202 results about "Blood product" patented technology

The invention belongs to the field of blood product separation, and discloses a high-efficiency chromatography system and method for blood product separation, and the system comprises an intelligent chromatography column module, an automatic sample injection and accurate flow rate control module, a chromatography filler and column design module, a real-time detection and data analysis module, and an intelligent automatic control and management module. By designing an efficient micro-nano filler chromatographic column and matching with a pulsed electric field auxiliary technology and intelligent automatic control, efficient and high-purity separation and purification of target blood product components are realized. The intelligent regulation and control module used in the invention can dynamically regulate chromatography conditions in real time, and the problems of unstable flow velocity and column pressure in the traditional method are thoroughly solved. And meanwhile, a multi-point real-time detection and feedback technology is adopted, so that the separation process is more accurate, transparent and controllable.

The invention discloses a block chain-based blood full-process traceability tracking and safety management system and method, and relates to the technical field of blood management, and the method comprises the steps: distributing an encrypted digital identifier with a timestamp for each blood unit; collecting physical characteristic data of the blood storage environment in real time; dynamically adjusting the state mark of the blood product based on a preset plasma quality evaluation model; a threshold signature technology is adopted to ensure that multiple medical institutions complete blood information verification and sharing on the premise of protecting privacy; when it is monitored that the blood environment parameters exceed a safety threshold value, graded early warning is generated, and an emergency processing flow is started; and establishing a blood circulation whole process auditing tracking system. The system has the advantages that the blood whole-process traceability system based on the block chain is constructed, transparent credible management of the whole life cycle of blood products from collection to use is achieved, the trust and privacy protection problem in multi-mechanism cooperation is solved, and the blood safety management level and the emergency processing efficiency are comprehensively improved.

The invention belongs to the technical field of medical treatment, and discloses a blood product virus inactivation system based on a synergistic effect of nano-catalysis photochemical inactivation and low-temperature plasma, the system comprises: a nano-photocatalysis inactivation module adopting titanium dioxide TiO2 and graphite phase carbon nitride g-C3N4 nano-materials as photocatalysts; the low-temperature plasma inactivation module adopts a low-temperature plasma generator to generate plasma cloud above the blood product and release active particles; the dynamic fluid stirring module is used for enabling the blood product to uniformly receive photocatalysis and plasma inactivation effects through a microfluid mixing technology so as to ensure the uniformity of virus inactivation; the sensing monitoring and intelligent feedback module is used for monitoring the residual quantity of viral nucleic acid and the activity of protein in the blood in real time by adopting a spectrum sensor and a biochemical sensor. The method can be widely applied to the fields of clinical blood transfusion, blood product manufacturing, blood disease treatment and the like, promotes the progress of a blood safety guarantee technology, reduces the virus infection risk and improves the patient safety.

The invention relates to the technical field of information management, in particular to a blood collection and supply informatization management system which comprises a blood collection data analysis module, a blood use and allocation module, a blood demand trend analysis module and an inventory assessment and scheduling module. By recording and analyzing the blood collection information, counting the blood collection amount and calculating the daily average collection amount, the blood center can accurately grasp the dynamic change of the blood resources, then the future supply and demand relation is predicted, the blood resources can be more reasonably configured, and by analyzing the blood use request, the blood resource utilization rate is improved. According to the invention, accurate blood blending is realized, effective utilization of blood is ensured, waste is reduced, inventory evaluation and scheduling optimization are carried out according to daily average data of usage amount and future prediction, turnover rate of blood products is increased, excess or shortage is avoided, smooth proceeding of medical activities is ensured, response speed of the system is enhanced, and the system is suitable for popularization and application. And the overall medical service quality and the patient safety are improved.

The invention belongs to the technical field of medical treatment, and discloses a preparation process for accurately regulating and controlling the component proportion of a blood product. The process comprises the following steps: blood collection and pretreatment; blood components are accurately separated; performing real-time component detection; intelligent regulation and control and closed-loop feedback are realized; and optimizing a finished product and monitoring quality. According to the preparation process capable of accurately regulating and controlling the component proportion of the blood product, by integrating AI intelligent control, microfluid separation, real-time sensor detection, dynamic feedback regulation and control and other technologies, high-precision, automatic and intelligent blending of blood components is achieved. The AI intelligent optimization algorithm is adopted, the composition proportion is dynamically adjusted, and the precision error of a finished product is reduced to be within + / -1% from traditional + / -5%. Intelligent feedback closed-loop control avoids deviation caused by human intervention, and the consistency is improved. In the traditional centrifugal separation, parameters need to be manually adjusted, and the separation efficiency is low, while the micro-fluid centrifugal technology is adopted in the method, efficient separation can be completed within 5-10 minutes, and the overall productivity is improved by 30%-50%.

The present invention relates to a system 1 for the digitalized management of blood products, in particular blood bags, throughout the entire transfusion process from blood donation to transfusion based on RFID technology.The RFID system 1 according to the invention comprises a data processing device 2 with a software product 9, which is connected via a LAN network 3 to an RFID printer 5, an RFID refrigerator 7, one or more RFID readers 8, 10, 24 for capturing and storing characteristic blood data in one or more RFID transponders 14, which are arranged and attached in the form of an RFID inlay 29 on the RFID label 15 of an RFID blood bag 6, wherein the software product 9 of the data processing device 2 controls the communication and data exchange via the LAN network 3 or a WLAN connection 4 with the connected RFID terminals and testing devices 5, 6, 8, 10-12 and carries out the data processing, as well as organizes the data exchange with a central information system for blood bag management 20. RFID transponders 14 are designed to transmit and receive UHF and HF signals and allow data exchange with NFC-enabled readers.Furthermore, a novel RFID label tester 18 for scanning and checking RFID labels 15 on RFID blood bags 6 as well as the barcodes on the blood bag by means of a camera 21 is specified.

The utility model discloses a centralized cooling type blood product storage chamber. The storage chamber is sequentially provided with a plasma storage chamber, a centralized cooling chamber, an erythrocyte storage chamber and a platelet storage chamber. The air supply pipe is used for feeding air in the concentrated cooling chamber into the plasma storage chamber and is provided with an air door and a fan; the air return pipe is communicated with the concentrated cooling chamber and the plasma storage chamber and is provided with an air door; the air supply pipe is used for feeding air in the concentrated cooling chamber into the red blood cell storage chamber and is provided with an air door and a fan; the air return pipe is communicated with the concentrated cold supply chamber and the red blood cell storage chamber and is provided with an air door; the air supply pipe is used for feeding cold air in the concentrated cold supply chamber into the blood platelet storage chamber and is provided with an air door and a fan; and the air return pipe is communicated with the concentrated cold supply chamber and the blood platelet storage chamber and is provided with an air door. Various storage environments suitable for different blood products are provided through cold air circulation. Temperature control of the storage chambers is achieved by means of fan power and air door adjustment, and the working condition of the refrigerating unit is more stable.

The invention relates to the field of blood products, in particular to a preparation method of human activated C1 esterase. The preparation method comprises the following steps: carrying out contact adsorption on cryoprecipitate-removed human plasma and anion exchange resin, washing and eluting to obtain an eluent containing C1 proesterase, carrying out membrane filtration, and carrying out ultrafiltration desalination treatment; adding an anionic substance into the eluent, incubating in vitro to effectively activate the C1 esterase, and filtering by a membrane to obtain a feed liquid containing the activated C1 esterase; and carrying out purification treatment on the feed liquid to obtain the human activated C1 esterase, and carrying out cryopreservation. According to the method, an anion substance is introduced into an eluent system obtained through anion exchange, mild and effective activation of the C1 proesterase is achieved under the condition of not depending on foreign proteolytic enzyme, the risk of non-specific hydrolysis and self-cutting inactivation is remarkably reduced, good synergy is formed with a follow-up purification process, and the method is suitable for industrial production. The human activated C1 esterase product with relatively high activity and good stability is obtained.

The utility model relates to a blood product transfer trolley which comprises a walking device, a containing box and a main controller, six box plates of the containing box are made of materials capable of shielding signals, and a weighing sensor is installed between the bottom of the containing box and the top of the walking device. The RFID chip, the ultrahigh-frequency RFID radio frequency reader-writer, the controller and the display screen are adhered to the blood product packaging bag; the blood product packaging bag is stacked in the accommodating box, and the RFID chip stores weight data of the blood product; the ultrahigh frequency RFID radio frequency reader-writer is mounted in the accommodating box; the weighing sensor and the ultrahigh frequency RFID radio frequency reader-writer are both in communication connection with the controller. According to the utility model, batch data acquisition is realized, the reading accuracy is high, the number of articles is physically read in combination with the weighing sensor, double-line reading and mutual verification are realized, and the accuracy of data entry is ensured.

The present invention relates to the use of PEG-phospholipid molecules to selectively mask surface antigens on erythrocytes, thrombocytes and / or endothelial cells. Blood products treated with PEG-phospholipid molecules can thereby be infused into uncrossmatched or incompatible recipients with reduced risk of antibody binding to the surface antigens and agglutination. Correspondingly, organ transplants treated with PEG-phospholipid molecules can be transplanted into uncrossmatched or incompatible recipients with reduced risk of antibody binding and antibody-mediated rejection.

The invention discloses a multiple real-time fluorescent PCR (polymerase chain reaction) primer probe combination, a kit and a detection method for detecting four common animal-derived components in a blood product. The multiplex real-time fluorescent PCR detection system comprises four groups of primer probe combinations of ducks, chickens, pigs and geese aiming at cytochrome b genes, and the sequences of the four groups of primer probe combinations are sequentially shown as SEQ ID No.1-12. According to the present invention, by using the specificity of the target gene, the primer probe combination only performs specific amplification on the target gene segment of the respective species, and is not interfered by other species; the method has the advantages of high throughput, strong specificity, high sensitivity and the like, the detection limit can reach 0.01% (w / w), and the method is suitable for large-scale rapid detection of four common derived components of ducks, chickens, pigs and geese in blood products.

The application relates to the technical field of blood product processing equipment, and discloses a pig blood sausage processing device and a pig blood sausage processing technology, wherein the pig blood sausage processing device comprises a support frame, a conveying mechanism and a lifting mechanism, the conveying mechanism is used for driving a carrying mechanism to move, the carrying mechanism is used for carrying a blood sausage after sausage filling, and the lifting mechanism is used for lifting the blood sausage for airing, the lifting mechanism comprises a lifting frame, a lifting assembly and an extension assembly, the lifting frame is fixedly arranged on the side of the support frame, a plurality of lifting assemblies are slidingly arranged on the lifting frame, the lifting assembly is used for lifting the blood sausage, the extension assembly is connected with the lifting frame and the lifting assembly, and the extension assembly is used for enabling the plurality of lifting assemblies to move at a corresponding distance, so that the problem that the airing efficiency of the blood sausage is low and the sausage casing may be damaged by manual operation in the prior art is solved.

The present invention pertains to the field of medicine and relates to a bag used for the collection, storage and separation of blood derivatives. The present patent is designed to enable the collection and separation of blood components in a single bag, suitable for generating fractionated bags and blood sample aliquots. This practice eliminates the risk of contamination due to the transfer and / or exposure of the blood products. The invention relates to a bag (1) composed of two superimposed polymeric films (2) and (3) sealed along their perimeter, and provided at its two ends with connectors (4), (5), (6), and (7), and handles (8) and (9), respectively; the bag (1) comprises an hourglass-shaped narrowing (10), formed by two trapezoidal seams (11) and (12) arranged opposite each other; the narrowing (10) has a length of between 6 mm and 15 mm (preferably 10 cm), a width of between 2 cm and 6 cm (preferably 4 cm), and angles (α), (β), (γ), and (δ) of between 10° and 60° (preferably 20°), while two or more demarcation lines (13) and (14) are placed transversely on both faces, on the narrowed region (11).

The utility model relates to the technical field of packaging, in particular to a discharging structure of a blood product bagging production line, which comprises a rack, a linear conveying mechanism is arranged on the rack, a belt conveying mechanism is arranged on the linear conveying mechanism, and a storage bin is arranged on the front side of the rack; a preset angle is formed between the belt conveying mechanism and the conveying direction of the linear conveying mechanism, and the belt conveying mechanism is used for conveying the packaged blood products into the storage bin; through the belt conveying mechanism which forms the preset angle with the conveying direction of the linear conveying mechanism, the packaged blood products can be transferred into the storage bin located on the front side of the rack after being packaged, and workers can conveniently take bags from the front side of the rack; workers can place packaging bags and take packaged blood products from the front side of the rack, and the working efficiency of the workers is improved.

The utility model belongs to the technical field of medical instruments, and discloses a bone marrow blood cell filtering and collecting device which comprises a support, a collecting pipe, a net barrel and a blood product bag, the collecting pipe is detachably arranged on the support and is of a barrel-shaped structure with an opening in the top, a liquid outlet connector is arranged at the bottom of the collecting pipe and detachably connected with a liquid outlet pipe, and the liquid outlet pipe is connected with the net barrel. A liquid stopping clamp is arranged on the liquid outlet pipe; the net cylinder is of a cylindrical structure with a top opening, the net cylinder is arranged in the collecting pipe, the edge of the top opening of the net cylinder is provided with a connecting part, and the connecting part is detachably connected with the top opening of the collecting pipe; the blood product bag is detachably connected with the end, away from the liquid outlet connector, of the liquid outlet pipe. According to the bone marrow blood cell filtering and collecting device, impurities in bone marrow blood can be effectively filtered out, the purposes of separating bone marrow stem cells, reducing waste of the bone marrow blood cells and conveniently transferring the bone marrow blood cells into a blood product bag by an operator are achieved, and the quality of the collected bone marrow blood cells and the hematopoietic stem cell infusion effect are improved.

The utility model discloses a duck blood product sterilizing device, which belongs to the technical field of duck blood processing equipment, and comprises two sterilizing boxes which are distributed in parallel, a water pump is arranged between the two sterilizing boxes, the water pump is connected with the two sterilizing boxes through a pipeline assembly, and a trolley is arranged on the inner sides of the sterilizing boxes. A plurality of vertically-distributed placement frames are installed on the inner side of the trolley, a thermometer is installed on the top of the sterilization box, a sealing cover is fixedly connected to the front face of the sterilization box through bolts, and an electric heater is arranged on the inner wall of the sterilization box. Through the arrangement of the water pump and the two sterilization boxes, the water pump can transfer high-temperature sterilization water on the inner sides of the two sterilization boxes through the pipeline assembly, when one sterilization box is used for sterilization, duck blood products are placed in the other sterilization box, and after sterilization is completed, the high-temperature sterilization water can be quickly transferred into the other sterilization box; and meanwhile, the working efficiency can be improved.

The invention relates to the technical field of medical logistics, and discloses an intelligent blood sampling robot system based on spatial positioning, which comprises a robot body, a central controller, a spatial positioning module, a dynamic environment modeling module, a motion control module, a transportation path planning module and a man-machine interaction module. According to the invention, the flight traffic mode is combined with the optimal path flight, the limitation of ground traffic congestion is eliminated, the transportation time is shortened, and in the path planning, the task continuity in a complex environment is ensured based on the synchronous positioning and map construction algorithm and the ultra wide band wireless carrier technology and in combination with the three-dimensional space coordinate sequence and the dynamic path adjustment, and the path planning efficiency is improved. The method has high dynamic response adjustment capability and timeliness, and a high-timeliness and high-safety intelligent solution is provided for emergency blood transfusion, cross-regional blood product blending and other scenes.

The present application relates to a full-process blood preparation control method and system, and relates to the field of blood products. The method includes obtaining the identity of each bag of blood material and the current link, determining the container and monitoring component required for the current link, and controlling the marking device to add the identity on the container, controlling the manipulator to add the monitoring component on the container, determining the correspondence between the monitoring component and the identity, obtaining the monitoring data collected by the monitoring component, and determining the preparation quality of the current link and the preparation interval quality after the current link is completed based on the monitoring data, and determining the overall preparation quality of each bag of blood material based on the preparation quality of each link and the preparation interval quality between two adjacent links. The present application improves the effect of overall preparation quality monitoring and accurately knows the preparation quality of the overall preparation process.

Method and systems for sorting potential hematopoietic stem cell transplant (HSCT) donors as a donor or non-donor using immunophenotyping of blood samples. The methods and systems can be used to identify a donor for a HSCT or to choose a donor to generate a HSCT blood product that is not likely to result in bad outcomes for a recipient. Also provided herein are methods and systems for training machine learning models that can be used in methods and systems for sorting potential HSCT donors.

The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method. The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient. The present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above.

The utility model discloses a blood low-temperature intelligent storage system which comprises a storeroom, a warehouse-in and warehouse-out operation table, a warehouse-in and warehouse-out temporary storage conveying line, a goods shelf unit and a traveling robot, a control system and a refrigerating system are integrated in the storeroom, a warehouse-in and warehouse-out automatic door is arranged on one side of the storeroom, and a heat insulation room matched with the warehouse-in and warehouse-out automatic door is arranged in the storeroom. A transmission mechanism for transmitting a blood frame is arranged in the thermal insulation room; the warehouse-in and warehouse-out operation table is arranged outside the warehouse and matched with the warehouse-in and warehouse-out automatic door, and the warehouse-in and warehouse-out operation table is used for manually operating warehouse-in and warehouse-out of the blood frames; the warehouse-in and warehouse-out temporary storage conveying line is arranged in the warehouse and is matched with the conveying mechanism; the goods shelf unit is arranged in the storeroom, the goods shelf unit is used for placing blood boxes, and a sorting robot is arranged in the goods shelf unit; and the travelling robot is arranged in the storehouse. The blood low-temperature intelligent storage system provided by the embodiment of the utility model can realize automatic warehouse-in and warehouse-out management of blood products.

The invention relates to the technical field of blood sampling centrifugal tubes, and discloses a vacuum blood sampling centrifugal tube which comprises an outer tube, an inner tube, an extraction opening, an insertion hole block, an upper tube cap and a lower tube cap. Through the structural design of the extraction opening in the side wall, the breakthrough closed layered liquid extraction technology is achieved, the extraction opening is directly communicated with the inner pipe to form a closed liquid extraction channel, and therefore an operator can complete flat layer extraction of a target component layer in a completely closed environment without opening an upper pipe cap; air contact pollution caused by traditional uncovering liquid taking is fundamentally eradicated; meanwhile, the extraction opening preset at the height of the target liquid layer can be directly aligned with the required components for precise extraction, so that component mixing caused by the fact that a puncture needle penetrates through the upper-layer liquid is completely avoided, it is ensured that the target component with the highest purity is obtained, the whole liquid extraction process is completed in a completely-closed pipeline system, and the extraction efficiency is improved. The biological safety and component integrity of blood products are guaranteed, and high-yield extraction of target components can be achieved.

The present disclosure is directed to methods for scrubbing low levels of urea from aqueous solutions such as a dialysate from dialysis, and including blood and blood products, and devices capable of employing these methods.

The invention discloses a blood coagulation index detection system and method based on ultrasonic guided waves, and the method comprises the steps: calculating a blood coagulation index corresponding to a sample according to an obtained viscoelasticity change curve; comprising the following steps: the clot starting time is defined as the time interval from the time when a blood sample is placed in a blood clot index detection system to the time when initial fibrin starts to form, and the R time of a TEG detection result of a gold standard method is marked; the clot stabilization time is defined as the clot formation time of the blood sample and the K time of the TEG detection result of the gold standard method; the theta angle is used for measuring the generation and cross-linking speed of fibrin and the alpha angle of a TEG detection result of a gold standard method; the maximum clot strength is the MA value of the TEG detection result of the gold standard method. Compared with a TEG method, the method has the advantages that the detection time of blood coagulation indexes is remarkably shortened, time guarantee is provided for emergency blood coagulation function evaluation and reasonable application of blood products in an operation, and improvement of clinical prognosis is facilitated.

Provided is a technique for preparing universal DNT cells. The raw materials for preparation are derived from'white filtering residues' after white filtering treatment is carried out to avoid blood transfusion adverse reactions, and the DNT cells extracted from the white filtering residues can be a mixed culture of one or more healthy donors. The universal DNT cell obtained by using the method provided by the invention has the characteristics of high yield, high purity, high in-vitro tumor killing activity, suitability for large-scale production and the like. The initial raw material can be fresh cells or re-thawed cells after cryopreservation, the raw material source bottleneck of large-scale preparation of cell drugs is fundamentally solved, the value of leukocytes filtered out in the production process of blood products is re-excavated, and great medical value and commercial application prospects are achieved.

Methods of preparing therapeutic blood products from merged plasma donors are described. Therapeutic blood products include, for example, plasma, plasma proteins, and plasma fractions with improved safety by reducing the concentration of donor autoantibodies against Fc [epsilon] RI [beta] or eliminating such antibodies.

The present application relates to the technical field of medical supplies transfer, and discloses a method for controlling a transfer vehicle, including: detecting the temperature inside each transfer box; determining a transfer box with an internal temperature greater than a first preset temperature as a target transfer box; controlling the movement of the transfer storage device until the shelf where the target transfer box is located moves to the air outlet, so as to reduce the internal temperature of the target transfer box. During the transportation process of the transfer vehicle, the present application can automatically move the shelf where the transfer box with poor refrigeration effect is located to the vicinity of the refrigeration system by controlling the reasonable movement of the transfer storage device, so as to facilitate more sufficient cooling of these transfer boxes. This can reduce the possibility of deterioration and damage of blood products, which is beneficial to improving the reliability of the transportation process. The present application also discloses a device for controlling a transfer vehicle, a transfer vehicle, and a storage medium.

The invention discloses a primer combination for detecting Ralstonia pickettii and a kit for detecting the Ralstonia pickettii, wherein the kit comprises the primer combination. The primer probe provided by the invention is targeted to a specific nucleotide sequence of the Ralstonia piceatrii instead of a horizontal conserved sequence, so that the Ralstonia piceatrii and other strains in the Ralstonia can be effectively distinguished, the technical defects that an existing detection method is insufficient in specificity and easy to generate false positive are overcome, and the accuracy of a detection result is improved. The detection limit can reach 100 CFU / mL, and compared with the prior art, the detection limit is reduced, and the detection sensitivity is improved. The kit disclosed by the invention can be applied to pollution detection of medical supplies such as pharmaceutical water, dialysis water, endoscope cleaning water, blood products, sterile normal saline and the like and rapid screening of hospital infection, is strong in specificity and high in accuracy, and has relatively high popularization and application values.

The invention relates to a freeze drying method of instant fibrinogen, and belongs to the technical field of blood product preparation. The method comprises the steps of plasma pre-fusion, centrifugal separation, FI extraction, FI precipitation, dissolution and filtration, polyethylene glycol purification and separation, S / D inactivation, ethanol purification and separation, glycine purification and separation, ultrafiltration dialysis, preparation, degerming and subpackaging, freeze-drying and capping and the like. Wherein the freeze-drying process comprises four stages of pre-freezing, primary sublimation, desorption drying and plug pressing, and finally dry heat inactivation treatment is carried out. According to the method, efficient extraction and purification of fibrinogen are achieved by accurately controlling the temperature, the time, the pH value and the component proportion of various solutions in each step, and the obtained product has good instant dissolving performance and can be used in the medical fields of clinical hemostasis, tissue repair and the like.