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Methods and apparatus are disclosed for applying acoustic energy to the skin. Acoustic waveguides with elements of varying thickness or shape are disclosed which deliver energy to more than one depth below a surface of the skin substantially simultaneously. The invention is especially useful with devices that focus ultrasound energy by condensing a propagating wavefront. The invention compensates for the mismatch in acoustic properties of the device's waveguide and the biological tissue that typically cause portions of the collapsing wavefront to lag behind other portions and, thereby, limit the focusing capabilities of acoustic treatment devices.

Disclosed are Bacillus thuringiensis strains comprising novel crystal proteins which exhibit insecticidal activity against lepidopteran insects. Also disclosed are novel B. thuringiensis genes and their encoded crystal proteins, as well as methods of making and using transgenic cells comprising the novel nucleic acid sequences of the invention.

Methods and apparatus are disclosed for applying acoustic energy to the skin whereby the wavefront can be controlled to confine the focused energy to a desired subsurface region. Acoustic waveguides are disclosed which compensate for distortions that otherwise occur when a focused acoustic beam crosses a boundary, such as the transition from a treatment device to a target region of skin. The invention is especially useful with devices that focus ultrasound energy by condensing a propagating wavefront. The invention compensates for the mismatch in acoustic properties of the device's waveguide and the biological tissue that typically cause portions of the collapsing wavefront to lag behind other portions and, thereby, limit the focusing capabilities of acoustic treatment devices.

The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.

Methods and apparatus are disclosed for dispensing fluid in an apparatus for applying acoustic energy to the skin. Acoustic waveguides are disclosed which compensate for distortions that otherwise occur when a focused acoustic beam crosses a boundary, such as the transition from a treatment device to a target region of skin. The invention is especially useful with devices that focus ultrasound energy by condensing a propagating wavefront. The invention compensates for the mismatch in acoustic properties of the device's waveguide and the biological tissue that typically cause portions of the collapsing wavefront to lag behind other portions and, thereby, limit the focusing capabilities of acoustic treatment devices.

A vehicle mirror has a mirror glass (1) which also forms a substrate for an OLED display (7). This OLED display (7) fully covers the mirror glass (1). A front cover glass (5) forms the second substrate for the OLED display (7).

An auxiliary light source such as a flash is controlled for highly accurately reflecting a lighting condition with less effect of a factor other than the lighting condition such as contrasting density caused by shadow or black compression or white compression. For this purpose, a parameter acquisition unit obtains weighting parameters for principal components representing lighting conditions in a face region in an image detected by a face detection unit, by fitting to the detected face region a mathematical model generated according to a method of AAM using a plurality of sample images representing human faces in different lighting conditions. A flash control unit obtains a flash control condition by referring to a reference table according to the parameters, and controls flash light emission according to the control condition.

An exposure value is determined based on a face region, with high accuracy and with less effect of a background region or density contrast caused by shadow. For this purpose, a face detection unit detects a face region from a face candidate region in a through image detected by a face candidate detection unit, by fitting to the face candidate region a mathematical model generated by a method of AAM using a plurality of sample images representing human faces. An exposure value determination unit then determines an exposure value for photography, based on the face region.

A cartridge for an electrical immobilization weapon for optimized effectiveness and accuracy, comprising: a housing means for accommodating first and second projectiles adapted for being spaced within a targeted portion, having a length of at least from 5 inches to 25 inches, of a human body and for transmitting the electrical energy to the target; connecting means having at least one such length for interconnecting the first and second projectiles and available outside the housing means for retaining the projectiles within the said length in between thereof; means including the housing means for separating the first and second projectiles for immediately achieving a said length in between after leaving the housing means; means secured to the housing means for propelling the projectiles from the housing means for reaching the targeted portion; and means for coupling the projectiles to the electrical energy of the weapon's power supply.

A capacitive sensing system is used to measure a time-varying ion current through a channel, such as an ion channel or protein pore. Such a capacitive system does not suffer problems of electrode corrosion and, when used with methods to control a build up of ion concentration, allows the use of measurement volumes around the channel with dimensions on a scale of nanometers.

The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In some embodiments, methods and compositions involve poxviruses that possess mutations that result in poxviruses with diminished or eliminated capability to implement an antiviral response in a host. Poxviruses with these mutations in combination with other mutations can be employed for more effective treatment of cancer.

The present invention relates to a new pharmaceutical product containing an antiprogestin molecule, such as mifepristone (RU486), administered by the nasal route and to be used to modulate the timing of the spontaneous LH surge as part of follicular stimulation cycles intended for Assisted Reproductive Technology (ART). In particular, it details the route of administration and the dosages that ensure effective delay of the LH surge without incurring in the antifolliculogenetic effects of the antiprogestinic. It also details the overall treatment method as resulting from the use of the new drug product.

There is a ground-fault resistance measurement circuit which measures a ground-fault resistance between a conductive frame body of electrical equipment and a charge section insulated from the frame body. This ground-fault resistance measurement circuit includes: a capacity which is connected between the charge section and the frame body; a switch which opens and closes a connection path between the charge section and the capacity; a charging unit which charges the capacity to a predetermined voltage; a voltage measurement section which measures a charging voltage of the capacity; a discharge control section which connects the capacity and the charge section after the capacity is charged, and discharges the capacity; and a calculation section which calculates a resistance between the charge section and the frame body, based on a change in the charging voltage of the capacity.

GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and / or improved chemical stability, e.g., as assessed in in vitro stability assays. More particularly, preferred GLP-2 analogues disclosed herein comprise substitutions at one or more of positions 8, 16, 24 and / or 28 of the wild-type GLP-2 sequence, optionally in combination with further substitutions at position 2 (as mentioned in the introduction) and one or more of positions 3, 5, 7, 10 and 11, and / or a deletion of one or more of amino acids 31 to 33 and / or the addition of a N-terminal or C-terminal stabilizing peptide sequence. The analogues are particularly useful for the prophylaxis or treatment of stomach and bowel-related disorders and for ameliorating side effects of chemotherapy. Also disclosed are methods and kits for selecting a patient from populations suited for treatment with GLP-2 analogues.

A predistortion control device (1). The device has a first predistortion control input connectable to a power amplifier output (21); a second predistortion control input (11) connectable to a signal contact of a predistortion device; and a predistortion control output (12) connectable to a control contact of the predistortion device. The predistortion control device (1) further includes a cross-correlator device (110). The cross-correlator device (110) is connected with a first cross-correlator input (1101, 1101I, 1101Q) to the first predistortion control input and a second cross-correlator input (1102, 1102I, 1102Q) to the second predistortion control input (11). The cross-correlator device (110) is further has a cross-correlator output (1112) at which a cross-correlation signal can be presented, the cross-correlation signal representing a measured cross-correlation of signals presented at the first cross-correlator input (1101, 1101I, 1101Q) and the second cross-correlator input (1102, 1102I, 1102Q). The predistortion control device (1) further has a predistortion function selector device (120)(120), connected with a selector input to the cross-correlator output (1112), and with a selector output to the predistortion control output (12), at which selector output a predistortion control signal can be presented. The predistortion control signal representing a predistortion function determined on the basis of said cross-correlator signal.

A singlet telescope is provided for reshaping the laser beam to a larger or smaller diameter while maintaining the inherent quality of the beam. Applications for the singlet telescope include intercavity expansion to accommodate the damage thresh-old of various components, expansion of beams to match the size of different wavelengths for final collimation, and shrinking of beams to provide high irradiance for nonlinear processes such as optical parametric oscillation and frequency doubling, with the above applications usually requiring low power magnification or demagnification. Problems involving the utilization of these telescopes over wide temperature ranges and ghost reflections in which a light is reflected back to a pumping laser are minimized with the singlet construction, with the ghost reflections potentially creating damage of components including self-damage or breakdown of air, as well as damage to a Q-switched resonator which causes pre-lasing.

A double tank refrigerated carbonated beverage dispensing apparatus for blending fresh water and carbon dioxide to produce a carbonated liquid delivered to a faucet bank for dispensing mixed soft drinks at a temperature at or below the freezing point of water, includes a double tank carbonator having in inner tank contained within an outer tank, insulated by a void between the two tank, the void having refrigeration coils connected to a refrigeration circulation system. The apparatus includes a soda water circulating system, a heat exchange unit for pre-cooling water and beverage syrup lines, syrup coils adapted to the double tank carbonator for chilling some beverage syrup lines, temperature sensors for regulating temperature of the carbonated water and fluid level probes to regulate the amount of water delivered to the double tank carbonator.

A film comprises: a transparent support; and an anti-glare layer having a haze value due to internal scattering of from 0 to 40% and a haze value due to surface scattering of from 0.3 to 20%.

There is a ground-fault resistance measurement circuit which measures a ground-fault resistance between a conductive frame body of electrical equipment and a charge section insulated from the frame body. This ground-fault resistance measurement circuit includes: a capacitor which is connected between the charge section and the frame body; a switch which opens and closes a connection path between the charge section and the capacitor; a charging unit which charges the capacitor to a predetermined voltage; a voltage measurement section which measures a charging voltage of the capacitor; a discharge control section which connects the capacitor and the charge section after the capacitor is charged, and discharges the capacitor; and a calculation section which calculates a resistance between the charge section and the frame body, based on a change in the charging voltage of the capacitor.

An anti-sifting polygonal carton stores granulated and powdered products. The carton starts as a single blank with four sections: a side, a front, a side, and a rear. The sides have a side panel with two flanking miter panels and two minor flaps. Each miter panel has two opposite miter flaps with embossing. The front has a front panel with a second major flap having a tear strip and an opposite second major lower flap having a crease. Separated from the front by a side, the rear has a rear panel having a miter tab opposite the side and a first major flap and an opposite first major lower flap. The fold lines continuous with the miter flaps and the miter tab are reinforced with tape or patches. The tear strip and top of the carton have a pattern of cuts to open and to reclose the carton.

The present invention relates to a crosslinkable composition comprising at least one crosslinkable component crosslinkable by a latent base crosslinking catalyst comprising a substituted carbonate salt according to formula 1 wherein X+ represents a cation and wherein R is hydrogen, alkyl, aryl or aralkyl group, and wherein the crosslinkable composition comprises 0.1-10 wt %, preferably 0.1-5, more preferably 0.2-3 and most preferably 0.5-1.5 wt % water (relative to total weight of the crosslinkable composition). The invention further relates to a coating composition comprising the crosslinkable composition according to the invention, a novel catalyst composition and to the use of said catalyst composition according to the invention as a latent base crosslinking catalyst in coating compositions, preferably in RMA crosslinkable compositions.

Frozen aerated packaged ice confection with very high softness at −18° C. which keeps this property without shrinkage or layering up to the final consumer over the product shelf life contains polyol and vegetable fiber.

Frozen aerated packaged ice confection with very high softness at −18° C. which keeps this property without shrinkage or layering up to the final consumer over the product shelf life contains polyol and vegetable fibre.

The disclosed invention relates to novel norbornene-type monomers containing pendent lactone or sultone groups. The invention also relates to norbornene-type polymers and copolymers comprising one or more repeating units represented by the formula:and containing pendent lactone or sultone groups. These polymers and copolymers are useful in making photoimagable materials. The photoimagable materials are particularly suitable for use in photoresist compositions useful in 193 and 157 nm photolithography.

An energy storage device, such as a silver oxide battery, can include a silver-containing cathode and an electrolyte having an ionic liquid. An anion of the ionic liquid is selected from the group consisting of: methanesulfonate, methylsulfate, acetate, and fluoroacetate. A cation of the ionic liquid can be selected from the group consisting of: imidazolium, pyridinium, ammonium, piperidinium, pyrrolidinium, sulfonium, and phosphonium. The energy storage device may include a printed or non-printed separator. The printed separator can include a gel including dissolved cellulose powder and the electrolyte. The non-printed separator can include a gel including at least partially dissolved regenerate cellulose and the electrolyte. An energy storage device fabrication process can include applying a plasma treatment to a surface of each of a cathode, anode, separator, and current collectors. The plasma treatment process can improve wettability, adhesion, electron and / or ionic transport across the treated surface.

A valve assembly for controlling the amount of coolant exiting an engine is provided. The valve assembly includes a valve housing that is mounted to the engine and defines a passage that is in fluid communication with a coolant outlet in the engine. A motor in the valve housing drives a valve shaft that extends into the passage and on which a butterfly valve plate is mounted. The physical geometry of the inventive assembly is not significantly effected by changes in coolant temperature or coolant contamination and the integrates the valve member and actuator in a single assembly to improve packaging and material use and eliminates potential coolant leak points.

The present invention relates generally to a mathematical and computer model of diabetes related disorders (e.g., human type 2 diabetes) within the framework of multiple macronutrient metabolism. The model includes a representation of complex physiological control mechanisms directing, for example, fat metabolism, protein metabolism and / or carbohydrate metabolism. In one embodiment, for example, the model can account for the interconversion between macronutrients, as well as their digestion, absorption, storage, mobilization, and adaptive utilization, as well as the endocrine control of these processes. In this embodiment, the model can simulate, for example, a heterogeneous group of diabetes related disorders, from insulin resistant to severe diabetic, and can predict the likely effects of therapeutic interventions.

The invention discloses a computer input device with Bluetooth hand-free handset comprises: an electric source module, for providing power to the computer input device, comprising a voltage step-up circuit and a battery, in which the battery can be an one-time-battery or a rechargeable battery used as the electric source for the computer input device; an optical mouse circuit, for detecting movement vector caused by a movement of the computer input device by the principles of optical transmitting and receiving; a Bluetooth module, coupled to the optical mouse circuit, wherein the module is further connected to an antenna for transmitting / receiving signals, a power LED for indicating whether the computer input device is powered, and a link LED for indicating whether the computer input device is in a communication state; an echo cancellation circuit, coupled to the Bluetooth module and used for canceling echoes of audio signals; a sound receptor, coupled to the echo cancellation circuit for receiving the audio signals; an audio signal amplifying circuit, coupled to the echo cancellation circuit for receiving and amplifying the audio signals outputted from the echo cancellation circuit; and a loudspeaker, coupled to the audio signal amplifying circuit for playing sounds corresponding to the audio signals from the audio signal amplifying circuit.