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Starch compound polysaccharide hemostatic powder and preparation method thereof

A technology of compound polysaccharide and hemostatic powder, which is used in medical science, bandages, absorbent pads, etc., can solve the problems of poor adhesion, slow absorption, long degradation time, etc., and achieve good biocompatibility and degradability, Strong water absorption and swelling ability, enhance the effect of hemostasis

Inactive Publication Date: 2015-04-01
CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the hemostatic materials used clinically mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials, all of which have some shortcomings: collagen and gelatin, whose raw materials are derived from animals, have potential allergies, And the absorption rate is slow; cellulose, the human body lacks the enzymes to degrade it, and the degradation time is long, which may bring side effects such as infection to patients
At present, the representative starch hemostatic material is Arista hemostatic powder produced in the United States. Although its hemostatic effect is good, there are still shortcomings: first, it is cross-linked with epichlorohydrin, which has potential toxicity; second, the adhesion is not good; third, the price Expensive, which limits its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 80g of starch, 0.4g of α-amylase or glucoamylase, dissolve them in buffer respectively and blend them, react at 50±5°C, pH 3-6, and react for 24 hours to prepare a starch solution with a concentration of 25% by mass , standby; take 20g of sodium hyaluronate and dissolve it in deionized water to make a sodium hyaluronate solution with a mass percentage concentration of 1%, and set aside; mix and stir the prepared starch solution and sodium hyaluronate solution evenly, and then Freeze-drying; weigh a certain amount of calcium chloride, dissolve it in deionized water, and prepare a calcium chloride solution with a mass percentage concentration of 5%; soak the dried sample material in 5% calcium chloride solution for 2 hours, take it out, Rinse thoroughly with distilled water, freeze-dry, crush into powder, sterilize and sprinkle on the bleeding site, and apply directly to stop bleeding.

Embodiment 2

[0019] Weigh 90g of starch, 0.9g of α-amylase or glucoamylase, dissolve them in buffer respectively and blend them, react at 50±5°C, pH 3-6, and react for 24 hours to prepare a starch solution with a concentration of 25% by mass , set aside; take 10g sodium hyaluronate and dissolve it in deionized water to prepare a sodium hyaluronate solution with a mass percentage concentration of 1%, and set aside; mix and stir the prepared starch solution and sodium hyaluronate solution evenly, and then Freeze-drying; weigh a certain amount of calcium chloride, dissolve it in deionized water, and prepare a calcium chloride solution with a mass percentage concentration of 5%; soak the dried sample material in 5% calcium chloride solution for 2 hours, take it out, Rinse thoroughly with distilled water, freeze-dry, crush into powder, sterilize and sprinkle on the bleeding site, and apply directly to stop bleeding.

Embodiment 3

[0021] Weigh 90g of starch, 0.9g of α-amylase or glucoamylase, dissolve them in buffer respectively and blend them, react at 50±5°C, pH 3-6, and react for 24 hours to prepare a starch solution with a concentration of 30% by mass , set aside; take 10g of sodium hyaluronate and dissolve it in deionized water to make a sodium hyaluronate solution with a mass percentage concentration of 0.5%, and set aside; mix and stir the prepared starch solution and sodium hyaluronate solution evenly, and then Freeze-drying; weigh a certain amount of calcium chloride, dissolve it in deionized water, and prepare a calcium chloride solution with a mass percentage concentration of 5%; soak the dried sample material in 5% calcium chloride solution for 2 hours, take it out, Rinse thoroughly with distilled water, freeze-dry, crush into powder, sterilize and sprinkle on the bleeding site, and apply directly to stop bleeding.

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Abstract

The invention relates to starch compound polysaccharide hemostatic powder and a preparation method thereof. The preparation method comprises the following steps: carrying out enzymatic denaturation on starch to obtain a porous starch solution, dissolving sodium hyaluronate in deionized water to obtain a sodium hyaluronate solution, mixing the two solutions according to a weight ratio of 50-95 parts of porous starch solution to 5-50 parts of sodium hyaluronate solution, stirring uniformly and drying, soaking the dried material in a calcium chloride solution with a certain concentration to carry out ion exchange, and grinding the material into powder after secondary drying. The material provided by the invention has efficient stypticity on wound surfaces, is biodegradable, has the functions of anti-adhesion and moisture retention, and is safe and non-toxic, simple in preparation process and low in cost.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a starch composite polysaccharide hemostatic powder and a preparation method thereof. Background technique [0002] In medicine, bleeding refers to the accumulation of blood from the heart or blood vessels in a body cavity, interstitial space or out of the body. The normal human body has the function of hemostasis, and slow and small amount of bleeding can stop bleeding by its own function. However, for the phenomenon of massive bleeding in the human body in various sudden accidents and the hidden bleeding phenomenon of organ rupture, not only the body cannot stop bleeding by itself, but also surgery If the patient loses too much blood, it may cause shock and even endanger life and health. Therefore, rapid and effective hemostasis is required during the operation. Under normal circumstances, doctors usually need to adopt some hemostatic techniques to stop bleeding...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/42A61L15/60A61L15/50
Inventor 张大刘琼林玲
Owner CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
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