Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

27 results about "Paralysis" patented technology

Loss of muscle function in one or more muscles.

Systems and / or methods for assessing neuromuscular block status without stimulation

Neuromuscular block characterization techniques are disclosed. A muscle movement measurement device generates, unprompted by impulse stimulation to a subject from an external source, at least one signal representative of muscle movement measurements at at least one location of a body of the subject while the subject is experiencing neuromuscular paralysis caused by biophysiological processes at neuromuscular synapses throughout the body including remote from the at least one location. A processing circuit runs a neuromuscular block analysis module that receives the at least one signal, analyzes the muscle movement measurements embedded in the at least one signal, and determines a degree of neuromuscular blockade associated with the neuromuscular paralysis being experienced by the subject. The processing circuitry further generates, for display via a display device, an indication of the degree of the neuromuscular blockade at each said location on the body.
Owner:BLOCKSYNOP INC

Dog lifting device

This invention discloses a dog lifting device (10) for animals particularly for big breed canine or dogs as a support during medical or surgical procedures but more particularly to a dog lifting device (10) which permits large and heavy dogs to be lifted with relative ease during periods of medical and surgical procedures, temporary or permanent paralysis. The dog lifting device (10) comprises a frame (12), a motored hoist (22) secured to the frame (12), an actuator (24) connected to the motored hoist (22) and a lifting rope (26) operably connected to the actuator (24) with a pulley (26) that translates the horizontal force from the motored hoist (22) to the lifting rope (26) which makes the dog lifting device (10) efficient, safe and easy to use with due regard to animal welfare.
Owner:ELESTWANI MARIAM

HERV-k (HML-2) ENV analog fusion proteins for antigen specific immunotherapy and methods of use

ActiveUS20260035414A1Nervous disorderAntibody mimetics/scaffoldsDiseaseMuscular weakness
The present disclosure provides recombinantly manufactured fusion proteins comprising a HERV-K (HML-2) Env protein fragment or an analog thereof linked to a human Fc fragment. Embodiments include the administration of the fusion proteins to patients having a disease or a disorder with the intention of mitigating and / or reducing the duration of symptoms associated with the condition or disease (for example but not limited to muscular weakness, paralysis and respiratory failure), and / or preventing symptoms associated with the condition or disease, for example, by preventing motor neuron degeneration and cell death in ALS patients associated with the condition or disease. Accordingly, “treatment” generally means both therapeutic treatment and prophylactic or preventative measures. Improvement after treatment may be manifested as a decrease or elimination of such symptoms, e.g., by a decrease or elimination of symptoms associated with ALS, and / or by a decrease in the duration of such symptoms.
Owner:TWILIGHT BIOSCIENCE INC

HERV-k (HML-2) ENV analog fusion proteins for antigen specific immunotherapy and methods of use

PCT designated stageWO2026030596A1Nervous disorderCell receptors/surface-antigens/surface-determinantsDiseaseMuscular weakness
The present disclosure provides recombinantly manufactured fusion proteins comprising a HERV-K (HML-2) Env protein fragment or an analog thereof linked to a human Fc fragment. Embodiments include the administration of the fusion proteins to patients having a disease or a disorder with the intention of mitigating and / or reducing the duration of symptoms associated with the condition or disease (for example but not limited to muscular weakness, paralysis and respiratory failure), and / or preventing symptoms associated with the condition or disease, for example, by preventing motor neuron degeneration and cell death in ALS patients associated with the condition or disease. Accordingly, "treatment" generally means both therapeutic treatment and prophylactic or preventative measures. Improvement after treatment may be manifested as a decrease or elimination of such symptoms, e.g., by a decrease or elimination of symptoms associated with ALS, and / or by a decrease in the duration of such symptoms.
Owner:TWILIGHT BIOSCIENCE INC

Auxiliary rehabilitation device for limb paralysis

The invention discloses an auxiliary rehabilitation device for limb paralysis, which comprises a clamping mechanism used for being clamped on a bed or a chair; the number of the fixing mechanisms is two, the two fixing mechanisms are used for being arranged on limbs in a sleeving mode, each fixing mechanism comprises a fixing ring, an air bag and an air supply assembly, the air bags are arranged along the inner walls of the fixing rings, and the air supply assemblies communicate with the air bags; the clamping mechanism is connected with the two fixing rings through the posture adjusting mechanism, the posture adjusting mechanism is used for adjusting the space positions of the two fixing rings so as to adjust the posture of the limbs, and the gas supply assembly is installed on the posture adjusting mechanism. The rehabilitation training device can be used for upper limb rehabilitation training and lower limb rehabilitation training, a patient can lie or sit, and the rehabilitation training device is suitable for full-paralyzed or semi-paralyzed patients, flexible and convenient to use and high in universality.
Owner:THE SECOND AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIV

System for detecting exercise intention of user and controlling functional electrical stimulation (FES) according to same

The present application relates to a rehabilitation system based on brain-computer interface (BCI) and functional electrical stimulation (FES) technology. Specifically, the present application relates to a system for detecting a user's exercise intention and promoting recovery of lower extremity functions through electrical stimulation according to same, and relates to a rehabilitation and assistance system for impaired persons suffering from paralysis or complete paralysis of the lower extremities. According to the present application, neural signals due to motor imagery of a user are analyzed in real time, and electrical stimulation is applied to a specific muscle group on the basis thereof to improve motor function.
Owner:KOREA INST OF SCI & TECH

Systems for inhibiting heterotopic ossification

ActiveUS12508374B2Surgical needlesAutomatic syringesMuscle tissueNeuromuscular inhibition
Systems for treating a targeted volume of muscle tissue to inhibit heterotopic ossification (HO) employ a delivery device including a reservoir containing a neuromuscular inhibitor and an injector assembly. The injector assembly can include an arrangement of needles and an injector operable to pass the neuromuscular inhibitor from the reservoir through the needles. The injector assembly can be configured to eject predetermined aliquots of a therapeutic dose of the neuromuscular inhibitor. The injector assembly can be shaped to compliment the targeted volume of muscle tissue within a larger volume of muscle tissue. The ejection of the predetermined aliquots can result in a therapeutic distribution of the therapeutic dose of the neuromuscular inhibitor within the targeted volume of muscle tissue that is sufficient to prevent formation of an HO lesion but insufficient to induce paralysis of the larger volume of muscle tissue.
Owner:UNIV OF WASHINGTON

HERV-k (HML-2) ENV analog fusion proteins for antigen specific immunotherapy and methods of use

PendingUS20260035415A1Antibody mimetics/scaffoldsVirus peptidesDiseaseMuscular weakness
The present disclosure provides recombinantly manufactured fusion proteins comprising a HERV-K (HML-2) Env protein fragment or an analog thereof linked to a human Fc fragment. Embodiments include the administration of the fusion proteins to patients having a disease or a disorder with the intention of mitigating and / or reducing the duration of symptoms associated with the condition or disease (for example but not limited to muscular weakness, paralysis and respiratory failure), and / or preventing symptoms associated with the condition or disease, for example, by preventing motor neuron degeneration and cell death in ALS patients associated with the condition or disease. Accordingly, “treatment” generally means both therapeutic treatment and prophylactic or preventative measures. Improvement after treatment may be manifested as a decrease or elimination of such symptoms, e.g., by a decrease or elimination of symptoms associated with ALS, and / or by a decrease in the duration of such symptoms.
Owner:TWILIGHT BIOSCIENCE INC

Gloves with zippers

We provide gloves with a zipper that make it easy to put on and take off five-finger gloves. [Solution] Open zipper 1 attached to the index finger side and zipper 2 attached to the little finger side of the five-finger glove all the way, fully extend the glove, and once the finger pockets are visible, insert your hand and make sure that your fingertips are securely in place, then close zippers 1 and 2. This reduces the time and effort required to put on and take off the gloves, and in particular, when assisting people with disabilities or paralysis, or their caregivers, to put on gloves, it reduces the effort of fumbling around to place each finger into the finger pocket, and allows for quick preparation.
Owner:大貫 圭子

HERV-k (HML-2) ENV analog fusion proteins for antigen specific immunotherapy and methods of use

PCT designated stageWO2026030590A1Nervous disorderAntibody mimetics/scaffoldsDiseaseMuscular weakness
The present disclosure provides recombinantly manufactured fusion proteins comprising a HERV-K (HML-2) Env protein fragment or an analog thereof linked to a human Fc fragment. Embodiments include the administration of the fusion proteins to patients having a disease or a disorder with the intention of mitigating and / or reducing the duration of symptoms associated with the condition or disease (for example but not limited to muscular weakness, paralysis and respiratory failure), and / or preventing symptoms associated with the condition or disease, for example, by preventing motor neuron degeneration and cell death in ALS patients associated with the condition or disease. Accordingly, "treatment" generally means both therapeutic treatment and prophylactic or preventative measures. Improvement after treatment may be manifested as a decrease or elimination of such symptoms, e.g., by a decrease or elimination of symptoms associated with ALS, and / or by a decrease in the duration of such symptoms.
Owner:TWILIGHT BIOSCIENCE INC

Rehabilitation booster for paralysis of upper and lower limbs

The upper and lower limb paralysis rehabilitation booster comprises a base, an upper limb training assembly, a lower limb training assembly and a seat are arranged on the base, an adjusting groove is formed in the base in the length direction, an adjusting screw rod is rotationally connected into the adjusting groove, an adjusting block is in threaded connection with the adjusting screw rod, and the cross section of the adjusting block and the cross section of the adjusting groove are both square. The adjusting block is slidably connected into the adjusting groove, the seat is arranged on the adjusting block, an adjusting motor for driving the adjusting screw to rotate is arranged on the outer surface of the base, the adjusting screw drives the adjusting block to move along the adjusting groove, and the adjusting block moves to drive the seat to be close to or away from the training assembly. Therefore, the distance between the seat and the training assembly can be flexibly adjusted. The rehabilitation training device has the effect of improving the comfort of a patient during rehabilitation training.
Owner:TAICANG JINGQUAN METAL PROUDUCTS CO LTD

Tibetan medicine 56-site agate pill and preparation process thereof

The Tibetan medicine fifty-six agate pill is mainly prepared from fifty-six medicinal materials including zota, pearls, agate, fructus chebulae, semen myristicae, tabasheer and the like, and has the effects of restoring consciousness, inducing resuscitation, easing mental tranquility, clearing and activating the channels and collaterals, enriching blood, tonifying qi, building the body, prolonging life and enhancing the immunity of the organism. The traditional Chinese medicine composition is used for treating red pulse, black pulse and white pulse diseases caused by the longishi disease and three-cause (longishi, red pulse and bacon) imbalance, and cardiovascular and cerebrovascular diseases and nervous system diseases. The traditional Chinese medicine composition is suitable for diseases such as heart disease, Parkinson's disease, Alzheimer's disease, sleep disorder, hypertension, Meniere's syndrome, gastrointestinal diseases, stroke, paralysis, hemiplegia, ankylosing spondylitis, epilepsy, cerebral hemorrhage, cerebral concussion and gradual freezing; and various intractable diseases such as heavy metal detoxification are treated.
Owner:CHENGDU WUHOU GANLU HAIZANG HOSPITAL CO LTD

Auxiliary traction apparatus for orthopedic surgeon

Disclosed in the present invention is an auxiliary traction apparatus for an orthopedic surgeon, relating to the technical field of orthopedics. The auxiliary traction apparatus comprises a bottom plate; an upper end of the bottom plate is rotatably connected to an inclined plate; an upper end of the inclined plate is rotatably connected to a sliding plate; the surface of the sliding plate is provided with a lower fixing ring and an upper fixing ring; a lower end of the sliding plate is connected to a slide plate; the slide plate is slidably connected to the bottom plate; the surface of the slide plate is rotatably connected to an electric push rod. In the present invention, the angles of the inclined plate and the sliding plate are changed by means of the electric push rod, so that the legs of a patient are lifted to help the patient move, thereby avoiding paralysis caused by the legs of the patient not moving for a long time; meanwhile, a connecting column and a spring can prevent the electric push rod from directly acting on the surface of the inclined plate, so that the operation can be stopped when the patient feels pain, thereby protecting the safety of the patient.
Owner:THE FOURTH AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV(GUANGZHOU ZENGCHENG DISTRICT PEOPLES HOSPITAL)

Herbal solution containing Ruta Graveolens and Saxifraga, and method for its preparation

The present disclosure relates to a herbal mouthwash containing Ruta graveolens and Saxifraga, specifically developed for the prevention of neurological diseases such as Parkinson's, Alzheimer's, paralysis, and nerve damage. The process involves preparing the herbal mouthwash by soaking a finely ground mixture of Ruta graveolens and Saxifraga in alcohol. The resulting solution is administered as a mouthwash and used for rinsing and gargling. The invention offers an effective, natural therapeutic alternative for treating neurodegenerative diseases, promoting neuroprotection, and potentially supporting the regeneration of damaged nerve cells.
Owner:SCHILLING JOHANN GEORG

Position restraint device for neurosurgery nursing

The utility model discloses a neurosurgery nursing body position constraining device which comprises a bed board, a supporting frame is arranged at the bottom of the bed board, moving wheels are arranged at the four corners of the bottom of the supporting frame, fixing plates are arranged on the two sides of the end, located at the head, of the bed board, and connecting columns are rotationally connected to the fixing plates. An arm supporting plate is fixedly connected to the top end of the connecting column, two fixing belts are arranged on the arm supporting plate, and a movable seat is slidably connected to the portion, located on the lower half body, of the upper surface of the bed board. By unscrewing the first stud, the first knob can be separated from the bottom of the fixing plate, and the connecting column can be rotated, so that the arm supporting plate can rotate by taking the axis of the connecting column as the circle center, the arm placement of a patient can be adjusted, and the comfort of the patient can be improved; meanwhile, pain and paralysis caused by the fact that the handle of the patient is in the same state for a long time can be avoided.
Owner:JINHUA MUNICIPAL CENT HOSPITAL

clothespins

As we age, our bodies undergo changes, particularly numbness, pain, and paralysis in our hands, fingers, and arms, making it difficult to open standard metal spring clothespins with our fingers. This laundry peg, designed for those with limited strength, including the elderly, disabled, those with mild illnesses or injuries, and even infants, can easily open and close clothespins using their entire hands and fingers to clamp laundry. Instead of using standard metal springs, these clothespins feature a plastic arc section, a mating section, and a clamping section. The two clamping rods are molded as a single unit and fit together at the mating section. The top of the arc section is a spring, and by gripping both sides of the arc with your hands and fingers, you slide the interlocking rod to open and close the clamping section and clamp laundry. This laundry peg features a slip-resistant handle for those who want to hang out their laundry independently despite their limited strength. The top of the arc section is designed to prevent damage to the spring, making it suitable for general use. Since it does not use metal springs, it is easy to recycle and is an SDGs product.
Owner:狩野 三雄

A traditional Chinese medicine compound preparation for treating motor dysfunction of Parkinson's disease

This invention relates to the field of pharmaceutical technology for treating motor dysfunction in Parkinson's disease, and particularly to a traditional Chinese medicine preparation for treating motor dysfunction in Parkinson's disease. The formula consists of Cimicifuga rhizome, processed turtle shell, Angelica sinensis, raw licorice root, ginger-processed Pinellia ternata, Gastrodia elata, and scorpion. This invention uses a traditional Chinese medicine formula to treat motor dysfunction in Parkinson's disease. The medicinal materials comply with national regulations for the management of traditional Chinese medicine materials and have undergone clinical testing. The formula is rationally formulated with high synergistic effects and long-lasting and stable efficacy. Based on the principles of traditional Chinese medicine syndrome differentiation and treatment, this formula addresses the deficiency of both liver and kidney, and the insufficiency of qi and blood, with tremor and paralysis attributed to internal liver wind. It significantly improves motor dysfunction and tremor symptoms in Parkinson's disease. This preparation is highly effective, safe, reliable, and has few side effects. It can also significantly reduce the expression levels of tyrosine hydroxylase in the substantia nigra and striatum. This preparation represents a new approach to treating motor dysfunction in Parkinson's disease and has broad prospects in the field of treating this condition.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY

HERV-k (HML-2) ENV analog fusion proteins for antigen specific immunotherapy and methods of use

PCT designated stageWO2026030592A1Antibody mimetics/scaffoldsViral antigen ingredientsDiseaseMuscular weakness
The present disclosure provides recombinantly manufactured fusion proteins comprising a HERV-K (HML-2) Env protein fragment or an analog thereof linked to a human Fc fragment. Embodiments include the administration of the fusion proteins to patients having a disease or a disorder with the intention of mitigating and / or reducing the duration of symptoms associated with the condition or disease (for example but not limited to muscular weakness, paralysis and respiratory failure), and / or preventing symptoms associated with the condition or disease, for example, by preventing motor neuron degeneration and cell death in ALS patients associated with the condition or disease. Accordingly, "treatment" generally means both therapeutic treatment and prophylactic or preventative measures. Improvement after treatment may be manifested as a decrease or elimination of such symptoms, e.g., by a decrease or elimination of symptoms associated with ALS, and / or by a decrease in the duration of such symptoms.
Owner:TWILIGHT BIOSCIENCE INC

Neuroprosthesis apparatus for stimulating leg movement

A neuroprosthesis apparatus for stimulating leg movement in a user via functional electrical stimulation includes a waistband and a pair of leg attachment members. Each leg attachment member is coupled to and extends downwardly from the waistband. A user wears the apparatus with the waistband extending around the user's body and each leg attachment member attaching to one of the legs of the user. An electrical stimulator comprises a plurality of electrodes that is dispersed along each leg attachment member. The electrodes selectively transmit electrical current through a skin of the user to efferent nerves to induce muscle contractions and enable movement of the legs and feet of a user experiencing paralysis.
Owner:RHABURN JAMANTHA

HERV-k (HML-2) ENV analog fusion proteins for antigen specific immunotherapy and methods of use

PCT designated stageWO2026030597A1Antibody mimetics/scaffoldsViral antigen ingredientsDiseaseMuscular weakness
The present disclosure provides recombinantly manufactured fusion proteins comprising a HERV-K (HML-2) Env protein fragment or an analog thereof linked to a human Fc fragment. Embodiments include the administration of the fusion proteins to patients having a disease or a disorder with the intention of mitigating and / or reducing the duration of symptoms associated with the condition or disease (for example but not limited to muscular weakness, paralysis and respiratory failure), and / or preventing symptoms associated with the condition or disease, for example, by preventing motor neuron degeneration and cell death in ALS patients associated with the condition or disease. Accordingly, "treatment" generally means both therapeutic treatment and prophylactic or preventative measures. Improvement after treatment may be manifested as a decrease or elimination of such symptoms, e.g., by a decrease or elimination of symptoms associated with ALS, and / or by a decrease in the duration of such symptoms.
Owner:TWILIGHT BIOSCIENCE INC

Implantation of deep brain stimulation leads for recovery of motor control and speech

PCT designated stageWO2026036147A1Head electrodesArtificial respirationThalamusBrain deep stimulation
This disclosure provides a method for optimizing surgical placement of stimulation leads within the thalamus to treat a motor disorder in a subject, such as paralysis of the upper-limb and face muscles, which cause speech motor deficits. Also provided are methods for treating motor disorders in a subject.
Owner:UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION

Occlusion apparatus

PCT designated stageWO2026001713A1OcculdersTissue fixingBlood vessel
Disclosed in the present invention is an occlusion apparatus, which comprises a first disc body, a second disc body, a waist portion, and a connecting portion, wherein the first disc body and the second disc body are connected by means of the waist portion; the first disc body is configured to be placed on a first side of a site to be occluded; the second disc body is configured to be placed on a second side of said site; the waist portion penetrates through said site; the connecting portion is disposed on a side of the first disc body and / or the second disc body close to said site, and the connecting portion is configured to be fixedly connected to a peripheral tissue of said site. The present invention can achieve precise occlusion of said site, and can enable the first disc body, the second disc body, and the waist portion to adhere well to the wall of the peripheral tissue of said site. Moreover, the occlusion apparatus can be prevented from falling off, and the use of the occlusion apparatus can prevent excessive occlusion, so that obstruction of the blood flow in a collateral vessel at said site can be prevented, thereby avoiding paralysis.
Owner:SHANGHAI SHAPE MEMORY ALLOY

Buffering and damping axillary crutch

The buffering and damping axillary crutch comprises an axillary supporting part, a handheld part, a supporting pipe part and a supporting foot part which are sequentially arranged from top to bottom, the supporting pipe part comprises an adjusting outer pipe, the supporting foot part comprises an adjusting inner pipe, a damping connector, a spring piece, a damping inner sleeve, a foot pipe and a foot pad, the upper end of the adjusting inner pipe is sleeved with the adjusting outer pipe, and the lower end of the adjusting inner pipe is sleeved with the damping connector. The damping connector is sleeved at the lower end of the adjusting inner pipe, the damping inner sleeve is sleeved in the foot pipe, the foot pad is sleeved at the lower end of the foot pipe, the damping connector is movably sleeved in the damping inner sleeve, the spring piece is arranged in the damping inner sleeve, one end of the spring piece abuts against the damping connector, and the other end of the spring piece abuts against the damping inner sleeve. The buffering and damping axillary crutch has the advantages of being good in use comfort and capable of effectively relieving armpit paralysis and reducing the risk of armpit injury.
Owner:CAREMAX REHABILITATION EQUIP

Optical sensing to detect muscle density in a wearable electrical muscle stimulation apparatus

Described herein are electrical muscle stimulation (EMS) apparatuses (e.g., devices and systems, including suits, controls, etc.). Also described herein are EMS configured to determine one or more indicators of muscle density, and method of using them. Also described herein are EMS apparatuses and methods of using them for treating one or more of: arthritic pain, hypertension, and / or paralysis.
Owner:LF BOLT CORP

High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury

ActiveUS12649062B2Spinal electrodesChiropractic devicesAutonomic functionSexual functioning
A system and methods are disclosed for enabling or improving control of cardiovascular and / or vasomotor autonomic functions in a patient having a neurologically derived paralysis or a nervous system disorder.
Owner:CALIFORNIA INST OF TECH +2