61results about How to "Less toxic" patented technology

The present invention is directed to novel therapeutic compounds comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. These high therapeutic index derivatives have the same utility as the drug from which they are made, and they have enhanced pharmacological and pharmaceutical properties. In fact, the novel drug derivatives of the present invention enhance at least one therapeutic quality, as defined herein. The present invention is also directed to pharmaceutical compositions containing same.

Disclosed herein are teeth whitening compositions generally including an oxidizing agent (e.g., a peroxide), and an activating agent that has an emission wavelength between about 400 nm and about 570 nm (e.g., Eosin B, Eosin Y, or Erythrosine B). Methods of employing these compositions to whiten teeth, methods of making these compositions and kits that include some or part of the composition ingredients, are also described.

ACE-2 modulating compounds for the treatment of body weight disorders are disclosed. Methods of using the compounds and pharmaceutical compositions containing the compounds are also claimed.

Disclosed herein are compositions and methods useful for the in vivo delivery bis(thiohydrazide amides), encased in a polymeric biocompatible shell.

The invention relates to a reduction etching liquid for base plates of sheet glass, components percentage by weight of which comprise: hydrofluoric acid holding 5-25%, strong acid holding 5-30% and pure water holding 45-90%. The reduction etching liquid for base plates of sheet glass of the invention is less in volatilization and toxicity. The using rate of the etching liquid is high and etching speed is rapid and stable. Costs of waste liquor treatment and subsequent treatment are low. The etching effect is excellent. Therefore, the invention has wide prospects for application.

The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.

The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor).

The invention features methods, compositions, and kits for treating a musculoskeletal disorder, e.g., osteoarthritis, or pain, fatigue, tenderness, impairment in mobility, soft tissue swelling, or bony swelling associated therewith, by administering to a patient diagnosed with or at risk of developing such pain, fatigue, tenderness, impairment in mobility, soft tissue swelling, or bony swelling a tetra-substituted pyrimidopyrimidine, e.g., dipyridamole, or an adenosine activity upregulator, in combination with one or more additional agents. The invention further features methods, compositions, and kits for treating a patient diagnosed with or at risk of developing a musculoskeletal disorder by administering to the patient a tetra-substituted pyrimidopyrimidine or an adenosine activity upregulator in combination with one or more additional agents.

A multi-junction photovoltaic cell device. The device includes a lower cell and an upper cell, which is operably coupled to the lower cell. In a specific embodiment, the lower cell includes a lower glass substrate material, e.g., transparent glass. The lower cell also includes a lower electrode layer made of a reflective material overlying the glass material. The lower cell includes a lower absorber layer overlying the lower electrode layer. In a specific embodiment, the absorber layer is made of a semiconductor material having a band gap energy in a range of Eg=0.7 to 1 eV, but can be others. In a specific embodiment, the lower cell includes a lower window layer overlying the lower absorber layer and a lower transparent conductive oxide layer overlying the lower window layer. The upper cell includes a p+ type transparent conductor layer overlying the lower transparent conductive oxide layer. In a preferred embodiment, the p+ type transparent conductor layer is characterized by traversing electromagnetic radiation in at least a wavelength range from about 700 to about 630 nanometers and filtering electromagnetic radiation in a wavelength range from about 490 to about 450 nanometers. In a specific embodiment, the upper cell has an upper p type absorber layer overlying the p+ type transparent conductor layer. In a preferred embodiment, the p type conductor layer made of a semiconductor material has a band gap energy in a range of Eg=1.6 to 1.9 eV, but can be others. The upper cell also has an upper n type window layer overlying the upper p type absorber layer, an upper transparent conductive oxide layer overlying the upper n type window layer, and an upper glass material overlying the upper transparent conductive oxide layer.

The invention provides compositions derived from brown-rot fungi that are suitable for use in bioremediation and similar applications where it is desirable to transform a target compound, often a toxic organic compound, into a different compound or compounds having more acceptable properties. The compositions are suitable for treating aqueous solutions or suspensions to reduce the amount of an undesired organic compound present, usually as one step in a treatment process to render the solution or suspension more suitable for environmental release. The invention also provides improved methods for growing fungal cultures for production of culture fluids.

The invention provides a preparation method for hydrogenated bisphenol A and a catalyst for hydrogenation of bisphenol A. The preparation method comprises hydrogenating bisphenol A at a temperature of 50-100 DEG C, under a hydrogen pressure of 5-10 MPa and at presence of a solvent isopropanol and a ruthenium catalyst, so as to generate hydrogenated bisphenol A, wherein the ruthenium catalyst is a Ru-Zn-Ni/TiO2-CdO catalyst, that is, the ruthenium catalyst takes zinc and nickel as auxiliary active compositions and takes titanium dioxide and cadmium oxide as a composite carrier. The conversion rate of bisphenol A can reach 100%, meanwhile the selectivity of hydrogenated bisphenol A is larger than 97%, and the purity of hydrogenated bisphenol A is 99.5% or more.

The invention provides conjugates of fatty amines and pharmaceutical agents useful in treating cancer, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of preparations of the fatty amine-pharmaceutical agent conjugates are provided.

The invention discloses an oil sludge demulsifier and an oil sludge resourceful treatment process. The oil sludge demulsifier comprises the following components in parts by weight: 5-30 parts of fatty acid methyl ester sulfonate, 2-10 parts of alkyl polyglucoside, 0.5-2 parts of a green accessory ingredient and 58-92 parts of water. The oil sludge resourceful treatment process comprises the following steps: enabling oily sludge in a raw material storage sludge tank to enter a sludge mixing tank; adding the oil sludge demulsifier for demulsification treatment; enabling demulsified oily sludge to enter a stacked spiral type sludge dewatering machine for solid-liquid separation to obtain a filter liquor and a sludge cake; enabling the filter liquor to enter a gas-liquid mixing tank to be mixed with air; enabling the mixture to enter a separation tank for three-phase separation of oil, water and sludge. The oil sludge resourceful treatment process can reduce the moisture content of oily sludge from 80-98% to about 50%, can further recycle most crude oil in oily sludge, and greatly reduces the difficulty of sludge follow-up treatment. By combining the oil sludge demulsifier with the oil sludge demulsification process, the moisture content of oil sludge can be reduced from 80-98% to about 50%, most crude oil in oil sludge can be further recycled, and the difficulty of sludge follow-up treatment is greatly reduced.

A proteomic screening method for anaerobic-specific and expression-effective promoter, and a method of specially delivering and selectively stably expressing target gene in anaerobic tissue by an alcohol dehydrogenase promoter and uses thereof. The latter comprises an anaerobically-induced alcohol dehydrogenase promoter which is used as target gene promoter, anaerobic target bacteria and low copy number plasmid. Therefore, the target gene can be specially and highly expressed under hypoxia condition in vivo or in vitro. The selective gene expression which is driven by the alcohol dehydrogenase promoter in anaerobic tissue can be used as gene therapy method to treat anaerobic tissue disease including tumor, or to prepare anti-tumor drug.

The invention relates to a method for carrying out living polymerization by directly using an industrial-grade monomer, in particular to a method for preparing polymethyl methacrylate by carrying out atom transfer radical polymerization (AGET ATRP) reaction generating a catalyst through electron transfer by directly using the monomer, i.e. industrial-grade methyl methacrylate containing a polymerization inhibitor, belonging to the field of organic polymerization. The method comprises the following steps of: adding the monomer, an initiator, the catalyst and a coordinating agent according to the mole ratio of monomer:initiator:catalyst:coordinating agent=(100-1000):1:(0.05-1):(0.15-3) by taking the industrial-grade methyl methacrylate as the monomer; and carrying out the atom transfer radical polymerization (AGET ATRP) reaction generating the catalyst through the electron transfer to synthesize a high molecular polymer under the catalysis of ferric salt. The invention decreases the steps of eliminating the polymerization inhibitor by carrying out the AGET ATRP polymerization by directly using the industrial-grade methyl methacrylate containing the polymerization inhibitor, simplifies the polymerization process and greatly reduces the production cost.

The invention relates to a coal asphalt material for paving a high-grade road and a preparation method of the coal asphalt material. The existing preparation method of the coal asphalt has the defects of low coal asphalt utilization rate, large modifier dosage, high cost, complicated process, poor material stability and the like. The method disclosed by the invention comprises the following steps: taking mid-low temperature coal asphalt, and hotly melting to obtain a sticky substance; adding a plasticizer, and adding anhydride compounds and a lewis acid after agitating; adding polyethylene glycol after heating reaction, and then dewatering after reacting again, so as to obtain the coal asphalt material for paving the high-grade road. By adopting the process, the condensation phenomenon of the coal asphalt at high temperature is removed, and the low-temperature fragility and the cracking property of the coal asphalt are changed, meanwhile, the toxic properties of polycyclic aromatic hydrocarbon are greatly reduced, the additional value of the coal asphalt is increased, and favorable economic benefits can be generated.

The invention discloses a method and device for absorbing and precipitating radionuclide in a containment of a nuclear power plant. The device for absorbing and precipitating radionuclide is mounted in the containment of the nuclear power plant in advance, and the device includes an absorption box containing high temperature resistant inorganic absorption material and two water tanks containing different formula solutions. In case that the nuclear power plant is in extreme events, a loop in the containment of the nuclear power plant is broken, and a great deal of high-temperature and high-pressure radioactive water with high concentration is to be released into the containment, the absorption material in the absorption box is serviced to absorb the radionuclide in the radioactive water; the solutions in two water tanks are automatically controlled or manually controlled to be emptied into the containment in sequence; two solutions are reacted with the radionuclide in the radioactive water with high concentration to generate precipitation; 131 I, 137 Cs and 90 Sr in the radioactive water with high concentration are absorbed and precipitated in the containment, as a result, the concentration of radioactive substances in the water in the containment is reduced; and the quantity of the radionuclide released to the atmospheric environment is reduced during releasing the pressure ofthe containment to exhaust gas or when the containment is broken.

The invention discloses a microcapsule capable of resisting food-borne pathogenic bacteria and a preparation method thereof and aims to provide the microcapsule which can effectively inhibit the food-borne pathogenic bacteria, has good stability, can improve the stability of essential oil in a storage process, is safe and has no side effects. The microcapsule capable of resisting the food-borne pathogenic bacteria is prepared by carrying out complex coacervation by taking sunflower essential oil and olive oil as a capsule core and taking natural edible gum as a capsule wall and curing by using a curing agent genipin. The microcapsule capable of resisting the food-borne pathogenic bacteria belongs to the technical field of bacterium resistance.

The invention provides conjugates of fatty alcohols and pharmaceutical agents useful in treating cancer, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of preparation of the fatty alcohols-pharmaceutical agent conjugates are provided.

The invention provides a medicinal paste for treating Chinese honeylocust spine and hyperosteogeny and its preparing process, wherein the raw material herbs include the following constituents (by weight ratio): Chinese angelica root, Chinese ephedra, rhubarb horsetails, radix paeoniae rubrathe, dried rehmannia root, goldthread root, licorice root, thunberg fritillary bulb, honeysuckle flower, safflower, stem pith of the ricepapr plant, dahurian angelica root, radix aconiti. and the preparing process steps of cooling down the plaster and charging the following fine materials: pangolin scales, camphor, musk, boneol, frankincense, myrrh, and dragon's blood resin.

The invention discloses a microRNA inhibitor, a microRNA inhibitor expression vector, a building method of the microRNA inhibitor expression vector and application of the microRNA inhibitor expression vector. The microRAN inhibitor is a dMAN (double mRNA adhesion nucleotide), and consists of three parts including a general straight chain complementary sequence, a general stem ring sequence and two miRNA combining region sequences. The built expression vector comprises two dMAN expression frameworks; two identical or different MANs can be transcribed at the same time; the utilization rate of the vector is higher; and the consumption and the toxicity of virus particles are lower. In an aspect of the building method, the dMAN building method is economic; only two pairs of primers of at most 60 basic groups need to be synthesized; and one-step cloning building comprising two MAN structure mRNA inhibition vectors can be completed through twice PCR (Polymerase Chain Reaction) and an enzyme digestion and connecting technology.

The invention provides Zn-chelating compounds that are molecularly engineered to bind to a specific target sequence in a protein of interest. The Zn²⁺ ion is far less toxic and promiscuous than nickel and therefore provides an attractive alternative to Ni-based labeling systems. Invention Zn-chelating compounds also do not require oxidizable thiols and therefore can be used in non-reducing environments such as the surface of living cells. In addition, the target sequence is genetically encodable and requires incorporation of only a few amino acids, unlike fusions to fluorescent proteins such as GFP.

The present invention provides methods for preparing complexed diaryl boronic acids from alkyl diarylborinates.

The invention relates to a test paper strip for detecting a P24 antigen and particularly relates to a preparation method of a carbon quantum dot test paper strip for detecting a P24 antigen. The preparation method comprises the following steps of: bonding a sample pad and a water absorption pad respectively at two ends of a bottom plate, preparing a P24 carbon quantum dot pad and a P24 nitrocellulose membrane, bonding the sample pad, the P24 carbon quantum dot pad, the P24 nitrocellulose membrane and the water absorption pad in a lapping way in sequence on the bottom plate to obtain a test paper plate, cutting the test paper plate into a plurality of test paper strips conforming to defined widths, and hermetically storing the test paper strips. According to the invention, a known specific antibody or antigen is fixed in a zone of the cellulose membrane at first, a sample to be detected is added on the sample pad, a carbon quantum dot marking reagent on the carbon quantum dot pad is dissolved, and a large amount of carbon quantum dots are gathered on a detection band, so that bright light is emitted and specific immunologic diagnosis is achieved. The method is high in sensitivity and low in toxicity or free from toxicity in a detection process.

The present invention provides compositions, methods, and kits for treating or preventing a viral infection (e.g., an infection caused by an influenza virus).

The invention relates to N,N-dimethyl-4-cyclohexylaminomethylcyclohexane as well as a preparation method and application thereof. The method comprises the following step of preparing the N,N-dimethyl-4-cyclohexylaminomethylcyclohexane by utilizing a byproduct deammoniated light component in an HMDA (Hexamethylene Diamine) reaction process, formaldehyde and hydrogen gas under the action of a catalyst and under certain temperature and pressure through hydrogenation and methylation. After being purified, the obtained N,N-dimethyl-4-cyclohexylaminomethylcyclohexane can be used as a polyurethane catalyst; effective utilization of an HMDA byproduct is realized and polyurethane foam prepared from the N,N-dimethyl-4-cyclohexylaminomethylcyclohexane has the advantages of low odor, good physical properties and the like.

A synthetic route is provided to prepare poly(ω-hydroxycarboxylic acid) polymers via the ring-opening polymerization of ω-hydroxycarboxylic acid cyclic oligomers. The cyclic oligomers can be prepared directly from biorenewable sources, such as 3-hydroxypropionic acid. The method can be used to prepare high molecular weight polymers from the cyclic oligomers. Good molecular weight control can be obtained for both solution state and melt polymerizations.

The invention relates to a method for preparing dronedarone hydrochloride, comprising the following concrete steps of: (1) carrying out etherification reaction on 2-butyl-3-(4-hydroxy benzoyl)-5-nitro benzofuran and 1-bromine-3-chloropropane in an organic solvent so as to obtain 2-n-butyl-3-[4-(3-chlorine propoxy) benzoyl]-5-nitro benzofuran; (2) reducing to 2-n-butyl-3-[4-(3-chlorine propoxy) benzoyl]-5-amido benzofuran by utilizing a reductant; (3) carrying out sulfamide reaction with methyl sulfonyl chloride in the organic solvent so as to obtain 2-n-butyl-3-[4-(3-chlorine propoxy) benzoyl]-5-methyl sulfonamide benzofuran; (4) carrying out N-hydrocarbon reaction with di-n-butylamine so as to obtain the dronedarone; and (5) salifying the dronedarone hydrochloride and obtaining the dronedarone hydrochloride. The method provided by the invention has the advantages that the reaction route is simple, the raw material is cheap and easy to obtain and the reaction condition is mild and easy to control and is suitable for industrialized production.

The invention discloses medium-temperature silver-free copper-based brazing filler metal and a method for preparing the same. The medium-temperature silver-free copper-based brazing filler metal comprises, by weight, 4.0%-7.5% of P, 1.0%-15.0% of Sn, 0.5%-2.0% of Si, 0-1.0% of Sb, 0.3%-0.8% of B, 0.2%-1.0% of Ti, 0.2%-0.8% of Zr, 0-2.0% of Ni and the balance Cu. The medium-temperature silver-free copper-based brazing filler metal and the method have the advantages that the copper is used as a matrix for the medium-temperature silver-free copper-based brazing filler metal, diversified non-toxic and inexpensive metal elements are added into the copper, accordingly, characteristics of the medium-temperature silver-free copper-based brazing filler metal can be improved, and the medium-temperature silver-free copper-based brazing filler metal is excellent in braze welding technological characteristic; the medium-temperature silver-free copper-based brazing filler metal is prepared to obtain powder, has low melting temperature and is excellent in braze welding technological performance such as joint filling properties and wetting properties; the medium-temperature silver-free copper-based brazing filler metal prepared by the aid of the method can be flexibly used, is adaptive to weld joints in diversified shapes and is excellent in quality stability.

The invention discloses a cold chain coolant that is characterized by being prepared from, by mass, 5%-10% of metal chloride, 1%-4% of ammonium chloride, 1%-3% of alcohol, 0.1%-0.3% of active silicon,2%-5% of borax, 0.3%-1% of docusate sodium, 5%-10% of amino-terminated polyethylene glycol amidated pectic acid, 2%-4% of aleuritic acid group organic salt and the balance water, wherein the aleuritic acid group organic salt is prepared by carrying out ion exchange reaction on aleuritic acid and choline. The invention further discloses a preparation method of the cold chain coolant. The cold chain coolant disclosed by the invention has the advantages of large latent heat, small supercooling degree, good heat transfer, good cold chain effect, small toxicity and pollution, high cold chain efficiency and long cold storage time.