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33results about How to "Promote activation" patented technology

Battery pole piece and preparation method thereof, lithium ion battery and electric vehicle

PendingCN121862682ARealize the heating functionWill not affect charging and discharging efficiencyElectrode manufacturing processesSecondary cellsElectrical batteryManganese
The invention relates to the technical field of batteries, in particular to a battery pole piece, a preparation method of the battery pole piece, a lithium ion battery and an electric vehicle. The battery pole piece comprises a foil and an electrode material layer which are arranged in sequence, the material of the electrode material layer comprises manganese-cobalt-nickel oxide, the chemical general formula of the manganese-cobalt-nickel oxide is MnxCoyNizO, x is equal to 0.2-0.4, y is equal to 0.2-0.4, z is equal to 0.4-0.6, and x + y + z is equal to 1. The invention aims to improve the low-temperature performance of the battery without influencing the performance of the battery in a high-temperature environment.
Owner:ZHEJIANG GEELY HLDG GRP CO LTD +2

Cu nano-particle / acidified carbon nano-tube catalyst as well as preparation method and application thereof

The invention belongs to the technical field of electro-catalysis, and particularly discloses a Cu nanoparticle / acidified carbon nanotube catalyst and a preparation method and application thereof.According to the preparation method, acidified pretreated carbon nanotubes with good conductivity and high specific surface area are selected as a substrate, CuO nanoparticles are evenly loaded through a hydrothermal method, and the Cu nanoparticle / acidified carbon nanotube catalyst is obtained; and growing a zeolite imidazate framework material-8 (ZIF-8) on the surface of the CuO nanoparticle-loaded carbon nanotube in situ, and regulating the thickness of an ultrathin nitrogen-carbon layer on the surface and coordination of Cu-N by regulating the calcining temperature and time. According to the Cu nanoparticle / acidified carbon nanotube catalyst as well as the preparation method and the application thereof, the Cu nanoparticles are encapsulated in a confined manner, so that long-service-life electrically-driven CO2 is converted into a high-added-value C2 + product, catalytic active sites of the Cu nanoparticles are fully exposed, the charge transfer rate is increased, and the intrinsic activity of the Cu active sites is improved.
Owner:ZHEJIANG UNIV

Ldh-based vaccine adjuvant, and preparation method and application thereof

The application discloses an LDH-based vaccine adjuvant and a preparation method and application thereof, and belongs to the technical field of aluminum adjuvant preparation of vaccines, and the preparation method comprises the following steps: mixing at least one of soluble magnesium salt, soluble zinc salt, soluble manganese salt and soluble calcium salt with soluble aluminum salt, and then performing a co-precipitation reaction with a sodium hydroxide aqueous solution in a colloid mill device, and performing crystallization to obtain LDH nanosheets; dispersing the LDH nanosheets in a PBS solution, adding a hepatitis B surface antigen molecule drug, uniformly mixing, and then performing centrifugation to obtain the LDH-based vaccine adjuvant. The LDH-based vaccine adjuvant can significantly promote the maturation of DC cells and the activation of T cells, and the total IgG level reflects the overall humoral immune response intensity of the body to vaccines or pathogens; the LDH-based vaccine adjuvant forms a "storage library" at an injection site to store antigens and slowly release the antigens, and the purpose of long-time continuous stimulation of the immune system in the body is achieved.
Owner:BEIJING UNIV OF CHEM TECH

Synthetic method of indoloquinazolinone compound

The invention relates to a synthetic method of an indoloquinazolinone compound. The synthetic method comprises the following steps: reacting 2-aminoacetophenone with aryl isocyanate under the catalytic action of a palladium complex to obtain the indoloquinazolinone compound, wherein the palladium complex is an N, N-coordinated palladium complex containing a meta-carborane ligand. The preparation process of the palladium complex comprises the following steps: adding an n-BuLi solution into a meta-carborane solution to carry out a deprotonation reaction, then adding 3-chloromethylpyridine to carry out a nucleophilic substitution reaction, finally adding Pd (OAc) 2 to carry out a coordination reaction to obtain a palladium complex head product, and carrying out post-treatment to obtain the palladium complex product. Compared with the prior art, the method disclosed by the invention has the advantages of good adaptability, high catalytic efficiency, few byproducts, mild reaction conditions, lower cost, easiness in product separation, no generation of a large amount of waste residues and the like.
Owner:SHANGHAI INST OF TECH

A selective activation-based spiking neural network continuous learning target recognition system

The application discloses a kind of based on selective activation's pulse neural network continuous learning target identification system, including computer memory, computer processor and the computer program stored in the computer memory and can be executed on the computer processor, the computer memory has the selective activation SNNs model of well-trained;Selective activation SNNs model includes the feature extraction part of pulse neural network front end, and trajectory-based K-WTA mechanism and variable threshold mechanism are used in rear end to carry out continuous learning;The computer processor executes the computer program and realizes the following steps: the image to be identified is input into well-trained selective activation SNNs model, and the identification classification result is obtained.The present application reduces the catastrophic forgetting by enhancing the neural dynamic characteristics in intelligent learning network (SNN), improves the target recognition effect of pulse neural network in continuous learning scene, and expands the application scene of pulse neural network.
Owner:ZHEJIANG UNIV

A full deep sea eight-element aluminum alloy sacrificial anode and a preparation method thereof

ActiveCN118932339Bpromote sheddingDissolves evenly on the surface
This invention belongs to the field of metal material corrosion protection technology, specifically relating to a highly active aluminum alloy sacrificial anode for full ocean depth and its preparation method. The sacrificial anode uses Al as the main raw material, with added alloying elements: Zn, In, Ga, Mg, Ti, Ca, and Mn. The preparation method involves first heating Al and Zn to 750–1000℃, then adding In, Ga, Mg, Ti, Ca, and Mn, and finally casting at a temperature of 700–750℃. By adding Ca, an octet aluminum alloy sacrificial anode for full ocean depth is formed. The activation ability is improved by the dissolution and redeposition of In and Ga, the disruption of the continuity and density of the oxide layer by Zn and Mg, and the activation of the Al matrix surface by micron-level dot pairs. At the same time, Ti refines the grain size, resulting in a uniform and segregated distribution of alloying elements, avoiding internal self-corrosion, and improving current efficiency. It can be applied to full ocean depth environments from 0 to 10000 meters, with a current efficiency of 90–95%.
Owner:CHINA SHIPBUILDING INDUSTRY CORPORATION NO725 RESEARCH INSTITUTE

A method for extracting alumina from an industrial solid waste red mud

PendingCN122540907AImprove leaching effectpromote generation
The application discloses a method for extracting alumina from industrial solid waste red mud. The method comprises the following steps: mixing the red mud with a composite additive composed of sodium carbonate, potassium sulfate and limestone, wet ball milling the mixture until the particle size of the mixture reaches D90≤74 μm, drying the obtained slurry until the water content is less than 5%, and sintering at 950-1050 ℃ to obtain sintered clinker; leaching and separating the sintered clinker in hot water at a liquid-solid ratio of 10:1-25:1 and at 65-95 ℃ to obtain an aluminum-containing filtrate; introducing CO2 into the filtrate to perform carbonization, and performing aging and solid-liquid separation to obtain aluminum hydroxide; and then performing washing, drying and calcination to obtain an alumina product. By introducing potassium sulfate as a fluxing agent, the transformation of inert aluminum mineral phases is promoted, the sintering temperature can be reduced by 50-100 ℃, the time can be shortened by 30-50%, the process energy consumption is low, the aluminum extraction efficiency is as high as 88% or more, and a brand-new path is provided for large-scale resource utilization of the red mud.
Owner:SOUTH CHINA UNIV OF TECH

ACLY-targeting oligopeptide and application thereof in bacterial infection

ActiveCN121974978APromote activationImprove defenseAntibacterial agentsPeptide/protein ingredientsDiseaseVirtual screening
The invention discloses an ACLY-targeting oligopeptide and application thereof in bacterial infection, and belongs to the technical field of biological medicines. Three candidate peptides are obtained through molecular docking, virtual screening and the like, and it is found through experiments that the candidate peptide PVP can destroy ACLY-NLRP3 interaction and promote NLRP3 inflammasome activation, and the defense capacity of a host to bacterial infection is enhanced. The invention discloses a self-limiting loop of immune-metabolism cross dialogue, the ACLY-NLRP3 axis is positioned as a new therapeutic target of inflammasome driven diseases, and meanwhile, a new short peptide is provided for treating bacterial infection.
Owner:SHANDONG UNIV

Myocardial microvascular perfusion auxiliary system

The invention discloses a myocardial microvascular perfusion auxiliary system. The myocardial microvascular perfusion auxiliary system comprises a guide sheath and a balloon catheter device. The balloon catheter device comprises a catheter, and a balloon and a connector are arranged on the catheter. The catheter is provided with a center channel, a gas channel and an air pressure measuring channel, the center channel is through and communicated with the first blood pressure sensor through the connector and the first pressure measuring extension pipe, and the gas channel is communicated with the interior of the balloon and the connector and communicated with the gas driving module through the gas conveying pipe. The air pressure measuring channel is communicated with the interior of the balloon and the connector and communicated with the pressure sensor through the air pressure measuring pipe. The guiding sheath is communicated with the second blood pressure sensor through the pressure measuring connector via the second pressure measuring extension tube. Pressure measuring chips in the first blood pressure sensor, the pressure sensor and the second blood pressure sensor are connected with the signal acquisition module, and the signal acquisition module and the gas driving module are connected with the control module. The balloon provided by the invention can effectively reduce the risk of vascular wall injury and thrombosis caused by complete occlusion of coronary sinus.
Owner:CHINESE ACADEMY OF MEDICAL SCIENCES FUWAI HOSPITAL SHENZHEN HOSPITAL (SHENZHEN SUN YAT-SEN CARDIOVASCULAR HOSPITAL)

Preparation method of high-dispersion copper-based catalyst and application of high-dispersion copper-based catalyst in preparation of CHDM

PendingCN121945092AImprove basic sitesIncrease oxygen vacancy contentOrganic compound preparationHydroxy compound preparationPtru catalystManganese
The invention relates to the technical field of catalyst preparation, and discloses a preparation method of a high-dispersion copper-based catalyst and application of the high-dispersion copper-based catalyst in preparation of CHDM, the preparation method comprises the following steps: (1) adding a copper salt, a manganese salt, an aluminum salt and a rare earth metal salt into water, and dissolving to obtain a mixed salt solution; sodium hydroxide and sodium carbonate are added into water to be dissolved, and a mixed alkali solution is obtained; (2) reacting the mixed salt solution and the mixed alkali solution in a micro-liquid membrane reactor, after the reaction is completed, carrying out crystallization reaction on the obtained suspension, and then centrifuging and drying to obtain a quaternary hydrotalcite precursor; and (3) roasting and reducing the quaternary hydrotalcite precursor to obtain the copper-based catalyst. According to the copper-based catalyst, Cu nanoparticles are highly dispersed on the surface of a composite metal oxide, the copper-based catalyst is applied to 1, 4-cyclohexanedicarboxylic acid dimethyl ester reaction hydrogenation for preparing 1, 4-cyclohexanedimethanol, excellent catalytic activity and stability are shown, and CHDM has a high trans-cis ratio.
Owner:ZHEJIANG HENGYI PETROCHEMICAL RES INST CO LTD

Functional fascia gun head

This invention provides a functional fascia gun head, belonging to the field of massage devices and physical therapy technology. This functional fascia gun head consists of a power-generating layer and a regular fascia gun head; the power-generating layer can be placed outside or inside the regular fascia gun head. Another design of the functional fascia gun head is entirely composed of a power-generating layer. When the fascia gun is in operation, the power-generating layer generates a Maxwell pulse electric field and a pulse displacement field current under force, forming a pulse wave. This pulse wave can effectively penetrate multiple layers of skin structure, promoting blood circulation and cell activation, achieving various health benefits such as warming the meridians and activating collaterals, relaxing muscles, relieving pain, preventing injury, dispelling cold and dampness, harmonizing yin and yang, promoting homeostasis, and delaying aging. The power-generating layer is made of various materials and has various structural forms; the manufacturing process is simple, significantly improving the product's multifunctionality and ease of use, providing more diversified and efficient options for the medical and beauty fields.
Owner:王珏

Supported Bimetallic Two-Dimensional Nanocatalytic Materials and Preparation Methods and Applications

The present application discloses a supported bimetallic-based two-dimensional nanocatalytic material, a preparation method thereof, and an application thereof, which relate to the technical field of catalysts. The preparation method includes: preparing a plasma nanosheet with a single-layer structure or a few-layer structure; dispersing the plasma nanosheet in a solvent and adding a copper source to prepare a first mixed solution; subjecting the first mixed solution to stirring treatment in an inert gas environment, and successively performing freeze-drying treatment and calcination treatment in a hydrogen atmosphere to prepare a nanosheet-Cu; successively adding HAuCl4 and HCl to the nanosheet-Cu, mixing and reacting under a preset light condition to prepare a supported bimetallic-based two-dimensional nanocatalytic material, namely, a nanosheet-Cu-Au. The present application can achieve the functional division and spatial synergy of bimetallic active sites, and promote the efficient generation, separation, and directional transport of photo-generated carriers, thereby improving the reaction efficiency and product selectivity of the co-reduction of nitrate and carbon dioxide to urea.
Owner:SUZHOU UNIV

A goaf filling cementitious material, a filling test block and a preparation method thereof

ActiveCN117843259Bmass consumptionStable consumptionMaterial fill-upSlagMining engineering
The application discloses a kind of goaf filling cementitious material, filling test block and preparation method thereof, and the mass ratio of the goaf filling cementitious material is as follows: stone coal vanadium extraction tailings 50-70%, stone coal vanadium extraction neutral residue 5-20%, smelting slag 0-15%, cement clinker 10-30%, and activator 2-8%.The filling test block also includes full tailings filling material and tap water, the mass percentage of the tap water is 18-30%, and the mass ratio of the goaf filling cementitious material to the full tailings filling material is 1:12-1:4.The goaf filling cementitious material uses stone coal vanadium extraction tailings as the main raw material, can be applied to mine tailings filling nearby, helps to large-scale, stable absorption of vanadium tailings, avoids the problems caused by tailings accumulation, and has a positive effect on the green development of mine and the friendly development of mining industry and social environment.The preparation method of the goaf filling cementitious material is simple, the main raw materials used can be obtained nearby, which helps to reduce the production cost of the cementitious material.
Owner:XIAN NORTHWEST INST OF NONFERROUS GEOLOGY CO LTD

A membrane coupling-based complexed copper wastewater treatment system and method

This invention discloses a membrane coupling-based system and method for treating copper complex wastewater. The method includes: S1 pre-oxidation and complex-breaking treatment; S2 adding a heavy collector to the wastewater and performing cross-flow filtration using a membrane separation device equipped with an electrochemically activated membrane module to obtain a concentrated solution of the heavy collector-copper complex; S3 adjusting the pH of the concentrated solution and performing secondary filtration using the same membrane separation device, retaining the heavy collector for reuse, with the permeate being an acidic solution containing free copper ions; S4 chemically depositing and separating the acidic copper-containing solution to recover copper. In the S2 enrichment stage, a reducing electric field is applied using the membrane as the cathode, and in the backwashing stage, an oxidizing electric field is applied as the anode. The heavy collector is a graft copolymer or terpolymer of polyacrylic acid and β-cyclodextrin, which forms a loose, porous gel layer on the membrane surface during enrichment and naturally peels off. This invention achieves efficient complex breaking of copper complexes, high-purity recovery of copper resources, recycling of the heavy collector, and effective control of membrane fouling.
Owner:JIANGSU SAFELY ENVIRONMENT ENG

Method for one-step production of ethylbenzene from ethane and benzene by alternating electromagnetic field and catalyst thereof

PendingCN122583009APromote activationSelective synergy improvement
The application provides a method for preparing ethylbenzene from ethane and benzene by an alternating electromagnetic field and a catalyst thereof. The method comprises the following steps: introducing a reaction gas containing ethane and benzene into a reactor filled with a metal-molecular sieve bifunctional catalyst, and applying an alternating electromagnetic field. The magnetic heating effect of the magnetic metal component (such as Fe, Co and Ni) in the catalyst is utilized to realize directional heating, drive the cooperative reaction of ethane dehydrogenation and benzene alkylation, and generate ethylbenzene in one step. The catalyst is composed of magnetic metal nanoparticles and a molecular sieve (such as ZSM-5). The application solves the problem that the reaction temperatures of the endothermic dehydrogenation and the exothermic alkylation are not matched in the prior art, simultaneously utilizes the non-thermal effect induced by the magnetic field to enhance hydrogen overflow and inhibit carbon deposition, realizes the cooperative improvement of the benzene conversion rate and the ethylbenzene selectivity, and has the advantages of a short process, high energy efficiency and good catalyst stability.
Owner:NORTHWEST UNIV

Preparation method and application of eucalyptus cellulose carbon-loaded monatomic catalyst

The invention discloses a preparation method of a eucalyptus cellulose carbon-loaded monatomic Ir catalyst, which comprises the following steps: by taking delignified eucalyptus cellulose as a raw material, pyrolyzing in an inert atmosphere at 600-900 DEG C to prepare a carrier material, and then loading metal Ir on the carrier material to prepare the carbon-loaded monatomic catalyst IrSACs / C; the catalyst is applied to hydrodeoxygenation reaction of aldehyde compounds or ketone compounds, and has the characteristics of mild reaction conditions, high selectivity and excellent cycle stability. Compared with the prior art, the catalyst prepared by the method provided by the invention has the characteristics of high specific surface area and low Ir loading capacity, and the Ir can realize atomic-scale dispersion on the carrier; the catalyst is wide in raw material source and simple in preparation method, and a new way is provided for simple synthesis of an efficient monatomic catalyst for biomass hydrodeoxygenation under mild conditions.
Owner:SOUTHWEST FORESTRY UNIVERSITY

An injectable photocured hydrogel for anti-inflammatory pro-angiogenic tissue regeneration

ActiveCN119367599Bfast preparationGood shear thinning propertiesP phosphateBlood vessel
This invention discloses an injectable photocurable hydrogel with anti-inflammatory and pro-angiogenic tissue regeneration properties, belonging to the field of biomedical materials technology. The hydrogel is a methacrylic anhydride-modified gelatin hydrogel loaded with calcium phosphate oligomers and sulfur quantum dots. Its preparation method involves dissolving methacrylic anhydride-modified gelatin in a phosphate buffer solution, then adding calcium phosphate oligomers and sulfur quantum dots, followed by adding a photoinitiator and mixing thoroughly. Finally, it is cured under ultraviolet or blue light irradiation. This invention also discloses the application of the injectable photocurable hydrogel with anti-inflammatory and pro-angiogenic tissue regeneration properties in the preparation of products for treating infected bone defects. This hydrogel can release the bioactive components of sulfur quantum dots and calcium phosphate oligomers in situ, synergistically promoting the healing of infected bone defects through multiple effects including antibacterial, immunomodulatory, angiogenesis, and osteoproliferative effects.
Owner:SICHUAN UNIV +1

5G network slice pre-arrangement method, device, equipment, medium and product

The invention discloses a 5G network slice pre-arrangement method and device, equipment, a medium and a product, and the method comprises the steps: determining a predicted access base station track and a target service request type of each user terminal in a pre-arrangement time period based on the historical access base station track information of each user terminal; and performing network slice arrangement based on the predicted access base station trajectory and the target service request type to obtain at least one pre-arrangement network slice in the pre-arrangement time period. According to the invention, the preparation work of the 5G network slice can be completed in advance, the configuration efficiency of the 5G network slice and the adaptability under high load or burst flow are improved, the 5G network slice can be rapidly activated when the user demand changes, and different network resource configurations can be rapidly switched.
Owner:CHINA MOBILE INTERNET CO LTD +1

A protein nanoparticle with deformability and dual targeting ability in response to pH and a preparation method and application thereof

The application discloses a pH-responsive deformable double-targeting nano-protein and a preparation method and application thereof, and the method comprises the following steps: after carboxylated mannose is activated through an EDC / NHS system, the carboxylated mannose is reacted with an albumin solution, and mannose-modified albumin is obtained through dialysis purification; the mannose-modified albumin is mixed with an inhibitor IRG1-IN-1, and IRG1-IN-1 is loaded through hydrophobic interaction to obtain mannose albumin nanoparticles; ferritin is used as a carrier, and oxaliplatin is loaded through a solvent displacement method to obtain ferritin nanoparticles; CHO-PEG2k-CHO is used as a connecting agent, and the mannose albumin nanoparticles and the ferritin nanoparticles are crosslinked through a Schiff base reaction to form large-size pH-responsive double-targeting nano-proteins. The double-targeting separable characteristics of the nano-proteins can realize specific treatment, kill tumor cells, interfere with immune cell metabolism, block metabolic immunosuppression, and promote anti-tumor immunotherapy.
Owner:WUHAN UNIV

Energy-saving process for activating biochar with wood vinegar vapor by thermo-chemical-physical coupling method

The application discloses an energy-saving process for activating biochar by wood vinegar steam through a thermo-chemical-physical coupling method, wherein wood vinegar steam is used as an activating agent instead of water vapor, and wood vinegar liquid is recycled in the process, serving as a heat carrier and participating in a thermo-chemical reaction to release heat, so that energy is saved and emission is reduced, and the process is a green new process, energy saving over 60%, wood vinegar liquid utilization rate 100%, and no waste liquid discharged. Due to the ionization of acetic acid, a characteristic component, the process also meets the swelling action principle of acid activation, so that biochar is more easily activated, and has double effects, and is a thermo-chemical-physical coupling method. The wood vinegar liquid generated in the biochar process is used as an activating agent, so that the problems of high energy consumption of a single water vapor activation method and chemical pollution of a single phosphoric acid activation method are avoided. The process overcomes the shortcomings of traditional methods, saves energy and reduces emission, reduces production cost, and effectively realizes comprehensive utilization of wood vinegar liquid.
Owner:CHUZHOU JINCHUN BIOTECHNOLOGY CO LTD

A method for efficiently extracting starch from green mung bean

The application relates to the field of biochemical technology, and particularly discloses a method for efficiently extracting green mung bean starch. The method comprises the following steps: obtaining green bean sprouts by ultrasonic-assisted soaking and germination culture of green mung beans; obtaining green bean sprout powder by drying, crushing and sieving the green bean sprouts; mixing the green bean sprout powder with a NaOH solution, oscillating, washing, centrifuging, filtering and obtaining pure starch, and finally drying, grinding and sieving to obtain germinated green mung bean starch. The extraction method combines ultrasonic pretreatment with a germination process, effectively improves the gelatinization characteristics of the starch, significantly improves the starch viscosity, thereby enhancing the applicability of the starch in food processing, and meanwhile, the nutritional and functional characteristics of the green mung bean starch are retained.
Owner:QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES) +1

Biomass-based activated carbon and method for preparing the same

The application discloses a biomass-based activated carbon and a preparation method thereof, and belongs to the technical field of activated carbon materials. The biomass-based activated carbon is prepared from 7-8 parts of crop residues and 1.5-2.5 parts of dried sponge gourd core as carbon-based solid materials, and is prepared through the steps of soaking in an activated water solution, microwave hydrothermal treatment carbonization and twice physical activation treatment. The biomass-based activated carbon has the characteristics of higher specific surface area, more abundant pore structure and surface functional groups, and excellent adsorption capacity. In the whole preparation process, the production raw materials are green and safe, waste gas resources are reused, the environment is protected, and the corrosion of the raw materials to the production equipment is small. The biomass-based activated carbon is suitable for popularization and application in the fields of food processing and pharmaceutical manufacturing.
Owner:XUZHOU HUARUI CARBON MATERIAL TECH CO LTD

Application of Sema3E inhibitor in preparation of medicine for preventing, delaying or treating COPD small airway fibrosis

PendingCN121944115APromote activationIncreased proliferationOrganic active ingredientsRespiratory disorderSmall airwaysCOPD
The invention belongs to the technical field of biological medicines, discloses an application of a Sema3E inhibitor in preparation of a medicine for preventing, delaying or treating COPD small airway fibrosis, and proposes that the Sema3E inhibitor can be used for treating, preventing or delaying the COPD small airway fibrosis for the first time. The Sema3E inhibitor plays a role by inhibiting the expression of Sema3E. The specific molecular mechanism is as follows: by inhibiting the expression of Sema3E, inhibiting the expression of Wnt5a / b, beta-Catenin, increasing the expression of p-beta-Catenin, inhibiting the activation of a Wnt / beta-Catenin pathway, and inhibiting the activation / proliferation / migration of small airway fibroblasts. Through the mechanism, the effect of preventing, delaying or treating the COPD is achieved, and a new drug intervention target, namely Sema3E, is provided for treatment of the COPD.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Application of Pomalidomide in preparation of medicine for long-term immune reconstitution of HIV (Human Immunodeficiency Virus) patient

PendingCN121796397APromote activationreduce exhaustOrganic active ingredientsAntiviralsActivation cellsPharmaceutical drug
The invention discloses an application of Pomalidomide in preparation of a medicine for long-term immune reconstitution of an HIV (human immunodeficiency virus) patient. According to the application disclosed by the invention, the research finds that pomalidomide can be used for remarkably inhibiting the replication of HIV-1 in MT-4 and Jurkat cell lines, primary CD4 + T cells and humanized mouse models for the first time, and the Pomalidomide can be used for increasing the quantity of CD4 + T and the ratio of CD4 to CD8, increasing the activation of T cells, reducing the depletion of the T cells and promoting immune reconstruction no matter in a cell model or a mouse model. The invention provides a theoretical basis for research and development of medicines for long-term immune reconstitution of HIV patients, opens up a new application of Pomalidomide, provides a brand new method for treating HIV infection and promoting long-term immune reconstitution of HIV patients, and has a wide application prospect in the technical field of treatment of HIV infection.
Owner:JILIN UNIVERSITY

A high-sulfur-content isobutylene sulfide production device

ActiveCN224462751UPromote activationavoid it happening again
The utility model belongs to vulcanized isobutene production equipment technical field, specifically disclose a high sulfur content vulcanized isobutene production device, including from top to bottom once series' sulfur adding kettle, heat exchanger, vulcanization kettle, sulfur adding kettle top fixedly connected with solid pipe and liquid adding pipe, the first stirrer is rotatably connected in sulfur adding kettle, a plurality of electric heating rods are fixedly connected in sulfur adding kettle, sulfur adding kettle bottom is passed through first connecting pipe and is communicated with heat exchanger, and the heat exchanger is communicated with vulcanization kettle through second connecting pipe, a plurality of air pipes are fixedly connected in vulcanization kettle, a plurality of air nozzles are connected on air pipe, and air pipe is communicated with air inlet pipe that penetrates vulcanization kettle side wall, and the second stirrer is rotatably connected in vulcanization kettle. The utility model sets up sulfur adding kettle, and sets up electric heating rod in sulfur adding kettle, can utilize high temperature and promote the activation of sulfur, avoid the production of mercaptan of elemental sulfur and olefin, thereby reduce the generation of harmful gas.
Owner:GANSU JINBODA NEW MATERIAL TECHNOLOGY CO LTD

A metal-organic framework material for chelating alpha nuclide, its preparation method and application in antitumor drugs

This invention belongs to the field of biomedical technology, specifically relating to a metal-organic framework material for chelating α-nucleotides, its preparation method, and its application in antitumor drugs. The preparation method of the metal-organic framework material involves dissolving ferric chloride tetrahydrate and 2,5-dihydroxy-1,4-benzenediacarboxylic acid in an organic solvent at a molar ratio of 2:3, and reacting at 105°C for 24 hours. The key to this invention is that the metal-organic framework material serves as a novel... 223 The Ra chelation platform can achieve [the desired effect] without relying on traditional chelation mechanisms. 223 The efficient capture and stable loading of Ra effectively solves the chelation problem caused by the intrinsic properties of Ra²⁺ ions, and improves... 223 Ra radiopharmaceuticals offer stability and targeting capabilities, and significantly reduce the risk of radiation exposure to non-target organs.
Owner:SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL +1

Vulcanized nano zero-valent iron composite material as well as preparation method and application thereof

The invention belongs to the technical field of environmental functional materials, and particularly relates to a vulcanized nano zero-valent iron composite material and a preparation method and application thereof. The vulcanized nano zero-valent iron composite material comprises biochar and vulcanized nano zero-valent iron loaded on the biochar. The invention provides a preparation method of a vulcanized nano zero-valent iron composite material, which comprises the following steps: under the protection of an inert atmosphere, dispersing biochar in a ferrite solution to form a mixed solution; dissolving a reducing agent and a vulcanizing agent in an alkaline solution to obtain a mixed reaction solution; and adding the mixed reaction solution into the mixed solution, and carrying out reduction and vulcanization reaction to obtain the vulcanized nano zero-valent iron composite material. According to the invention, a sulfuration modification technology is combined with biochar loading, the biochar effectively prevents agglomeration of nanoparticles and improves the stability and dispersibility of the material, the adsorption effect of the biochar and the catalytic degradation function of sulfurized zero-valent iron generate synergy, and the removal efficiency of the composite material on perfluorinated compounds and other persistent organic pollutants is significantly improved.
Owner:JINGGANGSHAN UNIVERSITY +1

Degradation system promoters for enhanced recycling

PendingCN122295006Apromote degradationPromote activationBiotechnologyWater soluble
This invention provides novel formulations for promoting cell recycling and methods for increasing the responses of various genes related to cell recycling. It also includes degradation system promoters for promoting recycling, containing water-soluble nucleoproteins, particularly low molecular weight compounds (250 to 15000) obtained through enzymatic treatment of fish sclerotium; health foods containing these degradation system promoters; and methods for increasing the responses of various degradation system-related genes and promoting cell recycling through oral intake of these degradation system promoters.
Owner:SHIGERU TOMIJI CO LTD

A TiO2-supported NiCoCuMnAl high-entropy multimetal photothermal methane dry reforming catalyst, its preparation method and application

PendingCN122558496Aeasy to makeConditions are easy to control
This invention discloses a TiO2-supported NiCoCuMnAl high-entropy multimetallic photothermal methane dry reforming catalyst, its preparation method, and its application, belonging to the field of photothermal catalysis technology. The catalyst, designated T-NCCMA, is prepared by: dispersing tetrabutyl titanate in methanol, adding nickel, cobalt, copper, manganese, and aluminum sources to obtain a mixed solution; dissolving 2-methylimidazole in methanol and adding it to the above solution, followed by solvothermal reaction, centrifugation, washing, and drying to obtain a precursor; and finally, high-temperature heat treatment under a reducing atmosphere to obtain the final product. This invention constructs a high-entropy multimetallic interface on the TiO2 surface. Ni / Co sites promote CH4 activation, Mn-regulated defective TiO2 interfaces promote CO2 activation and oxygen transfer, Cu inhibits carbon deposition, and Al improves stability. The resulting catalyst, used in photothermally driven methane dry reforming reactions, exhibits high syngas yield, an H2 / CO ratio close to 1, and excellent anti-carbon deposition stability.
Owner:SUN YAT SEN UNIV