The invention relates to the field of communication, and specifically relates to a user clustering and resource distribution method in a D2D multicast scene. The method comprises the steps that S1, each mobile terminal uploads data information to a base station after measurement; S2, the base station selects a proper cluster head for a content requesting user according to the data information uploaded by each mobile terminal, and forms an optimal D2D multicast cluster; S3, the base station transmits the clustering information to the content requesting user; S4, resources are distributed to the formed D2D multicast cluster, and a cellular user who meets the requirements of a cellular user and D2D multicast cluster QoS at the same time and generates the minimum interference with the D2D multicast cluster; S5, each mobile terminal carries out the data transmission after receiving the clustering and resource distribution information. The method can improve the service experience of an edge user, reduces the load of the base station, improves the transmission efficiency, reduces the interference, caused by the multiplexing of the frequency spectrum resources of the cellular user, with the D2D multicast cluster, and improves the utilization rate of resources.