180results about How to "Achieve hemostasis" patented technology

The invention discloses a method for blocking up obstacle in coelom and a blocking device thereof. The blocking device comprises a guide wire, a guide tube and a blocking substance; one end of the guide wire penetrates the guide tube and cavity of the blocking substance; a remote end of the blocking substance is fixed to the guide wire, so as to pull a near end of the guide wire, thereby axially compressing the spread blocking substance to form a plug-shaped blocking object. The method of using the blocking device for blocking up obstacles in coelom is that the blocking substance in the coelom blocking device penetrates the obstacles in coelom, a near end of the guide wire is pulled, and the spread blocking substance is axially compressed to form a plug-shaped blocking object to block up the obstacles. The method for blocking up obstacle in coelom of the invention sets up a special coelom blocking device to block up and fix obstacles, such as thrombus and stone in coelom, and removes the obstacles according to practical requirements. The method for blocking up obstacle in coelom has tiny structure, simple operation, convenient use and high efficiency.

The invention discloses a preparation method and the production process of a complex injection of 13 vitamins. The injection adopts dual-injection type, the invention overcomes the problem of solubility of the fat-soluble vitamins in water, so the invention can be prepared into the water injection; the stability of the product is good, and various vitamins can not be affected mutually. The injection includes water-soluble vitamins, fat-soluble vitamins, surfactant, antioxidant, complexing agent and solvent, the injection water is added till the dissolution, the activated carbon is added for absorption, the pH value of the solution is regulated, and then the nitrogen filling and sterilization are carried out. The production process of the invention prepares the injection into dual-injection type, the vitamin B12, folic acid and biotin have an independent package, the process overcomes the problem of solubility of fat-soluble vitamins in water, the invention can be prepared into water injection, the stability of the product is good, and various vitamins can not be affected mutually, the vitamins can be added in a large infusion for usage, so as to avoid the trouble of redissolution and reuse of the freeze-dried powder injection.

Some embodiments of the invention provide an apparatus for achieving hemostasis in a puncture tract. Such a tract might have been created during a medical procedure, operation or a traumatic injury. In some embodiments, the apparatus includes a bandage for placement within the puncture tract. The apparatus also includes a stem with a distal end. In some embodiments, the bandage couples to the distal end of the stem. In other embodiments, the bandage couples to the entire length of the stem. Along with the bandage, the stem's distal end is at least partially inserted into the puncture tract in some embodiments. In other embodiments, only the bandage is inserted into the puncture tract. The bandage is typically maintained within the puncture tract until hemostasis is achieved. Once hemostasis has been achieved, the operator removes the bandage from the puncture tract.

An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue / organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue / organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.

The invention provides a preparation method for an oxidized regenerated cellulose hemostatic material with a surface nanostructure. In order to solve problems of small specific surface area, water insolubility, single hemostatic effect mechanism and low hemostatic speed of the traditional oxidized cellulose hemostatic material, the invention provides the preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The method comprises the following steps of: (1) preparing a collagen aqueous solution; (2) preparing a viscose fiber gauze; (3) preparing oxidized viscose staple fiber and oxidized viscose fiber gauze; (4) preparing an oxidized regenerated cellulose sodium solution or an oxidized regenerated cellulose potassium solution; (5) preparing an oxidized regenerated cellulose gauze; and (6) after collagen particles are sprayed, freezing and drying the oxidized regenerated cellulose gauze, so as to finish the preparation of the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure, provided by the invention, is applied to the preparation field of the oxidized regenerated cellulose hemostatic materials.

The invention discloses a preparation method of a quick absorption saturation gelation seaweed hemostatic dressing. The method includes the steps of: soaking, rinsing and drying on calcium fiber textile or non-woven products containing alginate, and the carrying out cutting, packaging and sterilizing to obtain the quick absorption saturation gelation hemostatic dressing. The invention also discloses the application of the quick absorption saturation gelation seaweed hemostatic dressing prepared by the above method. The invention is applicable to rapid absorption and removal of a large amount of surgical diffusate in surgical operation process, so as to realize the effects of rapid hemostasis and operation wound clean; the hemostatic dressing is used for burn, scald and other acute and chronic wounds, can cover the wound and prevent moisture loss in body fluids, provide a positive moist environment for wound healing, prevent the wound from effusion and erosion, isolate bacterial infection, and play the effects of stopping bleeding, relieving pain, promoting wound healing, and reducing scar.

The invention provides a multifunctional electrostatic spinning fiber dressing and a preparation method thereof, and belongs to the technical field of polymer medical materials. The fiber dressing isof a micro-nano structure, the electrostatic spinning method is adopted for spinning polymer materials with grafted functional groups into fiber, then, crosslinking is performed to obtain the fiber dressing, and the polymer materials have the function of stimulating macrophage transition. The invention further provides the preparation method of the multifunctional electrostatic spinning fiber dressing. The electrostatic spinning fiber dressing is obtained by grafting functional groups to polymer materials capable of promoting macrophage transition and then performing electrostatic spinning andcrosslinking, the fiber is soft and easy to fold and can well fit a superficial wound, a deep wound can also be filled with the fiber, and the fiber can achieve the multiple functions of stopping bleeding, resisting oxidation, resisting inflammation, resisting bacteria, promoting healing and reducing scars.

The invention relates to a wound dressing with a multi-layer structure and a preparing method and application thereof. The wound dressing at least comprises a liquid conduction layer and a liquid storage layer, wherein the transverse wet conduction speed of the liquid storage layer is larger than the transverse wet conduction speeds of other layers; the wound-secreted-liquid hygroscopicity of thewound dressing is larger than 50 grams / 100 square centimeters. By means of the wound dressing, it can be effectively avoided that wound percolated liquid is transversely diffused to the peripheral healthy skin of a wound to cause the condition that the healthy skin is injured, and the wound dressing is suitable for nursing of an ulcerous wound and a chronic wound and compression hemostasis.

The invention relates to a starch composite hemostatic dressing of mesoporous silica microspheres, which adopts a sol-gel method and uses a three-block copolymer pluronic as a template agent to synthesize mesoporous silica microspheres with a pore diameter of about 5 nm. It is compounded with starch to prepare a mesoporous silicon oxide microsphere / starch composite hemostatic dressing, and the hemostatic performance of the composite material is observed through animal experiments. The mesoporous silica microsphere / starch composite material not only has strong water absorption performance, but also has obvious in vitro coagulation performance, which can significantly shorten the partial thromboplastin time and prothrombin time. The mesoporous silica microsphere / starch composite material can prevent the bleeding of the rabbit's back skin and liver injury and shorten the bleeding time, and has obvious hemostatic effect.

The invention provides gelatine-PCL (posterior cruciate ligament) dental hemostatic sponge and a preparation method thereof. The preparation method comprises the following steps of: firstly, stirring a gelatine solution with the mass fraction of 5-20% with a PCL solution with the mass fraction of 10-20% at the temperature of 25-60 DEG C to react for 1-5 hours so as to prepare a combined solution, then adding auxiliary additives to the combined solution, continuously stirring for 1-3 hours at the temperature of 25-60 DEG C to prepare a mixed solution, pouring the mixed solution into a mould, freezing for 0.5-4 hours at the temperature of minus 20 DEG C, and finally freeze drying and moulding in a freeze drying machine to obtain the gelatine-PCL hemostatic sponge. The gelatine-PCL hemostatic sponge prepared by the invention has good retention property, hemostatic property and anti-inflammatory bacteriostatic effect; the product is safe and effective without toxic or side effect; waste can be degraded without causing environmental pollution; and the gelatine-PCL hemostatic sponge can be widely applied as a postoperation hemostatic material for dental extraction and other oral surgeries and has a good market application prospect.

The invention relates to macromolecule hydrogel dry glue sponge with super water absorption, and a preparation method and application thereof. The sponge is stereoscopic netted porous sponge which takes chitosan as a framework, a super hydroscopic polymer as a branch chain and a macromolecule or polymer with a flexible structure as a cross-linking agent. The sponge is prepared through a one-pot process. The product has a porous structure and a super hydroscopic feature; after the sponge absorbs water, an overall structure and a certain mechanical strength are still kept; the material can be used for first-aid hemostasis of larger arteriovenous hemorrhage; and the effect is better than that of the present material in the market. The macromolecule hydrogel dry glue sponge with super water absorption, provided by the invention, has the advantages of simple preparation process, low cost, obvious hemostatic effect, high safety, no heat generation, no residue, obvious medical value and industrial potential.

The invention discloses a preparation method of a drug-loaded sodium alginate / gelatin composite hydrogel band-aid. The method comprises the following steps: (1) mixing sodium alginate and a gelatin solution, and preparing sodium alginate / gelatin composite hydrogel by utilizing the characteristics of cross-linking between calcium ions and sodium alginate and cross-linking between glutamine transferase and gelatin; and (2) preparing the drug-loaded sodium alginate / gelatin composite hydrogel band-aid: loading a drug into the composite hydrogel, so that the finally prepared band-aid has the effects of resisting bacteria, diminishing inflammation and promoting wound healing. The drug-loaded sodium alginate / gelatin composite hydrogel band-aid is successfully prepared, the raw materials adopted in the preparation process are all non-toxic compounds, the preparation process is simple, and the cost is low. Experimental tests show that the composite hydrogel is of a porous structure and is beneficial to gas exchange; the swelling property is beneficial to absorption of exudate of the wound; and berberine serving as a drug model is successfully loaded into the composite hydrogel and can be slowly released, so that the composite hydrogel has an antibacterial effect.

The invention discloses an inductive uterine slow release system. The incidence of uterine adhesion after an induced abortion operation is high, the re-adhesion is serious after a uterine adhesion operation, and no good solution is available at present. The system comprises a uterus-shaped elastic balloon stent, a slow release drug film, a catheter and a one-way inflation valve, wherein the uterus-shaped elastic balloon stent is a hollow isosceles triangle structural body; waists of the isosceles triangle are 3.5cm; the bottom edge of the isosceles triangle is 3cm; one end of the catheter is connected and communicated with the vertex angle end of the uterus-shaped elastic balloon stent; the other end of the catheter is connected with the one-way inflation valve; a plurality of annular scales are arranged on the outer side face of one end, close to the uterus-shaped elastic balloon stent, of the catheter; and the one-way inflation valve comprises an inflation valve and a pressure sensor. The uterus-shaped elastic balloon stent is coated with the slow release drug film, and the slow release drug film is made of fibrin glue and contains a slow release drug. The system is simple in structure and easy to operate, does not injure a uterine cavity easily, and can effectively avoid the uterine adhesion.

The invention relates to the technical field of medical anesthesia, in particular to a medical analgesic and hemostatic dressing for anesthesiology department and a preparation method of the medical analgesic and hemostatic dressing. The dressing comprises a non-woven fabric surface layer, a water absorbing middle layer and a functional bottom layer from top to bottom, wherein the water absorbingmiddle layer is a compressed modified loofah sponge, and pores of the modified loofah sponge are filled with modified sepiolite and modified chitosan; the functional bottom layer is hydrogel doped with an analgesic. The preparation method of the dressing comprises the following steps: the functional bottom layer and the water absorbing middle layer are expanded and overlapped to be placed into a needling machine for needling, and then the non-woven fabric surface layer is placed on the water absorbing middle layer in an overlapping manner for needling. The medical analgesic and hemostatic dressing can stop bleeding rapidly, can also realize sedative and analgesic effects and has good biocompatibility and biodegradability.

The invention relates to novel antibacterial restorative functional dressing and a preparation method thereof. The novel antibacterial restorative functional dressing is formed by crosslinking and compounding chitosan and collagen on a bacterial cellulose membrane through a cross-linking agent, wherein a mass ratio of the chitosan to the bacterial cellulose membrane is (0.001-5) to 100; a mass ratio of collagen to the bacterial cellulose membrane is (0.5-20) to 100; a mass ratio of the chitosan to the collagen is (0.001-5) to (20-0.5); and the collagen is a mixture of collagen with small molecular weight and collagen with large molecular weight according to a ratio of 1 to 1. The antibacterial restorative functional dressing has very good biocompatibility, cellular affinity and mechanical property, has excellent water-permeable, gas-permeable or drainage and moisture absorption effect, has the effects of realizing antisepsis and anti-inflammation, reducing wound infection and quickly relieving pain of the wound, and has the effects of relieving chromatosis and promoting the wound to heal during a wound healing period. Meanwhile, the dressing can naturally drop along with epithelial regeneration, so that the treatment time and cost is reduced, and the wound infection probability is reduced.

The invention discloses a starch-based microporous hemostatic material having antibacterial function, and a preparation method and an application of the material. The preparation method includes the steps of: preparing starch-based microporous starch; and supporting amino group ions on the microporous starch to finally produce the electro-positive starch-based microporous hemostatic material, which is 0.1-6 [mu]m in pore diameter, is 20-240 s in hemostatic time, reaches 50-100% in antibacterial rate and can be completely degraded in 4-240 h in vivo. The material can quickly and effective stop bleeding and also has antibacterial function, so that the material can prevent infection on a wound and accelerate healing of the wound without damage on normal cells. In the invention, starch, which has wide sources and low cost, is used as a raw material; the starch is subjected to micropore forming and then supports the amino group, thereby producing the hemostatic material having physical and chemical hemostatic mechanisms. The material can rapidly stop bleeding, has high stickiness and good biocompatibility, is quick to degrade in vivo, is wide in available range and has hemostatic and antibacterial functions at the same time.

The invention discloses a tourniquet which comprises a silicone rubber ring, an elastic band and a nylon stretching strap, the silicone rubber ring is in a bracelet shape, and is rolled in the elastic band, which is made of spandex through winding, its upper end is connected with the silicone rubber ring. The purpose of haemostasis is achieved for the limb position below the silicone rubber ring through the elasticity of the silicon rubber ring.

A multi-component biochemical medicine with blood coagulating action for treating hemorrhage is prepared through extracting it from venin and is composed of thrombin-like enzyme and thrombin-like kinase. Said thrombin-like enzyme is the styptic norfibrase. Said thrombin-like kinase is the activator of blood coagulating X factor for activating the X factor in plasm to Xa and converting the thrombinogen to thrombase to treat hemorrhage.

The invention relates to a hemostasis spraying type adhesive and a preparation method thereof. The method comprises the following steps: preparing an adhesive solution; preparing nanometer grains; preparing an amine chitosan derivative; preparing the final adhesive. The adhesive prepared according to the method has the advantages that the gelation time required by adhesion is short, the mechanical strength is excellent, the bleeding can be quickly stopped and the adhesive also has quick and strong adhering property even under the existence of water.

The invention discloses a bleeding stop needle core and a biopsy needle. The bleeding stop needle core comprises a positive pole rod, a first insulation sleeve, a negative pole sleeve, an insulation spacer, a second insulation sleeve and a guide wire, wherein the positive pole rod is provided with a major diameter radio frequency end head and a minor diameter electric conduction pillar, the first insulation sleeve sleeves the outer wall of the minor diameter electric conduction pillar, the negative pole sleeve sleeves the first insulation sleeve, the insulation spacer sleeves the first insulation sleeve or the minor diameter electric conduction pillar, two ends of the insulation spacer are respectively pressed against the major diameter radio frequency end head and the negative pole sleeve, the second insulation sleeve sleeves the outer wall of the negative pole sleeve, and the guide wire is used to respectively communicate the positive pole rod and the negative pole sleeve with a radio frequency source. According to the bleeding stop needle core, the positive pole rod and the negative pole sleeve are electrically connected with the radio frequency source through the guide wire, the major diameter radio frequency end head generates radio frequency of corresponding frequency, tissue molecules around a needle passage are vibrated and rubbed at high speed, and generate heat energy, a bleeding stop function is achieved by rapidly shrinking vascular tissue surfaces of a wound surface around the needle passage, and a thermal insulating layer is arranged so as to effectively prevent other tissue from being injured due to heat propagation when the bleeding stop needle core works.

The present invention relates to a wates-soluble aerosol made up by using chitosan as main raw material and a chitosan wound mounting block made up by using basic layer, skeleton layer and mounting layer through a certain hot-pressing and integrally-forming process. The nano-grade oligosaccharide in the aerosol is a chitosan wound healing agent with bio-activity, the polyvinyl alcohol is the hydrophilic thickening, film-forming and slow release agent and the glycerine is the flexibilizing and toughening agent of polyvinyl alcohol medicine film.

Laser treatment of tissue, particularly the tissues in or around the nasal and oral cavities, are described herein. One method for reducing the size of the tissue being treated is to apply laser energy to the underlying tissue. One instrument may be used to deliver laser energy and to optionally provide an infusion or injection of a fluid directly into the tissue as well as optionally provide for ultrasound energy application as well. One or more optical fibers which may extend through needles inserted into the tissue may be utilized to deliver the laser energy.

The invention discloses an auxiliary blood sampling robot and belongs to the technical field of medical devices. The auxiliary blood sampling robot can conveniently find blood vessels and is high in puncture successful rate. According to the technical scheme, the auxiliary blood sampling robot comprises a vein pressing device and an elbow pad device. A through hole for a hand to penetrate is formed in the end face of the vein pressing device, an air bag used for vein pressing is arranged on the side wall of the through hole, and the air bag is communicated with a gas storage tank through a gas inlet pipeline and a gas exhaust pipeline. The vein pressing device is further provided with a vein developing instrument. The auxiliary blood sampling robot is suitable for being used for vein puncture blood sampling.

The invention discloses a mammary gland biopsy excision blood coagulation device with a radio frequency coagulation cutter tube. The device comprises an outer tube rotating gear, a linear driving gear, a radio frequency electric connecting piece, a sample collector, a vacuum catheter kit, a puncture cutter, a sampling groove, an outer tube, a cutting knife tube, an indicating shaft sleeve, a connecting piece and an outer tube rotating device. According to the invention, the cutting edge part of the cutting knife tube is changed into a surgical electrode of a radio frequency coagulation cuttingdevice, radio frequency current passes through the cutting edge of the cutting knife tube and is conducted to pathological tissues to be cut, and bleeding is stopped while the tissues are cut. Because the cutting is not a mechanical mode, the problem that a cutting edge becomes blunt does not exist. Meanwhile, calcification points can be crushed through spark discharge. A heat affected zone generated by discharge energy can play a blood coagulation effect.

The invention discloses a method for preparing a quick hemostatic dressing. The method comprises the following steps: 1, firstly, taking sodium carboxymethyl cellulose, carboxymethyl chitosan, polyethylene glycol and guar gum, grinding the bone of squid into powder, and evenly mixing the raw materials at the normal temperature to form a mixture A; 2, vibrating the mixture A obtained in the step 1 by a vibrating screen and then evenly pasting the mixture A on an adhesive medical tape; 3, cutting calcium alginate fiber and chitosan fiber into short fiber respectively, evenly mixing the short fiber, and punching the short fiber by a needle to form non-woven fabrics; and 4, covering the non-woven fabrics on the surface of the medical tape stuck with the mixture A, and finally forming a finished product. The quick hemostatic dressing has the advantages of low manufacturing cost, easy degradation, good hemostatic effect, and convenient use by a patient.

The invention relates to starch compound polysaccharide hemostatic powder and a preparation method thereof. The preparation method comprises the following steps: carrying out enzymatic denaturation on starch to obtain a porous starch solution, dissolving sodium hyaluronate in deionized water to obtain a sodium hyaluronate solution, mixing the two solutions according to a weight ratio of 50-95 parts of porous starch solution to 5-50 parts of sodium hyaluronate solution, stirring uniformly and drying, soaking the dried material in a calcium chloride solution with a certain concentration to carry out ion exchange, and grinding the material into powder after secondary drying. The material provided by the invention has efficient stypticity on wound surfaces, is biodegradable, has the functions of anti-adhesion and moisture retention, and is safe and non-toxic, simple in preparation process and low in cost.

The invention discloses a pair of positioning suture hemostatic forceps, and belongs to medical devices. The pair of positioning suture hemostatic forceps comprises a handle and a clamping head, wherein the handle comprises a handle body I and a handle body II which are movably connected with each other through a rotating shaft and can be closed or opened along the rotating shaft; the clamping head comprises a first clamping head plate body and a second clamping head plate body which are arranged in the way of corresponding to the front ends of the handle body I and the handle body II; the first clamping head plate body and the second clamping head plate body can be driven by the handle body I and the handle body II to close or open; and a blood vessel protection cavity is formed between the two clamping head plate bodies which are closed, and the two clamping head plate bodies which extend towards on side of the blood vessel protection cavity are in a closed state, a plurality of needle hole openings are arrayed on the two clamping head plate bodies which are closed, and projections are respectively formed on the opposite surfaces of the two clamping head plate bodies on one sides, which are far from the blood vessel protection cavity, of the needle hole openings. According to the positioning suture hemostatic forceps, the blood vessel protection cavity which is arranged through the clamping head, the plurality of needle hole openings and the opposite projections are utilized, so that multiple functions of positioning, bleeding stopping and suturing are realized at the same time, and thus, surgical use requirements are well satisfied.

The invention provides a collagen-polycaprolactone (PCL) dental hemostatic sponge and a preparation method thereof. The method comprises the following steps of: blending 0.2 to 1 mass percent of collagen solution and 0.5 to 10 mass percent of PCL solution, stirring at the temperature of between 1 and 30DEG C, reacting for 1 to 6 hours to obtain complex liquid; adding auxiliaries into the complex liquid, continuously stirring at the temperature of between 1 and 30DEG C for 1 to 4 hours to obtain a mixed solution; pouring the mixed solution into a mold, freezing at the temperature of -20DEG C for 0.5 to 4 hours; and performing freeze drying in a freezer dryer to obtain the collagen-PCL hemostatic sponge. The collagen-PCL hemostatic sponge prepared by the method has good retention ability, hemostasia, anti-inflammatory and antibacterial property and biocompatibility, is effective and safe without toxic or side effect, can be widely used as a postoperative hemostatic material for exodontias and other oral surgeries and has good market application prospect; and waste can be degraded and cannot pollute environment.

The invention discloses a stancher and a preparation method thereof. The stancher comprises the following components by weight: 1.5 to 15 portions of aizoon stonecrop root, 3.5 to 35 portions of bletilla striata, 3.5 to 35 portions of parched Pollen Typhae, 2 to 20 portions of sanguisorba carbon, 3.5 to 35 portions of crinis carbonisatus, 5 to 50 portions of red madder root, 2 to 20 portions of frankincense, 2 to 20 portions of myrrh, 1.5 to 15 portions of dragon's blood, 5 to 50 portions of halloysitum rubrum, 5 to 50 portions of drgon's bones and 0.3 to 3 portions of borneol. The stancher has the advantages of high healing effect, convenient use, fast blood assuaging, pain assuaging, tissue regeneration promoting and healing, low medical treatment cost, and the like, the preparation method is simple, and the usage of the stancher is convenient.

The invention relates to an aminomethylbenzoic acid freeze-dried powder injection medicine composition for injection. Specifically, on one hand, the invention relates to a freeze-dried powder injection medicine composition. The freeze-dried powder injection medicine composition contains aminomethylbenzoic acid, a freeze-drying excipient such as mannitol, and an optional acid-base regulator; the freeze-drying excipient is selected from saccharose, glucose, mannitol, lactose, sorbitol and glycine, and the weight ratio of the aminomethylbenzoic acid to the freeze-drying excipient is 100: (50 to 500). On the other hand, the invention further relates to a method for preparing the aminomethylbenzoic acid freeze-dried powder injection medicine composition, wherein the method is carried out according to a conventional freeze-dried powder injection medicine preparation method. The aminomethylbenzoic acid freeze-dried powder injection medicine composition for injection disclosed by the invention can be used for treating such bleeding caused by excessive primary fibrinolysis as acute and chronic, local or general high fibrinolytic bleeding which is common in carcinoma, leukaemia, gynaecology and obstetrics accidences, serious liver disease bleeding and the like, and anticipated good properties can be achieved.