44 results about "Needle biopsy" patented technology

The utility model relates to a needle biopsy mechanism, which relates to the field of prostate needle biopsy, and comprises a biopsy gun guide assembly, a lifting assembly, a linear motion assembly and a rotating assembly, when puncture is carried out, the biopsy gun guiding assembly and a linear probe imaging plane in the ultrasonic probe need to be coplanar so that a needle of the biopsy gun guiding assembly can be completely seen in the plane; the biopsy gun guide assembly is guided by the biopsy gun guide assembly to penetrate into a biopsy position; the lifting assembly is connected with the biopsy gun guiding assembly and used for driving the biopsy gun guiding assembly to be close to or away from the ultrasonic probe in the plane. The linear motion assembly is connected with the lifting assembly and used for driving the biopsy gun guiding assembly to be close to the perineum part so that the biopsy gun guiding assembly can conveniently conduct puncture through a guiding hole of the guiding device. The rotating assembly is connected with the linear motion assembly and used for driving the biopsy gun guiding assembly to do circular motion around the axis of the ultrasonic probe. According to the invention, the prostate lesion point corresponding to the to-be-detected area can be better punctured.

The invention relates to a pulmonary nodule minimally invasive needle biopsy excision device, and relates to the technical field of medical instruments. The system comprises a mechanical arm electrically connected with CT equipment, navigation auxiliary equipment, a puncture assembly detachably connected with the mechanical arm and used for puncturing human tissue, a sampling assembly for sampling tissue at a nodule and a marking assembly for marking the sampling position; the puncture assembly comprises a mounting base detachably connected with the mechanical arm and a puncture needle arranged on the mounting base, and the end of the puncture needle is sharp. The puncture needle is arranged in a hollow mode, the sampling assembly comprises a rotary cutting cylinder rotationally arranged in the puncture needle and a power part for driving the rotary cutting cylinder to rotate, a first rotary cutting opening is formed in the puncture needle, a second rotary cutting opening is formed in the rotary cutting cylinder, and the first rotary cutting opening movably corresponds to the second rotary cutting opening. The biopsy sampling device has the advantages that the sampling amount of each biopsy sampling is conveniently increased, the puncture sampling frequency is reduced, and meanwhile the radiation dosage is reduced.

The utility model relates to the technical field of puncture needles, in particular to a medical electric puncture biopsy needle which comprises a handle and a driving mechanism fixedly connected with the handle, the driving mechanism comprises a shell and a motor located in the shell, the output end of the motor is fixedly connected with a connecting piece, the connecting piece is detachably connected with a puncture needle assembly, and the puncture needle assembly is fixedly connected with the handle. And a battery assembly for supplying power to the motor is arranged in the handle. According to the electric puncture needle, when bone puncture operation is carried out, a puncture doctor needs to hold a handle, the handle is mainly used for controlling the direction and exerting certain pressure, a needle sleeve and a needle core are driven by a motor to rotate left and right rapidly and cut bone tissue continuously, the puncture accuracy can be greatly improved, the time is greatly shortened, and the puncture efficiency is greatly improved. Meanwhile, physical exhaustion of doctors is relieved, operative complications can be greatly reduced, and benefits are brought to the majority of patients.

The invention relates to the technical field of oral system disease diagnosis, in particular to an oral system onset risk prediction method and system. By combining the five groups of indexes, early evaluation can be effectively performed on the oral cancer, score data reflecting the oral cancer can be obtained, and the grade of the oral cancer and the corresponding deterioration degree can be more intuitively determined through the score data. Compared with an existing method, the method has the advantages that the evaluation result of the patient can be accurately obtained based on a non-needle biopsy means, and the accuracy of the evaluation result is high based on multiple types of indexes.

The invention provides needle biopsy equipment for the liver department, and belongs to the field of inspection equipment. Comprising a mounting plate and a master control module. The mounting plate is arranged in a [shape, a main control module is mounted on the outer side wall of the mounting plate, a fixing and locking assembly is arranged in the mounting plate, a connecting plate is arranged on the upper side of the mounting plate, the connecting plate is arranged in an L shape and movably connected with two mounting shells, displacement adjusting assemblies are arranged on the mounting shells, and the displacement adjusting assemblies are movably connected with the mounting shells. And one side of the mounting shell on the upper side is fixedly connected with a fixing ring, and a spherical shell is assembled in the fixing ring. By arranging the displacement adjusting assembly and the angle driving assembly, through driving of a first motor and a second motor, a puncture needle can be rapidly adjusted to the designated position of the body of a patient, and by controlling third motors at different positions, the rotating position of a spherical shell can be adjusted by a driving wheel; therefore, the puncture needle can be accurately adjusted to a specified angle, and the puncture precision is improved.

The invention provides a same-layer registration method for an MR cross section diagram and a total tumor pathological section based on 3D printing. The same-layer registration method comprises the steps of obtaining an MR image, extracting an interested volume, designing a 3D printing mold matched with a focus in shape and assisting registration of a pathological section and the MR image. MR image layering thickness information is embedded into mold design, the thickness of a mold section is consistent with the thickness of an MR scanning layer, and direction information is marked in a mold to ensure spatial alignment of a pathological section and an MR image. The manufactured pathological section is accurately matched with an MR cross section diagram through a non-rigid image registration algorithm, and layer-by-layer comparative analysis of a tumor image and pathology is achieved. The whole tumor area can be covered, and registration errors caused by needle biopsy limitation, tissue deformation and resolution difference in the prior art are overcome. The method is high in applicability and can be used for image-pathology conjoint analysis of various types of tumors, the registration precision is remarkably improved, the error is controlled within 0.1 mm, and important support is provided for tumor research and accurate diagnosis.

The utility model discloses a coaxial puncture needle which comprises an outer tube and an inner core needle, a clamping cap is arranged at the rear end of the inner core needle, a clamping head is arranged at the rear end of the outer tube, the clamping cap and the clamping head can be connected in a clamped mode, the inner core needle is arranged in the outer tube in a penetrating mode from back to front till the clamping head and the clamping cap are connected in a clamped mode, and at the moment, the head of the front end of the inner core needle extends out of the front end of the outer tube. The head of the front end of the inner core needle is composed of a needle tip section and a spin locking section located behind the needle tip section, the taper angle of the needle tip section is 9-15 degrees, and external threads are arranged on the side wall of the spin locking section. According to the coaxial puncture needle, due to the facts that the tip end of the head of the front end of the inner core needle is arranged to be in a pointed cone shape, the side face of the spin locking section is provided with the external threads, and the edge of the front end opening of the outer tube is machined into the cutting edge, the probability that a focus is pushed and disengaged from the needle point is reduced, and the success rate of needle biopsy is increased.

The invention provides a kidney needle biopsy quantitative teaching evaluation system and method based on mixed reality, and the system comprises a virtual-real space registration unit which is used for building the space mapping between a virtual kidney model containing a renal cortex layered anatomical structure and a simulation entity training model body, and completing the space registration of the virtual model and the entity model body; the operation data acquisition module is used for acquiring three-dimensional motion trail data of the puncture needle in the puncture operation process; according to the quantitative scoring module, the multi-dimensional weighted scoring model takes the cortical ratio as a core evaluation index, and the scoring dimension corresponding to the cortical ratio has the highest weight in the model; the quantitative scoring module calculates a cortical ratio based on the acquired three-dimensional motion trail data, and outputs an operation quantitative score through a multi-dimensional weighted scoring model; and the closed-loop verification unit is used for acquiring a real puncture result on the simulation entity training die body and comparing the real puncture result with the puncture track subjected to virtual calculation so as to calibrate the operation quantitative score.

The invention provides a short-needle-point rotary-cut type thick needle biopsy device which comprises a needle head structure, the needle head structure comprises an outer needle tube, a rotary-cut structure is rotatably connected in the outer needle tube, the rotary-cut structure comprises an inner needle tube, and the inner needle tube is rotatably arranged in the outer needle tube; an assembling structure is arranged at the top end of the needle head structure, a pneumatic structure is arranged in the assembling structure, the bottom end of the pneumatic structure is embedded into the inner needle tube, the pneumatic structure comprises a sealing cover, and an exhaust mechanism is fixedly installed in the middle of the sealing cover. By shortening the length of the tip of the needle core, the risk that the needle tip mistakenly enters adjacent important organs is remarkably reduced, a new sampling mechanism is adopted, displacement errors caused by forward pushing of the needle in traditional biopsy are avoided, uniform and continuous tissue cutting can be achieved, it is ensured that the obtained specimen is complete in shape, pathological diagnosis is facilitated, and the clinical application prospect is wide. Rapid sampling of tissues in areas difficult to operate and separate is ensured, so that puncture can be carried out in lesion areas closer to important structures, and the application range of the CNB technology is expanded.

The invention, which belongs to the technical field of the teaching system, discloses an interactive needle biopsy teaching system comprising a teaching unit, an assessment unit, a VR unit and a puncture operation unit. The teaching unit is in communication connection with the assessment unit, the VR unit and the puncture operation unit; the teaching unit is used for login of a user, storage of multiple VR teaching materials, selection of the VR teaching materials of the user and storage of a teaching progress; each VR teaching material is matched with a puncture model; the puncture operation unit is used for simulating puncture biopsy operation; the assessment unit is used for checking puncture assessment by a user and assessing simulated puncture biopsy operation; the VR unit is used for playing VR teaching materials and collecting real-time image data of simulated needle biopsy operation. Through the above mode, the user can carry out immersive learning and operation simulation on the VR teaching materials based on the VR unit.

The invention provides a coaxial puncture needle beneficial to implantation of gelatin sponge, which comprises a needle tube assembly and a needle rod assembly, and the needle rod assembly is nested in the needle tube assembly; the needle tube assembly comprises a needle tube body and a needle base, the needle base and the needle tube body are arranged in a sleeved mode, and the needle rod assembly penetrates into the needle base and the needle tube body. A horn mouth is formed in the end, away from the needle tube body, of the needle base and used for the needle rod assembly to plug the gelatin sponge into the needle tube body. A visible window is formed in the connecting portion of the needle tube body and the needle base. The needle has the advantages that the flat-head needle rod is additionally arranged on the basis of an original pointed-head needle rod, gelatin sponge is conveniently stuffed into the coaxial needle through the flat-head needle rod, the aim of stopping bleeding rapidly, conveniently and effectively is achieved, and the most common complication bleeding in needle biopsy is greatly reduced.

An inner core is telescopically arranged in a needle tube, one end of the needle tube is concentrically fixed to a sleeve through a Luer taper, a needle head is arranged at the other end of the needle tube, the rear section of the needle tube is sleeved with a boosting tube, the front section of the needle tube is sleeved with a sheath tube, and the needle head extends out of the sheath tube. The sheath tube is arranged at the front end of the core rod through the end socket fixing seat, the front section of the core rod is sleeved with an adjusting cylinder in a sliding mode, the rear section of the core rod is sleeved with the sleeve in a sliding mode, an adjusting ring is arranged between the adjusting cylinder and the sleeve, a first adjusting screw is arranged between the adjusting ring and the core rod, and a second adjusting screw is arranged on the side portion of the adjusting cylinder. The ultrasonic needle biopsy needle is convenient to use, wider in applicability and capable of effectively improving the sampling effect.

The utility model discloses a positioning device for improving the coincidence rate of breast ultrasound and molybdenum target diagnosis, which comprises a silica gel pad and a plurality of developing lines, and knots with different numbers or different shapes are arranged on the developing lines with the same shape; and each developing line is fixedly arranged inside or on the surface of the silica gel pad. The device is simple in structure, low in production and manufacturing cost and convenient to operate; by utilizing the characteristic that the developing line can develop in both the molybdenum target and the ultrasonic detection, the developing line can be used for accurately calibrating the focus position detected by the molybdenum target, and the focus position calibrated in the molybdenum target detection can be directly subjected to ultrasonic detection in the ultrasonic detection, so that accurate positioning is provided for further real-time ultrasonic needle biopsy; and the coincidence rate of ultrasound and molybdenum target diagnosis is greatly improved.

The invention relates to the technical field of medical instruments, in particular to an aspiration biopsy needle for tumor tissue, a guide frame comprises a guide disc, U-shaped side guide plates are fixedly connected to the outer wall of the guide disc in an annular array mode, and columnar vertical connecting rods are fixedly connected to the bottom of the guide disc in an annular array mode; by arranging the guide frame and the positioning piece, precise positioning and stable fixing of the tumor tissue needle biopsy needle are achieved, through cooperation of the guide frame and the vacuum adsorption block, the whole device can be quickly and firmly positioned at the part, needing to be punctured, of a patient, a stable foundation is provided for subsequent operation, and the operation efficiency is improved. An electric push rod pushes a rotating block to move downwards to drive a series of linkage structures, so that a clamping block can be flexibly adjusted and accurately fixed according to the position of a puncture needle sliding tube, it is ensured that the puncture needle cannot deviate in the insertion process, and the puncture accuracy and success rate are greatly improved; and extra pain and risk brought to a patient due to inaccurate puncture are effectively reduced.

The invention provides a basilar membrane lesion analysis method and device for a renal needle biopsy transmission electron microscope image and a readable storage medium, and provides a new method based on RADS-Net, and end-to-end automation from segmentation to thickness measurement is realized in combination with Transform and CNN. Comprising the steps of data preprocessing, segmentation, segmentation result optimization and key area screening, thickness calculation, data storage, result output and the like, and detailed elaboration is conducted on specific methods and algorithms of all the steps. The method can effectively improve the analysis efficiency, the segmentation accuracy and the reliability of pathological diagnosis, and has a wide application prospect.

The present application provides a magnetic multi-needle biopsy capsule robot and its control method. The capsule robot includes a capsule shell, each end of the capsule shell is provided with an end perforation, a side perforation is provided on one side of the middle portion, and the interior of the capsule shell is divided into a left chamber, a middle chamber, and a right chamber; the middle chamber is provided with: a first biopsy needle; a first permanent magnet, the first permanent magnet is configured to drive the first biopsy needle to extend from the side perforation under the drive of an external magnetic field; a reset mechanism is configured to drive the first biopsy needle to reset; the left chamber and the right chamber are both provided with: a second biopsy needle; a second permanent magnet, the second permanent magnet is configured to drive the second biopsy needle to rotate and extend from the adjacent end perforation under the drive of an external rotating magnetic field; a spiral structure is configured to achieve the movement of the second permanent magnet along its axis when the second permanent magnet rotates about its central axis. The present application can obtain tissue samples from multiple locations in a single examination, thereby improving the comprehensiveness of the biopsy and the accuracy of the diagnosis.

An inner core is telescopically arranged in a needle tube, one end of the needle tube is concentrically fixed with a sleeve through a Luer taper, a needle head is arranged at the other end of the needle tube, a boosting tube is sleeved outside the rear section of the needle tube, a sheath tube is sleeved outside the front section of the needle tube, and the needle head extends to the outside of the sheath tube. The sheath tube is arranged at the front end of the core rod through the end socket fixing seat, the front section of the core rod is sleeved with an adjusting cylinder in a sliding mode, the rear section of the core rod is sleeved with the sleeve in a sliding mode, an adjusting ring is arranged between the adjusting cylinder and the sleeve, a first adjusting screw is arranged between the adjusting ring and the core rod, and a second adjusting screw is arranged on the side portion of the adjusting cylinder. The ultrasonic needle biopsy needle is convenient to use, wider in applicability and capable of effectively improving the sampling effect.

The utility model relates to the technical field of needle biopsy auxiliary tools, in particular to a high-comfort-degree needle biopsy body position fixing suit which comprises a supporting plate, an anti-skid pad is installed on the top of the supporting plate, a headrest block is arranged on one side of the anti-skid pad, a breathing opening is formed in the surface of the headrest block, upper arm cuffs are arranged on the two sides of the anti-skid pad, and a lower arm cuff is arranged on the other side of the anti-skid pad. The upper arm cuffs are connected and fixed through a binding band, the upper arm cuffs are of a cylindrical structure, and an elastic band is installed at an opening of the upper arm cuffs. According to the high-comfort-degree needle biopsy body position fixing set, the non-slip mat is installed at the top of the supporting plate, a soft and stable supporting surface is provided, compression of the hard supporting plate on the skin of a patient is reduced, and pressing pain or skin injury is effectively prevented. The 10-degree inclined design of the headrest block conforms to the human engineering principle, provides good support for the neck of the patient, and relieves neck discomfort. Due to the design of the cylindrical structure and the elastic band of the upper arm cuff, the arm of the patient can be firmly fixed, blood circulation of the arm is guaranteed, and discomfort is reduced.

The invention relates to the technical field of ultrasonic guidance, and particularly discloses an ultrasonic intervention device for assisting needle biopsy, which comprises an ultrasonic probe, and a puncture frame is arranged on the outer surface of one side of the ultrasonic probe; the number of the transverse supports is two, the number of the longitudinal supports is two, the transverse supports and the longitudinal supports correspond to each other in a pairwise mode, the ultrasonic probes are fixed in the transverse supports and the longitudinal supports, the ultrasonic probes of different sizes can be fixed, and the universality of the puncture support composed of the transverse supports and the longitudinal supports is improved; the transverse support uses the connecting plate as a center and controls the two longitudinal supports at the same time, and the two longitudinal supports drive the two longitudinal supports to synchronously move towards the connecting plate or synchronously move away from the connecting plate under the action of the toothed plate and the rotating gear during adjustment, so that it is guaranteed that the puncture frame is always located in the center of the connecting plate; the rotating gear and the telescopic block are connected through the coil spring, the elastic force generated by the coil spring can be changed by rotating the telescopic block, and the fixing strength of the ultrasonic probe is increased within the elastic limit of the coil spring.

The invention provides a magnetic multi-needle biopsy capsule robot and a control method thereof. The capsule robot comprises a capsule shell, end penetrating holes are formed in the two ends of the capsule shell, a side penetrating hole is formed in one side of the middle of the capsule shell, and the interior of the capsule shell is divided into a left chamber, a middle chamber and a right chamber; a first biopsy needle and a second biopsy needle are arranged in the middle chamber; the first permanent magnet is configured to drive the first biopsy needle to extend out of the side through hole under the driving of an external magnetic field; the resetting mechanism is configured to drive the first biopsy needle to reset; a second biopsy needle is arranged in each of the left chamber and the right chamber; the second permanent magnet is configured to drive the second biopsy needle to rotationally extend out of the adjacent end penetrating hole under the driving of an external rotating magnetic field; the spiral structure is configured to enable the second permanent magnet to move along the axis when the second permanent magnet rotates around the central axis of the spiral structure. According to the invention, the needle can be withdrawn from a plurality of parts in a single examination to obtain tissue samples, so that the comprehensiveness of biopsy and the accuracy of diagnosis are improved.

The present application relates to the technical field of needle sampling device, and particularly relates to an ultrasound-guided puncture needle sampling device, which comprises a needle tube, a sliding cavity is formed in the needle tube, a sampling cavity is formed in the outer wall of the distal end of the needle tube and communicates with the sliding cavity, and the sampling cavity is used for allowing the tissue to be sampled to enter after puncture positioning; a sampling assembly comprises a cutting head, a piston plate, an inner sliding rod and an outer sliding sleeve, the cutting head is sealingly and slidably arranged in the sliding cavity and can move along the axial direction of the needle tube and rotate around the axis of the needle tube. Through cooperation of the needle tube, the sampling cavity, the cutting head, the piston plate, the inner sliding rod, the outer sliding sleeve and the driving assembly, after one-time puncture positioning is completed under the ultrasound guidance, the tissue to be sampled can first enter the sampling cavity, then the cutting head moves forward and rotates to cut in the sliding cavity, and the cut tissue sample can be sucked into the cutting head through the negative pressure formed by the backward movement of the piston plate, so that the number of repeated puncture sampling is reduced.

A tilted needle biopsy assembly is provided for mounting on an x-ray system. Because the biopsy needle is angled relative to at least one of the detector and the x-ray source, x-ray imaging may be performed during the biopsy procedure without interference by the biopsy device. The angled biopsy needle additionally allows improved access to the axilla and chest wall of the patient. The stereotactic biopsy device of the present invention may be coupled to any x-ray system, whether upright or prone, including but not limited to mammography systems, tomosynthesis systems, and combination mammography / tomosynthesis systems. The system flexibly supports the use of any mode of image capture (i.e., scout, two dimensional mammogram, three-dimensional reconstructed volume) for either or both target visualization and target localization. With such an arrangement, a needle biopsy assembly having improved patient coverage is provided for use with a variety of different x-ray imaging platforms.

The utility model relates to the field of animal disease examination, in particular to a needle biopsy tool for animal disease examination. The existing needle biopsy tool has the problems that the operation is not convenient enough, and the biopsy result is inaccurate due to the shaking of a puncture needle in an animal body. The utility model discloses a needle biopsy tool for animal disease examination. The needle biopsy tool comprises a fixed table and the like, four straight grooves are formed in the fixing table, fixing rods are placed in the four straight grooves of the fixing table, and the lower portions of the four fixing rods are connected with nuts through threads. The medical staff screws the threaded rod, the threaded rod moves to limit the first universal ball, and the first universal ball can limit the guide rod, the puncture needle and the needle tube, so that shaking generated after the puncture needle is inserted into an animal body is reduced, and damage to the biopsy animal is reduced.

A pMUT-guided ultrasound bronchoscope is disclosed. The pMUT-guided ultrasound bronchoscope includes an insertion tube having a proximal section and a distal section. A handle is connected to the proximal section, and a distal tip is connected to the distal section of the insertion tube. The handle includes a working channel inlet port for inserting fluids and biopsy tools into a working channel extending through the insertion tube and exiting near the distal tip. A suction button is configured to control a valve disposed adjacent to the suction port to control suction when the suction port is connected to a suction device.

The coaxial puncture needle comprises a needle core, a needle sheath and a limiter, the needle core is arranged in the needle sheath in a penetrating mode, the limiter is arranged on the needle sheath in a sleeving mode, the depth of the needle sheath puncturing into the skin is limited through the limiter, an adhesive tape is attached to the periphery of the limiter, and the adhesive tape is attached to the periphery of the limiter. The limiter is attached to the skin through the adhesive tape to prevent the needle sheath from being taken away from the skin, the head end of the needle core is sharp, the tail end of the needle core is provided with a needle core buckle, the tail end of the needle sheath is provided with a needle sheath buckle, the needle core is buckled on the needle sheath buckle through the needle core buckle and is connected with the needle sheath, the needle sheath buckle is provided with a lever, and the lever is connected with the needle sheath through the lever. The needle core buckle is bounced by pressing the lever, so that the needle core is bounced out of the needle sheath. Compared with the prior art, the efficiency and safety of ultrasonic real-time guided needle biopsy are improved.

The utility model relates to the technical field of medical apparatuses and instruments, and provides an ablation device which comprises an operating mechanism, a needle feeding mechanism, a needle feeding mechanism and an ablation device. A catheter, the proximal end of which is disposed in the operating support body; the hollow ablation needle is movably arranged in the needle inlet tube, the operation supporting body and the catheter in a penetrating mode, the far end of the hollow ablation needle can stretch out of the catheter or retract into the catheter, an axially-through needle passage is formed in the hollow ablation needle, and the hollow ablation needle can conduct ablation operation and needle biopsy and collect biopsy tissue through the needle passage; the hollow ablation needle is detachably connected with the needle inlet tube through the detachable assembly so that the hollow ablation needle can be separated from the operating mechanism and the catheter, and the ablation device has the ablation treatment function and the biopsy function and is simple in structure and convenient to disassemble and assemble.

The invention discloses a model for needle biopsy practice under ultrasonic guidance. The model comprises a model body and a plurality of target objects. The model body is made of thermoplastic elastomer materials, and the thermoplastic elastomer materials comprise 95.5%-98.5% of SEBS base materials, 1%-4% of castor oil and 0.05%-0.5% of nano graphite powder. The target object is a silica gel bead or a plastic bead, the diameter of the target object is 3-10mm, and the target object is embedded in the model body and is arranged in multiple layers or randomly. The invention further provides a preparation method. The preparation method comprises the steps of preheating, baking, melting, stirring, pouring, target object mounting, curing forming and the like. The model for practice can simulate the needle sticking feeling of real tissue, can leave lasting traces after puncture, has high sound transmission performance, is clear in boundary of a target object under ultrasound, solves the technical problem that an existing model cannot meet the needle sticking feeling, the sound transmission performance and puncture trace retention at the same time, and is suitable for popularization and application. And an ideal practicing tool is provided for a needle biopsy technology under ultrasonic guidance.

An imaging system and biopsy sample holder with a housing, a hollow cavity within the housing, a vacuum port positioned at an end of the housing and connected to the hollow cavity, a groove in the upper surface of the housing positioned between the ends of the housing, and a plurality of holes positioned in the groove and extending into the hollow cavity are provided. The groove is configured to receive a tissue sample or a biopsy needle for placement of a tissue sample in the groove. The tissue sample is held in place by negative pressure created by applying a vacuum source to the vacuum port. The holder can couple with the specimen stage of many different types of imagers and is well-suited for use with slide-free imaging techniques such as Fluorescence Imitating Brightfield Imaging (FIBI).

The invention belongs to the technical field of biomedicine, and relates to a methylation characteristic data detection method and a detection kit. The method comprises the following steps: extracting genome DNA from a tissue sample; performing high-throughput detection on the methylation level of the CpG site in the genome DNA to obtain a detection result; constructing a methylation characteristic analysis model based on the methylation state of the CpG site in the detection result; generating methylation feature data of the tissue sample through the model; the methylation characteristic data is used for detecting a kidney cancer specific DNA methylation marker associated with the abnormal tricarboxylic acid cycle metabolism. Through integration of multi-omics data and strict screening standards, detection of needle biopsy and surgical resection samples is supported, compatibility is high, generation and analysis of methylation data are focused, and disease diagnosis or treatment is avoided.

The utility model discloses a developing type puncture needle suite which comprises a hollow outer needle tube and a solid inner needle rod which are connected with an external biopsy gun device, wherein the solid inner needle rod is positioned on an inner cavity of the hollow outer needle tube; a sampling groove is formed in the end, away from the biopsy gun device, of the solid inner needle rod, and at least one section of inner ultrasonic developing area and at least one section of outer ultrasonic developing area which are used for assisting in recognizing the position where puncture reaches a target area and assisting in confirming the sampling position and the sampling length are arranged on the sampling groove and the hollow outer needle tube respectively. Before the biopsy gun device acts, the projection, located at the central axis position of the hollow outer needle tube, of the outer ultrasonic developing area and the projection, located at the central axis position of the hollow outer needle tube, of the inner ultrasonic developing area coincide. The needle biopsy device has the advantages of being capable of assisting an operator in identifying the position of a target area where puncture arrives and accurately confirming the sampling position and the sampling length so as to improve the needle biopsy precision.