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2159 results about "Dosage form" patented technology

Dosage forms (also called unit doses) are pharmaceutical drug products in the form in which they are marketed for use, with a specific mixture of active ingredients and inactive components (excipients), in a particular configuration (such as a capsule shell, for example), and apportioned into a particular dose. For example, two products may both be amoxicillin, but one is in 500 mg capsules and another is in 250 mg chewable tablets. The term unit dose can also sometimes encompass non-reusable packaging as well (especially when each drug product is individually packaged), although the FDA distinguishes that by unit-dose "packaging" or "dispensing". Depending on the context, multi(ple) unit dose can refer to distinct drug products packaged together, or to a single drug product containing multiple drugs and/or doses. The term dosage form can also sometimes refer only to the pharmaceutical formulation of a drug product's constituent drug substance(s) and any blends involved, without considering matters beyond that (like how it is ultimately configured as a consumable product such as a capsule, patch, etc.). Because of the somewhat vague boundaries and unclear overlap of these terms and certain variants and qualifiers within the pharmaceutical industry, caution is often advisable when conversing with someone who may be unfamiliar with another person's use of the term.

Compounds and combinations thereof for treating neurological and psychiatric conditions

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Compounds and combinations thereof for treating neurological and psychiatric conditions

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Compounds and combinations thereof for treating neurological and psychiatric conditions

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, an antidepressant, such as bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Compounds and combinations thereof for treating neurological and psychiatric conditions

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Compounds and combinations thereof for treating neurological and psychiatric conditions

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, an antidepressant, such as bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Methods and bioavailable highly permeable compounds for the treatment of viral diseases

Provided are methods and compounds for treating (or for use in manufacturing a pharmaceutical dosage form to treat) viral infections by administering avermectin-based bioavailable highly permeable compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of SARS-CoV-2, dengue, chikungunya, yellow fever, Zika and other viral infections.
Owner:DIDENKO KIRILL

Dry powder formulations of epinephrine and associated methods

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.
Owner:BELHAVEN BIOPHARMA INC

Intelligent traditional Chinese medicine prescription processing and preparing system

The invention provides an intelligent traditional Chinese medicine prescription processing and preparation system which integrates a prescription acquisition module, a medicinal material selection module, a dosage form analysis module, a dosage form decision module, an intelligent preparation module, an intelligent distribution module and the like. The system can receive traditional Chinese medicine prescriptions made by doctors in real time, intelligently recommend grades and production places of medicinal materials, analyze and display advantages and disadvantages of various suitable dosage forms, and allow patients to autonomously select dosage forms. And the intelligent preparation module adopts automatic equipment and an intelligent control technology, so that the accuracy and high efficiency of the preparation process are ensured. And the intelligent distribution module is responsible for safely and timely delivering the medicine to the patient. In addition, the system further has the functions of medicinal material producing area selection, intelligent medicine decocting, intelligent medicine sorting and the like, and the personalized and intelligent levels of traditional Chinese medicine prescriptions are further improved. Through comprehensive application of advanced technologies, full-chain intelligent management of traditional Chinese medicine prescriptions from issuing to preparation and distribution is realized, the efficiency and accuracy of traditional Chinese medicine preparation are improved, and individual requirements of patients are met.
Owner:湖南暄程科技有限公司

Bupropion as a modulator of drug activity

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Pharmaceutical composition of paclitaxel dimer prodrug nanoparticles and traditional Chinese medicine compound and application of pharmaceutical composition

The invention relates to the technical field of biological medicine, and discloses a pharmaceutical composition of paclitaxel dimer prodrug nanoparticles and a traditional Chinese medicine compound and application of the pharmaceutical composition, and the pharmaceutical composition is composed of Qiyuansanlong prescription freeze-dried powder and paclitaxel dimer prodrug nanoparticles; wherein the paclitaxel dimer prodrug nanoparticles comprise one of NQO1 response type PTX dimer prodrug nanoparticles (PTX-Q-PTX NPs) or GSH (glutathione) response type PTX dimer prodrug nanoparticles (PTX-SeSe-PTXNPs), and the paclitaxel dimer prodrug nanoparticles comprise one of NQO1 response type PTX dimer prodrug nanoparticles (PTX-Q-PTX NPs) and GSH response type PTX dimer prodrug nanoparticles (PTX-SeSe-PTXNPs). According to the pharmaceutical composition disclosed by the invention, a traditional Chinese and western medicine synergistic treatment system is innovatively constructed, and the advantage of multi-dimensional synergistic interaction is shown. Firstly, an NQO1 / GSH double-response type intelligent release system is adopted, and a biomarker highly expressed by tumor tissue can be specifically responded to realize precise drug release, so that the PTX concentration in tumors is improved compared with that of a traditional dosage form, and meanwhile, the drug circulation time is prolonged. Secondly, the active ingredients in the Qiyuansanlong prescription freeze-dried powder can significantly down-regulate the PD-L1 expression level, synergistically enhance CD4 + T and CD8 + T cell infiltration, and form chemical-immune dual killing effects.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Bupropion as a modulator of drug activity

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Bupropion as a modulator of drug activity

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Traditional Chinese medicine composition with effects of benefiting qi, nourishing blood, invigorating spleen and tonifying kidney and preparation method of traditional Chinese medicine composition

The invention discloses a traditional Chinese medicine composition with the effects of benefiting qi, nourishing blood, invigorating the spleen and tonifying the kidney and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: cistanche, ginseng, American ginseng, astragalus membranaceus, medlar, rhizoma polygonati, oyster peptide, angelica sinensis, radix rehmanniae preparata, donkey-hide gelatin, fructus amomi, pericarpium citri reticulatae, hawthorn, folium cortex eucommiae, radix puerariae, liquorice and the like. The preparation method comprises the following steps: respectively crushing the medicinal materials, dissolving the colla corii asini, mixing, adding water, granulating and the like. The composition can be prepared into various dosage forms such as granules, capsules, tablets, oral liquid and the like. Experiments show that the traditional Chinese medicine composition can effectively improve the symptoms of deficiency of qi and blood (increasing erythrocyte count and hemoglobin content), weakness of spleen and stomach (increasing body weight and improving pepsin activity) and kidney deficiency (reducing creatinine and urea nitrogen content and improving SOD activity), and acute toxicity experiments show that the toxicity is slightly reversible under high dosage, and the safety is good under therapeutic dosage. The traditional Chinese medicine composition has potential application value in the aspect of preparing medicines for benefiting qi, nourishing blood, invigorating spleen and tonifying kidney.
Owner:SHANDONG RENYITANG BIOTECHNOLOGY CO LTD

Bupropion as a modulator of drug activity

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Owner:ANTECIP BIOVENTURES II LLC

Pharmaceutical composition for reversing pancreatic cancer gemcitabine drug resistance and application thereof

PendingCN120361231AOrganic active ingredientsDigestive systemGemcitabine resistancePancreas Cancers
The invention discloses a pharmaceutical composition for reversing pancreatic cancer gemcitabine drug resistance and application of the pharmaceutical composition, and belongs to the technical field of biological medicine. The composition comprises a generic FGFR inhibitor delatinib and gemcitabine, the concentration of the delatinib is 25 to 50 mg / kg, and the concentration of the gemcitabine is 20 to 30 mg / kg. By inhibiting an FGFR2 / FGFR3 signal channel and reducing the expression of FGFR protein in drug-resistant cells, the chemosensitivity of gemcitabine is synergistically enhanced, the apoptosis induction rate is increased by more than two times, and the synergic index (CI) is less than 1. In-vitro and nude mouse transplantation tumor experiments prove that the composition can significantly inhibit the proliferation of gemcitabine drug-resistant pancreatic cancer cells. The Gemcitabine drug-resistant pancreatic cancer drug can be used for preparing a drug for treating Gemcitabine drug-resistant pancreatic cancer with high FGFR3 expression, patients are screened through immunohistochemistry or gene sequencing, intravenous injection or oral administration is adopted, dosage forms comprise freeze-dried powder injection, capsules or tablets, and a new strategy is provided for pancreatic cancer drug-resistant treatment.
Owner:ZHEJIANG CANCER HOSPITAL

Dosage forms for Tyk2 inhibitors

Stable and bioavailable formulations and dosage forms comprising a dispersion (e.g., spray-dried dispersion) of solid amorphous 6-(cyclopropancamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide (Formula (I): BMS-986165) in a solid polymer matrix are provided for the treatment of auto-immune and auto-inflammatory diseases such as an inflammatory bowel disease (IBD) and psoriasis.
Owner:BRISTOL MYERS SQUIBB CO

Modified-release oral pharmaceutical dosage form and preparation method therefor

Disclosed are a modified-release oral pharmaceutical dosage form and a related preparation method therefor, for example, a three-dimensional printing method is used.
Owner:TRIASTEK INC

Bactericidal composition containing fluxapyroxad and thiediazole copper

InactiveCN107771825ASynergistic effect is obviousDelay key drug resistanceBiocideFungicidesBacterial compositionPhytophthora sp.
The invention relates to a bactericidal composition containing fluxapyroxad and thiediazole copper. The bacterial composition is compounded from fluxapyroxad and thiediazole copper in a binary mode, wherein a mass ratio of fluxapyroxad to thiediazole copper is (1-50) to (50-1); a mass fraction of fluxapyroxad and thiediazole in the preparation is 1%-80%, and the rest of the preparation is auxiliary components which are allowed to use and are acceptable in a pesticide. A dosage form of the bactericidal composition is missible oil, a suspending agent, wettable powder, a water dispersible granule, emulsion in water, microemulsion, a granule and a micro-capsule. The bactericidal composition is mainly used for controlling plant gray mold, peronospora and phytophthora germs.
Owner:HAILIR PESTICIDES & CHEM GRP

Antibody drug conjugates comprising trabectedin and rubitedin derivatives

The invention relates to novel trabectedin and rubitedin derivatives, corresponding antibody drug conjugates and a method for preparing the antibody drug conjugates. The present invention also relates to a pharmaceutical dosage form comprising a novel trabectedin or rubitedin derivative or a corresponding antibody drug conjugate. Furthermore, the present invention relates to novel trabectedin and rubitedin derivatives, corresponding antibody drug conjugates and corresponding pharmaceutical dosage forms for use as a medicament or for the treatment of specific cancer types.
Owner:ABBVIE GROUP HOLDINGS LTD

Use of cannabinoids in the treatment of epilepsy

The present invention relates to the use of cannabidiol (CBD) in the treatment of epilepsy which results from mutation of the KCNT1 gene. The CBD used is in the form of a highly purified extract of Cannabis such that the CBD is present at greater than 98% of the total extract (w / w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) is present in an amount of from 0.02 to 0.1% (w / w). In an alternative embodiment the CBD may be in a synthetic form. In use the CBD may also be used concomitantly with one or more other anti-epileptic drugs (AED). The CBD may be formulated for administration separately, sequentially or simultaneously with one or more AED or the combination may be provided in a single dosage form. Where the CBD is formulated for administration separately, sequentially or simultaneously it may be provided as a kit or together with instructions to administer the one or more components in the manner indicated. It may also be used as the sole medication, i.e. as a monotherapy.
Owner:JAZZ PHARM RES UK LTD

Dosage unit form(s) comprising BTS and BTS(OMe) for use in boron neutron capture therapy and methods thereof

Borylated Amino Acid compositions comprising tyrosine derivatives BTS and BTS(OMe) and novel methods of making BTS and BTS(OMe) are disclosed herein. Consequently, the BTS and / or BTS(OMe) can be scaled up to commercial scale and administered to patients as a Neutron Capture Agent and provide a method of treating cancer, immunological disorders, and other disease by utilizing a Neutron Capture Therapy modality.
Owner:TAE LIFE SCIENCES LLC

Ginseng oral soluble film and preparation method thereof

The invention discloses a ginseng oral soluble film and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. The ginseng oral soluble film prepared by the invention comprises a ginseng extract, a ginseng extractum, a filling agent, an adhesive, a plasticizing forming agent and a seasoning component, is a novel dosage form, is convenient to take and carry, and provides a novel ginseng product and a consumption mode; meanwhile, when the oral liquid is placed on the tongue, the oral liquid can be rapidly dissolved and release drugs in saliva without drinking water, the compliance of a user can be greatly improved, and the preparation process has low requirements on preparation instruments, is low in cost, is beneficial to large-scale industrial production, does not generate or generates little three wastes, meets the requirements of sustainable development, and has a good application prospect.
Owner:SUZHOU WAYNES BIOTECHNOLOGY CO LTD

Capsicum growth regulator based on compounding of propionyl brassinolide and amino-oligosaccharin and application of capsicum growth regulator

The invention discloses a special growth regulator for pepper based on compounding of propionyl brassinolide and amino-oligosaccharin and application of the special growth regulator, and belongs to the technical field of agricultural biology. According to the regulating agent, 0.0008 to 0.0012 percent of propionyl brassinolide and 2.95 to 3.05 percent of amino-oligosaccharin are accurately matched with each other. The formula breaks through the contradiction between the root promotion requirement of high-dose amino-oligosaccharin and the safety threshold of low-dose brassinolide, and overcomes the phytotoxicity risk of the traditional dosage form. The regulator prepared by the invention can enhance the growth vigor of the pepper, improve the product and quality of the pepper, and also can effectively prevent viral diseases of the pepper.
Owner:KANGTUOSEN (ZHUMADIAN) BIOTECHNOLOGY CO LTD +1

Preparation method of mesenchymal stem cell exosome based on microcarrier three-dimensional culture and application of mesenchymal stem cell exosome in anti-aging skin care products

The invention discloses a preparation method of a mesenchymal stem cell exosome based on microcarrier three-dimensional culture and application of the mesenchymal stem cell exosome in anti-aging skin care products. According to the method, a three-dimensional culture system of mesenchymal stem cells is optimized, and the anti-aging function activity of the subsequently separated and purified exosome is remarkably improved by adopting a microcarrier with recombinant collagen as a main component; subsequently, by optimizing an exosome separation and purification technology, and through a specific separation and purification mode and conditions, the exosome with anti-aging active ingredients is further obtained. Experiments prove that the exosome obtained by the method disclosed by the invention can effectively remove metalloproteinase 1 and promote collagen regeneration, has a remarkable anti-aging effect, is suitable for essence, face cream and other dosage forms, and has a wide market prospect.
Owner:GUANGDONG REGEN-MED SCI & TECH LTD

Sublingual or buccal dosage forms comprising antioxidants for treatment of central nervous system disorders

Sublingual or buccal dosage forms comprise at least one antioxidant compound, such as N-acetyl cysteine (NAC), or a pharmaceutically acceptable salt thereof. The sublingual or buccal dosage forms are administered for treating central nervous system (CNS) disorders, such as traumatic brain injury or stroke.
Owner:BEYOND BARRIERS THERAPEUTICS INC

Double-dosage-form etching solution

The invention relates to the technical field of etching solutions, in particular to a double-agent type etching solution. Comprising the following components in percentage by weight: 10-15% of a first etching agent, 0.5-1% of a first regulator, 1-5% of a first stabilizer, 8-12% of a first complexing agent, 0.05-0.3% of a first inhibitor, 10-15% of hydrogen peroxide and the balance of water; the auxiliary agent comprises 40-60% of a second etching agent, 20-30% of a second complexing agent, 0.5-0.8% of a second inhibitor, 3-4% of a second stabilizer, 0.5-1% of a second conditioning agent and the balance of water. By limiting the formula content of the main agent, poor etching can be avoided, meanwhile, the content of the first regulator (phenylurea) is increased to 0.5 wt%, and the service life of copper is at least 14 kppm.
Owner:SICHUAN HESHENGDA ELECTRONIC TECH CO LTD +1

Traditional Chinese medicine and trace element composition capable of blacking hair and preventing hair loss as well as preparation method and application of traditional Chinese medicine and trace element composition

The invention relates to the technical field of compositions, and provides a hair-blacking and hair-loss-preventing traditional Chinese medicine and trace element composition and a preparation method and application thereof.The preparation method includes the steps that traditional Chinese medicinal materials with the effects of nourishing the liver and kidney, nourishing blood and growing hair are selected, and a multi-step water extraction and alcohol extraction combined technology is adopted to prepare high-purity traditional Chinese medicine extract dry powder; meanwhile, soluble trace elements such as zinc, iron and copper are selected, the optimal proportion of the soluble trace elements, the iron and the copper is determined through a response surface optimization algorithm, and a synergistic activity system is formed. Then, a mixture of traditional Chinese medicines and trace elements is dissolved in a buffer solution, and the mixture is entrapped in lipidosome composed of phospholipid and cholesterol through an ultrasonic nanocrystallization process, so that a stable nanoscale composite carrier is prepared; and finally, uniformly mixing the liposome suspension with a gel matrix to prepare the liposome gel dosage form for scalp external use. The problems of random component proportion, poor permeability and lack of mechanism verification in the prior art are solved.
Owner:NANYANG HAIZHIDA BIOTECHNOLOGY CO LTD

Pharmaceutical formulations containing therapeutic antibodies and uses thereof

Provided is a stable pharmaceutical formulation comprising a monoclonal antibody that specifically binds to human MASP-2 present in high and low concentrations, as well as a kit, a pharmaceutical composition, a unit dosage form, and a method for preparing the same. The invention also relates to a treatment method for inhibiting MASP-2-dependent complement activation and treating related diseases by using the preparation and the kit, the pharmaceutical composition and the unit dosage form, and application of the preparation and the kit, the pharmaceutical composition and the unit dosage form to prepare corresponding medicaments. Also provided are novel monoclonal antibodies that specifically bind to human MASP-2.
Owner:SUZHOU TRANSCENTA THERAPEUTICS CO LTD