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169results about How to "Promote activation" patented technology

Application of efonidipine in preparation of dendritic cell immunologic adjuvant

The invention relates to the technical field of cellular immunotherapy, in particular to application of efonidipine in preparation of a dendritic cell immunologic adjuvant. The invention provides an application of efonidipine in preparation of a dendritic cell immunologic adjuvant. It is found that efonidipine can promote maturation, migration and antigen presentation functions of DCs, and the homing ability of DCs and CD8 + T cell activation are remarkably improved. The activation aspect of efonidipine on DCs comprises improvement of expression of maturation indexes CD80, CD40 and CD86, expression of a migration index CCR7, activation of CD8 + T cells by antigen presentation and the like. The efonidipine used in the invention is a drug approved by FDA for clinical treatment of cardiovascular diseases, the application of the efonidipine in immunotherapy is found, new use of old drugs is realized, and the efonidipine has great economic value.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES

Preparation method of dispersing agent for ceramics

The invention relates to the technical field of dispersing agents for ceramics, and discloses a preparation method of a dispersing agent for ceramics, and the novel dispersing agent for ceramics is prepared by taking methoxypolyethylene glycol, bromoacetyl bromide, 4-hydroxyphthalic anhydride, 2, 4, 6-diethanolamine amino-1, 3, 5-s-triazine and the like as raw materials. The polyether polyol contains a plurality of carboxyl groups, has strong interaction with the surface of ceramic powder such as aluminum oxide, has a star-shaped multi-arm polyether molecular chain, can well coat the aluminum oxide powder, can effectively inhibit the growth of crystal nucleus particle size of the aluminum oxide powder, reduces the particle size of the aluminum oxide, and avoids agglomeration and sedimentation of the aluminum oxide; the modified aluminum oxide ceramic powder has good activation degree in solvents such as water, ethanol, dichloromethane or N, N-dimethylformamide and the like, is lower in settling volume and shows excellent dispersing performance.
Owner:FOSHAN SANSHUI TAIYANG NEW MATERIAL CO LTD

New application of moss phenol glucoside

The invention belongs to the technical field of medicines, and particularly discloses application of moss phenol glucoside in preparation of medicines for preventing and / or treating tumors. According to the method, activated CD8 + T cells, MC38-OVA cells and traditional Chinese medicine monomeric compounds are co-cultured, the traditional Chinese medicine monomeric compounds capable of effectively promoting the anti-tumor activity of the CD8 + T cells are selected by utilizing a high-content screening technology, and finally, the experiment is carried out by taking the moss phenol glucoside as a research object. In-vitro experiment results show that the moss phenol glucoside can significantly promote T cell activation, promote release of cell factors such as IFN-gamma and TNF-alpha, and enhance the killing effect of T cells on tumors. A mouse in-vivo tumor-bearing experiment result shows that the moss phenol glucoside can promote the anti-tumor activity of T cells so as to inhibit tumor growth, has no obvious toxic or side effect, can be used for preparing the medicine for preventing and / or treating tumors, and has a potential clinical application prospect and a relatively high economic value.
Owner:ZHENGZHOU UNIV

Hydrogen storage nano composite material and powder preparation equipment and preparation method

ActiveCN119568990Ahigh hydrogen storage capacityhigh activityHydrogenMechanical engineeringNanocomposite
The invention relates to the technical field of hydrogen storage, in particular to a hydrogen storage nano composite material, the composition of the hydrogen storage nano composite material is Tix (LaaCebMgc) 2-x (FedCoeMnf) y, x is larger than or equal to 1 and smaller than or equal to 1.5, y is larger than or equal to 1 and smaller than or equal to 1.5, the sum of a + b + c is larger than or equal to 1 and smaller than or equal to 1.2, c is larger than or equal to 0.5, the sum of d + e + f is larger than or equal to 1 and smaller than or equal to 1.05, and f is larger than or equal to 0.5. Comprising an equipment body, supporting carrier plates are symmetrically and fixedly arranged on the two sides of the equipment body, supporting bottom rings are fixedly arranged at the lower ends of the supporting carrier plates, a feeding pipe is fixedly arranged at the upper end of the equipment body, and a discharging bottom opening is formed in the lower side of one end of the equipment body; and a fixed material receiving plate is fixedly arranged in the position, corresponding to the discharging bottom opening, of the interior of the equipment body, a plurality of upper discharging openings are formed in the positions, on the upper side of the discharging bottom opening, of the equipment body, and the invention further relates to a preparation method of the hydrogen storage nano composite material, and the preparation method is used for producing the hydrogen storage nano composite material.
Owner:ZHONGJING (TAIZHOU) HYDROGEN ENERGY TECH CO LTD

Liposome wrapping L-arginine / Prussian blue nanoparticles and preparation method and application thereof

The invention provides lipidosome wrapping L-arginine / Prussian blue nano particles and a preparation method and application thereof, and belongs to the technical field of biological agents. L-arginine is deposited on hPB through iron chelation, then the lipidosome is coated to avoid leakage of water-soluble L-arginine in circulation, and thus the L-arginine / Prussian blue nano particles are obtained. The liposome coated with the L-arginine / Prussian blue nano particles is obtained. Due to the EPR effect, the hPLL-coated Lipo can be efficiently transferred and distributed into tumor tissues, heat is generated under the near-infrared light irradiation condition to ablate a large number of tumor cells, the utilization degree of the tumor cells to L-arginine is greatly limited, meanwhile, immunogenic death is induced, DAMPS is released in situ, infiltration and activation of anti-tumor T cells are further promoted, and the anti-tumor effect is achieved. The tumor immunotherapy is enhanced. And under illumination, the liposome disintegrates and releases the L-arginine, so that nutritional support is provided for immunological competence cells in competitive disadvantage, and activation of an immune microenvironment is promoted.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Unmanned aerial vehicle image transmission signal modulation mode identification system and method based on multi-modal fusion

The invention discloses an unmanned aerial vehicle image transmission signal modulation mode identification system and method based on multi-modal fusion. The method comprises the following steps: (S100) collecting and preprocessing unmanned aerial vehicle communication signal data; (S200) converting the one-dimensional time-domain signal into a two-dimensional Gramer angle field graph and estimating a two-dimensional time-frequency graph of the image transmission signal; (S300) carrying out feature merging; (S400) generating a training set and a test set; (S500) constructing a VGG-ResNet hybrid architecture deep learning network and carrying out training; and (S600) identifying the image transmission signal modulation mode of the unmanned aerial vehicle to be identified. The method disclosed by the invention is based on a multi-modal fusion technology and shows remarkable advantages, and data features of different modals can be comprehensively utilized by fusing the one-dimensional time domain signal and the two-dimensional time frequency graph information to realize more comprehensive description of data.
Owner:XIJING UNIV

Artificial antigen presenting cell for efficiently preparing chimeric antigen receptor T cell as well as construction and application of artificial antigen presenting cell

The invention discloses an artificial antigen presenting cell for efficiently preparing a chimeric antigen receptor T cell (CAR-T) and a construction method of the artificial antigen presenting cell, and belongs to the field of cell therapy and immunotherapy, the artificial antigen presenting cell takes a K562 cell as a platform, an anti-CD3 single-chain antibody, an anti-CD28 single-chain antibody, a membrane binding type cell factor and a costimulatory ligand are stably expressed through genetic engineering, and the chimeric antigen receptor T cell (CAR-T) is obtained. And the local concentration of the anti-CD3 antibody is improved by adopting an HOTag3 tool. The multi-signal integration strategy obviously enhances the activation and proliferation capacity of the T cells, promotes the CAR-T cells to maintain a low differentiation state, and endows the CAR-T cells with excellent anti-tumor activity and durability. The artificial antigen presenting cell provides a novel efficient tool for the field of cellular immunotherapy, and is expected to promote development of more efficient and safer CAR-T therapy to cope with challenges of various malignant tumors.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI +1

Preparation method and application of coal pitch-based porous carbon

The invention belongs to the technical field of material preparation, and particularly relates to a preparation method and application of coal pitch-based porous carbon. The preparation method of the coal pitch-based porous carbon comprises the following steps: (1) in an air atmosphere, performing high-temperature thermal shock treatment on coal pitch for the first time to obtain pre-oxidized pitch; (2) in an inert atmosphere, carrying out second high-temperature thermal shock treatment on the pre-oxidized asphalt to obtain pre-carbonized asphalt; and (3) mixing the pre-carbonized pitch with an activating agent to obtain mixed powder, and performing third high-temperature thermal shock treatment on the mixed powder to obtain the coal pitch-based porous carbon. The preparation method has the beneficial effects that the coal pitch is subjected to pre-oxidation treatment by utilizing high-temperature thermal shock, so that the specific surface area of the coal pitch porous carbon is increased; the pre-oxidized pitch is subjected to pre-carbonization treatment by adopting high-temperature thermal shock, so that the carbon yield and stability of a final product are improved, and the coal pitch-based porous carbon has an ideal porous structure and a relatively high specific surface area.
Owner:CCTEG CHINA COAL RES INST

Tumor microenvironment response fusion protein-metal ion compound prodrug system as well as preparation method and application thereof

The invention provides a novel platform for tumor immunotherapy. The platform is formed by self-assembly of full-heavy-chain human ferritin which can be jointly fused and expressed by a polypeptide prodrug mask which can be activated by protease and a mitochondrial disrupting peptide, and can specifically target a tumor microenvironment and induce ICD death of tumors. Meanwhile, an ion channel is formed in a protein shell of the platform, so that immunocompetence metal ions can be loaded in a cavity of the platform, and time-space synchronous anti-tumor immune activation can be carried out in cooperation with ICD. As the mitochondrial disrupting peptide and the metal ions can be optimized according to tumor types, the platform can be used for treating various tumors.
Owner:CHINA PHARM UNIV

Electrochemical-catalyst dual-activated reactor for efficiently degrading azo dye by persulfate

The invention discloses an electrochemical-catalyst dual-activated reactor for efficiently degrading azo dye by persulfate, which comprises: a reactor main body comprising a pretreatment chamber, a main reaction chamber and a post-treatment chamber which are mounted from bottom to top; the electrochemical unit comprises an anode, a cathode and a direct-current stabilized power supply, and the two ends of the direct-current stabilized power supply are electrochemically connected with the anode and the cathode; the catalyst unit is mounted at the bottom of the main reaction chamber; the liquid conveying system is used for sequentially conveying wastewater and a persulfate solution to the pretreatment chamber, the main reaction chamber and the post-treatment chamber, and the wastewater and the persulfate solution circularly flow in the chambers to finish pretreatment, degradation treatment and post-treatment; and the gas spraying system is used for uniformly inputting gas into the main reaction chamber. The reactor combines a dual activation mechanism of electrochemistry and a catalyst, generates active species with strong oxidizing property, remarkably improves the degradation effect of azo dyes, and has the advantages of high efficiency, simplicity and convenience in operation, wide applicability and the like.
Owner:CHINA UNIV OF MINING & TECH

Wafer refrigerating system of ion implanter

The invention discloses a wafer refrigerating system of an ion implanter, which is characterized in that a cold ring and a process target disc for bearing a first wafer are arranged in a process chamber, the process target disc is arranged at the top of the cold ring, and the bottom of the cold ring is connected with a distributor through a refrigerant penetrating pipe; a pre-cooling ring and a pre-cooling target disc used for bearing a second wafer are arranged in a mechanical arm cavity, the pre-cooling ring is arranged at the bottom of the pre-cooling target disc, the bottom of the pre-cooling ring is connected with a distributor through a pipeline, the distributor is connected with a cold source through a pipeline, and low-temperature nitrogen provided by the cold source is conveyed into the distributor to be distributed for the second time. Then the wafers are conveyed to a cooling ring and a pre-cooling ring respectively, so that the first wafer on the process target disc and the second wafer on the pre-cooling target disc are cooled to a preset temperature; and the low-temperature nitrogen is subjected to heat exchange in the cold ring and the pre-cooling ring, then returns to the distributor and finally returns to the cold source for cyclic utilization. The low-temperature injection device has the characteristics of compact structure, convenience in operation, high refrigeration efficiency and the like, and the overall working efficiency of low-temperature injection is improved.
Owner:BEIJING SHUOKE ZHONGKEXIN ELECTRONICS EQUIP CO LTD

Calcium carbonate modified polypropylene composite material and preparation method thereof

ActiveCN119591975Aconcentrated size distributionUniform particle sizePolyolefinHigh activation
The invention provides a calcium carbonate modified polypropylene composite material and a preparation method thereof.The preparation method comprises the steps that calcium carbonate powder and a surfactant containing double bonds are mixed and stirred at the high temperature for preset time, and surface modified calcium carbonate is obtained; and mixing the surface modified calcium carbonate with polypropylene and an initiator, stirring for a preset time, and carrying out melt extrusion at 170-210 DEG C to obtain the calcium carbonate modified polypropylene composite material. The preparation method provided by the invention has the advantages of rapid activation and simple process, and the prepared surface modified calcium carbonate powder has the advantages of concentrated size distribution, uniform particle size and high activation degree, has good compatibility with polyolefin materials, can enhance the tensile strength and other mechanical properties of a composite material when being filled into a polymer, and has good application prospects. And good economic benefits are achieved.
Owner:HUBEI WEIPU INORGANIC NON-METAL NEW MATERIALS CO LTD

Silicon-carbon negative electrode material, preparation method thereof, negative electrode slurry, negative electrode plate and application

The invention provides a silicon-carbon negative electrode material, a preparation method thereof, negative electrode slurry, a negative electrode plate and application. The invention provides a preparation method of a silicon-carbon negative electrode material, which comprises the following steps: S1, mixing linear phenolic resin with an organic solvent, sequentially adding urotropine, carbon nanotubes, a defoaming agent and polycarbosilane, and mixing to form a mixture; s2, drying, cross-linking, carbonizing, activating and cooling the mixture to obtain a porous carbon material; s3, silane mixed gas is introduced into the porous carbon material, silane deposited porous carbon is obtained through deposition, then acetylene mixed gas is introduced, nitrogen is introduced after acetylene deposition, and the silicon-carbon negative electrode material is obtained through cooling; wherein the polycarbosilane is a compound as shown in a formula I, and n ranges from 1000 to 2000. According to the negative electrode material prepared by the method, the mesoporous strength is improved, the expansion coefficient is reduced, the cycle retention rate of the battery is improved, and the service life of the battery is prolonged. # imgabs0 #
Owner:NINGBO SHANSHAN SILICON-BASED MATERIALS CO LTD

Ti-Fe-Y-Mn-Zr-Co-Zn based hydrogen storage alloy easy to activate and preparation method thereof

The invention relates to an easily-activated Ti-Fe-Y-Mn-Zr-Co-Zn-based hydrogen storage alloy and a preparation method thereof, belongs to the technical field of hydrogen storage alloy materials, and solves at least one of the problems of high activation difficulty, long activation period, poor hydrogen absorption and desorption dynamic performance and the like of a Ti-Fe-based hydrogen storage alloy in the prior art. The invention provides a Ti-Fe-Y-Mn-Zr-Co-Zn based hydrogen storage alloy easy to activate, the chemical formula of the hydrogen storage alloy is Ti 1.15, Fe 0.8, Y 0.03, Mn 0.35-x-y-z ZrxCoyZnz, x, y and z are atomic ratios, x is larger than or equal to 0.05 and smaller than or equal to 0.15, y is larger than or equal to 0.02 and smaller than or equal to 0.1, and z is larger than or equal to 0.02 and smaller than or equal to 0.1. The Ti-Fe-Y-Mn-Zr-Co-Zn based hydrogen storage alloy provided by the invention obtains good activation performance and hydrogen absorption and desorption performance by means of component design and preparation process improvement, can be activated at one time under the conditions of 30 DEG C and 3 MPa, and has the hydrogen storage capacity of more than or equal to 1.69 wt.%, the hydrogen absorption platform pressure of more than or equal to 0.39 MPa and the hydrogen desorption platform pressure of more than or equal to 0.3 MPa.
Owner:CHINA IRON & STEEL RESEARCH INSTITUTE GROUP CO LTD

Polymer-coated modified heavy calcium carbonate composite particle as well as preparation method and application thereof

The invention belongs to the technical field of inorganic powder, and discloses polymer-coated modified heavy calcium carbonate composite particles as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing and stirring heavy calcium carbonate and a mixed solution of NaOH and Na2CO3, and carrying out suction filtration, washing and drying; adding KH-570 hydrolysate into the obtained surface hydroxylated ground calcium carbonate, continuously stirring in an oil bath pan, carrying out reflux condensation reaction for 3 hours, carrying out suction filtration, and drying to obtain KH570-OH-GCC; sequentially adding lauryl sodium sulfate, deionized water and KH570-OH-GCC, and adding an initiator for reaction; dropwise adding a mixed solution of butyl acrylate and ethylene glycol dimethacrylate, and reacting for 2 hours after dropwise adding; and adding an emulsifier, continuously stirring, dropwise adding a mixed solution of methyl methacrylate and allyl methacrylate, reacting for 2.5 hours after dropwise adding, cooling, carrying out suction filtration, and drying to obtain the polymer-coated modified heavy calcium carbonate composite particles.
Owner:GUANGDONG UNIV OF TECH +1

Personalized tumor vaccine based on hydrogel as well as preparation method and application thereof

The invention belongs to the technical field of tumor vaccines, and discloses a personalized tumor vaccine based on hydrogel and a preparation method and application thereof, the preparation method comprises the following steps: adding a chemotherapeutic drug into a mixed solution of polyphenol and metal ions, uniformly mixing, adjusting the pH value of the solution, and reacting for 2-8 hours to obtain a metal polyphenol nano-carrier loaded with the chemotherapeutic drug; co-culturing the obtained metal polyphenol nano-carrier loaded with the chemotherapeutic drug and tumor cells for 12-48 hours, and inducing the tumor cells to generate immunogenic cell death, wherein the concentration of the metal polyphenol nano-carrier loaded with the chemotherapeutic drug is 1-20 [mu] g / mL; the tumor cell suspension in the ICD state and the STING agonist solution are mixed with the sodium alginate solution, and the personalized tumor vaccine is obtained. The ICD is induced in vitro by the chemotherapeutic drug, so that the toxic and side effects of systemic administration are reduced, the types of antigens are enriched, and a powerful guarantee is provided for the vaccine to activate a strong in-vivo anti-tumor immune response.
Owner:SHANDONG UNIV

Flotation preactivator for antimony oxide ore and activation and flotation method thereof

The present invention belongs to the field of mineral flotation, and specifically relates to a flotation preactivator for antimony oxide ore, comprising an electrolyte, a tartaric acid source and a sulfiding agent; the electrolyte is a water-soluble inorganic salt; the tartaric acid source is tartaric acid and its water-soluble salt; the sulfiding agent is a water-soluble organic sulfide containing at least one group of HS-, -S-. The present invention also includes a method for activating antimony oxide ore and flotation using the activator. In the present invention, the activator can effectively improve the flotation performance of the antimony oxide ore.
Owner:CENT SOUTH UNIV

Preparation method and application of Ni-CeO2 catalyst

The invention relates to a preparation method and application of a Ni-CeO2 catalyst. The method comprises the following steps: (1) dissolving nickel precursor salt, cerium oxide precursor salt and citric acid monohydrate in deionized water to prepare a mixed solution; (2) refluxing, stirring and aging the mixed solution in a water bath at 50-90 DEG C for 1-5 hours; (3) performing rotary evaporation on the aged sol to obtain gel; after drying, grinding into powder, and calcining at 300-500 DEG C to obtain a NiO-CeO2 precursor; (4) reducing the obtained NiO-CeO2 precursor, so as to obtain a Ni-CeO2 catalyst A; the prepared Ni-CeO2 catalyst is used for methanation reaction. The catalyst has excellent carbon dioxide conversion rate and methane selectivity at low temperature, and meanwhile, the catalyst has long-period stability and good carbon deposition resistance.
Owner:HEBEI UNIV OF TECH

Method for improving nutritional quality of germinated brown rice through ultrasonic-assisted salt induction

The invention aims to provide a method for improving nutritional quality of germinated brown rice through ultrasonic-assisted salt induction. Brown rice is a whole-grain product and is rich in nutritional ingredients such as starch, protein, dietary fibers, vitamins and mineral substances and active functional factors. The nutritional ingredients of the germinated brown rice change drastically, and the nutritional value of the brown rice is greatly improved. According to the method, brown rice is taken as a raw material, the brown rice is soaked in a CaCl2 salt solution under the assistance of ultrasound, the germination temperature and time are optimized, the concentration of the CaCl2 salt solution is taken as an influence factor, and the change rule of nutritional ingredients and functional factors of the brown rice in the germination process is researched. Results show that after ultrasonic-assisted salt induction treatment, the contents of vitamin B2 and vitamin B6 in the germinated brown rice are increased to 58.2 mu g / 100g and 0.438 mg / 100g, and the content of gamma-aminobutyric acid is increased to 42.6 mg / 100g (dry basis). The germination of the brown rice promotes the activation and release of hydrolases such as amylase, protease and phytase, and nutritional ingredients in the brown rice are migrated, degraded, accumulated and the like, so that the nutritional quality of the brown rice is remarkably improved.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Tobacco extract for promoting wound healing and preparation method and application thereof

The invention discloses a tobacco extract for promoting wound healing, the tobacco extract comprises a tobacco acid water layer extract and a tobacco alcohol layer extract, the tobacco acid water layer extract and the tobacco alcohol layer extract are both mixtures of nicotine, chlorogenic acid and solanesol, and a preparation method of the tobacco extract comprises the steps of tobacco extraction, extraction treatment, purification pretreatment and purification treatment. The invention also discloses an application of the tobacco extract in promoting wound healing. The traditional Chinese medicine has the advantages of being convenient to use and small in side effect, wound healing can be promoted, meanwhile, the effects of local bacteriostasis, anti-inflammation, angiogenesis promotion and the like are achieved, complications such as wound infection are avoided, and the traditional Chinese medicine comprehensively plays a role in different stages of wound healing.
Owner:CHINA NATIONAL TOBACCO CORPORATION HUNAN PROVINCIAL CORPORATION

A herbal hair loss prevention, hair growth and hair darkening composition and preparation method thereof

ActiveCN118717632BImprove anti-offGood hair effectCosmetic preparationsHair cosmetics
The present invention relates to the technical field of cosmetics, and in particular to a herbal hair loss prevention, hair growth, and hair darkening composition and a preparation method thereof. The present invention adopts Polygonum multiflorum, Elm bark, ginger, alfalfa, Gallnut, Lycium bark, and Hamamelis virginiana, which have hair loss prevention, hair growth, and hair darkening effects, to prepare a hair composition. The present invention optimizes the ratio of raw materials, enhances the matching effect of active ingredients, and makes the hair loss prevention, hair growth, and hair darkening effects of the composition better. At the same time, the present invention adopts hot water extraction and dissolution, composite bacteria combined fermentation, and ethanol aqueous solution extraction processes to increase the types of active ingredients and the concentration of active substances, enhance the efficacy of the medicine, and can further improve the hair loss prevention, hair growth, and hair darkening effects of the composition.
Owner:INNER MONGOLIA MENGYUANTANG BIOTECHNOLOGY CO LTD

Ultra-light foaming material with micropore channels and preparation method of ultra-light foaming material

The invention relates to the technical field of thermoplastic material foaming, in particular to a preparation method of an ultralight foaming material with micropore channels. The invention relates to an ultralight foaming material with micropore channels. The ultralight foaming material comprises the following substances in parts by weight: 80-90 parts of thermoplastic matrix resin; 0.1 to 2 parts of a pore-foaming agent; 0.1 to 0.8 part of a functional auxiliary agent; 10 to 20 parts of auxiliary materials; the pore-foaming agent comprises one or a mixture of more of activated carbon, zeolite, porous ceramic and hollow glass microspheres. According to the technical scheme, the thermoplastic matrix resin is selected to be combined with the pore-forming agent, the composite material formed after foaming treatment has a good vacuum channel structure, the density of the material is effectively reduced, the porosity of the material is improved, on the basis, selection of the pore-forming agent is optimized, and the porosity of the material is improved. The prepared ultralight foaming material has different pore structures and adsorption performance, and more excellent material performance can be obtained through mixed use.
Owner:CHANGZHOU SHUNXIANG NEW MATERIAL TECH CO LTD

Application of asparaginase in preparation of medicine for treating pancreatic cancer

PendingCN119524113Apromote apoptosisReduce activationOrganic active ingredientsPeptide/protein ingredientsGemcitabine resistancePancreas Cancers
The invention belongs to the technical field of biological medicines, and particularly relates to application of asparaginase in preparation of a medicine for treating pancreatic cancer. The asparaginase and the gemcitabine are combined for treating pancreatic cancer, and results show that the combination of the two medicines can promote apoptosis of pancreatic cancer cells, reduce proliferation and reduce activation of pancreatic stellate cells, so that an important scientific basis is provided for improving gemcitabine drug resistance, and meanwhile, a new application is provided for the asparaginase.
Owner:SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV

Hindered Lewis acid-base pair type oxygen-enriched defect hydroxyl vanadium oxide Fenton-like catalyst as well as preparation method and application thereof

The invention discloses a hindered Lewis acid-base pair type oxygen-enriched defect hydroxyl vanadium oxide Fenton-like catalyst as well as a preparation method and application thereof, and belongs to the technical field of water treatment. The preparation method comprises the following steps: adding vanadate into deionized water, and ultrasonically stirring to obtain a vanadate solution; adding a peroxydisulfate solution into the vanadate solution drop by drop, uniformly stirring, and then adding ammonia water; carrying out hydrothermal reaction on the suspension to obtain precursor powder; and spreading the precursor powder on conductive glass, placing the conductive glass in a plasma discharge device, vacuumizing, introducing gas, and then starting up for discharge treatment to obtain the vanadium oxyhydroxide. According to the invention, oxygen vacancies are produced on the material through a discharge treatment process, so that a local coordination environment of adjacent spaces of V and-OH is changed, unbonded Lewis acid and Lewis base with close steric hindrance form a hindered Lewis acid-base pair, and the hindered Lewis acid-base pair as a Fenton-like catalyst can enhance and activate peroxide to generate a large number of active oxide species to degrade antibiotic pollutants.
Owner:HEFEI INSTITUTE OF PHYSICAL SCIENCE CHINESE ACADEMY OF SCIENCES

Method for two-stage preparation of nano-biochar from waste straws and application of nano-biochar

The invention discloses a method for two-stage preparation of nano biochar from waste straws and application of the nano biochar. The method comprises the following steps: naturally air-drying the waste straws for 72-96 hours, drying at 60-80 DEG C for 24-48 hours, crushing, sieving with a 60-mesh sieve, and sealing for later use; the method comprises the following steps: carrying out hydrothermal reaction on waste straws at 180-240 DEG C for 1-2 hours to obtain hydrothermal carbon, and carrying out pyrolysis on the hydrothermal carbon at 300-900 DEG C under the protection of inert gas for 1-3 hours to obtain biochar; the preparation method comprises the following steps: putting biochar into a ball milling tank, adding agate balls with a mixed size, then adding deionized water to wet a sample, putting the sample into a planetary ball mill, and carrying out wet grinding to obtain the nano biochar. The prepared nano biochar has a smaller hydrodynamic radius, a larger specific surface area and a rich pore structure, active sites on the surface of the nano biochar are increased, activation of PMS can be promoted, more ROS with high reactivity can be generated, and the nano biochar has higher catalytic degradation potential.
Owner:HENAN NORMAL UNIV

Method for connecting metal-based shape memory alloy plate and structure to be reinforced

The invention discloses a connecting method for a metal-based shape memory alloy plate and a to-be-reinforced structure. The metal-based shape memory alloy plate is fixed to the to-be-reinforced structure through an anchoring device. Comprising a first working condition, a second working condition, a third working condition and a fourth working condition, the iron-based shape memory alloy plate is fixed to a to-be-reinforced structure through the anchoring device, and the purpose of connecting the iron-based shape memory alloy plate and the to-be-reinforced structure is achieved. The anchoring device is used for installing an iron-based shape memory alloy plate to the bottom of a structure to be reinforced and mainly comprises a base plate, a bottom plate, a cover plate, a clamping piece and a high-strength bolt. According to the method, four working conditions correspond to different bearing capacities; the method does not need glue coating, instability is reduced, and the connecting device can be repeatedly used; grouting or wet operation is not needed, the reinforcing construction period is greatly shortened, the iron-based shape memory alloy plate is arranged outside the to-be-reinforced structure, and actual construction and maintenance and activation of the iron-based shape memory alloy plate are facilitated.
Owner:TONGJI UNIV

Method for repairing polycyclic aromatic hydrocarbon contaminated soil

The invention relates to a method for repairing polycyclic aromatic hydrocarbon contaminated soil, which comprises the following specific steps: S1, eluting the polycyclic aromatic hydrocarbon contaminated soil by using a surfactant to obtain eluted soil; s2, modifying the biochar by adopting a modification solution to obtain modified biochar; and S3, the modified charcoal obtained in the step S2, MoS2 and monopersulfate are mixed and put into the eluted soil obtained in the step S1, and remediation of the polycyclic aromatic hydrocarbon contaminated soil is completed. Compared with the prior art, when the surface active agent, the biochar and the MoS2 technology are comprehensively applied to remediation of the polycyclic aromatic hydrocarbon contaminated soil, the surface active agent is firstly used for enhancing the solubility and the bioavailability of the PAHs; then, the modified biochar is combined with a MoS2 or PMS system to form a composite remediation system, and the removal efficiency and the remediation effect of polycyclic aromatic hydrocarbons (PAHs) can be improved.
Owner:SHANGHAI INST OF TECH

Battery pole piece and preparation method thereof, lithium ion battery and electric vehicle

PendingCN121862682ARealize the heating functionWill not affect charging and discharging efficiencyElectrode manufacturing processesSecondary cellsElectrical batteryManganese
The invention relates to the technical field of batteries, in particular to a battery pole piece, a preparation method of the battery pole piece, a lithium ion battery and an electric vehicle. The battery pole piece comprises a foil and an electrode material layer which are arranged in sequence, the material of the electrode material layer comprises manganese-cobalt-nickel oxide, the chemical general formula of the manganese-cobalt-nickel oxide is MnxCoyNizO, x is equal to 0.2-0.4, y is equal to 0.2-0.4, z is equal to 0.4-0.6, and x + y + z is equal to 1. The invention aims to improve the low-temperature performance of the battery without influencing the performance of the battery in a high-temperature environment.
Owner:ZHEJIANG GEELY HLDG GRP CO LTD +2

Method for preparing nanographene by high-temperature flash pyrolysis of PET waste plastic powder

The invention discloses a method for preparing nano-graphene by high-temperature flash pyrolysis of PET waste plastic powder, comprising: tearing and crushing, washing and impurity removal, deep cold crushing, warehouse pump gas delivery, flash carbonization, chemical activation, pyrolysis activation, neutralization washing, air flow drying, and product collection. The invention proposes a method for preparing nano-graphene by high-temperature flash pyrolysis of PET waste plastic powder in an oxygen-free environment using recycled waste PET plastic as a precursor carbon source and solid waste treatment. The method has the advantages of abundant raw material sources, easy solid waste recycling, high plastic carbon content, simple preparation process, green, low-carbon and environmentally friendly, low production cost, high product added value and high comprehensive utilization efficiency, and suitability for industrial-scale production.
Owner:GUANGXI XINGANG FUTURE NEW MATERIALS CO LTD