241 results about "Blood disease" patented technology

The invention provides a nitrate medicament for inhibiting angiogenesis. The general formula (I) of the medicament is T-(B-M)t1, wherein t1 is 1 or 2, T-Ht1 is a steroidal compound, and T-H means that oxygen atoms of the T are connected with the H to form the hydroxyl connection, namely the O-H typed connection. The compound of the formula (I) can be synthesized by taking the steroidal compound T-Ht1 as a raw material, and can be used for preparing the medicaments of treating angiogenesis diseases of human or mammals, particularly the medicaments of treating the diseases such as tumors, ocular angiogenesis, malignant blood diseases, bronchial asthma, leukoaraiosis and the like.

Disclosed is a therapeutic method comprising administering a TIM-3 antibody to a subject who is suspected to be suffering from blood tumor and in whom TIM-3 has been expressed in a Lin(−)CD34(+)CD38(−) cell fraction of bone marrow or peripheral blood or a subject who has been received any treatment for blood tumor. Also disclosed is a composition for preventing or treating blood tumor, which comprises a TIM-3 antibody as an active ingredient. Conceived diseases include those diseases which can be treated through the binding or targeting of the TIM-3 antibody to blood tumor cells (AML cells, CML cells, MDS cells, ALL cells, CLL cells, multiple myeloma cells, etc.), helper T cell (e.g., Th1 cells, Th17 cells), and antigen-presenting cells (e.g., dendritic cells, monocytes, macrophages, and cells resembling to the aforementioned cells (hepatic stellate cells, osteoclasts, microglial cells, intraepidermal macrophages, dust cells (alveolar macrophages), etc)), all of which are capable of expressing TIM-3. The diseases for which the therapeutic use is to be examined include blood diseases in which the expression of TIM-3 is observed in bone marrow or peripheral blood, particularly blood tumor.

The present invention discloses an application of dihydromyricetin in preparation of medicine for preventing or curing angiocardiopathy. The animal tests show that the dihydromyricetin has the effect for resisting internal phlebothrombosis, can be used for effectively preventing angiocardiopathy due to thrombosis, for example cardiac disease and apoplexy. Said invention can be made into medicine or health-care product.

A Chinese medicine for preventing and treating cardiovascular and cerebrovascular, diseases and hematopathy, and decreasing viscosity, pressure, fat and sugar of blood is prepared from 13 Chinese-medicinal materials including red sage root, red peony root, peach kernel, safflower, etc.

The invention relates to an integrated blood purifier, pertaining to the technical field of medical instruments. The technical scheme adopted by the invention is characterized in that the integrated blood purifier comprises a main body of the blood purifier, in which a handle tank is arranged; a handle is arranged in the handle tank; the front side of the handle tank is provided with an alarm lamp protection cover, in which an alarm prompt lamp is arranged; the front side of the main body of the blood purifier is provided with an imaging groove, in which a data display screen is arranged; the right side of the data display screen is provided with a signal prompt lamp; the right side of the signal prompt lamp, the right side of which is provided with a sample clamp; and the lower side of the sample clamp is provided with a sample retaining groove. The integrated blood purifier has following beneficial effects: the integrated blood purifier has complete functions and is convenient to use; when blood purification treatment is carried out to a patient with a blood disease so that time and labor are saved; the integrated blood purifier is reasonable, convenient, safe, highly-efficient and hygienic; and favorable influence upon treatment and recovery of the patient with the blood disease is caused.

The present invention provides multi-tailed lipid compounds, and salts and stereoisomers thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, plasmid DNA, small molecule, protein, peptide). The present invention also provides methods, and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases (e.g., liver diseases), respiratory diseases (e.g., lung diseases), painful conditions, psychiatric disorders, metabolic disorders, and spleen diseases.

The invention discloses a gastrodia tuber and lotus root health-care beverage which is characterized by comprising the following substances in parts by weight: 0.5-3 parts of fresh gastrodia tuber juice, 80-90 parts of lotus root juice, 3-10 parts of red date juice, 0.5-3 parts of salvia miltiorrhiza bunge, 0.5-8 parts of xylitol, 0.1-5 parts of citric acid and 0.02-0.05 part of essence. The gastrodia tuber and lotus root health-care beverage has the advantages of low cost, simple production process, favorable mouthfeeling and reasonable formula and is convenient to drink; in addition, the gastrodia tuber and lotus root health-care beverage has the efficacies of promoting the blood circulation and removing the blood stasis, suppressing hyperactive liver and tonifying qi, nourishing blood and promoting body fluid, calming the nerves and easing pain, clearing pathogenic heat and nurturing lung, strengthening the spleen and stimulating the appetite, relieving diarrhea and consolidating essence, tonifying the blood and replenishing the marrow, promoting mentality and strengthening the brain and promoting longevity, has a certain treatment effect on hypertension and cardio-cerebral blood disease, integrates the nutrition with the drink therapy health care and has large market potential.

The invention discloses a Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and a preparation process of products thereof. The preparation process comprises the following steps of: decocting Chinese angelica, chuanxiong rhizome, safflower, salvia miltiorrhiza, American ginseng, notoginseng, tree peony bark, earthworms, leech and gradfly; filtering; adding Zygosaccharomyces bailii to the resulting filtrate and filter residues, standing to culture in appropriate temperature and humidity environments for 168 to 240 hours, and making oral liquids, oral tablets or capsules. The main indications of the product disclosed by the invention include cardiovascular and cerebrovascular diseases, hypertension and blood diseases, and the product is directly taken, has rapid onset of action, prevents the recurrence of diseases, is absorbed rapidly, has high curative effects, is sweet in taste, and cause no sequela or complication after administration. By applying microorganisms to Chinese medicines, the two special processes of solid fermentation and liquid fermentation are achieved, so as to eliminate the toxic and adverse effects of active pharmaceutical ingredients, provide convenience for storage and administration and not produce wastes or residues. Besides, the resources of raw materials are abundant, the production is simple and low in cost, and the product is applied to both therapy and health care.

A method for modulating at least one pharmacokinetic property of an anti-angiogenic or blood disease or steroid therapeutic and efficacy upon administration to a host is provided. One administers to the host an effective amount of a bifunctional compound of less than about 5000 Daltons comprising the anti-angiogenic or blood disease or steroid therapeutic or an active derivative thereof and a pharmacokinetic modulating moiety. The pharmacokinetic modulating moiety binds to at least one intracellular protein. The bifunctional compound has at least one modulated pharmacokinetic property upon administration to the host as compared to a free drug control that comprises the anticancer therapeutic as well as enhanced efficacy not due to compound degradation. It is preferred that the pharmacokinetic modulating moiety has a mass of less than 1100 Daltons.

This invention relates to compounds, compositions, and methods useful for modulating associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of associated binding protein (GAB2) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GAB2 genes. The small nucleic acid molecules are useful in the treatment of cancer, malignant blood disease (leukemia), inflammatory diseases or conditions, allergic diseases or conditions, or proliferative diseases or conditions.

The invention is a medicine for curing arthrolithiasis and the preparing method thereof, characterized by that it is prepared of White Paeony Root, Fenbixian, Mulberry Twig, Herba Siegesbeckiae, Coix Seed, Glabrous Greenbrier Rhizome, Medicinal Cyathula Root, Clematis Root, and Membranous Milkvetch Root in certain proportion and able to be made into any oral form. It has functions of clearing heat and discharging corruption, tonifying spleen and promoting diuresis, and dispelling the wind and removing rheumatism and is used for curing diseases caused by damp, heat, accumulation and mass, especially pains in limbs, muscles and veins, red and swelling, fever and pains of joint, and inconvenient bending and extending. The curative effect study verifies that it can reduce the uric acid content of the blood serum of an animal with high- uric acid content blood disease, improve rheological indexes of the blood, and treat gouty arthritis and common inflammation and has good pain-stopping function and very curative effect on acute and chronic grouts, where the clinical effective rate is up to 91.36%.

The present invention relates to a plastic embedding medium for biological tissue section. It is made up by adopting glycol-acrylic esters compound and alcoholes organic solvent compound through a certain preparation process, and can be used for preparing the section at 4 deg.C-20 deg.C. The said section can be used for clearly observing cell structure and iron-stored condition of cell. This invention is convenient for taking material, simple in operation; when it is used for embedding biological tissue, it does not produce heat quantity, and does not damage or screen cell portion and nucleic acid, and the said section can be directly used to make enzyme immunoassay so as to improve the "gold standard" of "smear+ section +immunohistochemistry" for diagnosis of blood diseases.

The invention relates to a medicament for curing coronary heart diseases. The medicament is a preparation which comprises the following crude drugs by the weight part: 8 to 16 parts of Chinese angelica root, 9 to 19 parts of hoantchy root, 9 to 18 parts of ligusticum wallichii, 9 to 18 parts of red-rooted salvia root, 8 to 16 parts of Chinese thorowax root, 9 to 18 parts of glossy privet fruit, 9 to 18 parts of scrophulariaceae canaria, 9 to 18 parts of eucommia bark, 3 to 6 parts of aloe and 4 to 8 parts of antifebrile dichroa. The formula of the medicament focuses on the regulation of kidney functions, and at the same time, attaches importance to the coordination of functions of internal organs, such as the kidney, the heart, the liver, the spleen, etc. The medicament can not only reduce blood lipid, resist coagulation, reduce blood viscidity and dissolve internal clot, but also improve the functions of blood vessel endothelium. Furthermore, the medicament can remove vasospasm, resist arteriosclerosis and stabilize vulnerable plaque, and have double curative effects on blood diseases and vascular diseases, thereby effectively curing the cardiovascular system diseases.