8 results about "Paraplegia" patented technology

Compositions and methods for detecting structural variations (SVs) in target genes or for genetic mapping of movable transposable elements are disclosed, the target genes relating to disease pathologies commonly found in large Mendelian genomics projects, and the movable transposable elements relating to genetic diseases, cancer, and aging. The method comprises: (i) contacting a sample containing genomic DNA with a DNA endonuclease for an effective amount of time to cleave the genomic DNA into fragments, the genomic DNA being uncrosslinked; (ii) subjecting the fragments obtained from step (b) to a DNA ligase to obtain circularized DNA; (iii) subjecting the circularized DNA to reverse PCR amplification containing a reverse primer, wherein the reverse primer is designed to match a expected wild-type sequence near a suspected mutant locus in the gene; and (iv) sequencing the amplified products. Exemplary conditions include Bardet-Biedel syndrome; severe upper and lower limb defects; retinitis pigmentosa; syndromic microcephaly; spastic paraplegia; and atypical hemolytic uremic syndrome.

The invention discloses an application of rapamycin in preparation of a composition for treating a hereditary spastic paraplegia SPG subtype. The rapamycin can obviously improve the motion disorder and pathological injury phenotype of an SPG80 subtype mammal model, improve the lysosome function and promote the autophagy process through mTOR inhibition, provides specific intervention for nerve cell apoptosis and a glial cell abnormal activation mechanism caused by UBAP1 deletion, fills the blank that no effective treatment means exists for the SPG subtype, and has a good application prospect. A theoretical basis is provided for clinical treatment of patients, and a reference is provided for other SPG variations (such as SPG3A).

The utility model relates to the technical field of medical sickbeds, and particularly discloses a turning-over assisting bed which comprises a bed board frame. The bed body backup plates are arranged on the two sides of the bed board frame; the limiting baffle is mounted at the top end of the bed board frame; through the arrangement of the first rotating rod, the bed board body, the fixing base and the tension spring, when a hemiplegic patient and a paraplegic patient are subjected to turnover rehabilitation training, rotating operation of the bed board can be achieved through the first rotating rod and the second rotating rod which are installed on the bed body backup plate, and in the process, elastic stretching of the tension spring is utilized to enable the patient to turn over. The resistance of the bed board during rotation can be effectively increased, by means of the arrangement, when a patient lies on one side, the limb twisting capacity and resistance resisting capacity of the patient can be fully exercised, then the patient recovers to the prostration state, turning-over training becomes more daily, and by means of the design, the training pertinence is improved, and the training effect of the patient is also improved.

The utility model provides a high paraplegia tracheostomy patient's nurse call unit, including wobble signal sending device, wobble signal receiving alarm device, fixing device and head -wearing device, wobble signal sending device includes wobble sensor and bluetooth signal transmitter, wobble signal sending device is detachably installed on head -wearing device through fixing device, wobble signal receiving alarm device includes buzzer, bluetooth signal receiver, silencing button and rechargeable battery, the utility model need not press and start nurse call unit, can not appear patient and cannot press button and so on the shortcoming, both can reduce the cost of accompanying and nursing, and can provide immediate, effective, portable calling means when the patient accompanying is not in the vicinity, but the patient needs to call for help, reduce the negative emotion of patient because of being neglected. Still can change different head -wearing device according to weather and the demand of patient.

The invention discloses a power exoskeleton device for upper limb rehabilitation assistance, which comprises an arm exoskeleton and an arm exoskeleton fixing bracket, and is characterized in that the arm exoskeleton comprises a shoulder joint rotation driving unit, a shoulder joint rotation center compensation unit, an elbow joint rotation driving unit and a forearm spinning driving unit; the shoulder joint rotation driving unit is composed of three rotation drivers which are mutually orthogonally arranged in space, the elbow joint rotation driving unit comprises a rotation driver, and the forearm self-rotation driving unit drives a forearm fixing support through the rotation driver to achieve forearm self-rotation motion. The introduced shoulder joint rotation center compensation unit can actively or passively compensate the offset of the rotation center, the arm exoskeleton is tightly attached to the human body, the man-machine interaction performance is improved, and the skeleton device can help patients with the upper limb movement function impaired, such as upper limb stroke or paraplegia patients to achieve rehabilitation movement of the upper limbs in the space or plane.

The invention belongs to the technical field of rehabilitation medical auxiliary equipment, and particularly relates to an autonomous walking type paraplegia walking aid. The autonomous walking type paraplegia walking aid comprises a supporting assembly, a lifting assembly and a walking aid assembly. The supporting assembly comprises a bottom frame, a supporting frame, an adjusting frame and a first driving piece, the adjusting frame is in sliding fit with the supporting frame, the first driving piece is matched, the lifting assembly has the lifting motion capacity in space, and the paraplegia patient can be helped to be safely transferred from the wheelchair to the walking aid in a labor-saving mode. In the transferring process, the armpit lifting mode of the supporting rods is adopted, stress is reasonable, and the comfort degree is high. A user can walk autonomously through the walking assisting assembly, extra energy is not needed, economical efficiency is better, application and popularization are easy, and convenience is provided for life of paraplegia patients.

The invention relates to the field of medical rehabilitation training equipment, in particular to a walking aid for paraplegia and hemiplegia patients, which comprises a lower chassis, an upper support frame connected to the top of the lower chassis and trundles connected to the bottom of the lower chassis, and further comprises a balance component, a walking component and a walking component, one end of the brake assembly is connected to the upper supporting frame, the other end of the brake assembly is connected to the lower chassis, and the brake assembly is located on the front side of the balance assembly; and the waist support assembly is rotationally connected with the balance assembly. The armpit supporting assembly and the control assembly are arranged on the upper supporting frame; and the traction assembly is connected between the upper support frame and the lower chassis. Through mutual cooperation of the balance assembly, the brake assembly, the waist support assembly, the control assembly and the traction assembly, the technical effects of supporting, weight reducing, walking assisting and balance maintaining in the walking process of a paraplegia and hemiplegia patient can be achieved, and the technical problem that in the prior art, a walking aid is prone to unbalance and toppling is solved.

The embodiment of the invention discloses a rehabilitation training system for motor function reconstruction of a spinal cord injury paraplegia patient. A specific implementation mode of the system comprises a bedside lower limb passive training system, a lower limb function reconstruction and intensive training system, a server and a doctor mobile terminal, wherein the server is configured to control the bedside lower limb passive training equipment to assist in performing at least one of the following training at a preset frequency: passive joint training, mind-driven auxiliary exercise training and standing-bed training; the bedside lower limb passive training equipment is configured to execute the following steps: generating training stage conversion test information; the server is further configured to generate second training control information for the lower limb function reconstruction and intensive training system to perform at least one motion function reconstruction training under closed-loop spinal cord stimulation gait adjustment. According to the embodiment, the risk of secondary injury caused in the motion function reconstruction training process is improved.