20 results about "Paraplegia" patented technology

Compositions and methods for detecting structural variations (SVs) in target genes or for genetic mapping of movable transposable elements are disclosed, the target genes relating to disease pathologies commonly found in large Mendelian genomics projects, and the movable transposable elements relating to genetic diseases, cancer, and aging. The method comprises: (i) contacting a sample containing genomic DNA with a DNA endonuclease for an effective amount of time to cleave the genomic DNA into fragments, the genomic DNA being uncrosslinked; (ii) subjecting the fragments obtained from step (b) to a DNA ligase to obtain circularized DNA; (iii) subjecting the circularized DNA to reverse PCR amplification containing a reverse primer, wherein the reverse primer is designed to match a expected wild-type sequence near a suspected mutant locus in the gene; and (iv) sequencing the amplified products. Exemplary conditions include Bardet-Biedel syndrome; severe upper and lower limb defects; retinitis pigmentosa; syndromic microcephaly; spastic paraplegia; and atypical hemolytic uremic syndrome.

The invention discloses an application of rapamycin in preparation of a composition for treating a hereditary spastic paraplegia SPG subtype. The rapamycin can obviously improve the motion disorder and pathological injury phenotype of an SPG80 subtype mammal model, improve the lysosome function and promote the autophagy process through mTOR inhibition, provides specific intervention for nerve cell apoptosis and a glial cell abnormal activation mechanism caused by UBAP1 deletion, fills the blank that no effective treatment means exists for the SPG subtype, and has a good application prospect. A theoretical basis is provided for clinical treatment of patients, and a reference is provided for other SPG variations (such as SPG3A).

The utility model discloses a walking aid for lower limbs of paraplegia patients, and particularly relates to the technical field of medical instruments, the walking aid comprises a pair of walking aid supports, the walking aid supports are U-shaped, a first supporting rod and a second supporting rod are arranged between the walking aid supports transversely and longitudinally, a lap joint piece is detachably arranged on the longitudinally arranged first supporting rod, and the lap joint piece is detachably connected with the lap joint piece. The lapping piece is divided into two parts, the paraplegia patient can sit on the lapping piece when the two parts of the lapping piece are in a non-folded state, and walking of the paraplegia patient is not affected when the two parts of the lapping piece are in a folded state. The walking aid designed by the utility model provides enough support, facilitates the combination of work and rest, is easy to use and maintain, and is simple in design and moderate in price.

Compositions and methods for detecting genetic structural variations (SVs) in a gene of interest, involved in disease pathologies commonly found in large Mendelian genomics programs; or for genetic mapping of mobile transposable elements, involved in genetic disease, cancer, and aging are disclosed. The methods include: (i) contacting a sample comprising genomic DNA with a DNA endonuclease for an effective amount of time to cleave the genomic DNA into fragments, the genomic DNA has not been crosslinked, (ii) subjecting the fragments obtained from step (b) to a DNA ligase to obtain circularized DNA, (iii) subjecting the circularized DNA to inverse PCR amplification comprising inverse primers, wherein the inverse primers are designed to align with anticipated wild-type sequences, adjacent to a suspected mutation locus in a gene, and (iv) sequencing the amplified product. Exemplary conditions include Bardet-Biedl syndrome; Severe upper and lower limb defects; Retinitis pigmentosa; Syndromic microcephaly; Spastic paraplegia; and atypical hemolytic uremic syndrome.

The present invention discloses a paraplegic walker, comprising: a waist protection assembly, which is enclosed to form a ring structure and is arranged around the patient's waist; two footrest assemblies, which are spaced apart in the left and right directions and are located below the waist protection assembly, and the footrest assembly has a foot pedal; two knee pad assemblies, each of which is connected to a foot pedal, and the knee pad assembly is used to fix the patient's knee; and two support assemblies, the lower ends of the two support assemblies are connected to the two foot pedals in a one-to-one correspondence, and the upper ends of the support assemblies are movably connected to the waist protection assembly so as to be able to swing back and forth relative to the waist protection assembly. The technical solution of the present invention can effectively assist paraplegic patients to walk upright.

The utility model relates to the technical field of medical sickbeds, and particularly discloses a turning-over assisting bed which comprises a bed board frame. The bed body backup plates are arranged on the two sides of the bed board frame; the limiting baffle is mounted at the top end of the bed board frame; through the arrangement of the first rotating rod, the bed board body, the fixing base and the tension spring, when a hemiplegic patient and a paraplegic patient are subjected to turnover rehabilitation training, rotating operation of the bed board can be achieved through the first rotating rod and the second rotating rod which are installed on the bed body backup plate, and in the process, elastic stretching of the tension spring is utilized to enable the patient to turn over. The resistance of the bed board during rotation can be effectively increased, by means of the arrangement, when a patient lies on one side, the limb twisting capacity and resistance resisting capacity of the patient can be fully exercised, then the patient recovers to the prostration state, turning-over training becomes more daily, and by means of the design, the training pertinence is improved, and the training effect of the patient is also improved.

The utility model relates to the technical field of clinical nursing assistive devices, in particular to a foot bottom supporting device for preventing foot drop of paraplegia patients, which comprises an adjusting seat, a supporting plate, an adjusting disc, a rotating rod, a moving block and two groups of moving components. The other end of the rotating rod is rotationally connected with the supporting plate, the moving block is in threaded connection with the rotating rod, each movable assembly comprises a limiting piece, a sliding block, a connecting piece, a telescopic piece and a sole supporting mechanism, the limiting piece is fixedly connected with the supporting plate, the sliding block is in sliding connection with the limiting piece, the connecting piece is fixedly connected with the moving block, and the telescopic piece is fixedly connected with the supporting plate; the sole supporting mechanism is detachably connected with the sliding block, so that the fixed distance between the two feet can be adjusted according to the requirements of the patient, activity training can be provided for the feet of the patient, and the rehabilitation progress of the illness state of the patient is accelerated.

The utility model provides a high paraplegia tracheostomy patient's nurse call unit, including wobble signal sending device, wobble signal receiving alarm device, fixing device and head -wearing device, wobble signal sending device includes wobble sensor and bluetooth signal transmitter, wobble signal sending device is detachably installed on head -wearing device through fixing device, wobble signal receiving alarm device includes buzzer, bluetooth signal receiver, silencing button and rechargeable battery, the utility model need not press and start nurse call unit, can not appear patient and cannot press button and so on the shortcoming, both can reduce the cost of accompanying and nursing, and can provide immediate, effective, portable calling means when the patient accompanying is not in the vicinity, but the patient needs to call for help, reduce the negative emotion of patient because of being neglected. Still can change different head -wearing device according to weather and the demand of patient.

The invention discloses a power exoskeleton device for upper limb rehabilitation assistance, which comprises an arm exoskeleton and an arm exoskeleton fixing bracket, and is characterized in that the arm exoskeleton comprises a shoulder joint rotation driving unit, a shoulder joint rotation center compensation unit, an elbow joint rotation driving unit and a forearm spinning driving unit; the shoulder joint rotation driving unit is composed of three rotation drivers which are mutually orthogonally arranged in space, the elbow joint rotation driving unit comprises a rotation driver, and the forearm self-rotation driving unit drives a forearm fixing support through the rotation driver to achieve forearm self-rotation motion. The introduced shoulder joint rotation center compensation unit can actively or passively compensate the offset of the rotation center, the arm exoskeleton is tightly attached to the human body, the man-machine interaction performance is improved, and the skeleton device can help patients with the upper limb movement function impaired, such as upper limb stroke or paraplegia patients to achieve rehabilitation movement of the upper limbs in the space or plane.

The invention belongs to the technical field of rehabilitation medical auxiliary equipment, and particularly relates to an autonomous walking type paraplegia walking aid. The autonomous walking type paraplegia walking aid comprises a supporting assembly, a lifting assembly and a walking aid assembly. The supporting assembly comprises a bottom frame, a supporting frame, an adjusting frame and a first driving piece, the adjusting frame is in sliding fit with the supporting frame, the first driving piece is matched, the lifting assembly has the lifting motion capacity in space, and the paraplegia patient can be helped to be safely transferred from the wheelchair to the walking aid in a labor-saving mode. In the transferring process, the armpit lifting mode of the supporting rods is adopted, stress is reasonable, and the comfort degree is high. A user can walk autonomously through the walking assisting assembly, extra energy is not needed, economical efficiency is better, application and popularization are easy, and convenience is provided for life of paraplegia patients.

The utility model provides a lower limb paraplegia rehabilitation exercise device, and relates to the technical field of rehabilitation exercise devices, the lower limb paraplegia rehabilitation exercise device comprises a walker, the surface of the walker is fixedly connected with a cushion, the four corners of the bottom of the walker are provided with wheels, the two sides of the surface of the walker are respectively and fixedly connected with a holding rod, and the holding rods are fixedly connected with the cushion. A binding belt is fixedly connected to the surface of the holding rod, auxiliary devices are arranged on the two sides of the surface of the walker, each auxiliary device comprises two mounting plates, the two mounting plates are fixedly connected to the two sides of the surface of the walker correspondingly, and rotating discs are rotationally connected to the surfaces of the two mounting plates correspondingly in a penetrating mode; when the walking device is used, the walking device can be more conveniently used by a patient, the patient can be stably and smoothly driven to move and exercise when the patient is exhausted, the using effect and functionality of the walking device are improved, and therefore the walking device can better assist the patient in exercising and rehabilitation.

The invention discloses a waist paraplegia walking corrector which comprises a crotch torsional pendulum mechanism and two sets of leg fixing mechanisms arranged on the two sides of the crotch torsional pendulum mechanism respectively, a crotch torsional pendulum assembly comprises a torsional pendulum connector, swing rods, a connecting rod and a fixing assembly, and the two sets of swing rods are oppositely arranged left and right; one end of the torsional pendulum connector is fixedly connected to the inner side of the top end of the swing rod on the left side, the other end of the torsional pendulum connector is rotationally connected to the inner side of the top end of the swing rod on the right side, and the connecting rod is detachably connected to the outer side wall of the swing rod through the fixing assembly. The leg fixing mechanism comprises thigh side supporting rods, shank side supporting rods, a knee connecting and adjusting mechanism, an upper hoop part and a lower hoop part, the thigh side supporting rods comprise two sets of thigh side supporting rods which are oppositely arranged left and right, and the thigh side supporting rods located on the inner side are connected to the connecting rod through bolts; the shank side supporting rod is rotationally connected to the bottom end of the thigh side supporting rod through the knee connecting and adjusting assembly.

The invention relates to the technical field of rehabilitation medical equipment, in particular to an exercise device for improving lower limb muscles of a spastic paraplegia patient, the exercise device comprises a moving bed, an angle adjusting set, a base, a threaded positioning plate and a lifting frame, the angle adjusting set is installed on the rear portion of the moving bed, and the angle adjusting set comprises the base abutting against the rear top face of the moving bed; the lower part of the threaded positioning plate is propped against the rear bottom surface of the moving bed. Through an angle adjusting set composed of the base, the threaded positioning plate and the adjusting screw rod, the device can be flexibly installed on a hospital bed, the height of the lifting frame is adjusted according to the rehabilitation stage of a patient and personal requirements, the application range can be widened, and cost can be reduced; meanwhile, the motion amplitude and speed of the swing plate can be controlled by adjusting the threaded rod so as to be suitable for a patient in the initial rehabilitation stage or with weak muscle strength, use safety is ensured, different rehabilitation requirements are met, and then safety and applicability are improved.

A method of treating a patient in need thereof includes administering a therapeutically effective amount of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEH) to serve or function as a nerve growth factor (NGF) activity promoter, preferably to treat and / or prevent a neurodegenerative disease, such as PolyQ disease, Parkinson's disease, Parkinson's syndrome, spinocerebellar degeneration, spastic paraplegia, amyotrophic lateral sclerosis, Alzheimer's disease, dementia with Lewy bodies or corticobasal degeneration.

The present invention relates to a stent comprising a proximal segment, an intermediate segment, and a distal segment, wherein the intermediate segment is connected between the proximal segment and the distal segment, and the stent comprises a support member and a coating, wherein the support member is disposed on the surface of the coating, and in any cross-section perpendicular to the length direction of the stent, the coating is at least partially not disposed on the circumference of the intermediate segment. In the stent of the present invention, the cross-section of the intermediate segment is arc-shaped, and the second coating of the intermediate segment is located on one of the greater curvature side and the lesser curvature side, thereby reducing the overall volume of the stent while avoiding covering the intercostal arteries, thereby effectively reducing the risk of paraplegia.

The invention relates to the field of medical rehabilitation training equipment, in particular to a walking aid for paraplegia and hemiplegia patients, which comprises a lower chassis, an upper support frame connected to the top of the lower chassis and trundles connected to the bottom of the lower chassis, and further comprises a balance component, a walking component and a walking component, one end of the brake assembly is connected to the upper supporting frame, the other end of the brake assembly is connected to the lower chassis, and the brake assembly is located on the front side of the balance assembly; and the waist support assembly is rotationally connected with the balance assembly. The armpit supporting assembly and the control assembly are arranged on the upper supporting frame; and the traction assembly is connected between the upper support frame and the lower chassis. Through mutual cooperation of the balance assembly, the brake assembly, the waist support assembly, the control assembly and the traction assembly, the technical effects of supporting, weight reducing, walking assisting and balance maintaining in the walking process of a paraplegia and hemiplegia patient can be achieved, and the technical problem that in the prior art, a walking aid is prone to unbalance and toppling is solved.

The embodiment of the invention discloses a rehabilitation training system for motor function reconstruction of a spinal cord injury paraplegia patient. A specific implementation mode of the system comprises a bedside lower limb passive training system, a lower limb function reconstruction and intensive training system, a server and a doctor mobile terminal, wherein the server is configured to control the bedside lower limb passive training equipment to assist in performing at least one of the following training at a preset frequency: passive joint training, mind-driven auxiliary exercise training and standing-bed training; the bedside lower limb passive training equipment is configured to execute the following steps: generating training stage conversion test information; the server is further configured to generate second training control information for the lower limb function reconstruction and intensive training system to perform at least one motion function reconstruction training under closed-loop spinal cord stimulation gait adjustment. According to the embodiment, the risk of secondary injury caused in the motion function reconstruction training process is improved.

The present invention relates to an implantable selective spinal nerve root stimulation system, which comprises: a stimulator, which is used to generate an electrical stimulation signal with a frequency, pulse width and intensity, at least one stimulation electrode, which has a stimulation contact at the distal end, and these stimulation electrodes extend toward the head end along the direction of the cauda equina nerve, pass through the dura mater sac area in the midline, pass through the skin from the inside to the outside through the interspinous process gap, or are directly connected to the stimulator along a subcutaneous tunnel. The stimulation contacts carried by the stimulation electrodes are elastically fixed to the free dorsal root nerve area in an embracing manner, wherein the resistance from the stimulation contacts to the cerebrospinal fluid is greater than the resistance between the stimulation contacts and the outer membrane of the dorsal root nerve where they are elastically fixed. The present invention can solve the problem that the existing stimulation electrodes, the spinal cord and the dorsal nerve roots have defects such as poor reliability, great influence of the patient's body position, and high power consumption due to the presence of cerebrospinal fluid of different thicknesses, and cannot effectively promote the recovery of lower limb function of paraplegia after high spinal cord injury.

The utility model discloses an anti-bedsore wheelchair cushion, and relates to the technical field of cushions. The seat cushion comprises a seat cushion body provided with an inner cavity, and the seat cushion body is defined by a bottom plate, side plates and a top face. A plurality of elastic supporting blocks are arranged between the bottom plate and the top surface of the cushion body, the tops of the elastic supporting blocks penetrate out of the top surface, the bottoms of the elastic supporting blocks are fixedly connected with the bottom plate, first through holes are formed in the elastic supporting blocks, and second through holes corresponding to the first through holes are formed in the bottom plate; a third through hole communicated with the inner cavity is formed in the side plate, and a valve switch is arranged at the third through hole on the outer side of the side plate; a heating film, a temperature sensor and a pressure sensor are arranged in an inner cavity of the cushion body, and the temperature sensor and the pressure sensor are connected with a display screen arranged on the outer surface of the cushion body. Compared with the prior art, the multifunctional wheelchair can solve the problem that a stroke hemiplegia patient and a spinal cord injury paraplegia patient use a wheelchair for a long time and cannot change the body position frequently, so that bedsores are caused.

The invention discloses an aortic dissection postoperative paraplegia risk control device, and relates to the technical field of medical instruments, the aortic dissection postoperative paraplegia risk control device comprises an insertion tube section, one end of the insertion tube section is connected with a conversion unit, and the outer side wall of the insertion tube section is sleeved with a fixing unit; the conversion unit is respectively communicated with the monitoring unit and the collecting unit, and the conversion unit is electrically connected with the monitoring unit. The aortic dissection postoperative paraplegia risk control device is simple in structure and low in use cost, the economic burden of a patient can be greatly relieved, meanwhile, intervention can be conducted in time when spinal blood supply is abnormal after an aortic dissection operation, paraplegia of the patient is avoided, the survival rate and the survival time of the postoperative patient are guaranteed, and the risk of paraplegia of the patient is reduced. The prognosis life quality of the patient is improved.