57 results about "Esophageal reflux" patented technology

The invention relates to the technical field of monitoring, and particularly discloses an anti-esophageal reflux monitoring system for old patients with dysphagia, which is used for solving the problems of oesophageal elastic degeneration, frequent body position change, low swallowing amplitude and the like of the old patients with dysphagia. Therefore, the problem that an existing reflux monitoring system based on single-point sensing, static threshold control and periodic model updating cannot meet the dynamic reflux early warning requirements of individualization, high sensitivity, real-time performance and low power consumption is solved. Comprising a wearable esophagus comprehensive monitoring module, a body position and esophagus deformation recognition module, a personalized pressure threshold self-adaption module, an intelligent prediction and early warning module, an air bag execution module and a cloud model training and updating module. According to the invention, multi-modal sensing and dynamic threshold, self-adaptive sampling and online model fine tuning are fused, low-amplitude swallowing and early-stage reflux signals are effectively captured, the iteration period is shortened by cloud differential updating, the equipment endurance is prolonged, and the esophageal injury risk is reduced.

The invention provides an intervention method and system for esophageal reflux in airway management, and relates to the technical field of medical treatment. The method comprises the following steps: S1, collecting a risk assessment result of whether a patient has the risk of esophageal reflux aspiration or not; s2, under the condition that the patient has the risk of esophageal reflux aspiration, the current body position of the patient is recognized; based on the current body position, a target body position is judged, and a body position adjusting scheme is generated; and S3, adjusting the body position of the upper limb and / or the lower limb of the patient through a body position adjusting device, and moving the limb of the patient from the first position to the second position, so that the limb of the patient reaches the characteristics conforming to the target body position in the body position adjusting scheme. According to the method, the body position adjusting scheme can be generated based on the current body position of the patient, and the current body position of the patient is adjusted, so that the risk of esophageal reflux aspiration caused by an inappropriate body position is reduced.

The invention provides an application of a Lactobacillus paracasei IOB413 metagen in gastroesophageal reflux, and belongs to the technical field of microbial fermentation. The lactobacillus paracasei IOB413 metagen can relieve weight loss of gastroesophageal reflux rats, inhibit esophageal reflux, relieve esophageal tissue pathological injury, relieve inflammatory injury by reducing the levels of inflammatory factors IL-17 and IL-8, and enhance gastrointestinal motility and reduce the risk of reflux by improving the motilin level.

The invention provides a recessive gastroesophageal reflux event data analysis system and method based on dynamic changes of abdominal pressure. The system and method are suitable for noninvasive detection of atypical reflux clinically. The system comprises an abdominal pressure dynamic detection unit, a throat vibration detection unit, a multi-mode signal processing module, a reflux event judgment module and a data output module. According to the system, by analyzing time sequence linkage between abdominal pressure mutation and throat vibration, a stomach content countercurrent event is recognized, silent type countercurrent characteristic sound is captured with the assistance of a bone conduction sound wave channel, and multi-path redundancy recognition is achieved. The method is suitable for postoperative patients, children, old people and other people who cannot complain, has the technical advantages of continuous wearing, behavior correlation analysis and clinical verifiability, and significantly improves the recognition rate and diagnosis accuracy of recessive gastroesophageal reflux events.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating gastroesophageal reflux cough and a preparation method thereof. The traditional Chinese medicine composition disclosed by the invention is constructed by carefully selecting a medicine formula under the guidance of a traditional Chinese medicine theory and clinical experience and through a compatibility theory of monarch, minister, assistant and guide of traditional Chinese medicines. In the traditional Chinese medicine composition, the inula flower has the effects of promoting blood circulation, removing stasis and turbidity, clearing the airway and removing phlegm and fluid retention, and the mangnolia officinalis has the effects of promoting qi circulation, removing food retention, calming adverse-rising energy and relieving asthma, and both serve as monarch drugs; the dried orange peel has the effects of regulating qi and removing stagnation, the poria cocos has the effects of tonifying spleen, eliminating dampness and phlegm and breaking up the source of phlegm, and the bulbus fritillariae cirrhosae has the effects of clearing heat and moistening lung and resolving phlegm and relieving asthma; the rhizoma atractylodis macrocephalae has the effects of invigorating the spleen, replenishing qi, eliminating dampness and inducing diuresis, and the endothelium corneum gigeriae galli has the effects of promoting digestion and invigorating the stomach and is an assistant and guide drug. The whole prescription is ordered in monarch and minister, focuses on pathogenesis, is rigorous in prescription, has the effects of relieving cough and asthma, clearing heat and moistening lung, and strengthening spleen and stomach, and treats both symptoms and root causes of cough.

The gastroesophageal collar being submitted for patent intends to primarily prevent the ascension of the fundus above the diaphragmatic plane and also secondarily to improve the function of the Lower esophageal sphincter, thirdly to reduce occurrences of esophageal reflux and thereby hopefully reducing instances of esophageal cancer. It is estimated as high as %20 of the general population has a hiatal hernia experiencing symptoms of acid reflux and making them at higher risk for esophageal cancer. Currently the standard surgical repair of hiatus is fundoplication. The limitations of fundoplication are its high recurrence rate. It often requires a later second procedure to repair / tighten the fundoplication. By using supple bio-inert materials we intend to create a collar that can be left in place, mechanically preventing the ascension of the fundus and improving LES function. We hope to be the first Collar to prevent hiatal hernia and also improve LES function.

The present invention relates to an anti-respiratory obstruction device during anesthesia nursing, belonging to the field of medical device technology, comprising an oropharyngeal folding pressure plate, an airway intubation channel, an esophageal intubation hole, an esophageal reflux prevention tube, an oral secretion suction hole, a monitoring camera and a central controller. The present invention provides an anti-respiratory obstruction device that is simultaneously equipped with an esophageal reflux prevention blocking structure, an oral secretion infiltration prevention structure and an airway clearing monitoring structure. The esophageal reflux prevention tube is combined with an inner monitor to facilitate preventive monitoring and timely suction of reflux when obstruction occurs. The oropharyngeal folding pressure plate is used to moderately press the oropharynx in combination with the oral secretion suction hole thereon, which is conducive to clearing secretions in real time to prevent secretions that may cause obstruction from entering the oropharynx and airway. The air vent is provided to ensure assisted breathing when respiratory obstruction occurs, ultimately achieving comprehensive prevention of respiratory obstruction and effective and rapid treatment when respiratory obstruction occurs.

The present application relates to the field of food technology, and specifically discloses a composition for reducing gastroesophageal reflux in individuals, a preparation method and application thereof. The composition for reducing gastroesophageal reflux in individuals comprises beta-defensin 1, lysozyme and lactoperoxidase. The present application constructs a multi-target synergistic intervention mechanism combining physical protection, secretion regulation and tissue repair through the compounding of four core components, which can comprehensively block the occurrence and development of gastroesophageal reflux. Lactadherin constructs a physical barrier to reduce the risk of reflux dynamics from the source; MLCT precisely regulates gastric acid secretion to reduce chemical stimulation; HMO complex IgG strengthens the mucosal immune barrier and promotes damage repair. The above composition is applied to products for reducing gastroesophageal reflux in individuals, and multi-target synergistic effect is achieved, realizing a full-chain closed-loop intervention from prevention, relief to repair, and significantly improving the clinical improvement effect.

The present invention discloses an asymmetric anastomat with anti-reflux effect for esophagogastric anastomosis, the improvements lie in that the end face of a nail bin is formed by two arc-shaped plates that are bent towards the same direction and connected and closed in an end-to-end manner to form an arc-shaped cavity, nail outlet holes in the arc-shaped plates are provided around the arc-shaped cavity, and a cutter is consistent with the arc-shaped cavity in shape and is attached to the edge of the inner side wall of the arc-shaped cavity; a stapling anvil plate on the bottom face of the nail abutting base is formed by working out a cutting groove in a circular plate, the shape of the cutting groove is consistent with the shape of the arc-shaped cavity in the end face of the nail bin, and nail abutting grooves that match the nail outlet holes in position and shape are formed in the stapling anvil plate. After anastomosis with the asymmetric anastomat for esophagus and stomach in the present invention, redundant esophageal and gastric tissues on the anterior wall are deformed into the stomach to form a tongue piece by suturing to a seromuscular layer, and, in conjunction with manual folding and suturing at the posterior wall, valvula-like tongue pieces that are closed towards each other are formed in the stomach cavity, so that a valvula-like structure is formed together. The anastomotic stoma passage is in a valvula-like closed state when no food is eaten, and the anastomotic stoma is opened due to the peristalsis pressure of the esophagus and an expansion effect of a food mass during eating, so that a cardia-like effect of preventing stomach-esophageal reflux is achieved.

The present invention relates to a cannula device for integrated detection of esophageal reflux and vomiting reflex and an application method, including a cannula, and a ring-shaped detection head is provided at the front end of the cannula; a plurality of petal-shaped airbags are distributed on the outer surface of the detection head, and the plurality of airbags are communicated through an air duct, and the other end of the air duct extends outside the cannula; the device further includes an inflation / deflation unit and a barometric pressure sensor; an annular liquid accumulation groove is provided on the inner wall of the detection head, a circular ring-shaped slide rail is provided on the inner wall of the liquid accumulation groove, and a PH detection probe is slidably arranged on the slide rail; a plurality of liquid outlet holes are provided on the outer surface of the detection head, one or more liquid outlet holes are provided in the middle gap between adjacent airbags, and the liquid outlet holes are closed when the airbags are inflated; by applying the method of the present application, reliable monitoring results of vomiting reflex actions and monitoring results of esophageal reflux can be provided for medical staff, so that a reaction can be made immediately when there is a risk of aspiration, providing guarantee for the personal safety of patients.

The present application relates to the field of special medicine, and more specifically, it relates to a thickening component for special medical purposes for dysphagia and gastroesophageal reflux and a preparation method. A thickening component for special medical purposes for dysphagia and gastroesophageal reflux, comprising modified starch and xanthan gum; wherein the mass ratio of modified starch to xanthan gum is (7~9.5):(3~0.5). The preparation method is as follows: fully hydrating the modified starch to obtain a modified starch solution; spray drying part of the modified starch solution to prepare a powder; spraying the xanthan gum solution from the bottom of a fluidized bed to granulate the modified starch powder; spraying the remaining modified starch solution from the top of the fluidized bed to coat the above granulation, and sieving after hot air drying to obtain the finished product. The present application has the advantage of simultaneously improving the symptoms of dysphagia and gastroesophageal reflux.

The invention discloses application of a miR-34b-5p inhibitor in preparation of a medicine for treating gastrointestinal diseases, and belongs to the technical field of biological medicines. The miR-34b-5p inhibitor disclosed by the invention is derived from exosome derived from gastric juice of a gastroesophageal reflux patient. The polypeptide can be used for regulating the influence of the gastric juice exosome of a gastroesophageal reflux patient on an epithelial cell barrier, so that symptoms are improved, inflammatory response is relieved, a new target spot and scheme are provided for treating gastroesophageal reflux diseases, and the polypeptide has important clinical value and good clinical application prospects.

Disclosed are tetrahydroisoquinoline compounds useful for treating an opioid receptor-associated condition including pain, immune disease, esophageal reflux, diarrhea, anxiety, or heroin addiction. Also provided are pharmaceutical compositions and treatment methods.

The utility model discloses a reinforced mouth-nose-stomach esophagus which comprises a stomach esophagus body. The gastroesophagus comprises a tube body, a tube head located at the front end of the tube body and a tube tail located at the rear end of the tube body, the tube head, the tube body and the tube tail are integrally formed and sequentially communicated, the end, away from the tube body, of the tube head is a closed end, and the end, away from the tube body, of the tube tail is an open end and used for being detachably installed and matched with an external funnel. A spiral thread section is embedded in the pipe wall of the pipe body in the length direction, and a plurality of side holes are formed in the pipe head. The gastroesophageal tube can ensure that the tube passes through the esophageal section more smoothly, the reinforcing effect is achieved, the distortion and folding probability of the tube can be reduced, the spiral wire section increases the contact area between the tube and the narrow part of the esophagus, and gastroesophageal reflux is effectively prevented or relieved.

The invention belongs to the technical field of gastroscopy, and particularly relates to an auxiliary device for gastroesophageal reflux examination, which comprises an expansion and shrinkage sleeve assembly and a gastroscope assembly, the diameter of the expansion and shrinkage sleeve assembly can be changed, when the diameter of the expansion and shrinkage sleeve assembly is at the minimum value, the diameter of the expansion and shrinkage sleeve assembly is smaller than that of the gastroscope assembly, and when the diameter of the expansion and shrinkage sleeve assembly is at the minimum value, the diameter of the gastroscope assembly is smaller than that of the gastroscope assembly. When the diameter of the expansion and shrinkage sleeve assembly is at the maximum value, the gastroscope assembly can be inserted into the expansion and shrinkage sleeve assembly in a sliding mode. The double-layer cannula insertion structure is adopted, firstly, the expansion and shrinkage cannula assembly which is small in diameter and is in a shrinkage state is inserted into the esophagus, and therefore the discomfort of a patient is reduced; then, the expansion-shrinkage sleeve assembly is unfolded and converted into a hollow tube structure with a larger diameter from a folded and shrunk state, and then the gastroscope assembly is inserted into the expansion-shrinkage sleeve assembly, so that insertion of the gastroscope is completed.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating gastroesophageal reflux cough and a preparation method thereof. The traditional Chinese medicine composition disclosed by the invention is constructed by carefully selecting a medicine formula under the guidance of a traditional Chinese medicine theory and clinical experience and through a compatibility theory of monarch, minister, assistant and guide of traditional Chinese medicines. In the traditional Chinese medicine composition, the inula flower has the effects of promoting blood circulation, removing stasis and turbidity, clearing the airway and removing phlegm and fluid retention, and the mangnolia officinalis has the effects of promoting qi circulation, removing food retention, calming adverse-rising energy and relieving asthma, and both serve as monarch drugs; the dried orange peel has the effects of regulating qi and removing stagnation, the poria cocos has the effects of tonifying spleen, eliminating dampness and phlegm and breaking up the source of phlegm, and the bulbus fritillariae cirrhosae has the effects of clearing heat and moistening lung and resolving phlegm and relieving asthma; the rhizoma atractylodis macrocephalae has the effects of invigorating the spleen, replenishing qi, eliminating dampness and inducing diuresis, and the endothelium corneum gigeriae galli has the effects of promoting digestion and invigorating the stomach and is an assistant and guide drug. The whole prescription is ordered in monarch and minister, focuses on pathogenesis, is rigorous in prescription, has the effects of relieving cough and asthma, clearing heat and moistening lung, and strengthening spleen and stomach, and treats both symptoms and root causes of cough.

The utility model relates to the technical field of gastroesophageal reflux prevention, and discloses a gastroesophageal reflux prevention pillow which comprises a first base plate, a hinge is arranged on the outer wall of the first base plate, a second base plate is arranged on the outer wall of the hinge, a plurality of neck massage blocks are arranged on the outer wall of a connecting belt, and the neck massage blocks are arranged on the outer wall of the connecting belt. A plurality of elastic belts are fixedly sewn on the left side of the connecting belt, an air bag body is movably attached between the first base plate and the second base plate, and an inflation nozzle is arranged on the outer wall of the air bag body. According to the gastroesophageal reflux prevention bolster, when the gastroesophageal reflux prevention bolster needs to be stored, an inflation nozzle is opened, a bolt is twisted to take out the gastroesophageal reflux prevention bolster, a sliding frame is rotated to correspond to a sliding hole, the bolt is twisted into the inner wall of the sliding hole, a telescopic structure can be fixed to one side of a first pressing plate, and at the moment, a first base plate and a second base plate are extruded; the first pressing plate and the second pressing plate on the two sides are squeezed towards the middle, the effect of shrinking the back cushion can be achieved, and the effect of being convenient to carry can be achieved.

The invention discloses a gastroesophageal reflux AI auxiliary typing method based on esophageal function and morphological characteristics, and belongs to the technical field of gastroesophageal reflux, a first index parameter is acquired, esophageal functional characteristics are evaluated by using a pre-training model according to the first index parameter, and a functional score is calculated; wherein the first index parameter comprises a high-resolution esophageal power index parameter and an esophageal pH-impedance combined index parameter; obtaining esophageal endoscopic image index parameters, and according to the esophageal endoscopic image index parameters, evaluating the severity of the foraminal hernia defect and cardia relaxation by using the deep learning convolutional neural network prediction model, and calculating a morphological score; comprehensively evaluating the severity of the gastroesophageal reflux according to the functional score and the morphological score, and completing the precise typing of the gastroesophageal reflux. The severity of esophageal dysfunction and morphological defect is effectively evaluated based on a comprehensive index evaluation system, and precise typing of gastroesophageal reflux disease is completed.

The invention relates to the technical field of medical instruments, in particular to an external compression device for preventing esophageal regurgitation, which comprises a belt ring, a groove is formed in the outer side of one end of the belt ring, a plurality of adjusting teeth are fixedly mounted in the groove at equal intervals, and the other end of the belt ring is fixedly sleeved with a limiting seat. A sponge lining, a pressure air bag and a plurality of air pillows are fixedly installed on the inner side of the belt ring, a detection hose is fixedly inserted into the side face of the pressure air bag, and a pressure gauge is fixedly installed at the end, away from the pressure air bag, of the detection hose; the device has the advantages that the belt ring is wound around the neck of a patient, the belt ring is driven to be slowly tightened through the adjusting mechanism, the tightness of the belt ring can be accurately adjusted through the arranged adjusting mechanism, the belt ring can adapt to different patients, and the comfort level of the patients is improved; and through the arranged one-way locking mechanism, the belt ring is prevented from being automatically loosened, and the pressure air bag can stably and continuously press the annular cartilage of the patient.

Disclosed are tetrahydroisoquinoline compounds useful for treating an opioid receptor- associated condition including pain, immune disease, esophageal reflux, diarrhea, anxiety, or heroin addiction. Also provided are pharmaceutical compositions and treatment methods.

The invention discloses a medicinal moxa composition for preventing and treating chronic gastroenteritis combined with esophageal reflux, which comprises rhizoma atractylodis, wrinkled gianthyssop herb, fortune eupatorium herb and moxa, and can improve the symptoms of chronic gastroenteritis and esophageal reflux through the effects of strengthening spleen and stomach, eliminating dampness and dissolving turbidity, regulating qi and relieving pain and the like. Agastache rugosus is used for resolving dampness and regulating the middle warmer, fortune eupatorium herb is used for enlivening the spleen and promoting appetite, and the four medicines are compatible to form a balanced system for strengthening the spleen and stomach and eliminating dampness and turbidity. A plurality of volatile active ingredients of the medicinal moxa composition act on a plurality of key targets related to chronic gastroenteritis and esophageal reflux co-disease through moxibustion. Volatile components generated by combustion of the medicinal moxa composition directly act on esophageal mucosa and spleen and stomach areas, a'local-whole body 'synergistic effect mode is formed in combination with a warm effect and meridian stimulation, and a new thought and theoretical basis are provided for prevention and treatment of chronic gastroenteritis combined with esophageal reflux.

The present application belongs to the technical field of gastroscopy, and particularly relates to an auxiliary device for gastroesophageal reflux examination, which comprises an expandable sleeve assembly and a gastroscope assembly. The diameter of the expandable sleeve assembly can be changed. When the diameter of the expandable sleeve assembly is at a minimum value, the diameter of the expandable sleeve assembly is smaller than that of the gastroscope assembly. When the diameter of the expandable sleeve assembly is at a maximum value, the gastroscope assembly can be slidably inserted into the inside of the expandable sleeve assembly. The present application adopts a double-layer sleeve insertion structure. First, the expandable sleeve assembly in a contracted state with a smaller diameter is inserted into the esophagus to reduce the discomfort of the patient. Then, the expandable sleeve assembly is unfolded from the folded and contracted state to a hollow tube structure with a larger diameter. Then, the gastroscope assembly is inserted into the inside of the expandable sleeve assembly to complete the insertion of the gastroscope.

The utility model discloses a visual pH catheter for real-time reflux monitoring of gastroesophageal reflux disease, and belongs to the technical field of medical instruments. Comprising a catheter body, a camera module is installed at the head end of the catheter body, a pH electrode is arranged on the catheter wall, close to the head end, of the catheter body, and a transmission cable is arranged in the catheter body in a penetrating mode and used for supplying power to the camera module and the pH electrode and transmitting data. The pH electrode comprises a pH reference electrode and a pH working electrode, and the pH reference electrode and the pH working electrode are fixed on the catheter wall of the catheter body in parallel. According to the utility model, synchronous observation of a pH curve and a reflux video can be obtained, the relationship between reflux and esophageal movement can be judged, and visual evidence is provided for kinetic research of gastroesophageal reflux.

The utility model relates to an animal experiment device. The utility model discloses a gastroesophageal reflux chest pain modeling and treatment combined animal experiment device. The animal experiment device comprises a centralized sleeve, a fixed gastric sac assembly, an esophageal physical stimulation balloon assembly and a medicine stimulation assembly, the fixed gastric sac assembly comprises a first fixed balloon and a first fixed pipeline; the esophagus physical stimulation balloon assembly comprises a second stimulation balloon and a second stimulation pipeline; the medicine stimulation assembly comprises a medicine injection pipe, the medicine injection pipe and the concentration sleeve are arranged inside and outside, and the lower end of the medicine injection pipe is provided with a medicine injection opening which extends outwards and is in butt joint with the outer side of the concentration sleeve. And the lower end part of the concentration sleeve is sequentially provided with an injection part which is butted and communicated with the medicine injection port, a second fixing part for fixing the second stimulation balloon and a first fixing part for fixing the first fixing balloon from top to bottom. By means of the medicine stimulation assembly and the esophagus physical stimulation balloon assembly, switching use or combined use of chemical stimulation and physical stimulation is achieved for modeling.

The present application relates to the field of food technology, and specifically discloses a composition for reducing gastroesophageal reflux in individuals, a preparation method and application thereof. The composition for reducing gastroesophageal reflux in individuals comprises lactadherin, medium-long chain triglyceride, human milk oligosaccharide and immunoglobulin G. The present application constructs a multi-target synergistic intervention mechanism combining physical protection, secretion regulation and tissue repair through the compounding of four core components, which can comprehensively block the occurrence and development of gastroesophageal reflux. Lactadherin constructs a physical barrier to reduce the risk of reflux dynamics from the source; MLCT precisely regulates gastric acid secretion, reducing chemical stimulation; HMO compound IgG strengthens the mucosal immune barrier and promotes damage repair. The above composition is applied to products for reducing gastroesophageal reflux in individuals, and multi-target synergistic effect is achieved, realizing the whole-chain closed-loop intervention from prevention, relief to repair, and significantly improving the clinical improvement effect.

The invention discloses a physiotherapy vest for relieving or treating gastroesophageal reflux cough and a use method. A physical therapy vest for relieving or treating gastroesophageal reflux cough comprises a vest base body, the vest base body comprises a front fabric and a rear fabric, the left side and the right side of the front fabric are connected with the left side and the right side of the rear fabric respectively, and the physical therapy vest is characterized in that each of the front fabric and the rear fabric comprises a left fabric, a middle physical therapy area and a right fabric which are sequentially connected from left to right; each middle physical therapy area comprises a fabric surface layer, a massage layer, a heating layer, a medicine application interlayer and a medicine penetration isolation layer which are sequentially arranged from outside to inside, and an opening used for detaching the medicine application interlayer is formed in each middle physical therapy area. Through multiple traditional Chinese medicine therapies of hot ironing and application medicine penetration, comprehensive treatment can be effectively formed on gastroesophageal reflux cough, and the stomach-esophageal reflux cough treatment device is in a vest style, is convenient to wear and is convenient for daily treatment of a user.

The invention relates to the technical field of medical instruments, and discloses an airway and esophagus reflux protection monitoring system based on fluorescence imaging. The existing non-invasive monitoring method has the problems that equipment wearing is unstable, a light window is easy to pollute and the like, so that the monitoring accuracy is influenced. The system comprises an in-vitro imaging module, a fluorescent diaphragm and a necklace. The in-vitro imaging module is worn on the anterior neck of a patient to detect a fluorescence signal; the fluorescent diaphragm is swallowed by a patient, consists of a pepsin response layer and a pH sensitive indication layer, and can emit a fluorescent signal according to the pH value change of gastric juice; the air bag is arranged in the elastic band of the necklace, the connecting base can stably abut against the lower portion of the laryngeal knot after inflation, and the cleaning assembly is arranged on the connecting base and can automatically clean an in-vitro imaging module light window. The system realizes efficient and accurate monitoring of airway and esophageal reflux, provides a reliable basis for clinical diagnosis, and is suitable for monitoring airway and esophageal reflux conditions.

The utility model discloses an implantable tissue fastener for treating gastroesophageal reflux diseases. The implantable tissue fastener comprises a fixing ring, a supporting air bag and a positioning net rack, the fixing ring is arranged at the gastric cardia of a patient; the supporting air bag is fixedly arranged on the inner wall of the fixing ring, the two ends of the supporting air bag are distributed on the two sides of the fixing ring, the supporting air bag is in a linear column shape in an uninflated state, and the supporting air bag surrounds the fixing ring in an inflated state; the positioning net frames are arranged at the two ends of the fixing ring, the supporting air bag is wrapped with the positioning net frames, and the positioning net frames are used for positioning the supporting space of the supporting air bag. The guide wire is used for sending the fastening piece to the gastric cardia of a patient, then the supporting air bag is inflated to enable the supporting air bag to be attached to and block the inner side wall and the outer side wall of the gastric cardia of the patient, the gastroesophageal reflux problem can be effectively solved, and the gastroesophageal reflux device has the advantages of being simple in structure and convenient and fast to operate.

The present invention discloses an asymmetric anastomat with anti-reflux effect for esophagogastric anastomosis, the improvements lie in that the end face of a nail bin is formed by two arc-shaped plates that are bent towards the same direction and connected and closed in an end-to-end manner to form an arc-shaped cavity, nail outlet holes in the arc-shaped plates are provided around the arc-shaped cavity, and a cutter is consistent with the arc-shaped cavity in shape and is attached to the edge of the inner side wall of the arc-shaped cavity; a stapling anvil plate on the bottom face of the nail abutting base is formed by working out a cutting groove in a circular plate, the shape of the cutting groove is consistent with the shape of the arc-shaped cavity in the end face of the nail bin, and nail abutting grooves that match the nail outlet holes in position and shape are formed in the stapling anvil plate. After anastomosis with the asymmetric anastomat for esophagus and stomach in the present invention, redundant esophageal and gastric tissues on the anterior wall are deformed into the stomach to form a tongue piece by suturing to a seromuscular layer, and, in conjunction with manual folding and suturing at the posterior wall, valvula-like tongue pieces that are closed towards each other are formed in the stomach cavity, so that a valvula-like structure is formed together. The anastomotic stoma passage is in a valvula-like closed state when no food is eaten, and the anastomotic stoma is opened due to the peristalsis pressure of the esophagus and an expansion effect of a food mass during eating, so that a cardia-like effect of preventing stomach-esophageal reflux is achieved.

The present patent application relates to an oral composition comprising: palmitoylethanolamide, dry extract of Musa paradisiaca, dry extract of Zingiber officinale, a mixture containing a dry extract of Opuntia ficus-indica and a dry extract of Olea europaea, for use in the prevention and / or in the treatment.