Construction of gelatin sponge cylinder bracket used for repairing nerve injury

Abstract

The invention relates to a construction method of a porous gelatin sponge cylinder bracket material used for repairing nerve injury, in particular to a construction method of a stem cell-containing porous gelatin sponge cylinder bracket and an application thereof. When in use, the porous gelatin sponge cylinder bracket planted with stem cells and noblecellsor thereof / and schwann cells is transplanted to the injury part of complete transaction or hemitransection spinal cord, which can better promote injured nervus centralis regeneration and function reparation. The invention has important significance in strengthening injured neuron protection after spinal cord trauma in biological tissue engineering level, promoting axonal regeneration of injured neuron, improving quality of life of the sick and injured, reducing the heavy burdens of society and families, and promoting socioeconomic development of China.

Description

technical field [0001] The invention relates to a construction method of a porous gelatin sponge cylinder support material for repairing nerve damage, in particular to a construction method of a porous gelatin sponge cylinder support containing stem cells and its application. Background technique [0002] Central nervous system injury, such as severe spinal cord trauma, mainly manifests as paraplegia and quadriplegia, and there is no effective treatment method at present. It is traditionally believed that it is difficult to regenerate the central nervous system after injury. It is now believed that the main reason for the difficulty in central nervous regeneration is that there are chemical factors that inhibit nerve regeneration in their microenvironment, and at the same time, they lack neurotrophic factors that promote nerve regeneration. At present, strategies to promote the repair of spinal cord injuries focus on improving the microenvironment of nerve fiber regeneratio...

AI Technical Summary

Problems solved by technology

Due to the disordered structure and poor mechanical properties of natural material scaffolds, although ideal experimental results have been observed in vitro, it will be difficult to transplant them into the body to guide axon regeneration.

2. The main representative of non-degradable materials is silicone tube. This kind of non-degradable synthetic material has a high infection rate, which is easy to cause chronic inflammation and fibrosis. As time goes by, it will have a tendency to compress the regenerated axons. , requiring reoperation to remove the catheter

However, it does not mediate regenerated axons well across the injured area, especially due to the lack of mechanical strength

Gelatin sponge and collagen sponge have the advantages of gel and can easily carry active substances, but their mechanical strength is not high

The biggest advantage of the catheter is that it has a certain mechanical strength and can mediate the regenerated axons to pass through the catheter itself and reach the other end of the transected spinal cord tissue, that is, to play a bridging role. damage to cells

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