobic tank, the high-oxygen zone of the first aerobic tank and the second aerobic tank and are used for collecting the DO concentration of the corresponding zones. Based on the intelligent control system, the intelligent control method provided by the invention accurately controls the operation parameters to be in an optimized state. According to the invention, the effect of strengthening endogenous denitrification and efficient nitrogen removal is realized, refined operation is realized, and the operation efficiency is improved.

The present application belongs to the technical field of pesticides, and particularly relates to a fungicide composition for preventing and treating vine gummy stem blight. The fungicide composition for preventing and treating vine gummy stem blight is prepared by compounding thymol with monensin sodium or physcion methyl ether as effective components. The fungicide composition of the present application has different fungicidal mechanisms of thymol, monensin sodium and physcion methyl ether, and the combination of the three components can delay the accumulation and development of pathogenic fungi resistance, and effectively overcome the problems existing in the prevention and treatment of vine gummy stem blight by using single-component pesticides. In addition, the effective components of the fungicide composition of the present application have a synergistic effect on vine gummy stem blight, can improve the prevention and treatment effect on vine gummy stem blight, help to reduce the application dose of the pesticide, and effectively overcome the problems of pesticide residue exceeding the standard and environmental pollution. Furthermore, thymol, monensin sodium and physcion methyl ether in the fungicide composition of the present application are environmentally friendly and green.

The invention relates to the technical field of sewage treatment, and aims to solve the problems that a dissolved oxygen detector is limited in measuring range, an air inlet fan and an air inlet valve in a low-dissolved-oxygen area cannot be guided to act according to dissolved oxygen indexes, an efficient denitrification state cannot be maintained, a dephosphorization agent is added according to effluent total phosphorus, a dephosphorization agent adding point is the tail end of an aerobic II area, the feedback time is long, and the efficiency is high. The invention provides an optimized oxygen dissolving and dosing regulation and control method suitable for an A2O + MBR (Membrane Bioreactor) process, aiming at solving the problems of unstable total phosphorus in effluent caused by low control efficiency in the prior art. The method comprises the steps of data acquisition, medicament adding control and dissolved oxygen control. According to the invention, the opening degree of the fan and the joint action of the valves in the areas to be controlled are controlled through the oxidation-reduction potential, the linkage automatic control of the oxidation-reduction potential of the biochemical pool and the dissolved oxygen in the low dissolved oxygen area and the aerobic area is completed, the actions of the fan and the valves of the aeration system are effectively guided, and the efficient denitrification state can be maintained; the orthophosphate value at the tail end of the aerobic zone is used as the adding basis of the dephosphorization agent, so that the method is more accurate and efficient.

The object of the present invention is to provide a method that is safe and can control various pests at a low dosage, as well as a pest control composition and a pest control kit suitable for use in the method. The pest control method of the present invention applies at least one compound selected from the group consisting of compounds represented by formula (I) and salts thereof together with an insecticidal or acaricidal active ingredient to an object. In formula (I), R 1 is a substituted or unsubstituted C1-6 alkylthio group, a substituted or unsubstituted C1-6 alkylsulfinyl group, etc., R 2 is a hydrogen atom, or a substituted or unsubstituted C1-6 alkyl group, R is a C1-6 haloalkyl group, or a C2-6 haloalkenyl group, X is a substituted or unsubstituted C1-6 alkyl group, a substituted or unsubstituted C2-6 alkenyl group, etc., and n is any integer from 0 to 4. When n is 2 or more, X may be the same or different.

The invention belongs to the technical field of anti-tumor drugs, and particularly relates to application of allicin in preparation of an anti-tumor drug sensitizer and a tumor chemotherapy pharmaceutical composition, an A549 cell strain, a paclitaxel drug-resistant cell model A549 / Taxol and a tumor-bearing mouse model are established, and in-vivo and in-vitro pharmacodynamic research finds that the allicin can effectively inhibit cell proliferation and has a good anti-tumor effect. The apoptosis is induced, and the drug resistance of paclitaxel is reversed. The compound inhibits P-gp expression, reduces drug efflux and destroys cell autophagy. Particularly, allicin inhibits cathepsin B (CTSB), destroys lysosome functions, blocks autophagy flux, reduces mitochondrial membrane potential and enhances sensitivity to paclitaxel. The combination of allicin and paclitaxel can significantly inhibit the growth of tumor nodules and reduce the number of tumor nodules, shows the potential of reversing the drug resistance of paclitaxel in vivo, can significantly improve the chemotherapy effect of NSCLC, and has potential clinical application value.

This invention relates to a highly active effective fraction of the Epiglottis-Clearing Decoction and its application in the preparation of antitussive drug compositions, belonging to the field of traditional Chinese medicine extract technology. The effective fraction contains hydroxysaffron yellow A, paeoniflorin, naringin, and neohesperidin, with the total content of these four components not less than 20% of the total mass of the effective fraction. The effective fraction of this invention is prepared by purification with macroporous resin. Compared with the freeze-dried powder of the traditional Epiglottis-Clearing Decoction, the total content of the four active ingredients is increased from 3.32% to 20.87%, achieving a more than 6-fold high-efficiency enrichment. Animal pharmacodynamic experiments show that the antitussive effect of a low dose (275.5 mg / kg) of this effective fraction is comparable to that of the freeze-dried powder of the original decoction (1928 mg / kg), reducing the dosage to about 1 / 7 of the original formula, demonstrating a significant "synergistic effect with reduced dosage" technical effect. The effective active ingredients provided by this invention have a clear content and stable quality, and can be made into modern preparations such as tablets, capsules or granules, solving the problems of large volume, inaccurate dosage and poor patient compliance of traditional decoctions.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a preparation method of pirnenone sustained-release microsphere inhalation powder inhalation and application of the pirnenone sustained-release microsphere inhalation powder inhalation in treatment of idiopathic pulmonary fibrosis. Chitosan is subjected to mPEG modification to serve as a carrier material, the carrier material and pirfenidone are prepared into the drug-loaded microspheres through an electrostatic spraying technology, and the prescription and the preparation process for preparing the drug-loaded microspheres are optimized. The prepared PFND-mPEG-CS-MS has better encapsulation efficiency, drug loading capacity and in-vitro release behavior, and the characterization of a sample shows that the powder chemical properties of the PFND-mPEG-CS-MS meet the requirements of inhalation powder aerosols. In-vitro cell experiments show that the blank carrier microspheres have good biocompatibility, and the drug-loaded microspheres have high cell inhibition rate. Animal in-vivo experiment results show that the PFND-mPEG-CS-MS has remarkable significance in prolonging the half-life period of the medicine, improving the bioavailability of the medicine, improving the treatment effect and reducing the hepatotoxicity.

This invention relates to a spatial multi-layer ultra-high pressure belt dewatering system and method, comprising a main frame, a feeding device, a feeding device, a filter belt, a filter belt traction machine, a filter press hydraulic press, a hydraulic station, and a controller. The feeding device, feeding device, filter belt traction machine, and filter press hydraulic press are connected and installed on the main frame; the output end of the feeding device is connected and installed above the feeding device. The dewatering method includes starting the equipment, feeding, filter press dewatering, and unloading. This invention offers higher dewatering efficiency and lower cost, making it a more effective organic waste dewatering device for reducing pollution and carbon emissions.

The utility model belongs to the technical field of water treatment, and particularly relates to a hydrogen peroxide catalytic remover which comprises a barrel, a hydrogen peroxide catalytic remover body and a hydrogen peroxide catalytic remover body, a partition plate is arranged in the middle of the barrel, and a gap is formed between the periphery of the partition plate and the inner wall of the barrel; the tubular lower filter screen is fixedly arranged between the partition plate and the bottom wall of the barrel; and the tubular upper filter screen is fixedly arranged between the partition plate and the top wall of the barrel. Based on the technical scheme, a catalyst can be fixed through the upper filter screen, and wastewater can pass through the upper filter screen. The wastewater flows through the catalyst, and the hydrogen peroxide is catalytically decomposed. And the catalyst is not taken away by the wastewater when the wastewater flows through and is fixed in the upper filter screen.

The utility model relates to an atomizer mask which comprises a mask body provided with an air inlet and an air outlet and further comprises a mist storage tank and a connector. A medicine inserting opening is formed in one end of the mist storage tank, and a medicine outlet is formed in the other end of the mist storage tank; the connector is arranged at the end, close to the medicine outlet, in the mist storage tank and used for being connected with the medicine outlet and the air inlet. An inspiration valve is arranged at the position, at the medicine outlet, of the mist storage tank, the inspiration valve is located on the side, close to the mask body, in the medicine outlet, the medicine outlet is covered with the inspiration valve, and the inspiration valve has the capacity of deforming towards the direction away from the medicine outlet. By means of the structure, medicine mist can be stored in the mist storage tank in advance and fully mixed with air in the tank, when a patient inhales, the inspiration valve can be opened, the medicine mist can enter the mask body and be directly inhaled into an airway and lung tissue, the medicine amount staying at the oropharynx is obviously reduced, and the curative effect can be obviously improved; and the stimulation effect of the medicine mist on the oropharynx can be greatly reduced.

The present disclosure relates to the use of cannabidiol (CBD) for the treatment of atonic seizures. In particular the CBD appears particularly effective in reducing atonic seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; Doose Syndrome; Aicardi syndrome; CDKL5 and Dup15q in comparison to other seizure types. The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).