12 results about "Systemic blood" patented technology

The invention relates to the technical field of medical adsorbents for blood perfusion, and discloses an application of a trans-cyclooctene group adsorbent based on a biological orthogonal reaction in preparation of a circulating tumor cell clearing preparation. The adsorbent adopts sephadex microspheres as a carrier, the surface of the carrier is modified with a trans-cyclooctene (TCO) group, a tetrazine (Tz) group is taken in by CTCs through modified mannose, the Tz group is expressed on the surface of a CTCs cell membrane in the form of glycoprotein through a Roseman-Warden pathway in cells, TCO and Tz are subjected to a biological orthogonal reaction specifically, and the adsorption capacity of the adsorbent is improved. The sephadex microsphere adsorbent can effectively enrich and remove CTCs in blood of the whole body of a patient through adsorption, and compared with a conventional single-antibody or multi-antibody capture technology, the sephadex microsphere adsorbent does not depend on antibody-antigen binding, and the capture efficiency of the CTCs can be remarkably improved through a biological orthogonal reaction.

The invention belongs to the field of biological medicine, and particularly relates to lipid nanoparticles for local drug delivery, a preparation method of the lipid nanoparticles and application of the lipid nanoparticles to preparation of anti-scar drugs. The lipid nanoparticle comprises a lipid carrier and nucleic acid wrapped by the lipid carrier, and the lipid carrier comprises the following components: an ionizable lipid, a permanent cationic lipid, a pegylated lipid, an auxiliary phospholipid and a sterol compound; the molar ratio of the ionizable lipid to the permanent cationic lipid to the pegylated lipid to the auxiliary phospholipid to the sterol compound is (25-45): (5-25): (1-2): (5-15): (35-40). In order to solve the problem of single administration of lipid nanoparticles in the prior art, the lipid nanoparticles are designed to be externally applied and applied for local administration through proportion regulation and control, so that the targeting property is improved, and the administration concentration is increased. Whole-body blood circulation is avoided, and toxic and side effects and off-target performance are reduced. Therefore, the dual purposes of synergism and toxicity reduction are achieved.

The present disclosure provides a method for delivering a neuroprotective polypeptide to at least a portion of a central nervous system (CNS) of a subject. The method includes administering to the systemic blood circulation of the subject a therapeutically effective amount of a neuroprotective polypeptide by a controlled-release formulation or a device providing a sustained release of the neuroprotective polypeptide including at least one neuroprotective polypeptide selected from the group consisting of GLP-1, exendin-4, or a therapeutically effective GLP-1 or exendin-4 analogue; the neuroprotective polypeptide binds to and activates a receptor that binds at least one of GLP-1, exendin-4, or a combination thereof; and the controlled-release neuroprotective formulation or the sustained release of the neuroprotective polypeptide enhances the delivery of the neuroprotective polypeptide across a blood-brain barrier (BBB) of the subject to at least a portion of the CNS relative to a rapid release formulation of the neuroprotective polypeptide. Also disclosed is a method of treating a subject with a CNS-related disease or reducing at least one symptom of a CNS-related disease in a subject in need thereof.

The invention discloses a treading type leg scraping device which comprises a vertical rod type auxiliary walking device and a leg scraping piece, a first binding piece is connected to the leg scraping piece, a leg scraping protruding block is arranged on the inner side of the leg scraping piece, the vertical rod type auxiliary walking device comprises a pedal and a second binding piece, and a supporting device is connected to the pedal. A rotating frame is rotationally connected to the upper portion of the supporting device, a connecting structure is arranged between the rotating frame and the leg scraping piece, and when a patient conducts normal walking gait training through the pedal and the second binding piece, the device can synchronously drive the leg scraping protruding block to scrape the thigh. The mechanical stimulation of the leg scraping bumps on the thigh skin and subcutaneous tissues can induce the human body to generate benign stress response and repair response, so that the walking ability is recovered, local and whole body blood circulation is effectively promoted, metabolic waste discharge is accelerated, and muscular pain and stiffness caused by long-term braking or sport injury are relieved.

The utility model relates to the technical field of household portable massage equipment, in particular to a foot massager which comprises a bottom shell, a massage machine core, an upper shell and an upper air bag, and the massage machine core comprises an upper cover, a lower cover, at least four massage heads, a jacking head, a driving mechanism and an inflation and deflation assembly. And the inflating and deflating assembly and the driving mechanism are arranged in a space formed by folding the upper cover and the lower cover. The upper air bag completely wraps the instep part and massages the instep part by intermittently extruding the instep part, the massage head continuously rotates under the action of the driving mechanism and is used for kneading and massaging the sole part, kneading stimulation can promote local blood circulation, blood can flow more smoothly in the sole area, and the massage effect is better. The health-care insole can effectively massage the foot, strengthen the blood pumping function of the heart and further promote blood circulation of the whole body, so that the workload of the heart can be remarkably relieved, various uncomfortable symptoms such as pain and numbness caused by unsmooth blood flow of the foot sole can be effectively relieved, and the massage effect is obvious.

This invention provides a topical finasteride formulation and its preparation method, belonging to the field of pharmaceutical formulation technology. The topical finasteride formulation provided by this invention is a topical dosage form, comprising finasteride and excipients; after scalp administration, the concentration in hair follicles and the epidermis is 999-5021 pg / mL, and the systemic blood concentration is 17.1-178.9 pg / mL; the systemic blood concentration is 1-10% of that of oral finasteride formulations. The method involves preparing finasteride and excipients, followed by steps of dissolving / preparing the matrix, fine filtration / homogenization, and filling to obtain finasteride topical formulations of different dosage forms. This invention effectively solves the shortcomings of existing finasteride formulations, such as high systemic absorption, high risk of adverse reactions, and difficulty in industrializing the process, making it suitable for large-scale clinical application in androgenetic alopecia, combining efficacy and safety.

A process for analysing chromosome interactions relating to colorectal cancer. The invention allows determination of the colorectal cancer status using a systemic blood-based profile of a chromosome conformation signature (3D genomic) state. This avoids the need to use invasive procedures. In particular, the invention allows blood-based detection of colorectal cancer status and distinguishing between groups of individuals who differ in their colorectal cancer status. This also results in a test of high sensitivity and specificity.

The invention relates to the field of insoles, in particular to an insole capable of improving sleep. According to the invention, a six-layer composite structure design is adopted, and all layers are sequentially compounded and fixed from top to bottom; the insole sequentially comprises a first nanometer bamboo carbon fiber cloth layer, a second acupoint massage convex covering layer, a third arch protection cushion layer, a fourth hard natural plant fiber supporting layer, a fifth plastic anti-skid layer and a sixth round vibration cushion layer from top to bottom. All the layers are adhered and fixed through environment-friendly hot melt adhesive. The functions of all the layers of the insole are matched with one another, foot fatigue is comprehensively relieved, blood circulation of the whole body is improved, physical and mental relaxation is promoted, and therefore the purpose of assisting in improving sleep is achieved.

The invention belongs to the field of basic medicine, and particularly relates to a method for establishing a blood coagulation disorder animal model, which comprises the following steps of: performing intragastric administration on a healthy rat with a preparation containing podophyllotoxin according to the dose of 10mg / kg per day, and continuously performing administration for 4 days; wherein the drug administration can induce the rat to generate blood coagulation disorder phenotypes, and the phenotypes at least comprise prothrombin time prolonging, activated partial thromboplastin time prolonging and thrombin time prolonging. According to the establishment method of the blood coagulation disorder animal model, it is determined that podophyllotoxin can cause whole-body blood coagulation disorder, and the stable and repeatable blood coagulation disorder animal model is provided.

The application relates to a post-illness limb function recovery training device, which comprises a chassis, a cushion fixed at the upper end of the chassis and a fixing frame fixed at one end of the chassis, two sliding frames are fixed at the upper end of the fixing frame, and the right lower end of the sliding frame is fixedly connected with the chassis. The device can move forward and backward through the soft foot cover and the horizontal rod after operation, and can perform lower limb training such as leg stretching and knee bending, improve the knee joint activity, prevent postoperative joint stiffness, and can separate and approach the two soft foot covers, open the two feet from the close to the two sides, and then recover the close, improve the hip joint activity and the lower limb stability, further improve the postoperative lower limb rehabilitation training effect, and in addition, during the lower limb training, the backrest can be slightly rotated, the upper body can be moderately moved during the lower limb training, the whole body coordination is enhanced, the whole body blood circulation is promoted, and the risk of local blood stasis of the upper body is reduced.

The utility model discloses a prone position ventilation pillow capable of preventing pressure sores, and relates to the technical field of medical equipment. The adjusting mechanism comprises a clamping and locking assembly, a supporting assembly and a soft cushion assembly, the clamping and locking assembly comprises a limiting groove formed in the fixing plate, the limiting groove is in sliding connection with a limiting block, the limiting block is fixedly connected with a spring, the spring is fixedly connected with a bearing block, and the bearing block is fixedly connected with the supporting assembly. The bearing block is fixedly connected with a clamping block. Through the adjusting mechanism, a person can turn over the turning plate by pressing the clamping blocks to drive the ventilation pillow to incline to a proper angle and clamp the two clamping blocks into the specific clamping holes to complete limiting by utilizing the elastic acting force of the spring, so that a patient can conveniently lie on the ventilation pillow in a prone position, and the legs, the head and the abdomen are mutually inclined; the two arms can also annularly hang down the two sides of the ventilation pillow and the turnover plate, normal blood circulation of the whole body of the patient is ensured, and the practicability of the device is improved.

The invention discloses a universal detection plate for blood type and antihuman globulin tests and application of the universal detection plate. The universal detection plate can be suitable for detection of all blood group antigens (including ABO blood group positive typing and reverse typing) and anti-human globulin, is good in detection effect and high in sensitivity, can well detect weak positive samples, and can present different degrees of agglutination strength. And the detection method based on the universal detection plate is simple and convenient to operate (4 * 96 tests per 10 minutes), clear in result, clear in negative and positive boundary and easy to interpret. The kit is simple in structure, convenient to operate, capable of avoiding tedious operation such as conventional anti-human globulin test washing and the like, capable of improving detection efficiency, more suitable for large-scale sample detection, free of missing detection of system blood group antibodies such as KEL and the like and capable of meeting the requirements for clinical rapid cross matching of blood and the like.