38 results about "Gelatin sponge" patented technology

The embodiment of the utility model provides a puncture suite, which relates to the field of puncture equipment and comprises a sleeve needle, a solid needle core, a hollow biopsy needle, a pusher and an iodine-containing gelatin sponge rod. The sleeve needle is provided with a positioning channel, and the solid needle core and the hollow biopsy needle can be selectively inserted into the positioning channel; the iodine-containing gelatin sponge rod is used for being inserted into the positioning channel after the solid needle core and the hollow biopsy needle are separated from the sleeve needle; and the pusher is matched with the positioning channel in a sliding manner and is used for pushing the iodine-containing gelatin sponge rod into the puncture channel from the positioning channel. The puncture suite is good in hemostatic effect, high in puncture success rate and high in puncture safety.

The invention discloses a multi-section gelatin sponge filling type puncture channel plugging device and a plugging method thereof.The multi-section gelatin sponge filling type puncture channel plugging device comprises a sleeve which is of a long and thin tubular structure, a cylindrical base is integrally formed at the rear end of the sleeve, a wedge-shaped inlet is formed in the base, and scale marks are arranged on the outer surface of the sleeve; the inner core is formed by sequentially arranging a plurality of sections of independent short columnar medical gelatin sponge units, and the inner core is accommodated in the front section of the cannula; the diameter of the pushing rod is matched with the inner diameter of the sleeve, the pushing rod is inserted into the sleeve, and an expanded handheld part is arranged at the rear end of the pushing rod; according to the scheme, the puncture channel can be safely, conveniently and efficiently blocked after the percutaneous intervention puncture channel is established, a small amount of bleeding of the puncture channel is effectively treated, and the risks of secondary bleeding and massive bleeding are reduced or eradicated, so that the related operation safety is improved, and the occurrence rate of related adverse events is reduced.

The application discloses a method for inducing NK cells based on a porous material. The method for inducing NK cells provided by the application is based on a device containing a mesh culture tank and porous gelatin sponge and a culture medium, and can efficiently induce iPSCs-NK. The method solves the problems that current differentiation culture technologies of iPSC-NK rely on feeder layer cells of animal origin, the differentiation efficiency is low, and the purity is insufficient and needs to be further sorted. The method has the potential for large-scale industrial production.

The invention discloses a high-bionic in-vivo immune microenvironment in-vitro skin model and application, and belongs to the technical field of biological medicine. The preparation method of the in-vitro skin model of the high-bionic in-vivo immune microenvironment comprises the following steps: firstly, adding a culture medium into the lower layer of a six-pore plate, then adding a mouse bone marrow cell suspension, then putting the six-pore plate into a Transwell chamber, flatly laying separated mouse skin on an absorptive gelatin sponge, putting the absorptive gelatin sponge into the Transwell chamber, adding the culture medium into the Transwell chamber, and then putting the mouse skin into the transwell chamber to obtain the in-vitro skin model of the high-bionic in-vivo immune microenvironment. Placing the six-hole plate in a cell incubator for culturing to obtain the in-vitro skin model. According to the in-vitro skin-bone marrow cell co-culture system, an immune environment is provided for the in-vitro skin by introducing bone marrow cells, so that the culture environment of the in-vitro skin is more complete, the difficulties that cell components are simple and the immune environment is deficient at present can be solved, and the in-vitro skin-bone marrow cell co-culture system is more in line with the 3R principle and is high in bionic property and low in cost.

The invention belongs to the technical field of medicine, and discloses a medicinal sponge sheet for inhibiting growth of nasal polyp, the medicinal sponge sheet is composed of a medical grade absorptive gelatin sponge base material, triamcinolone acetonide and hydroxypropyl methyl cellulose, the medicinal sponge sheet adopts the medical gelatin base material with the porosity of 95% and the water absorption expansion rate of less than or equal to 30%, the size is 60mm * 20mm * 5mm, each sheet loads 60mg of triamcinolone acetonide, and the hydroxypropyl methyl cellulose is added into the medicinal sponge sheet. And 10% of hydroxypropyl methyl cellulose with the molecular weight of 35000 Da and the viscosity of 700 mPa.s is supplemented to construct a slow release system. Efficient and safe treatment of chronic nasosinusitis with nasal polyp is achieved through multi-dimensional innovative design, the three-dimensional interpenetrating pore structure of the medical gelatin base material provides an ideal carrier for drug release, 60%-70% of triamcinolone acetonide is continuously released within 7 days through the gradient slow release technology, a local high-concentration microenvironment is constructed, and the effect of treating chronic nasosinusitis with nasal polyp is achieved. The device directly acts on the polyp root to block an inflammation cascade reaction; in the formula, hydroxypropyl methyl cellulose is used as a core slow-release carrier.

The utility model relates to a non-contact type multifunctional neurosurgery brain cotton and gelatin sponge transfer tray which comprises an upper tray and a lower tray which can be combined, a hollow cylinder is arranged at one corner of the upper tray, a pin hole column matched with the hollow cylinder through a pin shaft is arranged at one corner of the lower tray, a plurality of partition plates are arranged in the upper tray, and the partition plates are arranged in the lower tray. The upper tray is divided into a plurality of brain cotton storage areas through the partition plates, and a downward-concave circular groove used for storing an aneurysm temporary clip is formed in the lower tray. The utility model designs a double-layer opening and closing type handheld tray which can be opened in a fan-shaped manner when in use. Four kinds of brain cotton of different sizes and models can be placed on the first layer, and meanwhile brain cotton threads can be stretched and cannot be wound mutually; gelatin sponges with different sizes and models can be placed on the second layer, and an aneurysm temporary clip can be placed on the circular sunken part. When a doctor uses the device, a nurse can deliver the brain cotton and the gelatin sponge at the same time, delivery time is saved, and the device is of great significance in dealing with cerebral hemorrhage in an emergency.

The present application relates to the technical field of biology, and particularly relates to an anti-oxidation gelatin sponge and a preparation method thereof. The preparation method comprises the following steps: preparing a lipid nanoparticle containing three nucleic acids of Oct4, Sox2 and Klf4; grafting phenylboronic acid to a gelatin skeleton to obtain a phenylboronic acid gelatin; dissolving the phenylboronic acid gelatin in a lipid nanoparticle solution to form a mixed solution, then adding a tannic acid solution and a hyaluronic acid solution into the mixed solution in sequence to obtain the anti-oxidation gelatin sponge. The anti-oxidation gelatin sponge can be directly implanted or injected into a high fracture site (such as a vertebral body or a femoral neck) of an osteoporosis patient, and can achieve the purposes of treating osteoporosis and preventing first or secondary fracture by long-term regulation of local bone metabolism, reduction of bone resorption and increase of bone density.

The application relates to the technical field of biological medicines, and particularly discloses a gelatin embolization particle and a preparation method and application thereof. The preparation method of the gelatin embolization particle comprises the following steps: taking gelatin as raw material, and performing the following steps of dissolving, foaming, freeze-drying, heat crosslinking, crushing and screening, and sterilization; the foaming step is as follows: nitrogen is introduced into a gelatin aqueous solution with a concentration of 20-100 g / L under a liquid surface, foaming is performed at a rotating speed of 2500-3500 rpm, until no obvious liquid is present at the bottom of a container, and the foaming volume is 1-10 times the original liquid volume; the heat crosslinking step comprises the following steps: the gelatin sponge body is vacuum dried at 60-90 DEG C for 20-30 min, and then vacuum dried at 110-130 DEG C for 10-36 h, and the gelatin embolization particle is obtained. The gelatin embolization particle obtained by the preparation method has high porosity, appropriate water absorption, good in-vitro degradation, excellent suspension performance and catheter passing performance.

The invention relates to the field of animal models, in particular to a method for constructing a chronic tympanic membrane perforation rat model. The construction method comprises the following steps: under a microscope, perforating a rear quadrant of a tympanic membrane of a unilateral ear of a rat, embedding a gelatin sponge into the perforated part for a period of time, and then removing the gelatin sponge to obtain a chronic tympanic membrane perforated rat model; wherein the gelatin sponge is a gelatin sponge infiltrated with a drug solution, and the drug solution is a dexamethasone solution. According to the construction method of the chronic tympanic membrane perforation rat model, the success rate of modeling can be increased on the basis of reducing the death rate of animals, animal waste caused by drug toxicity and the risk of cancerogenic substance exposure of experimenters are reduced, and the construction method has important significance in tympanic membrane perforation research.

The utility model discloses a percutaneous bile duct puncture channel plugging device, and relates to the technical field of medical instruments. The device comprises a puncture tube, a sheath tube is arranged in the puncture tube, an air bag is arranged in the sheath tube, and a protective layer is arranged on the surface of the air bag. The blocking assembly is arranged on the surface of the puncture tube, and the blocking assembly comprises a supporting tube. By arranging the air bag, the air bag can be moved into the puncture channel through the puncture tube after puncture treatment is finished, the air bag is communicated with external inflation equipment through the air inlet tube, and the air bag can be inflated and expanded to support a protective layer compressed gelatin sponge for plugging and enable the gelatin sponge to be attached to the tube wall, so that the rapid plugging effect is achieved; through the arrangement of the blocking assembly, blocking and shielding can be conducted on the external wound position of a patient through the first blocking pad and the second blocking pad in the puncture treatment process, bacteria are prevented from entering, and the protection effect is achieved.

A hemostatic material with near-infrared light-controlled shape memory properties, its preparation method, and its application. Due to the shape memory effect, the sponge's shape can be restored to 90% within 25 seconds. By switching the near-infrared light source on and off, the sponge's expansion can be controlled and adjusted. The sponge's hemostatic ability has been verified in vitro and in vivo. As expected, compared with commercial medical gelatin sponges with insufficient expansion capacity and commercial medical PVA sponges with excessive expansion capacity, the PDA-TPI-PU shape memory sponge can quickly and effectively control bleeding under near-infrared light irradiation, showing potential application prospects as a hemostatic material. With excellent mechanical properties, blood compatibility, cytocompatibility, and photothermal conversion performance, the PDA-TPI-PU sponge provides a new approach to using light-controlled shape memory materials as coagulation materials for treating incompressible bleeding.

The invention provides a coaxial puncture needle supporting advanced introduction of hemostatic gelatin sponge. The coaxial puncture needle comprises a needle tube assembly, a needle rod assembly and an introduction device, the needle tube assembly comprises an outer needle tube, an outer needle seat and a Luer interface; the outer needle tube is connected with the outer needle seat, the outer needle seat is connected with the Luer interface, and the Luer interface is connected with the leading-in device; a sponge channel is formed in the guide-in device, the sponge channel is communicated with the outer needle tube, and hemostatic gelatin sponge is stuffed into the sponge channel; the needle rod assembly comprises a flat-end inner needle, a pointed-end inner needle and an inner needle seat; and the flat-head inner needle penetrates into the outer needle tube through the sponge channel. The guide-in device has the beneficial effects that the guide-in device is adopted, the gelatin sponge is stuffed into the guide-in device in advance, and the guide-in device is immediately connected to the needle tube after the puncture needle is pulled out, so that the guide-in action of the hemostatic gelatin sponge is faster, the guide-in position is more accurate, and the guide-in process is smoother.

The embodiment of the utility model relates to a gelatin sponge slicer, and belongs to the technical field of medical instruments. The gelatin sponge slicer comprises a left leaf and a right leaf, the left leaf and the right leaf are connected in a folded mode so that the left leaf and the right leaf can be oppositely opened, the left leaf and the right leaf are each formed by stacking a plurality of separation blades at intervals, at least one side edge of each separation blade is a scattered edge, and gelatin sponge grooves are formed in the opposite faces of the left leaf and the right leaf. The gelatin sponge groove is used for placing gelatin sponge; the device further comprises a cutting tool. According to the gelatin sponge slicer provided by the embodiment of the invention, the effect of efficiently and safely preparing gelatin sponge sheets is achieved.

The invention discloses a tissue engineering vascular smooth muscle remodeling method based on a conducting polymer and application thereof. The invention finds that the conductive polymer plays a role in promoting the migration of vascular smooth muscle cells and guiding the functional remodeling of the vascular smooth muscle cells. According to the method, a conducting polymer synthesized by biological enzyme is stably modified on a tissue engineering blood vessel in three modes of direct soaking, click chemical grafting or gelatin sponge stent loading. The conductive modified intravascular stent can reconstruct an electrophysiological microenvironment similar to a natural blood vessel, can significantly guide smooth muscle cells to orderly migrate and arrange along the circumferential direction of the blood vessel, and promotes the smooth muscle cells to be transformed to contraction phenotypes expressing markers such as alpha-SMA, SM22alpha, CNN1 and the like, so that a smooth muscle layer close to an autologous blood vessel is structurally and functionally reconstructed. According to the invention, the bottleneck of insufficient functional remodeling of the tissue engineering vascular smooth muscle layer in the prior art is broken through, and a new strategy is provided for regeneration treatment of cardiovascular diseases.

The utility model discloses a gelatin sponge cutting device, solved two clamps only can be to the both sides of gelatin sponge and carry out the location, and the location effect is not good problem, it includes the base, the top of base is provided with sponge limiting component, and sponge limiting component includes the support plate of fixed mounting in the top of base, the top of support plate is provided with sponge cutting assembly, and the top of support plate isohedral angle is provided with four side portion limiting units, and the top of support plate isohedral angle is provided with four sliding slots, and four sliding slots form cross shape, and side portion limiting unit includes the limiting plate, and the outer wall of one end of limiting plate and one side limiting plate is close, and the bottom of limiting plate is provided with push adjustment unit, the utility model discloses, in the work, through the square limiting area of formation between the four limiting plates of setting, can to square limiting area carry out length and width adjustment through the movement of relative two limiting plates, and the convenient limiting of different size gelatin sponge.

The hemostatic gauze for hemodialysis comprises a gauze body, and a plurality of restraint straps are arranged on the gauze body. A contact layer, a hemostasis layer, an isolation layer and a fixing layer are sequentially arranged on the gauze body from bottom to top; the contact layer is made of a hydrophilic biocompatible material; thrombin, chitosan microspheres and gelatin sponge are arranged in the hemostatic layer; the isolating layer is made of a polytetrafluoroethylene film, and the fixing layer is made of elastic medical non-woven fabric. According to the multi-layer structural design that the gauze body is sequentially provided with the contact layer, the hemostasis layer, the isolation layer and the fixing layer from bottom to top, and all the layers are clear in function and cooperate with one another; the contact layer is in direct contact with the wound and is responsible for primary blood coagulation promotion and adhesion prevention; the hemostatic layer can stop bleeding efficiently; the isolating layer plays a dual role in blocking outside bacteria and preventing adhesion; the fixing layer ensures that the whole gauze is stably fixed at the wound part; due to the layered structural design, the hemostatic gauze can effectively meet various requirements for hemostasis and follow-up nursing of a hemodialysis puncture part.

The utility model relates to gelatin sponge production technical field, and disclose a kind of feeding device for gelatin sponge production, solve the problem of current raw material mixing time is longer, it includes stirring bucket, the top of stirring bucket is equipped with adjusting mechanism and inclination mechanism, the upper of stirring bucket is equipped with raw material barrel, adjusting mechanism includes two slide bars fixedly in the top of stirring bucket, the outside of two slide bars respectively movably sleeved with rear sliding plate and front sliding plate, rear sliding plate and front sliding plate between fixedly connected with guide column, the outside of guide column movably sleeved with guide plate, raw material barrel is arranged in the top of guide plate, rear sliding plate side close to front sliding plate is rotatably connected with upper screw rod, the end of upper screw rod away from rear sliding plate is fixedly connected with side shaft;The utility model, it is convenient for guide plate to slide along guide column to make raw material barrel move back and forth, to make raw material be conveniently poured evenly in the inside of stirring bucket, shorten mixing time.

The invention relates to a preparation method and application of a neural tissue engineering blood vessel. The preparation method comprises the following steps: preparing neural stem cell / neural precursor cell neural spheres; preparing a gelatin sponge into a hollow cylinder, adding neural spheres, and incubating to prepare a neural gelatin sponge; and penetrating the decellularized artificial blood vessel or other tissue engineering blood vessels into the neurogelatin sponge for incubation and culture to obtain the neurotized tissue engineering blood vessel. The vascular graft with a nerve secretion function is constructed by optimizing preparation and dynamic culture parameters of neural spheres and combining a cooperative processing technology of a gelatin sponge stent and an acellular vascular matrix, and is used for repairing coronary artery, carotid artery and peripheral vascular defects; the method has the advantages that rapid re-endothelialization, innervation and anti-inflammatory microenvironment formation of transplanted blood vessels can be promoted, repair and fusion of the blood vessels can be accelerated, a new neurotization scheme is provided for tissue engineering blood vessels, and a new method is provided for solving the difficult problems of reconstruction and long-term stability of transplanted blood vessels clinically.

The application discloses a composite hemostatic sponge and a preparation method and application thereof. The sponge takes gelatin sponge as a base body, and is coated with a polymer coating formed by copolymerization of acrylic acid-N-succinimidyl ester and a hydrophilic modified monomer on the surface; the hydrophilic modified monomer is selected from one or more of acrylic acid, 4-acryloylmorpholine or dimethylaminoethyl acrylate. The preparation method comprises the following steps: dissolving monomers in a solvent to initiate a copolymerization reaction, precipitating, cleaning and drying the reaction solution to obtain a copolymer, uniformly coating the copolymer on the surface of the gelatin sponge after redissolving the copolymer, and drying. The composite hemostatic sponge can break away from the dependence on the blood coagulation cascade reaction, can still maintain high adhesion strength in a wet and anticoagulation environment, and does not sacrifice the porous blood absorption characteristics of the sponge itself.

The utility model belongs to the technical field of stirring mixing kettle, disclose a kind of stirring mixing kettle for gelatin sponge production, including kettle body, the inner wall of kettle body is fixedly arranged with heater, stirring mechanism is arranged in kettle body, still fixedly arranged with connecting barrel and hot air blower on the kettle body, and the inner top of kettle body is communicated with one end of hot air blower, and the other end of hot air blower is communicated with connecting barrel;Stirring mechanism is provided with shaft and outer stirring rod, and outer stirring rod is fixedly arranged on the shaft, wherein inner passage is formed in the shaft, and inner through hole is formed in outer stirring rod, and inner through hole is communicated with connecting barrel by inner passage;The utility model, by the cooperation of the hot air blower, shaft and outer stirring rod, the hot air flow generated by hot air blower can play the role of auxiliary heating for the dissolution of gelatin, and the hot air flow can also play the role of impact on gelatin in water, to avoid the laminar flow phenomenon in the stirring process.

A method for preparing a mouse model in which drugs are administrated via hepatic artery infusion includes fixing a mouse in a lateral position after being anesthetized, opening an abdominal cavity of the mouse layer by layer, freeing and exposing celiac artery, ligating two branches of the celiac artery except a common hepatic artery by making slipknots thereon by sterile sutures under an animal microscope, puncturing the celiac artery to make an opening by a 34G syringe, fixing a short segment of an L-shaped microcatheter in the sterile sutures, connecting a tail end of a long segment of the L-shaped microcatheter to a 1 ml syringe, injecting the drugs through the L-shaped microcatheter, removing the L-shaped microcatheter, pressing the opening of the celiac artery with gelatin sponge for hemostasis, removing all of the sterile sutures after above operations are completed.

Provided is a method for constructing a chronic thromboembolic pulmonary hypertension animal model, comprising: taking 180-200 gram adult healthy male SD rats, allowing the rats to freely take water and food; injecting a soluble gelatin sponge solution into the jugular vein of the rats; after 1 day, subcutaneously injecting a Sugen5416 solution; then allowing the rats to freely take water and food for 28 days, to obtain a chronic thromboembolic pulmonary hypertension rat model.

The invention discloses a treatment method for intractable pneumothorax under the guidance of CT (Computed Tomography), which comprises the following steps of: 1, carrying out clinical examination before an operation on an intractable pneumothorax patient needing to be treated through clinical consultation, carrying out consultation judgment according to the clinical examination, and signing an informed consent before the operation; the position and the form of the broncho pleural fistulae are accurately displayed through CT three-dimensional reconstruction, the position of the fistulae is accurately punctured through a PTCB needle under local anesthesia, the purpose of plugging the fistulae is achieved by selecting proper plugging materials such as a medical adhesive / iodized oil mixture, a spring ring and gelatin sponge, and the clinical applicability of the intractable pneumothorax plugging operation under CT guidance is high; required CT and plugging materials are conventionally available in primary hospitals; the device is simple in structure, convenient to operate, accurate in plugging and capable of being carried out only under local anesthesia, most patients can tolerate multiple operations, minimally invasive, safe, efficient and instant in effect, has very important diagnosis and treatment significance on treatment of most refractory pneumothorax, and is worthy of clinical application and popularization.

The utility model relates to the technical field of cutting devices, and discloses a gelatin sponge cutting device which solves the problems that an existing gelatin sponge cutting device is low in cutting speed, cannot rapidly and continuously cut a large number of gelatin sponges and reduces the cutting efficiency. A mounting frame is fixedly mounted in the middle of the top of the bottom plate, supporting plates are fixedly mounted on the two sides of the top of the bottom plate, a connecting frame is fixedly mounted on one side of the mounting frame, a driving motor is fixedly mounted on one side of the connecting frame, and conveying belts are fixedly mounted on the tops of the two supporting plates. Two supporting legs are fixedly mounted at one ends of the bottoms of the two conveying belts, two cutting knives are symmetrically arranged on the upper portion and the lower portion in the mounting frame, a transmission assembly is arranged at the output end of the driving motor, and the transmission assembly is in transmission connection with the two cutting knives; the gelatin sponge cutting device is high in cutting speed and capable of rapidly and continuously cutting a large number of gelatin sponges, and the cutting efficiency is improved.

The utility model relates to the field of gelatin sponge cutting, in particular to a gelatin sponge cutter. The gelatin sponge cutter comprises a shell, the shell is in a cuboid shape, an opening is formed in one side of the shell, a sealing cover is fixed to the opening, and a handle is arranged at the upper end of the shell; the multiple cutting assemblies are movably installed at the lower end of the shell, each cutting assembly comprises a blade, and a rectangular cutting space is formed among the multiple blades; and the adjusting piece is installed in the shell and is further in transmission connection with the cutting assembly. According to the gelatin sponge cutter provided by the utility model, the plurality of blades are distributed in the shape of the Chinese character'kou ', so that the gelatin sponge can be cut by utilizing the blades, and the cut finished product gelatin sponge is uniform in size and meets the use requirements; and meanwhile, the positions of the cutting assemblies can be changed through the adjusting pieces so that different blades can be replaced, and therefore targeted adjustment can be conducted according to the requirements of the sizes of products.

The present invention relates to the field of material technology, and in particular to a gelatin sponge microsphere product and a preparation method thereof. The present invention dissolves gelatin in deionized water to obtain a dispersed phase solution; mixes vegetable oil and a surfactant to obtain a continuous phase solution; mixes vegetable oil and a surfactant to obtain a receiving phase solution; injects the dispersed phase solution and the continuous phase solution into a microfluidic device respectively to obtain gelatin droplets; introduces the gelatin droplets into the receiving phase solution, cools, and solidifies to obtain a crude product; adds a first cross-linking solution to the crude product for preliminary cross-linking and fixation, removes the upper solution, and then adds a second cross-linking solution for further cross-linking and fixation to obtain a semi-finished microsphere product; removes the upper solution from the semi-finished microsphere product and washes it. The present invention uses a cross-linking solution containing alcohol to cross-link the microspheres, so that the cross-linking agent and the microspheres quickly contact and cross-link; it is conducive to the preparation of small-sized droplets, and can also maintain the droplet morphology, so that the surface of the cross-linked microspheres is smooth and wrinkle-free.

The brain cotton piece placing rack comprises a back plate and a liquid storage tank which is arranged at the lower end of the back plate, one end of the liquid storage tank is provided with an opening, the back plate is used for placing gelatin sponge, and the working face of a brain cotton piece is a smooth face. Due to the fact that the working face of the back plate is arranged to be the smooth face, no shielding structure exists in the area, where the gelatin sponge and the brain cotton piece are placed, of the back plate, no shielding is caused to the gelatin sponge and the brain cotton piece placed on the back plate, and meanwhile no shielding or barrier is caused to taking operation of an operator. The gelatin sponge and the brain cotton piece can be conveniently and accurately taken and used by an operator in the microsurgery operation, and the efficiency of the surgery operation is improved.

The invention relates to the technical field of external application medicines, and particularly discloses a breathable external application membrane and a preparation method thereof. Ethyl butyrate and water are prepared into an oil-in-water type micro-transparent emulsion, and then the oil-in-water type micro-transparent emulsion is mixed with a medicine solution, so that the solubility and the storage stability of the medicine are improved; the methacrylic acid gelatin emulsion has viscidity, so that the drug-loaded gelatin sponge and the breathable fiber mesh film can be bonded, and the bonding force of the drug-loaded gelatin sponge and the breathable fiber mesh film is improved; hydrogel with specific components is prepared into a breathable fiber net film matrix by adopting a 3D printing technology, so that survival and proliferation of cells are facilitated, and wound healing is accelerated; the methacrylic acid gelatin has good heat sensitivity and photo-crosslinking capability, so that the interaction and migration between cells are promoted, the metabolic capability of the medicine is improved, and the absorption of the medicine is promoted; the calcium chloride can reinforce the base body of the breathable fiber net film, so that the breathable fiber net film has certain strength, the viscosity of the outer side of the breathable fiber net film is greatly reduced, and the iodophor can prolong the retention time of the medicine.

This invention relates to the field of neurosurgical technology and discloses a method for preparing a gelatin sponge-brain pad composite material for neurosurgical procedures. The method includes preparing a gelatin sponge subunit: mixing medical-grade gelatin, glutaraldehyde, and deionized water, and preparing a cross-linked medical gelatin sponge using a freeze-drying method, which is then categorized into three sizes: S, M, and L. The method also includes preparing a brain pad subunit: sewing medical-grade absorbent cotton with barium contrast agent, and then hydrophilically treating the brain pad. This method for preparing a gelatin sponge-brain pad composite material for neurosurgical procedures standardizes and integrates the gelatin sponge and brain pad according to the surgical type. Preoperatively, there is no need to separately count the two instruments; postoperatively, the quantity is checked according to the packaging unit. This significantly simplifies the instrument management process, reduces the workload of medical staff, and decreases the error rate in instrument counting. Simultaneously, it can accurately match the component specifications and quantities according to different surgical types—basic, delicate, and emergency—avoiding material waste or insufficient supply.

The utility model discloses a clove oil gelatin sponge implanter which comprises a pushing device and an injection tube, and is characterized in that the pushing device comprises a pushing tube and an isolation blocking head arranged at the front end of the pushing tube, a pushing plate is arranged in the pushing tube, a filling opening is formed in the outer surface of the middle of the pushing tube, and the rear end of the pushing tube is in threaded connection with a limiting stopper; one end of the push plate is fixedly connected with a push rod; the tail end of the push rod is fixedly connected with a push handle; the injection tube is movably connected to the front end of the pushing tube in a sleeved mode, a limiting block is arranged at the tail end of the injection tube, a partition film is arranged outside the limiting block, and dotted line stripes are arranged on the surface of the partition film through a dotted line cutting method. The filling opening is formed in the middle of the pushing pipe, so that the clove oil gelatin sponge is convenient to put in, the graduated scale is arranged on the surface of the pushing pipe, the implanted quantity of the clove oil gelatin sponge is controlled, and the clove oil gelatin sponge is prevented from being in contact with other substances before reaching a hemostasis area through the partition film at the tail end of the injection pipe.