100 results about "Leprosy" patented technology

Pharmaceutical compositions and single unit dosage forms of thalidomide and pharmaceutically acceptable prodrugs, salts, solvates, hydrates, or clathrates are disclosed. Also disclosed are methods of treating and preventing diseases and conditions such as, but not limited to, leprosy, chronic graft-vs-host disease, rheumatoid arthritis, sarcoidosis, an inflammatory condition, inflammatory bowel disease, and cancer using the novel dosage forms disclosed herein.

The invention provides a bagged external washing ointment for assisting treatment of gynecologic inflammation and itchiness. The ointment is characterized in that the formula comprises the following raw materials according to weight percentage: 15-35 percent of dandelion, 10-25 percent of sophora flavescens ait, 5-25 percent of common cnidium fruit, 5-25 percent of cortex phellodendri, 15-35 percent of honeysuckle and 3-10 percent of calcined alum. The preparation method comprises the following steps of removing foreign impurities, cleaning, drying, grinding, sieving and bagging. The ointment has the effects of clearing away heat and toxic material, diminishing inflammation, treating urinary tract infection, treating toxic heat, curing leprosy and sore, removing erosion and itchiness of vulva, curing trichomonas vaginitis, eliminating pustules, reducing swelling, curing phlegm and persistent pain, relieving itching, curing trauma infection, relieving prickly heat, astringing, stopping bleeding, growing flesh and the like.

The invention discloses a Chinese preparation for treating burn without leaving scars, which is prepared from the following components in part by weight: giant knotweed 190, garden burnet root 160, rhubarb 135, propolis 145, Hemiboea subcapitata C. B. Clarke 85, cactus 90, Jatropha curcas skin 30, twotooth achyranthes root 85, radix pseudo-ginseng 60, Azolla imbricata 55, beautyberry 35, dragon's blood 30, amur corktree bark 30, pagodatree pod 28, cicada shell 15, musk 0.7, borneol 7.5 and 95 percent alcohol for pharmaceutical purposes 4,500. The preparation has the characteristics of stopping blood, constricting, relieving pains and itching, achieving antibacterial effect, quickly healing wounds and avoiding leaving scars and the like. The preparation can treat burn simply and quickly, does not require strict sterilization operation and can be applied after the wound surface is cleaned simply. The preparation can make epithelial tissue and collagen issue of the wound surface grow in proportion, repair the wound surface more completely and obviously reduce pigmentation and scar generation.

The present invention provides novel imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives of Formula (I), and the pharmaceutically acceptable salts thereof

wherein R¹, R^1a, R^1b, R², R⁴, R⁵, R⁶, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

Dapsone and related sulfones are known to have therapeutic activity against leprosy, dermatitis herpetiformis, actinomycotic mycetoma, asthma, malaria, rheumatoid arthritis, Kaposiís sarcoma, pneumocystis carinií (pneumonia), subcorneal pustular dermatosis and cystic acne, in patients in need of such therapy. These sulfones are also known to have therapeutic activity against memory loss in patients in need of such therapy, including patients suffering from Alzheimer's disease and related neurodegenerative disorders. It has now been found that new, modified-release formulations of dapsone and related sulfones may also be used that decrease side effects and increase effectiveness of the drugs. New methods are disclosed utilizing certain formulations of dapsone and related sulfones that improve the therapeutic index of said drugs. Side effects of these drugs are known to those skilled in the art and include, but are not restricted to anorexia, psychosis, agranulocytosis, peripheral neuritis, hemolysis, methemoglobinemia, nausea, vomiting, headache, dizziness, tachycardia, nervousness, insomnia and skin disorders. Modified-release (as defined herein) formulations of dapsone have now been found to avoid some or all of these side effects, and to have more efficacy on potency.

The present invention provides novel 3,4-disubstituted-1H-pyrrolo[2,3-b]pyridine derivatives and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazine derivatives of Formula I, and the pharmaceutically acceptable salts thereof

wherein R¹, R², R³, R⁴ and X are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

The invention discloses a rheumatoid-arthritis-related single-gene single nucleotide polymorphism site and an application thereof. According to the technical scheme disclosed by the invention, the application is an application of substances for detecting polymorphism or genotype of rs1050501 in human genome in preparation of products for screening patients with rheumatoid arthritis, and an application of substances for detecting polymorphism or genotype of rs1050501 in human genome in preparation of products for predicting the illness states of the patients with rheumatoid arthritis. The substances for detecting the polymorphism or genotype of rs1050501 can be combined with other substances (such as other substances for detecting leprosy-related single nucleotide polymorphism or genotype) to prepare the products for screening patients with leprosy or predicting the illness states of the patients with rheumatoid arthritis.

The invention discloses a kit for detecting HLA-B*1301 gene. The kit comprises the following components: 2*PCR Mix, a target gene detection mix, a reference genes detection mix, a positive reference group pMED-B*1301 and deionized water, wherein the gene detection mix comprises 5'-ggtctcacatcatccagagg-3', and a downstream primer 5'ttcctctgcgacgtcgcg-3'; and the reference genes detection mix comprises an upstream primer beta-F:5'- ctgggacgacatggagaaaa-3', and a downstream primer beta-R:5'- aaggaaggctggaagagtgc-3'. As HLA-B*1301 has close relationship with DHS and has the potential to be the biomarker for predicting dapsone allergic syndrome morbidity of Chinese people, by researching and developing the kit to detect the prediction marker HLA-B*1301 of the dapsone allergic syndrome morbidity, the dapsone allergic syndrome morbidity of leprosy patients can be monitored, therefore, the kit has important clinical significance.

The invention relates to a pharmaceutical composite for treating skin itch. The pharmaceutical composite is prepared from the following medicinal raw materials in parts by weight: 15-40 parts of anti-inflammatory and analgesic bolus powder, 65-155 parts of rehmannia, 30-70 parts of astragalus mongholicus, 65-155 parts of rhizoma smilacis glabrae, 30-70 parts of cortex dictamni, 30-70 parts of Chinese angelica, 60-100 parts of Xanthium canadense, 60-100 parts of wild chrysanthemum flower, 15-40 parts of processed agkistrodon, 65-155 parts of caltrop, 60-100 parts of red-rooted salvia, 30-70 parts of red paeony root, 60-100 parts of kuh-seng, 30-70 parts of toasted spina date seed and 20-50 parts of liquorice. The pharmaceutical composite has the functions of clearing away heat and dampness, activating the circulation of blood and removing stasis, repelling wind and cooling blood, eliminating swelling and removing toxins and killing worms and is applicable to skin itch, chronic mange, rash and blister, scrotum wet and itch, wind leprosy and inflammatory skin which are caused by rash and inflammatory skin diseases.

The invention discloses a Chinese patent medicine ointment for external use on skin, which is prepared from the following raw materials in parts by weight: 18-25 parts of rhizoma atractylodis, 10-15 parts of hemp seed, 2.5-4.8 parts of long-noded pit viper, 18-22 parts of black bean, 10-14 parts of radix ophiopogonis, 6-12 parts of plantago asiatica, 10-17 parts of cyrtomium rhizome and 8-17 parts of garlic bulb core. Compared with the existing medicines, the medicine disclosed by the invention relieves the disease symptoms in a short time and realizes a remarkable curative effect; the long-noded pit viper has the functions of dispelling wind, dredging collaterals and stopping spasm and is applied to rheumatism and obstinate arthralgia, numbness and muscular constriction, wry mouth in stroke, hemiplegia, convulsion and spasm, tetanus, leprosy scabies, scrofula and malignant sore; the radix ophiopogonis has the functions of improving immunologic functions and inhibits multiple kinds of bacteria; the garlic bulb core has the functions of sterilization and itching relief; and through the cooperation of multiple medicines, the effects of inhibiting psoriasis relapse, relieving pruritus and increasing the healing speed are realized.

The present invention relates to the use of compounds with a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, for the preparation of a medicament for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to pharmaceutical compositions comprising them in combination with an antibiotic that is activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, to pharmaceutical compositions comprising them and to their use as medicaments, especially medicaments for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.

The invention provides a dapsone-containing gel preparation and a preparation method thereof and belongs to the new technical field of medicines. The effective ingredient of the gel preparation is dapsone which is a sulfone type bacteriostatic agent, and the gel preparation has a sterilization effect when used in a large-dosage manner, has been used for treating leprosy clinically previously and is found that the gel preparation can also be used for treating nodular acne. A penetration enhancer is preferably selected for the gel preparation, so that the gel preparation has a good penetration property and a high deep sterilization function, can clear deep acne, is convenient to use, attractive in appearance and easy to clean and has no irritation to skin.

The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1 or a pharmaceutically acceptable salt, solvate or ester thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, zenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.

The present invention discloses an efficient psoriasis vulgaris treating ointment, which is made from the following raw materials, by weight: 8-15 parts of radix sophorae flavescentis, 15-20 parts of stellera chamaejasme, 8-12 parts of cortex dictamni, 20-25 parts of zaocys dhumnades, 5-10 parts of indigo naturalis, 8-15 parts of lithospermum erythrorhizon, 20-28 parts of coix seed, and 80-150 parts of vaseline. According to the present invention, the drug can be used for the psoriasis vulgaris treating, the recurrence rate is reduced after using the drug of the present invention, the effect is high, and the skin itching and pain is reduced; the radix sophorae flavescentis has effects of heat clearing, dampness eliminating, insect disinfestation and dieresis, and is used for treatment of dysentery caused by heat, hematochezia, jaundice, uroschesis, leukorrhea with reddish discharge, vulvar swelling, vulvar itching, eczema, damp sore, skin itching, scall and leprosy; the zaocys dhumnades has effects of wind-evil dispelling, collateral dredging and convulsion relieving, and is used for treatment of rheumatism obstinate arthralgia, leprosy scall and scrofula ulcer; and the multiple drugs are matched so as to improve the treatment effect.

The invention provides a bagged external washing product for assisting in treating apoplexy, which is characterized in that a formula of the bagged external washing product for assisting in treating apoplexy consists of the following ingredients in proportions: 15-35 percent of castor beans, 5-25 percent of cicada slough, 15-35 percent of folium artemisiae argyi, 10-35 percent of pepper, 10-25 percent of garden balsam stem, and 10-20 percent of mulberry bark. A preparation method of the bagged external washing product comprises the steps of removing impurities, cleaning, drying, grinding and sieving. The external ointment integrates the effects of reducing swelling and drawing out poison, sore and leprosy, treating hemiplegia paralysis, anaudia and trismus, migraine and deafness and swollen tongue, dredging orifices of the head and stagnated fire, removing slight corneal opacity and improving eyesight, treating apoplexia and trismus, fever and coma as well as insanity and phlegm, curing pathogenic qi in heart and abdomen, dispersing heat in heart, regulating qi and invigorating the circulation of blood, relieving pains and tracing poison, treating stagnation of qi and blood, curing pyogenicinfections, removing mephitis, apoplexia and trismus, stopping cholera, and the like, and has auxiliary treating effect on apoplexy.