659 results about "Nicotine" patented technology

The invention belongs to the field of buccal nicotine bags, and particularly relates to a buccal nicotine bag capable of releasing gas and a preparation method of the buccal nicotine bag. The buccal nicotine bag capable of releasing the gas comprises a bag body, nicotine powder and a gas releasing body, the nicotine powder and the gas releasing body are arranged in the bag body; the nicotine powder is in a pharmaceutically acceptable form suitable for oral delivery; the gas releaser releases gas when the buccal nicotine pouch is placed in the oral cavity. The gas release body releases gas in the oral cavity to give people a feeling similar to a jumping feeling, so that a sound similar to a crisp feeling is generated, and wonderful experience of taste and hearing is brought to consumers.

The invention provides a nicotine orally disintegrating tablet with a multi-layer composite sustained-release structure and a preparation method of the nicotine orally disintegrating tablet. The nicotine orally disintegrating tablet comprises an inner layer, a middle layer and an outer layer, wherein the middle layer and the outer layer sequentially coat the inner layer from inside to outside; the outer layer comprises nicotine, instant starch and a lubricant; the middle layer comprises nicotine, ethyl cellulose, polyethylene glycol and a flow aid; the inner layer comprises the following components: nicotine nanoparticles coated with chitosan and sodium tripolyphosphate, an oral microenvironment regulator and a filling agent. According to the nicotine orally disintegrating tablet provided by the invention, due to the gradient coating structure design of the inner layer, the middle layer and the outer layer, the multi-stage accurate release of nicotine, namely early-stage quick release, middle-stage stable release and later-stage slow release, is realized, the reactions of dizziness, vomiting and the like caused by excessive release of nicotine are avoided, and the use comfort is improved. Meanwhile, the pH value of the oral cavity is adjusted, micro-ecological balance of the oral cavity is maintained, the content of volatile sulfide in breath is reduced, and breath is refreshed.

The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.

An apparatus and method for an oral nicotine dispensing system. The apparatus includes storing a plurality of a pods in a magazine within a body, receiving a fingerprint scan from a user via a fingerprint scanner coupled to the body, authenticating the fingerprint scan, de-activating a locking mechanism to allow access to at least a pod upon successful authentication of the fingerprint scan, and dispensing, using at least a drive mechanism, the at least a pod from the magazine through an opening of the body.

The invention relates to a nicotine buccal bag with a content fixing cavity and a preparation method of the nicotine buccal bag. The nicotine buccal bag comprises a bag body, contents and a content fixing wall, the bag body is a saliva permeable bag; the content comprises a nicotine source and a functional capsule; the functional capsule comprises a shell and an inner core; the shell is saliva impermeable and is suitable for being destroyed by external force; the inner core comprises at least one of a pH regulator solution and a flavor provider solution; the content fixing wall and the bag body are relatively fixed, and a closed content fixing cavity is formed by the content fixing wall and the bag body; and a nicotine source and a functional capsule are accommodated in the content fixing cavity. The invention also relates to a preparation method of the nicotine buccal bag. The fixing cavity enables the functional capsule to have a certain and predictable position, and storage and use are convenient.

The invention belongs to the technical field of oral soluble film preparation, and relates to a preparation method for reducing nicotine oral soluble film irritation, which comprises the following steps: pretreating nicotine by adopting citric acid-sodium citrate buffer, and drying a film forming material, a functional soothing auxiliary material and a humectant to obtain the nicotine oral soluble film. Sequentially adding a nicotine buffer solution, a functional soothing auxiliary material, a humectant, a plasticizer and a sweetening agent into the film-forming material solution to prepare a film solution, defoaming, casting to form a film, drying in stages, cutting and packaging to obtain a nicotine oral soluble film finished product. The technical system of'triple synergy and mild release 'is constructed by adopting pH buffer regulation and control, functional auxiliary material synergy and composite material film forming, the prepared nicotine oral soluble film is remarkably reduced in irritation, high in nicotine stability and good in taste adaptability, the requirement of'immediate addiction' of novel tobaccos is met, instant stimulation caused by too fast release is avoided, and the nicotine oral soluble film is safe, compliant and suitable for large-scale popularization and application. The method is suitable for industrial mass production.

The present disclosure provides compositions and methods related to tobacco plants. In particular, the present disclosure provides novel methods for producing tobacco plants and any related tobacco product having low nicotine alkaloid content. The tobacco plants produced according to the methods of the present disclosure exhibit reduced levels of nicotine alkaloids (e.g., nicotine) as compared to naturally occurring and transgenic tobacco plants, and thus represent commercially valuable substitutes for currently available tobacco varieties.

1. The name of the design product: electronic atomization device. 2. The use of the design product: the design product is used for atomizing liquid containing nicotine to generate aerosol. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

An orally disintegrating nicotine tablet for fast nicotine craving relief is disclosed, the tablet comprising nicotine, disintegrant, and a filler, wherein the filler comprises no more than 10% by weight of sugar alcohol. Further, an oral nicotine tablet is disclosed, the oral nicotine tablet comprising the orally disintegrating nicotine tablet as a first module and further comprising a second module, wherein the second module is different in composition compared to the first module.

The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with mucic acid, 3,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid, and crystalline polymorphic forms of nicotine 4-acetamidobenzoate, nicotine gentisate, and nicotine 1-hydroxy-2-naphthoate are described. The invention further provides methods of preparation and characterization of such nicotine salts, co-crystals, and salt co-crystals and polymorphic forms thereof. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and / or salt co-crystals are also provided.

1. The name of the design product: electronic cigarette. 2. The use of the design product: the design product is used for heating and atomizing liquid matrix such as nicotine salt to generate aerosol for users to smoke. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention provides a nicotine releasing agent for buccal cigarettes and a preparation method and application of the nicotine releasing agent, and belongs to the technical field of tobaccos. The nicotine releasing agent for the buccal cigarette comprises cyclodextrin nanometer sponge with a three-dimensional porous nanometer structure and nicotine salt embedded and / or adsorbed and loaded on the cyclodextrin nanometer sponge, and cyclodextrin / cyclodextrin derivatives and a covalent cross-linking agent are subjected to a cross-linking reaction to form the cyclodextrin nanometer sponge.

A nicotine e-vaping device may include a device body configured to receive a nicotine cartridge. The nicotine cartridge includes a nicotine pre-vapor formulation, a wick, and an integral heater-thermocouple. The wick is configured to transport the nicotine pre-vapor formulation by capillary action. The integral heater-thermocouple includes a first segment made of a first alloy and a second segment made of a second alloy. The device body includes a power supply, at least one sensor, and a controller. The power supply is configured to deliver electrical energy to the integral heater-thermocouple to heat the nicotine pre-vapor formulation to generate a nicotine vapor. The at least one sensor is configured to measure a voltage difference between the first segment and the second segment of the integral heater-thermocouple during such heating. The controller is configured to adjust the electrical energy to the integral heater-thermocouple based on the measured voltage difference.

The invention relates to the technical field of waste smoke utilization, in particular to a method for preparing 2, 5-dihydroxypyridine based on biotransformation of crude nicotine, and the method comprises the following steps: S1, obtaining a genetic engineering strain for accumulating 2, 5-dihydroxypyridine by enabling an hpo gene in pseudomonas putida S16 not to be expressed; s2, culturing the genetic engineering strain obtained in the step S1 in a culture medium to obtain a thallus suspension serving as a biocatalyst; s3, enabling the thallus suspension obtained in the step S2 to be in contact with a substrate containing nicotine, and carrying out biotransformation reaction to generate the 2, 5-dihydroxypyridine. The method provided by the invention has the advantages of simpler reaction system, fewer by-products and easiness in product separation and purification when being used for preparing the 2, 5-dihydroxypyridine.

The invention relates to a nicotine bagged filling agent. The nicotine bagged filling agent comprises nicotine; a controlled release excipient comprising one or more selected from the group consisting of cellulose and sugar alcohols; a binder; a pH adjusting agent; and a perfume. Wherein the content of the nicotine is 2.5 wt% to 10 wt% of the weight of the total solid contents of the bagged filler for the nicotine, and the content of the controlled release excipient is 5.5 times to 36 times of the content of the nicotine.

To provide a nicotine electronic vaping device.SOLUTION: The nicotine e-vaping device 500 includes a nicotine reservoir, a heater 336, and processing circuitry. The processing circuitry is configured to determine a plurality of resistance values of the heater (336) during the time window, calculate a percent change in resistance of the heater (336) between the first plurality of resistance values and the second plurality of resistance values, determine whether the percent change in resistance of the heater (336) exceeds a percent change in resistance threshold, and disable power to the heater (336) in response to determining that the percent change in resistance of the heater (336) exceeds the percent change in resistance threshold.SELECTED DRAWING: Figure 8

The application discloses a pseudomonas strain TR14 and application thereof in degrading nicotine, and the pseudomonas strain TR14 is obtained by being separated from soil in which tobacco is planted perennially, has good degrading capacity on nicotine, and has a degrading rate of 98.44% on 7g / L nicotine after being cultured for 24 hours, and the highest tolerance reaches 8g / L nicotine. The strain can effectively degrade nicotine content in upper tobacco leaves.

The utility model discloses an electronic cigarette oil nicotine content determination device, including determination box, the determination box one side wall is installed with the circulating pipe, be provided with circulating pump on the circulating pipe, still be installed with detection tube on the circulating pipe, install detection sensor on the detection tube, detection sensor top end is installed with the determination appearance, install ultrasonic generator on the determination box back wall, install ceramic transducer board on the determination box inner one side wall. Advantageous effects lie in: the utility model discloses a set of by circulating pump and circulating pipe composition's circulating mechanism and will detection sensor set up on the circulating pipe, in the determination process, circulating pump makes the electronic cigarette oil that needs to determine circulating flow through the circulating pipe, and the detection sensor can determine the nicotine content of electronic cigarette oil in the electronic cigarette oil circulating flow process, and this mode can realize the comprehensive determination of electronic cigarette oil, and the detection range is wide, and the detection data precision is high, and has higher use performance.

Pouches are disclosed that can incorporate components in addition to consumables such as nicotine. Such components can include tooth whitening substances, oral antiseptics, gum or tooth health substances, vitamins, medicaments, and others. Such components can be provided within a pouch with the consumable, be impregnated into a pouch material, or be coated onto a pouch.

The invention relates to a method for reducing harmful components in cigarette smoke by using food-grade cyclodextrin metal organic framework materials, which is characterized in that two food-grade cyclodextrin metal organic framework materials CD-MOFs are added into cigarette filters for reducing the harmful components in the cigarette smoke. The unique pore structure and rich hydroxyl functional sites of the gamma-cyclodextrin-KOH and the beta-cyclodextrin-KOH are utilized to efficiently adsorb various harmful components in the mainstream smoke of the cigarette. Compared with a control group without any adsorbent and a control group with only activated carbon as the adsorbent, the CD-MOFs has efficient capturing capability on harmful gases such as carbon monoxide, nitrosonicotine, ammonia gas, benzo [a] pyrene and phenol in the cigarette smoke, and can obviously reduce the cigarette hazard index. The two materials are simple in preparation process, high in cost benefit and good in chemical stability, are food-grade porous materials and have incomparable practical application potential compared with traditional non-food-grade porous materials, and an effective solution is provided for developing novel low-harm cigarette products.

The invention provides a preparation method of high-purity nicotine. The content of nitroso substances in an obtained nicotine finished product is lower than the PPB level, and the content of single heavy metals such as lead, cadmium, mercury and hexavalent chromium is also lower than the PPB level. The low-content nitroso substance concentration and heavy metal concentration can effectively reduce the harm of the synthesized nicotine to the human body, and the method provided by the invention can realize continuous industrial production of nicotine, and fills the blank of the demand of the market for high-purity L-nicotine.

A method of controlling a heater (336) of a nicotine electronic vapor device (500) includes detecting, from a removable container (300) included in the nicotine electronic vapor device (500), power information indicative of a first power level and a second power level; and powering the heater (336) based on the detected power information by determining a first amount of electricity based on the first power level, supplying the first amount of electricity to the heater (336) during a first operating mode of the heater (336), determining a second amount of electricity based on the second power level, and supplying the second amount of electricity to the heater (336) during a second operating mode of the heater (336), the second amount of electricity being higher than the first amount of electricity.

The invention provides certain nicotine salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, certain nicotine salt-co-crystals are described, including nicotine and two different coformers. In addition, tobacco products, including smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and / or salt co-crystals are also provided.

A fluid dispenser for discharging a nicotine and / or cannabis-containing fluid as a replacement for tobacco products consumed by burning same, including a fluid store for storing the fluid before output, a mouthpiece for discharging the fluid, a connecting fluid channel and an outlet valve assembly, with which the fluid channel is opened and closed. The outlet valve assembly has an elastically deformable tube section forming part of the fluid channel, and an actuation surface is located on an outer side of the dispenser for actuating the outlet valve assembly. This actuation surface is coupled to a tube-shaping segment, with which the tube section is deformed from a state in which the fluid channel is closed into a state in which the fluid channel is open by applying force to the actuation surface, to thereby allow for the discharge of fluid.

Provided herein, according to an embodiment, is a nicotine-containing moist granulate composition comprising: nicotine or a pharmaceutically acceptable salt thereof; mannitol, and cellulose; the composition having a total moisture content of between 35-45%. The granulate shows favorable organoleptic qualities such as taste and mouthfeel and is free flowing to enable packaging in pouches. Optionally, the composition further comprises an oral health enhancing agent.

A nicotine pouched product is disclosed, the pouched product comprising a pouch composition and a saliva-permeable pouch enclosing said pouch composition, the pouch composition comprising nicotine and a pouch substrate, the pouch substrate comprising water-insoluble fiber, wherein said pouch composition comprises nicotine in an amount of at least 0.25% by weight of the pouch composition, and wherein the pouched product comprises said pouch composition in an amount of no more than 400 mg.

A liquid tobacco extract is provided, including: a non-aqueous solvent; at least 0.2 percent by weight of nicotine based on a weight of the liquid tobacco extract; and a ratio by weight of (β-ionone+β-damascenone) to (phenol) of greater than 0.25.

The invention relates to the technical field of electronic cigarettes, in particular to an electronic cigarette with a replaceable nicotine cigarette holder. The electronic cigarette comprises an oil bin, oil storage cotton, upper sealing silica gel, lower sealing silica gel and an atomizing core assembly. Oil storage cotton is arranged in the oil bin and is hollow to form an atomization channel. An atomizing core assembly is arranged in the atomizing channel; upper sealing silica gel and lower sealing silica gel are respectively arranged at the upper and lower ends of the oil storage cotton; the electronic cigarette further comprises a cigarette holder cover and a cigarette holder, the cigarette holder cover is connected to the upper portion of the upper sealing silica gel, and a cigarette holder containing cavity is formed corresponding to the atomization channel in a hollow mode. And a cigarette holder is inserted into the cigarette holder accommodating cavity. The requirements of different users can be met by replacing the cigarette holder; the method can be applied to electronic cigarettes.

A nicotine e-vaping device may include a device body configured to receive a nicotine cartridge. The nicotine cartridge includes a nicotine pre-vapor formulation, a wick, and an integral heater-thermocouple. The wick is configured to transport the nicotine pre-vapor formulation by capillary action. The integral heater-thermocouple includes a first segment made of a first alloy and a second segment made of a second alloy. The device body includes a power supply, at least one sensor, and a controller. The power supply is configured to deliver electrical energy to the integral heater-thermocouple to heat the nicotine pre-vapor formulation to generate a nicotine vapor. The at least one sensor is configured to measure a voltage difference between the first segment and the second segment of the integral heater-thermocouple during such heating. The controller is configured to adjust the electrical energy to the integral heater-thermocouple based on the measured voltage difference.

Disclosed herein are aldehyde dehydrogenase (ALDH-2) inhibitor compounds, such as a compounds of Formula (I) or Formula (II), pharmaceutical compositions comprising these inhibitor compounds, and uses of these compounds and compositions, such as in the methods for safely treating chemical dependency on a substance or condition of addiction, such as alcohol, nicotine, cocaine, opiates, amphetamines, and compulsive eating disorder, and / or anxiety disorder, each individually or concurrent.