19results about How to "High rate" patented technology

Provided in the present invention are a class of compounds as represented by formula (I), or a prodrug, a tautomer, a stereoisomer, a solvate, and an isotopic derivative thereof, or a pharmaceutically acceptable salt thereof. The compound has an SHP2 kinase inhibitory effect and can be used for treating and / or preventing diseases, disorders, and conditions mediated by SHP2 activity, such as tumors, cancers, cancer metastasis, cardiovascular diseases, immune disorders, visual disorders, etc.

The present invention comprises: a first tray for forming a portion of an ice-making cell; a second tray forming the other portion of the ice-making cell, and capable of moving relative to the first tray; an ice bin for storing ice separated from the first and second trays; and a full-ice sensing lever for moving together with the second tray in a predetermined range.

The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,

A single-crystal-type multi-element positive electrode material, and a preparation method therefor and an application thereof. The positive electrode material satisfies the following conditions: single crystal sizes DPS90, DPS10 and DPS50 of the positive electrode material, which are measured by means of SEM, satisfying the following relationship: 0.1≤B90=(DPS90-DPS10) / DPS50≤1.5; and the agglomeration rate of the positive electrode material being less than or equal to 20%, wherein DPS90 represents that 90% of the single crystal size of the positive electrode material is less than DPS90, DPS50 represents that 50% of the single crystal size of the positive electrode material is less than DPS50, and DPS10 represents that 10% of the single crystal size of the positive electrode material is less than DPS10. The single-crystal-type multi-element positive electrode material has rounded morphology, a uniform particle size, less agglomeration, less adhesion, a high compaction density and a good structural stability, and when same is applied to a lithium ion battery, the energy density, rate capability, cyclic stability and safety of the lithium ion battery can be improved.

Provided are a composite silicon carbide substrate and a preparation method therefor. The composite silicon carbide substrate comprises a single crystal layer, a bonding layer and a support layer which are stacked in sequence; a surface of the single crystal layer is provided with a periodic atomic step structure; the atomic step structure comprises any one of a four-width step structure, a two-width step structure or a single-width step structure. The preparation method comprises: (1) bonding a support layer with an ion-implanted single crystal substrate, and performing a heat treatment and detaching to obtain an intermediate product of the composite silicon carbide substrate; and (2) subjecting a surface of a single crystal layer of the intermediate product of the composite silicon carbide substrate obtained in step (1) to oxidation modification and polish removal alternately, that is, forming a periodic atomic step structure on the surface of the single crystal layer, to obtain the composite silicon carbide substrate. The composite silicon carbide substrate meets the needs of high-voltage power devices for silicon carbide epitaxial layers with a large thickness and high quality, and the preparation method is simple and efficient, and has good controllability.

A condensing boiler (1) for a hybrid plant is described comprising two heat sources, namely said boiler (1) and a heat pump, wherein the boiler (1) is provided with a burner suitable for generating hot flue gas, a bundle of exchanging plates (7), an inlet (41) and an outlet (42) of technical liquid for a room heating apparatus of the hybrid plant. The boiler (1) has a head (2), a bottom (3), and a shell (4) adapted to define an internal volume for the storage of technical liquid. A separation frame (6) is provided in the internal volume of the boiler (1), adapted to divide said internal volume into a first chamber (51) and a second chamber (52).

Provided is a method for modifying a cell, which comprises the following steps: transfecting a target molecule and a screening marker molecule to a cell in a non-viral manner, so that the cell expresses the target molecule and the screening marker molecule. Also provided is a modified cell obtained using the method. The method can effectively enrich the desired cell and increase cell positivity with respect to the target molecule.

This disclosure relates to a polishing composition that includes at least one abrasive; at least one nitride removal rate reducing agent, an acid or a base; and water. The at least one nitride removal rate reduce agent can include a hydrophobic portion containing a C4 to C40 hydrocarbon group; and a hydrophilic portion containing at least one group selected from the group consisting of a sulfinite group, a sulfate group, a sulfonate group, a carboxylate group, a phosphate group, and a phosphonate group; in which the hydrophobic portion and the hydrophilic portion are separated by zero to ten alkylene oxide groups. The polishing composition can have a pH of from about 2 to about 6.5.

A microorganism is cultivated in the presence of a carbon source. The microorganism is a transformed microorganism having an introduced fadH gene encoding 2,4-dienoyl-CoA reductase. That is, the transformed microorganism has an introduced foreign gene encoding a protein having an amino acid sequence of SEQ ID NO: 1 or an introduced foreign gene encoding a protein having an amino acid sequence that is at least 85% identical to the amino acid sequence of SEQ ID NO: 1. The carbon source contains an oil containing unsaturated fatty acids as constituents or free unsaturated fatty acids.

Provided is a composition capable of forming an easy-drying coating on an application surface in a paint, an ink, and an adhesive which mainly contain polymers, or a coating liquid for a positive electrode, a negative electrode, a separator, and the like of a lithium-ion secondary battery. The coating composition containing a filler, a binder, a thickener, and a solvent, wherein the binder is at least one selected from a diene rubber and a (meth)acrylate polymer; a viscosity of the coating composition is 1.0 × 106 Pa·s or less as measured at a shear rate of 0.01 / s; and the following thixotropy index (TI) is 1.1 × 106 or more: thixotropyindexTI=viscosityofthecoatingcompositionasmeasuredatashearrateof0.01 / s / viscosityofthecoatingcompositionasmeasuredatashearrateof10000 / s.

Disclosed is a polishing pad including a polishing layer having a circular polishing surface, wherein the polishing pad is provided with a spiral groove or concentric grooves including a plurality of annular grooves arranged concentrically, the spiral groove and the concentric grooves being disposed spanning from a central region to a peripheral edge region of the polishing surface, and radial grooves including line segment-shaped grooves extending from the central region toward the peripheral edge region. The line segment-shaped grooves have a first end portion in a radial groove at a distance of 5 to 10% of the radius of the polishing surface from a center of the radial grooves, and a second end portion in a region at a distance of 35 to 70% of the radius of the polishing surface from the center of the radial grooves, and the line segment-shaped grooves have an average length of 30 to 65% of the radius of the polishing surface. A cross-sectional area Sa (mm2) of the line segment-shaped grooves and a cross-sectional area Sb (mm2) of the spiral groove or the concentric grooves satisfy 0.1 ≤ Sb / Sa < 1.0.

An apparatus for extracorporeal blood treatment comprises an extracorporeal blood circuit configured for connection either to a vascular access of a patient (P) or to a blood circuit of a high blood flow rate machine (36). A control unit (100) is configured for checking the connection of the extracorporeal blood circuit by performing the following procedure: receiving a measured pressure from a pressure sensor (25, 26); detecting if the extracorporeal blood circuit is connected to the vascular access of the patient (P) or to the blood circuit of the high blood flow rate machine (36) by performing an analysis of the measured pressure or of a parameter correlated to the measured pressure; issuing a signal if the connection to the vascular access of the patient (P) and / or the connection to the blood circuit of the high blood flow rate machine (36) is detected.

Embodiments of this application provide a positive electrode active material and a preparation method thereof, a positive electrode plate, a secondary battery, a battery module, a battery pack, and an electric apparatus. The positive electrode active material includes a core and a shell layer enveloping the core, the core having a chemical formula LiaAxMn1-yByP1-zCzO4-nDn, where A includes one or more elements selected from Zn, Al, Na, K, Mg, Nb, Mo, and W, B includes one or more elements selected from Ti, V, Zr, Fe, Ni, Mg, Co, Ga, Sn, Sb, Nb, and Ge, C includes one or more elements selected from B, S, Si, and N, and D includes one or more elements selected from S, F, Cl, and Br; and the shell layer is a doped carbon layer, a doping element in the doped carbon layer including any one or more selected from nitrogen, phosphorus, sulfur, boron, and fluorine. The rate performance and cycling performance of a lithium manganese phosphate positive electrode active material are improved.

The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,

A thermoplastic polyurethane for polishing layer, in which a D hardness after saturated and swollen by water of 50 °C in a sheet with a thickness of 2 mm is less than 50, and a contact angle with water in a sheet with a thickness of 200 µm is 70 ° or less.

Provided is a coating composition that can be applied with excellent high-speed coating properties and surface smoothness in a paint, an ink, and an adhesive which mainly contain polymers, or a coating liquid for a positive electrode, a negative electrode, a separator, and the like of a lithium-ion secondary battery. The coating composition containing a filler, a binder, a thickener, and a solvent, wherein an aspect ratio of the filler is 2 or more; the binder is at least one selected from a diene rubber and a (meth)acrylate polymer; a viscosity of the coating composition is 1.0 × 106 Pa·s or less as measured at a shear rate of 0.01 / s; and the following thixotropy index (TI) is 1.1 × 106 or more: [thixotropy index (TI)] = [viscosity of the coating composition as measured at a shear rate of 0.01 / s] / [viscosity of the coating composition as measured at a shear rate of 10000 / s].

Disclosed herein are a cobalt-free positive electrode material slurry, a preparation method therefor and an application thereof. The cobalt-free positive electrode material slurry comprises a cobalt-free positive electrode material, a solvent, a sulfone compound containing unsaturated bonds and an auxiliary agent. When the total parts by weight of the cobalt-free positive electrode material and the auxiliary agent are 100 parts, the parts by weight of the solvent are 25-40 parts, and the parts by weight of the sulfone compound containing the unsaturated bond are 1-7 parts. A positive electrode pole piece formed by the cobalt-free positive electrode material slurry may better isolate air and moisture and protect the cobalt-free positive electrode material of a core component. The lithium ion battery formed thereby has a relatively high first discharge capacity, capacity retention rate and first Coulombic efficiency, and is relatively safe.

An apparatus for extracorporeal blood treatment comprises an extracorporeal blood circuit configured for connection either to a vascular access of a patient (P) or to a blood circuit of a high blood flow rate machine (36). A control unit (100) is configured for checking the connection of the extracorporeal blood circuit by performing the following procedure: receiving a measured pressure from a pressure sensor (25, 26); detecting if the extracorporeal blood circuit is connected to the vascular access of the patient (P) or to the blood circuit of the high blood flow rate machine (36) by performing an analysis of the measured pressure or of a parameter correlated to the measured pressure; issuing a signal if the connection to the vascular access of the patient (P) and / or the connection to the blood circuit of the high blood flow rate machine (36) is detected.