The invention provides an external skeleton assisted rehabilitation therapy system. The system comprises a base plate, a partition plate, a thin-diameter alloy wire, a tail-end execution continuous body mechanism and a driving portion, wherein the tail-end execution continuous body mechanism is composed of a tail end piece, and the driving portion is used for driving the tail-end execution continuous body mechanism to move. The driving portion comprises a transmission mechanism and a driving continuous body mechanism. The driving continuous body mechanism comprises a lower-end installation plate, a thick-diameter alloy wire, an inner-layer partition plate, an outer-layer partition plate and tail-end clamping discs. One end of the thin-diameter alloy wire and one end of the thick-diameter alloy wire are fixed on the same tail-end clamping disc. The other end of the thin-diameter alloy wire is fixed on the tail end piece and can freely slide in the base plate and the partition plate, therefore, the thick-diameter alloy wire is pushed or pulled, and when the driving continuous body mechanism bends, the tail-end execution continuous body mechanism correspondingly bends. According to the external skeleton assisted rehabilitation therapy system, accidental injuries to patients can be prevented, meanwhile, the muscle-bone structures of different users can be self adapted, and the adjustment of hardware due to changing of the users is reduced as far as possible.