1101 results about "Nicotine" patented technology

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a synthetic nicotine composition and a preparation method thereof. The nicotine buccal film agent disclosed by the invention is prepared from the following components in parts by weight: 2 to 4 parts of nicotine clathrate compound powder, 0.2 to 0.6 part of phosphatidic acid, 0.1 to 0.3 part of tannic acid, 0.1 to 0.2 part of sodium ascorbate, 0.04 to 0.06 part of tocopherol, 0.01 to 0.02 part of ethylene diamine tetraacetic acid, 2 to 4 parts of povidone and 40 to 80 parts of absolute ethyl alcohol. The synthesized nicotine composition prepared by the invention can effectively relieve the phenomenon that the faster the nicotine is released, the stronger the bitter taste is. Meanwhile, in a high-temperature and high-humidity environment, the stability of nicotine can be effectively maintained, and the oxidation half-life period of nicotine is prolonged.

The invention relates to a multi-chamber nicotine bag based on essence beads and pH regulator beads, the nicotine bag comprises nicotine powder, beads and a bag, the beads comprise essence beads and pH regulator beads, and the nicotine powder and the beads are packaged in the bag. The pouch may include at least two chambers, and the nicotine powder and the beads are encapsulated in different chambers. Compared with an existing nicotine bag, the nicotine bag has the advantages that the liquid essence and the pH regulator are independently wrapped in the condensate beads, so that volatilization of the essence and chemical inactivation caused by direct contact of the pH regulator and nicotine powder are avoided, and the storage life can be prolonged; and the prominent problems of local over-thick stimulation and insufficient overall release caused by uneven saliva wetting of a traditional nicotine bag are solved.

The invention discloses enterobacter hormaechei XW-01 and a microbial preparation thereof, the strain (preservation number is CCTCC NO: M 20242595) can efficiently degrade protein, total sugar and nicotine in tobacco leaves, sensory indexes such as aroma and aroma quantity are remarkably improved, and protease activity is remarkably improved when the enterobacter hormaechei XW-01 and wheat bran act synergistically. The microbial preparation is obtained through the processes of strain activation, fermentation culture and microbial agent preparation, and when the microbial preparation is applied to tobacco leaf treatment, through the steps of water content adjustment, preparation spraying, sealed fermentation, low-temperature drying and the like, the technical breakthrough that the protein content is reduced, the tar release amount is reduced, and the comprehensive quality grade is improved is achieved. Compared with a traditional method, the technology has the advantages that the treatment period is shortened, the cost is greatly reduced, the COD value of wastewater is greatly reduced, the cigarette quality and the production environmental protection property are remarkably improved, and the method has a wide industrial application prospect.

A spring-loaded nicotine pouch dispenser which enables users to access nicotine pouches quickly and easily. The nicotine pouch dispenser utilizes a dual-spring setup working in tandem underneath a plate to support the pouches and press them up to the body towards the opening. The retention prongs and semicircular cutout at the opening keep the pouches inline and secure from falling out while still being easy to access. The entire mechanism is encased in an outer body shell and a flip cap resulting in a completely sealed waterproof design that allows for easy, one-handed operation, eliminating the need for great strength or dexterity.

The invention discloses bacillus subtilis MY-01 as well as a microbial preparation and application of the bacillus subtilis MY-01. The strain (preservation number is CCTCC NO: M 20242596) can efficiently degrade cellulose, total sugar and nicotine in tobacco stems and remarkably improve sensory indexes such as aroma quality and aroma amount, and the cellulase activity is greatly improved when the strain and sodium carboxymethyl cellulose act synergistically. The microbial preparation is obtained through the processes of strain activation, fermentation culture and microbial agent preparation, and when the microbial preparation is applied to tobacco stem treatment, the technical breakthrough of reduction of the cellulose content, increase of the filling value and reduction of the tar release amount is achieved through the steps of water content adjustment, preparation spraying, sealed fermentation, low-temperature drying and the like. Compared with a traditional method, the technology has the advantages that the treatment period is greatly shortened, the cost is remarkably reduced, the COD value of wastewater is reduced, the cigarette quality and the production environmental protection property are remarkably improved, and the industrial application prospect is wide.

An apparatus and method for an oral nicotine dispensing system. The apparatus includes storing a plurality of a pods in a magazine within a body, receiving a fingerprint scan from a user via a fingerprint scanner coupled to the body, authenticating the fingerprint scan, de-activating a locking mechanism to allow access to at least a pod upon successful authentication of the fingerprint scan, and dispensing, using at least a drive mechanism, the at least a pod from the magazine through an opening of the body.

A nicotine e-vaping device includes a heater, a power control circuit, and a memory module. The heater element is configured to heat nicotine pre-vapor formulation. The power control circuit is coupled to the heater element through a wire. The power control circuit is configured to apply a pulse width modulated power signal to the heater element through the wire, and to receive information over the wire. The memory module is configured to detect a plurality of pulses in the pulse width modulated power signal, record information based on the detected plurality of pulses, and output the recorded information to the power control circuit via the wire.

The invention belongs to the field of buccal nicotine bags, and particularly relates to a buccal nicotine bag capable of releasing gas and a preparation method of the buccal nicotine bag. The buccal nicotine bag capable of releasing the gas comprises a bag body, nicotine powder and a gas releasing body, the nicotine powder and the gas releasing body are arranged in the bag body; the nicotine powder is in a pharmaceutically acceptable form suitable for oral delivery; the gas releaser releases gas when the buccal nicotine pouch is placed in the oral cavity. The gas release body releases gas in the oral cavity to give people a feeling similar to a jumping feeling, so that a sound similar to a crisp feeling is generated, and wonderful experience of taste and hearing is brought to consumers.

The invention provides a nicotine oral soluble film with a multi-layer structure, and belongs to the technical field of tobacco products. The nicotine oral soluble film with the multi-layer structure comprises a first film layer and a second film layer, wherein the first film layer comprises a first water-soluble polymer material and a nicotine release substance; the second film layer comprises a second water-soluble polymer material; wherein the first film layer and the second film layer are dissolved under the condition of being in contact with saliva, and the dissolving speed of the first film layer is higher than that of the second film layer.

A nicotine composition pouch, comprising a nicotine composition and a non-woven pouch for encapsulating the nicotine composition, wherein the nicotine composition comprises nicotine, sugar alcohol, a pH regulator, a filler, purified water, an adhesive, a humectant, a flavoring agent and a dispersing agent. The nicotine composition pouch further comprises a coating solution used for increasing the humidity of the nicotine composition. The nicotine composition pouch has a humidity of 30-50%. Before encapsulation, the nicotine composition has a particle size of ≤ 500 microns, a humidity of 10-30%, and a Carr's index of a bulk density of ≤ 20%. In addition, a preparation method for the nicotine composition pouch is provided. The nicotine composition pouch has a high level of humidity, good fluidity and a low preparation cost, and the preparation method for the nicotine composition pouch is simple, which can reduce the cost of a preparation device. Moreover, the nicotine composition pouch has a small filling quantity deviation, is easy to operate, and has a uniform content.

An apparatus and method for an oral nicotine dispensing system. The apparatus includes storing a plurality of a pods in a magazine within a body, receiving a fingerprint scan from a user via a fingerprint scanner coupled to the body, authenticating the fingerprint scan, de-activating a locking mechanism to allow access to at least a pod upon successful authentication of the fingerprint scan, and dispensing, using at least a drive mechanism, the at least a pod from the magazine through an opening of the body.

The invention provides a nicotine orally disintegrating tablet with a multi-layer composite sustained-release structure and a preparation method of the nicotine orally disintegrating tablet. The nicotine orally disintegrating tablet comprises an inner layer, a middle layer and an outer layer, wherein the middle layer and the outer layer sequentially coat the inner layer from inside to outside; the outer layer comprises nicotine, instant starch and a lubricant; the middle layer comprises nicotine, ethyl cellulose, polyethylene glycol and a flow aid; the inner layer comprises the following components: nicotine nanoparticles coated with chitosan and sodium tripolyphosphate, an oral microenvironment regulator and a filling agent. According to the nicotine orally disintegrating tablet provided by the invention, due to the gradient coating structure design of the inner layer, the middle layer and the outer layer, the multi-stage accurate release of nicotine, namely early-stage quick release, middle-stage stable release and later-stage slow release, is realized, the reactions of dizziness, vomiting and the like caused by excessive release of nicotine are avoided, and the use comfort is improved. Meanwhile, the pH value of the oral cavity is adjusted, micro-ecological balance of the oral cavity is maintained, the content of volatile sulfide in breath is reduced, and breath is refreshed.

The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.

There is provided a powder comprising a solid, porous chemically bonded ceramic system and nicotine or a salt thereof, wherein the nicotine or salt thereof is located within pores of the chemically bonded ceramic system. An intraoral formulation containing the powder may be held in the mouth where it releases the nicotine and contributes to providing an environment that facilitates nicotine uptake into the blood stream.

An oral pouch product includes a wrapper and a filling material. The wrapper defines a cavity. The filling material is in the cavity. The filling material includes a dry mixture and a liquid mixture. The dry mixture includes a cellulosic material and a water-soluble filler. The liquid mixture includes an oil and liquid nicotine. The oil includes a triglyceride, a diglyceride, a monoglyceride, or any combination thereof. The liquid nicotine is dissolved in the oil. The filling material is free of water or includes water in an amount less than or equal to 5 weight percent.

An apparatus and method for an oral nicotine dispensing system. The apparatus includes storing a plurality of a pods in a magazine within a body, receiving a fingerprint scan from a user via a fingerprint scanner coupled to the body, authenticating the fingerprint scan, de-activating a locking mechanism to allow access to at least a pod upon successful authentication of the fingerprint scan, and dispensing, using at least a drive mechanism, the at least a pod from the magazine through an opening of the body.

The invention relates to the technical field of nicotine oral delivery essence, and discloses a solid essence composition, solid essence prepared from the solid essence composition and application of the solid essence composition. The solid essence composition comprises the following components: a liquid essence base material, a water-soluble embedding medium and ethyl vanillin glucoside. The solid essence prepared from the solid essence composition can be used for preparing nicotine bags. The solid essence prepared from the solid essence composition provided by the invention is high in flavor stability; the prepared solid essence can still maintain the original flavor of the essence to a relatively high degree after being placed at high temperature and high pH for 12 hours; the overall stability of the solid essence is protected by adding ethyl vanillin glucoside and an embedding technology, so that the flavor, color and luster of the nicotine bag are improved.

Compositions and methods for genetically modifying the production levels of nicotine and other alkaloids in plants are provided.

The invention provides a preparation method of a nicotine load. The preparation method comprises the following steps: S1, preparing porous silicon dioxide; s2, mixing a first solution containing nicotine with porous silicon dioxide, and then drying to obtain a nicotine-silicon dioxide compound; s3, mixing a second solution containing polydopamine with the nicotine-silicon dioxide compound, and then washing and drying to obtain a polydopamine modified compound; s4, mixing a third solution containing trypsin substrate polypeptide with an activating agent to obtain a polypeptide activating solution; mixing a polypeptide activating solution with the polydopamine modified compound, and then washing and freeze-drying to obtain drug-loaded microspheres; and S5, mixing the drug-loaded microspheres with the temperature-sensitive gel, and dispersing the drug-loaded microspheres in the temperature-sensitive gel to obtain the nicotine load. The invention also provides a nicotine buccal product.

The invention relates to a nicotine buccal bag with a content fixing cavity and a preparation method of the nicotine buccal bag. The nicotine buccal bag comprises a bag body, contents and a content fixing wall, the bag body is a saliva permeable bag; the content comprises a nicotine source and a functional capsule; the functional capsule comprises a shell and an inner core; the shell is saliva impermeable and is suitable for being destroyed by external force; the inner core comprises at least one of a pH regulator solution and a flavor provider solution; the content fixing wall and the bag body are relatively fixed, and a closed content fixing cavity is formed by the content fixing wall and the bag body; and a nicotine source and a functional capsule are accommodated in the content fixing cavity. The invention also relates to a preparation method of the nicotine buccal bag. The fixing cavity enables the functional capsule to have a certain and predictable position, and storage and use are convenient.

The invention provides a nicotine-containing gel and a preparation method thereof. The nicotine-containing gel comprises the following components: a nicotine microcapsule, a penetrant, a gel matrix, a flavoring agent and water. The gel has excellent biocompatibility and slow release performance through combination of the nicotine microcapsules and the gel matrix, the skin permeability of nicotine can be improved by adding the penetrant, and the gel has the advantages of freshening the oral cavity and keeping fragrance for a long time by adding the flavoring agent. Therefore, a new consumption choice can be provided for smoking cessation groups and patients needing nicotine medicine.

The present invention discloses a nicotine-tartrate complex, a preparation method and an application, which relate to the technical field of chemical synthesis. The preparation method provided by the present invention includes: Step 1: Completely dissolve tartaric acid in a protic solvent to obtain a tartaric acid solution; Step 2: Dropwise add nicotine to the solution obtained in Step 1, and stir at room temperature until a white solid precipitates. Then, add an aprotic solvent to the reaction system, and the amount of the precipitated solid increases. Continue to stir for 16-24 hours. When the amount of the white solid no longer increases, filter, and wash the filter cake with the aprotic solvent 2-3 times to obtain a white solid; Step 3: Vacuum-dry the white solid obtained in Step 2 to obtain a white solid powder of tartaric acid-nicotine salt complex. This method well solves the problems that the nicotine-tartrate complex is not easy to form a solid and the solid is not easy to dry. The obtained nicotine-tartrate complex solid is a uniform white fluffy powder, which is more convenient to use.

This invention discloses a cigarette formulation design method based on calorific value adjustment. The method includes the following steps: S1, collecting calorific value data; S2, constructing a tobacco leaf calorific value prediction model based on near-infrared spectroscopy; S3, extending the model in step S2 to stockpiled tobacco leaves; S4, designing cigarette formulations based on calorific value screening; S5, improving the permeability and aroma of the formulation by selecting alternative formulations with significantly higher calorific values ​​than the original formulation; and improving the smoothness and reducing the irritation of the formulation by selecting alternative formulations with significantly lower calorific values ​​than the original formulation. This invention, without changing the basic components of the existing formulation, including total sugar, reducing sugar, nicotine, chlorine, potassium, total nitrogen, pH, etc., designs cigarette formulations of different styles and qualities by adjusting the calorific value, and achieves rapid detection of tobacco leaf calorific value.

The invention provides a buccal product and a preparation method thereof, and relates to the field of buccal products. The preparation method of the buccal product comprises the following steps: mixing an active substance with a porous carrier, so that the porous carrier adsorbs the active substance to obtain an active component load; in the process of preparing the active component load and / or after the active component load is obtained, auxiliary materials are added and mixed, and the buccal product loaded with the active substances is obtained. The form of the active substance comprises a solid state or a liquid state, and when the active substance is in the solid state, the ratio of the average particle size of the active substance to the average particle size of the porous carrier is less than or equal to 1: 2. By adding the porous carrier with a porous structure and high adsorbability, active substances including nicotine can be adsorbed, and effective fixation of the active substances is realized. In the preparation process, a heating process is not adopted, so that the volatilization loss of active substances is remarkably reduced, and the content and the stability of effective components of the product are improved.

An aerosol generating system includes an aerosol generating device including a first vaporizer configured to generate a first aerosol by heating a first liquid composition, a second vaporizer configured to generate a second aerosol by heating a second liquid composition, and a controller configured to control the first vaporizer and the second vaporizer, and an aerosol generating article accommodated in the aerosol generating device and indirectly heated by heat generated by the first vaporizer and the second vaporizer, wherein the controller is configured to control power supplied to the first vaporizer and the second vaporizer, based on a first mode, in which a smokeless aerosol is generated, and a second mode, in which a transport amount of nicotine included in the aerosol generating article is adjusted.

An Olive Tree Polyphenol and Lactobacillus Reuteri Compound for Rebalancing Oral Inflammation and Dysbiosis Associated with Consumers who use Tobacco industry products such as nicotine pouches is disclosed. These tobacco products tend to have a propensity to facilitate the colonization of pathogens in oral biofilms leading to negative side effects such as oral mucosal inflammation and dysbiosis. An object of the invention is to develop a composition to mitigate oral inflammation and restore a normal oral, microbial balance. This mixture includes olive polyphenols and Lactobacillus Reuteri. The composition can also be manufactured into various embodiment forms, including but not limited to: an oral spray; an effervescent tablet; a chewable tablet; a capsule; and a powder. Two empirical research experiments were carried out to verify efficacy of the composition.

The invention relates to the technical field of bioengineering, in particular to a process for continuously producing nicotine based on immobilized enzyme. The immobilized microbial agent comprises a composite carrier, an engineering strain and an immobilized auxiliary agent, in the process for continuously producing nicotine based on immobilized enzyme, amine oxidase of an engineering strain is subjected to site-specific modification, so that spatial structure deformation when the amine oxidase is combined with a carrier is reduced, and a three-dimensional network structure of hydroxyethyl chitosan-guar gum composite microspheres in the composite carrier is matched to provide an adaptive microenvironment; the activity loss of enzyme molecules caused by steric hindrance or structural change is reduced; in the immobilization auxiliary agent, gallic acid and an enzyme molecule sulfydryl form a coordinate bond to maintain an active center conformation, glutaraldehyde and polyethyleneimine enhance the binding stability through a crosslinking effect and charge regulation, and the maintaining effect of enzyme activity during continuous production is improved, so that the enzyme activity loss in the immobilization process is reduced, and the immobilization efficiency is improved. The stability of the enzyme in long-term continuous reaction is enhanced.

The utility model relates to a cigar smoke panel test auxiliary device. The cigar smoke panel test auxiliary device comprises a box body and an air generator, the box body comprises a detachable upper top cover, side walls and a lower bottom plate; a pipe body is arranged in an inner cavity of the box body; two ends of the pipe body are fixedly and tightly connected with the box body through nuts; and the like. When the cigar smoke panel is used, a sensory smoke panel test of multi-cigarette multi-dimensional comparison is carried out in a group, if cigars can be combusted for a long time, comparison in the group can be carried out at the same time, the cognitive burden and the taste memory requirement of smoke panel test personnel are reduced, and the cigar smoke panel test efficiency is improved. Meanwhile, by means of the design, smoke panel test personnel can smoke more cigarettes compared with smoke panel test personnel under the equivalent nicotine intake burden within the same time. The comparison purpose is achieved, the smoke panel test efficiency is improved, and a more accurate comparison conclusion is obtained. And meanwhile, the device is provided with a white cigarette ash collecting tray, so that the cigarette ash characters of the cigars can be compared after the cigars are smoked, and more intuitive combustibility evaluation can be obtained.

The invention belongs to the technical field of oral soluble film preparation, and relates to a preparation method for reducing nicotine oral soluble film irritation, which comprises the following steps: pretreating nicotine by adopting citric acid-sodium citrate buffer, and drying a film forming material, a functional soothing auxiliary material and a humectant to obtain the nicotine oral soluble film. Sequentially adding a nicotine buffer solution, a functional soothing auxiliary material, a humectant, a plasticizer and a sweetening agent into the film-forming material solution to prepare a film solution, defoaming, casting to form a film, drying in stages, cutting and packaging to obtain a nicotine oral soluble film finished product. The technical system of'triple synergy and mild release 'is constructed by adopting pH buffer regulation and control, functional auxiliary material synergy and composite material film forming, the prepared nicotine oral soluble film is remarkably reduced in irritation, high in nicotine stability and good in taste adaptability, the requirement of'immediate addiction' of novel tobaccos is met, instant stimulation caused by too fast release is avoided, and the nicotine oral soluble film is safe, compliant and suitable for large-scale popularization and application. The method is suitable for industrial mass production.

The present disclosure provides compositions and methods related to tobacco plants. In particular, the present disclosure provides novel methods for producing tobacco plants and any related tobacco product having low nicotine alkaloid content. The tobacco plants produced according to the methods of the present disclosure exhibit reduced levels of nicotine alkaloids (e.g., nicotine) as compared to naturally occurring and transgenic tobacco plants, and thus represent commercially valuable substitutes for currently available tobacco varieties.