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191results about How to "Reduce need" patented technology

Method for bacterial lysis

The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microfluidic devices and methods of manufacture of such microfluidic devices comprising a substrate with at least one channel packed with a polymer monolith embedded with carbon particles, for example carbon nanotubes. The microfluidic devices and methods of the present invention are useful for cell lysis of cells within a biological sample, such as a untreated biological sample comprising microorganisms, such as but not limited to gram positive and gram negative bacteria. In some embodiments, the microfluidic devices of the present invention can also optionally comprise other modules enabling further processing of the biological sample, for example isolation, purification and detection of biomolecules released from the lysed cells, such as but not limited to nucleic acids or proteins or peptides from the lysed cells, providing a complete Lab-on-a-Chip analysis system for biomolecules released from difficult to lyse microorganisms in a single step or process. The microfluidic devices of the present invention can also be adapted and are useful to methods to enrich for microorganisms in a biological sample, for example enrich for a desired type of bacteria within a biological sample. The microfluidic devices and methods of the present invention can be adapted to perform highly efficient lysis of microorganisms within a biological sample for diagnostic tests, for example for diagnosis of infectious agents and pathogens, such as bacteria, viruses or parasites.
Owner:BOSTON MEDICAL CENTER INC

Multi-purpose stovetop grilling and cooking device

InactiveUS7059318B2Reduce needFacilitate releaseDomestic stoves or rangesLiquid heating fuelEngineeringSupport surface
A cooking device for cooking items over a heat source has a base with an annular reservoir having an inside rim defining an opening, a substantially circular cooking plate supported by the base, a rack supported by the base over the cooking plate, and a lid supported by the base over the cooking plate and the rack. The base of the cooking device has an annular cooking plate supporting surface located radially outwardly from an outside rim of the annular reservoir, an annular rack supporting surface located radially outwardly from the cooking plate supporting surface, an annular lid supporting surface located radially outwardly from the rack supporting surface, an outer rim projecting radially outwardly and upwardly from the lid supporting surface, an upwardly-projecting annular sealing portion located intermediate the rack supporting portion and the lid supporting portion, an annular cooking plate retaining surface disposed radially outwardly from the cooking plate supporting surface, and discrete support elements projecting downwardly from the base. A reversible cooking plate has a grilling surface on one side and a griddle surface on an opposite side. In one position, the grilling surface is directed upwardly and is inclined at an angle, in a second position, the griddle surface is directed upwardly and is substantially horizontal. A rim of varying height extends around the periphery of the griddle surface and aligns the griddle surface at an angle when in the first position.
Owner:3844374 CANADA
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