8 results about "HEMOSTATIC POWDER" patented technology

The application discloses a kind of multilayer nanostructure hemostatic powder and preparation method thereof, belong to the field of biomedical hemostatic material.To solve the problem of insufficient mechanical strength of existing silk fibroin-polyphenol hemostatic material, the silk fibroin solution is mixed with regenerated chitin nanofiber solution in proportion, and tea polyphenol solution is added dropwise to induce co-assembly and gelation, and the powder is prepared by washing, freeze-drying and grinding.The powder can quickly absorb water and self-gel after contacting with blood, and form a stable three-dimensional network hydrogel within a few seconds.The regenerated chitin nanofiber guides the formation of hierarchical nanostructure of silk fibroin through supramolecular interaction, significantly enhances the mechanical strength and adhesion, while tea polyphenol provides antibacterial, antioxidant and procoagulant functions.The hemostatic powder of the application has the functions of rapid hemostasis, strong adhesion in wet state, resistance to flushing and promotion of wound healing, and is suitable for various acute bleeding scenarios.

The invention discloses ionic cross-linked starch hemostatic powder and a preparation method and application thereof.The preparation method includes the steps that carboxymethyl starch with the substitution degree not smaller than 0.3 is dissolved in deionized water to be continuously stirred, a metal ion solution is quantitatively and dropwise added into the solution to obtain floccules, the floccules are centrifuged, washed and freeze-dried, and the ionic cross-linked starch hemostatic powder is obtained; the ionic cross-linked starch hemostatic powder is prepared. The preparation process is mild in reaction condition, a chemical cross-linking agent with poor biological safety is not needed, the process is simple and environment-friendly, and large-scale production is easy to realize.

The utility model discloses a kind of self-adhesive wound protective stickers, including supporting base layer, release paper and adhesive layer, the center of supporting base layer bottom is provided with cavity, the edge position of inside of cavity is provided with antibacterial layer, antibacterial layer below is provided with hemostatic absorbent cotton layer, the inside of hemostatic absorbent cotton layer is uniformly provided with analgesic powder and hemostatic powder, and the inside of antibacterial layer above hemostatic absorbent cotton layer is provided with drug sustained-release layer, the inside of drug sustained-release layer is uniformly provided with biodegradable material bag, the inside of each biodegradable material bag is filled with healing drug.The breathable film layer of the utility model is arranged on the top of antibacterial layer, below the secondary waterproof film layer, this design not only ensures waterproof effect, but also can tear the secondary waterproof film layer when necessary, allow the gas exchange of skin at wound, avoid the skin stuffy, uncomfortable and other problems caused by poor breathability, improve the use experience of patient.

This invention discloses a gelatin-based hemostatic powder with high osmotic pressure properties and its preparation method. The hemostatic powder is a porous gelatin-based material grafted with high-osmotic-pressure anionic functional groups such as sulfonic acid groups or their derivatives. The sulfonic acid groups or their derivatives endow the hemostatic powder with negative charge and high osmotic pressure properties, thereby achieving a dual hemostatic effect of osmotic pressure-driven blood concentration and negative charge enrichment to activate coagulation factors. The strong dissociation properties of the sulfonic acid groups or their derivatives endow the material with a surface negative potential of -20 to -50 mV and a high osmotic pressure of 0.30 to 0.55 Osmol / kg, achieving a pressure of 40 to 60 g·g. ‑ ¹ water absorption ratio and 0.15–0.20 g·g ‑ ¹·min ‑ ¹ Rapid water absorption. The preparation method of this invention involves activating the carboxyl group of gelatin and grafting a functional monomer containing a primary amino group, followed by purification, freeze-drying, and grinding. This invention achieves dual hemostatic effects of osmotic pressure-driven blood concentration and negatively charged enrichment to activate coagulation factors, making it suitable for wound hemostasis of arterial, venous, and organ bleeding.

A flexible hemostatic pad formed from a hemostatic powder, which may contain a hydrophilic polymer such as a cation ion exchange resin, compressed onto or into a velvet-like backing substrate is provided for the control of bleeding at a wound site.

This invention belongs to the field of hemostatic wound dressing technology, specifically relating to a portable hemostatic powder that can quickly stop bleeding, its preparation method, and its application. The hemostatic powder is prepared by physically mixing carboxymethyl chitosan, hydroxypropyl methylcellulose, and tannic acid. The amino groups in carboxymethyl chitosan electrostatically attract blood cells, promoting blood cell aggregation and thus accelerating coagulation. Hydroxypropyl methylcellulose has excellent hygroscopic properties, providing the powder with rapid blood absorption. Tannic acid, through its catechol groups, captures free radicals, possesses anti-inflammatory effects, and exhibits excellent wet tissue adhesion, synergistically stopping bleeding with carboxymethyl chitosan. The prepared hemostatic powder has the advantages of low cost, convenient preparation, portability, and rapid hemostasis.

The application relates to the technical field of medical materials, in particular to a high-molecular adhesive material and a preparation method and application thereof. The preparation method of the high-molecular adhesive material comprises the following steps: adding alkali into acrylic acid to obtain neutralized acrylic acid; adding the neutralized acrylic acid, sodium carboxymethyl cellulose and N-hydroxysuccinimide acrylate into an inorganic solvent, then adding potassium persulfate (KPS), and heating to react to obtain a gel; and freeze-drying the gel to obtain the high-molecular adhesive material, namely, a CMC / PAA-NHS adhesive modified by N-hydroxysuccinimide. The application also provides the high-molecular adhesive material prepared by the preparation method and application of the high-molecular adhesive material as a medical material. The application solves the problem of poor adhesion of existing hemostatic sponges and hemostatic powders, and also solves the problem of limited hemostatic performance of hydrogel adhesives.