29results about How to "High rate" patented technology

Provided in the present invention are a class of compounds as represented by formula (I), or a prodrug, a tautomer, a stereoisomer, a solvate, and an isotopic derivative thereof, or a pharmaceutically acceptable salt thereof. The compound has an SHP2 kinase inhibitory effect and can be used for treating and / or preventing diseases, disorders, and conditions mediated by SHP2 activity, such as tumors, cancers, cancer metastasis, cardiovascular diseases, immune disorders, visual disorders, etc.

The present invention comprises: a first tray for forming a portion of an ice-making cell; a second tray forming the other portion of the ice-making cell, and capable of moving relative to the first tray; an ice bin for storing ice separated from the first and second trays; and a full-ice sensing lever for moving together with the second tray in a predetermined range.

The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,

Provided is a photochromic compound represented by the following General Formula 1. In General Formula 1, Az represents a monovalent azine ring group which is unsubstituted or has a substituent, L represents a divalent or higher linking group, D represents a photochromic dye structure, a and c each independently represent an integer of 1 or more, b represents 0 or an integer of 1 or more; and when there are a plurality of Az's in General Formula 1, the plurality of Az's may be the same as or different from each other, and when there are a plurality of L's in General Formula 1, the plurality of L's may be the same as or different from each other.

A single-crystal-type multi-element positive electrode material, and a preparation method therefor and an application thereof. The positive electrode material satisfies the following conditions: single crystal sizes DPS90, DPS10 and DPS50 of the positive electrode material, which are measured by means of SEM, satisfying the following relationship: 0.1≤B90=(DPS90-DPS10) / DPS50≤1.5; and the agglomeration rate of the positive electrode material being less than or equal to 20%, wherein DPS90 represents that 90% of the single crystal size of the positive electrode material is less than DPS90, DPS50 represents that 50% of the single crystal size of the positive electrode material is less than DPS50, and DPS10 represents that 10% of the single crystal size of the positive electrode material is less than DPS10. The single-crystal-type multi-element positive electrode material has rounded morphology, a uniform particle size, less agglomeration, less adhesion, a high compaction density and a good structural stability, and when same is applied to a lithium ion battery, the energy density, rate capability, cyclic stability and safety of the lithium ion battery can be improved.

Provided are a composite silicon carbide substrate and a preparation method therefor. The composite silicon carbide substrate comprises a single crystal layer, a bonding layer and a support layer which are stacked in sequence; a surface of the single crystal layer is provided with a periodic atomic step structure; the atomic step structure comprises any one of a four-width step structure, a two-width step structure or a single-width step structure. The preparation method comprises: (1) bonding a support layer with an ion-implanted single crystal substrate, and performing a heat treatment and detaching to obtain an intermediate product of the composite silicon carbide substrate; and (2) subjecting a surface of a single crystal layer of the intermediate product of the composite silicon carbide substrate obtained in step (1) to oxidation modification and polish removal alternately, that is, forming a periodic atomic step structure on the surface of the single crystal layer, to obtain the composite silicon carbide substrate. The composite silicon carbide substrate meets the needs of high-voltage power devices for silicon carbide epitaxial layers with a large thickness and high quality, and the preparation method is simple and efficient, and has good controllability.

A condensing boiler (1) for a hybrid plant is described comprising two heat sources, namely said boiler (1) and a heat pump, wherein the boiler (1) is provided with a burner suitable for generating hot flue gas, a bundle of exchanging plates (7), an inlet (41) and an outlet (42) of technical liquid for a room heating apparatus of the hybrid plant. The boiler (1) has a head (2), a bottom (3), and a shell (4) adapted to define an internal volume for the storage of technical liquid. A separation frame (6) is provided in the internal volume of the boiler (1), adapted to divide said internal volume into a first chamber (51) and a second chamber (52).

Provided is a method for modifying a cell, which comprises the following steps: transfecting a target molecule and a screening marker molecule to a cell in a non-viral manner, so that the cell expresses the target molecule and the screening marker molecule. Also provided is a modified cell obtained using the method. The method can effectively enrich the desired cell and increase cell positivity with respect to the target molecule.

There is provided a fluorine-containing copolymer comprising tetrafluoroethylene unit, hexafluoropropylene unit, and perfluoro(propyl vinyl ether) unit, wherein the content of hexafluoropropylene unit is 7.6 to 10.3% by mass with respect to the whole of the monomer units; the content of perfluoro(propyl vinyl ether) unit is 1.3 to 2.4% by mass with respect to the whole of the monomer units; and the melt flow rate at 372°C is 4.5 to 9.5 g / 10 min.

There is provided a fluorine-containing copolymer comprising tetrafluoroethylene unit, hexafluoropropylene unit, and perfluoro(propyl vinyl ether) unit, wherein the copolymer has a content of hexafluoropropylene unit of 7.0 to 9.4% by mass with respect to the whole of the monomer units, a content of perfluoro(propyl vinyl ether) unit of 1.5 to 2.9% by mass with respect to the whole of the monomer units, and a melt flow rate at 372°C of 15 to 40 g / 10 min.

This disclosure relates to a polishing composition that includes at least one abrasive; at least one nitride removal rate reducing agent, an acid or a base; and water. The at least one nitride removal rate reduce agent can include a hydrophobic portion containing a C4 to C40 hydrocarbon group; and a hydrophilic portion containing at least one group selected from the group consisting of a sulfinite group, a sulfate group, a sulfonate group, a carboxylate group, a phosphate group, and a phosphonate group; in which the hydrophobic portion and the hydrophilic portion are separated by zero to ten alkylene oxide groups. The polishing composition can have a pH of from about 2 to about 6.5.

This application provides a secondary battery, a battery module, a battery pack, and an electric apparatus. The secondary battery includes a positive electrode plate and a non-aqueous electrolyte. The positive electrode plate includes a positive electrode active material. The positive electrode active material has a chemical formula of LiaAxMn1-yByP1-zCzO4-nDn, where A includes at least one of Zn, Al, Na, K, Mg, Nb, Mo, and W, B includes at least one of Ti, V, Zr, Fe, Ni, Mg, Co, Ga, Sn, Sb, Nb, and Ge, C includes at least one ofB (boron), S, Si, and N, and D includes at least one of S, F, Cl, and Br. The non-aqueous electrolyte includes an organic solvent. The organic solvent includes a first solvent. The first solvent includes one or more of compounds represented by formula 1. Rate performance and cycling performance of the secondary battery are improved.

A microorganism is cultivated in the presence of a carbon source. The microorganism is a transformed microorganism having an introduced fadH gene encoding 2,4-dienoyl-CoA reductase. That is, the transformed microorganism has an introduced foreign gene encoding a protein having an amino acid sequence of SEQ ID NO: 1 or an introduced foreign gene encoding a protein having an amino acid sequence that is at least 85% identical to the amino acid sequence of SEQ ID NO: 1. The carbon source contains an oil containing unsaturated fatty acids as constituents or free unsaturated fatty acids.

Disclosed in the present invention are a novel green lithium iron phosphate precursor, a preparation method therefor and an application thereof. The preparation method for the lithium iron phosphate precursor comprises the following steps: S 1, reacting a mixture of an iron source and a phosphoric acid solution, and grinding after the reaction is completed to obtain a product A; reacting a mixture of an organic acid solution, a lithium source, and a carbon source, and obtaining a product B after the reaction is completed, the preparation order of the product A and the product B being not limited; and S2, grinding the mixture of the product A and the product B to obtain a lithium iron phosphate precursor. In the preparation process of the lithium iron phosphate precursor of the present invention, the solid content can be greatly improved, the energy consumption of the subsequent process is low, the preparation method is simple, and the cost is low. The prepared lithium iron phosphate precursor has extremely small particle size and high charge and discharge rate.

Provided is a composition capable of forming an easy-drying coating on an application surface in a paint, an ink, and an adhesive which mainly contain polymers, or a coating liquid for a positive electrode, a negative electrode, a separator, and the like of a lithium-ion secondary battery. The coating composition containing a filler, a binder, a thickener, and a solvent, wherein the binder is at least one selected from a diene rubber and a (meth)acrylate polymer; a viscosity of the coating composition is 1.0 × 106 Pa·s or less as measured at a shear rate of 0.01 / s; and the following thixotropy index (TI) is 1.1 × 106 or more: thixotropyindexTI=viscosityofthecoatingcompositionasmeasuredatashearrateof0.01 / s / viscosityofthecoatingcompositionasmeasuredatashearrateof10000 / s.

Disclosed is a polishing pad including a polishing layer having a circular polishing surface, wherein the polishing pad is provided with a spiral groove or concentric grooves including a plurality of annular grooves arranged concentrically, the spiral groove and the concentric grooves being disposed spanning from a central region to a peripheral edge region of the polishing surface, and radial grooves including line segment-shaped grooves extending from the central region toward the peripheral edge region. The line segment-shaped grooves have a first end portion in a radial groove at a distance of 5 to 10% of the radius of the polishing surface from a center of the radial grooves, and a second end portion in a region at a distance of 35 to 70% of the radius of the polishing surface from the center of the radial grooves, and the line segment-shaped grooves have an average length of 30 to 65% of the radius of the polishing surface. A cross-sectional area Sa (mm2) of the line segment-shaped grooves and a cross-sectional area Sb (mm2) of the spiral groove or the concentric grooves satisfy 0.1 ≤ Sb / Sa < 1.0.

An apparatus for extracorporeal blood treatment comprises an extracorporeal blood circuit configured for connection either to a vascular access of a patient (P) or to a blood circuit of a high blood flow rate machine (36). A control unit (100) is configured for checking the connection of the extracorporeal blood circuit by performing the following procedure: receiving a measured pressure from a pressure sensor (25, 26); detecting if the extracorporeal blood circuit is connected to the vascular access of the patient (P) or to the blood circuit of the high blood flow rate machine (36) by performing an analysis of the measured pressure or of a parameter correlated to the measured pressure; issuing a signal if the connection to the vascular access of the patient (P) and / or the connection to the blood circuit of the high blood flow rate machine (36) is detected.

The present application provides a secondary battery, a battery module, a battery pack, and an electric device. The secondary battery includes: a positive electrode sheet and a non-aqueous electrolyte, where the positive electrode sheet includes a cathode active material with a core-shell structure, and the cathode active material includes a core and a shell covering the core; the core has a chemical formula of Li1+xMn1-yAyP1-zRzO4; where the first coating layer includes a crystalline pyrophosphate LiaMP2O7 and / or a crystalline pyrophosphate Mb(P2O7)c, the second coating layer includes a crystalline phosphate XPO4, and the third coating layer is carbon; and the non-aqueous electrolyte includes a first lithium salt and a first additive, where the first lithium salt includes one or more selected from the group consisting of LiN(CmF2m+1SO2)(CnF2n+1SO2) and Li(FSO2)2N, where m and n each are a positive integer; and the first additive includes one or more selected from the group consisting of compounds shown in Formula 1. The present application improves the cycling performance of a lithium manganese phosphate (LMP) secondary battery.         O=C=N-R1-N=C=O     Formula 1

Embodiments of this application provide a positive electrode active material and a preparation method thereof, a positive electrode plate, a secondary battery, a battery module, a battery pack, and an electric apparatus. The positive electrode active material includes a core and a shell layer enveloping the core, the core having a chemical formula LiaAxMn1-yByP1-zCzO4-nDn, where A includes one or more elements selected from Zn, Al, Na, K, Mg, Nb, Mo, and W, B includes one or more elements selected from Ti, V, Zr, Fe, Ni, Mg, Co, Ga, Sn, Sb, Nb, and Ge, C includes one or more elements selected from B, S, Si, and N, and D includes one or more elements selected from S, F, Cl, and Br; and the shell layer is a doped carbon layer, a doping element in the doped carbon layer including any one or more selected from nitrogen, phosphorus, sulfur, boron, and fluorine. The rate performance and cycling performance of a lithium manganese phosphate positive electrode active material are improved.

The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,

A thermoplastic polyurethane for polishing layer, in which a D hardness after saturated and swollen by water of 50 °C in a sheet with a thickness of 2 mm is less than 50, and a contact angle with water in a sheet with a thickness of 200 µm is 70 ° or less.

A reagent transfer device (10) and an immunological diagnostic apparatus. The reagent transfer device (10) comprises a transfer supporting mechanism (100) and reagent transfer mechanisms (200), wherein a plurality of reagent transfer mechanisms (200) are provided, and the plurality of reagent transfer mechanisms (200) are respectively mounted to the transfer supporting mechanism (100); and each reagent transfer mechanism (200) comprises a transfer base (210), a reagent needle (220) and a multidirectional movement component (230), the transfer base (210) being mounted to the transfer support mechanism (100), the multidirectional movement component (230) being arranged on the transfer base (210), and the multidirectional movement component (230) being connected to the reagent needle (220) so as to drive the reagent needle (220) to move. The immunological diagnostic apparatus comprises the reagent transfer device (10). The reagent transfer device (10) can solve the problems of the low reagent transfer efficiency and low detection efficiency of a chemiluminescence immunoassay system in the prior art.

The present application provides a secondary battery, a battery module, a battery pack and an electrical apparatus. The secondary battery includes a positive electrode plate and a non-aqueous electrolyte solution. A positive electrode active material includes an inner core and a shell cladding the inner core. The inner core includes Li1+xMn1-yAyP1-zRzO4. The shell includes a first cladding layer cladding the inner core and a second cladding layer cladding the first cladding layer. The first cladding layer includes pyrophosphate MP2O7 and phosphate XPO4. The second cladding layer includes carbon. The non-aqueous electrolyte solution includes a first additive. The first additive includes one or more compounds in a group consisting of a compound shown in Formula 1, a compound shown in Formula 2 and a compound shown in Formula 3. The rate performance, cycling performance and high temperature stability of a lithium manganese phosphate secondary battery are increased.

Provided is a coating composition that can be applied with excellent high-speed coating properties and surface smoothness in a paint, an ink, and an adhesive which mainly contain polymers, or a coating liquid for a positive electrode, a negative electrode, a separator, and the like of a lithium-ion secondary battery. The coating composition containing a filler, a binder, a thickener, and a solvent, wherein an aspect ratio of the filler is 2 or more; the binder is at least one selected from a diene rubber and a (meth)acrylate polymer; a viscosity of the coating composition is 1.0 × 106 Pa·s or less as measured at a shear rate of 0.01 / s; and the following thixotropy index (TI) is 1.1 × 106 or more: [thixotropy index (TI)] = [viscosity of the coating composition as measured at a shear rate of 0.01 / s] / [viscosity of the coating composition as measured at a shear rate of 10000 / s].

Disclosed herein are a cobalt-free positive electrode material slurry, a preparation method therefor and an application thereof. The cobalt-free positive electrode material slurry comprises a cobalt-free positive electrode material, a solvent, a sulfone compound containing unsaturated bonds and an auxiliary agent. When the total parts by weight of the cobalt-free positive electrode material and the auxiliary agent are 100 parts, the parts by weight of the solvent are 25-40 parts, and the parts by weight of the sulfone compound containing the unsaturated bond are 1-7 parts. A positive electrode pole piece formed by the cobalt-free positive electrode material slurry may better isolate air and moisture and protect the cobalt-free positive electrode material of a core component. The lithium ion battery formed thereby has a relatively high first discharge capacity, capacity retention rate and first Coulombic efficiency, and is relatively safe.

The present invention provides a single-crystal high-nickel positive electrode material and a preparation method therefor and an application thereof. The preparation method comprises the following steps: (1) mixing a precursor, a lithium source, and a nano oxide, and performing primary sintering treatment in an oxygen-containing atmosphere to obtain a primary sintered material; and (2) mixing the primary sintered material obtained in step (1) with a titanium source and a cobalt source, and performing secondary sintering treatment in an oxygen-containing atmosphere to obtain the single-crystal high-nickel positive electrode material. The present invention uses a Ti / Co co-coating method, the residual alkali amount of the prepared single-crystal high-nickel positive electrode material can be greatly reduced, and the capacity and the rate capability can also be kept at a high level, so that the technological process is reduced, and the cost is reduced.

An apparatus for extracorporeal blood treatment comprises an extracorporeal blood circuit configured for connection either to a vascular access of a patient (P) or to a blood circuit of a high blood flow rate machine (36). A control unit (100) is configured for checking the connection of the extracorporeal blood circuit by performing the following procedure: receiving a measured pressure from a pressure sensor (25, 26); detecting if the extracorporeal blood circuit is connected to the vascular access of the patient (P) or to the blood circuit of the high blood flow rate machine (36) by performing an analysis of the measured pressure or of a parameter correlated to the measured pressure; issuing a signal if the connection to the vascular access of the patient (P) and / or the connection to the blood circuit of the high blood flow rate machine (36) is detected.