7results about How to "Toxic reduction" patented technology

The present application discloses small molecule compounds having a naphthylamine structure and an application thereof. In the present application, the structure of a compound having a structure as shown in general formula (I) is as shown in the drawing. The compound and the pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof that are provided by the present application or the pharmaceutical composition provided by the present application can selectively induce autophagy in damaged mitochondria without affecting or only weakly affecting normal mitochondria, and further have superior metabolic stability and pharmacokinetic properties, lower toxicity, and better druggability.

The application discloses an improver for treating cadmium contaminated soil and a preparation method thereof, and belongs to the technical field of heavy metal contaminated soil treatment. The improver comprises the following raw materials: iron oxide, tri-potassium phosphate, biochar, corn sugar residue, xanthan gum, sodium citrate, vitamin E, arbutin, bilirubin and sodium bicarbonate. The improver is applied to cadmium contaminated soil, cadmium ions in the soil can be adsorbed and precipitated to form cadmium precipitates, the toxicity of the cadmium ions is reduced, earthworms ingest the cadmium precipitates into the body and fix them, so that the cadmium content in the soil is reduced. The improver can also promote the absorption, ingestion and digestion of cadmium ions by earthworms, maintain the normal physiological activities of the earthworms, reduce the toxic effect of cadmium on the earthworms, and make the earthworms better treat cadmium contaminated soil. The preparation method of the improver is simple, good in effect and friendly to the environment.

The present application discloses a small-molecule compound having a naphthalenethiol ether structure, and a use thereof. Disclosed in the present application are a compound having a structure represented by general formula (I), a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, a pharmaceutical composition containing the same, and a use thereof in the preparation of mitophagy inducer drugs. In the present application, the structure of the compound having the structure represented by general formula (I) is shown below. The compound and the pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, or the pharmaceutical composition provided in the present application can enhance the ability to induce mitophagy.

This invention relates to the field of catalytic dehydrogenation technology for hydrogen storage materials, and discloses a method for dehydrogenating hydrogen storage materials. The method includes: contacting the hydrogen storage material sequentially with a first dehydrogenation catalyst and a second dehydrogenation catalyst under dehydrogenation reaction conditions; wherein the hydrogen storage material includes a hydrogenated N-containing heterocyclic hydrogen storage material and an impurity component; the first dehydrogenation catalyst includes a first support and a first active component supported on the first support, the first active component being Cu; the second dehydrogenation catalyst includes a second support and a second active component supported on the second support, the second active component being at least one of noble metals; the volume ratio of the first dehydrogenation catalyst to the second dehydrogenation catalyst is 1:(1-9). The dehydrogenation method provided by this invention can adapt to hydrogen storage materials containing impurity components, exhibiting high reactivity and good long-term operational stability.

This invention relates to the field of biomedicine, specifically to a class of prodrug structures with ROS signal-responsive properties, their preparation methods, and applications. The prodrug molecules with ROS signal-responsive properties developed in this invention can rapidly release bioactive molecules in ROS-rich environments, achieving targeted therapeutic effects. This method has good universality and has been verified to be able to prodrugize various molecules, including four approved drug molecules, improving drug solubility, biocompatibility, reducing cytotoxicity, and enhancing targeted therapeutic effects. Based on the structural characteristics of these molecules, they can also complex with PVA hydrogels to further achieve responsive and controllable drug release.

The application provides an implant surface modification method for diabetic bone repair. In view of excessive oxidative stress and unbalanced immune homeostasis of a diabetic bone defect pathological microenvironment, the application constructs a bioactive surface interface (LBL-GA@Mn) containing an antioxidant nano-enzyme and a traditional Chinese medicine immunomodulator on the surface of an implant by using a layer-by-layer self-assembly technology (LBL). The application mainly comprises the following steps: Mn3O4-BSA antioxidant nano-enzymes are prepared by a hydrothermal method and an ultrasonic method, a chitosan-18beta-glycyrrhetinic acid conjugate (CS-GA) is synthesized by an EDC / NHS acylation reaction, a gelatin (Gel) / CS-GA polyelectrolyte multilayer film structure is constructed on the surface of an implant by using a layer-by-layer self-assembly technology (LBL), and Mn3O4-BSA is used as an intercalation component of the multilayer film, so as to obtain a bioactive surface LBL-GA@Mn modified bone injury implant. The application organically fuses a new material antioxidant nano-enzyme and a traditional Chinese medicine immunomodulator, and provides a new solution for synergistic treatment of inflammatory bone diseases such as diabetic bone defects.

The present application relates to a kind of monocotyledon green wisteria rapid propagation method, using the characteristics of green wisteria specific tissue cell totipotency, under open condition, using liquid medium to induce green wisteria specific site of in vitro leaf split differentiation, produce regenerative root and regenerative bud, finally form plant.The present application aims at the rapid propagation method of green wisteria leaf, without sterile environment, convenient to take material, easy to operate, low in cost, short in period, high in survival rate, with the advantages of high efficiency, economy, easy to scale, factory, etc., in green wisteria rapid seedling, specific material preservation and propagation has greater application value.