4319results about "Solid sorbent liquid separation" patented technology

A process for upgrading a plastic derived oil includes providing the plastic derived oil comprising hydrocarbons and greater than or equal to 100 ppmw halogen-containing compounds and contacting the plastic derived oil with an MMO catalyst in a first reactor at reaction conditions to remove halogens from the plastic derived oil to produce a first reactor effluent with less than 100 ppmw halogen-containing compounds. The process includes contacting the first reactor effluent with an adsorbent to produce a treated first reactor effluent, passing the treated first reactor effluent to a second reactor, and contacting the treated first reactor effluent with a cracking catalyst in the second reactor. Contacting with the cracking catalyst may cause hydrocarbons in the treated first reactor effluent to undergo catalytic cracking to produce a second reactor effluent comprising light olefins, naphtha range hydrocarbons, or combinations thereof.

The invention belongs to the field of blood product separation, and discloses a high-efficiency chromatography system and method for blood product separation, and the system comprises an intelligent chromatography column module, an automatic sample injection and accurate flow rate control module, a chromatography filler and column design module, a real-time detection and data analysis module, and an intelligent automatic control and management module. By designing an efficient micro-nano filler chromatographic column and matching with a pulsed electric field auxiliary technology and intelligent automatic control, efficient and high-purity separation and purification of target blood product components are realized. The intelligent regulation and control module used in the invention can dynamically regulate chromatography conditions in real time, and the problems of unstable flow velocity and column pressure in the traditional method are thoroughly solved. And meanwhile, a multi-point real-time detection and feedback technology is adopted, so that the separation process is more accurate, transparent and controllable.

The invention provides a therapeutic drug monitoring kit and method and system, a magnetic bead extraction method is combined with LC-MS / MS detection to be applied to human blood drug concentration monitoring, a mixed magnetic bead solution containing phospholipid removal magnetic beads and to-be-detected drug adsorption magnetic beads is utilized to perform adsorption and extraction pretreatment on a to-be-detected drug in a sample, automatic treatment equipment is matched, and the concentration of the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug is detected. The pretreatment efficiency is high, the phospholipid content in the supernate is low, and the matrix effect and the chromatographic column washing pressure are greatly reduced. According to the therapeutic drug monitoring method provided by the invention, a unified pretreatment process is used, simultaneous extraction of multiple drugs is realized, and through a magnetic bead automatic extraction method, the pretreatment step of a sample can be rapidly completed, a therapeutic drug monitoring result can be rapidly obtained, the overall detection time is shortened, and the detection efficiency is improved. Therefore, a reliable laboratory examination basis is provided for individualized treatment.

An exosome extraction device, comprising: a base (4); a filter column placement disc (1), wherein the filter column placement disc (1) comprises a placement disc body (11), a plurality of extraction column placement holes (111) are formed in the placement disc body (11), the extraction column placement holes (111) are used for placement of exosome extraction columns (100), and the placement disc body (11) can be rotatably mounted on the base (4) relative to the base (4); an exosome collection disc (2), wherein the exosome collection disc (2) comprises a collection disc body (21), a plurality of collection tube placement holes (211) are formed in the collection disc body (21), the collection tube placement holes (211) are used for placement of exosome collection tubes (200), and the collection disc body (21) is rotatably mounted on the base (4) relative to the base (4); and a collection disc translation mechanism for driving the collection disc body (21) to move to a position below the placement disc body (11) or move away from the position below the placement disc body (11), wherein in the state where the collection disc body (21) is located below the collection disc body (11), the placement disc body (11) and the collection disc body (21) rotate, so that the collection tube placement holes (211) can be aligned with the extraction column placement holes (111) so as to collect exosomes dripping from the exosome extraction columns (100).

The application discloses a chromatography material raw material composition, a chromatography material and a preparation method and application thereof, a whole column and a chromatography pile. The chromatography material raw material composition, with the total weight of raw material A and pore former B being 100%, comprises the following components: 20%-70% of raw material A; 30%-80% of pore former B; 0.1 ‰-1 ‰ of catalyst C; and the raw material A comprises a substance containing a polycyclic epoxy group. The chromatography material composition of the application can solve the pain points of the application of the current chromatography microsphere filler on biological macromolecules. The chromatography material has the advantages of uniform internal structure, good preparation reproducibility, high toughness, modifiable functional ligand and high hydrophilicity, and is more suitable for the separation and purification of biological molecules.

The utility model belongs to the technical field of sugar alcohol preparation, and relates to a system for co-producing L-arabinose and caramel pigment by using xylose chromatography raffinate, which comprises a raw material tank, a nanofiltration membrane separator, a chromatography separation device, an evaporation concentration tank, a crystallization tank, a centrifugal separator and a dryer which are sequentially communicated by pipelines, and the browning reaction assembly is used for mixing the raffinate and the centrifugal mother liquor and then carrying out browning reaction treatment to prepare caramel pigment. The chromatographic separation device is used for separating an extracting solution and raffinate from the flowing nanofiltration permeate, the evaporation concentration tank and the crystallizing tank are used for concentrating and crystallizing the flowing extracting solution into massecuite, the centrifugal separator is used for separating the flowing massecuite into moist sugar and centrifugal mother liquor, and the dryer is used for drying the flowing moist sugar into L-arabinose crystals. According to the utility model, raffinate and centrifugal mother liquor are mixed to prepare a caramel pigment liquid product, so that a caramel pigment additional product is obtained while the utilization rate of saccharide resources is improved.

The invention discloses a method for green and efficient removal of thiophene sulfides in fuel oil by using Q [8]. According to the method provided by the invention, a Q [8] solid powder material is adopted to carry out removal treatment on simulated fuel oil containing the thiophene sulfides in a subject-object interaction mode, and the Q [8] solid powder material can be subjected to a regeneration process for reuse through ethanol desorption. The Q [8] solid powder material used in the method is low in cost, the urea is a main raw material for synthesis of the Q [8] solid powder material, and the Q [8] solid powder material is high in selectivity, can be recycled and is more environmentally friendly. The method is simple to operate, convenient to use and low in cost, the combustion simulation oil can be efficiently desulfurized, and environmental pollution is effectively reduced.

The invention provides a method for preparing high-purity phosphatidylserine by a batch enzyme catalysis method based on dynamic choline removal, and belongs to the technical field of enzymatic reaction. According to the method disclosed by the invention, in a reaction system for preparing phosphatidylserine, a byproduct choline is selectively adsorbed by adopting resin. Choline in a reaction system is removed in real time through the integrated adsorption separation module, the enzyme inhibition problem is solved, and meanwhile, the PC conversion rate is larger than or equal to 98% and the PS purity is larger than or equal to 96% in combination with the immobilized enzyme circulation technology; the enzyme can be reused for more than or equal to 20 times (activity retention is more than or equal to 90%); and the choline residual concentration is less than or equal to 0.5 mM (an inhibition threshold value or less).

The invention belongs to the technical field of chromatographic packing, and particularly relates to a double-layer hole type SiO2 (at) SiO2 core-shell microsphere based on a double-phase method and a preparation method and application of the double-layer hole type SiO2 (at) SiO2 core-shell microsphere. According to the core-shell microsphere, micron-sized non-porous SiO2 serves as a core, a mesoporous SiO2 framework with pore channels perpendicular to the surface of the non-porous SiO2 core serves as a porous shell layer, the porous shell layer sequentially comprises a first ordered mesoporous shell layer and a second ordered mesoporous shell layer which are different in pore diameter from inside to outside, and the pore channels of the two shell layers are completely consistent in direction and are communicated with each other. According to the invention, a porous shell structure with dual or multiple pore size distribution is constructed on the surface of a SiO2 core, and by integrating more than two pore sizes with obvious size difference, exclusive mass transfer paths are provided for solute molecules with different sizes, exclusive mass transfer channels can be provided for small-molecular compounds and macromolecular substances at the same time, and the pore size difference is greatly reduced. Therefore, the selectivity and column efficiency of chromatographic separation are remarkably improved.

The present disclosure relates to the extraction of lithium from liquid resources such as natural and synthetic brines, leachate solutions from clays and minerals, and recycled products. Herein are systems and processes for extracting lithium using ion exchange materials, where transition metal impurities may be removed from the synthetic lithium solution. In some embodiments, the transition metal species are reformulated to form ion exchange materials to be used in the systems and processes described herein.

The invention provides an online monitoring device for multiple nuclides in liquid effluent, and particularly relates to the technical field of radioactive substance detection. The online monitoring device comprises a shell, a cascade separation module, a fluid control module, a detection module and a control system, the cascade separation module, the detection module and the control system are arranged in the shell, the cascade separation module comprises a plurality of resin columns and a plurality of separated liquid collecting bottles communicated with the resin columns, and the separated liquid collecting bottles are communicated with the resin columns. The fluid control module comprises a liquid storage device, an injection pump and a control valve, the liquid storage device is respectively communicated with the plurality of resin columns through pipelines, the injection pump and the control valve are respectively arranged on the pipelines and are used for controlling the flow direction and the flow velocity of fluid in the liquid storage device, and the detection module is used for detecting the radioactive activity of nuclide; the control system is used for controlling operation of the cascade separation module, the fluid control module and the detection module. According to the invention, synchronous monitoring of multiple nuclides is realized, the multi-nuclide monitoring efficiency is improved, and the monitoring cost is reduced.

The invention belongs to the technical field of chromatographic packing, and particularly relates to a double-layer stacking hole type SiO2-coated SiO2 core-shell microsphere as well as a preparation method and application thereof. The core-shell microsphere takes micron-sized non-porous SiO2 as a core and takes a SiO2 nanoparticle stacking layer as a porous shell layer, the porous shell layer sequentially comprises a first SiO2 mesoporous shell layer and a second SiO2 mesoporous shell layer from inside to outside, SiO2 nanoparticles in the first SiO2 mesoporous shell layer are stacked to form a first gap pore channel, and SiO2 nanoparticles in the second SiO2 mesoporous shell layer are stacked to form a second gap pore channel. According to the invention, a porous shell structure with dual or multiple pore size distribution is constructed on the surface of a SiO2 core, and by integrating more than two pore sizes with obvious size difference, exclusive mass transfer paths are provided for solute molecules with different sizes, exclusive mass transfer channels can be provided for small-molecular compounds and macromolecular substances at the same time, and the pore size difference is greatly reduced. Therefore, the selectivity and column efficiency of chromatographic separation are remarkably improved.

A method is provided, comprising: obtaining, for a chromatography machine including a first dispersed plug flow reactor (DPFR) and a continuous stirred tank reactor (CSTR) prior to a column, and a second DPFR after the column, geometric measurements associated with the second DPFR; generating, by a processor, transport model parameters for a transport model associated with the second DPFR based on the geometric measurements; feeding a tracer molecule into the chromatography machine; capturing one or more tracer molecule measurements based on the tracer molecule traveling through the chromatography machine; and estimating, by the processor, based on the transport model associated with the second DPFR and the one or more tracer molecule measurements based on the tracer molecule traveling through the chromatography machine, one or more transport model parameters for a transport model associated with the first DPFR and the CSTR.

The present invention provide novel immunofiber compositions for protein or peptide purification and simple and cost-efficient methods and systems using these compositions. In some embodiments, the immunofibers comprise a customized Z-33 peptide derived from Staphylococcus aureus Protein A which is used to construct immuno-amphiphile molecules that assemble into immunofibers in aqueous solution with bioactive epitopes on the surface and have peptide or protein binding ability.

An ion exchange filter (100) comprising: an outer housing (1) comprising a coolant inlet (2) and a coolant outlet (12); and an ion exchange device (11) configured to be disposed within the outer housing (1). The ion exchange device (11) comprises: an inner housing (5) configured to be inserted within the outer housing (1), the ion exchange filter (100) further comprising an inlet chamber (16) defined between a bottom portion of the inner housing (5) and a bottom portion of the outer housing (1); an ion exchange element (6) disposed within the inner housing (5) and configured to adsorb conductive ions in a coolant liquid; and an upper cover (10) removably connected to the inner housing (5) and to the outer housing (1), the ion exchange filter (100) further comprising an outlet chamber (73) defined between a top portion of the inner housing (5) and the ion exchange element (6).

The utility model provides automatic dry method sample loading equipment which comprises a workbench, a powder adding module, a rotary evaporation module, a powder scraping module and a carrying mechanism, the powder adding module, the rotary evaporation module, the powder scraping module and the carrying mechanism are arranged on the workbench, the powder adding module is used for adding needed powder into a sample container, and the sample container contains a sample; the rotary evaporation module is used for carrying out rotary evaporation on the sample added with the powder and the liquid in the sample container, so that the liquid sample and the powder sample are uniformly mixed and dried to form a powder sample; the powder scraping module is used for performing powder scraping operation on the sample container and scraping the powder sample from the inner surface of the sample container; one end of the carrying mechanism is rotationally connected with the workbench, the other end of the carrying mechanism is provided with a clamping device used for clamping materials and interaction tools, and the carrying mechanism is used for interacting among the powder adding module, the rotary evaporation module and the powder scraping module. The present disclosure also provides an automated sample processing system. According to the invention, the full-automatic unmanned process can be realized, the labor cost is reduced, and the efficiency and precision are improved.

The invention relates to a serum liquid chromatography-tandem mass spectrometry pretreatment method, which comprises: (S1) mixing a serum sample and a formic acid-containing acetonitrile solution, carrying out ultrasonic treatment, vortex oscillation and centrifugation, taking the supernatant, and diluting with a formic acid-containing aqueous solution to obtain a liquid to be purified; (S2) mixing the to-be-purified liquid with PCN-777, performing ultrasonic treatment, vortex oscillation and centrifugation, and taking supernate to obtain to-be-detected liquid; the PCN-777 is a C24H23N3O16Zr3 phospholipid removal material, and the PCN-777 is a C24H23N3O16Zr3 phospholipid removal material, and the PCN-777 is a C24H23N3O16Zr3 phospholipid removal material. According to the present invention, the serum ultra-high performance liquid chromatography-tandem mass spectrometry pretreatment method is developed by using the known MOFs material PCN-777, such that different types of phospholipids in the serum can be specifically, rapidly and effectively removed, the efficient recovery and detection of pesticide and veterinary drugs can be achieved, and the interference of phospholipids can be avoided.

A liquid immersion cooling system, that cools a heat generating body provided on a substrate, includes: a cooling device main body having a casing that houses the substrate and the heat generating body inside and stores a refrigerant for cooling the heat generating body; a circulation flow channel having both ends connected to each other in a communication state in the casing; an adsorption unit that is provided in the circulation flow channel and adsorbs impurities from the refrigerant circulating in the circulation flow channel; a pump that circulates the refrigerant in the circulation flow channel; and a control device that controls the pump. The control device includes a temperature drop detection unit that detects a decrease in temperature of the refrigerant in the casing, and a pump drive unit that drives the pump based on a detection of the temperature drop detection unit.

The invention discloses a human albumin binding peptide 1E3 and application of the human albumin binding peptide 1E3 in promoting purification of human albumin, and belongs to the technical field of polypeptides. The human albumin binding peptide comprises an amino acid sequence as shown in SEQ ID NO. 1; and / or an amino acid sequence of a fusion protein with the same function, which is obtained by connecting tag protein to the N terminal and / or C terminal of the amino acid sequence as shown in SEQ ID NO.1. The human albumin binding peptide has extremely high affinity with human albumin and can be used for separating and purifying a human albumin solution, and the purity of the purified human albumin far exceeds the pharmacopoeia standard and can reach 99.99% or above. The method is good in safety and stable in process, and has a wide application prospect in the aspect of separation and purification of the human albumin.

The invention provides a method for separating EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) through supercritical fluid chromatography, and relates to the technical field of separation and purification. The invention provides a method for separating EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) by supercritical fluid chromatography, which comprises the following steps: by taking supercritical carbon dioxide and an organic reagent as mobile phases, and by utilizing the specific mobile phase property of supercritical CO2 after being mixed with the organic reagent (saturated aliphatic hydrocarbon) and matching with a normal-phase chromatographic column, separating the EPA from the DHA by supercritical fluid chromatography. A specific stationary phase (one or more of a silica gel surface bonded propylurea stationary phase, a silica gel surface bonded phenyl stationary phase and a silica gel surface bonded imidazolyl stationary phase) is adopted, effective separation and preparation of the EPA and the DHA in the fish oil can be achieved, the EPA and the DHA in the fish oil can be effectively separated within 50 min, the separation speed is high, the separation effect is good, and the method is suitable for industrial production. The purity of the obtained EPA and DHA is 98% or above, the purity of the EPA and the DHA is high, and the EPA and the DHA have good application prospects in the fields of medicine production and food and health care products.

The present invention relates to a container (10) for extracting lithium or lithium salts from a brine with a brine inlet port (20) for receiving the brine arranged at a first portion of the container (10); a multiple-use port (30) arranged at a second portion of the container (10); a sorbent bed volume (40) for holding a sorbent material, arranged between the brine inlet port (20) and the multiple-use port (30); and a mixing chamber (50) arranged inside the container (10) between the brine inlet port (20) and the sorbent bed volume (40), for mixing the brine before entering the sorbent bed volume (40). The present invention further relates to a process for extracting lithium or lithium salts from the brine and to a process for extracting lithium or lithium salts from a loaded sorbent material and to a process for cleaning the container (10).

The invention provides a device and a method for detecting antibiotics in aquaculture water, and belongs to the technical field of environmental pollutant detection. According to the device disclosed by the invention, a Fe3O4 (at) GO magnetic nano adsorption material is packaged in a micro-fluidic chip reaction chamber, and a magnetic sticker is innovatively adopted to realize immobilization and replaceable design of an adsorbent; the integrated electromagnetic oscillation module drives the adsorbent to vibrate in the microchannel, and the mass transfer capture efficiency of antibiotics such as sulfonamides, quinolones and tetracyclines is remarkably improved. According to the method, an adsorption-elution-detection integrated process is initiated for the first time, the pretreatment time is shortened to be within 10 minutes from the hour level, synchronous detection of 0.01-5 [mu] g / L ultra-trace multi-component antibiotics in 5-10 [mu] L of a water sample is achieved, compared with a traditional method, the detection precision is remarkably improved, the matrix interference resistance is high, and the method is suitable for large-scale popularization and application. The method is suitable for real-time online monitoring of multiple antibiotic residues in the aquaculture environment.

The invention belongs to the technical field of organic matter extraction, and particularly relates to a green directional extraction and purification method for haematococcus astaxanthin, which comprises the following steps: (1) mixing dried haematococcus powder and a composite pretreatment agent according to a mass ratio of 1: (8-15), and stirring to obtain a pretreated algae solution; (2) treating the pretreated algae liquid through ultrahigh-pressure microjet equipment to obtain wall-broken slurry; (3) mixing the wall-broken slurry and a composite extraction agent according to a volume ratio of 1: 3-1: 5, and performing extraction separation to obtain an astaxanthin extraction phase; (4) carrying out selective adsorption on the astaxanthin extraction phase through an adsorption column filled with a molecular imprinting adsorbent; (5) collecting eluent by adopting a gradient elution method; and (6) performing vacuum concentration on the eluent, and performing spray drying to obtain an astaxanthin product. According to the method, the astaxanthin extraction efficiency and the product purity are remarkably improved, meanwhile, the energy consumption is reduced to the maximum extent, toxic solvent residues are avoided, and the stability of the astaxanthin is effectively protected.

The invention provides a method for separating and purifying galactose and glucose by using a simulated moving bed chromatography system, and relates to the technical field of saccharide separation and purification. According to the method, the simulated moving bed chromatography system is used for separating and purifying the galactose, operation can be carried out under the set temperature condition, the separation and purification efficiency of the galactose is remarkably improved, continuous large-scale efficient separation and purification of the galactose can be achieved, the separation and purification effect is good, the yield is high, and the product quality is good. According to the method, pure water is used as an eluent, and analyzed and purified compounds are free of damage, low in toxicity, rich in source and low in cost.

The present application relates to electrolytic manganese technology field, specifically to a kind of method for removing heavy metal ions in manganese sulfate solution.The method for removing heavy metal ions in manganese sulfate solution provided by the present application includes the following steps: adding oxidizing agent to pretreated manganese sulfate solution, mixing and stirring, then adjusting the pH value of solution to 5.5-6.0, filtering, to obtain the first purified manganese sulfate solution;Add sulfidation agent to the first purified manganese sulfate solution, filter, to obtain the second purified manganese sulfate solution;Add porous resin polymer to the second purified manganese sulfate solution, add the mixed solution into a sealed container, introduce nitrogen, make the pressure in the sealed container reach 1.1-1.5MPa and maintain for 2-10min, then open the air valve and release pressure instantaneously, stand, filter, fine filter, to obtain the purified manganese sulfate solution.The method provided by the present application can not only effectively remove heavy metal ions in solution, but also effectively reduce the COD value of the purified solution, reduce the loss of manganese content in solution.

The invention discloses an adsorption / desorption device for salt lake adsorption and lithium extraction and application thereof.The adsorption / desorption device for salt lake adsorption and lithium extraction comprises an adsorption and desorption column, an adsorbent containing area used for containing an adsorbent is arranged in the adsorption and desorption column, and a positive electrode and a negative electrode are oppositely arranged in the adsorbent containing area; the positive electrode and the negative electrode are connected through a direct-current power supply capable of reversing poles, a variable electric field can be formed during pole reversing, and the variable electric field can drive lithium ions to migrate and accelerate desorption of the lithium ions from an adsorbent, so that the lithium ion desorption efficiency is favorably improved, the concentration of the lithium ions in a desorption solution is higher, fresh water is saved, and the service life of the lithium ion battery is prolonged. And time and energy consumption are saved for subsequent concentration of lithium ions. The adsorption / desorption device for adsorbing and extracting lithium in the salt lake is simple in process flow and simple and convenient to operate, can effectively improve the desorption efficiency and save working hours, energy and fresh water, and has practical significance on utilization of lithium resources in the salt lake.

The invention discloses a method for extracting a target product from a milk raw material, and relates to the technical field of food processing. According to the method, before strong anion exchange chromatography is carried out, a synergistic pretreatment step of ultrafiltration and conductivity adjustment is introduced, so that acceleration, synergism, quality improvement and cost reduction of the chromatography process are realized, and the technical bottlenecks of low speed, easiness in pollution, instability and the like of the traditional ion exchange chromatography during treatment of milk raw materials are overcome; and a solution is provided for high-efficiency, high-purity and large-scale production of the beta-lactoglobulin and the alpha-lactalbumin. According to the method, strong anion exchange chromatography and weak anion exchange chromatography can be combined, so that the extraction purity of beta-lactoglobulin and alpha-lactalbumin can be further improved; in addition, the method can synchronously realize high-efficiency extraction of various target substances such as casein micelles, lactose and milk mineral salts, so that the additional value and resource utilization efficiency of milk source byproducts are greatly improved.

The utility model discloses a salt lake lithium extraction adsorbent scrubbing system which comprises a scrubbing tower and an adsorption tower, and a sunken water distributor is arranged at the bottom end in the scrubbing tower; the middle position of the bottom of the concave water distributor penetrates through the bottom of the scrubbing tower and is connected with a runner opening; a water replenishing opening is formed in the middle of the bottom of the scrubbing tower; two feed ports are formed in the positions, close to the water inlet, of one side of the scrubbing tower, and a water outlet is formed in the position, close to the top, of one side of the scrubbing tower; the flow channel port is sequentially connected with a pneumatic valve j, a diaphragm pump B and an adsorption column through a pipeline; according to the system, crushed resin particles and impurities are effectively removed by cleaning an adsorbent, so that the adsorption performance and the flowability of a resin bed layer are recovered, and it is ensured that the resin bed layer is always in the optimal working state. In the process of scrubbing the adsorbent, the adsorbent does not need to be manually carried except for necessary adsorption tower pipeline connection operation, so that the scrubbing efficiency is remarkably improved.

Targetry coupled separation refers to enhancing the production of a predetermined radiation product through the selection of a target (including selection of the target material and the material's physical structure) and separation chemistry in order to optimize the recovery of the predetermined radiation product. This disclosure describes systems and methods for creating (through irradiation) and removing one or more desired radioisotopes from a target and further describes systems and methods that allow the same target to undergo multiple irradiations and separation operations without damage to the target. In contrast with the prior art that requires complete dissolution or destruction of a target before recovery of any irradiation products, the repeated reuse of the same physical target allowed by targetry coupled separation represents a significant increase in efficiency and decrease in cost over the prior art.

The utility model discloses a dynamic axial compression column, and relates to the field of compression columns. The dynamic axial compression column comprises a heat preservation jacket, a piston plate, a support and a measuring rod, the heat preservation jacket is provided with a compression cavity with an opening in the upper end, and the heat preservation jacket is provided with an interlayer arranged around the compression cavity; the measuring rod and the support are slidably arranged. Circulating liquid for heat exchange circulates through the first inlet, the interlayer and the first outlet on the heat preservation jacket, so that filler in the compression cavity is stabilized at an expected temperature, and the consistency of filler column efficiency is ensured; the piston plate axially compresses the filler, the measuring rod correspondingly moves along with the piston plate, the filling height is correspondingly measured according to the movement of the measuring rod, column filling is stopped when the required length is reached, and it is guaranteed that the filling heights of the materials are the same and consistent every time, so that the column efficiency is accurately calculated; according to the utility model, the use requirements of filler filling height measurement and filler temperature control can be met, and the column efficiency and the column temperature are easier to control.