1288 results about "Nicotine" patented technology

An electronic droplet delivery device having a mouthpiece of inhalation of droplets includes an aperture plate with a plurality of openings coupled to a piezoelectric actuator. A fluid reservoir supplies a solution with nicotine to the aperture plate for ejection out of the mouthpiece in a droplets stream.

An apparatus and method for an oral nicotine dispensing system. The apparatus includes storing a plurality of a pods in a magazine within a body, receiving a fingerprint scan from a user via a fingerprint scanner coupled to the body, authenticating the fingerprint scan, de-activating a locking mechanism to allow access to at least a pod upon successful authentication of the fingerprint scan, and dispensing, using at least a drive mechanism, the at least a pod from the magazine through an opening of the body.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a synthetic nicotine composition and a preparation method thereof. The nicotine buccal film agent disclosed by the invention is prepared from the following components in parts by weight: 2 to 4 parts of nicotine clathrate compound powder, 0.2 to 0.6 part of phosphatidic acid, 0.1 to 0.3 part of tannic acid, 0.1 to 0.2 part of sodium ascorbate, 0.04 to 0.06 part of tocopherol, 0.01 to 0.02 part of ethylene diamine tetraacetic acid, 2 to 4 parts of povidone and 40 to 80 parts of absolute ethyl alcohol. The synthesized nicotine composition prepared by the invention can effectively relieve the phenomenon that the faster the nicotine is released, the stronger the bitter taste is. Meanwhile, in a high-temperature and high-humidity environment, the stability of nicotine can be effectively maintained, and the oxidation half-life period of nicotine is prolonged.

An oral pouch product includes a wrapper and a filling material. The wrapper defines a cavity. The filling material is in the cavity. The filling material includes a dry mixture and a liquid mixture. The dry mixture includes a cellulosic material and a water-soluble filler. The liquid mixture includes an oil and liquid nicotine. The oil includes a triglyceride, a diglyceride, a monoglyceride, or any combination thereof. The liquid nicotine is dissolved in the oil. The filling material is free of water or includes water in an amount less than or equal to 5 weight percent.

The invention relates to a multi-chamber nicotine bag based on essence beads and pH regulator beads, the nicotine bag comprises nicotine powder, beads and a bag, the beads comprise essence beads and pH regulator beads, and the nicotine powder and the beads are packaged in the bag. The pouch may include at least two chambers, and the nicotine powder and the beads are encapsulated in different chambers. Compared with an existing nicotine bag, the nicotine bag has the advantages that the liquid essence and the pH regulator are independently wrapped in the condensate beads, so that volatilization of the essence and chemical inactivation caused by direct contact of the pH regulator and nicotine powder are avoided, and the storage life can be prolonged; and the prominent problems of local over-thick stimulation and insufficient overall release caused by uneven saliva wetting of a traditional nicotine bag are solved.

The invention discloses enterobacter hormaechei XW-01 and a microbial preparation thereof, the strain (preservation number is CCTCC NO: M 20242595) can efficiently degrade protein, total sugar and nicotine in tobacco leaves, sensory indexes such as aroma and aroma quantity are remarkably improved, and protease activity is remarkably improved when the enterobacter hormaechei XW-01 and wheat bran act synergistically. The microbial preparation is obtained through the processes of strain activation, fermentation culture and microbial agent preparation, and when the microbial preparation is applied to tobacco leaf treatment, through the steps of water content adjustment, preparation spraying, sealed fermentation, low-temperature drying and the like, the technical breakthrough that the protein content is reduced, the tar release amount is reduced, and the comprehensive quality grade is improved is achieved. Compared with a traditional method, the technology has the advantages that the treatment period is shortened, the cost is greatly reduced, the COD value of wastewater is greatly reduced, the cigarette quality and the production environmental protection property are remarkably improved, and the method has a wide industrial application prospect.

The invention provides atomized liquid. The atomized liquid is prepared from nicotine, cytisine and a solvent. By using the cytisine which has a synergistic effect with the nicotine, on the premise that the dosage of the nicotine is not increased, the atomized liquid which is better in satisfaction and better in tobacco addiction relieving effect is provided.

A spring-loaded nicotine pouch dispenser which enables users to access nicotine pouches quickly and easily. The nicotine pouch dispenser utilizes a dual-spring setup working in tandem underneath a plate to support the pouches and press them up to the body towards the opening. The retention prongs and semicircular cutout at the opening keep the pouches inline and secure from falling out while still being easy to access. The entire mechanism is encased in an outer body shell and a flip cap resulting in a completely sealed waterproof design that allows for easy, one-handed operation, eliminating the need for great strength or dexterity.

The invention discloses bacillus subtilis MY-01 as well as a microbial preparation and application of the bacillus subtilis MY-01. The strain (preservation number is CCTCC NO: M 20242596) can efficiently degrade cellulose, total sugar and nicotine in tobacco stems and remarkably improve sensory indexes such as aroma quality and aroma amount, and the cellulase activity is greatly improved when the strain and sodium carboxymethyl cellulose act synergistically. The microbial preparation is obtained through the processes of strain activation, fermentation culture and microbial agent preparation, and when the microbial preparation is applied to tobacco stem treatment, the technical breakthrough of reduction of the cellulose content, increase of the filling value and reduction of the tar release amount is achieved through the steps of water content adjustment, preparation spraying, sealed fermentation, low-temperature drying and the like. Compared with a traditional method, the technology has the advantages that the treatment period is greatly shortened, the cost is remarkably reduced, the COD value of wastewater is reduced, the cigarette quality and the production environmental protection property are remarkably improved, and the industrial application prospect is wide.

A nicotine e-vaping device includes a heater, a power control circuit, and a memory module. The heater element is configured to heat nicotine pre-vapor formulation. The power control circuit is coupled to the heater element through a wire. The power control circuit is configured to apply a pulse width modulated power signal to the heater element through the wire, and to receive information over the wire. The memory module is configured to detect a plurality of pulses in the pulse width modulated power signal, record information based on the detected plurality of pulses, and output the recorded information to the power control circuit via the wire.

An apparatus and method for an oral nicotine dispensing system. The apparatus includes storing a plurality of a pods in a magazine within a body, receiving a fingerprint scan from a user via a fingerprint scanner coupled to the body, authenticating the fingerprint scan, de-activating a locking mechanism to allow access to at least a pod upon successful authentication of the fingerprint scan, and dispensing, using at least a drive mechanism, the at least a pod from the magazine through an opening of the body.

A nicotine e-vaping device includes a heater, a power control circuit, and a memory module. The heater element is configured to heat nicotine pre-vapor formulation. The power control circuit is coupled to the heater element through a wire. The power control circuit is configured to apply a pulse width modulated power signal to the heater element through the wire, and to receive information over the wire. The memory module is configured to detect a plurality of pulses in the pulse width modulated power signal, record information based on the detected plurality of pulses, and output the recorded information to the power control circuit via the wire.

The invention belongs to the field of buccal nicotine bags, and particularly relates to a buccal nicotine bag capable of releasing gas and a preparation method of the buccal nicotine bag. The buccal nicotine bag capable of releasing the gas comprises a bag body, nicotine powder and a gas releasing body, the nicotine powder and the gas releasing body are arranged in the bag body; the nicotine powder is in a pharmaceutically acceptable form suitable for oral delivery; the gas releaser releases gas when the buccal nicotine pouch is placed in the oral cavity. The gas release body releases gas in the oral cavity to give people a feeling similar to a jumping feeling, so that a sound similar to a crisp feeling is generated, and wonderful experience of taste and hearing is brought to consumers.

The invention discloses a method for producing a green packaging material by using field planting tobacco waste, which comprises the following steps: by taking tobacco stems as raw materials, extracting to obtain high-purity nicotine, extracting active chemical components to obtain tobacco stem residues, primarily treating the residual tobacco stems by an extruding and tearing machine to cut off and separate the tobacco stems into shreds, and drying the shreds to obtain the green packaging material. The cut tobacco stems enter a closed reaction bin, steam heating is adopted, ammonium sulfite or sodium sulfite and sodium hydroxide are added, EDTA and the ammonium sulfite or sodium sulfite and sodium hydroxide solution can dissolve fibrous adhesive lignin in the tobacco stems, and the tobacco stems can be used for producing green packaging materials after further mechanical treatment. Tobacco stem waste residues obtained after nicotine and pectic substance extraction are used as plant fiber paper pulp for producing the green packaging material, holocellulose in the tobacco stem residues is fully recycled and subjected to high-value resource utilization, the waste recycling value is increased, and the problem of waste environmental pollution is solved.

The invention discloses a method for extracting nicotine-free tar from cigarette butts, which is applied to the field of cigarette butt recovery and comprises the following steps of: adding the cigarette butts into a 30L extraction kettle with a compression device, adding 6.32 kg of cigarette butts in total, adding ethanol, heating and extracting at 78 DEG C for three times, extracting for two hours at each time and 50.0 kg of ethanol in total, and concentrating an ethanol extracting solution to obtain 700.0 g of nicotine-containing tar with the extraction rate of 11% (in terms of cigarette butts). The method comprises the following steps: taking 429.9 g of nicotine-containing tar, adding 750ml of dichloromethane and 330ml of 1 equivalent diluted hydrochloric acid into the tar, stirring overnight at room temperature, adding dichloromethane into the solution, washing with water, and drying with anhydrous sodium sulfate to obtain 190.8 g of a nicotine-free tar product with the yield of 44.4% (metered by tar). According to the method, a feasible way is provided for recycling the effective components in the cigarette butts, after process parameters are further optimized, higher recycling efficiency and better economic benefits are achieved, meanwhile, pollution of the cigarette butts to the environment is reduced, and environmental protection is facilitated.

The invention belongs to the technical field of tobacco products, and particularly relates to nicotine slow-release aerogel based on bacterial cellulose as well as a preparation method and application of the nicotine slow-release aerogel. The nicotine slow-release aerogel comprises a graft-modified / ion-crosslinked bacterial cellulose network and a tobacco extract dispersed in the graft-modified / ion-crosslinked bacterial cellulose network, wherein the graft modified / ionic cross-linked bacterial cellulose network is used as an aerogel skeleton; the tobacco extract contains a target component nicotine which can be dissolved out and released from the target component nicotine after the aerogel swells in a saliva-like environment. Compared with a traditional buccal nicotine sustained-release product, the nicotine sustained-release aerogel is large in specific surface area, nicotine is derived from natural tobacco plants, and use of chemically synthesized nicotine is avoided. In addition, the nicotine slow-release aerogel is high in strength, good in biocompatibility, non-toxic, harmless, degradable and environment-friendly, and has important application value in the fields of buccal cigarettes, smokeless tobacco products, drug release and the like.

The invention provides a nicotine oral soluble film with a multi-layer structure, and belongs to the technical field of tobacco products. The nicotine oral soluble film with the multi-layer structure comprises a first film layer and a second film layer, wherein the first film layer comprises a first water-soluble polymer material and a nicotine release substance; the second film layer comprises a second water-soluble polymer material; wherein the first film layer and the second film layer are dissolved under the condition of being in contact with saliva, and the dissolving speed of the first film layer is higher than that of the second film layer.

The invention provides a nicotine oral soluble film containing coated pellets, and belongs to the technical field of tobacco products. The nicotine oral soluble film comprises a base layer and a coating pellet located in the base layer, wherein the coating pellet sequentially comprises an inner core, a slow release layer and a quick release layer from inside to outside; wherein the base layer, the slow release layer and the quick release layer respectively and independently comprise nicotine release substances; the base layer, the slow-release layer and the quick-release layer are dissolved under the condition of contacting with saliva, the dissolution rate of the quick-release layer is higher than that of the base layer, and the dissolution rate of the slow-release layer is lower than that of the base layer.

In various embodiments, novel hydrogels capable of releasing an active such as (S)-nicotine upon water absorption and swelling are described. In certain examples, hydrogels comprise (S)-nicotine, or a salt or a complex thereof, at least a polymer, at least a plasticizer and at least a disintegrant. In some embodiments, a hydrogel is utilized as the single delivery carrier for nicotine release. In other embodiments, hydrogel is composited with other carriers to form hydrogel-carrier combination fill materials usable for nicotine release. Hydrogels herein preferably comprise a polysaccharidic network or naturally occurring hydrogel-forming polymers plasticized for flexibility and including a disintegrant to accelerate decomposition of the hydrogel when used in the oral cavity of an individual for nicotine administration.

A nicotine composition pouch, comprising a nicotine composition and a non-woven pouch for encapsulating the nicotine composition, wherein the nicotine composition comprises nicotine, sugar alcohol, a pH regulator, a filler, purified water, an adhesive, a humectant, a flavoring agent and a dispersing agent. The nicotine composition pouch further comprises a coating solution used for increasing the humidity of the nicotine composition. The nicotine composition pouch has a humidity of 30-50%. Before encapsulation, the nicotine composition has a particle size of ≤ 500 microns, a humidity of 10-30%, and a Carr's index of a bulk density of ≤ 20%. In addition, a preparation method for the nicotine composition pouch is provided. The nicotine composition pouch has a high level of humidity, good fluidity and a low preparation cost, and the preparation method for the nicotine composition pouch is simple, which can reduce the cost of a preparation device. Moreover, the nicotine composition pouch has a small filling quantity deviation, is easy to operate, and has a uniform content.

An apparatus and method for an oral nicotine dispensing system. The apparatus includes storing a plurality of a pods in a magazine within a body, receiving a fingerprint scan from a user via a fingerprint scanner coupled to the body, authenticating the fingerprint scan, de-activating a locking mechanism to allow access to at least a pod upon successful authentication of the fingerprint scan, and dispensing, using at least a drive mechanism, the at least a pod from the magazine through an opening of the body.

The invention provides a nicotine orally disintegrating tablet with a multi-layer composite sustained-release structure and a preparation method of the nicotine orally disintegrating tablet. The nicotine orally disintegrating tablet comprises an inner layer, a middle layer and an outer layer, wherein the middle layer and the outer layer sequentially coat the inner layer from inside to outside; the outer layer comprises nicotine, instant starch and a lubricant; the middle layer comprises nicotine, ethyl cellulose, polyethylene glycol and a flow aid; the inner layer comprises the following components: nicotine nanoparticles coated with chitosan and sodium tripolyphosphate, an oral microenvironment regulator and a filling agent. According to the nicotine orally disintegrating tablet provided by the invention, due to the gradient coating structure design of the inner layer, the middle layer and the outer layer, the multi-stage accurate release of nicotine, namely early-stage quick release, middle-stage stable release and later-stage slow release, is realized, the reactions of dizziness, vomiting and the like caused by excessive release of nicotine are avoided, and the use comfort is improved. Meanwhile, the pH value of the oral cavity is adjusted, micro-ecological balance of the oral cavity is maintained, the content of volatile sulfide in breath is reduced, and breath is refreshed.

The invention provides reconstituted tobacco and a preparation method thereof and a heated cigarette, and the preparation method of the reconstituted tobacco comprises the following steps: step S1, classifying tobacco mixed raw materials to obtain tobacco stem raw materials, tobacco leaf raw materials and tobacco powder raw materials; s2, the tobacco stem raw materials, the tobacco leaf raw materials and the tobacco powder raw materials are treated, and a cellulose solution corresponding to the tobacco stem raw materials, tobacco powder corresponding to the tobacco leaf raw materials and a tobacco powder concentrated solution corresponding to the tobacco powder raw materials are obtained; and S3, mixing the cellulose solution, the tobacco powder and the tobacco powder concentrated solution, and carrying out drying forming treatment to obtain the reconstituted tobacco. Different components in the tobacco raw materials are screened and grouped through a reasonable process, optimized utilization of resources can be achieved, and the reconstituted tobacco sheets with higher nicotine and tobacco component content compared with an existing method are obtained.

The invention discloses a sustained-release nicotine buccal product and a preparation method thereof, the sustained-release nicotine buccal product comprises the following preparation raw materials: a microcapsule, a sustained-release auxiliary agent and a functional auxiliary agent, nicotine / salt and essence are embedded in the microcapsule, and the sustained-release auxiliary agent is a water-soluble polyhydroxy compound. The water-soluble polyhydroxy compound is used as the slow-release auxiliary agent, so that the loss rate of nicotine in the microcapsule can be greatly reduced, the release of nicotine in the use process is more lasting and uniform, meanwhile, the humidity of the product can be improved, the smoke is softer, the discomfort of the throat is reduced, and the smoking experience of a user is improved; besides, the humidity is improved, so that the release of nicotine can be promoted, the nicotine can be absorbed more easily, the stability of the nicotine can be improved, and the storage time of the product is prolonged.

The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.

The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in the method of treating a disease, disorder, or medical condition in a patient, comprising modulating myosin II ATPase, such as treatment of substance abuse relapse disorder, or of renal disease, cancer and metastasis, benign prostate hyperplasia, hemostasis or thrombosis, nerve injury including retinal damage, lung fibrosis, liver fibrosis, arthrofibrosis, wound healing, spinal cord injury, periodontitis, glaucoma and immune-related diseases including multiple sclerosis; or wherein the disease, disorder, or medical condition comprises addiction including abuse of or addiction to anything classified as a Substance-Related or Addictive Disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM), such as, but not limited to, cocaine, opioids, amphetamines, ethanol, cannabis / marijuana, nicotine, and activities including gambling.Compounds are of general formulawith substituents as defined herein.

The invention belongs to the technical field of enzyme engineering, and particularly relates to an enantioselectivity-improved imine reductase mutant and application thereof in production of S-nicotine, and the enantioselectivity-improved imine reductase mutant is obtained by performing single-point or multi-point mutation on the 118th site, the 168th site, the 169th site, the 172th site, the 234th site and the 238th site of the imine reductase with the amino acid sequence as shown in SEQ ID NO.2. According to the present invention, the imine reductase derived from Pseudomonas sp. RC4D1, the accession number of which is WP213665450.1 in NCBI is subjected to mutation to obtain a series of mutants, such that the high enzyme activity of the wild type imine reductase is maintained while the enantioselectivity in the S-nicotine catalytic preparation reaction is improved; compared with the prior art, the method has the advantages of simple production process, mild reaction conditions, high selectivity of imine reductase, high optical purity of the product and better industrial application prospect.

A drug resistant film is provided. The drug resistant film includes a drug contact sealing layer, an aluminum foil layer, a biaxially oriented polyamide layer, and a paper layer. The drug contact layer is configured to contact a drug, such as lidocaine, nicotine, or fentanyl. The aluminum foil layer is affixed to the drug contact sealing layer via a first lamination adhesive. The biaxially oriented polyamide layer is affixed to the aluminum foil layer via a second lamination adhesive. The paper layer is affixed to the biaxially orientated polyamide layer via a third lamination adhesive. According to an example, the drug contact sealing layer comprises an extruded monolayer of COC, EVOH, or PETG. According to an example, the drug contact sealing layer is a coextruded layer comprising a plurality of sublayers.

The invention provides a buccal product and a preparation method thereof. In the application, the buccal product comprises the sustained-release agent, the sustained-release agent comprises at least one of a beta-cyclodextrin inclusion compound of the nicotine derivative and carboxylate of the nicotine derivative, and the sustained-release agent can enable the nicotine derivative to be uniformly, slowly and durably released in the oral cavity, so that the residence time of the nicotine derivative in the oral cavity is prolonged; therefore, the buccal product can keep stable strength for a long time, long-acting and mild physiological satisfaction is provided for consumers, and irritation to digestive tracts can be effectively reduced.

There is provided a powder comprising a solid, porous chemically bonded ceramic system and nicotine or a salt thereof, wherein the nicotine or salt thereof is located within pores of the chemically bonded ceramic system. An intraoral formulation containing the powder may be held in the mouth where it releases the nicotine and contributes to providing an environment that facilitates nicotine uptake into the blood stream.