60 results about "HEMOSTATIC POWDER" patented technology

The invention discloses a hemostasis device and a hemostasis method for an anorectal lacuna operation, and belongs to the technical field of medical instruments. The hemostasis device for the anorectal lacuna operation comprises a fixed tube, a movable tube is arranged in the fixed tube, the movable tube is connected with the fixed tube in a rotating and sliding mode, an expansion structure used for expanding anorectum is arranged on the upper portion of the movable tube, and an expander driving the expansion structure to expand or contract is arranged in the movable tube. The anorectum is expanded through the expansion structure, and hemostasis operation can be conveniently conducted on the anorectum; the inner tube and the outer tube are rotationally and slidably connected, so that the adaptability of the hemostasis device is improved; the hemostatic effect is improved through the hemostatic powder and the compression air bag. Therefore, by adopting the hemostasis device and the hemostasis method for the anorectal lacuna operation, the problems that an existing device is poor in adaptability and cannot effectively stop bleeding can be solved.

Aiming at the inadequacy of existing hemostatic materials for large-scale trauma and serious bleeding, the present invention provides a silk fibroin complex loaded with a polyhydroxy phenolic compound and a preparation method therefor. The complex is prepared by self-assembly of the polyhydroxy phenolic compound and the silk fibroin. The silk fibroin is subjected to a β-sheet conformation transformation process. The polyhydroxy phenolic compound is preferably an indissoluble compound, most preferably ellagic acid. The feeding ratio of the polyhydroxy phenolic compound to the silk fibroin is a mass ratio of ˂ 1:1, preferably 1:2 to 1:16, more preferably 1:4. The hemostatic ability of the complex is significantly superior to that of the polyhydroxy phenolic compound, the silk fibroin, Yunnan Baiyao, tranexamic acid, chitosan hemostatic powder, and the like. Meanwhile, the complex has a larger particle size and mass than the silk fibroin, and can rapidly settle to a bleeding site in blood. The complex exhibits no cytotoxicity, is blood-insoluble, and is capable of self-degradation in vivo, demonstrating high safety. Meanwhile, the complex has the characteristics of wound healing, antibiosis, infection resistance, adhesion resistance, and the like, and can be applied to the preparation of corresponding formulations.

The invention provides a silk fibroin hemostatic sponge loaded with polyhydroxy phenolic compounds and a preparation method of the silk fibroin hemostatic sponge, aiming at the defect that hemostatic materials have poor effects on large wounds and serious bleeding, and the silk fibroin hemostatic sponge loaded with the polyhydroxy phenolic compounds is prepared from silk fibroin compounds loaded with the polyhydroxy phenolic compounds, wherein the silk fibroin compound loaded with the polyhydroxy phenolic compound is prepared from the polyhydroxy phenolic compound and silk fibroin according to the feeding mass ratio of 1t; the material is prepared in a 1: 1 self-assembly mode. The polyhydroxy phenolic compound is preferably insoluble and most preferably ellagic acid, and the feeding ratio of the polyhydroxy phenolic compound to the silk fibroin is preferably 1: 2-1: 16 and more preferably 1: 4. The hemostatic capacity of the silk fibroin compound loaded with the polyhydroxy phenolic compound is remarkably superior to that of silk fibroin, Yunnan Baiyao, tranexamic acid, chitosan hemostatic powder and the like, and the silk fibroin compound is free of cytotoxicity, free of hemolysis, capable of being self-degraded and high in safety. The silk fibroin hemostatic sponge loaded with the polyhydroxy phenolic compound has excellent hemostatic performance, is easy to peel, does not cause secondary damage, and can be self-degraded.

The invention relates to absorbable adhesive styptic powder and a preparation method thereof, and the absorbable adhesive styptic powder is characterized in that the absorbable adhesive styptic powder is formed by cross-linking aldehyde polysaccharide and a polyamino compound through Schiff base reaction, the raw materials are selected from at least one of glucan, sodium carboxymethyl cellulose, sodium hyaluronate, chitosan and carboxymethyl starch; the polyamino compound is selected from at least one of polylysine, polypeptide, bovine serum albumin and polyamine; the styptic powder is porous particles with the particle size of 10-1000 meshes, is cured into gel within 10 seconds after being in contact with body fluid, and is completely degraded within 15-60 days. According to the scheme, the styptic powder has the advantages of rapid wet adhesion, controllable degradation and excellent processability, and is an urgent clinical demand.

The invention discloses a preparation method and application of collagen derivative and polysaccharide substance compounded self-gel hemostatic powder, and relates to the field of biomedical materials. Aminated collagen derivatives and aldehyde polysaccharide substances are subjected to a Schiff base reaction through amino groups and aldehyde groups; further obtaining the Schiff base cross-linked aminated collagen derivative-aldehyde polysaccharide hydrogel, freeze-drying, and grinding into powder, so as to obtain the self-gel hemostatic powder. The self-gel hemostatic powder disclosed by the invention forms hydrogel in a wound tissue for adhesion and sealing, so that rapid hemostasis is realized, postoperative adhesion at the wound tissue is avoided, and healing of a wound is facilitated; after hemostasis is completed, the self-gel powder can be dissociated and removed from the tissue surface, and the risk that thrombus is formed and immunological rejection is caused is reduced; after hemostasis is completed, the hemostasis powder can be metabolized and absorbed by a human body along with thrombus, so that the residue of the hemostasis powder in the body is reduced, and the safety is improved.

The application discloses a medical hemostatic powder spraying device and relates to the technical field of medical hemostatic powder, which is characterized in that the device comprises a quantitative powder discharging assembly arranged in the interior of a shell and used for quantitatively discharging powder, a quantitative gas feeding assembly arranged in the interior of the shell and used for quantitatively feeding gas, and a linkage assembly arranged between the quantitative powder discharging assembly and the quantitative gas feeding assembly and used for controlling the quantitative powder discharging assembly and the quantitative gas feeding assembly to work cooperatively. The quantitative powder discharging assembly can quantitatively discharge the hemostatic powder, so that the powder discharging amount can be accurately controlled. The quantitative gas feeding assembly can quantitatively feed gas, so that the gas discharging amount is controlled, and the airflow for spraying the powder is more uniform. The quantitative powder discharging assembly and the quantitative gas feeding assembly work cooperatively, so that the accurate powder discharging amount is uniformly blown out, and the spreading of the hemostatic powder is more uniform and efficient.

To provide apparatuses and methods for the endoscopic delivery of hemostatic powders.SOLUTION: In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.SELECTED DRAWING: None

A device for delivering an agent includes a valve assembly including a cavity for storing the agent and an agitation mechanism movably disposed inside the cavity. An inlet conduit fluidly coupled to a fluid source and the valve assembly. An outlet conduit fluidly coupled to the valve assembly, wherein the inlet and outlet conduit are each in fluid communication with the cavity. The agitation mechanism is configured to agitate the agent within the cavity in response to the agitation mechanism moving inside the cavity. The valve assembly is configured to urge the agitation mechanism to move inside the cavity in response to receiving a fluid from the fluid source via the inlet conduit, combine the fluid with the agent within the cavity in response to the agitation mechanism moving inside the cavity, and deliver a combination of the agent and the fluid out of the cavity through the outlet conduit.

The invention relates to the technical field of hemostatic materials, in particular to antibacterial and anti-inflammatory silicon carbide ore-based multifunctional hemostatic powder and a preparation method thereof. The preparation method of the silicon carbon ore-based multifunctional styptic powder comprises the following steps: S1, dispersing epsilon-polylysine and silicon carbon ore in water, then freeze-drying and grinding into powder; s2, the epsilon-polylysine modified silicon carbon ore is dispersed in water, and a Pl-EPL solution is prepared; s3, adding the Pl-EPL solution and the berberine solution into the polyacrylic acid solution, and uniformly mixing; and then, under a stirring condition, dropwise adding a polyethyleneimine solution into the mixed solution, freeze-drying, and grinding into powder. The hemostatic material disclosed by the invention can participate in the blood coagulation process more efficiently, exert antibacterial and antioxidant effects, reduce inflammatory response, realize multiple-effect synergy of hemostasis, antibacterial, anti-inflammatory and antioxidant, and solve the limitation of a single-function hemostatic material.

1. Name of the Design Product: Air Pump Handle. 2. Use of the Design Product: The design product is used to provide a gas source so that the hemostatic powder can be applied to the wounds under systems such as laparoscopes and endoscopes. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective view.

The invention provides anti-inflammatory and healing-promoting hemostatic powder and a preparation method thereof. The rapid hemostatic powder is prepared from the following components in percentage by mass: 10 to 15 percent of cannabidiol, 4 to 8 percent of polyvinyl alcohol, 18 to 24 percent of polyacrylamide and the balance of quaternary ammonium salt-based chitosan. All the components are synergistically matched in proper mass percent, so that the effects of good blood compatibility and cell compatibility, fast gelling, high tissue adhesion and rapid hemostasis can be achieved. Meanwhile, the hemostatic powder has the advantages of good inflammation resistance and healing promotion. The hemostatic powder is suitable for accidents, operations and other scenes. In addition, the preparation method of the hemostatic material is simple and easy to implement, does not need to depend on complex processes and equipment, and is convenient for large-scale popularization.

The application discloses a fibrin-based hemostatic powder and a preparation method and application thereof. The hemostatic powder is prepared from fibrin and a hydrophilic biological macromolecule through in-situ blending, freeze-drying and grinding, and the hydrophilic biological macromolecule is one or more of carboxymethyl chitosan, epsilon-polylysine, gelatin and collagen. The hemostatic powder has a porous and loose microstructure, exhibits excellent powder forming property, rapid liquid absorption capacity (normal saline or blood) and strong hemostatic performance, and has a wide application prospect.

The application discloses a kind of multilayer nanostructure hemostatic powder and preparation method thereof, belong to the field of biomedical hemostatic material.To solve the problem of insufficient mechanical strength of existing silk fibroin-polyphenol hemostatic material, the silk fibroin solution is mixed with regenerated chitin nanofiber solution in proportion, and tea polyphenol solution is added dropwise to induce co-assembly and gelation, and the powder is prepared by washing, freeze-drying and grinding.The powder can quickly absorb water and self-gel after contacting with blood, and form a stable three-dimensional network hydrogel within a few seconds.The regenerated chitin nanofiber guides the formation of hierarchical nanostructure of silk fibroin through supramolecular interaction, significantly enhances the mechanical strength and adhesion, while tea polyphenol provides antibacterial, antioxidant and procoagulant functions.The hemostatic powder of the application has the functions of rapid hemostasis, strong adhesion in wet state, resistance to flushing and promotion of wound healing, and is suitable for various acute bleeding scenarios.

The utility model provides a finished product storage device for polysaccharide hemostatic material preparation, and relates to the field of polysaccharide hemostatic material finished product storage equipment, the finished product storage device comprises a storage assembly, the storage assembly comprises a support, a stock bin and a hopper, the stock bin is fixed at the upper end of the support, the hopper is fixed at the lower end of the support, the stock bin is communicated with an inner cavity of the hopper, and the storage assembly is connected with the storage assembly. A conveying assembly is arranged at the bottom of the hopper, a discharging assembly is installed on the surface of the hopper, and the discharging assembly comprises a protective cover, a second motor, a stirring shaft, a stirring rod, a driving gear, a driven gear, a transmission rod and a supporting rod; by arranging the discharging assembly, the effect of preventing accumulation of polysaccharide styptic powder during discharging is achieved, the stirring shaft rotates to drive the stirring rod to stir materials, the stirring rod stirs the materials, the flow rate of the polysaccharide styptic powder can be increased, and therefore the situation of blockage caused by accumulation can be prevented.

The invention relates to the technical field of styptic powder, in particular to adhesive styptic powder and a preparation method thereof.The adhesive styptic powder comprises oxidized dextran powder, gelatin powder and cross-linked methacrylated gelatin powder, and the weight ratio of the oxidized dextran powder to the gelatin powder to the cross-linked methacrylated gelatin powder is (0.2-1): (1-2): 1. Oxidized dextran is introduced to serve as a functional cross-linking agent, the aldehyde group oxidation degree of the oxidized dextran is accurately regulated and controlled, efficient and controllable reaction on gelatin amino is achieved, the adhesion capacity of the material to wet wounds is remarkably improved, methylacryloyl gelatin is introduced, and the adhesion capacity of the material to the wet wounds is remarkably improved by cooperatively controlling the methylacryloyl grafting degree, the pre-crosslinking degree and the three-component proportion of GelMA. Multiple action mechanisms of wound hemostasis and nursing are constructed; the cross-linked methacrylated gelatin treats early bleeding of the wound through imbibition swelling and blocking effects; after the oxidized dextran and the gelatin powder are dissolved, the oxidized dextran and the gelatin powder form an adhesive gel layer together with the cross-linked methacrylated gelatin, and the bleeding wound surface is firmly blocked.

The invention discloses composite quick-acting styptic powder. The composite quick-acting styptic powder comprises oxidized konjac glucomannan and hydrazide hyaluronic acid. The invention further provides a preparation method and application of the composite quick-acting styptic powder. The composite quick-acting styptic powder disclosed by the invention has excellent hemostasis and blood coagulation effects.

The invention relates to the technical field of hemostatic medicine preparation devices, in particular to a bio-fiber hemostatic powder preparation device. Comprising a base, a fixed plate mounted at the top of the base, a stirring piece rotationally connected to the top of the fixed plate, a scraper fixedly connected to the bottom of the stirring piece and tightly attached to the top surface of the fixed plate, a top plate rotationally connected to the top of the stirring piece through a bearing, and a stirring barrel slidably connected to the outer sides of the fixed plate and the top plate, sealed stirring of styptic powder can be achieved through lifting movement of the stirring barrel, discharging of the styptic powder can also be completed, meanwhile, residual powder in the stirring barrel can be further rapidly discharged in a mode of the air blowing assembly, and therefore the styptic powder discharging device is convenient to use and high in practicability. Residual powder on the inner wall of the stirring barrel and on the surface of the fixing plate by the scraper plate can be cleaned through the supporting frame, the efficiency of quickly taking out the powder is improved, and the styptic powder is prepared in a sealed state, so that the loss of raw materials for dispersing the powder outside can be reduced.

The invention relates to the technical field of biomedical materials, in particular to a preparation process of absorbable styptic powder for abdominal visceral organ surgery, which comprises the following steps: reacting natural polysaccharide with a cross-linking agent to form a polysaccharide substrate material, preparing porous microspheres through emulsification and curing, mixing the porous microspheres with a degradable polymer to obtain composite particles, and drying the composite particles to obtain the absorbable styptic powder for abdominal visceral organ surgery. And surface modification is carried out. By introducing the porous microsphere structure, the controllable degradable polymer and the surface modification technology, the water absorption performance, the degradation rate and the tissue adhesion stability of the hemostatic powder are remarkably improved, meanwhile, the production process is simplified, the cost is reduced, and the clinical requirements for efficient, safe and convenient hemostatic materials are met.

The invention relates to wound in-situ self-gelling multifunctional composite hemostatic powder and a preparation method thereof, and belongs to the field of biological materials, the method comprises the following steps: S1, preparing modified hyaluronic acid through an oxidation reaction and grafting dopamine hydrochloride, dialyzing, freeze-drying and grinding into powder; s2, preparing super-assembled mesoporous silica loaded with the analgesic drug, and drying and grinding the super-assembled mesoporous silica to form powder; s3, uniformly mixing the modified hyaluronic acid powder, the carboxymethyl chitosan powder and the super-assembled mesoporous silica powder according to different mass ratios to obtain the multifunctional composite styptic powder. The hemostatic powder prepared by the method is simple in process, low in cost and relatively high in biological safety. In addition, the hemostatic powder also has the excellent characteristics of rapid self-gelation, wet tissue adhesion, coagulation promotion, antibiosis, analgesia and wound repair promotion.

The invention discloses ionic cross-linked starch hemostatic powder and a preparation method and application thereof.The preparation method includes the steps that carboxymethyl starch with the substitution degree not smaller than 0.3 is dissolved in deionized water to be continuously stirred, a metal ion solution is quantitatively and dropwise added into the solution to obtain floccules, the floccules are centrifuged, washed and freeze-dried, and the ionic cross-linked starch hemostatic powder is obtained; the ionic cross-linked starch hemostatic powder is prepared. The preparation process is mild in reaction condition, a chemical cross-linking agent with poor biological safety is not needed, the process is simple and environment-friendly, and large-scale production is easy to realize.

A device for delivering an agent includes a valve assembly including a cavity for storing the agent and an agitation mechanism movably disposed inside the cavity. An inlet conduit fluidly coupled to a fluid source and the valve assembly. An outlet conduit fluidly coupled to the valve assembly, wherein the inlet and outlet conduit are each in fluid communication with the cavity. The agitation mechanism is configured to agitate the agent within the cavity in response to the agitation mechanism moving inside the cavity. The valve assembly is configured to urge the agitation mechanism to move inside the cavity in response to receiving a fluid from the fluid source via the inlet conduit, combine the fluid with the agent within the cavity in response to the agitation mechanism moving inside the cavity, and deliver a combination of the agent and the fluid out of the cavity through the outlet conduit.

The present invention discloses an enzyme-modified starch-based hemostatic powder and a preparation method thereof, belonging to the field of bio-modified starch. The steps are as follows: the starch is subjected to alkali washing, acid hydrolysis, and enzymatic hydrolysis and then loaded with procoagulant factors to obtain the starch-based hemostatic powder. The method only adopts processes such as stirring, heating, and filtration, with simple steps and convenient operation, and can conveniently achieve large-scale production. The starch-based hemostatic powder has a significant hemostatic effect. Compared with the products prepared by other methods, it has no potential toxicity risk to the human body. This method provides new ideas for the field of bio-modified starch and the field of medical hemostasis.

In aspects, the present application provides hemostatic powder compositions, and methods of making and using such powder compositions. For example, the present application provides hemostatic powder compositions, comprising a modified chitosan comprising covalently attached hydrophobic grafts and / or benzenediol groups, and optionally oxidized forms of the benzenediol groups, along the chitosan backbone.

The application relates to the technical field of collagen materials, and particularly discloses a collagen material, a preparation method thereof and application of the collagen material in collagen hemostatic powder. The preparation method of the collagen material is as follows: enzyme hydrolysis reaction: adjusting a raw material sample liquid to pH 3.5-6.0, adding a composite enzyme, carrying out enzyme hydrolysis at a temperature of 30-40 DEG C for 4-12 h, and centrifuging to obtain a supernatant; the composite enzyme is composed of trypsin and phospholipase in a weight ratio of 1-5:0.02-0.08; alkali treatment: adjusting the supernatant to pH>13, and carrying out alkali treatment at a temperature of 15-25 DEG C for more than 40 h; neutralization reaction: adjusting pH to 6.8-7.6, eluting, and removing water by extrusion, so that the collagen material is obtained. The application also provides application of the collagen material in the collagen hemostatic powder. The collagen hemostatic powder provided by the application has excellent hemostatic function and water absorption efficiency, and the hemostatic material has high stability.

The invention provides a solid wound hemostasis spider web band-aid for treating wound bleeding and a manufacturing method of the solid wound hemostasis spider web band-aid, and belongs to the technical field of band-aids. The band-aid comprises a medicine core covering film, a water-absorbable combined medicine core, a medical pressure-sensitive adhesive and an elastic cloth backing, the water-absorbable combined medicine core is arranged above the medicine core covering film, and the medical pressure-sensitive adhesive is arranged on the elastic cloth backing; the medical pressure-sensitive adhesive is arranged above the water-absorbable combined medicine core in a covering mode, and the elastic cloth backing is arranged above the medical pressure-sensitive adhesive. According to the invention, araneus cobweb and gold sore hemostatic powder is used, and the principle of araneus cobweb hemostasis in the aspect of current western medicine is perfectly applied: the araneus cobweb has high-efficiency water absorption, and the araneus cobweb has the functions of stopping bleeding and stopping gold sore bleeding due to the intelligent crystallization of ancient predecessor, the main liking function of araneus cobweb and the current western medicine; a substance named as' serine 'in araneus cobweb has a hemostasis effect and the araneus cobweb has high-efficiency water absorption; the hemostasis and tissue regeneration promoting prescription of the traditional Chinese medicine golden-skin-wound hemostasis powder is also found, effective hemostasis components or medicinal materials of the golden-skin-wound hemostasis powder and the golden-skin-wound hemostasis powder are extracted, Chinese and western are combined, innovation is combined, and the uniqueness of the product is embodied.

A device for delivering an agent includes a valve assembly including an enclosure for storing the agent, an agitation mechanism rotatably disposed inside the enclosure, and a tube disposed inside the enclosure and extending through the agitation mechanism. The tube includes a channel having a longitudinal length defined between a first opening at a first end of the tube and a second opening at a second end of the tube. The agitation mechanism is configured to direct a fluid received in the enclosure towards the agent stored therein in response to rotating about the tube, thereby agitating the agent within the enclosure. The tube is configured to receive a mixture of the fluid and the agent at the second opening and direct the mixture through the channel for delivery out of the enclosure via the first opening.

The application belongs to the technical field of biomedical materials, and particularly relates to a zwitterionic modified amino polysaccharide-based material, a preparation method and application thereof, and a hemostatic powder. The application provides a zwitterionic modified amino polysaccharide-based material, which comprises a zwitterionic modified amino polysaccharide-based polymer and oxidized hyaluronic acid; the zwitterionic modified amino polysaccharide-based polymer is obtained by reaction of an amino polysaccharide-based polymer and a zwitterionic monomer; and the mass ratio of the zwitterionic modified amino polysaccharide-based polymer to the oxidized hyaluronic acid is 3 / 1-1 / 3. The zwitterionic modified amino polysaccharide-based material provided by the application has excellent tissue adhesion performance, can effectively stay in a damaged area and block a wound, and has excellent water absorption / blood absorption performance, portability and a sprayable characteristic.

The utility model relates to the technical field of medical instruments, and discloses a novel hemostatic powder conveying system which comprises a spraying pipe and a Y-shaped three-way pipeline connected with the spraying pipe, the spraying pipe comprises a medicine injection opening, the side wall of the medicine injection opening is provided with a Luer connector communicated with the medicine injection opening, and the Y-shaped three-way pipeline is connected with the spraying pipe. According to the novel hemostatic powder conveying system, one path of gas in the Y-shaped three-way pipeline flows into a human body through the Luer taper and the catheter penetrating through the front working channel of the soft endoscope, at the moment, the hemostatic powder balloon is inserted into the position of the medicine injection port, and the medicine injection port is communicated with the medicine injection port. The balloon is extruded, the hemostatic powder is conveyed into the medicine injection opening, carbon dioxide gas is injected along with the Ruhr connector in the spraying pipe, and the hemostatic powder is rapidly injected into the bleeding part of a patient through the catheter, so that the aim of stopping bleeding is achieved, the treatment time is saved, and the pain of the patient is relieved.

A hemostatic biopsy tract article includes a bioresorbable body having a microporous structure. The bioresorbable body is formed by a mixture that includes a bioabsorbable hemostatic powder, a hydrolyzed starch, hyaluronic acid, and carboxymethylcellulose. Optionally, a marker element may be coupled to the bioresorbable body, wherein the marker element is formed from a material that is imageable under at least one imaging modality.

The invention relates to piezoelectric antibacterial supramolecular self-gel hemostatic powder as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials and wound repair. The piezoelectric antibacterial supramolecular self-gel hemostatic powder is prepared by drying and grinding hydrogel, and the hydrogel is prepared by uniformly dispersing nano-clay and piezoelectric nano-particles in a network structure formed by supermolecular interaction of a zwitterionic polymer and polyacrylic acid; the zwitterionic polymer is [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide. The hemostatic powder disclosed by the invention has excellent powder-gel reversibility and adjustable ultrasonic responsiveness, and a better solution is provided for acute bleeding treatment and infected wound healing.