The invention relates to the technical field of production and processing of rubber, particularly a mold-pressed sponge sealing rubber strip. The mold-pressed sponge sealing rubber strip comprises the following raw materials in parts by mass: 100 parts of EPDM (ethylene-propylene-diene monomer) unvulcanized rubber, 55-80 parts of reinforcing agent carbon black HS-45, 55-80 parts of paraffin oil, 5-10 parts of zinc oxide, 1-3 parts of stearic acid, 0.5-1.5 parts of surfactant PEG-4000, 1-4 parts of dispersing agent WB16, 8-12 parts of moisture absorber, 1.1 parts of sulfur powder, 1.1 parts of accelerator ZDBC, 1.1 parts of vulcanizing agent DTDM and 0-15 parts of foaming agent ADC. By using the ultralow-mooney-viscosity unvulcanized rubber and abundant chemical foaming agent, the rubber at the mold-pressed the sealing strip corner part of the sealing strip can be foamed in the mold to become gelatin sponge, so that the vertical bar position and the corner position of the sealing strip have close density of rubber, similar hand feeling and consistent door closing force, thereby enhancing the esthetic quality of the sealing strip, lowering the pollution product quantity to some extent, ensuring the excellent sealing property of the product in the use process, enhancing the hand feeling and lowering the processing cost of the manufacturer.